CN104274572A - Traditional Chinese veterinary medicine composition and preparation method thereof - Google Patents
Traditional Chinese veterinary medicine composition and preparation method thereof Download PDFInfo
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/06—Fungi, e.g. yeasts
- A61K36/07—Basidiomycota, e.g. Cryptococcus
- A61K36/076—Poria
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/284—Atractylodes
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/288—Taraxacum (dandelion)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/35—Caprifoliaceae (Honeysuckle family)
- A61K36/355—Lonicera (honeysuckle)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/484—Glycyrrhiza (licorice)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/489—Sophora, e.g. necklacepod or mamani
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/51—Gentianaceae (Gentian family)
- A61K36/515—Gentiana
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/539—Scutellaria (skullcap)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/63—Oleaceae (Olive family), e.g. jasmine, lilac or ash tree
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
- A61K36/736—Prunus, e.g. plum, cherry, peach, apricot or almond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/75—Rutaceae (Rue family)
- A61K36/756—Phellodendron, e.g. corktree
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/10—Preparation or pretreatment of starting material
- A61K2236/15—Preparation or pretreatment of starting material involving mechanical treatment, e.g. chopping up, cutting or grinding
Abstract
The invention discloses a traditional Chinese veterinary medicine composition and a preparation method thereof, and the traditional Chinese veterinary medicine composition is mainly composed of the following parts by weight of component: 1-100 parts of Chinese pulsatilla root, 1-50 parts of dandelion, 1-50 parts of radix scutellariae, 1-50 parts of honeysuckle, 1-30 parts of cortex phellodendri, 1-50 parts of sophora flavescens, 1-30 parts of gentian, 1-30 parts of white atractylodes rhizome, 1-30 parts of rhizoma smilacis glabrae, 1-30 parts of radix paeoniae alba, 1-50 parts of cortex fraxini, 1-30 parts of dark plum and 1-30 parts of licorice. The traditional Chinese veterinary medicine composition can be prepared into any kind of common oral preparations such as a pill, a capsule, a tablet, powder, granules, an oral liquid and the like. The traditional Chinese veterinary medicine pullorum disease prevention composition can be significant in curative effect on treatment of pullorum disease, is very obvious in the prevention effect, has good prospects in application and promotion and promotes the healthy development of pollution-free cultivation and non-residue green meat food processing industry.
Description
Technical field
The present invention relates to a kind of herbal medicine, particularly a kind of take Chinese herbal medicine as Chinese veterinary medicinal composition preventing and treating Pullorum Disease of crude drug and preparation method thereof.
Background technology
White diarrhea disease is that Salmonella pullon infection is fallen ill, and is a kind of bacterial infectious disease that common hazardness is very large.Primary disease shows as acute chickling, newborn young in acute sepsis, 20-45 age in days young bird is in subacute, and Adult Chicken accidentally also has generation.It is very high that chickling suffers from this sick mortality rate, and Adult Chicken laying rate and incubation rate reduce.
Primary disease mainly encroaches on chickling.Except chicken, naturally infect and be also once found in turkey, duck, guinea fowl, wild fowl Fang Jianyou occurs.
The infection of primary disease by various approach, the infection of the egg that mainly carries disease germs.A large amount of pathogen is had in infected Chickens, most with feces discharge, pollute feedstuff, drinking-water, infect healthy chick again.The chicken that carries disease germs is become after ill chickling survives, because its ovary is infected, so that the ovum major part of producing is all containing Hakuri bacterium, also containing Hakuri bacterium in the feces of discharging, just healthy one-tenth chicken can be transmitted to, the infection of this disease is wide, and mortality rate is high, and the popular of this disease brings heavy losses often to poultry owner.
This disease all has popular in various places, be also main quarantine object in international chicken, the import and export of egg series products.
Primary disease is that the medicine at present for this disease of prevention and therapy is mostly antibiotic formulations to one of very large infectious disease of poultry husbandry harm, as the tetracycline same clan, and penicillin and streptomycin class.Some poultry family, in order to reduce the generation of Pullorum Disease, is added the medicine such as oxytetracycline, chlortetracycline for a long time and is prevented.Though these medicines have certain prevention effect, but there is weak curative effect, chickling mortality rate is high, and life-time service antibiotic can produce drug resistance to chicken, chicken drug disposition is residual to exceed standard, directly affect the outlet of chicken product, cause its residual meat, egg product exceeded standard can cause direct harm to human health.
Utilizing pure natural Chinese herbal medicine substitute antibiotics goods, is the trend of following aquaculture medication.
In order to overcome above-mentioned defect, the present invention is based on Chinese veterinarian and treat the differential diagnosis of diseases of Pullorum Disease and the dialectical principle combined, treating both the principal and secondary aspects of a disease, deficiency and excess is also controlled, inside and outside logical tune, emergency is taken in concurrently, filters out the natural plant of invigorating spleen to remove dampness, heat-clearing and toxic substances removing, dampness-eliminating and dysentery-stopping, according to the theoretical prescription of Chinese veterinarian, be prepared from according to certain weight ratio.The Chinese veterinary medicinal composition of the prevention and therapy Pullorum Disease providing a kind of evident in efficacy, with low cost, noresidue, toxic and side effects minimum.
Above-mentioned Chinese veterinary medicinal composition of the present invention adds the various adjuvants that the different dosage form of preparation can accept on galenic pharmacy, such as disintegrating agent, lubricant, vigorous mixture etc. are prepared into the conventional oral formulations of any one with the Chinese veterinary drug preparation method of routine, such as, may be pill, capsule, tablet, powder, granule or oral liquid etc.
Summary of the invention
Technical problem to be solved by this invention provides the Chinese veterinary medicinal composition preventing and treating Pullorum Disease of a kind of evident in efficacy, with low cost, noresidue, almost non-toxic side effect for overcoming above-described shortcoming.
Technical problem to be solved by this invention is realized by following technological approaches.
A kind of Chinese veterinary medicinal composition preventing and treating Pullorum Disease of the present invention, is mainly the component composition of following weight portion:
Radix Pulsatillae 1-100 part, Herba Taraxaci 1-50 part, Radix Scutellariae 1-50 part, full Flos Lonicerae 1-50 part, Cortex Phellodendri 1-30 part, Radix Sophorae Flavescentis 1-50 part, Radix Gentianae 1-30 part, Rhizoma Atractylodis Macrocephalae 1-30 part, Poria 1-30 part, the Radix Paeoniae Alba-30 parts, Cortex Fraxini 1-50 part, Fructus Mume 1-30 part, Radix Glycyrrhizae 1-30 part
Be preferably: the Radix Pulsatillae 30 parts, Herba Taraxaci 20 parts, Radix Scutellariae 20 parts, Flos Lonicerae 15 parts, Cortex Phellodendri 10 parts, Radix Sophorae Flavescentis 20 parts, Radix Gentianae 10 parts, the Rhizoma Atractylodis Macrocephalae 15 parts, 20 parts, Poria, the Radix Paeoniae Alba 15 parts, Cortex Fraxini 20 parts, Fructus Mume 10 parts, 10 parts, Radix Glycyrrhizae.
Above-mentioned Chinese veterinary medicinal composition of the present invention adds the various adjuvants that can accept on pharmaceutics required when preparing different dosage form, such as disintegrating agent, lubricant, binding agent etc. are prepared into the conventional oral formulations of any one with the Chinese veterinary drug preparation method of routine, such as, can be pill, capsule, tablet, powder, granule or oral liquid etc.
Chinese veterinary medicinal composition of the present invention uses the principle of Chinese veterinarian's principle-method-recipe-medicines, on the basis of dialectical legislation, selecting the medicine according with the state of an illness, its objective is the needs in order to be suitable for the complicated state of an illness, play the synergism of medicine.
The present invention, with the Radix Pulsatillae, Herba Taraxaci, Radix Scutellariae, Flos Lonicerae, Cortex Phellodendri heat-clearing and toxic substances removing, dampness-eliminating and dysentery-stopping, is principal agent altogether; Radix Sophorae Flavescentis, Radix Gentianae dampness are detoxified, and the Rhizoma Atractylodis Macrocephalae, Poria invigorating spleen for diuresis antidiarrheal are accessory drugs; Cortex Fraxini, Fructus Mume dampness astringent therapy antidiarrheal are adjuvant drug; Radix Glycyrrhizae coordinating the actions of various ingredients in a prescription is for making.All medicines match, treating both the principal and secondary aspects of a disease.
The present invention's herbal raw material used all can be buied from Chinese medicine shop, and its specification meets " Chinese veterinary pharmacopoeia " and relevant National Veterinary medicine standard.
Usage and dosage: dosage of the present invention depends on concrete dosage form, the factors such as the size of chicken (as young bird, growing chickens, large chicken etc.), body weight, prevention or treatment are as guidance: for oral administration: 1) capsule: sick large chicken, every day 3 times, each throwing takes 3, every content of dispersion 0. 3 grams.2) tablet: sick growing chickens, every day 3 times, each throwing takes 2, sick large chicken 3, every sheet content of dispersion 0. 3 grams.
3) pill: sick poult, every day 3 times, each throwing takes 3, and sick growing chickens is thrown at every turn and taken 5, and sick large chicken is thrown at every turn and takes 10, every 10 piller content of dispersion 1 gram.4) powder, granule: for prevention or treatment, poult adds 1. 5 (prevention)-2% (treatment) in feedstuff; Growing chickens adds 0.75 (prevention)-1.0 (treatment) in feedstuff; Large chicken adds 0.5 (prevention)-1.0 (treatment) in feedstuff; 5) oral liquid: poult adds 0.75 (prevention)-1.0% (treatment) in drinking water; Growing chickens adds 0.5 (prevention)-1.0 (treatment) in drinking water; Large chicken adds 0.25 (prevention)-0.5 (treatment) in drinking water.
The prevention and therapy that the present invention is directed to Pullorum Disease is very effective, various crude drug is coordinated can play at utmost to play drug effect mutually together, effectively can improve the resistance against diseases of disease chicken body, the Radix Pulsatillae in we, Radix Sophorae Flavescentis, the heat-clearing and toxic substances removing such as Cortex Fraxini, heat clearing and damp drying, eliminating pathogenic heat from blood to cure dysentery, Herba Taraxaci, Radix Scutellariae, Flos Lonicerae, the heat-clearing and toxic substances removing such as Cortex Phellodendri, dysentery relieving, Fructus Mume relieving diarrhea with astringents, Radix Gentianae dampness is detoxified, the Rhizoma Atractylodis Macrocephalae in side, Poria invigorating spleen for diuresis antidiarrheal, strengthening spleen and nourishing blood, Rhizoma Atractylodis Macrocephalae air making-up and spleen enlivening, the Radix Paeoniae Alba is nourished blood and blood, from modern Chinese medicine pharmacological research, the Rhizoma Atractylodis Macrocephalae has the effect of enhancing human body immunity function, the Radix Paeoniae Alba has spasmolysis to intestinal smooth, multiple enteric pathogenic bacteria can be suppressed simultaneously, the Radix Glycyrrhizae mediation property of medicine, for the treatment of white diarrhea disease and preventive effect obvious, and also have and have no side effect, the advantages such as expense is lower.
Detailed description of the invention
Further describe the present invention by the following examples, be construed as, these embodiments only for the object of illustration, are never limited to the present invention.
embodiment 1
The preparation of capsule
Each raw material is taken: the Radix Pulsatillae 30 parts, Herba Taraxaci 20 parts, Radix Scutellariae 20 parts, Flos Lonicerae 15 parts, Cortex Phellodendri 10 parts, Radix Sophorae Flavescentis 20 parts, Radix Gentianae 10 parts, the Rhizoma Atractylodis Macrocephalae 15 parts, 20 parts, Poria, the Radix Paeoniae Alba 15 parts, Cortex Fraxini 20 parts, Fructus Mume 10 parts, 10 parts, Radix Glycyrrhizae by following weight portion.
By the mixing of each for above-mentioned weight portion raw material, be ground into fine powder and cross 600-800 mesh sieve and incapsulate.
embodiment 2
Each raw material is taken: the Radix Pulsatillae 30 parts, Herba Taraxaci 20 parts, Radix Scutellariae 20 parts, Flos Lonicerae 15 parts, Cortex Phellodendri 10 parts, Radix Sophorae Flavescentis 20 parts, Radix Gentianae 10 parts, the Rhizoma Atractylodis Macrocephalae 15 parts, 20 parts, Poria, the Radix Paeoniae Alba 15 parts, Cortex Fraxini 20 parts, Fructus Mume 10 parts, 10 parts, Radix Glycyrrhizae by following weight portion.By the mixing of each for above-mentioned weight portion raw material, be ground into after fine powder crosses 1200-1500 mesh sieve, make tablet.
embodiment 3
Each raw material is taken: the Radix Pulsatillae 30 parts, Herba Taraxaci 20 parts, Radix Scutellariae 20 parts, Flos Lonicerae 15 parts, Cortex Phellodendri 10 parts, Radix Sophorae Flavescentis 20 parts, Radix Gentianae 10 parts, the Rhizoma Atractylodis Macrocephalae 15 parts, 20 parts, Poria, the Radix Paeoniae Alba 15 parts, Cortex Fraxini 20 parts, Fructus Mume 10 parts, 10 parts, Radix Glycyrrhizae by following weight portion.By each for above-mentioned weight portion raw material mixing, after crossing 1200-1500 mesh sieve after being ground into fine powder, make pill and both obtained.
embodiment 4
Each raw material is taken: the Radix Pulsatillae 30 parts, Herba Taraxaci 20 parts, Radix Scutellariae 20 parts, Flos Lonicerae 15 parts, Cortex Phellodendri 10 parts, Radix Sophorae Flavescentis 20 parts, Radix Gentianae 10 parts, the Rhizoma Atractylodis Macrocephalae 15 parts, 20 parts, Poria, the Radix Paeoniae Alba 15 parts, Cortex Fraxini 20 parts, Fructus Mume 10 parts, 10 parts, Radix Glycyrrhizae by following weight portion.By the mixing of each for above-mentioned weight portion raw material, be ground into after fine powder crosses 1200-1500 mesh sieve, add ethanol and make adhesive, add starch and make filler, in Drygranulatemachine, be directly pressed into granule.
Claims (5)
1. a Chinese veterinary medicinal composition, it is characterized in that, the component by following weight portion: Radix Pulsatillae 1-100 part, Herba Taraxaci 1-50 part, Radix Scutellariae 1-50 part, Flos Lonicerae 1-50 part, Cortex Phellodendri 1-30 part, Radix Sophorae Flavescentis 1-50 part, Radix Gentianae 1-30 part, Rhizoma Atractylodis Macrocephalae 1-30 part, Poria 1-30 part, Radix Paeoniae Alba 1-30 part, Cortex Fraxini 1-50 part, Fructus Mume 1-30 part, Radix Glycyrrhizae 1-30 part form.
2. a kind of Chinese veterinary medicinal composition according to claim 1, it is characterized in that, said Chinese veterinary medicinal composition is by the crude drug of following weight portion: the Radix Pulsatillae 30 parts, Herba Taraxaci 20 parts, Radix Scutellariae 20 parts, Flos Lonicerae 15 parts, Cortex Phellodendri 10 parts, Radix Sophorae Flavescentis 20 parts, Radix Gentianae 10 parts, the Rhizoma Atractylodis Macrocephalae 15 parts, 20 parts, Poria, the Radix Paeoniae Alba 15 parts, Cortex Fraxini 20 parts, Fructus Mume 10 parts, 10 parts, Radix Glycyrrhizae are made.
3. according to Chinese veterinary medicinal composition according to claim 2, it is characterized in that: Chinese veterinary drug preparation method is conveniently prepared into the conventional oral formulations of any one.
4. according to Chinese veterinary medicinal composition according to claim 3, it is characterized in that: described oral formulations is pill, capsule, tablet, powder, granule or oral liquid.
5. the application of the Chinese veterinary medicinal composition of claim 1-4 described in any one in preparation control white diarrhea disease.
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