CN116370398B - Pickering emulsion stabilizing composition, emulsion type skin care product and preparation method thereof - Google Patents
Pickering emulsion stabilizing composition, emulsion type skin care product and preparation method thereof Download PDFInfo
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- CN116370398B CN116370398B CN202310447621.3A CN202310447621A CN116370398B CN 116370398 B CN116370398 B CN 116370398B CN 202310447621 A CN202310447621 A CN 202310447621A CN 116370398 B CN116370398 B CN 116370398B
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- pickering emulsion
- pickering
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- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
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Abstract
The invention discloses a pickering emulsion stabilizing composition, an emulsion type skin care product and a preparation method thereof. The invention is characterized in that microcrystalline cellulose, a sphingomonas fermentation product extract and cellulose gum are compounded into a Pickering composition A; and then the Pickering emulsion stabilizing composition is compounded by the Pickering composition A and SymReboot TM L19. The Pickering emulsion stabilizing composition can be further added with preservative, polyalcohol, chelating agent, grease, functional components and purified water to prepare emulsion type skin care product. The skin care product prepared by adopting the composition can realize more stable formula, lower irritation and good skin repairing effect under the condition of no emulsifying agent, can realize synergistic repairing effect and reduce the use cost. Meanwhile, the preparation method of the skin care product is simpler, has wider requirements on the process, can be prepared at normal temperature, and greatly reduces the energy consumption of production.
Description
Technical Field
The invention relates to the technical field of cosmetics, in particular to a pickering emulsion stabilizing composition, an emulsion type skin care product and a preparation method thereof.
Background
Sensitive skin is an unhealthy skin type (hereinafter referred to as sensitive muscle), and the barrier protection of the epidermis of the skin is generally very weak, and proper adaptation to external environmental stimuli cannot be made, thereby causing various uncomfortable reactions to the skin. Sensitive muscles are commonly represented by weaker horny layers and unhealthy sebum films, some sensitive skin can directly see obvious vascular filaments, when the horny function of the skin is not healthy, the skin cannot maintain complete moisture, and the skin starts to dry and crack; in addition, the immunity of the skin is also deteriorated, and the skin cannot be perfectly resisted, so long as the skin is contacted with a stimulating substance, for example: dust, solar ultraviolet rays, irritant gases, unclean water, pollen or cosmetics containing irritant ingredients and the like can cause skin allergy, and a series of skin problems occur. Therefore, when selecting skin care products, the sensitive muscle groups need to have good barrier efficacy, and the irritation of the products is low enough to avoid the phenomenon of secondary allergy of the faces.
Pickering emulsions are a new type of emulsion system in which solid particles replace conventional surfactant-stabilized emulsions. The use of solid particles as emulsifiers in cosmetics has a more positive performance than conventional surfactant-stabilized emulsions. The solid particles are used as emulsifying agent in cosmetics, so that the long-term thermodynamic stability of an emulsifying system can be maintained, and the irritation of the product to human skin caused by the self-properties of the surfactant is reduced.
At present, a great deal of research is carried out on formulation rules and physical characterization of Pickering emulsion, but the research is limited to inorganic particles such as silicon dioxide and other silicon, the particle size of the inorganic ions is unfavorable for digestion and metabolism, and meanwhile, synthetic sources limit the attraction of the inorganic ions in the aspects of sustainable development and label cleaning potential, so that the bio-based particles have important significance in future cosmetics.
Some bio-based pickering particles have been developed over the past few years, such as modified starch particles, cellulose fibers, cellulose nanocrystals, fat particles, chitin nanocrystals, flavonoids and other protein-based particles. However, most of the above particles require chemical modification or additional treatments such as heating, hydrophobic grafting or anti-solvent precipitation, which do not meet the trend of "green, sustainable".
Therefore, how to develop a more gentle, better-efficacy, greener pickering skin care product for sensitive muscle groups is a problem to be solved at present.
Disclosure of Invention
Aiming at the defects in the prior art, the invention provides a pickering emulsion stabilizing composition which can be used for preparing pickering emulsion type skin care products. The skin care product prepared by adopting the composition can realize more stable formula, lower irritation and good skin repairing effect under the condition of no emulsifying agent, can realize synergistic repairing effect and reduce the use cost. Meanwhile, the preparation method of the skin care product is simpler (the skin care product is obtained by mixing and homogenizing), the requirements on the process are wider, the skin care product can be prepared at normal temperature, the energy consumption of production is greatly reduced, and the concept of sustainable development is more met.
In order to achieve the technical purpose, the technical scheme provided by the invention is as follows: the pickering emulsion stabilizing composition comprises the following components in percentage by weight based on the total weight: 30-95% of Pickering composition A and 5-70% of SymReboot TM L19; the Pickering composition A comprises the following components in percentage by weight: 65-70% of microcrystalline cellulose, 20-25% of sphingomonas fermentation product extract and 8-10% of cellulose gum.
Preferably, the weight percentages of the components are: 60-80% of Pickering composition A and 20-40% of SymReboot TM L; the optimal proportion is as follows: pickering composition A70%, symReboot TM L19% 30%.
Preferably, the grain size of SymReboot TM L19 is 300-500nm, the microstructure is in a regular sphere shape, and the SymReboot TM L19 raw material is mechanically ball-milled to obtain SymReboot TM L19 meeting the grain size requirement.
Preferably, the pickering composition a comprises the following components in percentage by weight: 68% of microcrystalline cellulose, 23% of sphingomonas fermentation product extract and 9% of cellulose gum.
The action of each raw material is introduced:
Microcrystalline cellulose: microcrystalline cellulose (MCC, microcrystalline cellulose) is a white, odorless, tasteless crystalline powder consisting of very fine short rod-like or powdery porous particles of natural cellulose free flowing, hydrolyzed by dilute acid to a limited degree of polymerization (LODP), and has a main component of linear polysaccharide bound by beta-1, 4-glucosidic bonds. The particle size is generally 20-80 μm, the ultimate polymerization degree (LODP) is 15-375, and the fluidity is extremely strong without fibrosis. Is insoluble in water, dilute acid, organic solvent and grease, is partially dissolved in dilute alkali solution, is moist and swelled, and has higher reactivity in the processes of carboxymethylation, acetylation and esterification. Microcrystalline cellulose is widely used in the industries of medicine, food, cosmetics and the like due to its special properties such as low polymerization degree and large specific surface area.
Sphingomonas fermentation product extract: sphingomonas (Sphingomonas) fermentation product extract is a natural fermentation polysaccharide produced by sustainable fermentation and has excellent stability under high temperature, extreme pH and high salt conditions.
Cellulose gum: cellulose gum is an anionic water-soluble cellulose derivative. The appearance is white or milky fiber powder or granule, the density is 0.5-0.7 g/cm 3, the product is almost odorless and tasteless, and has hygroscopicity. Is easy to disperse in water to form transparent colloidal solution, and is insoluble in organic solvent such as ethanol. The important characteristics are that a high-viscosity colloid solution is formed, and the colloid solution has the characteristics of adhesion, thickening, flowing, emulsifying and dispersing, shaping, water retention, protective colloid, film forming, acid resistance, salt resistance, suspension and the like, is physiological harmless, and is widely applied to the production in the fields of food, medicine, daily chemicals, petroleum, papermaking, textile, building and the like.
SymReboot TM L19: symReboot L19 is an inactivated probiotic bacterial body skin care component pushed out by Delrin, symReboot TM L19 is obtained by processing lactobacillus, can simulate the action of living bacteria in skin care application, regulate the expression of antibacterial peptide, regulate the balance of surface layer microbial flora, and achieve the effects of relieving skin and enhancing skin barrier.
The invention also aims at providing a Pickering emulsion type skin care product containing the Pickering emulsion stabilizing composition, which comprises the following components in parts by weight: 0.05 to 10 parts of Pickering emulsion stabilizing composition, 0 to 2 parts of preservative, 0 to 15 parts of polyalcohol, 0 to 2 parts of chelating agent, 0 to 20 parts of grease, 0 to 99 parts of functional components and 100 parts of purified water.
The preservative is as follows: one or more of the group consisting of umarone, hexylene glycol, phenoxyethanol, but not limited to preservative ingredients commonly found on the market.
The polyol is as follows: one or more of dipropylene glycol, glycerin, butylene glycol, pentylene glycol, but not limited to polyol ingredients commonly found on the market.
The chelating agent is as follows: one or more of EDTA-2Na, EDTA-4Na, sodium hexametaphosphate, but not limited to the chelating agent ingredients commonly found on the market.
The grease is as follows: one or more of dioctyl carbonate, caprylic/capric triglyceride, squalane, white pool flower seed oil, sunflower seed oil, silicone oil, vitamin E acetate, hydrogenated polyisobutene, isononyl isononanoate, C12-15 alcohol benzoate, malla oil, emu oil, sweet almond oil, C9-12 alkane, coco alcohol-caprylic/capric ester, polydimethylsiloxane, plant squalane, isooctyl palmitate, isopropyl myristate, but not limited to the common oil and fat ingredients on the market.
The functional components are as follows: water-soluble functional components and oil-soluble functional components. Wherein, the water-soluble functional components comprise: one or more of hydrogenated lecithin, oat glucan, sodium hyaluronate, oat kernel extract, citrus fruit extract, but not limited to water-soluble functional ingredients commonly found on the market; an oil-soluble functional ingredient comprising: one or more of coenzyme Q10, astaxanthin, white pond flower seed oil and squalane, but not limited to common oil-soluble functional components on the market.
The preferable proportion is as follows: 0.5 to 1.0 part of Pickering emulsion stabilizing composition, 0.05 to 1 part of preservative, 5 to 8 parts of polyalcohol and 0.01 to 0.1 part of chelating agent; 10-20 parts of grease, 3-10 parts of functional components and 100 parts of water; the grease at least comprises 2 parts of white pool flower seed oil.
The preparation method of the pickering emulsion skin care product comprises the following steps:
s1: weighing the components according to the Pickering emulsion type skin care product formula;
S2: under the normal temperature condition, adding purified water into an emulsifying tank, and then sequentially adding a pickering emulsion stabilizing composition, a preservative, a polyalcohol, a chelating agent and water-soluble functional components, wherein the stirring speed is kept at 10-500 r/min, and stirring and dissolving at normal temperature for 10-40 min to obtain a component A;
s3: under the normal temperature condition, putting the grease and the oil-soluble functional components into an oil phase pre-preparing tank to obtain a component B;
s4: pumping the component B into an emulsifying tank of the component A at one time under the normal temperature condition, homogenizing at 2000-5000 rpm, and homogenizing and emulsifying for 5-18 min;
s5: and after homogenizing and emulsifying, filtering and discharging, and filling after the inspection is qualified to obtain the Pickering emulsion type skin care product.
Preferably, the stirring rotation speed in the step S2 is kept at 60r/min, and the stirring dissolution time is 15min.
Preferably, the homogenization rate in the step S4 is 2500rpm, and the homogenization time is 6min.
The invention adopts the Pickering composition A and SymReboot TM L19 to compound and prepare the Pickering emulsion stabilizing composition, wherein SymReboot TM L19 plays roles in relieving skin and enhancing skin barrier, the Pickering composition A is prepared by compounding microcrystalline cellulose, a sphingomonas fermentation product extract and cellulose gum, wherein the microcrystalline cellulose serves as colloidal particles of a system to play an emulsification stabilizing role, and meanwhile, the sphingomonas fermentation product extract, the cellulose gum and the microcrystalline cellulose cooperate to form the Pickering composition A with better stability. Experiments prove that the stability of the Pickering composition A and SymReboot TM L19 after being compounded is better than that of the Pickering composition A and SymReboot TM L19 after being singly used, and in addition, the composition has a certain synergistic effect after being compounded with the Begonia seed oil for use, thereby promoting skin repair. Therefore, the invention can realize more stable formulation and lower irritation under the condition of no emulsifying agent, has good skin repairing effect and reduces the use cost.
The invention has the technical effects that: the pickering emulsion stable composition and the pickering emulsion skin care product prepared by the invention can realize more stable formula and lower irritation under the condition of no emulsifying agent, have good skin repairing effect, can realize synergistic repairing effect and reduce the use cost, have simpler preparation method, are obtained by mixing and homogenizing, have wider requirements on the process, can be prepared at normal temperature, greatly reduce the energy consumption of production and accord with the concept of sustainable development.
Drawings
FIG. 1 is a photomicrograph (100 times) of the Pickering emulsion type skin care product prepared in example 1;
FIG. 2 is a sample picture of the Pickering emulsion type skin care product prepared in example 1;
FIG. 3 is a graph showing the rate of change of TEWL value for skin moisture loss after 28 days;
fig. 4 is a graph showing the rate of change of the values of the analysis a of the facial red area after 28 days.
Detailed Description
The effects thereof are described below with reference to the embodiments and drawings.
The Sphingomonas fermentation product extract used in this example was derived from CP KELCO (Shandong) Biological Co.Ltd; symReboot TM L19 was derived from De Xin essence perfume (Nantong) Inc.; oat kernel extract is from the biosciences of mel-a-bio-technology, inc; the citrus fruit extract is derived from Shanghai Jia Kai Biotech Co.
Example 1:
The pickering emulsion stabilizing composition comprises the following components in percentage by weight based on the total weight: pickering composition A70%, symReboot TM L19% 30%, more specifically: 47.6% of microcrystalline cellulose, 16.1% of sphingomonas fermentation product extract, 6.3% of cellulose gum and SymReboot TM L19% of water.
The pickering emulsion type skin care product comprises the following components in parts by weight:
0.7 parts of Pickering emulsion stabilizing composition;
Preservative: 0.5 part of 1, 2-hexanediol;
Polyol: 2 parts of pentanediol and 4 parts of dipropylene glycol;
chelating agent: EDTA-2Na 0.05 parts;
grease: 10 parts of caprylic/capric triglyceride, 2 parts of squalane and 3 parts of white pool flower seed oil;
The functional components are as follows: moisture-preserving functional components: oat beta glucan 0.1 part, sodium hyaluronate 0.1 part;
The soothing efficacy component: 2 parts of oat kernel extract and 2 parts of citrus fruit extract;
73.55 parts of purified water.
The preparation method of the pickering emulsion skin care product comprises the following steps:
S1: accurately weighing the components according to the formula of the Pickering emulsion type skin care product;
s2: under the normal temperature condition, adding purified water into an emulsifying tank, and then sequentially adding a pickering emulsion stabilizing composition, a preservative, a polyalcohol, a chelating agent and water-soluble functional components, wherein the stirring speed is kept at 60r/min, and stirring and dissolving are carried out for 15min at normal temperature to obtain a component A;
S3: under normal temperature, putting the grease and the oil-soluble active ingredients into an oil phase pre-preparing tank for a time to obtain a component B;
S4: pumping the component B into an emulsifying tank of the component A at one time under the normal temperature condition, homogenizing at 2500rpm, and homogenizing and emulsifying for 6min;
S5: filtering and discharging after homogenizing and emulsifying, and filling after inspection is qualified to obtain a Pickering emulsion type skin care product, wherein a microscopic photograph (100 times) of the Pickering emulsion type skin care product is shown in figure 1; the sample photograph is shown in fig. 2, and can be seen from fig. 1: the prepared Pickering emulsion skin care product has even solid particle distribution; as shown in FIG. 2, the product is milky white, uniform and stable.
Example 2 (composition ratio different):
the pickering emulsion stabilizing composition comprises the following components in percentage by weight based on the total weight: pickering composition A80%, symReboot TM L19% 20%, more specifically: 54.4% of microcrystalline cellulose, 18.4% of sphingomonas fermentation product extract, 7.2% of cellulose gum and SymReboot TM L19% of 20%.
A Pickering emulsion type skin care product comprises the following components:
0.7 parts of Pickering emulsion stabilizing composition;
Preservative: 0.5 part of 1, 2-hexanediol;
Polyol: 2 parts of pentanediol and 4 parts of dipropylene glycol;
chelating agent: EDTA-2Na 0.05 parts;
grease: 10 parts of caprylic/capric triglyceride, 2 parts of squalane and 3 parts of white pool flower seed oil;
the functional components are as follows: moisture-preserving functional components: 0.1 part of hydrogenated lecithin and 0.1 part of sodium hyaluronate;
The soothing efficacy component: 2 parts of oat kernel extract and 2 parts of citrus fruit extract;
73.55 parts of purified water.
The preparation method of the pickering emulsion skin care product comprises the following steps:
S1: accurately weighing the components according to the formula of the Pickering emulsion type skin care product;
s2: under the normal temperature condition, adding purified water into an emulsifying tank, and then sequentially adding a pickering emulsion stabilizing composition, a preservative, a polyalcohol, a chelating agent and water-soluble functional components, wherein the stirring speed is kept at 60r/min, and stirring and dissolving are carried out for 15min at normal temperature to obtain a component A;
S3: under normal temperature, putting the grease and the oil-soluble active ingredients into an oil phase pre-preparing tank for a time to obtain a component B;
S4: pumping the component B into an emulsifying tank of the component A at one time under the normal temperature condition, homogenizing at 2500rpm, and homogenizing and emulsifying for 6min;
s5: and after homogenizing and emulsifying, filtering and discharging, and filling after the inspection is qualified to obtain the Pickering emulsion type skin care product.
Example 3 (process variant):
The pickering emulsion stabilizing composition comprises the following components in percentage by weight based on the total weight: pickering composition A70%, symReboot TM L19% 30%, more specifically: 47.6% of microcrystalline cellulose, 16.1% of sphingomonas fermentation product extract, 6.3% of cellulose gum and SymReboot TM L19% of water.
A Pickering emulsion type skin care product comprises the following components:
0.7 parts of Pickering emulsion stabilizing composition;
Preservative: 0.5 part of 1, 2-hexanediol;
Polyol: 2 parts of pentanediol and 4 parts of dipropylene glycol;
chelating agent: EDTA-2Na 0.05 parts;
grease: 10 parts of caprylic/capric triglyceride, 2 parts of squalane and 3 parts of white pool flower seed oil;
The functional components are as follows: moisture-preserving functional components: oat beta glucan 0.1 part, sodium hyaluronate 0.1 part;
The soothing efficacy component: 2 parts of oat kernel extract and 2 parts of citrus fruit extract;
73.55 parts of purified water.
The preparation method of the pickering emulsion skin care product comprises the following steps:
S1: accurately weighing the components according to the formula of the Pickering emulsion type skin care product;
S2: under the normal temperature condition, adding purified water into an emulsifying tank, and then sequentially adding a pickering emulsion stabilizing composition, a preservative, a polyalcohol, a chelating agent and water-soluble functional components, wherein the stirring speed is kept at 200r/min, and stirring and dissolving are carried out for 10min at normal temperature to obtain a component A;
S3: under normal temperature, putting the grease and the oil-soluble active ingredients into an oil phase pre-preparing tank for a time to obtain a component B;
S4: pumping the component B into an emulsifying tank of the component A at one time under the normal temperature condition, homogenizing at 5000rpm, and homogenizing and emulsifying for 12min;
s5: and after homogenizing and emulsifying, filtering and discharging, and filling after the inspection is qualified to obtain the Pickering emulsion type skin care product.
Comparative example 1 (pickering composition a):
A Pickering emulsion type skin care product comprises the following components:
0.7 parts of Pickering composition A;
Preservative: 0.5 part of 1, 2-hexanediol;
Polyol: 2 parts of pentanediol and 4 parts of dipropylene glycol;
chelating agent: EDTA-2Na 0.05 parts;
grease: 10 parts of caprylic/capric triglyceride, 2 parts of squalane and 3 parts of white pool flower seed oil;
The functional components are as follows: moisture-preserving functional components: oat beta glucan 0.1 part, sodium hyaluronate 0.1 part;
The soothing efficacy component: 2 parts of oat kernel extract and 2 parts of citrus fruit extract;
73.55 parts of purified water.
The preparation method of the pickering emulsion skin care product comprises the following steps:
S1: accurately weighing the components according to the formula of the Pickering emulsion type skin care product;
S2: under the normal temperature condition, adding purified water into an emulsifying tank, and then sequentially adding the Pickering composition A, the preservative, the polyalcohol, the chelating agent and the water-soluble functional components, wherein the stirring speed is kept at 60r/min, and stirring and dissolving are carried out for 15min at normal temperature to obtain a component A;
S3: under normal temperature, putting the grease and the oil-soluble active ingredients into an oil phase pre-preparing tank for a time to obtain a component B;
S4: pumping the component B into an emulsifying tank of the component A at one time under the normal temperature condition, homogenizing at 2500rpm, and homogenizing and emulsifying for 6min;
s5: and after homogenizing and emulsifying, filtering and discharging, and filling after the inspection is qualified to obtain the Pickering emulsion type skin care product.
Comparative example 2 (SymReboot TM L19):
A Pickering emulsion type skin care product comprises the following components:
SymReboot TM L19.7 parts;
Preservative: 0.5 part of 1, 2-hexanediol;
Polyol: 2 parts of pentanediol and 4 parts of dipropylene glycol;
chelating agent: EDTA-2Na 0.05 parts;
grease: 10 parts of caprylic/capric triglyceride, 2 parts of squalane and 3 parts of white pool flower seed oil;
The functional components are as follows: moisture-preserving functional components: oat beta glucan 0.1 part, sodium hyaluronate 0.1 part;
The soothing efficacy component: 2 parts of oat kernel extract and 2 parts of citrus fruit extract;
73.55 parts of purified water.
The preparation method of the pickering emulsion skin care product comprises the following steps:
S1: accurately weighing the components according to the formula of the Pickering emulsion type skin care product;
s2: under the normal temperature condition, adding purified water into an emulsifying tank, and then sequentially adding SymReboot TM L19, preservative, polyalcohol, chelating agent and water-soluble functional components, stirring at the speed of 60r/min, and stirring at the normal temperature for dissolving for 15min to obtain a component A;
S3: under normal temperature, putting the grease and the oil-soluble active ingredients into an oil phase pre-preparing tank for a time to obtain a component B;
S4: pumping the component B into an emulsifying tank of the component A at one time under the normal temperature condition, homogenizing at 2500rpm, and homogenizing and emulsifying for 6min;
s5: and after homogenizing and emulsifying, filtering and discharging, and filling after the inspection is qualified to obtain the Pickering emulsion type skin care product.
Comparative example 3 (oil difference-no white pool flower seed oil):
The pickering emulsion stabilizing composition comprises the following components in percentage by weight based on the total weight: pickering composition A70%, symReboot TM L19% 30%, more specifically: 47.6% of microcrystalline cellulose, 16.1% of sphingomonas fermentation product extract, 6.3% of cellulose gum and SymReboot TM L19% of water.
The pickering emulsion skin care product comprises the following components:
0.7 parts of Pickering emulsion stabilizing composition;
Preservative: 0.5 part of 1, 2-hexanediol;
Polyol: 2 parts of pentanediol and 4 parts of dipropylene glycol;
chelating agent: EDTA-2Na 0.05 parts;
Grease: 13 parts of caprylic/capric triglyceride and 2 parts of squalane;
The functional components are as follows: moisture-preserving functional components: oat beta glucan 0.1 part, sodium hyaluronate 0.1 part;
The soothing efficacy component: 2 parts of oat kernel extract and 2 parts of citrus fruit extract;
73.55 parts of purified water.
The preparation method of the pickering emulsion skin care product comprises the following steps:
S1: accurately weighing the components according to the formula of the Pickering emulsion type skin care product;
s2: under the normal temperature condition, adding purified water into an emulsifying tank, and then sequentially adding a pickering emulsion stabilizing composition, a preservative, a polyalcohol, a chelating agent and water-soluble functional components, wherein the stirring speed is kept at 60r/min, and stirring and dissolving are carried out for 15min at normal temperature to obtain a component A;
S3: under normal temperature, putting the grease and the oil-soluble active ingredients into an oil phase pre-preparing tank for a time to obtain a component B;
S4: pumping the component B into an emulsifying tank of the component A at one time under the normal temperature condition, homogenizing at 2500rpm, and homogenizing and emulsifying for 6min;
s5: and after homogenizing and emulsifying, filtering and discharging, and filling after the inspection is qualified to obtain the Pickering emulsion type skin care product.
Comparative example 4 (conventional emulsifier system-containing thickener equivalent fat content):
A skin care product of conventional emulsifying system and its preparation method, the preparation composition is as follows:
And (3) a thickening agent: 0.2 part of EMT and 0.1 part of xanthan gum;
Preservative: 0.5 part of 1, 2-hexanediol;
Polyol: 2 parts of pentanediol and 4 parts of dipropylene glycol;
chelating agent: EDTA-2Na 0.05 parts;
emulsifying agent: 3 parts of polyglycerol-10-laurate;
grease: 10 parts of caprylic/capric triglyceride, 2 parts of squalane and 3 parts of white pool flower seed oil;
The functional components are as follows: moisture-preserving functional components: oat beta glucan 0.1 part, sodium hyaluronate 0.1 part;
The soothing efficacy component: 2 parts of oat kernel extract and 2 parts of citrus fruit extract;
70.95 parts of purified water.
The preparation method of the skin care product of the conventional emulsifying system comprises the following steps:
S1: accurately weighing the components according to the formula of the Pickering emulsion type skin care product;
S2: adding purified water into an emulsifying tank, sequentially adding an emulsifying agent, a preservative, a polyalcohol, a chelating agent and a thickening agent, heating to 80-85 ℃, keeping the stirring rotation speed at 60r/min, and stirring and dissolving for 15min to obtain a component A for later use;
s3: adding the grease and the oil-soluble active ingredients into an oil phase pre-preparing tank for a plurality of times to obtain a component B, and heating to 80-85 ℃ for standby;
S4: pumping the component B into an emulsifying tank of the component A at one time at 80-85 ℃, homogenizing at 2500rpm, homogenizing and emulsifying for 6min, and cooling by cooling water;
s5: when the temperature is reduced to 45 ℃, adding water-soluble functional components, and continuing to cool by introducing cooling water;
s6: when the temperature is reduced to 38 ℃, filtering and discharging, and filling after the inspection is qualified, thus obtaining the skin care product of the conventional emulsification system.
Comparative examples 5-7 (common pickering emulsifiers):
The common pickering emulsifying agent is as follows: the prepared skin care products of the pearl powder, the titanium dioxide and the zinc oxide are respectively corresponding to comparative example 5, comparative example 6 and comparative example 7.
The pickering emulsion skin care product comprises the following components:
0.7 part of common Pickering emulsifier;
Preservative: 0.5 part of 1, 2-hexanediol;
Polyol: 2 parts of pentanediol and 4 parts of dipropylene glycol;
chelating agent: EDTA-2Na 0.05 parts;
grease: 10 parts of caprylic/capric triglyceride, 2 parts of squalane and 3 parts of white pool flower seed oil;
The functional components are as follows: moisture-preserving functional components: oat beta glucan 0.1 part, sodium hyaluronate 0.1 part;
The soothing efficacy component: 2 parts of oat kernel extract and 2 parts of citrus fruit extract;
73.55 parts of purified water.
The preparation method of the pickering emulsion skin care product comprises the following steps:
S1: accurately weighing the components according to the formula of the Pickering emulsion type skin care product;
S2: under the normal temperature condition, adding purified water into an emulsifying tank, and then sequentially adding a common Pickering emulsifying agent, a preservative, a polyalcohol, a chelating agent and water-soluble functional components, wherein the stirring speed is kept at 60r/min, and stirring and dissolving are carried out for 15min at normal temperature to obtain a component A;
S3: under normal temperature, putting the grease and the oil-soluble active ingredients into an oil phase pre-preparing tank for a time to obtain a component B;
S4: pumping the component B into an emulsifying tank of the component A at one time under the normal temperature condition, homogenizing at 2500rpm, and homogenizing and emulsifying for 6min;
s5: and after homogenizing and emulsifying, filtering and discharging, and filling after the inspection is qualified to obtain the Pickering emulsion type skin care product.
Comparative examples 8, 9, 10 (common pickering emulsifiers (relatively stable high levels)):
the common pickering emulsifiers described in this comparative example are: the skin care products prepared by the pearl powder 2 parts, titanium dioxide 2 parts and zinc oxide 2 parts are respectively comparative example 8, comparative example 9 and comparative example 10.
A Pickering emulsion type skin care product comprises the following components in parts by weight:
2 parts of common Pickering emulsifier;
Preservative: 0.5 part of 1, 2-hexanediol;
Polyol: 2 parts of pentanediol and 4 parts of dipropylene glycol;
chelating agent: EDTA-2Na 0.05 parts;
grease: 10 parts of caprylic/capric triglyceride, 2 parts of squalane and 3 parts of white pool flower seed oil;
The functional components are as follows: moisture-preserving functional components: oat beta glucan 0.1 part, sodium hyaluronate 0.1 part;
The soothing efficacy component: 2 parts of oat kernel extract and 2 parts of citrus fruit extract;
72.25 parts of purified water.
The preparation method of the pickering emulsion skin care product comprises the following steps:
S1: accurately weighing the components according to the formula of the Pickering emulsion type skin care product;
S2: under the normal temperature condition, adding purified water into an emulsifying tank, and then sequentially adding a common Pickering emulsifying agent, a preservative, a polyalcohol, a chelating agent and water-soluble functional components, wherein the stirring speed is kept at 60r/min, and stirring and dissolving are carried out for 15min at normal temperature to obtain a component A;
S3: under normal temperature, putting the grease and the oil-soluble active ingredients into an oil phase pre-preparing tank for a time to obtain a component B;
S4: pumping the component B into an emulsifying tank of the component A at one time under the normal temperature condition, homogenizing at 2500rpm, and homogenizing and emulsifying for 6min;
s5: and after homogenizing and emulsifying, filtering and discharging, and filling after the inspection is qualified to obtain the Pickering emulsion type skin care product.
Experimental example 1: centrifugal test
8G of each of the samples of examples 1 to 3 and comparative examples 1 to 10 was taken, and the samples were incubated at 38℃for 1 hour, and then subjected to centrifugal test at 2000rpm, 3000rpm and 4000rpm, respectively, to obtain the following results:
Table 1 results of sample centrifugation test
As can be seen from table 1:
1. Comparing example 1 with example 2, it is clear that the centrifugal stability of the product is affected by the proportion of different components of the composition;
2. comparing example 1 with example 3 shows that the change of the process parameters has little effect on the centrifugal stability of the product;
3. Comparing example 1 with comparative examples 1 and 2, it is shown that the stability of the Pickering composition A, symReboot TM L19 product alone is slightly inferior, and the product centrifugal stability is good when the Pickering composition and the product centrifugal stability are compounded, so that the Pickering composition and the product centrifugal stability have good synergistic stability.
4. Comparing example 1 with comparative examples 4-10, it can be seen that the compositions of the present invention still achieve better centrifugal stability than conventional emulsifiers and conventional pickering emulsifier products at low levels, indicating that the compositions of the present invention are more emulsifying, more stable, and less costly.
Experimental example 2: three month stability test
The stability test was performed for three months under conditions of 4℃at 45℃and-18℃and cycles (-18℃at 4℃at 45℃and once every 3 days) of example 1, example 2, example 4, comparative example 5, comparative example 8 and comparative example 9 (200 g samples each) as follows:
table 2 sample stability test results
As can be seen from the above table, the data,
1. Comparing example 1 with example 2 shows that the proportion of different components of the composition has a certain effect on the conventional stability of the product;
2. Comparing example 1 with example 3 shows that the change in process parameters has little effect on the conventional stability of the product;
3. Comparing example 1 with comparative examples 1 and 2, it is shown that the conventional stability of the Pickering composition A, symReboot TM L19 product alone is slightly inferior, and the product conventional stability is good when the Pickering composition and the product are compounded, so that the Pickering composition and the product have good synergistic stability;
4. Comparing example 1 with comparative examples 4, 8-10, it is shown that the compositions of the present invention still achieve better conventional stability than conventional emulsifiers and conventional pickering emulsifier products at low levels, indicating that the compositions of the present invention are more emulsion stable and have lower levels of use.
Experimental example 3: skin moisture loss (TEWL) test
Skin moisture loss test comparative experiments were performed on example 1 and comparative examples 1 to 3:
Test instrument: the multifunctional skin tester of the Germany CK company is the probe model TEWAMETER TM.
The test principle is as follows: FICK law of diffusion: dm/dt=d.a. dp/dx. The amount of water emitted from the skin is measured directly by two sets of temperature and humidity sensors. The TEWL value is an important sign of whether the skin barrier is good or bad, and the lower the TEWL value of the skin is, the better the barrier function of the skin is, whereas the worse the skin barrier function is, the larger the reduction of the skin water loss is, and the better the effect of skin barrier repair is.
The testing method comprises the following steps: 80 dry skin groups were selected, aged 20-45 years, and randomly divided into 16 groups of 5. Any product (cosmetics, external medicines, and oral health products) cannot be used 15 days before the tested part. Prior to the test, the subjects were asked to rinse the face and enter a climate controlled chamber (22±1 ℃, 50% relative humidity) for more than 20 minutes 2 hours after rinsing and remain relaxed.
In the test, a half face test is carried out according to a random table, the left and right nasolabial folds of the volunteer are selected for water loss TEWL value test, and the average value of 3 values is taken as the data (d 0) of the water content of the left and right nasolabial folds and the data (d 0) of the water loss TEWL value of the nasolabial folds skin. After the test, the volunteers were required to use them (once in the morning and evening after cleansing) for 28 days and the testers were required to return at the test day 28 (d 28).
As shown in fig. 3, the application example 1 has a good effect of reducing the loss of skin moisture compared with the comparison examples 1 to 3, and particularly, the combination of the pickering emulsion stabilizing composition and the white pool seed oil has a certain synergistic effect, which indicates that the application example 1 has a good skin repair effect.
Experimental example 4: visia-CR facial red area analysis
A healthy female subject in China is selected with an age ranging from 30 to 40 years old. The product was continuously used for 4 weeks (D28) before the subjects used application example 1 and comparative examples 1 to 3 (D0), using the following method: after cleansing, the subjects were taken a photograph of their faces with Visia-CR, each time in the morning and evening. And performing image analysis on the red region picture acquired and derived by the VISIA-CR to obtain a facial red region analysis a. The greater the red area analysis a value, the more severe the redness of the skin. The results are shown in fig. 4, and there was a clear lightening and reduction of the red area of the face of the subject who had been applied after 28 days with the liposomal cream with repair efficacy of application example 1.
As can be seen from fig. 4, application example 1 has a good effect of reducing red areas of the skin and face compared with comparative examples 1 to 3, and in particular, the combination of the pickering emulsion stabilizing composition and the white pool seed oil has a certain synergistic effect, which indicates that example 1 has a good skin repair effect.
Claims (5)
1. The pickering emulsion type skin care product containing the pickering emulsion stabilizing composition is characterized by comprising the following components in parts by weight: 0.5-1.0 part of the Pickering emulsion stabilizing composition, 0.05-1 part of the preservative, 5-8 parts of the polyalcohol, 0.01-0.1 part of the chelating agent, 10-20 parts of the grease, 3-10 parts of the functional component and 100 parts of the purified water; the grease at least comprises 2 parts of white pool flower seed oil;
The pickering emulsion stabilizing composition comprises the following components in percentage by weight: 47.6% of microcrystalline cellulose, 16.1% of sphingomonas fermentation product extract, 6.3% of cellulose gum and SymReboot ™ L19% of water.
2. The pickering emulsion skin care product of claim 1, wherein the SymReboot ™ L19 has a particle size of 300-500nm and a regular spherical microstructure.
3. The Pickering emulsion type skin care product according to claim 1, wherein,
The preservative is as follows: one or more of the following components of the fresh ketone, the hexanediol and the phenoxyethanol;
The polyol is as follows: one or more of dipropylene glycol, glycerol, butylene glycol, and pentylene glycol;
The chelating agent is as follows: one or more of EDTA-2Na, EDTA-4Na, sodium hexametaphosphate;
The grease is as follows: one or more of dioctyl carbonate, caprylic/capric triglyceride, squalane, white pool seed oil, sunflower seed oil, silicone oil, vitamin E acetate, hydrogenated polyisobutene, isononyl isononanoate, C12-15 alcohol benzoate, malla oil, emu oil, sweet almond oil, C9-12 alkane, coco alcohol-caprylic/capric ester, polydimethylsiloxane, plant squalane, isooctyl palmitate, isopropyl myristate;
The functional components are divided into water-soluble functional components and oil-soluble functional components; the water-soluble functional components are as follows: one or more of hydrogenated lecithin, oat glucan, sodium hyaluronate, oat kernel extract, citrus fruit extract; the oil-soluble functional components are as follows: coenzyme Q10, astaxanthin, begonia seed oil, and squalane.
4. The method for preparing the pickering emulsion type skin care product as claimed in claim 3, which is characterized by comprising the following steps:
s1: weighing the components according to the formula of the Pickering emulsion skin care product;
S2: under the normal temperature condition, adding purified water into an emulsifying tank, and then sequentially adding a pickering emulsion stabilizing composition, a preservative, a polyalcohol, a chelating agent and water-soluble functional components, wherein the stirring rotation speed is kept at 10-500 r/min, and stirring and dissolving at normal temperature for 10-40 min to obtain a component A;
s3: under the normal temperature condition, putting the grease and the oil-soluble functional components into an oil phase pre-preparing tank to obtain a component B;
s4: pumping the component B into an emulsifying tank of the component A at one time under the normal temperature condition, homogenizing at 2000-5000 rpm, and homogenizing and emulsifying for 5-18 min;
s5: and after homogenizing and emulsifying, filtering and discharging, and filling after the inspection is qualified to obtain the Pickering emulsion type skin care product.
5. Use of a pick-up emulsion skin care product according to any one of claims 1 to 3 for the preparation of a skin care product for repairing skin barriers.
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| CN114146008A (en) * | 2021-11-05 | 2022-03-08 | 华熙生物科技股份有限公司 | Pickering emulsion, cleaning product and preparation method thereof |
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