CN114948841B - Pearl active ingredient oil solution, preparation method thereof and skin external agent - Google Patents
Pearl active ingredient oil solution, preparation method thereof and skin external agent Download PDFInfo
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- CN114948841B CN114948841B CN202210705083.9A CN202210705083A CN114948841B CN 114948841 B CN114948841 B CN 114948841B CN 202210705083 A CN202210705083 A CN 202210705083A CN 114948841 B CN114948841 B CN 114948841B
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- active ingredient
- pearl
- oil
- caprylic
- pearl active
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- 239000004480 active ingredient Substances 0.000 title claims abstract description 86
- 238000002360 preparation method Methods 0.000 title claims abstract description 53
- 239000003921 oil Substances 0.000 claims abstract description 68
- WWZKQHOCKIZLMA-UHFFFAOYSA-N octanoic acid Chemical compound CCCCCCCC(O)=O WWZKQHOCKIZLMA-UHFFFAOYSA-N 0.000 claims abstract description 55
- 239000000341 volatile oil Substances 0.000 claims abstract description 37
- 239000000592 Artificial Cell Substances 0.000 claims abstract description 30
- 210000000170 cell membrane Anatomy 0.000 claims abstract description 25
- LEACJMVNYZDSKR-UHFFFAOYSA-N 2-octyldodecan-1-ol Chemical compound CCCCCCCCCCC(CO)CCCCCCCC LEACJMVNYZDSKR-UHFFFAOYSA-N 0.000 claims abstract description 19
- BTFJIXJJCSYFAL-UHFFFAOYSA-N arachidyl alcohol Natural products CCCCCCCCCCCCCCCCCCCCO BTFJIXJJCSYFAL-UHFFFAOYSA-N 0.000 claims abstract description 19
- 239000002994 raw material Substances 0.000 claims abstract description 19
- 125000005456 glyceride group Chemical group 0.000 claims abstract description 17
- XDOFQFKRPWOURC-UHFFFAOYSA-N 16-methylheptadecanoic acid Chemical compound CC(C)CCCCCCCCCCCCCCC(O)=O XDOFQFKRPWOURC-UHFFFAOYSA-N 0.000 claims abstract description 16
- LADGBHLMCUINGV-UHFFFAOYSA-N tricaprin Chemical compound CCCCCCCCCC(=O)OCC(OC(=O)CCCCCCCCC)COC(=O)CCCCCCCCC LADGBHLMCUINGV-UHFFFAOYSA-N 0.000 claims abstract description 12
- 235000019198 oils Nutrition 0.000 claims description 61
- 230000003078 antioxidant effect Effects 0.000 claims description 30
- 239000003963 antioxidant agent Substances 0.000 claims description 29
- 239000000203 mixture Substances 0.000 claims description 21
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 15
- 239000005635 Caprylic acid (CAS 124-07-2) Substances 0.000 claims description 11
- 229960002446 octanoic acid Drugs 0.000 claims description 11
- 239000000126 substance Substances 0.000 claims description 11
- 239000000843 powder Substances 0.000 claims description 10
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 claims description 9
- ZAKOWWREFLAJOT-CEFNRUSXSA-N D-alpha-tocopherylacetate Chemical group CC(=O)OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C ZAKOWWREFLAJOT-CEFNRUSXSA-N 0.000 claims description 9
- 229910052791 calcium Inorganic materials 0.000 claims description 9
- 239000011575 calcium Substances 0.000 claims description 9
- 108010006161 conchiolin Proteins 0.000 claims description 9
- 150000003626 triacylglycerols Chemical class 0.000 claims description 9
- 238000000034 method Methods 0.000 claims description 8
- 238000002156 mixing Methods 0.000 claims description 8
- ZAKOWWREFLAJOT-UHFFFAOYSA-N d-alpha-Tocopheryl acetate Natural products CC(=O)OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C ZAKOWWREFLAJOT-UHFFFAOYSA-N 0.000 claims description 6
- FOYKKGHVWRFIBD-UHFFFAOYSA-N gamma-tocopherol acetate Natural products CC(=O)OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1 FOYKKGHVWRFIBD-UHFFFAOYSA-N 0.000 claims description 6
- 239000004519 grease Substances 0.000 claims description 6
- PRAKJMSDJKAYCZ-UHFFFAOYSA-N squalane Chemical compound CC(C)CCCC(C)CCCC(C)CCCCC(C)CCCC(C)CCCC(C)C PRAKJMSDJKAYCZ-UHFFFAOYSA-N 0.000 claims description 6
- 235000015112 vegetable and seed oil Nutrition 0.000 claims description 6
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 claims description 5
- BAECOWNUKCLBPZ-HIUWNOOHSA-N Triolein Natural products O([C@H](OCC(=O)CCCCCCC/C=C\CCCCCCCC)COC(=O)CCCCCCC/C=C\CCCCCCCC)C(=O)CCCCCCC/C=C\CCCCCCCC BAECOWNUKCLBPZ-HIUWNOOHSA-N 0.000 claims description 4
- PHYFQTYBJUILEZ-UHFFFAOYSA-N Trioleoylglycerol Natural products CCCCCCCCC=CCCCCCCCC(=O)OCC(OC(=O)CCCCCCCC=CCCCCCCCC)COC(=O)CCCCCCCC=CCCCCCCCC PHYFQTYBJUILEZ-UHFFFAOYSA-N 0.000 claims description 4
- PHYFQTYBJUILEZ-IUPFWZBJSA-N triolein Chemical compound CCCCCCCC\C=C/CCCCCCCC(=O)OCC(OC(=O)CCCCCCC\C=C/CCCCCCCC)COC(=O)CCCCCCC\C=C/CCCCCCCC PHYFQTYBJUILEZ-IUPFWZBJSA-N 0.000 claims description 4
- 229940117972 triolein Drugs 0.000 claims description 4
- KZRXPHCVIMWWDS-AWEZNQCLSA-N (4S)-4-amino-5-dodecanoyloxy-5-oxopentanoic acid Chemical compound CCCCCCCCCCCC(=O)OC(=O)[C@@H](N)CCC(O)=O KZRXPHCVIMWWDS-AWEZNQCLSA-N 0.000 claims description 3
- WHBKVWBGTBULQY-UHFFFAOYSA-N 2-propylheptyl octanoate Chemical compound CCCCCCCC(=O)OCC(CCC)CCCCC WHBKVWBGTBULQY-UHFFFAOYSA-N 0.000 claims description 3
- 240000001548 Camellia japonica Species 0.000 claims description 3
- 235000018597 common camellia Nutrition 0.000 claims description 3
- 239000008169 grapeseed oil Substances 0.000 claims description 3
- 229940071085 lauroyl glutamate Drugs 0.000 claims description 3
- 239000008176 lyophilized powder Substances 0.000 claims description 3
- JXTPJDDICSTXJX-UHFFFAOYSA-N n-Triacontane Natural products CCCCCCCCCCCCCCCCCCCCCCCCCCCCCC JXTPJDDICSTXJX-UHFFFAOYSA-N 0.000 claims description 3
- 229940032094 squalane Drugs 0.000 claims description 3
- 235000020238 sunflower seed Nutrition 0.000 claims description 3
- GHVNFZFCNZKVNT-UHFFFAOYSA-M decanoate Chemical compound CCCCCCCCCC([O-])=O GHVNFZFCNZKVNT-UHFFFAOYSA-M 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 239000002537 cosmetic Substances 0.000 abstract description 15
- 238000005282 brightening Methods 0.000 abstract description 11
- 230000000694 effects Effects 0.000 abstract description 9
- 230000007794 irritation Effects 0.000 abstract description 3
- 231100000956 nontoxicity Toxicity 0.000 abstract description 3
- 206010067484 Adverse reaction Diseases 0.000 abstract description 2
- 230000006838 adverse reaction Effects 0.000 abstract description 2
- 239000011049 pearl Substances 0.000 description 99
- 239000000243 solution Substances 0.000 description 61
- 210000003491 skin Anatomy 0.000 description 44
- 238000003756 stirring Methods 0.000 description 24
- 238000012360 testing method Methods 0.000 description 22
- 239000005632 Capric acid (CAS 334-48-5) Substances 0.000 description 6
- GHVNFZFCNZKVNT-UHFFFAOYSA-N Decanoic acid Natural products CCCCCCCCCC(O)=O GHVNFZFCNZKVNT-UHFFFAOYSA-N 0.000 description 6
- 230000000052 comparative effect Effects 0.000 description 6
- 238000010438 heat treatment Methods 0.000 description 6
- 239000007864 aqueous solution Substances 0.000 description 5
- 239000000284 extract Substances 0.000 description 5
- 230000002829 reductive effect Effects 0.000 description 5
- 231100000274 skin absorption Toxicity 0.000 description 5
- SOGAXMICEFXMKE-UHFFFAOYSA-N Butylmethacrylate Chemical compound CCCCOC(=O)C(C)=C SOGAXMICEFXMKE-UHFFFAOYSA-N 0.000 description 4
- 238000001816 cooling Methods 0.000 description 4
- 238000010586 diagram Methods 0.000 description 4
- 239000004615 ingredient Substances 0.000 description 4
- BHPQYMZQTOCNFJ-UHFFFAOYSA-N Calcium cation Chemical compound [Ca+2] BHPQYMZQTOCNFJ-UHFFFAOYSA-N 0.000 description 3
- 230000009286 beneficial effect Effects 0.000 description 3
- 229910001424 calcium ion Inorganic materials 0.000 description 3
- 238000009792 diffusion process Methods 0.000 description 3
- XJFGDLJQUJQUEI-UHFFFAOYSA-N dodecyl decanoate dodecyl octanoate Chemical compound CCCCCCCCCCCCOC(=O)CCCCCCC.CCCCCCCCCCCCOC(=O)CCCCCCCCC XJFGDLJQUJQUEI-UHFFFAOYSA-N 0.000 description 3
- 238000005286 illumination Methods 0.000 description 3
- 238000009776 industrial production Methods 0.000 description 3
- 239000000463 material Substances 0.000 description 3
- -1 methylpropanoxyethyl phosphorylcholine-n-butyl methacrylate Chemical compound 0.000 description 3
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- 230000037384 skin absorption Effects 0.000 description 3
- 229940042585 tocopherol acetate Drugs 0.000 description 3
- 230000002087 whitening effect Effects 0.000 description 3
- XUMBMVFBXHLACL-UHFFFAOYSA-N Melanin Chemical compound O=C1C(=O)C(C2=CNC3=C(C(C(=O)C4=C32)=O)C)=C2C4=CNC2=C1C XUMBMVFBXHLACL-UHFFFAOYSA-N 0.000 description 2
- 238000010521 absorption reaction Methods 0.000 description 2
- 230000032683 aging Effects 0.000 description 2
- 230000003712 anti-aging effect Effects 0.000 description 2
- 244000309466 calf Species 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 230000003020 moisturizing effect Effects 0.000 description 2
- 150000003904 phospholipids Chemical group 0.000 description 2
- 238000001556 precipitation Methods 0.000 description 2
- 238000004321 preservation Methods 0.000 description 2
- 231100000245 skin permeability Toxicity 0.000 description 2
- 238000013112 stability test Methods 0.000 description 2
- 210000000434 stratum corneum Anatomy 0.000 description 2
- UIVPNOBLHXUKDX-UHFFFAOYSA-N 3,5,5-trimethylhexyl 3,5,5-trimethylhexanoate Chemical compound CC(C)(C)CC(C)CCOC(=O)CC(C)CC(C)(C)C UIVPNOBLHXUKDX-UHFFFAOYSA-N 0.000 description 1
- 241000700198 Cavia Species 0.000 description 1
- 244000293323 Cosmos caudatus Species 0.000 description 1
- 235000005956 Cosmos caudatus Nutrition 0.000 description 1
- 206010013786 Dry skin Diseases 0.000 description 1
- 102000002045 Endothelin Human genes 0.000 description 1
- 108050009340 Endothelin Proteins 0.000 description 1
- 206010015150 Erythema Diseases 0.000 description 1
- 206010067482 No adverse event Diseases 0.000 description 1
- 206010030113 Oedema Diseases 0.000 description 1
- 206010039792 Seborrhoea Diseases 0.000 description 1
- 206010040880 Skin irritation Diseases 0.000 description 1
- 230000001154 acute effect Effects 0.000 description 1
- 150000001413 amino acids Chemical class 0.000 description 1
- 230000003042 antagnostic effect Effects 0.000 description 1
- 230000004888 barrier function Effects 0.000 description 1
- 230000003796 beauty Effects 0.000 description 1
- 235000013361 beverage Nutrition 0.000 description 1
- 238000000876 binomial test Methods 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 229910000019 calcium carbonate Inorganic materials 0.000 description 1
- 210000004027 cell Anatomy 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 239000003153 chemical reaction reagent Substances 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 229920001577 copolymer Polymers 0.000 description 1
- 230000008021 deposition Effects 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 230000018109 developmental process Effects 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 230000037336 dry skin Effects 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 230000001804 emulsifying effect Effects 0.000 description 1
- ZUBDGKVDJUIMQQ-UBFCDGJISA-N endothelin-1 Chemical compound C([C@@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(O)=O)NC(=O)[C@H]1NC(=O)[C@H](CC=2C=CC=CC=2)NC(=O)[C@@H](CC=2C=CC(O)=CC=2)NC(=O)[C@H](C(C)C)NC(=O)[C@H]2CSSC[C@@H](C(N[C@H](CO)C(=O)N[C@@H](CO)C(=O)N[C@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)N[C@H](CC(O)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(O)=O)C(=O)N2)=O)NC(=O)[C@@H](CO)NC(=O)[C@H](N)CSSC1)C1=CNC=N1 ZUBDGKVDJUIMQQ-UBFCDGJISA-N 0.000 description 1
- 210000001339 epidermal cell Anatomy 0.000 description 1
- 231100000321 erythema Toxicity 0.000 description 1
- 230000001815 facial effect Effects 0.000 description 1
- 230000002349 favourable effect Effects 0.000 description 1
- 210000005260 human cell Anatomy 0.000 description 1
- 239000000017 hydrogel Substances 0.000 description 1
- 230000002209 hydrophobic effect Effects 0.000 description 1
- 125000001165 hydrophobic group Chemical group 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- 229940100554 isononyl isononanoate Drugs 0.000 description 1
- 230000000670 limiting effect Effects 0.000 description 1
- 150000002632 lipids Chemical class 0.000 description 1
- 239000002932 luster Substances 0.000 description 1
- 239000002075 main ingredient Substances 0.000 description 1
- 230000008099 melanin synthesis Effects 0.000 description 1
- 239000012528 membrane Substances 0.000 description 1
- 238000012544 monitoring process Methods 0.000 description 1
- 230000037312 oily skin Effects 0.000 description 1
- 239000000419 plant extract Substances 0.000 description 1
- 229920000642 polymer Polymers 0.000 description 1
- 229920001184 polypeptide Polymers 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 102000004196 processed proteins & peptides Human genes 0.000 description 1
- 125000001453 quaternary ammonium group Chemical class 0.000 description 1
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- 210000001519 tissue Anatomy 0.000 description 1
- 235000013619 trace mineral Nutrition 0.000 description 1
- 239000011573 trace mineral Substances 0.000 description 1
- 230000000007 visual effect Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/98—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin
- A61K8/987—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin of species other than mammals or birds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/0204—Specific forms not provided for by any of groups A61K8/0208 - A61K8/14
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/37—Esters of carboxylic acids
- A61K8/375—Esters of carboxylic acids the alcohol moiety containing more than one hydroxy group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
- A61K8/678—Tocopherol, i.e. vitamin E
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/81—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions involving only carbon-to-carbon unsaturated bonds
- A61K8/8141—Compositions of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by only one carboxyl radical, or of salts, anhydrides, esters, amides, imides or nitriles thereof; Compositions of derivatives of such polymers
- A61K8/8152—Homopolymers or copolymers of esters, e.g. (meth)acrylic acid esters; Compositions of derivatives of such polymers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/10—General cosmetic use
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/20—Chemical, physico-chemical or functional or structural properties of the composition as a whole
- A61K2800/26—Optical properties
- A61K2800/262—Transparent; Translucent
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/60—Particulates further characterized by their structure or composition
- A61K2800/61—Surface treated
- A61K2800/62—Coated
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Zoology (AREA)
- Emergency Medicine (AREA)
- Dermatology (AREA)
- Cosmetics (AREA)
Abstract
The invention discloses a pearl active ingredient oil solution, a preparation method thereof and an external skin preparation, and belongs to the technical field of external skin preparations. The preparation raw materials of the pearl active ingredient oil solution comprise the following components in percentage by weight: 0.9-1.1% of artificial cell membrane, 39-58% of octyl dodecanol isostearate, 4-12% of caprylic/capric triglyceride and 0.9-1.1% of pearl active ingredient, and the balance of caprylic/capric glyceride. The pearl active ingredient oil solution is clear and transparent oil solution, has good safety and no toxicity and irritation, and can realize the application of the pearl active ingredient in the full-oil formula cosmetics. The skin external preparation, especially the essential oil, has good brightening effect, and can improve skin state after use without adverse reaction. The preparation method of the pearl active ingredient oil solution is simple and convenient to operate.
Description
Technical Field
The invention relates to the technical field of skin external preparations, in particular to a pearl active ingredient oil solution and a preparation method thereof, and a skin external preparation.
Background
The essential oil is an oily skin care product, is suitable for dry skin or dry seasons, can help soften skin, prevent skin from drying, and promote the moistening property and efficacy of the skin care product. The essential oil product with the effects of brightening and resisting aging is a hot spot for market development, and is more suitable for aged skin with reduced grease secretion compared with other products, but the existing essential oil is still to be improved in the aspect of efficacy, one of the reasons is that an essential oil formula system requires better oil solubility of active ingredients, but a plurality of active matters, particularly plant extracts, belong to water-soluble ingredients, are difficult to dissolve or stably disperse in the essential oil, are more difficult to prepare into full transparent essential oil, and the skin absorption and utilization rate of the active ingredients are low, so that the efficacy of the essential oil cannot be fully exerted. In addition, compared with opaque essential oil, the full transparent essential oil has better flowability, fresh and non-greasy skin feel, and can feel purer in visual effect, thereby being favored by consumers.
The pearl is an oral and external traditional Chinese medicine with thousands of years of traditional beauty application history, contains various microelements, amino acid and peptide active ingredients, inhibits the formation of melanin, is beneficial to brightening skin color and keeping the skin white, can provide nourishing and whitening effects for the skin, but is difficult to stably exist and be absorbed in oil cosmetics, particularly transparent essential oil.
In view of this, the present invention has been made.
Disclosure of Invention
The invention aims to provide a pearl active ingredient oil solution for solving the technical problems.
The second purpose of the invention is to provide a preparation method of the pearl active ingredient oil solution.
The third object of the present invention is to provide a skin external preparation comprising the above-mentioned pearl active ingredient oil solution as a raw material.
The application can be realized as follows:
In a first aspect, the present application provides a pearl active ingredient oil solution, which is prepared from the following raw materials in percentage by weight: 0.9-1.1% of artificial cell membrane, 39-58% of octyl dodecanol isostearate, 4-12% of caprylic/capric triglyceride and 0.9-1.1% of pearl active ingredient, and the balance of caprylic/capric glyceride.
In an alternative embodiment, the pearl active ingredient comprises at least one of water-soluble pearl powder, hydrolyzed pearl lyophilized powder, hydrolyzed conchiolin, and pearl young factor.
In alternative embodiments, the physical and chemical parameters of the pearl active ingredient include: the water content is 0.1-7wt% and the calcium content is 10-17wt%; and the pH value of the pearl active ingredient solution after the pearl active ingredient and water are dissolved according to the weight ratio of 1:9 is 5.5-7.0.
In an alternative embodiment, the artificial cell membrane is polyquaternium-51.
In an alternative embodiment, the preparation further comprises 0.5-1% of an antioxidant, by weight percent of the same as the active ingredient of the pearl.
In an alternative embodiment, the antioxidant is an oil soluble antioxidant.
In an alternative embodiment, the oil soluble antioxidant is tocopheryl acetate.
In a second aspect, the present application provides a method for preparing a pearl active ingredient oil solution according to any of the preceding embodiments, comprising the steps of: mixing the preparation raw materials according to the proportion.
In an alternative embodiment, the preparation comprises: mixing artificial cell membrane, pearl active ingredient and octyl dodecanol isostearate to obtain a first component;
caprylic/capric glycerides, caprylic/capric triglycerides, are mixed with the first component.
In an alternative embodiment, when the preparation contains an antioxidant, the mixture of caprylic/capric glycerides, caprylic/capric triglycerides, and the first component is mixed with the antioxidant.
In a third aspect, the present application provides a skin external preparation, the raw materials for preparing the skin external preparation comprising the pearl active ingredient oil solution according to any one of the preceding embodiments.
In an alternative embodiment, the skin external preparation includes a cosmetic.
In an alternative embodiment, the cosmetic is an oil-type cosmetic.
In an alternative embodiment, the oil-based cosmetic is a clear essential oil.
In an alternative embodiment, the transparent clear essential oil is prepared from, by mass, 0.01-10% of a skin protectant, 0.1-2% of an oil-soluble antioxidant, and 0.1-10% of the pearl active ingredient oil solution of any one of the preceding embodiments, with the balance being medium-low polarity grease.
In an alternative embodiment, the medium and low polarity lipid comprises at least one of coco-caprylate/caprate, propyl heptyl caprylate, phytosterol/octyldodecanol lauroyl glutamate, caprylic/capric glycerides, caprylic/capric triglycerides, triolein, white pool seed oil, squalane, grape seed oil, camellia seed oil, and sunflower seed oil.
The beneficial effects of the application include:
according to the application, the oil-insoluble pearl active ingredient is entrapped with the artificial cell membrane according to a reasonable proportion and then is dissolved in the oil phase according to a specific proportion to prepare the clear and transparent oil solution, so that the formula is convenient to apply, and the formula has good skin permeability, absorption and utilization rate, good safety and no toxicity or irritation, and can realize the skin care effects of brightening and improving the skin state when being applied to essential oil.
The preparation process of the pearl active ingredient oil solution is simple, the operation is convenient, and the method is suitable for industrial production.
Drawings
In order to more clearly illustrate the technical solutions of the embodiments of the present invention, the drawings that are needed in the embodiments will be briefly described below, it being understood that the following drawings only illustrate some embodiments of the present invention and therefore should not be considered as limiting the scope, and other related drawings may be obtained according to these drawings without inventive effort for a person skilled in the art.
FIG. 1 is a diagram showing the state of the product of the artificial cell membrane-entrapped pearl young factor oil solution of example 1 of the present application;
FIG. 2 is a diagram showing the state of the product of the artificial cell membrane-entrapped water-soluble pearl powder oil solution of example 1 of the present application;
FIG. 3 is a product state diagram of a cloudy solution of non-entrapped pearl active ingredient of comparative example 1 of the present application;
Fig. 4 is a product state diagram of essential oil corresponding to comparative example 2 of the present application.
Detailed Description
In order to make the objects, technical solutions and advantages of the embodiments of the present invention more clear, the technical solutions of the embodiments of the present invention will be clearly and completely described below. The specific conditions are not noted in the examples and are carried out according to conventional conditions or conditions recommended by the manufacturer. The reagents or apparatus used were conventional products commercially available without the manufacturer's attention.
The pearl active ingredient oil solution, the preparation method thereof and the skin external preparation provided by the application are specifically described below.
The inventors propose: in the prior art, the key reason that the pearl active ingredient is difficult to stably exist and be absorbed in the oil cosmetics, especially transparent essential oil, is that the main ingredient calcium carbonate of the pearl powder is insoluble in water and oil, other trace elements and peptide active ingredients are all water-soluble ingredients, the solubility in the oil is extremely low, and the stability of the product can be greatly reduced when the pearl active ingredient is added into the oil cosmetic formula.
Based on the above, the application creatively provides a pearl active ingredient oil solution, which is prepared from the following raw materials in percentage by weight: 0.9-1.1% of artificial cell membrane, 39-58% of octyl dodecanol isostearate, 4-12% of caprylic/capric triglyceride and 0.9-1.1% of pearl active ingredient, and the balance of caprylic/capric glyceride.
Through the preparation raw materials, after the non-oil-soluble pearl active ingredients are entrapped with artificial cell membranes, the non-oil-soluble pearl active ingredients are dissolved in an oil phase formed by caprylic/capric triglyceride, octyl dodecanol isostearate and caprylic/capric glyceride according to a specific proportion to prepare clear and transparent oil solution, so that the water-soluble pearl ingredients are converted into oil-soluble pearl entrapped matters.
In the application, the pearl active ingredient comprises at least one of water-soluble pearl powder, hydrolyzed pearl lyophilized powder, hydrolyzed conchiolin and pearl young factor.
The hydrolyzed conchiolin is a whitening essence component derived from pearl of the Shi-diffusion group Deqing biotechnology Co., ltd. Of Zhejiang and Europe, contains proper small molecular polypeptide, is favorable for inhibiting skin melanin production, has the activity of antagonizing endothelin, effectively resists skin color deposition, and can be used for whitening, brightening and spot-lightening cosmetics.
The pearl young factor refers to an anti-aging essence component derived from pearls of the Zhejiang Europe and Shi diffusion group Deqing biotechnology limited company, is beneficial to the growth of skin epidermal cells, effectively resists the aging of cells, and can be used for anti-aging, brightening and repairing cosmetics.
In a preferred embodiment, the physical and chemical parameters of the pearl active ingredient used in the present application include: the water content is 0.1-7wt% and the calcium content is 10-17wt%; and the pH value of the pearl active ingredient solution after the pearl active ingredient and water are dissolved according to the weight ratio of 1:9 is 5.5-7.0.
Wherein the water content of the pearl active ingredient may be 0.1wt%, 0.5wt%, 1wt%, 1.5wt%, 2wt%, 2.5wt%, 3wt%, 3.5wt%, 4wt%, 4.5wt%, 5wt%, 5.5wt%, 6wt%, 6.5wt% or 7wt%, etc., and may be any other value within the range of 0.1 to 7 wt%.
The calcium content of the pearl active ingredient may be 10wt%, 11wt%, 12wt%, 13wt%, 14wt%, 15wt%, 16wt% or 17wt%, etc., or may be any other value within the range of 10 to 17 wt%.
The pH value of the pearl active ingredient solution obtained by dissolving the pearl active ingredient and water according to the weight ratio of 1:9 can be 5.5, 5.8, 6, 6.2, 6.5, 6.8 or 7.0, etc., and can be any other value in the range of 5.5-7.0.
The pearl active ingredient with the physical and chemical parameter range is used as a preparation raw material, and can be mixed with other preparation raw materials to form stable and transparent oil solution. It should be noted that, the water content and the pH value of the raw materials in the ingredients and the calcium ion content are key influencing factors, the water content and the calcium ion content are higher, the pH value is higher or lower, the binding capacity of the pearl active ingredient and the artificial cell membrane is reduced, the stability of the oil solution is destroyed, if problems such as precipitation and turbidity occur, a clear and transparent oil solution cannot be formed, and only the pearl active ingredient with lower water content, calcium ion content and moderate pH value can form stronger binding capacity with the artificial cell membrane, thereby forming the clear and transparent oil solution.
In the present application, the artificial cell membrane is preferably polyquaternium-51.
The poly quaternary ammonium salt-51 is also called methylpropanoxyethyl phosphorylcholine-n-butyl methacrylate, and is a copolymer formed by 2-methacryloyl hydroxyethyl phosphatidylcholine and monomeric hydrophobic butyl methacrylate. Polyquaternium-51 has the same amphipathic phospholipid structure as human cell membranes, and has the film forming function of a hydrogel film of phospholipid polymer and the binding function of butyl methacrylate to lipophilic substances generated by hydrophobic groups.
According to the application, the oil-insoluble pearl active ingredient is entrapped in the bilayer of the pearl active ingredient through the polyquaternium-51, so that after the substance is smeared on the surface of skin, a biomembrane similar to a stratum corneum can be formed, which is equivalent to a barrier for the skin, and meanwhile, the pearl active ingredient has the effects of helping the stratum corneum to repair and moisturize, and can improve the rough state of the skin, smooth and fine skin.
In the present application, the artificial cell membrane may be used in an amount of 0.9%, 0.95%, 1%, 1.05% or 1.1%, etc., or any other value within the range of 0.9 to 1.1%.
The octyl dodecanol isostearate may be used in an amount of 39%, 40%, 42%, 45%, 48%, 50%, 52%, 55% or 58%, etc., or any other value within the range of 39-58%.
The amount of caprylic/capric triglyceride may be 4%, 5%, 6%, 7%, 8%, 9%, 10%, 11% or 12%, etc., or any other value within the range of 4-12%.
The amount of the pearl active ingredient may be 0.9%, 0.95%, 1%, 1.05% or 1.1%, etc., or may be any other value within the range of 0.9 to 1.1%.
According to the application, the oil-insoluble pearl active ingredient is entrapped with the artificial cell membrane according to a reasonable proportion and then is dissolved in the oil phase according to a specific proportion to prepare the clear and transparent oil solution, so that the formula is convenient to apply, and the formula has good skin permeability and absorption utilization rate, can be applied to essential oil, and can realize the effect of brightening skin.
Further, the raw materials for preparing the pearl active ingredient oil solution also comprise 0.5-1% of antioxidant according to the same weight percentage as the pearl active ingredient. Under the condition, the dosage of the caprylic/capric glyceride is 100 percent minus the weight percentage of the active ingredients of the artificial cell membrane, the octyl dodecanol isostearate, the caprylic/capric triglyceride and the pearl.
In the present application, the above-mentioned antioxidant is an oil-soluble antioxidant such as tocopheryl acetate.
By adding the oil-soluble antioxidant, the antioxidant effect of the oil solution of pearl active ingredient can be improved.
In the specific preparation process, other components which do not affect the solubility and stability of the pearl active ingredient can be added into the preparation raw materials of the pearl active ingredient oil solution according to the requirements.
Correspondingly, the application also provides a preparation method of the pearl active ingredient oil solution, which comprises the following steps: mixing the preparation raw materials according to the proportion.
Specifically, the preparation may include:
Mixing artificial cell membrane, pearl active ingredient and octyl dodecanol isostearate to obtain a first component;
caprylic/capric glycerides, caprylic/capric triglycerides, are mixed with the first component.
When the preparation material contains an antioxidant, a mixture of caprylic/capric glycerides, caprylic/capric triglycerides and a first component is mixed with the antioxidant.
The above artificial cell membrane, pearl active ingredient and octyl dodecanol isostearate may be mixed as follows: adding the above three materials into a stirring pot, heating to 40-60deg.C (40 deg.C, 50 deg.C or 60 deg.C), stirring for 25-35min (30 min) to obtain a mixture, and keeping the temperature for use.
The mixing of caprylic/capric glycerides, caprylic/capric triglycerides with the first component may be: and adding caprylic acid/capric acid glycerides and caprylic acid/capric acid triglycerides into the first component for heat preservation and standby, and continuing heat preservation and stirring until the components are completely dissolved to form a clear and transparent solution.
The addition of the antioxidant may be: and (3) after the clear and transparent solution is cooled to room temperature, adding an antioxidant and uniformly stirring.
The preparation method has simple process and convenient operation, and is suitable for industrial production.
In addition, the application also provides a skin external preparation, and the raw materials for preparing the skin external preparation comprise the pearl active ingredient oil solution.
For reference, the external preparation for skin includes cosmetics, and may be a pharmaceutical external preparation for skin, etc.
The cosmetic is oil-type cosmetic, such as essential oil (preferably clear transparent essential oil).
For reference, the transparent clear essential oil may be prepared from 0.01-10% (e.g., 0.01%, 0.05%, 0.1%, 0.5%, 1%, 2%, 5%, 8% or 10%, etc.) of skin protectant, 0.1-2% (e.g., 0.1%, 0.5%, 1%, 1.5% or 2%, etc.) of oil-soluble antioxidant, and 0.1-10% (e.g., 0.1%, 0.5%, 1%, 2%, 5%, 8% or 10%, etc.) of the above-mentioned pearl active ingredient oil solution, with the balance being medium-low polarity oil.
The medium-low polarity grease may include, by way of example and not limitation, at least one of coco-caprylate/caprate, propyl heptyl caprylate, phytosterol/octyldodecanol lauroyl glutamate, caprylic/capric glycerides, caprylic/capric triglycerides, triolein (triolein), white pool seed oil, squalane, grape seed oil, camellia seed oil, and sunflower seed oil.
In addition, the skin protectant and the oil-soluble antioxidant may be prepared from related materials commonly used in the cosmetic field, and are not limited thereto.
On the premise of bearing, the clear transparent essential oil prepared by the pearl active ingredient oil solution provided by the application has higher skin absorption and utilization rate, can achieve good brightening effect, and can improve the skin state after being used without adverse reaction.
The features and capabilities of the present invention are described in further detail below in connection with the examples.
Example 1
Preparation of oil solution of pearl active ingredient
① Preparation of hydrolyzed conchiolin oil solution entrapped by artificial cell membrane
Step (1): adding polyquaternium-51, hydrolyzed conchiolin and octyl dodecanol isostearate into a stirring pot according to the proportion shown in the table 1, heating to 40 ℃, stirring uniformly for 30min to form a mixture, and preserving heat for later use.
The hydrolyzed conchiolin is purchased from Deqing biotechnology limited company of Zhejiang Europe poetry diffusion group, and the physical and chemical parameters of the hydrolyzed conchiolin are as follows: the pH value is 6.1 (10% aqueous solution prepared by water according to the weight ratio of 1:9 is used for testing, the following is the same), the water content is 1.4%, and the calcium content is 13.0%.
Step (2): adding caprylic acid/capric acid glyceride and caprylic acid/capric acid triglyceride into the mixture in the step (1), and continuing to keep the temperature and stirring until the mixture is completely dissolved to form a clear and transparent solution.
Step (3): cooling to room temperature, adding oil-soluble antioxidant tocopherol acetate, and stirring to obtain artificial cell membrane-entrapped hydrolyzed conchiolin oil solution (i.e. oil-soluble Margarita A in Table 1).
② Preparation of artificial cell membrane-coated pearl young factor oil solution
Step (1): adding polyquaternium-51, pearl young factor and octyl dodecanol isostearate into a stirring pot according to the proportion shown in the table 1, heating to 60 ℃, stirring uniformly for 30min to form a mixture, and preserving heat for later use.
The pearl young factors are purchased from Deqing biotechnology limited company of Zhejiang Europe poem diffuse group, and the physical and chemical parameters of the pearl young factors are as follows: the pH value was 6.35 (10% aqueous solution), the moisture content was 4.1%, and the calcium content was 16.8%.
Step (2): adding caprylic acid/capric acid glyceride and caprylic acid/capric acid triglyceride into the mixture in the step (1), and continuing to keep the temperature and stirring until the mixture is completely dissolved to form a clear and transparent solution.
Step (3): cooling to room temperature, adding oil-soluble antioxidant tocopherol acetate, and stirring to obtain clear and transparent artificial cell membrane-coated Margarita young factor oil solution (i.e. oil-soluble Margarita B in Table 1) as shown in figure 1.
③ Preparation of water-soluble pearl powder oil solution coated by artificial cell membrane
Step (1): adding polyquaternium-51, water-soluble pearl powder and octyl dodecanol isostearate into a stirring pot according to the proportion shown in the table 1, heating to 50 ℃, stirring uniformly for 30min to form a mixture, and preserving heat for later use.
The water-soluble pearl powder is purchased from Deqing biotechnology limited company of Zhejiang Europe poem diffuse group, and the physical and chemical parameters of the water-soluble pearl powder are as follows: the pH value was 6.5 (10% aqueous solution), the moisture content was 1.6% and the calcium content was 14.5%.
Step (2): adding caprylic acid/capric acid glyceride and caprylic acid/capric acid triglyceride into the mixture in the step (1), and continuing to keep the temperature and stirring until the mixture is completely dissolved to form a clear and transparent solution.
Step (3): cooling to room temperature, adding oil-soluble antioxidant tocopherol acetate, and stirring to obtain clear and transparent water-soluble pearl powder oil solution (i.e. oil-soluble pearl C in table 1) coated with artificial cell membrane, as shown in figure 2.
TABLE 1 composition and composition Table
Comparative example 1
Preparation of non-entrapped pearl active ingredient cloudy solution
Step (1): adding polyquaternium-51, pearl extract and octyl dodecanol isostearate into a stirring pot according to the proportion shown in the table 2, heating to 50 ℃, stirring uniformly for 30min to form a mixture, and preserving heat for later use.
The pearl extract is purchased from Deqing biotechnology limited company of Zhejiang Europe and poem, and the physical and chemical parameters of the pearl extract are as follows: the pH value was 7.1 (10% aqueous solution), the moisture content was 7.5% and the calcium content was 19.2%.
Step (2): adding caprylic acid/capric acid glyceride and caprylic acid/capric acid triglyceride into the mixture obtained in the step (1), and continuing to keep the temperature and stir, wherein the mixture cannot be completely dissolved, and the solution is in a turbid state, so that entrapment cannot be formed.
Step (3): cooling to room temperature, adding oil-soluble antioxidant tocopheryl acetate, stirring, and making into comparative solution, wherein the solutions are all in turbid state, and cannot form clear transparent solution, as shown in figure 3.
TABLE 2 composition and composition Table
| Component name | Mass percent (%) |
| Polyquaternium-51 | 1 |
| Pearl extract | 1 |
| Octyl dodecanol isostearate | 50 |
| Caprylic/capric glycerides | To 100 |
| Caprylic/capric triglyceride | 8 |
| Tocopheryl acetate | 1 |
As can be seen from the results of fig. 2 and 3:
FIG. 2 corresponds to the oil-soluble pearl C of example 1, which is a clear transparent solution; the pearl solution in the comparative example shown in FIG. 3 was cloudy, and a clear and transparent solution could not be formed.
In addition, other pearl extracts having pH values of 7.0 (without containing) -7.2 (10% aqueous solution), moisture contents of 7.1-9.0% and calcium contents of 18-20% were used to prepare pearl active ingredient oil solutions according to the above steps and conditions, and as a result, the obtained pearl solutions were likewise shown to be in a cloudy state, and a clear and transparent solution could not be formed.
From this, it can be derived that: only if the physical and chemical parameters of the pearl active ingredient are within the scope of the application, and the preparation raw materials are prepared according to a specific proportion, the clear and transparent artificial cell membrane-coated pearl active ingredient oil solution can be formed.
Example 2
Preparation of essential oil
The oil-soluble pearl B of the artificial cell membrane-entrapped pearl active ingredient prepared according to example 1 was used for the preparation of essential oil (pearl shiny and shiny essential oil) prepared from the following components in mass percent in table 3.
TABLE 3 essential oil composition Cheng Fenbiao
The preparation method comprises the following steps:
Adding the component A into a vacuum emulsifying pot, starting stirring, heating to 80 ℃, and preserving heat and stirring until the component A is uniformly dispersed;
When the temperature is reduced to 50 ℃, adding the component B and the component C preheated in advance at 50 ℃ and uniformly stirring;
And (3) when the temperature is reduced to 40 ℃, adding the component D, stirring uniformly, and reducing the temperature to room temperature.
The obtained essential oil is in a clear and transparent state.
Comparative example 2
An oil-soluble pearl B of an artificial cell membrane-entrapped pearl active ingredient prepared according to example 1 was used for the preparation of essential oil, which replaced coco-caprylate/caprate in Table 3 with the same mass percent of polar oil isononyl isononanoate, and the resulting essential oil was in a cloudy opaque state (as shown in FIG. 4).
From this, it can be derived that: the pearl active ingredient encapsulated by the artificial cell membrane can be prepared into clear and transparent essential oil only by being matched with the specific type of grease provided by the application.
Test example 1
Product stability test
The essential oils prepared as in example 2 were subjected to heat, cold, alternating and light stability tests, wherein:
the heat resistance test conditions were: 45+/-1 ℃, keeping constant temperature and avoiding light for 30 days;
The cold resistance test conditions are as follows: -20+/-1 ℃, keeping the temperature away from light and keeping the temperature away from light for 30 days;
the alternating test conditions were: transferring from-20deg.C constant temperature for 3.5 days to 45deg.C constant temperature for 3.5 days, and keeping away from light;
The illumination test conditions are as follows: illumination constant temperature and humidity test box (1.47×10 6 Lux·hr), 7d.
Compared with the essential oil prepared in the example 2 under normal temperature conditions, the product has no obvious change in smell, no precipitation in cold resistance and slightly deepened heat resistance and illumination color, and shows that the product has good stability.
Test example 2
Product safety test
The essential oil prepared as in example 2 was subjected to a number of (acute) skin irritation tests in guinea pigs, and applied continuously for 7 days, under the following test conditions: relative humidity of 20-24 ℃): 60-70%.
The results showed that the number of erythema was 0, the number of oedema was 0, the integral of the stimulus response was 0, and the stimulus intensity was graded as: no stimulating reaction.
Test example 3
Testing the product: the essential oil (the eushi diffuse pearl shiny brightening essential oil) prepared in example 2 was used by volunteers at the calf test area in the morning and evening for 28 days during the test. Each dose was 1 pump (about 0.3 g).
The testing method comprises the following steps: the enrolled volunteers visit before use (D0) and at 28 days of use (D28), wipe their lower legs with dry facial tissues after visit, and sit still in the test environment for at least 20 minutes during which they were unable to drink hot water and beverages, respectively. The volunteer satisfaction questionnaire was filled out at 28 days of visit. Number of test persons: 35 persons. Test area: the test area was randomly calibrated outside the volunteer's calf, with an area of 45cm 2 (circular area with a diameter of 7.6 cm). Test environment: the temperature (21+/-1) DEG C and the relative humidity (50+/-10)%, and carrying out real-time dynamic monitoring.
Volunteer satisfaction questionnaire analysis: the questionnaire is prepared from 1-9 minutes, 1 minute-very objectionable, 9 minutes-very agreeable. An effective number of people with a score > 5 and a satisfaction of greater than 50% may support relevant claims. The satisfaction degree calculating method comprises the following steps:
Satisfaction = number of subjects scored greater than 5 points/total number of effective persons x 100%;
and (3) calculating whether the probability of occurrence of TOP4 (score > 5 points) and BOT5 (score less than or equal to 5 points) is significantly different from the specified test proportion by adopting a binomial test, wherein the test proportion is 0.50.
Satisfaction results show that: 88.57% of volunteers agree that the product has moisturizing effect, and the skin is more moist after use; 88.57% of volunteers agree that "skin is finer after use"; 85.71% of volunteers agree "smoother skin after use"; 85.71% of volunteers agree "skin is tender after use"; 85.71% of volunteers agree "skin state is more stable after use"; 82.85% of volunteers agree "skin is shinier after use"; 71.42% of volunteers agree "skin is more resistant after use". The product has the effects of moisturizing and brightening.
In conclusion, the pearl active ingredient oil solution provided by the application is clear and transparent, has good safety and no toxicity or irritation, and can be applied to full-oil cosmetics. The skin external preparation, especially the full transparent essential oil, can make the corresponding skin external preparation have higher skin absorption and utilization rate, has luster after being used, can achieve good brightening effect, can improve the skin state after being used, and has no adverse reaction. The preparation process of the pearl active ingredient oil solution is simple, the operation is convenient, and the method is suitable for industrial production.
The above is only a preferred embodiment of the present invention, and is not intended to limit the present invention, but various modifications and variations can be made to the present invention by those skilled in the art. Any modification, equivalent replacement, improvement, etc. made within the spirit and principle of the present invention should be included in the protection scope of the present invention.
Claims (5)
1. The transparent clear essential oil is characterized by comprising, by mass, 0.01-10% of skin protectant, 0.1-2% of oil-soluble antioxidant, 0.1-10% of pearl active ingredient oil solution and the balance of medium-low polarity grease;
the preparation raw materials of the pearl active ingredient oil solution comprise the following components in percentage by weight: 0.9-1.1% of artificial cell membrane, 39-58% of octyl dodecanol isostearate, 4-12% of caprylic/capric triglyceride and 0.9-1.1% of pearl active ingredient, and the balance of caprylic/capric glyceride;
The physical and chemical parameters of the pearl active ingredient comprise: the water content is 0.1-7wt% and the calcium content is 10-17wt%; and the pH value of the pearl active ingredient solution obtained by dissolving the pearl active ingredient and water according to the weight ratio of 1:9 is 5.5-7.0;
the pearl active ingredient oil solution is in a clear and transparent state;
The medium-low polarity grease comprises at least one of cocoyl alcohol-caprylate/caprate, propyl heptyl caprylate, phytosterol/octyl dodecanol lauroyl glutamate, caprylic acid/capric glyceride, triolein, white pool flower seed oil, squalane, grape seed oil, camellia seed oil and sunflower seed oil;
The pearl active ingredient comprises at least one of water-soluble pearl powder, hydrolyzed pearl lyophilized powder, hydrolyzed conchiolin and pearl young factor; the artificial cell membrane is polyquaternium-51; the oil-soluble antioxidant is tocopheryl acetate.
2. The transparent clear essential oil according to claim 1, wherein the raw material for preparing the pearl active ingredient oil solution further comprises 0.5-1% of an antioxidant; the antioxidant is an oil-soluble antioxidant; the oil-soluble antioxidant is tocopheryl acetate.
3. A method for preparing the oil solution of pearl active ingredient according to claim 1 or 2, comprising the steps of: mixing the preparation raw materials according to the proportion.
4. A method of preparing according to claim 3, characterized in that the preparation comprises: mixing said artificial cell membrane, said pearl active ingredient and said octyldodecanol isostearate to obtain a first component;
Mixing the caprylic/capric glycerides, the caprylic/capric triglycerides, and the first component.
5. The method according to claim 4, wherein when an antioxidant is contained in the raw material for production, the mixture of caprylic/capric glycerides, caprylic/capric triglycerides, and the first component is mixed with the antioxidant.
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Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20100103173A (en) * | 2009-03-13 | 2010-09-27 | (주)아모레퍼시픽 | Hair cosmetic composition |
| CN101982164A (en) * | 2010-10-26 | 2011-03-02 | 浙江长生鸟珍珠生物科技有限公司 | Modified pearl cherry vitamin C sleeping mask and preparation method thereof |
| CN106265433A (en) * | 2016-08-24 | 2017-01-04 | 刘艺鹏 | Margarita Fructus Pruni pseudocerasi sleep mask |
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Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20100103173A (en) * | 2009-03-13 | 2010-09-27 | (주)아모레퍼시픽 | Hair cosmetic composition |
| CN101982164A (en) * | 2010-10-26 | 2011-03-02 | 浙江长生鸟珍珠生物科技有限公司 | Modified pearl cherry vitamin C sleeping mask and preparation method thereof |
| CN106265433A (en) * | 2016-08-24 | 2017-01-04 | 刘艺鹏 | Margarita Fructus Pruni pseudocerasi sleep mask |
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