CN116368137A - 用于治疗隐孢子虫病的化合物和组合物 - Google Patents

用于治疗隐孢子虫病的化合物和组合物 Download PDF

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Publication number
CN116368137A
CN116368137A CN202180069247.7A CN202180069247A CN116368137A CN 116368137 A CN116368137 A CN 116368137A CN 202180069247 A CN202180069247 A CN 202180069247A CN 116368137 A CN116368137 A CN 116368137A
Authority
CN
China
Prior art keywords
methyl
pyridine
carboxamido
compound
carbamoylphenyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN202180069247.7A
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English (en)
Chinese (zh)
Inventor
J·M·杨
M·R·特纳
卢佩超
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novartis AG
Original Assignee
Novartis AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis AG filed Critical Novartis AG
Publication of CN116368137A publication Critical patent/CN116368137A/zh
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pyridine Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
CN202180069247.7A 2020-10-14 2021-10-12 用于治疗隐孢子虫病的化合物和组合物 Pending CN116368137A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202063091866P 2020-10-14 2020-10-14
US63/091,866 2020-10-14
PCT/IB2021/059376 WO2022079616A1 (en) 2020-10-14 2021-10-12 Compounds and compositions for the treatment of cryptosporidiosis

Publications (1)

Publication Number Publication Date
CN116368137A true CN116368137A (zh) 2023-06-30

Family

ID=78302850

Family Applications (1)

Application Number Title Priority Date Filing Date
CN202180069247.7A Pending CN116368137A (zh) 2020-10-14 2021-10-12 用于治疗隐孢子虫病的化合物和组合物

Country Status (12)

Country Link
US (1) US12018024B2 (https=)
EP (1) EP4229055B1 (https=)
JP (1) JP7791184B2 (https=)
CN (1) CN116368137A (https=)
AR (1) AR123766A1 (https=)
AU (1) AU2021362803A1 (https=)
CA (1) CA3197199A1 (https=)
MX (1) MX2023004435A (https=)
PY (1) PY2189412A (https=)
TW (1) TW202229277A (https=)
UY (1) UY39466A (https=)
WO (1) WO2022079616A1 (https=)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR132352A1 (es) * 2023-04-13 2025-06-18 Syngenta Crop Protection Ag Derivados de imidazo[1,2-a]pirazina

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108495853A (zh) * 2016-01-21 2018-09-04 诺华股份有限公司 用于治疗隐孢子虫病的化合物和组合物

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
LT2925757T (lt) 2012-11-19 2017-12-27 Novartis Ag Junginiai ir kompozicijos, skirti parazitinių ligų gydymui
GB201700692D0 (en) 2017-01-16 2017-03-01 Salvensis Novel compounds and their use in the treatment of schistosomiasis

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108495853A (zh) * 2016-01-21 2018-09-04 诺华股份有限公司 用于治疗隐孢子虫病的化合物和组合物

Also Published As

Publication number Publication date
AR123766A1 (es) 2023-01-11
MX2023004435A (es) 2023-05-08
UY39466A (es) 2022-05-31
TW202229277A (zh) 2022-08-01
WO2022079616A1 (en) 2022-04-21
US20220112189A1 (en) 2022-04-14
PY2189412A (es) 2022-05-17
US12018024B2 (en) 2024-06-25
CA3197199A1 (en) 2022-04-21
JP2023545452A (ja) 2023-10-30
EP4229055A1 (en) 2023-08-23
EP4229055B1 (en) 2026-03-04
JP7791184B2 (ja) 2025-12-23
AU2021362803A1 (en) 2023-06-01

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