CN116348132A - 基于合成的被修饰的痘苗安卡拉(smva)的冠状病毒疫苗 - Google Patents
基于合成的被修饰的痘苗安卡拉(smva)的冠状病毒疫苗 Download PDFInfo
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- CN116348132A CN116348132A CN202180059838.6A CN202180059838A CN116348132A CN 116348132 A CN116348132 A CN 116348132A CN 202180059838 A CN202180059838 A CN 202180059838A CN 116348132 A CN116348132 A CN 116348132A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
- A61K39/215—Coronaviridae, e.g. avian infectious bronchitis virus
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
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- C—CHEMISTRY; METALLURGY
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- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
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- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
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- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/86—Viral vectors
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/53—DNA (RNA) vaccination
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/545—Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/57—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2
- A61K2039/572—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2 cytotoxic response
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/57—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2
- A61K2039/575—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2 humoral response
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/03—Fusion polypeptide containing a localisation/targetting motif containing a transmembrane segment
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/24011—Poxviridae
- C12N2710/24111—Orthopoxvirus, e.g. vaccinia virus, variola
- C12N2710/24141—Use of virus, viral particle or viral elements as a vector
- C12N2710/24143—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/24011—Poxviridae
- C12N2710/24111—Orthopoxvirus, e.g. vaccinia virus, variola
- C12N2710/24171—Demonstrated in vivo effect
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
- C12N2770/00011—Details
- C12N2770/20011—Coronaviridae
- C12N2770/20022—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
- C12N2770/00011—Details
- C12N2770/20011—Coronaviridae
- C12N2770/20034—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
- C12N2770/00011—Details
- C12N2770/20011—Coronaviridae
- C12N2770/20071—Demonstrated in vivo effect
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Genetics & Genomics (AREA)
- Organic Chemistry (AREA)
- Virology (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Medicinal Chemistry (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Biotechnology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Microbiology (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Plant Pathology (AREA)
- Physics & Mathematics (AREA)
- Communicable Diseases (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Mycology (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pulmonology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Peptides Or Proteins (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (9)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202063026127P | 2020-05-17 | 2020-05-17 | |
| US63/026,127 | 2020-05-17 | ||
| US202063044033P | 2020-06-25 | 2020-06-25 | |
| US63/044,033 | 2020-06-25 | ||
| US202063113810P | 2020-11-13 | 2020-11-13 | |
| US63/113,810 | 2020-11-13 | ||
| US202163161371P | 2021-03-15 | 2021-03-15 | |
| US63/161,371 | 2021-03-15 | ||
| PCT/US2021/032821 WO2021236550A1 (en) | 2020-05-17 | 2021-05-17 | Synthetic modified vaccinia ankara (smva) based coronavirus vaccines |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN116348132A true CN116348132A (zh) | 2023-06-27 |
Family
ID=78708032
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202180059838.6A Pending CN116348132A (zh) | 2020-05-17 | 2021-05-17 | 基于合成的被修饰的痘苗安卡拉(smva)的冠状病毒疫苗 |
Country Status (11)
| Country | Link |
|---|---|
| US (2) | US20230323389A1 (enExample) |
| EP (1) | EP4153228A4 (enExample) |
| JP (2) | JP7788403B2 (enExample) |
| KR (1) | KR20230012583A (enExample) |
| CN (1) | CN116348132A (enExample) |
| AU (1) | AU2021276265A1 (enExample) |
| BR (1) | BR112022023173A2 (enExample) |
| CA (1) | CA3183016A1 (enExample) |
| IL (1) | IL298210A (enExample) |
| MX (1) | MX2022014387A (enExample) |
| WO (1) | WO2021236550A1 (enExample) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA3167052A1 (en) | 2020-02-14 | 2021-08-19 | Mary Jo Hauser | Vaccines and uses thereof to induce an immune response to sars-cov2 |
| EP4153228A4 (en) | 2020-05-17 | 2024-07-10 | City of Hope | CORONAVIRUS VACCINES BASED ON SYNTHETIC MODIFIED ANKARA VACCINE (SMVA) VIRUS |
| TW202330575A (zh) * | 2021-09-29 | 2023-08-01 | 瑞典商斯文斯卡疫苗生產股份有限公司 | 用於治療及預防冠狀病毒之組成物及方法 |
| US20250235527A1 (en) * | 2021-11-17 | 2025-07-24 | City Of Hope | Synthetic modified vaccinia ankara (smva) based coronavirus vaccines |
| CN117384864A (zh) * | 2022-07-11 | 2024-01-12 | 清华大学 | 表达SARS-CoV-2 Omicron Spike蛋白的重组腺病毒及其应用 |
| EP4558171A1 (en) * | 2022-07-22 | 2025-05-28 | City of Hope | Synthetic modified vaccinia ankara vaccines to stimulate orthopox and monkeypox virus immunity |
| EP4316514A1 (en) * | 2022-08-03 | 2024-02-07 | Consejo Superior de Investigaciones Científicas (CSIC) | Mva-based vectors and their use as vaccine against sars-cov-2 |
| TW202426045A (zh) * | 2022-10-07 | 2024-07-01 | 高端疫苗生物製劑股份有限公司 | 抗新型冠狀病毒(SARS-CoV-2) Omicron變異株之免疫組合物 |
| WO2026030724A1 (en) * | 2024-08-01 | 2026-02-05 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Sars-cov-2 vaccine |
| WO2026087525A1 (en) | 2024-10-21 | 2026-04-30 | Julius-Maximilians-Universität Würzburg, In Vertretung Des Freistaates Bayern | A deliverable cytosolic gene expression system based on poxviral rna polymerase and dna templates |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2006071250A2 (en) * | 2004-04-05 | 2006-07-06 | Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Soluble fragments of the sars-cov spike glycoprotein |
| WO2016116398A1 (en) * | 2015-01-19 | 2016-07-28 | Ludwig-Maximilians-Universität München | A novel vaccine against the middle east respiratory syndrome coronavirus (mers-cov) |
Family Cites Families (26)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CA2431349A1 (en) | 2002-06-06 | 2003-12-06 | Xiao-Dan Yao | Method of producing a recombinant virus |
| JP5052893B2 (ja) | 2003-02-20 | 2012-10-17 | アメリカ合衆国 | ポックスベクターにおける新規の挿入部位 |
| WO2005016238A2 (en) * | 2003-05-08 | 2005-02-24 | Duke University | Severe acute respiratory syndrome |
| EP1678292A4 (en) * | 2003-09-18 | 2008-05-07 | Univ Emory | IMPROVED MVA VACCINES |
| DK2402451T3 (en) | 2006-08-25 | 2018-06-25 | The Government Of The Us Secretary Department Of Health And Human Services | Method for Stabilizing a DNA Insert in a Recombinant Vaccine Vector |
| WO2011047324A1 (en) | 2009-10-16 | 2011-04-21 | The U.S.A. As Represented By The Secretary , Department Of Health And Human Services . | Recombinant modified vaccinia ankara (mva) vaccinia virus containing restructured insertion sites |
| US20210260181A1 (en) * | 2014-09-16 | 2021-08-26 | Altimmune, Inc | Coronavirus immunogenic compositions and uses thereof |
| AU2017272721B2 (en) | 2016-05-30 | 2023-03-30 | Astellas Pharma Inc. | Novel genetically engineered vaccinia viruses |
| IL319942A (en) | 2016-11-02 | 2025-05-01 | Evans David | Synthetic chimeric poxviruses, methods for their production, compositions containing them and uses thereof |
| KR20240113607A (ko) | 2017-06-21 | 2024-07-22 | 트랜스진 | 개인 맞춤형 백신 |
| WO2019014569A1 (en) * | 2017-07-13 | 2019-01-17 | City Of Hope | EXPRESSION SYSTEM FOR EXPRESSING GLYCOPROTEIN COMPLEXES OF HERPESVIRUS |
| CA3099330A1 (en) * | 2018-05-02 | 2019-11-07 | Tonix Pharma Holdings Limited | Synthetic chimeric vaccinia virus |
| TW202204380A (zh) | 2020-01-31 | 2022-02-01 | 美商詹森藥物公司 | 用於預防及治療冠狀病毒感染之組合物及方法-sars-cov-2疫苗 |
| CN115397998A (zh) | 2020-02-03 | 2022-11-25 | 希望之城 | 由天然或合成dna产生的基于痘病毒的载体及其用途 |
| DE202021004130U1 (de) | 2020-02-04 | 2022-10-26 | Curevac Ag | Coronavirus-Vakzine |
| BR112022016054A2 (pt) * | 2020-02-14 | 2022-10-11 | Altimmune Inc | Composições imunogênicas para coronavírus e usos das mesmas |
| CA3167052A1 (en) | 2020-02-14 | 2021-08-19 | Mary Jo Hauser | Vaccines and uses thereof to induce an immune response to sars-cov2 |
| GB2594683A (en) | 2020-02-17 | 2021-11-10 | Vaxbio Ltd | Vaccine |
| BR112022016992A2 (pt) * | 2020-02-26 | 2022-10-25 | Tonix Pharma Ltd | Vacina com base em poxvírus recombinante contra ví-rus sars-cov-2 |
| WO2021178416A1 (en) * | 2020-03-02 | 2021-09-10 | Heat Biologics, Inc. | Immune-mediated coronavirus treatments |
| US11202753B1 (en) * | 2020-03-06 | 2021-12-21 | Aquavit Pharmaceuticals, Inc. | Systems and methods for generating immune responses in subjects using microchannel delivery devices |
| KR20220152248A (ko) | 2020-03-13 | 2022-11-15 | 옥스포드 유니버시티 이노베이션 리미티드 | 면역 반응을 유도하기 위한 조성물 및 방법 |
| TW202203966A (zh) | 2020-03-31 | 2022-02-01 | 澳大利亞商賽門蒂斯公司 | 用於防範covid-19之以減毒的痘病毒載體為底質之疫苗 |
| WO2021216743A2 (en) | 2020-04-21 | 2021-10-28 | Emory University | Coronavirus vaccines, compositions, and methods related thereto |
| EP4153228A4 (en) | 2020-05-17 | 2024-07-10 | City of Hope | CORONAVIRUS VACCINES BASED ON SYNTHETIC MODIFIED ANKARA VACCINE (SMVA) VIRUS |
| US20220370600A1 (en) * | 2021-05-21 | 2022-11-24 | Board Of Regents, The University Of Texas System | Multigenic mva-sars-cov-2 vaccine |
-
2021
- 2021-05-17 EP EP21809653.5A patent/EP4153228A4/en active Pending
- 2021-05-17 BR BR112022023173A patent/BR112022023173A2/pt unknown
- 2021-05-17 AU AU2021276265A patent/AU2021276265A1/en active Pending
- 2021-05-17 MX MX2022014387A patent/MX2022014387A/es unknown
- 2021-05-17 IL IL298210A patent/IL298210A/en unknown
- 2021-05-17 CN CN202180059838.6A patent/CN116348132A/zh active Pending
- 2021-05-17 KR KR1020227044240A patent/KR20230012583A/ko active Pending
- 2021-05-17 JP JP2022570108A patent/JP7788403B2/ja active Active
- 2021-05-17 CA CA3183016A patent/CA3183016A1/en active Pending
- 2021-05-17 WO PCT/US2021/032821 patent/WO2021236550A1/en not_active Ceased
- 2021-05-17 US US17/999,170 patent/US20230323389A1/en active Pending
-
2025
- 2025-04-18 US US19/183,257 patent/US12584146B2/en active Active
- 2025-12-08 JP JP2025238238A patent/JP2026041921A/ja active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2006071250A2 (en) * | 2004-04-05 | 2006-07-06 | Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Soluble fragments of the sars-cov spike glycoprotein |
| WO2016116398A1 (en) * | 2015-01-19 | 2016-07-28 | Ludwig-Maximilians-Universität München | A novel vaccine against the middle east respiratory syndrome coronavirus (mers-cov) |
Non-Patent Citations (4)
| Title |
|---|
| FLAVIA CHIUPPESI等: "Development of a multi-antigenic SARS-CoV-2 vaccine candidate using a synthetic poxvirus platform", NATURE COMMUNICATION, vol. 11, 31 December 2020 (2020-12-31), pages 6121 * |
| MARKUS CZUB等: "Evaluation of modified vaccinia virus Ankara based recombinant SARS vaccine in ferrets", VACCINE, vol. 23, 23 January 2005 (2005-01-23), pages 2273 - 2279 * |
| WEILONG SHANG等: "The outbreak of SARS-CoV-2 pneumonia calls for viral vaccines", NPJ VACCINE, vol. 5, 6 March 2020 (2020-03-06), pages 1 * |
| ZHIWEI CHEN等: "Recombinant Modified Vaccinia Virus Ankara Expressing the Spike Glycoprotein of Severe Acute Respiratory Syndrome Coronavirus Induces Protective Neutralizing Antibodies Primarily Targeting the Receptor Binding Region", JOURNAL OF VIROLOGY, vol. 79, no. 5, 31 March 2005 (2005-03-31), pages 2678 - 2688 * |
Also Published As
| Publication number | Publication date |
|---|---|
| JP2026041921A (ja) | 2026-03-10 |
| BR112022023173A2 (pt) | 2022-12-27 |
| WO2021236550A1 (en) | 2021-11-25 |
| CA3183016A1 (en) | 2021-11-25 |
| JP7788403B2 (ja) | 2025-12-18 |
| US12584146B2 (en) | 2026-03-24 |
| EP4153228A1 (en) | 2023-03-29 |
| MX2022014387A (es) | 2023-04-11 |
| JP2023526073A (ja) | 2023-06-20 |
| US20250313858A1 (en) | 2025-10-09 |
| KR20230012583A (ko) | 2023-01-26 |
| AU2021276265A1 (en) | 2022-12-08 |
| US20230323389A1 (en) | 2023-10-12 |
| IL298210A (en) | 2023-01-01 |
| EP4153228A4 (en) | 2024-07-10 |
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