CN116338218A - Sample analyzer and control method for sample analyzer - Google Patents
Sample analyzer and control method for sample analyzer Download PDFInfo
- Publication number
- CN116338218A CN116338218A CN202211394501.3A CN202211394501A CN116338218A CN 116338218 A CN116338218 A CN 116338218A CN 202211394501 A CN202211394501 A CN 202211394501A CN 116338218 A CN116338218 A CN 116338218A
- Authority
- CN
- China
- Prior art keywords
- module
- gas
- supplementing
- control valve
- mixing tank
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 238000000034 method Methods 0.000 title claims abstract description 51
- 239000007788 liquid Substances 0.000 claims abstract description 223
- 230000001502 supplementing effect Effects 0.000 claims abstract description 205
- 238000004140 cleaning Methods 0.000 claims abstract description 155
- 239000000203 mixture Substances 0.000 claims abstract description 106
- 239000003153 chemical reaction reagent Substances 0.000 claims abstract description 70
- 238000001514 detection method Methods 0.000 claims abstract description 27
- 239000002699 waste material Substances 0.000 claims description 14
- 238000002360 preparation method Methods 0.000 claims description 9
- 230000010355 oscillation Effects 0.000 claims description 8
- 238000007599 discharging Methods 0.000 claims description 4
- 239000004973 liquid crystal related substance Substances 0.000 claims 2
- 239000007789 gas Substances 0.000 description 141
- 230000000153 supplemental effect Effects 0.000 description 10
- 239000012530 fluid Substances 0.000 description 6
- 239000004816 latex Substances 0.000 description 6
- 229920000126 latex Polymers 0.000 description 6
- 238000005070 sampling Methods 0.000 description 6
- 230000015572 biosynthetic process Effects 0.000 description 5
- 102000004169 proteins and genes Human genes 0.000 description 5
- 108090000623 proteins and genes Proteins 0.000 description 5
- 102100032752 C-reactive protein Human genes 0.000 description 3
- 239000012071 phase Substances 0.000 description 3
- 238000005406 washing Methods 0.000 description 3
- 108010074051 C-Reactive Protein Proteins 0.000 description 2
- 230000001174 ascending effect Effects 0.000 description 2
- 239000008280 blood Substances 0.000 description 2
- 210000004369 blood Anatomy 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 108700028909 Serum Amyloid A Proteins 0.000 description 1
- 102000054727 Serum Amyloid A Human genes 0.000 description 1
- 239000000853 adhesive Substances 0.000 description 1
- 230000001070 adhesive effect Effects 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000005587 bubbling Effects 0.000 description 1
- 239000006185 dispersion Substances 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 239000000284 extract Substances 0.000 description 1
- 239000007791 liquid phase Substances 0.000 description 1
- 230000001737 promoting effect Effects 0.000 description 1
- 230000005514 two-phase flow Effects 0.000 description 1
Images
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F23/00—Mixing according to the phases to be mixed, e.g. dispersing or emulsifying
- B01F23/20—Mixing gases with liquids
- B01F23/23—Mixing gases with liquids by introducing gases into liquid media, e.g. for producing aerated liquids
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F33/00—Other mixers; Mixing plants; Combinations of mixers
- B01F33/40—Mixers using gas or liquid agitation, e.g. with air supply tubes
- B01F33/403—Mixers using gas or liquid agitation, e.g. with air supply tubes for mixing liquids
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F2101/00—Mixing characterised by the nature of the mixed materials or by the application field
- B01F2101/23—Mixing of laboratory samples e.g. in preparation of analysing or testing properties of materials
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N2035/00465—Separating and mixing arrangements
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/46—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans from vertebrates
- G01N2333/47—Assays involving proteins of known structure or function as defined in the subgroups
- G01N2333/4701—Details
- G01N2333/4709—Amyloid plaque core protein
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/46—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans from vertebrates
- G01N2333/47—Assays involving proteins of known structure or function as defined in the subgroups
- G01N2333/4701—Details
- G01N2333/4737—C-reactive protein
Abstract
The application discloses a sample analyzer and a control method of the sample analyzer, and relates to the technical field of medical detection. The sample analyzer comprises a sample supplementing module, a reagent supplementing module, a mixing pool, a gas supplementing module, a cleaning solution supplementing module and a module to be cleaned; when the sample analyzer is in a sample detection working mode, the mixing pool is used for receiving sample liquid provided by the sample supplementing module, reagent provided by the reagent supplementing module and gas provided by the gas supplementing module, so that the gas received by the mixing pool mixes the sample liquid and the reagent received by the mixing pool uniformly to form a sample; when the sample analyzer is in a cleaning working mode, the mixing tank is used for receiving the cleaning solution provided by the cleaning solution supplementing module and the gas provided by the gas supplementing module, so that the cleaning solution and the gas received by the mixing tank are mixed to form a gas-liquid mixture, and the module to be cleaned is cleaned through the gas-liquid mixture. The application can effectively clean the reagent attached in the module to be cleaned.
Description
Technical Field
The present application relates to the field of medical detection technology, and in particular, to a sample analyzer and a control method for the sample analyzer.
Background
The sample analyzer needs to use a reagent in the detection process, and because the reagent can adhere to the pipe wall of the liquid path system, the liquid path system needs to be cleaned by cleaning liquid to remove the reagent adhered to the pipe wall.
A common cleaning method for the liquid path system of the sample analyzer is to directly rinse the liquid path system by a cleaning liquid, which is difficult to effectively clean the liquid path system.
Disclosure of Invention
In view of the above, the present application provides a sample analyzer and a control method of the sample analyzer.
In order to achieve the above object, the present application provides a sample analyzer having a sample detection operation mode and a cleaning operation mode, the sample analyzer including a sample replenishing module, a reagent replenishing module, a mixing tank, a gas replenishing module, a cleaning liquid replenishing module, and a module to be cleaned;
when the sample analyzer is in the sample detection working mode, the mixing tank is used for receiving the sample liquid provided by the sample supplementing module, the reagent provided by the reagent supplementing module and the gas provided by the gas supplementing module, so that the gas received by the mixing tank mixes the sample liquid and the reagent received by the mixing tank uniformly to form a sample;
When the sample analyzer is in the cleaning working mode, the mixing tank is used for receiving the cleaning solution provided by the cleaning solution supplementing module and the gas provided by the gas supplementing module, so that the cleaning solution and the gas received by the mixing tank are mixed to form a gas-liquid mixture, the module to be cleaned is further cleaned through the gas-liquid mixture,
the to-be-cleaned module is provided with a waste liquid discharge port, and the sample analyzer comprises a first control valve which is connected in series with the waste liquid discharge port; the first control valve is used for discharging the gas-liquid mixture in the module to be cleaned through the waste liquid discharge port after the gas-liquid mixture cleans the module to be cleaned,
the sample analyzer comprises a negative pressure driving component which is connected with the waste liquid discharge port and the first control valve in series and is used for driving the gas-liquid mixture to be discharged through the opened first control valve after the gas-liquid mixture is washed out of the module to be washed,
the negative pressure driving part drives the gas-liquid mixture in the module to be cleaned to be discharged through the opened first control valve after the gas-liquid mixture cleans the module to be cleaned, wherein the discharging speed of the gas-liquid mixture in the module to be cleaned is larger than the speed of the mixing tank for guiding the gas-liquid mixture to the module to be cleaned before the gas-liquid mixture cleans the module to be cleaned.
In order to solve the technical problem, another technical scheme adopted by the application is to provide a control method of a sample analyzer, which is applied to the sample analyzer, wherein the sample analyzer comprises a fourth control valve, a fifth control valve and a sixth control valve, the fourth control valve is connected in series between the sample supplementing module and the mixing tank, the fifth control valve is connected in series between the reagent supplementing module and the mixing tank, the sixth control valve is connected in series between the gas supplementing module and the mixing tank, and the sample analyzer is provided with a sample detection working mode and a cleaning working mode in advance; the control method comprises the following steps:
switching to a corresponding one of the sample detection working mode and the cleaning working mode according to a working mode setting instruction;
when switching to the sample detection operation mode, performing a sample preparation step, the sample preparation step comprising: receiving the sample liquid provided by the sample supplementing module and the reagent provided by the reagent supplementing module through a mixing pool;
closing the fourth control valve and the fifth control valve, intermittently opening the sixth control valve, and receiving gas intermittently provided by the gas supplementing module at one or more preset interval time intervals based on a first gas supplementing parameter through the mixing tank so as to mix the sample liquid and the reagent received by the mixing tank uniformly to form the sample; the first air supplementing parameter comprises time of supplementing air each time, time interval of two adjacent supplementing air and driving air pressure of supplementing air each time.
In order to solve the above technical problem, another technical solution adopted in the present application is to provide a cleaning method of a sample analyzer, which is applied to the above sample analyzer, where the sample analyzer includes a third control valve and a sixth control valve, the third control valve is connected in series between the mixing tank and the module to be cleaned, and the sixth control valve is connected in series between the gas supplementing module and the mixing tank, and the method includes:
the cleaning solution provided by the cleaning solution supplementing module and the gas provided by the gas supplementing module are received through the mixing tank, so that the cleaning solution and the gas received by the mixing tank are mixed to form a gas-liquid mixture; opening the third control valve, closing the sixth control valve, and providing the gas-liquid mixture to the module to be cleaned through the mixing pool;
and closing the third control valve, and cleaning the module to be cleaned again through the gas-liquid mixture in the module to be cleaned.
In order to solve the technical problem, another technical scheme adopted by the application is to provide a cleaning method of a sample analyzer, which is applied to the sample analyzer, wherein the sample analyzer comprises a third control valve, a sixth control valve and a seventh control valve, the third control valve is connected in series between the mixing tank and the module to be cleaned, the sixth control valve is connected in series between the gas supplementing module and the mixing tank, and the seventh control valve is connected in series between the cleaning solution supplementing module and the module to be cleaned; the to-be-cleaned module is respectively connected with the cleaning solution supplementing module and the mixing tank, the mixing tank is provided with a liquid outlet interface and a gas supplementing interface, and the height of the gas supplementing interface from the bottom of the mixing tank is smaller than the height of the top of the mixing tank from the bottom of the mixing tank; the gas supplementing module is connected with the gas supplementing interface, and the module to be cleaned is connected with the liquid outlet interface;
The method comprises the following steps:
opening the seventh control valve, closing the third control valve, and providing cleaning liquid to the module to be cleaned through the cleaning liquid supplementing module;
closing the seventh control valve to perform primary cleaning on the module to be cleaned through cleaning liquid in the module to be cleaned;
the third control valve is opened, and the cleaning liquid in the module to be cleaned is received through the mixing tank, so that the liquid level in the mixing tank is lifted to be higher than the air supplementing interface;
closing the third control valve, intermittently opening the sixth control valve, and receiving the gas intermittently provided by the gas supplementing module at one or more preset time intervals based on a second gas supplementing parameter through the mixing tank so as to mix with the cleaning solution received by the mixing tank, thereby forming the gas-liquid mixture; the second air supplementing parameters comprise time for supplementing air each time, time interval between two adjacent air supplementing times and driving air pressure of the air supplementing each time, and are different from the first air supplementing parameters, wherein the first air supplementing parameters are parameters that the air supplementing module intermittently provides air to the mixing pool at one or more preset interval time intervals;
And guiding the gas-liquid mixture to the module to be cleaned through the mixing pool so as to clean the module to be cleaned.
The beneficial effects are that: compared with the prior art, when the sample analyzer is in the sample detection working mode, the mixing tank mixes the received sample liquid and the reagent through the received gas to form a sample, and when the sample analyzer is in the cleaning working mode, the mixing tank mixes the received gas and the received cleaning liquid to form a gas-liquid mixture, so that the reagent attached to the module to be cleaned can be effectively cleaned by utilizing the cavitation of the gas-liquid mixture.
Drawings
FIG. 1 is a schematic view of a portion of a fluid circuit of one implementation of a sample analyzer embodiment of the present application;
FIG. 2 is a schematic view of a portion of a fluid circuit of another implementation of the sample analyzer embodiment of the present application;
FIG. 3 is a flow chart of a first embodiment of a control method of the sample analyzer of the present application;
FIG. 4 is a schematic flow chart of a sample preparation step in a first embodiment of a control method of the sample analyzer of the present application;
FIG. 5 is a schematic flow chart of a cleaning step in a first embodiment of a control method of the sample analyzer of the present application;
FIG. 6 is a flowchart of step S400 in a second embodiment of a control method of the sample analyzer of the present application;
FIG. 7 is a flowchart of step S410 in a third embodiment of a control method of the sample analyzer of the present application;
FIG. 8 is a flowchart of step S420 in a third embodiment of a control method of the sample analyzer of the present application;
FIG. 9 is a flowchart of step S410 in a fifth embodiment of a control method of the sample analyzer of the present application;
fig. 10 is a flowchart of step S420 in a fifth embodiment of a control method of the sample analyzer of the present application.
Reference numerals illustrate:
100. a sample analyzer; 110. a sample replenishment module; 120. a reagent replenishment module; 130. mixing well; 140. a gas replenishment module; 150. a cleaning solution replenishing module; 160. a module to be cleaned; 170. an oscillation module; 180. a negative pressure driving part;
101. a gas supplementing interface, a liquid outlet interface and a liquid outlet interface; 103. an exhaust port; 104. a waste liquid discharge port; 191. a first control valve; 192. a second control valve; 193. a third control valve; 194. a fourth control valve; 195. a fifth control valve; 196. a sixth control valve; 197. a seventh control valve; 198. and an eighth control valve.
Detailed Description
In order to better understand the technical solutions of the present application, the following describes the present application in further detail with reference to the drawings and the detailed description. It will be apparent that the described embodiments are only some, but not all, of the embodiments of the present application. All other embodiments, based on the embodiments herein, which would be apparent to one of ordinary skill in the art without undue burden are within the scope of the present application.
1-2, FIG. 1 is a schematic view of a portion of a fluid path of an embodiment of a sample analyzer of the present application; fig. 2 is a schematic view of a portion of a fluid circuit of another implementation of the sample analyzer embodiment of the present application.
As shown in fig. 1 to 2, the sample analyzer 100 has a sample detection operation mode and a washing operation mode, and the sample analyzer 100 includes a sample replenishment module 110, a reagent replenishment module 120, a mixing tank 130, a gas replenishment module 140, a cleaning liquid replenishment module 150, and a module to be washed 160.
When the sample analyzer 100 is in the sample detection operation mode, the mixing tank 130 is configured to receive the sample liquid provided by the sample supplementing module 110, the reagent provided by the reagent supplementing module 120, and the gas provided by the gas supplementing module 140, so that the gas received by the mixing tank 130 mixes the sample liquid and the reagent received by the mixing tank 130 to form a sample.
When the sample analyzer 100 is in the cleaning mode, the mixing tank 130 is configured to receive the cleaning solution provided by the cleaning solution replenishing module 150 and the gas provided by the gas replenishing module 140, so that the cleaning solution and the gas received by the mixing tank 130 are mixed to form a gas-liquid mixture, and the module 160 to be cleaned is cleaned by the gas-liquid mixture.
In this way, when the sample analyzer 100 is in the sample detection mode, the mixing tank 130 mixes the received sample liquid and the reagent with the received gas to form a sample, and when the sample analyzer 100 is in the cleaning mode, the mixing tank 130 mixes the received gas with the received cleaning liquid to form a gas-liquid mixture, so that the reagent attached to the module 160 to be cleaned can be effectively cleaned by cavitation of the gas-liquid mixture.
In an exemplary embodiment, the module to be cleaned 160 may be a specific protein analysis module requiring the use of latex reagents. Specific proteins for analysis by this specific protein analysis module include, but are not limited to, one or more of CRP (C-reactive protein, also known as C-reactive protein) and SAA (Serumamycin A, also known as serum amyloid A).
The inventor finds that the latex reagent has strong adhesive capability on the pipe wall, and the specific protein analysis module is directly washed by adopting the cleaning solution, so that the latex reagent adhered on the pipe wall of the specific protein analysis module is difficult to effectively wash.
In this application, when the gas-liquid mixture formed in the mixing tank 130 is led to the module 160 to be cleaned to clean the module 160 to be cleaned, a gas-liquid two-phase flow can be formed, and the latex reagent attached in the module 160 to be cleaned is alternately contacted with the gas phase and the liquid phase in the gas-liquid mixture, so that the attached latex reagent is subjected to the action force of fluctuation and change, and the attached latex reagent is convenient to fall off.
Further, the mixing tank 130 is provided with a liquid outlet port 102 and a gas supplementing port 101, and the height of the gas supplementing port 101 from the bottom of the mixing tank 130 is smaller than the height of the top of the mixing tank 130 from the bottom of the mixing tank 130; the gas supplementing module 140 is connected with the gas supplementing interface 101, and the module to be cleaned 160 is connected with the liquid outlet interface 102.
Wherein, the mixing tank 130 is used for receiving the cleaning solution provided by the cleaning solution supplementing module 150 to raise the liquid level in the mixing tank 130 to be higher than the air supplementing interface 101, and receiving the air provided by the air supplementing module 140, so that the cleaning solution received by the mixing tank 130 is mixed with the air to form a gas-liquid mixture; the mixing tank 130 is used for guiding the gas-liquid mixture to the module 160 to be cleaned so as to clean the module 160 to be cleaned.
In the above manner, since the air supplementing port 101 is located at a position between the bottom and the top of the mixing tank, after the liquid level in the mixing tank 130 is raised to be higher than the air supplementing port 101, the air supplied by the air supplementing module 140 and received by the mixing tank 130 can be conveniently dispersed in the cleaning solution in the mixing tank 130 through the air supplementing port 101 to form a gas-liquid mixture.
Further, as shown in fig. 1-2, the module to be cleaned 160 is provided with a waste liquid discharge port 104, and the sample analyzer 100 includes a first control valve 191, the first control valve 191 is connected in series with the waste liquid discharge port 104, and the first control valve 191 is configured to enable the gas-liquid mixture to be discharged through the waste liquid discharge port 104 after the gas-liquid mixture has been cleaned of the module to be cleaned 160.
Further, as shown in fig. 1-2, the sample analyzer 100 includes a negative pressure driving part 180, the negative pressure driving part 180 is connected in series with the waste liquid discharge port 104 and the first control valve 191, and the negative pressure driving part 180 is used for driving the gas-liquid mixture to be discharged through the opened first control valve 191 after the gas-liquid mixture has been washed out of the module 160 to be washed.
In one example, after cleaning the module 160 to be cleaned, the gas-liquid mixture in the module 160 to be cleaned is discharged through the opened first control valve 191 based on the suction of the negative pressure driving part 180.
In this embodiment, since the negative pressure driving component 180 extracts the gas-liquid mixture in the module 160 to be cleaned, the bubbles attached to the pipe wall in the module 160 to be cleaned in the gas-liquid mixture can be expanded, and the expanded bubbles are more likely to separate from the pipe wall in the module 160 to be cleaned and separate and take away the blood stain, the reagent and the like attached to the pipe wall in the module 160 to be cleaned.
Further, the negative pressure driving part 180 drives the gas-liquid mixture to be discharged through the opened first control valve 191 at a rate greater than that of the mixing tank 130 to guide the gas-liquid mixture to the module 160 before the gas-liquid mixture washes the module 160.
In this way, the gas-liquid mixture can be guided from the mixing pool 130 into the module 160 to be cleaned at a relatively gentle speed, so that overflow of bubbles in the gas-liquid mixture in the process can be avoided or reduced, part of the bubbles in the gas-liquid mixture can be stably attached to the pipe wall in the module 160 to be cleaned in the process of entering the module 160 to be cleaned, after the gas-liquid mixture enters the module 160 to be cleaned, the bubbles attached in the module 160 to be cleaned can be rapidly expanded based on rapid evacuation of the negative pressure driving part 180, cavitation is generated, and accordingly blood stains, reagents and the like in the area where the bubbles are attached are dissociated and taken away.
Thus, in one example, the negative pressure driving part 180 is used to drive the gas-liquid mixture in the module to be cleaned 160 to be discharged through the opened first control valve 191 using the highest driving gear after the gas-liquid mixture is cleaned.
Further, as shown in fig. 1-2, the sample analyzer 100 includes a third control valve 193, a fourth control valve 194, a fifth control valve 195, and a sixth control valve 196, wherein the third control valve 193 is connected in series between the mixing tank 130 and the module to be cleaned 160, the fourth control valve 194 is connected in series between the sample replenishment module 110 and the mixing tank 130, the fifth control valve 195 is connected in series between the reagent replenishment module 120 and the mixing tank 130, and the sixth control valve 196 is connected in series between the gas replenishment module 140 and the mixing tank 130.
In other examples (not shown), the sample analyzer includes a mixing module coupled to the mixing tank for mixing the sample fluid and the reagent received by the mixing tank to facilitate formation of the sample when the sample analyzer is in a sample detection mode of operation, and for mixing the cleaning fluid and the gas received by the mixing tank to facilitate formation of the gas-liquid mixture when the sample analyzer is in a cleaning mode of operation.
Further, the mixing module comprises an injector and/or a stirrer, wherein the injector is used for bubbling into the mixing tank when the sample analyzer is in a sample detection working mode so as to mix the sample liquid and the reagent received by the mixing tank uniformly, thereby promoting the formation of a sample; the stirrer is used for driving liquid in the mixing tank to shake when the sample analyzer is in a sample detection working mode so as to mix sample liquid and reagent received by the mixing tank uniformly and promote the formation of a sample, and is used for driving liquid in the mixing tank to shake when the sample analyzer is in a cleaning working mode so as to mix cleaning liquid and gas received by the mixing tank and promote the formation of a gas-liquid mixture.
3-5, FIG. 3 is a schematic flow chart of a first embodiment of a control method of the sample analyzer of the present application; FIG. 4 is a schematic flow chart of a sample preparation step in a first embodiment of a control method of the sample analyzer of the present application; fig. 5 is a schematic flow chart of a cleaning step in a first embodiment of a control method of the sample analyzer of the present application.
As shown in fig. 3, the control method of the sample analyzer includes steps S100 to S200.
Step S100: according to the working mode setting instruction, the working mode is switched to a corresponding one of the sample detection working mode and the cleaning working mode.
In one example, the sample analyzer may receive the operation mode setting instruction by receiving an operation instruction of a user.
In one example, the sample analyzer may also generate the operating mode setting instructions based on its own running program.
Thereby switching to a corresponding one of the sample detection operation mode and the cleaning operation mode according to the operation mode setting instruction.
Step S100: the sample preparation step is performed when switching to the sample detection mode of operation, and the washing step is performed when switching to the washing mode of operation of the sample analyzer.
In step S200, the sample analyzer performs different steps according to the different operation modes, and when the sample analyzer is switched to the sample detection operation mode, the sample preparation step is performed, and when the sample analyzer is switched to the cleaning operation mode, the cleaning step is performed.
As shown in fig. 4, the sample preparation step includes steps S310 to S320.
Step S310: the sample liquid provided by the sample supplementing module and the reagent provided by the reagent supplementing module are received through the mixing pool.
The mixing tank may receive the sample liquid provided by the sample replenishment module and the reagent provided by the reagent replenishment module simultaneously or sequentially in step S310.
Step S320: and the gas provided by the gas supplementing module is received through the mixing tank so as to uniformly mix the sample liquid and the reagent received by the mixing tank to form a sample.
In step S320, the mixing tank may intermittently receive the gas provided by the gas replenishment module or may continuously receive the gas provided by the gas replenishment module, so as to mix the sample liquid and the reagent received by the mixing tank to form a sample.
As shown in fig. 5, the cleaning step includes step S400.
Step S400: the cleaning solution provided by the cleaning solution supplementing module and the gas provided by the gas supplementing module are received through the mixing tank, so that the cleaning solution and the gas received by the mixing tank are mixed to form a gas-liquid mixture, and the module to be cleaned is cleaned through the gas-liquid mixture.
Second embodiment of sample analyzer control method
Further limiting the first embodiment of the sample analyzer control method, a second embodiment of the sample analyzer is provided, which is further defined as follows: as shown in fig. 1, the mixing tank 130 is of a closed structure, and the mixing tank 130 is respectively connected with a cleaning solution supplementing module 150, a gas supplementing module 140, a sample supplementing module 110, a reagent supplementing module 120 and a module to be cleaned 160. The mixing tank 130 is provided with an exhaust port 103, and the liquid surface of the mixing tank 130 when the gas-liquid mixture is formed is lower than the exhaust port 103.
As shown in fig. 1, the sample analyzer 100 includes a second control valve 192, and the second control valve 192 is connected in series to the exhaust port 103; the second control valve 192 is used for being opened when the gas provided by the gas supplementing module 140 received by the mixing tank 130 mixes the sample liquid and the reagent received by the mixing tank 130, so that the gas received by the mixing tank 130 is discharged through the gas outlet 103 after the sample liquid and the reagent received by the mixing tank 130 are mixed, and is used for being closed when the gas provided by the gas supplementing module 140 received by the mixing tank 130 is mixed with the cleaning liquid provided by the cleaning liquid supplementing module 150 received by the mixing tank 130, so that the gas received by the mixing tank 130 is dispersed and distributed in the cleaning liquid received by the mixing tank 130, so as to form a gas-liquid mixture.
In this way, in the process of preparing the sample, the second control valve 192 is opened to connect the mixing tank 130 and the air outlet 103, so that the air supplementing module 140 provides air into the mixing tank 130 to mix the sample liquid and the reagent in the mixing tank 130; in addition, when the gas-liquid mixture is formed, the second control valve 192 is closed, so that when the gas replenishing module 140 supplies the gas into the mixing tank 130, the gas in the mixing tank 130 is not leaked out, so that the pressure in the mixing tank 130 is increased, the gas in the gas-liquid mixture is not easy to overflow from the cleaning liquid, and the dispersion state of the gas in the gas-liquid mixture in the cleaning liquid can be maintained.
In other embodiments (not shown), the mixing tank is of an open structure, and the mixing tank is respectively connected with the cleaning solution supplementing module, the gas supplementing module, the reagent supplementing module and the module to be cleaned. The sample supplementing device can be a sampling needle, and the sampling needle can move for sampling, so that the collected sample liquid is injected into the mixing pool when the sample analyzer is in a detection working mode.
Further, referring to fig. 6, fig. 6 is a flowchart illustrating a step S400 in a second embodiment of a control method of the sample analyzer of the present application. Step S400 includes steps S410 to S430.
Step S410: the cleaning solution provided by the cleaning solution supplementing module and the gas provided by the gas supplementing module are received through the mixing tank, so that the cleaning solution and the gas received by the mixing tank are mixed to form a gas-liquid mixture.
Step S420: and guiding the gas-liquid mixture to the module to be cleaned through the mixing pool so as to clean the module to be cleaned.
Step S430: and opening the first control valve to enable the gas-liquid mixture after the module to be cleaned is cleaned to be discharged through the waste liquid discharge port.
In one example, as shown in fig. 1-2, the negative pressure driving part 180 is used to drive the gas-liquid mixture to be discharged through the opened first control valve 191 after the gas-liquid mixture is washed out of the module 160 to be washed.
In other embodiments, the mixing tank 130 is connected to the cleaning solution replenishment module 150, the gas replenishment module 140, the sample replenishment module 110, the reagent replenishment module 120, and the module to be cleaned 160, respectively. The cleaning solution replenishing module 150 is connected to the mixing tank 130 through a connecting pipeline between the mixing tank 130 and the module 160 to be cleaned.
Third embodiment of a control method for a sample analyzer
Further limiting the second embodiment of the control method of the sample analyzer, a third embodiment of the sample analyzer is provided, and further limiting that, as shown in fig. 1, the sample analyzer 100 includes a seventh control valve 197, the seventh control valve 197 is connected in series between the cleaning solution replenishing module 150 and the mixing tank 130, referring to fig. 7-8, and fig. 7 is a schematic flow chart of step S410 in the third embodiment of the control method of the sample analyzer of the present application; fig. 8 is a flowchart of step S420 in a third embodiment of a control method of the sample analyzer of the present application. Step S410 includes steps S411a to S412a, and step S420 includes steps S421a to S422a.
The step S310 specifically includes: and closing the third control valve, opening the fourth control valve and the fifth control valve, and receiving the sample liquid provided by the sample supplementing module and the reagent provided by the reagent supplementing module through the mixing pool so as to lift the liquid level in the mixing pool to be higher than the air supplementing interface.
The step S320 specifically includes: closing the fourth control valve and the fifth control valve, intermittently opening the sixth control valve, and receiving gas intermittently provided by the gas supplementing module at one or more preset interval time intervals based on the first gas supplementing parameter through the mixing tank so as to mix the sample liquid and the reagent received by the mixing tank uniformly to form a sample; the first make-up parameter includes a time for each make-up gas, a time interval between two adjacent make-up gases, and a driving gas pressure for each make-up gas.
Step S411a: and closing the third control valve, and opening the seventh control valve, and receiving the cleaning liquid provided by the cleaning liquid supplementing module through the mixing tank so as to lift the liquid level in the mixing tank to be higher than the air supplementing interface.
Step S412a: intermittently opening a sixth control valve, and receiving gas supplied intermittently by the gas supplementing module based on the second gas supplementing parameter at one or more preset time intervals through the mixing tank so as to mix with the cleaning solution received by the mixing tank, thereby forming a gas-liquid mixture.
The second air supplementing parameter in step S412a includes a time of each supplementing air, a time interval between two adjacent supplementing air, and a driving air pressure of each supplementing air, and is different from the first air supplementing parameter.
The second air supplementing parameter comprises time of supplementing air each time, time interval of two adjacent supplementing air and driving air pressure of supplementing air each time; the first supplemental air parameter is different from the second supplemental air parameter. In an example, the time interval between two adjacent supplemental gases in the first supplemental gas parameter is smaller than the time interval between two adjacent supplemental gases in the second supplemental gas parameter, and the driving gas pressure of each supplemental gas in the second supplemental gas parameter is a random number of the specified gas pressure range. So that the gas received by the mixing tank can be uniformly dispersed into the cleaning liquid received by the mixing tank when the gas-liquid mixture is formed.
Through the mode, when the gas is supplemented into the mixing tank based on the first air supplementing parameter, the time interval between two adjacent supplementing gases in the first air supplementing parameter is small, the amount of each supplementing gas is large, and the gas is easy to overflow from the cleaning liquid, so that the gas cannot remain in the cleaning liquid, when the gas is supplemented into the mixing tank based on the second air supplementing parameter, the time interval between two adjacent supplementing gases in the second air supplementing parameter is large, the amount of each supplementing gas is small, and therefore gas phases formed in the cleaning liquid by different supplementing gases are not easy to fuse, and the gas supplemented by different times can be stably dispersed in the cleaning liquid.
Step S421a: and closing the seventh control valve, opening the third control valve, and guiding the gas-liquid mixture to the module to be cleaned through the mixing pool.
Step S422a: and closing the third control valve, and cleaning the module to be cleaned by using the gas-liquid mixture.
Fourth embodiment of a method for controlling a sample analyzer
Further limiting the second embodiment of the sample analyzer control method, a fourth embodiment of the sample analyzer is provided, which is further limited in that, as shown in fig. 2, the mixing tank 130 is in a closed structure, the module to be cleaned 160 is respectively connected to the cleaning solution supplementing module 150 and the mixing tank 130, and the mixing tank 130 is respectively connected to the gas supplementing module 140, the sample supplementing module 110 and the reagent supplementing module 120.
The cleaning solution received by the mixing tank 130 enters the mixing tank 130 through the cleaning solution supplementing module 150 and the module 160 to be cleaned, so that the cleaning solution received by the mixing tank 130 is mixed with the gas to form a gas-liquid mixture.
Through the ascending mode, the cleaning solution provided by the cleaning solution supplementing module 150 can perform primary cleaning on the module 160 to be cleaned when passing through the module 160 to be cleaned, and after the gas and the liquid are mixed in the mixing tank 130 and the gas provided by the gas supplementing module 140 to form a gas-liquid mixture, the gas-liquid mixture performs secondary cleaning on the module 160 to be cleaned. In this way, the module 160 to be cleaned can be cleaned for a plurality of times, and the cleaning effect is better.
As shown in fig. 2, the cleaning solution received by the mixing tank 130 is fed into the mixing tank 130 through the module to be cleaned 160 by the cleaning solution supplementing module 150, so that the cleaning solution received by the mixing tank 130 is mixed with the gas to form a gas-liquid mixture.
Further, as shown in fig. 2, the sample analyzer 100 includes a second control valve 192, and the second control valve 192 is connected in series to the exhaust port 103; the second control valve 192 is used for being opened when the gas received by the mixing tank 130 and supplied by the gas supplementing module 140 mixes the sample liquid and the reagent received by the mixing tank 130, so as to be discharged after the gas received by the mixing tank 130 mixes the sample liquid and the reagent received by the mixing tank 130, and is used for being closed when the gas received by the mixing tank 130 and supplied by the gas supplementing module 140 is mixed with the cleaning liquid supplied by the cleaning liquid supplementing module 150 received by the mixing tank 130, so that the gas received by the mixing tank 130 is dispersed and distributed in the cleaning liquid received by the mixing tank 130, so as to form a gas-liquid mixture.
In other examples (not shown), the mixing tank is of an open structure, the module to be cleaned is respectively connected with the cleaning solution supplementing module and the mixing tank, the mixing tank is respectively connected with the gas supplementing module, the sample supplementing module and the reagent supplementing module, and the mixing tank is respectively connected with the gas supplementing module and the reagent supplementing module. The sample supplementing device can be a sampling needle, and the sampling needle can move for sampling, so that the collected sample liquid is injected into the mixing pool when the sample analyzer is in a detection working mode.
The step S400 specifically includes: the cleaning solution and the gas supplied by the cleaning solution supplying module through the cleaning solution to be cleaned and the gas supplied by the gas supplying module are received through the mixing tank, so that the cleaning solution and the gas received by the mixing tank are mixed to form a gas-liquid mixture, and the cleaning module to be cleaned is cleaned through the gas-liquid mixture.
Fifth embodiment of control method for sample analyzer
Further limiting the second embodiment of the control method of the sample analyzer, a fifth embodiment of the sample analyzer is provided, and further limiting that, as shown in fig. 2, the sample analyzer 100 includes a seventh control valve 197, the seventh control valve 197 is connected in series between the cleaning solution supplementing module 150 and the module 160 to be cleaned, referring to fig. 9-10, and fig. 9 is a schematic flow chart of step S410 in the fifth embodiment of the control method of the sample analyzer of the present application; fig. 10 is a flowchart of step S420 in a fifth embodiment of a control method of the sample analyzer of the present application. Step S410 includes steps S411b to S414b, and step S420 includes steps S421b to S422b.
Step S411b: and opening the seventh control valve, closing the third control valve, and providing cleaning liquid to the module to be cleaned through the cleaning liquid supplementing module.
Step S412b: and closing the seventh control valve to perform primary cleaning on the module to be cleaned through cleaning liquid in the module to be cleaned.
Step S413b: and opening a third control valve, and receiving the cleaning liquid in the module to be cleaned through the mixing tank so as to lift the liquid level in the mixing tank to be higher than the air supplementing interface.
Step S414b: and closing the third control valve, intermittently opening the sixth control valve, and receiving gas intermittently provided by the gas supplementing module based on the second gas supplementing parameter at one or more preset time intervals through the mixing tank so as to mix with the cleaning solution received by the mixing tank, thereby forming a gas-liquid mixture.
The second air supplementing parameter comprises time of supplementing air each time, time interval of two adjacent supplementing air and driving air pressure of supplementing air each time; the first supplemental air parameter is different from the second supplemental air parameter. In an example, the time interval between two adjacent supplementary gases in the first supplementary parameter is smaller than the time interval between two adjacent supplementary gases in the second supplementary parameter, the amount of gas in each supplementary in the first supplementary parameter is larger than the amount of gas in each supplementary in the second supplementary parameter, and the driving air pressure of each supplementary in the second supplementary parameter is a random number within a specified air pressure range. So that the gas received by the mixing tank can be uniformly dispersed into the cleaning liquid received by the mixing tank when the gas-liquid mixture is formed.
Through the mode, when the gas is supplemented into the mixing tank based on the first air supplementing parameter, the time interval between two adjacent supplementing gases in the first air supplementing parameter is small, the amount of each supplementing gas is large, and the gas is easy to overflow from the cleaning liquid, so that the gas cannot remain in the cleaning liquid, when the gas is supplemented into the mixing tank based on the second air supplementing parameter, the time interval between two adjacent supplementing gases in the second air supplementing parameter is large, the amount of each supplementing gas is small, and therefore gas phases formed in the cleaning liquid by different supplementing gases are not easy to fuse, and the gas supplemented by different times can be stably dispersed in the cleaning liquid.
Step S421b: and opening the third control valve, closing the sixth control valve, and providing the gas-liquid mixture for the module to be cleaned through the mixing pool.
Step S422b: and closing the third control valve, and cleaning the module to be cleaned again by the gas-liquid mixture in the module to be cleaned.
Through the ascending mode, the cleaning solution provided by the cleaning solution supplementing module 150 can perform primary cleaning on the module 160 to be cleaned when passing through the module 160 to be cleaned, and after the gas and the liquid are mixed in the mixing tank 130 and the gas provided by the gas supplementing module 140 to form a gas-liquid mixture, the gas-liquid mixture performs secondary cleaning on the module 160 to be cleaned. In this way, the module 160 to be cleaned can be cleaned for a plurality of times, and the cleaning effect is better.
Sixth embodiment of a control method for a sample analyzer
Further limiting the second embodiment of the sample analyzer control method described above, a sixth embodiment of the sample analyzer is provided, which is further limited in that, as shown in fig. 1-2, the sample analyzer includes an oscillation module 170, and the oscillation module 170 communicates with the module 160 to be cleaned.
The cleaning of the module to be cleaned in step S420 includes: and the oscillating module enables the gas-liquid mixture in the module to be cleaned to pass in and out so as to enable the gas-liquid mixture to oscillate in the module to be cleaned. In this way, the reagent attached in the module to be cleaned can be further promoted to fall off by the oscillation of the gas-liquid mixture in the module to be cleaned.
Specifically, as shown in fig. 1-2, the sample analyzer includes an eighth control valve 198, the eighth control valve 198 being connected in series between the oscillation module 170 and the module 160 to be cleaned.
For example, as shown in fig. 1-2, the oscillation module 170 may be used to alternately generate negative and positive pressures. In one embodiment, the oscillating module 170 may open the eighth control valve 198 to pump the gas-liquid mixture in the module 160 to be cleaned when the negative pressure is generated, and push the pumped gas-liquid mixture into the module 160 to be cleaned when the positive pressure is generated. In another embodiment, the oscillation module 170 may push the gas-liquid mixture in the module to be cleaned 160 into the mixing tank 130 when positive pressure is generated, and draw the gas-liquid mixture in the mixing tank 130 into the module to be cleaned 160 when negative pressure is generated.
The foregoing is only the embodiments of the present application, and is not intended to limit the scope of the patent application, and all equivalent structures or equivalent processes using the descriptions and the contents of the present application or other related technical fields are included in the scope of the patent application.
Claims (10)
1. The sample analyzer is characterized by comprising a sample detection working mode and a cleaning working mode, and comprises a sample supplementing module, a reagent supplementing module, a mixing pool, a gas supplementing module, a cleaning solution supplementing module and a module to be cleaned;
when the sample analyzer is in the sample detection working mode, the mixing tank is used for receiving the sample liquid provided by the sample supplementing module, the reagent provided by the reagent supplementing module and the gas provided by the gas supplementing module, so that the gas received by the mixing tank mixes the sample liquid and the reagent received by the mixing tank uniformly to form a sample;
when the sample analyzer is in the cleaning working mode, the mixing tank is used for receiving the cleaning solution provided by the cleaning solution supplementing module and the gas provided by the gas supplementing module, so that the cleaning solution and the gas received by the mixing tank are mixed to form a gas-liquid mixture, the module to be cleaned is further cleaned through the gas-liquid mixture,
The to-be-cleaned module is provided with a waste liquid discharge port, and the sample analyzer comprises a first control valve which is connected in series with the waste liquid discharge port; the first control valve is used for discharging the gas-liquid mixture in the module to be cleaned through the waste liquid discharge port after the gas-liquid mixture cleans the module to be cleaned,
the sample analyzer comprises a negative pressure driving component which is connected with the waste liquid discharge port and the first control valve in series and is used for driving the gas-liquid mixture to be discharged through the opened first control valve after the gas-liquid mixture is washed out of the module to be washed,
the negative pressure driving part drives the gas-liquid mixture in the module to be cleaned to be discharged through the opened first control valve after the gas-liquid mixture cleans the module to be cleaned, wherein the discharging speed of the gas-liquid mixture in the module to be cleaned is larger than the speed of the mixing tank for guiding the gas-liquid mixture to the module to be cleaned before the gas-liquid mixture cleans the module to be cleaned.
2. The sample analyzer of claim 1, wherein the mixing tank receives gas intermittently provided by the gas replenishment module at one or more predetermined time intervals based on a second replenishment parameter to mix with cleaning liquid received by the mixing tank to form the gas-liquid mixture while the sample analyzer is in the cleaning mode of operation; the second air supplementing parameter comprises time of supplementing air each time, time interval of two adjacent supplementing air and driving air pressure of supplementing air each time.
3. The sample analyzer of claim 2, wherein the sample analyzer comprises a sample cell,
the driving air pressure of each supplementary air in the second air supplementing parameters is a random number in a specified air pressure range.
4. A sample analyzer according to claim 2 or 3, characterized in that,
the mixing pool is of a closed structure, the mixing pool is provided with an exhaust port, and the liquid level of the mixing pool when the gas-liquid mixture is formed is lower than the exhaust port;
the sample analyzer comprises a second control valve, and the second control valve is connected in series with the exhaust port; the second control valve is used for being opened when the mixing tank receives the gas provided by the gas supplementing module to mix the sample liquid and the reagent received by the mixing tank, so that the gas received by the mixing tank is discharged through the exhaust port after being mixed, and is used for being closed when the gas provided by the gas supplementing module is received by the mixing tank to be mixed with the cleaning liquid provided by the cleaning liquid supplementing module received by the mixing tank, so that the gas received by the mixing tank is dispersed and distributed in the cleaning liquid received by the mixing tank, and the gas-liquid mixture is formed.
5. The sample analyzer of claim 1, comprising an oscillation module in communication with the module to be cleaned,
the oscillating module enables the gas-liquid mixture in the module to be cleaned to pass in and out, so that the gas-liquid mixture oscillates in the module to be cleaned.
6. The sample analyzer of claim 1, wherein the sample analyzer comprises a sample cell,
the module to be cleaned is respectively connected with the cleaning solution supplementing module and the mixing pool,
the mixing pool is respectively connected with the gas supplementing module, the sample supplementing module and the reagent supplementing module,
or the mixing tank is respectively connected with the gas supplementing module and the reagent supplementing module;
wherein, the liquid crystal display device comprises a liquid crystal display device,
and the cleaning liquid received by the mixing tank enters the mixing tank from the cleaning liquid supplementing module through the module to be cleaned, so that the cleaning liquid received by the mixing tank is mixed with gas to form the gas-liquid mixture.
7. The sample analyzer of claim 6, wherein the sample analyzer comprises a sample cell,
the sample analyzer comprises a third control valve, a fourth control valve, a fifth control valve, a sixth control valve and a seventh control valve,
The third control valve is connected in series between the mixing pool and the module to be cleaned,
the fourth control valve is connected in series between the sample supplementing module and the mixing pool,
the fifth control valve is connected in series between the reagent supplementing module and the mixing pool,
the sixth control valve is connected in series between the gas supplementing module and the mixing pool,
the seventh control valve is connected in series between the cleaning solution supplementing module and the mixing pool,
or the seventh control valve is connected in series between the cleaning solution supplementing module and the module to be cleaned.
8. A control method of a sample analyzer, characterized in that the control method is applied to the sample analyzer according to any one of claims 1 to 7, the sample analyzer comprises a fourth control valve, a fifth control valve and a sixth control valve, the fourth control valve is connected in series between the sample supplementing module and the mixing tank, the fifth control valve is connected in series between the reagent supplementing module and the mixing tank, the sixth control valve is connected in series between the gas supplementing module and the mixing tank, and the sample analyzer is provided with a sample detection working mode and a cleaning working mode in advance; the control method comprises the following steps:
Switching to a corresponding one of the sample detection working mode and the cleaning working mode according to a working mode setting instruction;
when switching to the sample detection operation mode, performing a sample preparation step, the sample preparation step comprising: receiving the sample liquid provided by the sample supplementing module and the reagent provided by the reagent supplementing module through a mixing pool;
closing the fourth control valve and the fifth control valve, intermittently opening the sixth control valve, and receiving gas intermittently provided by the gas supplementing module at one or more preset interval time intervals based on a first gas supplementing parameter through the mixing tank so as to mix the sample liquid and the reagent received by the mixing tank uniformly to form the sample; the first air supplementing parameter comprises time of supplementing air each time, time interval of two adjacent supplementing air and driving air pressure of supplementing air each time.
9. A method of cleaning a sample analyzer according to any one of claims 1 to 7, wherein the sample analyzer includes a third control valve and a sixth control valve, the third control valve being connected in series between the mixing tank and the module to be cleaned, the sixth control valve being connected in series between the gas replenishment module and the mixing tank, the method comprising:
The cleaning solution provided by the cleaning solution supplementing module and the gas provided by the gas supplementing module are received through the mixing tank, so that the cleaning solution and the gas received by the mixing tank are mixed to form a gas-liquid mixture; opening the third control valve, closing the sixth control valve, and providing the gas-liquid mixture to the module to be cleaned through the mixing pool;
and closing the third control valve, and cleaning the module to be cleaned again through the gas-liquid mixture in the module to be cleaned.
10. A method for cleaning a sample analyzer according to any one of claims 1 to 7, wherein the sample analyzer comprises a third control valve, a sixth control valve and a seventh control valve, the third control valve is connected in series between the mixing tank and the module to be cleaned, the sixth control valve is connected in series between the gas supplementing module and the mixing tank, and the seventh control valve is connected in series between the cleaning liquid supplementing module and the module to be cleaned; the to-be-cleaned module is respectively connected with the cleaning solution supplementing module and the mixing tank, the mixing tank is provided with a liquid outlet interface and a gas supplementing interface, and the height of the gas supplementing interface from the bottom of the mixing tank is smaller than the height of the top of the mixing tank from the bottom of the mixing tank; the gas supplementing module is connected with the gas supplementing interface, and the module to be cleaned is connected with the liquid outlet interface;
The method comprises the following steps:
opening the seventh control valve, closing the third control valve, and providing cleaning liquid to the module to be cleaned through the cleaning liquid supplementing module;
closing the seventh control valve to perform primary cleaning on the module to be cleaned through cleaning liquid in the module to be cleaned;
the third control valve is opened, and the cleaning liquid in the module to be cleaned is received through the mixing tank, so that the liquid level in the mixing tank is lifted to be higher than the air supplementing interface;
closing the third control valve, intermittently opening the sixth control valve, and receiving the gas intermittently provided by the gas supplementing module at one or more preset time intervals based on a second gas supplementing parameter through the mixing tank so as to mix with the cleaning solution received by the mixing tank, thereby forming the gas-liquid mixture; the second air supplementing parameters comprise time for supplementing air each time, time interval between two adjacent air supplementing times and driving air pressure of the air supplementing each time, and are different from the first air supplementing parameters, wherein the first air supplementing parameters are parameters that the air supplementing module intermittently provides air to the mixing pool at one or more preset interval time intervals;
And guiding the gas-liquid mixture to the module to be cleaned through the mixing pool so as to clean the module to be cleaned.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202211394501.3A CN116338218A (en) | 2022-06-13 | 2022-06-13 | Sample analyzer and control method for sample analyzer |
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202211394501.3A CN116338218A (en) | 2022-06-13 | 2022-06-13 | Sample analyzer and control method for sample analyzer |
| CN202210663276.2A CN114778872B (en) | 2022-06-13 | 2022-06-13 | Sample analyzer and control method of sample analyzer |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202210663276.2A Division CN114778872B (en) | 2022-06-13 | 2022-06-13 | Sample analyzer and control method of sample analyzer |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN116338218A true CN116338218A (en) | 2023-06-27 |
Family
ID=82421992
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202211394501.3A Pending CN116338218A (en) | 2022-06-13 | 2022-06-13 | Sample analyzer and control method for sample analyzer |
| CN202210663276.2A Active CN114778872B (en) | 2022-06-13 | 2022-06-13 | Sample analyzer and control method of sample analyzer |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202210663276.2A Active CN114778872B (en) | 2022-06-13 | 2022-06-13 | Sample analyzer and control method of sample analyzer |
Country Status (2)
| Country | Link |
|---|---|
| CN (2) | CN116338218A (en) |
| WO (1) | WO2023241019A1 (en) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114778868B (en) * | 2022-06-13 | 2022-11-22 | 深圳市帝迈生物技术有限公司 | Cleaning method of blood analyzer and blood analyzer |
| CN116338218A (en) * | 2022-06-13 | 2023-06-27 | 深圳市帝迈生物技术有限公司 | Sample analyzer and control method for sample analyzer |
| CN116106488A (en) * | 2023-04-13 | 2023-05-12 | 深圳市帝迈生物技术有限公司 | Sample analyzer |
Family Cites Families (45)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2446404C3 (en) * | 1974-09-28 | 1981-11-26 | Becker, Wolf-Jürgen, Dr., 6701 Fußgönheim | Device for sampling in flowing exhaust gases |
| JPH0763687B2 (en) * | 1986-06-11 | 1995-07-12 | 株式会社オ−・エイチ・エル | Article cleaning method and device |
| CN2038510U (en) * | 1988-11-24 | 1989-05-31 | 蔡枫 | Vacuum washing and drying clothes machine |
| JP4027492B2 (en) * | 1998-03-23 | 2007-12-26 | オリンパス株式会社 | Cleaning device |
| US8323984B2 (en) * | 2002-12-19 | 2012-12-04 | Beckman Coulter, Inc. | Method and apparatus for mixing blood samples for cell analysis |
| WO2007023205A1 (en) * | 2005-08-24 | 2007-03-01 | Telechemistry Oy | A method of testing a liquid sample, a test unit, and an automized system of a plurality of test units |
| DE102007040522A1 (en) * | 2007-08-28 | 2009-03-05 | Atec Pharmatechnik Gmbh | Method for washing smaller objects |
| JP2010172786A (en) * | 2009-01-27 | 2010-08-12 | Nsi:Kk | Apparatus and method for washing piping to be washed |
| JP2010284572A (en) * | 2009-06-09 | 2010-12-24 | Rix Corp | Washing method, and washing apparatus |
| JP5600910B2 (en) * | 2009-08-31 | 2014-10-08 | セイコーエプソン株式会社 | Liquid ejecting apparatus and method for cleaning liquid ejecting head in liquid ejecting apparatus |
| JP2011218308A (en) * | 2010-04-12 | 2011-11-04 | Asupu:Kk | Gas-dissolved liquid generating apparatus and method for generation |
| WO2011149031A1 (en) * | 2010-05-27 | 2011-12-01 | Matsumura Eiji | Liquid clathrate having gas molecules dissolved at high density |
| CN102735829B (en) * | 2012-07-20 | 2013-08-14 | 深圳市麦迪聪医疗电子有限公司 | Blood gas analyzer and using method thereof |
| CN103785642B (en) * | 2012-11-05 | 2016-11-09 | 内蒙古伊利实业集团股份有限公司 | Parts automatically clean, dry and sterilizing installation |
| CN104297023B (en) * | 2013-07-16 | 2017-05-24 | 成都深迈瑞医疗电子技术研究院有限公司 | A cell analyzer, a mixing device thereof and a mixing method |
| JP6334112B2 (en) * | 2013-08-23 | 2018-05-30 | 株式会社日立ハイテクノロジーズ | Automatic analyzer |
| CN103439139B (en) * | 2013-09-13 | 2015-08-19 | 四川沃文特生物技术有限公司 | Disposable specimen harvester pipe and application process thereof |
| CN104127192B (en) * | 2013-10-16 | 2016-08-10 | 深圳市帝迈生物技术有限公司 | A kind of flow cytometer fluid system and FCM analysis method |
| CN104889126B (en) * | 2015-06-01 | 2016-10-05 | 阿拉山口出入境检验检疫局综合技术服务中心 | Experiment appliance wash mill |
| CN105572407B (en) * | 2016-01-27 | 2018-01-16 | 广州万孚生物技术股份有限公司 | Full-automatic fluorescent quantitation immunity analysis instrument and detection method |
| CN206344348U (en) * | 2016-08-31 | 2017-07-21 | 山东豪迈机械科技股份有限公司 | A kind of tire-mold steam chest cleaning device |
| CN207086485U (en) * | 2017-07-06 | 2018-03-13 | 徐工集团工程机械有限公司 | Pipeline washing device and concrete conveying equipment |
| CN208116321U (en) * | 2018-01-23 | 2018-11-20 | 苏州卫水环保科技有限公司 | Water quality online analyzer water sample pipeline cleaning system |
| CN108414338A (en) * | 2018-02-02 | 2018-08-17 | 迪瑞医疗科技股份有限公司 | A kind of bubble evenly mixing device |
| CN110270564B (en) * | 2018-03-15 | 2022-06-10 | 深圳迈瑞生物医疗电子股份有限公司 | Reactant cleaning method and sample analyzer |
| CN108480314A (en) * | 2018-06-09 | 2018-09-04 | 重庆医科大学附属永川医院 | Silver tracheal catheter cleaning machine |
| CN109092758B (en) * | 2018-07-24 | 2020-04-07 | 老肯医疗科技股份有限公司 | Negative pressure cleaning machine and method for cleaning and disinfecting by using same |
| CN110180817B (en) * | 2019-05-29 | 2023-09-08 | 西安热工研究院有限公司 | Multiphase flow cleaning device and cleaning method for solid-state electrode in chemical instrument |
| CN214310556U (en) * | 2019-09-11 | 2021-09-28 | 深圳迈瑞生物医疗电子股份有限公司 | Sample analyzer |
| CN211538808U (en) * | 2019-11-28 | 2020-09-22 | 深圳市镭神智能系统有限公司 | Cleaning device and optical sensor system |
| CN111024481A (en) * | 2019-12-30 | 2020-04-17 | 深圳开立生物医疗科技股份有限公司 | Sample mixing method and sample analyzer |
| JP7451252B2 (en) * | 2020-03-23 | 2024-03-18 | キヤノンメディカルシステムズ株式会社 | automatic analyzer |
| CN111482418A (en) * | 2020-05-20 | 2020-08-04 | 洛阳理工学院 | Gas-liquid coupling type long-distance pipeline cleaning device and method thereof |
| CN113866432A (en) * | 2020-06-30 | 2021-12-31 | 深圳迈瑞生物医疗电子股份有限公司 | Sample detection equipment and method thereof |
| CN113917165A (en) * | 2020-07-10 | 2022-01-11 | 深圳市帝迈生物技术有限公司 | POCT sample analyzer and detection method thereof |
| CN111912743A (en) * | 2020-07-10 | 2020-11-10 | 中国石油大学胜利学院 | Gas-liquid two-phase jet flow oil pipe outer surface cleaning experimental device and method |
| KR102219833B1 (en) * | 2020-07-20 | 2021-02-24 | 마이크로어낼리시스 (주) | Automatic measurement apparatus for analysis of liquid samples and sample analysis method using the same |
| CN111855321A (en) * | 2020-07-20 | 2020-10-30 | 枣庄惠风能源科技有限公司 | Dust extraction mechanism in desulfurized flue gas, dust measurement device and method |
| CN112452959B (en) * | 2020-09-22 | 2022-07-01 | 潍坊嘉腾液压技术有限公司 | Pipeline cleaning device and cleaning method |
| WO2022104730A1 (en) * | 2020-11-20 | 2022-05-27 | 深圳市科曼医疗设备有限公司 | Method and apparatus for testing sample absorption of sample analyzer |
| CN215142779U (en) * | 2021-06-03 | 2021-12-14 | 浙江迈尔医疗技术有限公司 | Cleaning heat exchange cabin and medical cleaning and disinfecting equipment |
| CN114226345A (en) * | 2021-11-02 | 2022-03-25 | 深圳市鑫承诺环保产业股份有限公司 | Cleaning process and cleaning system for paint spraying shielding case |
| CN114778868B (en) * | 2022-06-13 | 2022-11-22 | 深圳市帝迈生物技术有限公司 | Cleaning method of blood analyzer and blood analyzer |
| CN114778870A (en) * | 2022-06-13 | 2022-07-22 | 深圳市帝迈生物技术有限公司 | Sample analyzer and cleaning method thereof |
| CN116338218A (en) * | 2022-06-13 | 2023-06-27 | 深圳市帝迈生物技术有限公司 | Sample analyzer and control method for sample analyzer |
-
2022
- 2022-06-13 CN CN202211394501.3A patent/CN116338218A/en active Pending
- 2022-06-13 CN CN202210663276.2A patent/CN114778872B/en active Active
- 2022-12-31 WO PCT/CN2022/144425 patent/WO2023241019A1/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CN114778872A (en) | 2022-07-22 |
| CN114778872B (en) | 2022-11-29 |
| WO2023241019A1 (en) | 2023-12-21 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN116338218A (en) | Sample analyzer and control method for sample analyzer | |
| US8118042B2 (en) | Apparatus and method for cleaning a liquid handling probe | |
| EP0661542A2 (en) | Pipet washing apparatus | |
| CN110320379B (en) | Sample analyzer and cleaning method thereof | |
| JPH0755817A (en) | Device and method for analyzing capsuled chemical sample liquid | |
| CN110434128B (en) | Sampling needle cleaning device and cleaning method | |
| JPWO2014175018A1 (en) | Automatic analyzer | |
| JP2005241442A (en) | Cleaning device and method, and analyzer using it | |
| JP7451252B2 (en) | automatic analyzer | |
| CN113866432A (en) | Sample detection equipment and method thereof | |
| CN114778868B (en) | Cleaning method of blood analyzer and blood analyzer | |
| JP6249626B2 (en) | Automatic analyzer | |
| CN111024481A (en) | Sample mixing method and sample analyzer | |
| CN114778870A (en) | Sample analyzer and cleaning method thereof | |
| CN112683887B (en) | Device and method for discharging and drying waste liquid of chemiluminescence instrument | |
| CN110320380B (en) | Automatic analysis device and automatic analysis method | |
| JP2008128662A (en) | Analyzer | |
| CN112881723A (en) | Blood detection device and blood detection method | |
| CN214503378U (en) | A device that is used for chemiluminescent instrument's waste liquid to discharge and weathers | |
| JPH04105065A (en) | Cup washing device | |
| JPH0540123A (en) | Method and apparatus for agitating and sucking sample | |
| JP6355960B2 (en) | CLINICAL INSPECTION DEVICE AND CONTAINER CLEANING METHOD | |
| JPH07174765A (en) | Dispenser | |
| JP2005283246A (en) | Nozzle washing method and apparatus | |
| JP3752653B2 (en) | Sample dilution method and apparatus |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination |