CN110434128B - Sampling needle cleaning device and cleaning method - Google Patents
Sampling needle cleaning device and cleaning method Download PDFInfo
- Publication number
- CN110434128B CN110434128B CN201810411541.1A CN201810411541A CN110434128B CN 110434128 B CN110434128 B CN 110434128B CN 201810411541 A CN201810411541 A CN 201810411541A CN 110434128 B CN110434128 B CN 110434128B
- Authority
- CN
- China
- Prior art keywords
- cleaning
- sampling needle
- needle
- pool
- wall
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Images
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B08—CLEANING
- B08B—CLEANING IN GENERAL; PREVENTION OF FOULING IN GENERAL
- B08B9/00—Cleaning hollow articles by methods or apparatus specially adapted thereto
- B08B9/02—Cleaning pipes or tubes or systems of pipes or tubes
- B08B9/023—Cleaning the external surface
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B08—CLEANING
- B08B—CLEANING IN GENERAL; PREVENTION OF FOULING IN GENERAL
- B08B9/00—Cleaning hollow articles by methods or apparatus specially adapted thereto
- B08B9/02—Cleaning pipes or tubes or systems of pipes or tubes
- B08B9/027—Cleaning the internal surfaces; Removal of blockages
- B08B9/032—Cleaning the internal surfaces; Removal of blockages by the mechanical action of a moving fluid, e.g. by flushing
- B08B9/0321—Cleaning the internal surfaces; Removal of blockages by the mechanical action of a moving fluid, e.g. by flushing using pressurised, pulsating or purging fluid
Landscapes
- Engineering & Computer Science (AREA)
- Mechanical Engineering (AREA)
- Automatic Analysis And Handling Materials Therefor (AREA)
- Sampling And Sample Adjustment (AREA)
Abstract
The invention discloses a sampling needle cleaning device and a cleaning method, wherein the device comprises a cleaning pool, a needle point cleaning module and a sampling needle inner wall cleaning module, wherein the needle point cleaning module is communicated with an interface on the side wall of the cleaning pool and is used for conveying cleaning liquid to the cleaning pool to clean the needle point of a sampling needle; the sampling needle inner wall cleaning module is communicated with the sampling needle and used for driving cleaning liquid to carry out reciprocating cleaning on the inner wall of the sampling needle; the method comprises the following steps: extending the sampling needle into the cleaning pool, and enabling the needle point to be positioned below the communication part of the interface and the cleaning pool; introducing a first cleaning solution into the cleaning pool to wash the needle tip of the sampling needle; extracting a first cleaning liquid and driving the first cleaning liquid to perform reciprocating cleaning on the inner wall of the sampling needle; the device has the advantages of simple structure, convenient operation, no need of complex liquid path time sequence, and capability of comprehensively and thoroughly cleaning the inside and the outside of the sampling needle and the needle tip by matching with a swab in the prior art, thereby avoiding carrying pollution.
Description
Technical Field
The invention relates to the technical field of sample analysis, in particular to a sampling needle cleaning device and a cleaning method.
Background
After a sampling needle of the sample analyzer absorbs a blood sample from a blood collection tube, the sampling needle needs to be cleaned, otherwise, the sample can be remained on the inner wall, the outer wall and the needle point of the sampling needle, and the carrying pollution is caused to the next sampling and detection. Compared with blood cells, the residues formed on the inner wall, the outer wall and the needle tip of the sampling needle by proteins, such as C-reactive protein (CRP), are more difficult to clean, because the volume of the proteins is smaller than that of the blood cells, and the nonspecific adsorption is formed due to the surface charge. That is, reducing the protein carrying pollution, especially the high-value sample carrying pollution, is a problem faced by the blood cell-protein combined detection instrument on the market at present.
The principle of a sampling needle cleaning device adopted by an analyzer for combined detection of hemocyte and protein in the market at present is basically the same, namely, a sampling needle washing device (swab) is provided with an inlet and an outlet of diluent, the diluent is introduced into the swab from the inlet, negative pressure is introduced into the outlet to suck the diluent away, and the diluent finishes cleaning the sampling needle in the movement process of the inside of the swab.
Although the sampling needle flushing device can achieve a certain effect in the aspect of reducing carrying pollution, the following problems still exist, one is that the inner wall of the sampling needle cannot be well cleaned, because the flow rate of diluent for cleaning the inner wall of the sampling needle must be matched with the flow rate of diluent for cleaning the outer wall in the swab, leakage can be formed at the bottom of the swab if the flow rate of the diluent for cleaning the inner wall of the sampling needle is too high, and the inner wall of the sampling needle cannot be thoroughly cleaned if the flow rate is too low; secondly, the inner wall cleaning by using the swab generally comprises the steps that diluent washes the inner wall of the sampling needle in a one-way mode, when a high-value sample is analyzed, only one-way washing cannot completely wash out protein which is small in size and strong in adhesive force with the inner wall of the sampling needle, because liquid flows in the needle to be approximate to laminar flow, the closer to the inner wall of the sampling needle, the smaller the flow velocity of the fluid is, the insufficient impact force is, and the cleaning effect is poor; thirdly, the needle point of sampling needle forms the sample very easily and remains, and is difficult to wash the needle point clean with the swab alone, especially when the sampling process need puncture, still can have some plug piece adhesion at the sampling needle point, is difficult to clear up.
Therefore, how to improve the device and method for cleaning the sampling needle to improve the cleaning effect on the inner wall and the needle tip of the sampling needle, reduce the residual sample at the above-mentioned position of the sampling needle, and further avoid carrying contamination becomes an important technical problem to be solved urgently by those skilled in the art.
Disclosure of Invention
In view of the above, a first object of the present invention is to provide a sampling needle cleaning device to improve the cleaning effect on the inner wall and the needle tip of the sampling needle, reduce the residual sample at the position of the sampling needle, and further avoid carrying contamination.
In order to achieve the purpose, the invention provides the following technical scheme:
a sampling needle cleaning device comprising:
a cleaning tank;
the needle point cleaning module is communicated with an interface on the side wall of the cleaning pool and is used for conveying cleaning liquid to the cleaning pool to clean the needle point of the sampling needle;
and the sampling needle inner wall cleaning module is communicated with the sampling needle and is used for driving the cleaning liquid to perform reciprocating cleaning on the inner wall of the sampling needle.
Preferably, the cross section of the cleaning pool is circular, and an interface on the side wall of the cleaning pool is communicated with the cleaning pool along the tangential direction of the cleaning pool.
Preferably, the interface on the side wall of the cleaning pool is inclined downwards.
Preferably, the needle tip cleaning module comprises a first pressure source and a first container for containing cleaning fluid, and the first pressure source extracts the cleaning fluid from the first container and sends the cleaning fluid to the cleaning pool.
Preferably, the first pressure source is a syringe pump, the needle tip cleaning module further includes a first control valve, the first container, the first pressure source and the interface on the side wall of the cleaning pool are all communicated with the first control valve, the first control valve can communicate the first container with the first pressure source in a first state, and the first control valve can communicate the first pressure source with the interface on the side wall of the cleaning pool in a second state.
Preferably, the sampling needle inner wall cleaning module comprises a second pressure source, one end of the sampling needle far away from the needle tip is communicated with the second pressure source, and the second pressure source can provide positive pressure and negative pressure to drive the cleaning liquid to move in a reciprocating manner.
Preferably, the sampling needle inner wall cleaning module further comprises a second control valve and a second container, one end of the sampling needle far away from the needle tip is communicated with the second pressure source through the second control valve, the second container is communicated with the second control valve, the second control valve can communicate the second container with the second pressure source in a first state, and the second control valve can communicate the second pressure source with one end of the sampling needle far away from the needle tip in a second state.
Preferably, still include sampling needle outer wall washing module, sampling needle outer wall washing module includes swab and washing liquid conveyor, the sampling needle follow the inner chamber of swab stretches out, just be provided with the import with the inner chamber intercommunication on the swab, washing liquid conveyor with the import intercommunication of swab.
Preferably, the bottom of the cleaning pool is provided with an outlet, and the outlet of the cleaning pool is communicated with a waste liquid conveying device.
A sampling needle cleaning method comprises the following steps:
1) the sampling needle is extended into the cleaning pool, and the needle point of the sampling needle is positioned below the communication position of the interface on the side wall of the cleaning pool and the cleaning pool;
2) introducing a first cleaning solution into the cleaning pool to wash the needle tip of the sampling needle;
3) and extracting the first cleaning liquid and driving the first cleaning liquid to reciprocate so as to clean the inner wall of the sampling needle in a reciprocating manner.
Preferably, the first cleaning liquid extracted in step 3) is the first cleaning liquid stored in the cleaning pool after the step 2) is completed, and the step 3) is to immerse the needle tip of the sampling needle in the first cleaning liquid in the cleaning pool and extract the first cleaning liquid in the cleaning pool to perform reciprocating cleaning on the inner wall of the sampling needle.
Preferably, the method further comprises the steps of:
4) and extracting the second cleaning liquid to clean the inner wall of the sampling needle so as to remove the residual first cleaning liquid.
Preferably, the method further comprises the steps of:
5) lifting the sampling needle into the swab and separating the sampling needle from the cleaning liquid in the cleaning pool, and introducing a second cleaning liquid into the swab to clean the outer wall of the sampling needle;
6) and emptying the waste liquid in the cleaning pool.
Preferably, if the first cleaning liquid is the same as the second cleaning liquid, directly entering the step 5) from the step 3)
Preferably, the first cleaning solution is a hemolytic agent, and the second cleaning solution is a diluent.
In order to achieve the first object, the sampling needle cleaning device provided by the invention comprises a cleaning pool, a needle point cleaning module and a sampling needle inner wall cleaning module, wherein the cleaning pool is used for receiving cleaning liquid, an opening for the sampling needle to enter and exit is formed at the upper end of the cleaning pool, and an interface for the cleaning liquid to enter is formed on the side wall of the cleaning pool; the needle point cleaning module is communicated with an interface on the side wall of the cleaning pool and is used for conveying cleaning liquid to the cleaning pool to clean the needle point of the sampling needle; the sampling needle inner wall cleaning module is communicated with the sampling needle and is used for driving cleaning fluid to carry out reciprocating cleaning on the inner wall of the sampling needle, the cleaning fluid used for cleaning the inner wall of the sampling needle in a reciprocating manner can be cleaning fluid accumulated in a cleaning pool after a needle point is cleaned, and other cleaning fluid can also be used;
in order to achieve the second object, the present invention further provides a sampling needle cleaning method based on the sampling needle cleaning device, including the steps of: 1) the sampling needle is extended into the cleaning pool, and the needle point of the sampling needle is positioned below the communication position of the interface on the side wall of the cleaning pool and the cleaning pool; 2) introducing a first cleaning solution into the cleaning pool to wash the needle tip of the sampling needle; 3) extracting a first cleaning liquid and driving the first cleaning liquid to move in a reciprocating manner so as to clean the inner wall of the sampling needle in a reciprocating manner;
therefore, the device is simple in structure and convenient to operate, does not need complex liquid path time sequence, can fully clean the needle point and the inner wall of the sampling needle, reduces sample residues of the needle point and the inner wall of the sampling needle, is matched with a swab in the prior art, can comprehensively and thoroughly clean the inner wall, the outer wall and the needle point of the sampling needle, and avoids carrying pollution.
Drawings
In order to more clearly illustrate the embodiments of the present invention or the technical solutions in the prior art, the drawings used in the description of the embodiments or the prior art will be briefly described below, it is obvious that the drawings in the following description are only some embodiments of the present invention, and for those skilled in the art, other drawings can be obtained according to the drawings without creative efforts.
Fig. 1 is a schematic structural diagram of a sampling needle cleaning device provided in an embodiment of the present invention;
FIG. 2 is a top view of a cleaning tank of a sampling needle cleaning device provided in an embodiment of the present invention;
fig. 3 is a flowchart of a method for cleaning a sampling needle according to an embodiment of the present invention.
In the figure:
1 is a cleaning pool; 2 is an interface; 3 is a sampling needle; 4 is a swab; 5 is a second control valve; 6 is a third control valve; 7 is a first control valve; 8 is a first container; 9 is a second container; 10 is a first pressure source; 11 is a third pressure source; 12 is a second pressure source; 13 is a fourth control valve; 14 is a fifth control valve; and 15 is a waste liquid pump.
Detailed Description
The first purpose of the invention is to provide a sampling needle cleaning device, the structure of which can actually improve the cleaning effect on the inner wall and the needle point of the sampling needle, reduce the residual samples at the position of the sampling needle and further avoid carrying pollution.
The technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the drawings in the embodiments of the present invention, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
Referring to fig. 1, fig. 1 is a schematic structural diagram of a sampling needle cleaning device according to an embodiment of the present invention.
The embodiment of the invention provides a sampling needle cleaning device, which comprises a cleaning pool 1, a needle point cleaning module and a sampling needle inner wall cleaning module, wherein the cleaning pool 1 is used for receiving cleaning liquid, an opening for the sampling needle 3 to enter and exit is formed at the upper end of the cleaning pool, and an interface 2 for the cleaning liquid to enter is formed on the side wall of the cleaning pool; the needle point cleaning module is communicated with an interface 2 on the side wall of the cleaning pool 1 and is used for conveying cleaning liquid to the cleaning pool 1 to clean the needle point of the sampling needle 3; the sampling needle inner wall cleaning module is communicated with the sampling needle 3 and used for driving cleaning liquid to carry out reciprocating cleaning on the inner wall of the sampling needle 3, the cleaning liquid used for cleaning the inner wall of the sampling needle 3 in a reciprocating mode can be the cleaning liquid accumulated in the cleaning pool 1 after the needle point is cleaned, and other cleaning liquid can also be used.
Compared with the prior art, the sampling needle cleaning device provided by the invention has the advantages that the structure is simple, the operation is convenient, when in use, the needle point of the sampling needle 3 firstly extends into the cleaning pool 1, the needle point is ensured to be positioned below the communication part of the interface 2 on the side wall of the cleaning pool 1 and the cleaning pool 1, then the cleaning liquid is introduced into the cleaning pool 1 to flush the needle point of the sampling needle 3, the used cleaning liquid is accumulated in the cleaning pool 1 for the next cleaning or direct discharge, then the cleaning liquid is driven by the sampling needle inner wall cleaning module to carry out reciprocating flushing on the inner wall of the sampling needle 3, namely the cleaning liquid is driven to reciprocate in the sampling needle 3, the residual samples attached to the inner wall of the sampling needle 3 are flushed from two directions to improve the cleaning capability, the needle point and the inner wall of the sampling needle 3 can be sufficiently and effectively cleaned by the cleaning device, and the outer wall cleaning device in the prior art is matched, the inside and outside of the sampling needle 3 and the needle tip can be fully cleaned, and the carrying pollution is avoided.
Referring to fig. 2, fig. 2 is a top view of a cleaning tank of a sampling needle cleaning device according to an embodiment of the present invention, in the embodiment of the present invention, a cross section of the cleaning tank 1 is circular, an interface 2 on a side wall of the cleaning tank 1 is communicated with the cleaning tank 1 along a tangential direction of the cleaning tank 1, and through the above structure, a cleaning liquid for cleaning a needle tip is introduced into the cleaning tank 1 along the tangential direction, flows along a tank wall to form a vortex, increases a contact area between the cleaning liquid and the needle tip, and reduces splashing of the cleaning liquid, so that the cleaning liquid washes the needle tip of the sampling needle 3 at a high flow rate, thereby achieving thorough cleaning of the needle tip.
In the embodiment of the invention, the cleaning pool 1 is connected tangentially, and the port 2 on the side wall of the cleaning pool 1 is also connected with the cleaning pool 1 obliquely downwards, that is, when the needle point is cleaned, the flowing direction of the cleaning liquid is obliquely downwards, so that the needle point can be washed downwards, the residual sample is brought to the direction far away from the needle point, and the cleaning effect of the needle point is further improved.
The needle point cleaning module is used for providing cleaning liquid to the cleaning pool 1, the liquid supply mode can be continuous supply, continuous washing is formed on the needle point, for example, the cleaning liquid can be pumped by a water pump and supplied to the cleaning pool 1, or the cleaning liquid can be supplied for multiple times in a segmented mode, so that multiple impacts can be formed on the needle point, for example, a plunger pump can be used, a one-way ball valve structure is used in cooperation with the reciprocating movement of a piston, the cleaning liquid is pumped from a cleaning liquid container and then pushed into the cleaning pool 1, in the embodiment of the invention, the needle point cleaning module comprises a first pressure source 10 and a first container 8 for containing the cleaning liquid, the first pressure source 10 pumps the cleaning liquid from the first container 8 and sends the cleaning liquid to the cleaning pool 1, specifically, the first pressure source 10 is an injection pump, and can provide positive pressure and negative pressure and can store a certain amount of cleaning liquid, and further comprises a first control valve 7, the first container 8, the first pressure source 10 and the interface 2 on the side wall of the cleaning pool 1 are all communicated with the first control valve 7, the first control valve 7 can communicate the first container 8 with the first pressure source 10 in a first state, the first control valve 7 can communicate the first pressure source 10 with the interface 2 on the side wall of the cleaning pool 1 in a second state, when the cleaning pool is used, the first control valve 7 is firstly in the first state, at the moment, the injection pump is communicated with the first container 8, the injection pump provides negative pressure, after cleaning liquid in the first container 8 is extracted, the first control valve 7 is switched to the second state, the injection pump is communicated with the interface 2 on the side wall of the cleaning pool 1, and the injection pump provides positive pressure to push the cleaning liquid to enter the cleaning pool 1 through the interface 2 on the side wall of the cleaning pool 1.
For this reason, in the embodiment of the present invention, the sampling needle inner wall cleaning module includes a second pressure source 12 capable of providing positive pressure and negative pressure, as shown in fig. 1, the second pressure source 12 is also a syringe pump, as the same as the first pressure source 10, the end of the sampling needle 3 away from the needle tip is communicated with the second pressure source 12, and the second pressure source 12 drives the cleaning solution to move back and forth through the positive pressure and the negative pressure.
Because the sampling needle cleaning device provided by the embodiment of the invention mainly aims at cleaning proteins with strong adhesive force, the cleaning liquid in the first container 8 is hemolytic agent, namely the cleaning liquid used in the process of cleaning the needle point and the inner wall is hemolytic agent, and the hemolytic agent has stronger dissolving capacity for the proteins and better cleaning effect compared with the diluent in the prior art, but the hemolytic agent can interfere with the next sampling, so that after the hemolytic agent is used for cleaning, in order to avoid the hemolytic agent remaining on the inner wall of the sampling needle 3, the diluent is used for cleaning the inner wall of the sampling needle 3 again.
In order to achieve the above purpose, the sampling needle inner wall cleaning module further includes a second control valve 5 and a second container 9, one end of the sampling needle 3 away from the needle tip is communicated with a second pressure source 12 through the second control valve 5, the second container 9 is communicated with the second control valve 5, the second control valve 5 can communicate the second container 9 with the second pressure source 12 in a first state, and the second control valve 5 can communicate the second pressure source 12 with one end of the sampling needle 3 away from the needle tip in a second state, in the embodiment of the present invention, the cleaning solution contained in the second container 9 is a diluent; after the needle tip cleaning module finishes cleaning the needle tip, the second control valve 5 is in a second state, the second pressure source 12 is communicated with the sampling needle 3, the second pressure source 12 provides negative pressure to extract cleaning liquid in the cleaning pool 1, then provides positive pressure to push back the extracted cleaning liquid, and the reciprocating cleaning of the inner wall of the sampling needle 3 is realized in such a reciprocating way; then the second control valve 5 is switched to the first state, the second pressure source 12 is communicated with the second container 9, the second pressure source 12 draws the diluent from the second container 9, then the second control valve 5 is switched to the second state, the second pressure source 12 is communicated with the sampling needle 3, and the second pressure source 12 pushes the diluent out of the sampling needle 3 to perform secondary cleaning on the inner wall of the sampling needle 3 so as to remove the residual hemolytic agent.
In the embodiment of the present invention, as shown in fig. 1, the sampling needle cleaning device further includes a sampling needle outer wall cleaning module, the sampling needle outer wall cleaning module includes a swab 4 and a cleaning liquid delivery device, the sampling needle 3 extends out from an inner cavity of the swab 4, the swab 4 is provided with an inlet communicated with the inner cavity of the sampling needle, the cleaning liquid delivery device is communicated with the inlet of the swab 4, and the outer wall of the sampling needle 3 is cleaned by moving the sampling needle 3 or the swab 4 up and down.
In the embodiment of the present invention, the cleaning solution supplied to the swab 4 by the cleaning solution delivery device is a diluent, and therefore, as shown in fig. 1, the cleaning solution delivery device includes a third pressure source 11, and the third pressure source 11 connects the second container 9 with the inlet of the swab 4, although other liquid supplying methods may be adopted, such as first performing a first cleaning on the outer wall of the sampling needle 3 by using a hemolytic agent, and then performing a second cleaning on the outer wall of the sampling needle 3 by using the diluent.
To further optimize the above solution, as shown in fig. 1, the third pressure source 11 is also a syringe pump, and therefore the rinsing liquid delivery device further comprises a third control valve 6, the third control valve 6 communicating the third pressure source 11 with the second container 9 in the first state and lowering the third pressure source 11 into communication with the inlet of the swab 4 in the second state.
In the embodiment of the present invention, the first control valve 7, the second control valve 5, and the third control valve 6 are all two-position three-way solenoid valves.
The cleaning liquid used on the swab 4 can directly flow into the cleaning pool 1 along the sampling needle 3, and also can be recovered to guide the cleaning liquid to be discharged, as shown in fig. 1, an outlet is further arranged on the swab 4, and the outlet of the swab 4 is communicated with the waste liquid conveying device, so that the used cleaning liquid is sucked away and discharged by the waste liquid conveying device along with the cleaning of the outer wall of the sampling needle 3 by the swab 4.
Further, wash 1 bottoms in pond and be provided with the export, wash the export and the waste liquid conveyor intercommunication in pond 1.
As shown in FIG. 1, in the embodiment of the present invention, the waste liquid delivery device comprises a waste liquid pump 15 and two branches, one branch is communicated with the outlet of the swab 4 through a fourth control valve 13, and the other branch is communicated with the outlet at the bottom of the cleaning pool 1 through a fifth control valve 14, and during the use process, the fourth control valve 13 or the fifth control valve 14 can be opened according to the cleaning process to discharge the waste liquid in time.
In the sampling needle cleaning device provided by the invention, the sampling needle 3 needs to be moved to different positions in different cleaning stages, for example, the sampling needle 3 needs to be extended downwards into the cleaning pool 1 to clean the needle point, and after the inner wall is cleaned, the sampling needle 3 needs to be lifted into the swab 4 to clean the outer wall, so that in the embodiment of the invention, the sampling needle cleaning device can also comprise a sampling needle 3 moving device to move the sampling needle 3 in the X direction, the Y direction and the Z direction, and certainly, if the blood cell analyzer has the function of moving the sampling needle 3, the function can also be directly used for realizing the movement of the sampling needle 3.
An embodiment of the present invention further provides a sampling needle cleaning method based on the sampling needle cleaning device, please refer to fig. 3, where fig. 3 is a flowchart of the sampling needle cleaning method according to the embodiment of the present invention, and the method includes the steps of:
s1: a sampling needle 3 is extended into a cleaning pool 1, and the needle tip of the sampling needle is positioned below the connection part of a port 2 on the side wall of the cleaning pool 1 and the cleaning pool 1;
in the process, the depth of the sampling needle 3 extending into the cleaning pool 1 is preferably controlled to ensure that the needle tip is axially connected with the interface 2 on the side wall of the cleaning pool 1 at one point, so that the cleaning liquid directly impacts the needle tip of the sampling needle 3 when flowing into the cleaning pool 1.
S2: introducing a first cleaning solution into the cleaning pool 1 to wash the needle tip of the sampling needle 3;
when the first cleaning solution is introduced, the first cleaning solution should have a certain flow rate to impact the needle tip of the sampling needle 3, so as to improve the cleaning effect.
S3: extracting a first cleaning liquid and driving the first cleaning liquid to move back and forth to clean the inner wall of the sampling needle 3 back and forth;
the first cleaning liquid used in the above steps may be the first cleaning liquid accumulated in the cleaning pool 1 after cleaning the needle point, or may be extracted from another place, and as with the needle point cleaning, the first cleaning liquid for cleaning the inner wall must have a certain flow rate to impact the attached matter on the inner wall.
Since the needle tip has a small volume and a small amount of residual sample, the first cleaning solution after the needle tip is cleaned can be used continuously, in the embodiment of the present invention, the first cleaning solution extracted in step S3 is the first cleaning solution stored in the cleaning pool 1 after step S2 is completed, and step S3 is specifically to immerse the needle tip of the sampling needle 3 in the first cleaning solution in the cleaning pool 1, and extract the first cleaning solution in the cleaning pool 1 to perform reciprocating cleaning on the inner wall of the sampling needle 3.
Of course, in other embodiments, the inner wall of the sampling needle 3 may be cleaned with a completely new unused cleaning solution.
Further, the method for cleaning the sampling needle further comprises the following steps:
s4: extracting a second cleaning liquid to clean the inner wall of the sampling needle 3 so as to remove the residual first cleaning liquid;
in the embodiment of the present invention, the second cleaning liquid is a diluent to remove the remaining first cleaning liquid, so as to avoid the adverse effect of the first cleaning liquid on the next sampling, and when the second cleaning liquid is used to clean the inner wall of the sampling needle 3, the sampling needle 3 must be lifted off the first cleaning liquid in the cleaning pool 1 first, or the first cleaning liquid in the cleaning pool 1 must be emptied first.
In order to better remove protein, in the embodiment of the present invention, two kinds of washing solutions are used in combination, wherein the first washing solution is a hemolytic agent, and the second washing solution is a diluent, but in practical applications, only one kind of washing solution may be used to wash the sampling needle, that is, the first washing solution and the second washing solution are the same, in this case, the above-mentioned method for washing the sampling needle skips step S4, and proceeds from step S3 to step S5 directly.
After the four steps are completed, the inner wall and the needle tip of the sampling needle 3 are cleaned, and then the outer wall of the sampling needle 3 is cleaned, as shown in fig. 3, the method for cleaning the sampling needle further comprises the following steps:
s5: the sampling needle 3 is lifted into the swab 4 and separated from the cleaning liquid in the cleaning pool 1, and a second cleaning liquid is introduced into the swab 4 to clean the outer wall of the sampling needle 3;
in the embodiment of the present invention, the second cleaning solution, i.e., the diluent, is directly used to clean the outer wall of the sampling needle 3, and in other embodiments, the first cleaning solution may be used to clean first and then the second cleaning solution is used to perform a secondary cleaning.
S6: the waste liquid in the washing tank 1 is emptied.
Further optimizing the above technical solution, in the embodiment of the present invention, in step S5, the second cleaning solution is introduced into the swab 4 to clean the outer wall of the sampling needle 3, and the second cleaning solution having washed the outer wall of the sampling needle 3 in the swab 4 is removed.
The above embodiment is performed according to the sequence of the sampling needle tip → the inner wall of the sampling needle → the outer wall of the sampling needle, but this is only a preferred embodiment provided by the present invention, and the sequence is not limited thereto, and the sequence may be broken, and the cleaning may be performed according to the sequence of the inner wall of the sampling needle → the tip of the sampling needle → the outer wall of the sampling needle, or according to any sequence, which is not limited herein.
As described above, the embodiment of the present invention provides a sampling needle cleaning device and a sampling needle cleaning method based on the sampling needle cleaning device, the device has a simple structure and is convenient to operate, the device combination method can fully and effectively clean the needle point and the inner wall of the sampling needle 3, and the inner and outer sides and the needle point of the sampling needle 3 can be fully cleaned by matching with the outer wall cleaning device, so as to avoid carrying pollution.
The embodiments in the present description are described in a progressive manner, each embodiment focuses on differences from other embodiments, and the same and similar parts among the embodiments are referred to each other.
The previous description of the disclosed embodiments is provided to enable any person skilled in the art to make or use the present invention. Various modifications to these embodiments will be readily apparent to those skilled in the art, and the generic principles defined herein may be applied to other embodiments without departing from the spirit or scope of the invention. Thus, the present invention is not intended to be limited to the embodiments shown herein but is to be accorded the widest scope consistent with the principles and novel features disclosed herein.
Claims (10)
1. A sampling needle cleaning device, comprising:
a cleaning tank;
the needle point cleaning module is communicated with an interface on the side wall of the cleaning pool and used for conveying cleaning liquid to the cleaning pool to clean the needle point of the sampling needle, the needle point cleaning module comprises a first pressure source and a first container for containing the cleaning liquid, the first pressure source extracts the cleaning liquid from the first container and sends the cleaning liquid to the cleaning pool, the first pressure source is an injection pump, the needle point cleaning module further comprises a first control valve, the first container, the first pressure source and the interface on the side wall of the cleaning pool are all communicated with the first control valve, the first container can be communicated with the first pressure source by the first control valve in a first state, and the first pressure source can be communicated with the interface on the side wall of the cleaning pool by the first control valve in a second state;
the sampling needle inner wall cleaning module is communicated with the sampling needle and used for driving cleaning liquid to carry out reciprocating cleaning on the inner wall of the sampling needle, the sampling needle inner wall cleaning module comprises a second pressure source, one end of the sampling needle far away from the needle point is communicated with the second pressure source, the second pressure source can provide positive pressure and negative pressure to drive the cleaning liquid to move in a reciprocating manner, the sampling needle inner wall cleaning module further comprises a second control valve and a second container, one end of the sampling needle far away from the needle tip is communicated with the second pressure source through the second control valve, the second reservoir being in communication with the second control valve, the second control valve being capable of communicating the second reservoir with the second pressure source in a first state, the second control valve is capable of communicating the second pressure source with an end of the sampling needle distal from the needle tip in a second state.
2. The sampling needle cleaning device according to claim 1, wherein the cross section of the cleaning pool is circular, and the interface on the side wall of the cleaning pool is communicated with the cleaning pool along the tangential direction of the cleaning pool.
3. The sampling needle cleaning device of claim 2, wherein the port on the side wall of the cleaning basin is sloped downward.
4. The sampling needle cleaning device according to any one of claims 1 to 3, further comprising a sampling needle outer wall cleaning module, wherein the sampling needle outer wall cleaning module comprises a swab and a cleaning solution delivery device, the sampling needle extends from the inner cavity of the swab, an inlet communicated with the inner cavity is formed in the swab, and the cleaning solution delivery device is communicated with the inlet of the swab.
5. The sampling needle cleaning device according to claim 4, wherein an outlet is provided at the bottom of the cleaning pool, and the outlet of the cleaning pool is communicated with a waste liquid conveying device.
6. A sampling needle cleaning method based on the sampling needle cleaning device according to any one of claims 1 to 5, characterized by comprising the steps of:
1) the sampling needle is extended into the cleaning pool, and the needle point of the sampling needle is positioned below the communication position of the interface on the side wall of the cleaning pool and the cleaning pool;
2) introducing a first cleaning solution into the cleaning pool to wash the needle tip of the sampling needle;
3) extracting a first cleaning liquid and driving the first cleaning liquid to move in a reciprocating manner so as to clean the inner wall of the sampling needle in a reciprocating manner;
the first cleaning liquid extracted in the step 3) is the first cleaning liquid stored in the cleaning pool after the step 2) is completed, and the step 3) is to immerse the needle point of the sampling needle in the first cleaning liquid in the cleaning pool and extract the first cleaning liquid in the cleaning pool to perform reciprocating cleaning on the inner wall of the sampling needle.
7. The method of cleaning a sampling needle of claim 6, further comprising the steps of:
4) and extracting the second cleaning liquid to clean the inner wall of the sampling needle so as to remove the residual first cleaning liquid.
8. The method of cleaning a sampling needle of claim 7, further comprising the steps of:
5) lifting the sampling needle into the swab and separating the sampling needle from the cleaning liquid in the cleaning pool, and introducing a second cleaning liquid into the swab to clean the outer wall of the sampling needle;
6) and emptying the waste liquid in the cleaning pool.
9. The method for cleaning a sampling needle according to claim 8, wherein if the first cleaning liquid is the same as the second cleaning liquid, the step 3) is directly performed to the step 5).
10. The method for washing a sampling needle according to any one of claims 7 to 9, wherein the first washing solution is a hemolytic agent and the second washing solution is a diluent.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810411541.1A CN110434128B (en) | 2018-05-02 | 2018-05-02 | Sampling needle cleaning device and cleaning method |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810411541.1A CN110434128B (en) | 2018-05-02 | 2018-05-02 | Sampling needle cleaning device and cleaning method |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN110434128A CN110434128A (en) | 2019-11-12 |
| CN110434128B true CN110434128B (en) | 2021-10-29 |
Family
ID=68426969
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201810411541.1A Active CN110434128B (en) | 2018-05-02 | 2018-05-02 | Sampling needle cleaning device and cleaning method |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN110434128B (en) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112858659B (en) * | 2019-11-28 | 2022-10-28 | 深圳市帝迈生物技术有限公司 | Sampling needle cleaning system, sample analyzer and immune luminescence analyzer |
| CN112858660A (en) * | 2019-11-28 | 2021-05-28 | 深圳市帝迈生物技术有限公司 | Magnetic separation cleaning system and imbibition needle subassembly, immunoassay appearance thereof |
| CN113311163B (en) * | 2020-02-26 | 2024-04-12 | 深圳迈瑞生物医疗电子股份有限公司 | Cleaning method of detection pool |
| CN114308849B (en) * | 2020-09-29 | 2023-04-18 | 深圳市帝迈生物技术有限公司 | Method for avoiding liquid level error detection and sample analyzer |
| CN114643241B (en) * | 2020-12-18 | 2023-12-01 | 深圳市帝迈生物技术有限公司 | Liquid supply system and liquid supply method |
| CN114082455B (en) * | 2021-10-21 | 2023-01-06 | 华南理工大学 | Recyclable hollow cantilever probe front end loading and cleaning method |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2606885B1 (en) * | 1986-11-14 | 1989-08-04 | Abx Sarl | DEVICE FOR CLEANING A LIQUID COLLECTION NEEDLE |
| CN101869894B (en) * | 2009-04-24 | 2016-11-09 | 深圳迈瑞生物医疗电子股份有限公司 | Clean device, purging system, cleaning method and particle analyzer |
| CN104107815B (en) * | 2013-04-16 | 2017-11-07 | 深圳迈瑞生物医疗电子股份有限公司 | Cleaning device, method and the device for analyzing samples of sampling needle |
| CN111530854B (en) * | 2014-10-16 | 2021-09-28 | 北京普利生仪器有限公司 | Sampling needle cleaning system and sampling needle cleaning method |
-
2018
- 2018-05-02 CN CN201810411541.1A patent/CN110434128B/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| CN110434128A (en) | 2019-11-12 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN110434128B (en) | Sampling needle cleaning device and cleaning method | |
| CN208636331U (en) | Sampling needle cleaning device | |
| CN101960315A (en) | Cleaning liquid is handled the apparatus and method of probe | |
| US7939017B2 (en) | Automated fluid handling system and method | |
| CN106199032B (en) | A kind of sample injection method of no cross contamination | |
| CN101869894B (en) | Clean device, purging system, cleaning method and particle analyzer | |
| CN1310980A (en) | Method and equipment for treating various kinds of liquid | |
| JPH09274048A (en) | Pretreatment apparatus | |
| CN105562389A (en) | Sampling needle cleaning system and sampling needle cleaning method | |
| CN112858659B (en) | Sampling needle cleaning system, sample analyzer and immune luminescence analyzer | |
| CN207036844U (en) | Sample analyser | |
| CN201974434U (en) | Automation device for fast cleaning sample needles | |
| CN201965136U (en) | Flow path system for automation biochemical reaction flow | |
| JPH04105065A (en) | Cup washing device | |
| CN111570422A (en) | Sampling needle cleaning device and method | |
| CN116037588A (en) | Classification pool cleaning system, method and analyzer | |
| JP4500081B2 (en) | Nozzle cleaning method and nozzle cleaning device | |
| JP2577350B2 (en) | Cleaning method in automatic chemical analyzer | |
| CN219130198U (en) | Liquid device for removing outer wall of sampling needle of glycosylated hemoglobin instrument | |
| CN109427620A (en) | Pump installation, processing liquid supplying device, substrate board treatment, fluid-discharge method and liquid displacement method | |
| CN210322524U (en) | A suction filtration extraction element for grain fatty acid value survey | |
| JP3752653B2 (en) | Sample dilution method and apparatus | |
| CN212442398U (en) | Needle tube cleaning pool | |
| JP3965043B2 (en) | Nozzle cleaning device | |
| CN205587387U (en) | Automatic dual belt cleaning device of liquid that annotates of test tube |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| GR01 | Patent grant | ||
| GR01 | Patent grant |