CN116217603A - 新化合物 - Google Patents

新化合物 Download PDF

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Publication number
CN116217603A
CN116217603A CN202310268678.7A CN202310268678A CN116217603A CN 116217603 A CN116217603 A CN 116217603A CN 202310268678 A CN202310268678 A CN 202310268678A CN 116217603 A CN116217603 A CN 116217603A
Authority
CN
China
Prior art keywords
compound
benzo
hydroxy
dihydro
pyridin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN202310268678.7A
Other languages
English (en)
Chinese (zh)
Inventor
J·利德勒
A·L·沃克
G·V·怀特
A·德尼
N·多迪克
M-H·福歇
A·布里约
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Institut National de la Sante et de la Recherche Medicale INSERM
Original Assignee
Institut National de la Sante et de la Recherche Medicale INSERM
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Institut National de la Sante et de la Recherche Medicale INSERM filed Critical Institut National de la Sante et de la Recherche Medicale INSERM
Publication of CN116217603A publication Critical patent/CN116217603A/zh
Pending legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/69—Boron compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/04—Antipruritics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
    • C07F5/02—Boron compounds
    • C07F5/025—Boronic and borinic acid compounds

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Dermatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CN202310268678.7A 2018-06-07 2019-06-05 新化合物 Pending CN116217603A (zh)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GBGB1809378.1A GB201809378D0 (en) 2018-06-07 2018-06-07 Novel compounds
GB1809378.1 2018-06-07
CN201980037789.9A CN112236433B (zh) 2018-06-07 2019-06-05 新化合物
PCT/EP2019/064599 WO2019234075A1 (en) 2018-06-07 2019-06-05 Novel benzimidamides compounds comprising an oxaborinin ring

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
CN201980037789.9A Division CN112236433B (zh) 2018-06-07 2019-06-05 新化合物

Publications (1)

Publication Number Publication Date
CN116217603A true CN116217603A (zh) 2023-06-06

Family

ID=62975712

Family Applications (2)

Application Number Title Priority Date Filing Date
CN202310268678.7A Pending CN116217603A (zh) 2018-06-07 2019-06-05 新化合物
CN201980037789.9A Active CN112236433B (zh) 2018-06-07 2019-06-05 新化合物

Family Applications After (1)

Application Number Title Priority Date Filing Date
CN201980037789.9A Active CN112236433B (zh) 2018-06-07 2019-06-05 新化合物

Country Status (9)

Country Link
US (2) US11352372B2 (https=)
EP (1) EP3802550B1 (https=)
JP (1) JP7317866B2 (https=)
KR (1) KR102661802B1 (https=)
CN (2) CN116217603A (https=)
BR (1) BR112020024740A2 (https=)
ES (1) ES2973710T3 (https=)
GB (1) GB201809378D0 (https=)
WO (1) WO2019234075A1 (https=)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20200040103A1 (en) 2018-03-14 2020-02-06 Genentech, Inc. Anti-klk5 antibodies and methods of use
GB201809378D0 (en) * 2018-06-07 2018-07-25 Glaxosmithkline Ip Dev Ltd Novel compounds
PH12022550646A1 (en) 2019-09-18 2023-04-03 Genentech Inc Anti-klk7 antibodies, anti-klk5 antibodies, multispecific anti-klk5/klk7 antibodies, and methods of use

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101160124A (zh) * 2005-02-16 2008-04-09 安纳考尔医药公司 含硼的小分子
CN102014927A (zh) * 2008-03-06 2011-04-13 安纳考尔医药公司 作为抗炎药的含硼的小分子
CN106132940A (zh) * 2014-01-23 2016-11-16 西可斯拉制药公司 新的激肽释放酶7 抑制剂
CN112236433B (zh) * 2018-06-07 2023-04-04 国家医疗保健研究所 新化合物

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HRP20160569T1 (hr) 2007-12-03 2016-07-29 Obe Therapy Biotechnology Boropeptidni inhibitori enteropeptidaze i njihove uporabe u liječenju pretilosti, pretjerane tjelesne težine i/ili bolesti povezane s abnormalnim metabolizmom masti
SI3097085T1 (sl) 2014-01-23 2020-11-30 Sixera Pharma Ab Derivati benzoksazinona za zdravljenje kožnih bolezni

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101160124A (zh) * 2005-02-16 2008-04-09 安纳考尔医药公司 含硼的小分子
CN102014927A (zh) * 2008-03-06 2011-04-13 安纳考尔医药公司 作为抗炎药的含硼的小分子
CN106132940A (zh) * 2014-01-23 2016-11-16 西可斯拉制药公司 新的激肽释放酶7 抑制剂
CN112236433B (zh) * 2018-06-07 2023-04-04 国家医疗保健研究所 新化合物

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
NICOLAS MASURIER等: ""Inhibitors of kallikrein-related peptidases:An overview"", 《MED RES REV》, vol. 38, 13 June 2017 (2017-06-13), pages 655 - 683, XP002793161, DOI: 10.1002/med.21451 *

Also Published As

Publication number Publication date
EP3802550B1 (en) 2023-12-27
ES2973710T3 (es) 2024-06-24
CN112236433A (zh) 2021-01-15
EP3802550A1 (en) 2021-04-14
US11767333B2 (en) 2023-09-26
US20210253604A1 (en) 2021-08-19
BR112020024740A2 (pt) 2021-03-23
JP7317866B2 (ja) 2023-07-31
GB201809378D0 (en) 2018-07-25
JP2021530440A (ja) 2021-11-11
KR20210018464A (ko) 2021-02-17
WO2019234075A1 (en) 2019-12-12
US11352372B2 (en) 2022-06-07
KR102661802B1 (ko) 2024-04-26
CN112236433B (zh) 2023-04-04
US20220267357A1 (en) 2022-08-25

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Application publication date: 20230606