KR102661802B1 - 옥사보리닌 환을 포함하는 신규한 벤즈이미드아미드 화합물 - Google Patents

옥사보리닌 환을 포함하는 신규한 벤즈이미드아미드 화합물 Download PDF

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KR102661802B1
KR102661802B1 KR1020217000497A KR20217000497A KR102661802B1 KR 102661802 B1 KR102661802 B1 KR 102661802B1 KR 1020217000497 A KR1020217000497 A KR 1020217000497A KR 20217000497 A KR20217000497 A KR 20217000497A KR 102661802 B1 KR102661802 B1 KR 102661802B1
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South Korea
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compound
compounds
trifluoromethyl
benzo
dihydro
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KR1020217000497A
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Korean (ko)
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KR20210018464A (ko
Inventor
존 리들
앤 루이스 워커
젬마 빅토리아 화이트
알렉시스 드니스
마리-엘렌 푸셰
안느 부이욧
네리나 도딕
Original Assignee
인스티튜트 내셔널 드 라 싼테 에 드 라 리셰르셰 메디칼르 (인 썸)
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
    • C07F5/02—Boron compounds
    • C07F5/025—Boronic and borinic acid compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/69—Boron compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/04—Antipruritics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Dermatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
KR1020217000497A 2018-06-07 2019-06-05 옥사보리닌 환을 포함하는 신규한 벤즈이미드아미드 화합물 Active KR102661802B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB1809378.1A GB201809378D0 (en) 2018-06-07 2018-06-07 Novel compounds
GB1809378.1 2018-06-07
PCT/EP2019/064599 WO2019234075A1 (en) 2018-06-07 2019-06-05 Novel benzimidamides compounds comprising an oxaborinin ring

Publications (2)

Publication Number Publication Date
KR20210018464A KR20210018464A (ko) 2021-02-17
KR102661802B1 true KR102661802B1 (ko) 2024-04-26

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Application Number Title Priority Date Filing Date
KR1020217000497A Active KR102661802B1 (ko) 2018-06-07 2019-06-05 옥사보리닌 환을 포함하는 신규한 벤즈이미드아미드 화합물

Country Status (9)

Country Link
US (2) US11352372B2 (https=)
EP (1) EP3802550B1 (https=)
JP (1) JP7317866B2 (https=)
KR (1) KR102661802B1 (https=)
CN (2) CN112236433B (https=)
BR (1) BR112020024740A2 (https=)
ES (1) ES2973710T3 (https=)
GB (1) GB201809378D0 (https=)
WO (1) WO2019234075A1 (https=)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20200040103A1 (en) 2018-03-14 2020-02-06 Genentech, Inc. Anti-klk5 antibodies and methods of use
GB201809378D0 (en) * 2018-06-07 2018-07-25 Glaxosmithkline Ip Dev Ltd Novel compounds
PE20221906A1 (es) 2019-09-18 2022-12-23 Genentech Inc Anticuerpos anti-klk7, anticuerpos anti-klk5, anticuerpos multiespecificos anti-klk5/klk7 y metodos de uso

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006089067A2 (en) 2005-02-16 2006-08-24 Anacor Pharmaceuticals, Inc. Boron-containing small molecules
WO2015112079A1 (en) 2014-01-23 2015-07-30 Sixera Pharma Ab New kallikrein 7 inhibitors

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2575131T3 (es) 2007-12-03 2016-06-24 Obe Therapy Biotechnology Inhibidores boropéptidos de enteropeptidasa y sus usos en tratamientos de obesidad, sobrepeso y/o enfermedades asociadas con un metabolismo anormal de la grasa
CN102014927A (zh) * 2008-03-06 2011-04-13 安纳考尔医药公司 作为抗炎药的含硼的小分子
DK3097085T3 (da) 2014-01-23 2020-10-26 Sixera Pharma Ab Benzoxazinonderivater til behandling af hudsygdomme
GB201809378D0 (en) * 2018-06-07 2018-07-25 Glaxosmithkline Ip Dev Ltd Novel compounds

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006089067A2 (en) 2005-02-16 2006-08-24 Anacor Pharmaceuticals, Inc. Boron-containing small molecules
WO2015112079A1 (en) 2014-01-23 2015-07-30 Sixera Pharma Ab New kallikrein 7 inhibitors

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
Medicinal Research Reviews, Vol.38, pp.655-683, 2018

Also Published As

Publication number Publication date
BR112020024740A2 (pt) 2021-03-23
WO2019234075A1 (en) 2019-12-12
US20220267357A1 (en) 2022-08-25
JP7317866B2 (ja) 2023-07-31
US11767333B2 (en) 2023-09-26
EP3802550A1 (en) 2021-04-14
GB201809378D0 (en) 2018-07-25
CN112236433B (zh) 2023-04-04
US20210253604A1 (en) 2021-08-19
JP2021530440A (ja) 2021-11-11
CN116217603A (zh) 2023-06-06
US11352372B2 (en) 2022-06-07
KR20210018464A (ko) 2021-02-17
ES2973710T3 (es) 2024-06-24
EP3802550B1 (en) 2023-12-27
CN112236433A (zh) 2021-01-15

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