CN116196486A - 用于制造支架的生物可降解复合材料组合物及其制备方法 - Google Patents
用于制造支架的生物可降解复合材料组合物及其制备方法 Download PDFInfo
- Publication number
- CN116196486A CN116196486A CN202211431683.7A CN202211431683A CN116196486A CN 116196486 A CN116196486 A CN 116196486A CN 202211431683 A CN202211431683 A CN 202211431683A CN 116196486 A CN116196486 A CN 116196486A
- Authority
- CN
- China
- Prior art keywords
- poly
- lactide
- biodegradable composite
- trimethylene carbonate
- polylactic acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000000203 mixture Substances 0.000 title claims abstract description 37
- 239000002131 composite material Substances 0.000 title claims abstract description 36
- 238000004519 manufacturing process Methods 0.000 title claims abstract description 28
- 238000002360 preparation method Methods 0.000 title abstract description 8
- 238000000034 method Methods 0.000 claims abstract description 16
- 229920000747 poly(lactic acid) Polymers 0.000 claims description 37
- 239000004626 polylactic acid Substances 0.000 claims description 37
- HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 claims description 22
- 238000001035 drying Methods 0.000 claims description 15
- 239000002245 particle Substances 0.000 claims description 7
- 238000002156 mixing Methods 0.000 claims description 6
- 238000010298 pulverizing process Methods 0.000 claims description 5
- 238000004090 dissolution Methods 0.000 claims description 2
- 230000000704 physical effect Effects 0.000 abstract description 5
- 229920006167 biodegradable resin Polymers 0.000 abstract description 4
- 238000003980 solgel method Methods 0.000 abstract description 2
- 239000000126 substance Substances 0.000 abstract description 2
- 229920001432 poly(L-lactide) Polymers 0.000 description 15
- JVTAAEKCZFNVCJ-REOHCLBHSA-N L-lactic acid Chemical compound C[C@H](O)C(O)=O JVTAAEKCZFNVCJ-REOHCLBHSA-N 0.000 description 11
- 229920005989 resin Polymers 0.000 description 10
- 239000011347 resin Substances 0.000 description 10
- 210000004204 blood vessel Anatomy 0.000 description 8
- 239000002994 raw material Substances 0.000 description 7
- 230000000052 comparative effect Effects 0.000 description 6
- 239000000463 material Substances 0.000 description 5
- 238000012545 processing Methods 0.000 description 5
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 4
- 239000000654 additive Substances 0.000 description 3
- 230000002526 effect on cardiovascular system Effects 0.000 description 3
- 230000000694 effects Effects 0.000 description 3
- 238000001125 extrusion Methods 0.000 description 3
- 238000012986 modification Methods 0.000 description 3
- 230000004048 modification Effects 0.000 description 3
- 239000004800 polyvinyl chloride Substances 0.000 description 3
- 229920000915 polyvinyl chloride Polymers 0.000 description 3
- 239000004952 Polyamide Substances 0.000 description 2
- 239000004698 Polyethylene Substances 0.000 description 2
- 230000017531 blood circulation Effects 0.000 description 2
- 238000006243 chemical reaction Methods 0.000 description 2
- 239000011248 coating agent Substances 0.000 description 2
- 230000007797 corrosion Effects 0.000 description 2
- 238000005260 corrosion Methods 0.000 description 2
- 201000010099 disease Diseases 0.000 description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
- 239000003814 drug Substances 0.000 description 2
- 229940079593 drug Drugs 0.000 description 2
- 238000002474 experimental method Methods 0.000 description 2
- JJTUDXZGHPGLLC-UHFFFAOYSA-N lactide Chemical compound CC1OC(=O)C(C)OC1=O JJTUDXZGHPGLLC-UHFFFAOYSA-N 0.000 description 2
- 239000012567 medical material Substances 0.000 description 2
- 239000002184 metal Substances 0.000 description 2
- 239000007769 metal material Substances 0.000 description 2
- 229920002647 polyamide Polymers 0.000 description 2
- 229920000573 polyethylene Polymers 0.000 description 2
- -1 polyethylene terephthalate Polymers 0.000 description 2
- 229920000139 polyethylene terephthalate Polymers 0.000 description 2
- 239000005020 polyethylene terephthalate Substances 0.000 description 2
- 229920000642 polymer Polymers 0.000 description 2
- 238000012360 testing method Methods 0.000 description 2
- 230000002792 vascular Effects 0.000 description 2
- KVZLHPXEUGJPAH-UHFFFAOYSA-N 2-oxidanylpropanoic acid Chemical compound CC(O)C(O)=O.CC(O)C(O)=O KVZLHPXEUGJPAH-UHFFFAOYSA-N 0.000 description 1
- JVTAAEKCZFNVCJ-UWTATZPHSA-N D-lactic acid Chemical compound C[C@@H](O)C(O)=O JVTAAEKCZFNVCJ-UWTATZPHSA-N 0.000 description 1
- 241000196324 Embryophyta Species 0.000 description 1
- 229920001244 Poly(D,L-lactide) Polymers 0.000 description 1
- 244000061456 Solanum tuberosum Species 0.000 description 1
- 235000002595 Solanum tuberosum Nutrition 0.000 description 1
- 208000007536 Thrombosis Diseases 0.000 description 1
- 240000008042 Zea mays Species 0.000 description 1
- 235000005824 Zea mays ssp. parviglumis Nutrition 0.000 description 1
- 235000002017 Zea mays subsp mays Nutrition 0.000 description 1
- 230000000996 additive effect Effects 0.000 description 1
- 239000003963 antioxidant agent Substances 0.000 description 1
- 229920000704 biodegradable plastic Polymers 0.000 description 1
- 229920002988 biodegradable polymer Polymers 0.000 description 1
- 239000004621 biodegradable polymer Substances 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 230000002490 cerebral effect Effects 0.000 description 1
- 238000000576 coating method Methods 0.000 description 1
- 229920001577 copolymer Polymers 0.000 description 1
- 238000007334 copolymerization reaction Methods 0.000 description 1
- 235000005822 corn Nutrition 0.000 description 1
- 210000004351 coronary vessel Anatomy 0.000 description 1
- 229940022769 d- lactic acid Drugs 0.000 description 1
- 230000000916 dilatatory effect Effects 0.000 description 1
- 230000010339 dilation Effects 0.000 description 1
- 238000006073 displacement reaction Methods 0.000 description 1
- 239000003527 fibrinolytic agent Substances 0.000 description 1
- 239000007943 implant Substances 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 238000003780 insertion Methods 0.000 description 1
- 230000037431 insertion Effects 0.000 description 1
- 238000011835 investigation Methods 0.000 description 1
- 238000000465 moulding Methods 0.000 description 1
- 239000002667 nucleating agent Substances 0.000 description 1
- 239000005022 packaging material Substances 0.000 description 1
- 238000004806 packaging method and process Methods 0.000 description 1
- 229920003023 plastic Polymers 0.000 description 1
- 239000004033 plastic Substances 0.000 description 1
- 239000002985 plastic film Substances 0.000 description 1
- 239000004014 plasticizer Substances 0.000 description 1
- 238000006068 polycondensation reaction Methods 0.000 description 1
- 229920000728 polyester Polymers 0.000 description 1
- 239000011342 resin composition Substances 0.000 description 1
- 208000037803 restenosis Diseases 0.000 description 1
- 238000007151 ring opening polymerisation reaction Methods 0.000 description 1
- 239000003381 stabilizer Substances 0.000 description 1
- 238000004381 surface treatment Methods 0.000 description 1
- 238000005979 thermal decomposition reaction Methods 0.000 description 1
- YFHICDDUDORKJB-UHFFFAOYSA-N trimethylene carbonate Chemical compound O=C1OCCCO1 YFHICDDUDORKJB-UHFFFAOYSA-N 0.000 description 1
- 238000001291 vacuum drying Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/04—Macromolecular materials
- A61L31/06—Macromolecular materials obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/04—Macromolecular materials
- A61L31/041—Mixtures of macromolecular compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L31/148—Materials at least partially resorbable by the body
Landscapes
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- Vascular Medicine (AREA)
- Epidemiology (AREA)
- Surgery (AREA)
- Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Materials For Medical Uses (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Cardiology (AREA)
- Transplantation (AREA)
- Oral & Maxillofacial Surgery (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| KR10-2021-0169090 | 2021-11-30 | ||
| KR1020210169090A KR102407468B1 (ko) | 2021-11-30 | 2021-11-30 | 스텐트 제조용 생분해성 복합소재 조성물 및 이의 제조 방법 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN116196486A true CN116196486A (zh) | 2023-06-02 |
Family
ID=81986234
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202211431683.7A Pending CN116196486A (zh) | 2021-11-30 | 2022-11-16 | 用于制造支架的生物可降解复合材料组合物及其制备方法 |
Country Status (3)
| Country | Link |
|---|---|
| KR (1) | KR102407468B1 (fr) |
| CN (1) | CN116196486A (fr) |
| CA (1) | CA3182829A1 (fr) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR102549190B1 (ko) * | 2022-12-30 | 2023-07-06 | 주식회사 파인트코리아 | 말초혈관 스텐트 제조용 생분해성 복합소재 조성물 및 이의 제조방법 |
Citations (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5320624A (en) * | 1991-02-12 | 1994-06-14 | United States Surgical Corporation | Blends of glycolide and/or lactide polymers and caprolactone and/or trimethylene carbonate polymers and absorbable surgical devices made therefrom |
| KR20070063511A (ko) * | 2004-08-13 | 2007-06-19 | 세타곤 인코포레이티드 | 나노 다공성 층을 구비하는 의료 장치 및 그 제조 방법 |
| JP2007312987A (ja) * | 2006-05-25 | 2007-12-06 | Kaneka Corp | ステント |
| TW201105738A (en) * | 2009-08-14 | 2011-02-16 | Nat Univ Chin Yi Technology | Method for preparing thermostable polylactic acid material by using sol-gel process |
| CN102702491A (zh) * | 2012-06-05 | 2012-10-03 | 云南民族大学 | 多臂聚乳酸组合物及其制备方法 |
| CN104231578A (zh) * | 2014-08-29 | 2014-12-24 | 四川大学 | 一种可完全生物降解聚酯材料及其制备与应用 |
| CN106957416A (zh) * | 2017-03-17 | 2017-07-18 | 复旦大学 | 可调节降解速率的[ptmc‑ga]‑[plla‑ga]嵌段聚酯及其制备方法 |
| CN110051889A (zh) * | 2019-04-24 | 2019-07-26 | 中国科学院长春应用化学研究所 | 一种聚乳酸纤维增强血管支架及其制备方法 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2308976C2 (ru) * | 2002-02-15 | 2007-10-27 | Си Ви Терапьютикс, Инк. | Полимерное покрытие для медицинских устройств |
| US11039943B2 (en) * | 2013-03-12 | 2021-06-22 | Micell Technologies, Inc. | Bioabsorbable biomedical implants |
| KR102302544B1 (ko) * | 2019-03-26 | 2021-09-15 | 형태경 | 스텐트 제조용 생분해성 수지 조성물 |
-
2021
- 2021-11-30 KR KR1020210169090A patent/KR102407468B1/ko active IP Right Grant
-
2022
- 2022-11-16 CN CN202211431683.7A patent/CN116196486A/zh active Pending
- 2022-11-25 CA CA3182829A patent/CA3182829A1/fr active Pending
Patent Citations (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5320624A (en) * | 1991-02-12 | 1994-06-14 | United States Surgical Corporation | Blends of glycolide and/or lactide polymers and caprolactone and/or trimethylene carbonate polymers and absorbable surgical devices made therefrom |
| KR20070063511A (ko) * | 2004-08-13 | 2007-06-19 | 세타곤 인코포레이티드 | 나노 다공성 층을 구비하는 의료 장치 및 그 제조 방법 |
| JP2007312987A (ja) * | 2006-05-25 | 2007-12-06 | Kaneka Corp | ステント |
| TW201105738A (en) * | 2009-08-14 | 2011-02-16 | Nat Univ Chin Yi Technology | Method for preparing thermostable polylactic acid material by using sol-gel process |
| CN102702491A (zh) * | 2012-06-05 | 2012-10-03 | 云南民族大学 | 多臂聚乳酸组合物及其制备方法 |
| CN104231578A (zh) * | 2014-08-29 | 2014-12-24 | 四川大学 | 一种可完全生物降解聚酯材料及其制备与应用 |
| CN106957416A (zh) * | 2017-03-17 | 2017-07-18 | 复旦大学 | 可调节降解速率的[ptmc‑ga]‑[plla‑ga]嵌段聚酯及其制备方法 |
| CN110051889A (zh) * | 2019-04-24 | 2019-07-26 | 中国科学院长春应用化学研究所 | 一种聚乳酸纤维增强血管支架及其制备方法 |
Non-Patent Citations (1)
| Title |
|---|
| 杜旭;王勤;刘阳;马丽霞;王传栋;: "生物可降解三嵌段共聚物PLATMC-PEG-PLATMC的合成、表征及性能研究", 化学与生物工程, no. 04, 30 March 2017 (2017-03-30) * |
Also Published As
| Publication number | Publication date |
|---|---|
| CA3182829A1 (fr) | 2023-05-30 |
| KR102407468B1 (ko) | 2022-06-10 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination |