CN116194145A - 使用axl诱饵受体的癌症诊断方法 - Google Patents

使用axl诱饵受体的癌症诊断方法 Download PDF

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CN116194145A
CN116194145A CN202180064019.0A CN202180064019A CN116194145A CN 116194145 A CN116194145 A CN 116194145A CN 202180064019 A CN202180064019 A CN 202180064019A CN 116194145 A CN116194145 A CN 116194145A
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cancer
axl
treatment
leu
gas6
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盖尔·麦金太尔
雷·塔比比亚扎
伊丽莎白·加德纳
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Alaviv
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    • C12Y207/10001—Receptor protein-tyrosine kinase (2.7.10.1)
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    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
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    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A61K31/502—Pyridazines; Hydrogenated pyridazines ortho- or peri-condensed with carbocyclic ring systems, e.g. cinnoline, phthalazine
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    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/513—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim having oxo groups directly attached to the heterocyclic ring, e.g. cytosine
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    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/177—Receptors; Cell surface antigens; Cell surface determinants
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CN202180064019.0A 2020-07-19 2021-07-18 使用axl诱饵受体的癌症诊断方法 Pending CN116194145A (zh)

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US202063053679P 2020-07-19 2020-07-19
US63/053,679 2020-07-19
PCT/US2021/042124 WO2022020218A1 (en) 2020-07-19 2021-07-18 Diagnostic methods for cancer using axl decoy receptors

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CN116194145A true CN116194145A (zh) 2023-05-30

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EP (1) EP4181961A4 (https=)
JP (1) JP2023535352A (https=)
KR (1) KR20230050349A (https=)
CN (1) CN116194145A (https=)
AU (1) AU2021312139A1 (https=)
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EP4693690A1 (en) 2023-04-17 2026-02-11 LG Energy Solution, Ltd. Separator and electrochemical device including same

Citations (3)

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CN103154020A (zh) * 2010-01-22 2013-06-12 小利兰·斯坦福大学托管委员会 抗转移疗法中axl信号传导的抑制
WO2019090227A1 (en) * 2017-11-04 2019-05-09 Aravive Biologics, Inc. Methods of treating metastatic cancers using axl decoy receptors
WO2019195753A1 (en) * 2018-04-05 2019-10-10 Tolero Pharmaceuticals, Inc. Axl kinase inhibitors and use of the same

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Publication number Priority date Publication date Assignee Title
CA2749601C (en) * 2009-01-14 2020-07-21 Stephen M. Hewitt Ratio based biomarkers and methods of use thereof

Patent Citations (3)

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Publication number Priority date Publication date Assignee Title
CN103154020A (zh) * 2010-01-22 2013-06-12 小利兰·斯坦福大学托管委员会 抗转移疗法中axl信号传导的抑制
WO2019090227A1 (en) * 2017-11-04 2019-05-09 Aravive Biologics, Inc. Methods of treating metastatic cancers using axl decoy receptors
WO2019195753A1 (en) * 2018-04-05 2019-10-10 Tolero Pharmaceuticals, Inc. Axl kinase inhibitors and use of the same

Non-Patent Citations (2)

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Title
KARINE FLEM-KARLSEN等: "Soluble AXL as a marker of disease progression and survival in melanoma", PLOS ONE, vol. 15, no. 1, 9 January 2020 (2020-01-09), pages 1 - 17, XP093135843, DOI: 10.1371/journal.pone.0227187 *
MAI TANAKA等: "Gas6/Axl Signaling Pathway in the Tumor Immune Microenvironment", CANCER, vol. 12, no. 7, 9 July 2020 (2020-07-09), pages 1 - 14, XP093136104, DOI: 10.3390/cancers12071850 *

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US20230277631A1 (en) 2023-09-07
JP2023535352A (ja) 2023-08-17
CA3185356A1 (en) 2022-01-27
EP4181961A4 (en) 2024-07-10
EP4181961A1 (en) 2023-05-24
MX2023000810A (es) 2023-05-19
AU2021312139A1 (en) 2023-03-02
KR20230050349A (ko) 2023-04-14

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