CN116098838A - 一种皮肤修复组合物及应用 - Google Patents
一种皮肤修复组合物及应用 Download PDFInfo
- Publication number
- CN116098838A CN116098838A CN202310084769.5A CN202310084769A CN116098838A CN 116098838 A CN116098838 A CN 116098838A CN 202310084769 A CN202310084769 A CN 202310084769A CN 116098838 A CN116098838 A CN 116098838A
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- Prior art keywords
- acid
- skin
- skin repair
- composition
- ointment
- Prior art date
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Abstract
本发明属于护肤品技术领域,具体涉及一种皮肤修复组合物及应用。所述皮肤修复组合物,包括以下组分:液体石蜡、氧化玉米油、亚麻酸、亚油酸、棕榈酸、维生素E、硬脂酸、冰片。组合物中的亚麻酸和亚油酸能够促进皮肤再生和重建,更好地改善皮肤保湿性;通过介入角质层的结合,防止透皮水分散失和加强脂质屏障。将所述组合物用于皮肤修复药膏中可用于褥疮轻症的治疗。所述药膏中包含按质量分数计的以下组分:皮肤修复组合物40‑70%,透明质酸钠10~20%;胶原蛋白5~10%;紫草素5~10%;水杨酸10~20%。药膏中的紫草素、水杨酸均具有抗炎、杀菌的作用,有利于褥疮患处的修复。
Description
技术领域
本发明属于护肤品技术领域,具体涉及一种皮肤修复组合物及应用。
背景技术
在人体复杂的免疫系统中,皮肤属于免疫功能的第一道防线,是人体最大的器官,对于人体健康十分重要。皮肤由表皮、真皮和皮下组织构成,并含有附属器官以及血管、淋巴管、神经和肌肉等。由于皮肤裸露在人体最外部,最易受细菌、真菌等的感染而受损。其中,褥疮及皮肤瘙痒是两种常见的皮肤病。
褥疮是由于局部组织长期受压,发生持续缺血、缺氧、营养不良而致的皮肤组织溃烂坏死,在康复治疗、护理中是一个普通性的问题。褥疮早期皮肤发红,采取翻身、减压等措施后可好转,同时使用药物治疗能够减缓病情发展、加快皮肤屏障修复。
皮肤瘙痒系指临床上无原发损害,且以瘙痒为主的感觉功能异常性皮肤病,在经过中由于搔抓可出现继发性皮肤损害,如抓痕、血痂等,十分影响患者的生活质量。皮肤瘙痒症患者中,老年人和儿童等免疫力低下者较为常见。
褥疮和皮肤瘙痒的治疗方法均有多种,但对于早期轻症的治疗,常采用涂抹护肤药膏的方式使病情缓解。目前市售护肤药膏有些含有激素,虽然治疗效果较好,但长期使用会产生依赖性,并且患者及家属主观上不易接受激素药膏的使用;另外不含激素的护肤膏虽然避免了激素的副作用,但皮肤修复效果缓慢或不佳。因此,开发一种新型的不含激素的护肤膏,对于缓解褥疮、皮肤瘙痒,促进皮肤修复和新生具有重要意义。
发明内容
为了实现上述目的,本发明提供以下技术方案:
本发明提供一种皮肤修复组合物,包括以下组分:液体石蜡或矿脂、氧化玉米油、亚麻酸、亚油酸、棕榈酸、维生素E、硬脂酸、冰片。
亚麻酸能抑制酪氨酸酶,对抗黑色素生成,防止色素沉着,增进血液流通和细胞新陈代谢,利于皮肤和毛发的调理和营养,因而被广泛应用于化妆品领域。亚麻酸是人体必需脂肪酸之一,能够降解血栓,使血流顺畅。可使血压降低,还具有改善过敏性皮炎、花粉症、气管哮喘等疾病的作用。保持皮肤弹性;抗炎症,有效抵抗皮肤敏感,有效对抗干性和衰老皮肤。
亚油酸和γ-亚麻酸:促进皮肤再生和重建,更好地改善皮肤保湿性;通过介入角质层的结合,防止透皮水分散失和加强脂质屏障;
维生素E,又称维他命E、生育酚,是一种脂溶性维生素,是最主要的抗氧化剂之一。主要功效和作用:1)美容养颜。防止皮肤老化,增强细胞活力,让肌肤保持弹性和光泽;能帮助皮肤变得白皙光滑;淡化色斑,清除脸部色素斑。2)延缓衰老。维生素E能够与身体自由基结合,防止细胞被氧化,从而帮助抗衰老。3)增强生育能力。维生素E能促进性激素分泌,使男子精子活力和数量增加;使女子雌性激素浓度增高,提高生育能力,预防流产。4)帮助防治心血管疾病。维生素E能防止血管内的血液凝固,防止动脉粥样硬化,进而使血液循环良好,使血管保持年轻状态以预防多种疾病。维生素E外用方法:秋冬保湿。5)对于受到如烧烫伤的伤害后,能促进皮肤愈合及减少疤痕形成。7)其优良的抗氧化作用,可以有效地保护双键防止被氧化。
液体石蜡:起到了顺滑保湿的效果,作为保湿剂用在化妆品和护肤品中,避免护肤品和化妆品用在肌肤上会过于干燥。
冰片:具有开窍醒神,清热止痛的功效。用于风热感冒,温病初起。本品辛以发散,凉以清热,清轻凉散,为疏散风热常用之品。
优选的,所述组合物包括按质量分数计的以下组分:液体石蜡或矿脂10~50%;氧化玉米油0~45%;亚麻酸10~60%;亚油酸1~15%;棕榈酸0.8~10%;维生素E1~2.5%;硬脂酸0.5~4.0%;冰片0.1~1.0%。
进一步优选的,所述组合物包括按质量分数计的以下组分:液体石蜡或矿脂40%;氧化玉米油38%;亚麻酸12.5%;亚油酸2.5%;棕榈酸3.0%;维生素E 2%;硬脂酸0.8%;冰片0.1~0.2%。
优选的,所述组合物中亚麻酸和亚油酸质量比为(5-10):1。
本发明还提供上述组合物的制备方法,包括以下步骤:将所述液体石蜡或矿脂、氧化玉米油、亚麻酸、亚油酸、棕榈酸、维生素E、硬脂酸、冰片混合,搅拌均匀,得到所述组合物。
本发明还提供上述组合物在皮肤修复用品中的应用,所述皮肤修复用品为医用敷料、药膏、护肤霜中的任意一种。
本发明还提供一种皮肤修复药膏,所述药膏包含上述皮肤修复组合物,所述药膏包含按质量分数计的以下组分:皮肤修复组合物40-70%,透明质酸钠10~20%;胶原蛋白5~10%;紫草素5~10%;水杨酸10~20%。
本发明与现有技术相比具有以下优点:
(1)本发明的皮肤修复组合物和药膏不含激素,副作用较小。
(2)本发明的皮肤修复组合物中含有亚麻酸,亚麻酸能够促进皮肤再生和重建,液体石蜡能改善皮肤保湿性,能够用于褥疮和皮肤瘙痒导致的皮肤受损,加快皮肤修复和新生。
(3)本发明的皮肤修复组合物及药膏的成分协同发挥作用,能够在抑菌消炎的同时起到促进皮肤修复的作用。
具体实施方式
下面结合具体实施例来进一步描述本发明,本发明的优点和特点将会随着描述而更为清楚。但实施例仅是范例性的,并不对本发明的范围构成任何限制。本领域技术人员应该理解的是,在不偏离本发明的精神和范围下可以对本发明技术方案的细节和形式进行修改或替换,但这些修改和替换均落入本发明的保护范围内。
以下实施例或对比例中所用的材料均为市售产品。
实施例1
一种皮肤修复组合物,按质量分数计,包括以下组分:
液体石蜡40%;氧化玉米油39%;亚麻酸12.5%;亚油酸2.5%;棕榈酸3.0%;维生素E 2%;硬脂酸0.8%;冰片0.1~0.2%。
所述组合物的制备方法包括以下步骤:将上述液体石蜡、氧化玉米油、亚麻酸、亚油酸、棕榈酸、维生素E、硬脂酸、冰片在洁净的容器中混合搅拌均匀,得到所述皮肤修复组合物。
实施例2
一种皮肤修复组合物,按质量分数计,包括以下组分:
液体石蜡30%;氧化玉米油39%;亚麻酸22.5%;亚油酸2.5%;棕榈酸3.0%;维生素E 2%;硬脂酸0.8%;冰片0.1~0.2%。所述组合物制备方法为将上述组分物理混合。
实施例3
一种皮肤修复组合物,按质量分数计,包括以下组分:
液体石蜡45%;亚麻酸40%;亚油酸8%;棕榈酸4%;维生素E 2%;硬脂酸0.8%;冰片0.1~0.2%。所述组合物制备方法为将上述组分物理混合。
实施例4
液体石蜡34%;亚麻酸50%;亚油酸5%;棕榈酸8%;维生素E 2%;硬脂酸0.8%;冰片0.1~0.2%。所述组合物制备方法为将上述组分物理混合。
实施例5
一种皮肤修复组合物,按质量分数计,包括以下组分:
液体石蜡20%;氧化玉米油38%;亚麻酸32.5%;亚油酸3.5%;棕榈酸3.0%;维生素E 2%;硬脂酸0.8%;冰片0.1~0.2%。所述组合物制备方法为将上述组分物理混合。
实施例6
一种皮肤修复组合物,按质量分数计,包括以下组分:
液体石蜡20%;氧化玉米油45%;亚麻酸20%;亚油酸2%;棕榈酸10%;维生素E2%;硬脂酸0.8%;冰片0.1~0.2%。所述组合物制备方法为将上述组分物理混合。
实施例7
一种皮肤修复组合物,按质量分数计,包括以下组分:
矿脂10%;氧化玉米油40%;亚麻酸35%;亚油酸8%;棕榈酸0.8%;维生素E 2%;硬脂酸4%;冰片0.1~0.2%。所述组合物制备方法为将上述组分物理混合。
实施例8
一种皮肤修复组合物,按质量分数计,包括以下组分:
矿脂17%;亚麻酸60%;亚油酸10%;棕榈酸10%;维生素E 2%;硬脂酸0.8%;冰片0.1~0.2%。所述组合物制备方法为将上述组分物理混合。
实施例9
一种皮肤修复药膏,按质量分数计,包括以下组分:
实施例1中的皮肤修复组合物50%,透明质酸钠20%;胶原蛋白10%;紫草素10%;水杨酸10%。所述药膏制备方法为将上述组分物理混合。
实施例10
一种皮肤修复药膏,按质量分数计,包括以下组分:
实施例2中的皮肤修复组合物50%,透明质酸钠20%;胶原蛋白10%;紫草素10%;水杨酸10%。所述药膏制备方法为将上述组分物理混合。
实施例11
一种皮肤修复药膏,按质量分数计,包括以下组分:
实施例3中的皮肤修复组合物50%,透明质酸钠20%;胶原蛋白10%;紫草素10%;水杨酸10%。所述药膏制备方法为将上述组分物理混合。
实施例12
一种皮肤修复药膏,按质量分数计,包括以下组分:
实施例4中的皮肤修复组合物50%,透明质酸钠20%;胶原蛋白10%;紫草素10%;水杨酸10%。所述药膏制备方法为将上述组分物理混合。
实施例13
一种皮肤修复药膏,按质量分数计,包括以下组分:
实施例5中的皮肤修复组合物50%,透明质酸钠20%;胶原蛋白10%;紫草素10%;水杨酸10%。所述药膏制备方法为将上述组分物理混合。
实施例14
一种皮肤修复药膏,按质量分数计,包括以下组分:
实施例6中的皮肤修复组合物50%,透明质酸钠20%;胶原蛋白10%;紫草素10%;水杨酸10%。所述药膏制备方法为将上述组分物理混合。
实施例15
一种皮肤修复药膏,按质量分数计,包括以下组分:
实施例7中的皮肤修复组合物50%,透明质酸钠20%;胶原蛋白10%;紫草素10%;水杨酸10%。所述药膏制备方法为将上述组分物理混合。
实施例16
一种皮肤修复药膏,按质量分数计,包括以下组分:
实施例1中的皮肤修复组合物50%,透明质酸钠10%;胶原蛋白10%;紫草素10%;水杨酸20%。所述药膏制备方法为将上述组分物理混合。
实施例17
一种皮肤修复药膏,按质量分数计,包括以下组分:
实施例1中的皮肤修复组合物60%,透明质酸钠15%;胶原蛋白5%;紫草素10%;水杨酸10%。所述药膏制备方法为将上述组分物理混合。
实施例18
一种皮肤修复药膏,按质量分数计,包括以下组分:
实施例1中的皮肤修复组合物40%,透明质酸钠20%;胶原蛋白10%;紫草素10%;水杨酸20%。所述药膏制备方法为将上述组分物理混合。
对比例1
一种皮肤修复药膏,按质量分数计,包括以下组分:
液体石蜡29.5%;氧化玉米油19%;维生素E1%;硬脂酸0.4%;冰片0.1%;透明质酸钠20%;胶原蛋白10%;紫草素10%;水杨酸10%。所述药膏制备方法为将上述组分物理混合。
对比例2
一种皮肤修复药膏,按质量分数计,包括以下组分:
液体石蜡20%;氧化玉米油19.5%;维生素E1%;亚麻酸1%;亚油酸6.5%;棕榈酸1.5%;硬脂酸0.4%;冰片0.1%;透明质酸钠20%;胶原蛋白10%;紫草素10%;水杨酸10%。所述药膏制备方法为将上述组分物理混合。
对比例3
一种皮肤修复药膏,按质量分数计,包括以下组分:
液体石蜡12%;氧化玉米油11.7%;维生素E 0.6%;亚麻酸3.75%;亚油酸0.75%;棕榈酸0.9%;硬脂酸0.24%;冰片0.06%;透明质酸钠30%;胶原蛋白15%;紫草素10%;水杨酸15%。所述药膏制备方法为将上述组分物理混合。
对比例4
一种皮肤修复药膏,按质量分数计,包括以下组分:
液体石蜡20%;氧化玉米油19.5%;维生素E1%;亚油酸7.5%;棕榈酸1.5%;硬脂酸0.4%;冰片0.1%;透明质酸钠20%;胶原蛋白10%;紫草素10%;水杨酸10%。所述药膏制备方法为将上述组分物理混合。
应用例
选择20位背部患有大面积一级褥疮的年龄在70-80岁的患者作为受试者,在每位患者的大面积患处中均划分出15处等面积的患处,对其中14处患处分别等量均匀涂抹实施例9-18、对比例1-4的皮肤修复药膏,第15处作空白对照。涂抹之后避免背部着床,连续涂抹直至褥疮治愈,其他护理措施条件相同,进行观察,褥疮恢复情况如表1。
表1.一级褥疮受试者背部褥疮恢复情况
由表1可知,20位受试者在使用本发明的皮肤修复药膏之后,一级褥疮患处恢复时间为6-22天,而不使用任何药膏的褥疮患处,仅通过普通护理,恢复时间为19-38天。
对比例1的药膏中未采用亚麻酸、亚油酸、棕榈酸;对比例2中的药膏亚麻酸与亚油酸的用量比为1:6.5;对比例3药膏中的皮肤修复组合物用量太少;对比例4药膏中仅含有亚油酸;同一患者使用对比例1-4中的药膏,褥疮恢复时间明显延长。
经实验发现,本发明的药膏同时对于皮肤瘙痒具有良好的治疗效果。
Claims (7)
1.一种皮肤修复组合物,其特征在于,包括以下组分:液体石蜡或矿脂、氧化玉米油、亚麻酸、亚油酸、棕榈酸、维生素E、硬脂酸、冰片。
2.根据权利要求1所述的皮肤修复组合物,其特征在于,所述组合物包括按质量分数计的以下组分:液体石蜡或矿脂10~50%;氧化玉米油0~45%;亚麻酸10~60%;亚油酸1~15%;棕榈酸0.8~10%;维生素E1~2.5%;硬脂酸0.5~4.0%;冰片0.1~1.0%。
3.根据权利要求2所述的皮肤修复组合物,其特征在于,所述组合物包括按质量分数计的以下组分:液体石蜡或矿脂40%;氧化玉米油38%;亚麻酸12.5%;亚油酸2.5%;棕榈酸3.0%;维生素E 2%;硬脂酸0.8%;冰片0.1~0.2%。
4.根据权利要求2所述的皮肤修复组合物,其特征在于,所述组合物中亚麻酸和亚油酸质量比为(5-10):1。
5.根据权利要求1~4所述的皮肤修复组合物的制备方法,其特征在于,包括以下步骤:将所述液体石蜡或矿脂、氧化玉米油、亚麻酸、亚油酸、棕榈酸、维生素E、硬脂酸、冰片混合,搅拌均匀,得到所述组合物。
6.根据权利要求1~4所述的皮肤修复组合物在皮肤修复用品中的应用,所述皮肤修复用品为医用敷料、药膏、护肤霜中的任意一种。
7.一种皮肤修复药膏,所述药膏包含上述皮肤修复组合物,所述药膏包含按质量分数计的以下组分:皮肤修复组合物40-70%,透明质酸钠10~20%;胶原蛋白5~10%;紫草素5~10%;水杨酸10~20%。
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