CN116056702B - 治疗高胆固醇血症的方法 - Google Patents

治疗高胆固醇血症的方法

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Publication number
CN116056702B
CN116056702B CN202180050829.0A CN202180050829A CN116056702B CN 116056702 B CN116056702 B CN 116056702B CN 202180050829 A CN202180050829 A CN 202180050829A CN 116056702 B CN116056702 B CN 116056702B
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CN
China
Prior art keywords
cholesterol
compound
disease
subject
pharmaceutically acceptable
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
CN202180050829.0A
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English (en)
Chinese (zh)
Other versions
CN116056702A (zh
Inventor
S·贝拉丘
E·卡西尔麦克法兰
Z·邵
H-H·蔡
R·魏
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bojian Massachusetts Co ltd
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Bojian Massachusetts Co ltd
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Publication of CN116056702A publication Critical patent/CN116056702A/zh
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/451—Non condensed piperidines, e.g. piperocaine having a carbocyclic group directly attached to the heterocyclic ring, e.g. glutethimide, meperidine, loperamide, phencyclidine, piminodine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CN202180050829.0A 2020-08-19 2021-08-19 治疗高胆固醇血症的方法 Active CN116056702B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202063067786P 2020-08-19 2020-08-19
US63/067,786 2020-08-19
PCT/US2021/046591 WO2022040371A1 (en) 2020-08-19 2021-08-19 Methods for treating hypercholesterolemia

Publications (2)

Publication Number Publication Date
CN116056702A CN116056702A (zh) 2023-05-02
CN116056702B true CN116056702B (zh) 2026-01-23

Family

ID=77693631

Family Applications (1)

Application Number Title Priority Date Filing Date
CN202180050829.0A Active CN116056702B (zh) 2020-08-19 2021-08-19 治疗高胆固醇血症的方法

Country Status (5)

Country Link
US (1) US12472171B2 (https=)
EP (1) EP4199928B1 (https=)
JP (1) JP7824930B2 (https=)
CN (1) CN116056702B (https=)
WO (1) WO2022040371A1 (https=)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR112021013807A2 (pt) 2019-01-18 2021-11-30 Astrazeneca Ab Inibidores de pcsk9 e seus métodos de uso
MX2021008661A (es) 2019-01-18 2021-08-19 Astrazeneca Ab Inhibidores de la pcsk9 y metodos de uso de los mismos.

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN116096421A (zh) * 2020-08-19 2023-05-09 渤健马萨诸塞州股份有限公司 用于治疗缓解型多发性硬化的方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPWO2002053568A1 (ja) * 2000-12-28 2004-05-13 持田製薬株式会社 スピロ結合を有する三環系化合物を有効成分とするコレステロール生合成阻害剤
PL1643983T3 (pl) * 2003-06-24 2010-10-29 Univ Connecticut Sposoby hamowania przepuszczalności naczyń krwionośnych i apoptozy
EA034451B1 (ru) * 2011-02-07 2020-02-10 Байоджен Ма Инк. Модуляторы s1p
JP6324380B2 (ja) * 2012-07-27 2018-05-16 バイオジェン・エムエイ・インコーポレイテッドＢｉｏｇｅｎ ＭＡ Ｉｎｃ． Ｓ１ｐ調節剤および／またはａｔｘ調節剤である化合物

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN116096421A (zh) * 2020-08-19 2023-05-09 渤健马萨诸塞州股份有限公司 用于治疗缓解型多发性硬化的方法

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
Development of an Early Phase Process for a Potent Oligodendrocyte Precursor Cell Differentiator;Donald G. Walker等;Organic Process Research & Development;20240209;2203–2212 *

Also Published As

Publication number Publication date
US12472171B2 (en) 2025-11-18
EP4199928A1 (en) 2023-06-28
JP7824930B2 (ja) 2026-03-05
CN116056702A (zh) 2023-05-02
WO2022040371A1 (en) 2022-02-24
EP4199928B1 (en) 2025-11-26
US20230310405A1 (en) 2023-10-05
JP2023538066A (ja) 2023-09-06

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