CN116033920A - 大序列泛冠状病毒疫苗组合物 - Google Patents

大序列泛冠状病毒疫苗组合物 Download PDF

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Publication number
CN116033920A
CN116033920A CN202180042301.9A CN202180042301A CN116033920A CN 116033920 A CN116033920 A CN 116033920A CN 202180042301 A CN202180042301 A CN 202180042301A CN 116033920 A CN116033920 A CN 116033920A
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composition
coronavirus
protein
cell
conserved
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L·本穆罕默德
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University of California San Diego UCSD
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University of California San Diego UCSD
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A61K39/215—Coronaviridae, e.g. avian infectious bronchitis virus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • C07K14/08—RNA viruses
    • C07K14/165—Coronaviridae, e.g. avian infectious bronchitis virus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/545—Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55522—Cytokines; Lymphokines; Interferons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/57—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/57—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2
    • A61K2039/575—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2 humoral response
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/70—Multivalent vaccine
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
    • C12N2770/00011—Details
    • C12N2770/20011—Coronaviridae
    • C12N2770/20034—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Virology (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Communicable Diseases (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Molecular Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Oncology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pulmonology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
CN202180042301.9A 2020-04-14 2021-04-14 大序列泛冠状病毒疫苗组合物 Pending CN116033920A (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US202063009907P 2020-04-14 2020-04-14
US63/009,907 2020-04-14
US202063084421P 2020-09-28 2020-09-28
US63/084,421 2020-09-28
PCT/US2021/027355 WO2021211760A1 (en) 2020-04-14 2021-04-14 Large sequence pan-coronavirus vaccine compositions

Publications (1)

Publication Number Publication Date
CN116033920A true CN116033920A (zh) 2023-04-28

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CN202180042301.9A Pending CN116033920A (zh) 2020-04-14 2021-04-14 大序列泛冠状病毒疫苗组合物

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US (1) US20230226173A1 (https=)
EP (3) EP4135764A4 (https=)
JP (1) JP2023521837A (https=)
KR (1) KR20230002571A (https=)
CN (1) CN116033920A (https=)
AU (1) AU2021254768A1 (https=)
CA (1) CA3178834A1 (https=)
IL (1) IL297335A (https=)
WO (3) WO2021211749A1 (https=)

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CN117903264A (zh) * 2023-10-26 2024-04-19 中国人民解放军海军军医大学 新冠病毒SARS-CoV-2 HLA-A2限制性表位肽及应用

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AU2022308712A1 (en) * 2021-07-09 2023-12-21 Atossa Therapeutics, Inc. Compositions and methods to increase coronavirus immune response
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WO2023044542A1 (en) * 2021-09-24 2023-03-30 The University Of Adelaide Sars cov-2 vaccine
CN114395017B (zh) * 2021-10-29 2024-08-13 中国科学院深圳先进技术研究院 SARS-CoV-2病毒样颗粒的制备方法及其应用
EP4176898A1 (en) * 2021-11-08 2023-05-10 Charité - Universitätsmedizin Berlin Pan sars-cov2 vaccine antigen
US12186387B2 (en) 2021-11-29 2025-01-07 BioNTech SE Coronavirus vaccine
CN114181320B (zh) * 2021-12-09 2023-04-25 新疆医科大学第一附属医院 一种针对新冠原始株和变异株的重组多表位疫苗rSMEV及其应用
CN114478716B (zh) * 2021-12-28 2024-05-28 梅州市人民医院(梅州市医学科学院) 一种多肽组合及其在新型冠状病毒抗体检测中的应用
WO2023159082A2 (en) * 2022-02-15 2023-08-24 Ohio State Innovation Foundation Nanotechnology based intranasal vaccine for covid-19 comprising chitosan
WO2023240159A2 (en) * 2022-06-07 2023-12-14 The Regents Of The University Of California Sars-cov-2 multi-antigen universal vaccines
WO2024002985A1 (en) 2022-06-26 2024-01-04 BioNTech SE Coronavirus vaccine
WO2024011163A1 (en) * 2022-07-06 2024-01-11 Georgia State University Research Foundation, Inc. Coronavirus vaccines and methods of use thereof
WO2024064965A2 (en) * 2022-09-23 2024-03-28 Advanced Rna Vaccine (Arv) Technologies, Inc. Nucleic acid-based universal vaccine and methods of use thereof
WO2024074634A1 (en) * 2022-10-06 2024-04-11 BioNTech SE Rna compositions targeting claudin-18.2
CN116041540B (zh) * 2022-11-18 2025-10-17 中山大学 一种增强新冠突变株疫苗广谱性的方法及新冠广谱疫苗
WO2024191944A2 (en) * 2023-03-10 2024-09-19 The Regents Of The University Of California Broad-spectrum multi-antigen pan-coronavirus vaccine
WO2024206843A2 (en) * 2023-03-31 2024-10-03 University Of Kansas Compositions including modified coronavirus vaccines and uses thereof
WO2024222737A1 (zh) * 2023-04-28 2024-10-31 北京先声祥瑞生物制品股份有限公司 工程化的mRNA及其用途
CN117330750A (zh) * 2023-12-01 2024-01-02 北京生物制品研究所有限责任公司 一种筛选新冠病毒早期毒种的方法和制造疫苗的方法

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Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN114591401A (zh) * 2021-05-18 2022-06-07 深圳市因诺转化医学研究院 SARS-CoV-2编码蛋白来源的T细胞表位多肽HLVDFQVTI及其应用
CN117903264A (zh) * 2023-10-26 2024-04-19 中国人民解放军海军军医大学 新冠病毒SARS-CoV-2 HLA-A2限制性表位肽及应用

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JP2023521837A (ja) 2023-05-25
EP4135762A1 (en) 2023-02-22
EP4135762A4 (en) 2024-05-15
WO2021211749A1 (en) 2021-10-21
EP4135765A4 (en) 2024-05-08
AU2021254768A1 (en) 2022-11-17
WO2021211748A1 (en) 2021-10-21
US20230226173A1 (en) 2023-07-20
WO2021211760A1 (en) 2021-10-21
KR20230002571A (ko) 2023-01-05
CA3178834A1 (en) 2021-10-21
EP4135764A1 (en) 2023-02-22
IL297335A (en) 2022-12-01
EP4135764A4 (en) 2024-05-08
EP4135765A1 (en) 2023-02-22

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