CN115968401A - 将干细胞分化为多巴胺能祖细胞的方法 - Google Patents
将干细胞分化为多巴胺能祖细胞的方法 Download PDFInfo
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- CN115968401A CN115968401A CN202180044066.9A CN202180044066A CN115968401A CN 115968401 A CN115968401 A CN 115968401A CN 202180044066 A CN202180044066 A CN 202180044066A CN 115968401 A CN115968401 A CN 115968401A
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB2006792.2 | 2020-05-07 | ||
| GBGB2006792.2A GB202006792D0 (en) | 2020-05-07 | 2020-05-07 | Method and uses thereof |
| PCT/EP2021/062226 WO2021224496A1 (en) | 2020-05-07 | 2021-05-07 | Methods for differentiating stem cells into dopaminergic progenitor cells |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN115968401A true CN115968401A (zh) | 2023-04-14 |
Family
ID=71134903
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202180044066.9A Pending CN115968401A (zh) | 2020-05-07 | 2021-05-07 | 将干细胞分化为多巴胺能祖细胞的方法 |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US20230233617A1 (https=) |
| EP (1) | EP4146796A1 (https=) |
| JP (1) | JP2023525297A (https=) |
| CN (1) | CN115968401A (https=) |
| CA (1) | CA3182115A1 (https=) |
| GB (1) | GB202006792D0 (https=) |
| WO (1) | WO2021224496A1 (https=) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN117448270A (zh) * | 2023-12-22 | 2024-01-26 | 上海元戊医学技术有限公司 | 一种高效诱导多能干细胞分化为中脑多巴胺能神经前体细胞的方法 |
| CN117660335A (zh) * | 2023-12-14 | 2024-03-08 | 广州百康细胞生命科技有限公司 | 一种使用化学重编辑法将体细胞转化成免疫细胞的方法 |
| WO2025026225A1 (zh) * | 2023-07-28 | 2025-02-06 | 士泽生物医药(苏州)有限公司 | 一种诱导干细胞分化为运动神经前体细胞和/或运动神经元的试剂盒及其应用 |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2022081501A1 (en) * | 2020-10-12 | 2022-04-21 | Research Development Foundation | Methods for making and using differentiated neural cells |
| AU2022247250A1 (en) | 2021-03-30 | 2023-11-09 | Trailhead Biosystems Inc. | Methods and compositions for generating oligodendrocyte progenitor cells |
| JP2025524856A (ja) * | 2022-07-21 | 2025-08-01 | トレイルヘッド バイオシステムズ インコーポレイテッド | 神経前駆細胞からヒト中脳ドーパミン作動性ニューロンを作製するための方法および組成物 |
| CN115521903B (zh) * | 2022-09-30 | 2024-05-17 | 中国科学院生态环境研究中心 | 体外诱导人多能干细胞分化为多巴胺能神经元的方法 |
| US12565639B2 (en) | 2023-06-13 | 2026-03-03 | Aspen Neuroscience, Inc. | Methods for differentiating dopaminergic neurons from stem cells |
| WO2025162486A1 (en) * | 2024-01-31 | 2025-08-07 | Center For Excellence In Brain Science And Intelligence Technology, Chinese Academy Of Sciences | An additive composition and a method for promoting differentiation into a10 precursors and/or a10 neurons |
| WO2025193168A1 (en) * | 2024-03-14 | 2025-09-18 | National University Of Singapore | Method of generating midbrain dopamine progenitors and neurons from stem cells |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101935635A (zh) * | 2010-07-30 | 2011-01-05 | 中国人民解放军第二军医大学 | 人骨髓多能干细胞的体外扩增和向多巴胺能神经元定向分化的方法 |
| US20130108669A1 (en) * | 2010-04-16 | 2013-05-02 | The Mclean Hospital Corporation | Dopaminergic neurons differentiated from pluripotent stem cells and uses of thereof |
| CN104379731A (zh) * | 2011-11-04 | 2015-02-25 | 纪念斯隆-凯特琳癌症中心 | 用于植入的中脑多巴胺(da)神经元 |
| CN104379732A (zh) * | 2012-04-24 | 2015-02-25 | 国际干细胞公司 | 由人多能干细胞衍生神经干细胞和多巴胺能神经元 |
| US20180243343A1 (en) * | 2015-02-26 | 2018-08-30 | The Mclean Hospital Corporation | Methods and compositions for the treatment or prevention of parkinson's disease |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2001088104A2 (en) * | 2000-05-17 | 2001-11-22 | Geron Corporation | Neural progenitor cell populations |
| WO2010096496A2 (en) * | 2009-02-17 | 2010-08-26 | Memorial Sloan-Kettering Cancer Center | Methods of neural conversion of human embryonic stem cells |
| ES2939807T3 (es) * | 2014-03-21 | 2023-04-27 | Fujifilm Cellular Dynamics Inc | Producción de neuronas dopaminérgicas del mesencéfalo y métodos para su utilización |
| US11767508B2 (en) * | 2017-07-24 | 2023-09-26 | Wisconsin Alumni Research Foundation | Methods and culture substrates for controlled induction of biomimetic neural tissues comprising singular rosette structures |
-
2020
- 2020-05-07 GB GBGB2006792.2A patent/GB202006792D0/en not_active Ceased
-
2021
- 2021-05-07 CA CA3182115A patent/CA3182115A1/en active Pending
- 2021-05-07 JP JP2022567835A patent/JP2023525297A/ja active Pending
- 2021-05-07 EP EP21724671.9A patent/EP4146796A1/en active Pending
- 2021-05-07 US US17/923,265 patent/US20230233617A1/en active Pending
- 2021-05-07 CN CN202180044066.9A patent/CN115968401A/zh active Pending
- 2021-05-07 WO PCT/EP2021/062226 patent/WO2021224496A1/en not_active Ceased
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20130108669A1 (en) * | 2010-04-16 | 2013-05-02 | The Mclean Hospital Corporation | Dopaminergic neurons differentiated from pluripotent stem cells and uses of thereof |
| CN101935635A (zh) * | 2010-07-30 | 2011-01-05 | 中国人民解放军第二军医大学 | 人骨髓多能干细胞的体外扩增和向多巴胺能神经元定向分化的方法 |
| CN104379731A (zh) * | 2011-11-04 | 2015-02-25 | 纪念斯隆-凯特琳癌症中心 | 用于植入的中脑多巴胺(da)神经元 |
| CN104379732A (zh) * | 2012-04-24 | 2015-02-25 | 国际干细胞公司 | 由人多能干细胞衍生神经干细胞和多巴胺能神经元 |
| US20180243343A1 (en) * | 2015-02-26 | 2018-08-30 | The Mclean Hospital Corporation | Methods and compositions for the treatment or prevention of parkinson's disease |
Non-Patent Citations (2)
| Title |
|---|
| OLIVER COOPER等: "Differentiation of human ES and Parkinson\'s disease iPS cells into ventral midbrain dopaminergic neurons requires a high activity form of SHH, FGF8a and specific regionalization by retinoic acid", MOLECULAR AND CELLULAR NEUROSCIENCE, vol. 45, 24 July 2010 (2010-07-24), pages 1 * |
| 潘宏旭等: "全反式维甲酸通过增强调节性T细胞的抑炎效应发挥对多巴胺能神经元的保护作用", 国际神经病学神经外科学杂志, 28 October 2017 (2017-10-28), pages 1 - 5 * |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2025026225A1 (zh) * | 2023-07-28 | 2025-02-06 | 士泽生物医药(苏州)有限公司 | 一种诱导干细胞分化为运动神经前体细胞和/或运动神经元的试剂盒及其应用 |
| CN117660335A (zh) * | 2023-12-14 | 2024-03-08 | 广州百康细胞生命科技有限公司 | 一种使用化学重编辑法将体细胞转化成免疫细胞的方法 |
| CN117448270A (zh) * | 2023-12-22 | 2024-01-26 | 上海元戊医学技术有限公司 | 一种高效诱导多能干细胞分化为中脑多巴胺能神经前体细胞的方法 |
Also Published As
| Publication number | Publication date |
|---|---|
| WO2021224496A1 (en) | 2021-11-11 |
| GB202006792D0 (en) | 2020-06-24 |
| JP2023525297A (ja) | 2023-06-15 |
| US20230233617A1 (en) | 2023-07-27 |
| CA3182115A1 (en) | 2021-11-11 |
| EP4146796A1 (en) | 2023-03-15 |
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