CN115916188A - 尼罗司他与bcma定向疗法的组合疗法及其用途 - Google Patents

尼罗司他与bcma定向疗法的组合疗法及其用途 Download PDF

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Publication number
CN115916188A
CN115916188A CN202180034598.4A CN202180034598A CN115916188A CN 115916188 A CN115916188 A CN 115916188A CN 202180034598 A CN202180034598 A CN 202180034598A CN 115916188 A CN115916188 A CN 115916188A
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bcma
nilostat
therapy
dihydrobromide
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Pending
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Chinese (zh)
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托德·韦伯斯特·希勒
巴德雷丁·伊德里斯
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Springworths Treatment Co ltd
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Springworths Treatment Co ltd
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
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    • A61K40/41—Vertebrate antigens
    • A61K40/42—Cancer antigens
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    • A61K40/4214—Receptors for cytokines
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  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
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CN202180034598.4A 2020-03-13 2021-03-12 尼罗司他与bcma定向疗法的组合疗法及其用途 Pending CN115916188A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202062989372P 2020-03-13 2020-03-13
US62/989,372 2020-03-13
PCT/US2021/022177 WO2021183934A1 (en) 2020-03-13 2021-03-12 A combination therapy with nirogacestat and a bcma-directed therapy and uses thereof

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CN115916188A true CN115916188A (zh) 2023-04-04

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US (1) US20230121547A1 (enExample)
EP (1) EP4132515A1 (enExample)
JP (2) JP7781764B2 (enExample)
KR (1) KR20230009873A (enExample)
CN (1) CN115916188A (enExample)
AR (1) AR121566A1 (enExample)
AU (1) AU2021236340A1 (enExample)
BR (1) BR112022018251A2 (enExample)
CA (1) CA3171267A1 (enExample)
CL (1) CL2022002479A1 (enExample)
CO (1) CO2022014388A2 (enExample)
IL (1) IL296075A (enExample)
MX (1) MX2022011258A (enExample)
PE (1) PE20230614A1 (enExample)
TW (1) TW202200132A (enExample)
WO (1) WO2021183934A1 (enExample)

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* Cited by examiner, † Cited by third party
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JP2024530795A (ja) 2021-09-01 2024-08-23 スプリングワークス、セラピューティクス、インコーポレイテッド ニロガセスタットの合成
WO2023064872A1 (en) * 2021-10-14 2023-04-20 Precision Biosciences, Inc. Combinations of anti-bcma car t cells and gamma secretase inhibitors
CN118338900A (zh) * 2021-11-05 2024-07-12 斯普林渥克斯治疗有限公司 含尼罗加司他的组合物和治疗
CN118302412A (zh) * 2021-11-23 2024-07-05 梯瓦制药国际有限责任公司 Nirogacestat盐的固态形式
US11951096B2 (en) 2022-05-20 2024-04-09 Springworks Therapeutics, Inc. Treatments with nirogacestat
US12138246B2 (en) 2022-05-20 2024-11-12 Springworks Therapeutics, Inc. Treatments with nirogacestat
US12036207B2 (en) 2022-05-20 2024-07-16 Springworks Therapeutics, Inc. Treatments with nirogacestat
US20230372301A1 (en) * 2022-05-20 2023-11-23 Springworks Therapeutics, Inc. Treatments with nirogacestat
AU2024231546A1 (en) * 2023-03-09 2025-10-02 Crystal Pharmaceutical (Suzhou) Co., Ltd. Crystal form of nirogacestat dihydrobromide, and preparation method therefor and use thereof

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US20180214553A1 (en) * 2015-07-24 2018-08-02 Oncotracker, Inc. Gamma secretase modulators for the treatment of immune system dysfunction
WO2018201051A1 (en) * 2017-04-28 2018-11-01 Novartis Ag Bcma-targeting agent, and combination therapy with a gamma secretase inhibitor
WO2019090364A1 (en) * 2017-11-06 2019-05-09 Juno Therapeutics, Inc. Combination of a cell therapy and a gamma secretase inhibitor
CN110461335A (zh) * 2017-02-17 2019-11-15 弗雷德哈钦森癌症研究中心 用于治疗bcma相关癌症和自身免疫性失调的联合疗法
US20190367628A1 (en) * 2018-06-01 2019-12-05 Novartis Ag Binding molecules against bcma and uses thereof
US20200055948A1 (en) * 2017-04-28 2020-02-20 Novartis Ag Cells expressing a bcma-targeting chimeric antigen receptor, and combination therapy with a gamma secretase inhibitor
CN112118842A (zh) * 2018-01-17 2020-12-22 明赛制药股份公司 用于癌症治疗的联合疗法
US20210171651A1 (en) * 2017-11-08 2021-06-10 Fred Hutchinson Cancer Research Center Bispecific antibody compositions and related methods for improved pretargeted radioimmunotherapies
US20220288088A1 (en) * 2018-05-24 2022-09-15 Ayala Pharmaceuticals Inc. Combination of immunotherapeutics and bisfluoroalkyl-1,4-benzodiazepinone compounds for treating cancer

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US10149855B2 (en) * 2014-02-05 2018-12-11 The Trustees Of Columbia University In The City Of New York Gamma-secretase inhibition reduce APOC3 levels and plasma triglycerides
JP7050813B2 (ja) * 2017-05-05 2022-04-08 華為技術有限公司 支援データ送信方法、デバイス、およびシステム
CN113924318B (zh) * 2019-04-10 2025-06-20 葛兰素史密斯克莱知识产权发展有限公司 具有抗BCMA抗体和gamma分泌酶抑制剂的联合疗法
JP7608435B2 (ja) * 2019-08-09 2025-01-06 ファイザー・インク （ｓ）－２－（（（ｓ）－６，８－ジフルオロ－１，２，３，４－テトラヒドロナフタレン－２－イル）アミノ）－ｎ－（１－（２－メチル－１－（ネオペンチルアミノ）プロパン－２－イル）－１ｈ－イミダゾール－４－イル）ペンタンアミドの固体状態形態およびその使用

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CN110461335A (zh) * 2017-02-17 2019-11-15 弗雷德哈钦森癌症研究中心 用于治疗bcma相关癌症和自身免疫性失调的联合疗法
WO2018201051A1 (en) * 2017-04-28 2018-11-01 Novartis Ag Bcma-targeting agent, and combination therapy with a gamma secretase inhibitor
US20200055948A1 (en) * 2017-04-28 2020-02-20 Novartis Ag Cells expressing a bcma-targeting chimeric antigen receptor, and combination therapy with a gamma secretase inhibitor
WO2019090364A1 (en) * 2017-11-06 2019-05-09 Juno Therapeutics, Inc. Combination of a cell therapy and a gamma secretase inhibitor
US20210171651A1 (en) * 2017-11-08 2021-06-10 Fred Hutchinson Cancer Research Center Bispecific antibody compositions and related methods for improved pretargeted radioimmunotherapies
CN112118842A (zh) * 2018-01-17 2020-12-22 明赛制药股份公司 用于癌症治疗的联合疗法
US20220288088A1 (en) * 2018-05-24 2022-09-15 Ayala Pharmaceuticals Inc. Combination of immunotherapeutics and bisfluoroalkyl-1,4-benzodiazepinone compounds for treating cancer
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MX2022011258A (es) 2023-01-11
JP2025168430A (ja) 2025-11-07
PE20230614A1 (es) 2023-04-14
CA3171267A1 (en) 2021-09-16
TW202200132A (zh) 2022-01-01
US20230121547A1 (en) 2023-04-20
AU2021236340A1 (en) 2022-09-29
CL2022002479A1 (es) 2023-08-18
WO2021183934A1 (en) 2021-09-16
IL296075A (en) 2022-11-01
EP4132515A1 (en) 2023-02-15
BR112022018251A2 (pt) 2022-11-08
JP2023517243A (ja) 2023-04-24
AR121566A1 (es) 2022-06-15
JP7781764B2 (ja) 2025-12-08
CO2022014388A2 (es) 2023-02-16

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