CN115887585A - Alcohol-dispelling and liver-protecting atomized liquid containing extract and preparation method thereof - Google Patents
Alcohol-dispelling and liver-protecting atomized liquid containing extract and preparation method thereof Download PDFInfo
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- CN115887585A CN115887585A CN202210462542.5A CN202210462542A CN115887585A CN 115887585 A CN115887585 A CN 115887585A CN 202210462542 A CN202210462542 A CN 202210462542A CN 115887585 A CN115887585 A CN 115887585A
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Abstract
The invention discloses an alcohol-dispelling and liver-protecting atomized liquid containing an extract, wherein the prepared atomized stock solution can effectively reduce the liver transaminase and cholesterol level, accelerate alcohol metabolism, quickly decompose alcohol in vivo, prevent drunkenness and subsequent discomfort to a certain extent, reduce the alcohol content in blood and simultaneously protect the liver health by adding an anti-enzyme active substance, hyaluronic acid, calcium sodium phosphosilicate, beta-nicotinamide adenine dinucleotide, the extract, vitamins and edible essence; and simultaneously, the regeneration capability of the liver-protecting powder can be enhanced, and the liver can be protected from being damaged by hepatotoxicity. The preparation method is simple, the stability of the atomized stock solution is strong, the decomposition of active ingredients cannot occur within half a year under the acceleration condition, the fog saturation is high, the formula is safe, the toxic and side effects are avoided, the taste is good, the taste saturation is high, the problem of dry mouth and throat irritation cannot be caused, and the use is convenient.
Description
Technical Field
The invention relates to the field of preparation of anti-alcoholism and liver-protecting medicaments, in particular to A61P39/02, and especially relates to an anti-alcoholism and liver-protecting atomized liquid containing an extract and a preparation method thereof.
Background
Everyone has independent social circle, needs to contact with different people, can inevitably contact wine in the environment of work or party, and under the continuous renewal of healthy theory, people also can select to utilize the dazing to alleviate the pressure in life, work, but different people are different to the reaction degree of alcohol, can appear problems such as alcohol allergy, alcoholism. In addition, after the alcohol enters the human body, only a small part of the alcohol is discharged along with expiration or sweat glands, more of the alcohol enters the human body and is diffused to the whole body along with blood, the alcohol is mainly distributed in the brain and the liver, the alcohol in the liver can generate acetaldehyde under the action of alcohol dehydrogenase, the acetaldehyde is toxic to the human body, the acetaldehyde is converted into acetic acid under the action of the acetaldehyde dehydrogenase, energy is provided for the human body, and the acetaldehyde dehydrogenase in the human body is relatively less. Therefore, if alcohol is drunk for a long time or in a large amount, alcohol is accumulated in the brain and the liver, the metabolic capability of the liver is weakened, the content of fat in the liver is increased, the alcoholic liver is formed, and the liver cirrhosis disease is induced in a serious case.
Patent CN201911352784.3 discloses a liver-protecting Chinese herbal medicine product for alleviating hangover and a preparation method thereof, wherein the product is prepared by taking xiancao juice, fresh thistle, chrysanthemum, mulberry, galangal and lalang grass rhizome as active ingredients, so that in-vivo alcohol decomposition and acetaldehyde conversion are accelerated, harm of ethanol to a human body is reduced, and the purpose of protecting the liver is achieved. Patent CN201710258614.3 discloses a hovenia dulcis thunb health beverage capable of relieving alcoholism and protecting liver and a preparation method thereof, wherein active ingredients such as hovenia dulcis thunb extract, kudzu root extract, corn oligopeptide powder, taurine, vitamin B6, vitamin B12, vitamin C and the like are utilized to relieve visual fatigue, increase physical strength and keep spiritual health while relieving alcoholism, but the traditional Chinese medicine sobering and protecting liver products only singly play a liver protection role by accelerating metabolism discharge of acetaldehyde, so that the liver protection function is weak, cell regeneration cannot be promoted, and the recovery capability of liver function is improved.
Disclosure of Invention
In order to solve the above problems, the invention provides, in a first aspect, an anti-hangover and liver-protecting atomized liquid containing an extract, which is prepared from the following raw materials: the weight percentage is as follows:
0.05 to 1 percent of enzyme-resistant active substance, 0.05 to 6 percent of hyaluronic acid, 1 to 12 percent of calcium sodium phosphosilicate, 0.05 to 3 percent of beta-nicotinamide adenine dinucleotide, 0.07 to 7 percent of extract, 2 to 15 percent of vitamin, 3 to 10 percent of edible essence and hydroxyl compound are added to 100 percent.
In some preferred embodiments, the anti-enzyme active is selected from one or more of red wine powder, niacinamide, pomegranate (Punica grantum) fruit extract, yeast powder, N-acetylneuraminic acid, epicatechin gallate; preferably, the substance inhibiting enzymatic activity is N-acetylneuraminic acid.
In some preferred embodiments, the hyaluronic acid is selected from one or more of high molecular weight hyaluronic acid, medium molecular weight hyaluronic acid, low molecular weight hyaluronic acid, ultra-low molecular weight hyaluronic acid, oligomeric hyaluronic acid; preferably, the hyaluronic acid is an oligomeric hyaluronic acid.
In some preferred embodiments, the oligomeric hyaluronic acid has a molecular weight of 500-3000 Da; preferably, the oligomeric hyaluronic acid has a molecular weight of 766.6Da.
In some preferred embodiments, the calcium sodium phosphosilicate component comprises SiO 2 ，Na 2 O，CaO，P 2 O 5 。
In some preferred embodiments, the specific surface area of the calcium sodium phosphosilicate is 350 to 400m 2 G, the D50 particle size is less than or equal to 20 mu m; preferably, the specific surface area of the calcium sodium phosphosilicate is 3790m 2 The D50 particle size is 5 μm per g.
In some preferred embodiments, the extract is selected from one or more of jujube (Fructus Jujubae) extract, silybum marianum (Silybummarianum l.) extract, roselle (hibiscus sabdariffa l.) extract, emblica officinalis (Phyllanthus emblica l.) extract, rice bran (Oryza sativa l.) extract, hovenia acerba lindl extract, artichoke (Cynara scolymus) extract, pueraria lobata (wilerld.) Ohwi) extract; preferably, the extracts are silybum marianum extract and rice bran extract.
In some preferred embodiments, the mass ratio of the silybum marianum extract to the rice bran extract is (0.05-5): (0.02-3); preferably, the mass ratio of the silybum marianum extract to the rice bran extract is 0.08:0.05.
in some preferred embodiments, the rice bran extract is a rice bran fatty alkanol.
Most of alcohol in the body reacts with alcohol dehydrogenase in the liver first to generate acetaldehyde, which causes damage to human organs. The applicant adds the rice bran extract, in particular the rice bran fatty alkanol, so that the decomposition of ethanol in vivo can be effectively accelerated, and the alcohol content in blood can be reduced. Presumably, the rice bran fatty alcohol contains various higher fatty alcohols such as dioctadecyl fatty alcohol, triacontyl fatty alcohol and dotriacontal fatty alcohol, and the HMG-CoA reductase can be regulated to significantly accelerate the metabolism and consumption of acetaldehyde generated in vivo, reduce the acetaldehyde concentration, and further prevent alcoholic liver. Simultaneously, the contents of cholesterol and triglyceride can be reduced, the reaction flexibility, the strain capacity and the physical strength are improved, and the damage caused by drunkenness is improved.
However, acetaldehyde consumption and metabolism are mainly carried out in the liver, and the working pressure of the liver is increased, so that dryness is damaged. The applicant finds that the silybum marianum extract added into the system can play a role in protecting the liver after drinking. Presumably, the silybum marianum extract contains many acids such as fumaric acid, silybin, myristic acid, palmitic acid and the like, so that a protective film can be formed to prevent toxic substances from invading the liver, promote the generation of enzymes and structural proteins, mediate the synthesis of hepatocyte DNA, stimulate the generation of new hepatocytes, repair the membrane structure and improve the liver function and the recovery capability thereof under the synergistic effect of calcium sodium phosphosilicate and other components. In addition, the compound can also provide strong antioxidation, protect the normal fluidity of liver cell membranes by resisting lipid peroxidation, inhibit cell membrane ion channels, promote the oxidation reaction of cholesterol and further reduce blood fat. The applicant has unexpectedly found that when the mass ratio of silybum marianum extract to rice bran extract is 0.081: when 0.05 hour, the atomized stock solution has optimal hangover alleviating speed and liver protecting effect.
In some preferred embodiments, the vitamin is selected from one or more of vitamin a, vitamin B, vitamin C, vitamin E; preferably, the vitamins are vitamin B and vitamin C.
In some preferred embodiments, the mass ratio of vitamin B to vitamin C is (2 to 12): (0.5-5); preferably, the mass ratio of the vitamin B to the vitamin C is 5:2.
in some preferred embodiments, the vitamin B is selected from one or more of vitamin B1, vitamin B6, vitamin B12; preferably, the vitamin B is vitamin B12.
The applicant finds that the vitamin C added into the system can enhance the resistance of liver cells, promote the regeneration of the liver cells and the synthesis of hepatic glycogen, and promote the metabolic discharge of cholesterol, so that the effects of detoxifying, eliminating jaundice, reducing transaminase and recovering liver function are achieved. Meanwhile, a large amount of free radicals generated by alcohol toxin can be clearly treated, and the free radicals are matched with the silybum marianum extract to play a role in further increasing the regeneration of liver cells and enhancing the repair capacity of the liver. The vitamin B12 absorption function of a human body can be promoted, the combined action slows down the reaction that ethanol is decomposed into acetaldehyde under the renting of alcohol dehydrogenase, the generation of the acetaldehyde is fundamentally reduced, the demand on the acetaldehyde dehydrogenase is further reduced, the ethanol in the body can be successfully converted into acetic acid and then is continuously converted into water and nitrogen dioxide to be discharged out of the body, the decomposition of the ethanol is further accelerated, and the liver protection function is realized.
In some preferred embodiments, the hydroxyl compound is selected from one or more of 1, 2-propanediol, triethylene glycol, glycerol, tetraethylene glycol, triethylene glycol, ethanol, butanediol; preferably, the hydroxyl compounds are 1, 2-propanediol and glycerol.
In some preferred embodiments, the mass ratio of 1, 2-propanediol to glycerol is (3-5): (4-7); preferably, the mass ratio of the 1, 2-propylene glycol to the glycerol is 3.2:5.5.
in some preferred embodiments, the glycerol is selected from one or more of synthetic glycerol, refined glycerol, hydrolyzed glycerol; preferably, the glycerol is hydrolyzed glycerol; further preferably, the content of chloride in the hydrolyzed glycerol is less than or equal to 10mg/kg, and the saponification equivalent weight is less than or equal to 0.64mmol/100g; still more preferably, the hydrolyzed glycerin has a chloride content of 3.79mg/kg and a saponification equivalent of 0.22mmol/100g.
The extract has multiple effects, but the substance composition is complex, and the solubility in the system can cause the stability of the obtained atomized liquid. The applicant has found that when the hydroxy compound is a mixture of 1, 2-propanediol and glycerol, the solubility of the extract is increased. Particularly, when the glycerol is hydrolyzed glycerol, the purity is moderate, impurities and precipitates cannot be generated in the system, the components in the system can be fully dissolved, a uniform and stable system is formed, and the obtained atomized stock solution has excellent stability and mist saturation. Meanwhile, the synergistic effect of the components such as hyaluronic acid and the like in the system can effectively avoid the problems of irritation, dry mouth, even rash and the like caused by the 1, 2-propylene glycol in the using process, so that the taste and the stability of the atomized raw material are greatly improved.
The second aspect of the invention provides a preparation method of an alcohol-relieving and liver-protecting atomized liquid containing an extract, which comprises the following steps:
(1) Adding the anti-enzyme active substance, hyaluronic acid, vitamin and edible essence into the hydroxyl compound, stirring and mixing;
(2) Continuously adding sodium calcium phosphosilicate, beta-nicotinamide adenine dinucleotide and the extract, and continuously stirring to obtain the final product.
Compared with the prior art, the invention has the following beneficial effects:
(1) According to the application, the prepared atomized stock solution can effectively reduce the liver transaminase and cholesterol level, accelerate alcohol metabolism, rapidly decompose ethanol in vivo, prevent drunkenness and subsequent discomfort to a certain extent, reduce the alcohol content in blood and simultaneously protect liver health by adding the anti-enzyme active substance, hyaluronic acid, calcium sodium phosphosilicate, beta-nicotinamide adenine dinucleotide, the extract, vitamins and edible essence; meanwhile, the regeneration capability of the liver-protecting tea can be enhanced, the liver can be protected from being damaged by hepatotoxicity, and the effect of relieving alcoholism and protecting the liver is obvious.
(2) The 1, 2-propylene glycol and the glycerol are selected to ensure that the atomized stock solution has strong stability, the decomposition of effective components can not occur within half a year under the acceleration condition, and meanwhile, the mist saturation is high, and the problems of blockage and the like can not be caused. The functional atomization stock solution is safe in formula, free of toxic and side effects, good in taste, high in taste saturation, free of the problem of dry mouth and throat irritation and convenient to use.
Detailed Description
Example 1:
1. an alcohol-relieving and liver-protecting atomized liquid containing an extract is prepared from the following raw materials: the weight percentage is as follows:
0.2% of anti-enzyme active substance, 0.3% of hyaluronic acid, 4% of calcium sodium phosphosilicate, 0.1% of beta-nicotinamide adenine dinucleotide, 0.231% of extract, 5% of vitamin, 3% of edible essence and hydroxyl compound are added to 100%.
The substance for inhibiting the enzyme activity is N-acetylneuraminic acid.
The hyaluronic acid is oligomeric hyaluronic acid.
The oligomeric hyaluronic acid has a molecular weight of 766.6Da (available from Jijie Biotech, inc. of Hebei).
The calcium sodium phosphosilicate comprises SiO 2 ，Na 2 O，CaO，P 2 O 5 。
The specific surface area of the calcium sodium phosphosilicate is 3790m 2 (ii)/g, D50 particle size 5 μm (available from Beijing Happy Probiotics high tech Co., ltd.).
The extract is herba Silybi Mariani (Silybum marianum L.) extract (from Bao Ji Liu Dian Yun Biotech Co., ltd.) and testa oryzae (Oryza sativa L.).
The mass ratio of the silybum marianum extract to the rice bran extract is 0.081:0.15.
the rice bran extract is rice bran fatty alkanol.
The vitamins are vitamin B and vitamin C.
The mass ratio of the vitamin B to the vitamin C is 5:2.
the vitamin B is vitamin B12.
The hydroxyl compounds are 1, 2-propanediol and glycerol.
The mass ratio of the 1, 2-propylene glycol to the glycerol is 3.2:5.5.
the glycerol is hydrolyzed glycerol; the hydrolyzed glycerol had a chloride content of 3.79mg/kg and a saponification equivalent of 0.22mmol/100g (available from Yangzhou Feiyang chemical Co., ltd.).
2. A preparation method of an alcohol-relieving and liver-protecting atomized liquid containing an extract comprises the following steps:
(1) Adding the anti-enzyme active substance, hyaluronic acid, vitamin and edible essence into the hydroxyl compound, stirring and mixing;
(2) Continuously adding sodium calcium phosphosilicate, beta-nicotinamide adenine dinucleotide and the extract, and continuously stirring to obtain the final product.
Example 2:
1. an anti-alcohol and liver-protecting atomized liquid containing an extract is different from the atomized liquid in example 1 in that:
the preparation raw materials comprise: the weight percentage is as follows:
0.05% of anti-enzyme active substance, 0.4% of hyaluronic acid, 3% of calcium sodium phosphosilicate, 0.15% of beta-nicotinamide adenine dinucleotide, 0.275% of extract, 4% of vitamin, 3% of edible essence and hydroxyl compound are added to 100%.
The mass ratio of the silybum marianum (Silybum marianum L.) extract to the rice bran (Oryza sativa L.) extract is 0.075:0.2.
2. a preparation method of an anti-hangover and hepatoprotective atomized liquid containing the extract is the same as that in example 1.
Comparative example 1:
1. an anti-alcohol and liver-protecting atomized liquid containing an extract is different from the atomized liquid in example 1 in that:
the extract is radix Puerariae (Pueraria lobata (Willd.) Ohwi) extract (from Hibiscus limited) and testa oryzae extract.
2. A preparation method of an anti-hangover and hepatoprotective atomized liquid containing the extract is the same as that in example 1.
Comparative example 2:
1. an anti-alcohol and liver-protecting atomized liquid containing an extract is different from the atomized liquid in example 1 in that:
the mass ratio of the vitamin B to the vitamin C is 1:3.
2. a method for preparing an anti-hangover and hepatoprotective atomized liquid containing the extract is the same as in example 1.
Comparative example 3:
1. an anti-alcohol and liver-protecting atomized liquid containing an extract is different from the atomized liquid in example 1 in that:
the glycerol is refined glycerol (available from Shanghai Liyue International trade company, inc.).
2. A method for preparing an anti-hangover and hepatoprotective atomized liquid containing the extract is the same as in example 1.
And (3) performance testing:
1. and (3) testing physical and chemical properties: the samples obtained in example 1 were tested according to the standard Q/GHJK 004-2021 atomized liquid for relieving or neutralizing the effect of alcohol and protecting the liver containing the extract;
table 1 results of physical and chemical properties test of atomized stock solution obtained in example
2. And (3) component testing:
table 2 test results of contents of components of atomized stock solution obtained in example 1
| Detecting items | Detection method | Detection limit | The result of the detection |
| Silymarin | Q/GHJK 004-2021 | / | 815.0mg/kg |
| Nicotine | Q/GHJK 004-2021 | 0.001％ | Not detected out |
| Diethylene glycol | GB/T 21842-2008 | 30mg/kg | Not detected out |
3. And (3) stability testing: the atomized stock solutions obtained in examples and comparative examples were allowed to stand at 40 ℃ and 75% relative humidity for 3 months and 6 months, respectively, to determine their stability, and the test items included color, appearance, and silymarin content.
Table 3 stability test results of the atomized stock solutions obtained in examples and comparative examples
Claims (10)
1. The alcohol-dispelling and liver-protecting atomized liquid containing the extract is characterized by comprising the following preparation raw materials in parts by weight: the weight percentage is as follows:
0.05 to 1 percent of enzyme-resistant active substance, 0.05 to 6 percent of hyaluronic acid, 1 to 12 percent of calcium sodium phosphosilicate, 0.05 to 3 percent of beta-nicotinamide adenine dinucleotide, 0.07 to 7 percent of extract, 2 to 15 percent of vitamin, 3 to 10 percent of edible essence and hydroxyl compound are added to 100 percent.
2. The extract-containing atomized liquid for relieving or neutralizing the effect of alcohol and protecting liver according to claim 1, wherein the hyaluronic acid is one or more selected from the group consisting of high molecular weight hyaluronic acid, medium molecular weight hyaluronic acid, low molecular weight hyaluronic acid, ultra-low molecular weight hyaluronic acid and oligomeric hyaluronic acid.
3. The extract-containing anti-hangover and liver-protecting aerosolized liquid of claim 1 or 2, wherein the hyaluronic acid is selected from an oligomeric hyaluronic acid.
4. The extract-containing atomized liquid for relieving alcoholism and protecting liver as set forth in claim 1, wherein the calcium sodium phosphosilicate comprises SiO 2 ，Na 2 O，CaO，P 2 O 5 。
5. The extract-containing atomized liquid for relieving or neutralizing the effect of alcohol and protecting liver as claimed in claim 1 or 4, wherein the specific surface area of the calcium sodium phosphosilicate is 350-400 m 2 The grain diameter of D50 is less than or equal to 20 mu m.
6. The extract-containing anti-alcohol liver-protecting atomized liquid as claimed in claim 1, wherein the extract is one or more selected from jujube extract, silybum marianum extract, roselle extract, emblic leafflower fruit extract, rice bran extract, hovenia dulcis thunb extract, artichoke extract and pueraria lobata extract.
7. The extract-containing anti-alcohol and liver-protecting atomized liquid as claimed in claim 6, wherein the extract is Silybum marianum extract and rice bran extract.
8. The extract-containing atomized liquid for relieving alcoholism and protecting liver as claimed in claim 1, wherein the vitamin is one or more selected from vitamin A, vitamin B, vitamin C and vitamin E.
9. The extract-containing atomized liquid for relieving or neutralizing the effect of alcohol and protecting liver of claim 1, wherein the hydroxyl compound is one or more selected from the group consisting of 1, 2-propanediol, triethylene glycol, glycerol, tetraethylene glycol, triethylene glycol, ethanol and butylene glycol.
10. A method for preparing the atomized liquid containing the extract for relieving alcoholism and protecting liver as claimed in claim 1, which comprises the following steps:
(1) Adding the anti-enzyme active substance, hyaluronic acid, vitamin and edible essence into the hydroxyl compound, stirring and mixing;
(2) Continuously adding sodium calcium phosphosilicate, beta-nicotinamide adenine dinucleotide and the extract, and continuously stirring to obtain the final product.
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Citations (4)
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| CN102499411A (en) * | 2011-11-03 | 2012-06-20 | 南昌大学 | Liver nourishing/protecting beverage and preparation method thereof |
| CN104645204A (en) * | 2015-03-03 | 2015-05-27 | 华健 | Electronic atomized liquid having functions of detoxifying and de-inebriating and preparation method thereof |
| CN105394808A (en) * | 2015-12-17 | 2016-03-16 | 立场电子科技发展（上海）有限公司 | Atomization liquid for electronic cigarette |
| CN112535290A (en) * | 2020-12-31 | 2021-03-23 | 张学记 | Composition capable of rapidly dispelling effects of alcohol and preparation method and device thereof |
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2022
- 2022-04-28 CN CN202210462542.5A patent/CN115887585A/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102499411A (en) * | 2011-11-03 | 2012-06-20 | 南昌大学 | Liver nourishing/protecting beverage and preparation method thereof |
| CN104645204A (en) * | 2015-03-03 | 2015-05-27 | 华健 | Electronic atomized liquid having functions of detoxifying and de-inebriating and preparation method thereof |
| CN105394808A (en) * | 2015-12-17 | 2016-03-16 | 立场电子科技发展（上海）有限公司 | Atomization liquid for electronic cigarette |
| CN112535290A (en) * | 2020-12-31 | 2021-03-23 | 张学记 | Composition capable of rapidly dispelling effects of alcohol and preparation method and device thereof |
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| Title |
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