CN115887259A - Anti-inflammatory and anti-aging composition, anti-inflammatory and anti-aging essence and preparation method thereof - Google Patents
Anti-inflammatory and anti-aging composition, anti-inflammatory and anti-aging essence and preparation method thereof Download PDFInfo
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Abstract
The application discloses an anti-inflammatory and anti-aging composition, an anti-inflammatory and anti-aging essence and a preparation method thereof. The anti-inflammatory and anti-aging composition comprises the following components in parts by weight: lactobacillus fermentation lysate, 10 parts; 10-150 parts of a schizosaccharomyces cerevisiae fermentation product lysate; 2-30 parts of at least one of hyaluronic acid, hyaluronate and hyaluronic acid derivatives; 0.1-3 parts of tocopherol acetate; 0.2-3 parts of bisabolol. The five ingredients are compounded and acted together, and are matched with each other to play a synergistic or synergistic role, so that the polypeptide, the protein and the like generated in the deep layer of the skin are promoted to keep the skin elasticity and realize anti-aging; the anti-inflammatory and anti-aging skin care product has comprehensive effects in anti-inflammation, repair, soothing, moisturizing and the like, is accurately positioned and repaired from deep skin cells, reduces inflammation, promotes skin renewal and skin barrier recovery, and achieves the anti-inflammatory and anti-aging effects of the skin; the substances have synergistic effect and the effect is far better than that of the single substance.
Description
Technical Field
The application belongs to the technical field of daily cosmetics, and particularly relates to an anti-inflammatory and anti-aging composition, an anti-inflammatory and anti-aging essence lotion and a preparation method thereof.
Background
Skin aging refers to the deterioration of the protective ability and the regulating ability of skin to the body, the failure to adapt to the change of internal and external environments, the appearance overall conditions such as color, shape and the like are changed, a series of skin problems such as fragile skin barrier, rough and long lines, water and oil imbalance, insufficient automatic skin repair at night, looseness and droop and the like are often presented, and the health, the appearance and the self-confidence of the skin are seriously influenced.
Inflammation is a local reaction that occurs at the site of injury to initiate the removal of pathogen invades and damages tissue. Manifested by external symptoms such as erythema, edema, fever, and pain. In normal humans, the inflammatory response removes the external source of infection, regenerates damaged tissues, and restores body function, but it also severely affects skin health and appearance.
However, the existing anti-inflammatory and anti-aging cosmetics have poor effects and complex formula.
Disclosure of Invention
In view of this, the present application provides an anti-inflammatory and anti-aging composition, an anti-inflammatory and anti-aging essence, and a preparation method thereof, and aims to provide a composition having good anti-inflammatory and anti-aging effects for cosmetics.
In a first aspect, the embodiments of the present application provide an anti-inflammatory and anti-aging composition, which comprises the following components in parts by weight:
lactobacillus fermentation lysate, 10 parts;
10-150 parts of a schizosaccharomyces cerevisiae fermentation product lysate;
2-30 parts of at least one of hyaluronic acid, hyaluronate and hyaluronic acid derivatives;
0.1-3 parts of tocopherol acetate;
0.2-3 parts of bisabolol.
According to an embodiment of one aspect of the application, the anti-inflammatory and anti-aging composition comprises the following components in parts by weight:
lactobacillus fermentation lysate, 10 parts;
20-100 parts of a schizosaccharomyces cerevisiae fermentation product lysate;
5-20 parts of at least one of hyaluronic acid, hyaluronate and hyaluronic acid derivatives;
1-2 parts of tocopherol acetate;
1-2 parts of bisabolol.
According to an embodiment of one aspect of the application, the anti-inflammatory and anti-ageing composition comprises the following components in parts by weight:
lactobacillus fermentation lysate, 10 parts;
20-50 parts of a schizosaccharomyces cerevisiae fermentation product lysate;
5-10 parts of at least one of hyaluronic acid, hyaluronate and hyaluronic acid derivatives;
1-1.5 parts of tocopherol acetate;
1-1.5 parts of bisabolol.
In a second aspect, the application provides an anti-inflammatory and anti-aging essence lotion, which comprises the following components in percentage by mass:
lactobacillus fermentation lysate, 1% -5%;
(ii) a secondary split yeast fermentation product lysate, 5% -15%;
1% -3% of at least one of hyaluronic acid, hyaluronate and hyaluronic acid derivatives;
0.05 to 0.3 percent of tocopherol acetate;
0.1% -0.3% of bisabolol;
0-8% of humectant;
0-8% of preservative;
0.1 to 8 percent of thickening agent;
0-3% of pH regulator;
0-5% of metal chelating agent;
0.1 to 1 percent of vegetable oil;
0.2 to 8 percent of emulsifier;
92.4 to 99.85 percent of water.
According to an aspect of the application, the anti-inflammatory and anti-aging essence comprises the following components in percentage by mass:
lactobacillus fermentation lysate, 1% -5%;
(ii) a secondary split yeast fermentation product lysate, 5% -15%;
1% -3% of at least one of hyaluronic acid, hyaluronate and hyaluronic acid derivative;
0.1% -0.3% of tocopherol acetate;
0.1% -0.3% of bisabolol;
0.5 to 8 percent of humectant;
0.5 to 8 percent of preservative;
0.1 to 8 percent of thickening agent;
0.1 to 3 percent of pH regulator
0.1% -5% of metal chelating agent;
0.1 to 1 percent of vegetable oil;
0.2 to 8 percent of emulsifier;
93.3 to 99.85 percent of water.
According to an embodiment of one aspect of the application, the humectant is selected from glycerin, butylene glycol, 1, 3-propanediol, 1, 2-pentanediol, octaethylene glycol, or a combination thereof.
According to an embodiment of one aspect of the application, the preservative is selected from phenoxyethanol, p-hydroxyacetophenone, 1, 2-pentanediol, 1, 2-hexanediol, caprylyl glycol, ethylhexyl glycerol, benzoic acid, sodium benzoate, caprylyl hydroxamic acid, or a combination thereof.
According to an embodiment of one aspect of the application, the thickener is selected from carbomers, acrylic polymers cross-linked with C10-C30 alkanol acrylates, xanthan gum or combinations thereof.
According to an embodiment of one aspect of the present application, the pH adjusting agent is selected from arginine, tromethamine, sodium hydroxide aqueous emulsion or a combination thereof; and 5% of sodium hydroxide water emulsion can be selected.
According to an embodiment of one aspect of the application, the metal chelating agent is selected from disodium ethylenediaminetetraacetate, EDTA, hydroxyethane diphosphonic acid or a combination thereof.
According to an embodiment of one aspect of the present application, the vegetable fat is selected from the group consisting of jojoba oil, sunflower seed oil, castor oil, coconut oil, grape seed oil, shea butter, meadowfoam seed oil, macadamia nut oil, olive oil, palm oil, squalane, cocoa butter, jojoba fat, glycolipids, octyldodecanol, caprylic/capric triglyceride, coco-caprylic/capric triglyceride, oleic acid, linoleic acid, linolenic acid polyglycerides, and dioctyldodecanol dilinoleate or a combination thereof.
According to an embodiment of one aspect of the present application, the emulsifier is selected from the group consisting of oleyl polyether-3 phosphate, oleyl polyether-3, oleyl polyether-5 or combinations thereof.
According to an embodiment of one aspect of the application, the water is selected from deionized water, a yeast secondary fission fermentation filtrate, or a combination thereof.
In a third aspect, the present application provides a method for preparing the anti-inflammatory and anti-aging essence of the second aspect, comprising:
preparing an aqueous phase solution: mixing a humectant, a preservative, a thickener, and a metal chelator;
mixing at least one of aqueous phase solution, lactobacillus fermentation lysate, yeast fermentation lysate, hyaluronic acid, hyaluronate, hyaluronic acid derivative, tocopherol acetate, vegetable oil and fat, and emulsifier, homogenizing, and emulsifying to obtain antiinflammatory and antiaging essence lotion.
According to an embodiment of one aspect of the application, preparing the aqueous phase solution comprises: the humectant, the preservative, the thickener, and the metal chelator are mixed under heating to mix the solutions uniformly.
In a fourth aspect, the present application provides an anti-inflammatory anti-ageing cosmetic or pharmaceutical composition comprising: an anti-inflammatory and anti-ageing composition according to the first aspect and a cosmetically acceptable adjuvant.
Compared with the prior art, the application has at least the following beneficial effects:
according to the anti-inflammatory and anti-aging composition, 10 parts of lactobacillus fermentation lysate, 10-150 parts of yeast fermentation lysate, 2-30 parts of at least one of hyaluronic acid, hyaluronate and hyaluronic acid derivatives, 0.2-3 parts of tocopherol acetate and 0.2-3 parts of bisabolol are compounded and combined to play a synergistic effect, so that the polypeptide, protein and the like generated in the deep layer of the skin are promoted to keep the elasticity of the skin and realize anti-aging; the anti-inflammatory and anti-aging skin care product has comprehensive effects of resisting inflammation, repairing, relieving, moisturizing and the like, is accurately positioned and repaired from deep skin cells, reduces inflammation, promotes skin renewal and skin barrier recovery, and achieves the effects of resisting inflammation and aging of the skin. The substances have synergistic effect and far better effect than the single substances.
Drawings
Figure 1 shows the collagen status of the skin when the product is not in use;
fig. 2 shows the collagen status after 28 days using the anti-inflammatory and anti-aging essence of the present application.
Detailed Description
In order to make the application purpose, technical solution and beneficial technical effects of the present application clearer, the present application is further described in detail with reference to the following embodiments. It should be understood that the embodiments described in this specification are only for the purpose of explaining the present application and are not intended to limit the present application.
For the sake of brevity, only a few numerical ranges are explicitly disclosed herein. However, any lower limit may be combined with any upper limit to form ranges not explicitly recited; and any lower limit may be combined with any other lower limit to form a range not explicitly recited, and similarly any upper limit may be combined with any other upper limit to form a range not explicitly recited. Also, although not explicitly recited, each point or individual value between endpoints of a range is encompassed within the range. Thus, each point or individual value can form a range not explicitly recited as its own lower or upper limit in combination with any other point or individual value or in combination with other lower or upper limits.
In the description of the present application, it is to be noted that "more" and "below" are intended to include the present numbers, and "more" of "one or more" means two or more, unless otherwise specified.
The above summary of the present application is not intended to describe each disclosed embodiment or every implementation of the present application. The following description more particularly exemplifies illustrative embodiments. At various points throughout this application, guidance is provided through a list of embodiments that can be used in various combinations. In each instance, the list is merely a representative group and should not be construed as exhaustive.
People are increasingly looking at skin problems, and skin aging is an important skin problem, and the skin aging causes the reduction of the protection capability and the regulation capability of the skin to the organism, cannot adapt to the change of internal and external environments, has the change of integral appearance conditions such as color, shape and the like, and is often expressed by the reduction or disappearance of the skin elasticity, the skin relaxation, the increase of wrinkles, the dryness, the thinning, the easy desquamation, the pruritus, the dull complexion and no luster, and is accompanied with color spots and warts.
Inflammation is a local reaction that occurs at the site of injury to initiate the removal of pathogen invades and damages tissue. Despite its positive effects, it seriously affects skin health, is manifested as a complex series of physiological reactions such as activation of enzymes, secretion of inflammatory mediators, body fluid penetration, cell movement, and causing damage associated with various inflammatory mediators and immune cells in local blood vessels and body fluids, and as external symptoms such as erythema, edema, fever, and pain. And in some cases, cause diseases such as cancer.
In the related products, complex ingredients are required to be added to improve the aging of the skin, but the related products often act on the surface of the skin and have limited effects.
Through the research of the inventor, the specific lysate can be provided, so that the components of the lysate act synergistically, repair is accelerated, the damaged part is accurately positioned under the combined action of multiple channel components, the skin is repaired, the generation of inflammation is reduced, the self synthesis and differentiation of the skin are guided, the skin is guided to generate key components related to skin anti-aging, the aggregation of keratinocytes is improved, the generation of antibacterial peptide is increased, and the skin renewal and skin barrier recovery are promoted.
Anti-inflammatory and anti-aging composition
The embodiment of the application provides an anti-inflammatory and anti-ageing composition in a first aspect, which comprises the following components in parts by weight:
lactobacillus fermentation lysate, 10 parts;
10-150 parts of a schizosaccharomyces cerevisiae fermentation product lysate;
2-30 parts of at least one of hyaluronic acid, hyaluronate and hyaluronic acid derivatives;
0.1-3 parts of tocopherol acetate;
0.2-3 parts of bisabolol.
According to the embodiment of the application, the lactobacillus fermentation lysate comprises thalli and all active ingredients synthesized in the fermentation process, contains peptidoglycan, teichoic acid, protein, phospholipid, sterol, fatty acid, various enzymes, peptide, amino acid, nucleotide, extracellular polysaccharide and the like, can provide rich nutrition for skin, wherein various peptides, amino acid and nucleotide have good anti-aging effect, and can be utilized by the skin for further anti-aging under the stimulation of the components such as the lysate of the yeast fermentation product.
According to the present embodiment, the schizosaccharomyces cerevisiae fermentation product lysate can be a metabolite, a cytoplasmic fraction, a cell wall component, and a polysaccharide complex obtained by culturing, inactivating, and decomposing bifidobacterium. The composition has strong anti-immunosuppression activity, can promote the production of tripeptide-1 copper and collagen under the combined action of other components, thereby promoting DNA repair, effectively protecting skin from being damaged by ultraviolet rays, and preventing and resisting photoaging of epidermis and dermis. The dialytic yeast fermentation product sporolysate comprises small molecules such as vitamin B group, mineral substances, amino acids and the like which are beneficial to skin care, can strengthen the metabolism of stratum corneum, can capture free radicals, inhibits the peroxidation of lipid, and has the functions of whitening, resisting aging and nourishing skin. The part by weight of the schizosaccharomyces cerevisiae fermentation product lysate in the anti-inflammatory and anti-aging composition can be 10, 20, 30, 40, 50, 60, 70, 80, 90, 100, 110, 120, 130, 140, 150, and the like, and can also be any combination range of the above values.
According to the embodiment of the application, at least one of hyaluronic acid, hyaluronate and hyaluronic acid derivatives includes but is not limited to sodium hyaluronate, sodium hyaluronate cross-linked polymer (the polymerization degree can be 10-20), hyaluronic acid, acetylated hyaluronic acid and sodium acetylated hyaluronate. The above substance is an acidic mucopolysaccharide, and can be used in the anti-inflammatory and anti-aging composition, and has effects of keeping moisture, resisting inflammation, and promoting wound healing. Small hyaluronic acid molecules with number average molecular weight of 5000-10000 can improve fine lines, and large hyaluronic acid molecules with number average molecular weight of 500000-300000 can fill and improve facial contour, and can be used for repairing and resisting aging together. The weight portion of at least one of hyaluronic acid, hyaluronate, and hyaluronic acid derivative in the above anti-inflammatory and anti-aging composition may be 0.2, 0.3, 0.4, 0.5, 0.6, 0.7, 0.8, 0.9, 1.0, 1.1, 1.2, 1.3, 1.4, 1.5, 2.0, 2.2, 2.5, 2.8, 3.0, or any combination of the above values.
According to the embodiment of the application, the tocopherol acetate belongs to a derivative of vitamin E, has a good antioxidant effect, is an oil-soluble natural substance, has a good nourishing and moistening effect on skin, has good performance in moisturizing and maintaining connective tissues and protecting the skin from being damaged by ultraviolet rays, can make the skin feel soft and keep the skin moisture, promote wound healing, prevent inflammation, prevent skin roughness and chapping, improve black spots, prevent skin aging, enhance cell activity, has a good anti-aging effect, can help women delay aging and keep young. The weight parts of the tocopherol acetate in the anti-inflammatory and anti-aging composition can be 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 20, 22, 25, 28, 30 and the like, and can also be in any combination range of the above values.
According to the embodiment of the application, the bisabolol is nontoxic sesquiterpene alcohol and has antibacterial and anti-inflammatory effects, the bisabolol can reduce the release of leukotriene and interleukin-1, so that the tissue edema caused by chemical factors is relieved, the inflammation is relieved, the bisabolol also has the effects of resisting stimulation and repair, and the anti-aging effect is realized from the anti-inflammatory, relieving and repairing directions; the bisabolol has good stability and can be well integrated with skin. The weight portion of the bisabolol in the anti-inflammatory and anti-aging composition may be 0.2, 0.3, 0.4, 0.5, 0.6, 0.7, 0.8, 0.9, 1.0, 1.1, 1.2, 1.3, 1.4, 1.5, 2.0, 2.2, 2.5, 2.8, 3.0, etc., and may be any combination range of the above values.
According to the embodiment of the application, the lactobacillus fermentation lysate, the saccharomyces cerevisiae fermentation lysate, at least one of hyaluronic acid, hyaluronate, hyaluronic acid derivative, tocopherol acetate and bisabolol in parts by weight are compounded, so that the synergistic effect is achieved, the skin can be deeply acted, the collagen regeneration is promoted, the anti-inflammation effect is achieved, the skin barrier is repaired, the wrinkles are reduced, and the anti-inflammation and anti-aging effects are achieved from multiple directions. The anti-inflammatory and anti-aging effects can be further ensured by adjusting the content of each component.
In some embodiments, the anti-inflammatory and anti-aging composition comprises the following components in parts by weight:
lactobacillus fermentation lysate, 10 parts;
20-100 parts of a schizosaccharomyces cerevisiae fermentation product lysate;
5-20 parts of at least one of hyaluronic acid, hyaluronate and hyaluronic acid derivatives;
1-2 parts of tocopherol acetate;
1-2 parts of bisabolol.
In some embodiments, the anti-inflammatory and anti-aging composition comprises the following components in parts by weight:
lactobacillus fermentation lysate, 10 parts;
split yeast fermentation lysate, 20-50;
5-10 parts of at least one of hyaluronic acid, hyaluronate and hyaluronic acid derivatives;
1-1.5 parts of tocopherol acetate;
1-1.5 parts of bisabolol.
According to the embodiment of the application, the anti-inflammatory and anti-aging composition has the components in parts by weight, and the anti-inflammatory and anti-aging effects on the skin are further improved.
The second aspect of the embodiment of the application provides an anti-inflammatory and anti-aging essence which comprises the following components in percentage by mass:
lactobacillus fermentation lysate, 1% -5%;
(ii) a secondary split yeast fermentation lysate, 5% -15%;
1% -3% of at least one of hyaluronic acid, hyaluronate and hyaluronic acid derivative;
0.05 to 0.3 percent of tocopherol acetate;
0.1 to 0.3 percent of bisabolol;
0-8% of humectant;
0-8% of preservative;
0.1 to 8 percent of thickening agent;
0-5% of metal chelating agent;
0.1 to 1 percent of vegetable oil;
0.2 to 8 percent of emulsifier;
92.4 to 99.85 percent of water.
According to the embodiment of the application, the anti-inflammatory and anti-aging essence comprises 1% -5% of lactobacillus fermentation lysate, 5% -15% of yeast fermentation lysate, 1% -3% of at least one of hyaluronic acid, hyaluronate and hyaluronic acid derivative, 0.05% -0.3% of tocopherol acetate and 0.1% -0.3% of bisabolol which act together to achieve synergistic effect, reduce accumulation of free radicals, reduce glycosylation, maintain and enhance activity of collagen in skin and achieve good anti-inflammatory and anti-aging effects in multiple directions.
According to the embodiment of the present application, the mass fraction of the lactobacillus fermentation lysate in the anti-inflammatory and anti-aging essence lotion may be 1.0%, 1.1%, 1.2%, 1.3%, 1.4%, 1.5%, 2.0%, 2.2%, 2.5%, 2.8%, 3.0%, 3.5%, 4.0%, 4.5%, 5.0%, or the like, or any combination of the above values. The mass fraction of the schizosaccharomyces cerevisiae fermentation product lysate in the anti-inflammatory and anti-aging essence lotion can be 5%, 6%, 7%, 8%, 9%, 10.0%, 11%, 12%, 13%, 14%, 15%, and the like, and can be in any combination range of the above values. The mass fraction of at least one of hyaluronic acid, hyaluronate, and hyaluronic acid derivative in the anti-inflammatory and anti-aging essence may be 1.0%, 1.1%, 1.2%, 1.3%, 1.4%, 1.5%, 2.0%, 2.2%, 2.5%, 2.8%, 3.0%, or any combination of the above values. The mass fraction of the tocopherol acetate in the anti-inflammatory and anti-aging essence lotion can be 0.1%, 0.15%, 0.2%, 0.21%, 0.22%, 0.23%, 0.25%, 0.28%, 0.3% and the like, and can also be in any combination range of the above numerical values. The mass fraction of bisabolol in the anti-inflammatory and anti-aging essence lotion can be 0.1%, 0.15%, 0.2%, 0.21%, 0.22%, 0.23%, 0.25%, 0.28%, 0.3%, and the like, or any combination of the above values.
According to the embodiment of the application, the anti-inflammatory and anti-aging essence lotion is an oil-in-water type essence lotion, the viscosity of the anti-inflammatory and anti-aging essence lotion is controlled by the components such as vegetable oil and fat, a thickening agent and the like, the viscosity of the anti-aging essence lotion can be 15000-25000CPS, and the anti-aging essence lotion has a fresh skin-friendly feeling.
In some embodiments, the anti-inflammatory and anti-aging essence lotion further comprises 0.05% -0.15% of hydrogenated lecithin and caffeine depolymer. The above substances can promote the active components in the anti-inflammatory and anti-aging essence to penetrate into the skin, and realize anti-aging and anti-inflammatory effects through the deep action of the skin. For example, caffeine can promote the permeation and absorption of other active substances by external application, can effectively promote lipolysis, has the effects of tightening skin and removing wrinkles, is used for the anti-inflammatory and anti-aging essence, and also has the effects of resisting oxidation and inflammation and regulating skin moisture circulation.
In some embodiments, the anti-inflammatory and anti-aging essence comprises the following components in percentage by mass:
lactobacillus fermentation lysate, 1% -5%;
(ii) a secondary split yeast fermentation lysate, 5% -15%;
1% -3% of at least one of hyaluronic acid, hyaluronate and hyaluronic acid derivative;
0.1 to 0.3 percent of tocopherol acetate;
0.1% -0.3% of bisabolol;
0.5 to 8 percent of humectant;
0.5 to 8 percent of preservative;
0.1 to 8 percent of thickening agent;
0.1% -5% of metal chelating agent;
0.1 to 1 percent of vegetable oil;
0.2 to 8 percent of emulsifier;
93.3 to 99.85 percent of water.
In some embodiments, the humectant is selected from glycerin, butylene glycol, 1, 3-propanediol, 1, 2-pentanediol, octaethylene glycol, or a combination thereof. The humectant can further improve the moisture retention of deep skin and realize long-acting moisture retention.
In some embodiments, the preservative is selected from phenoxyethanol, p-hydroxyacetophenone, 1, 2-pentanediol, 1, 2-hexanediol, caprylyl glycol, ethylhexylglycerin, benzoic acid, sodium benzoate, caprylhydroxamic acid, or combinations thereof. The preservative can be well compatible with other substances, and the shelf life of the anti-inflammatory and anti-aging essence can be prolonged and the shelf life of the essence can be prolonged by adding the preservative.
In some embodiments, the thickening agent is selected from carbomers, acrylic polymers crosslinked with C10-C30 alkanol acrylate, xanthan gum, or combinations thereof.
According to the embodiment of the application, the thickening agent has important effects on thickening, stability and rheological property of the anti-inflammatory and anti-aging essence lotion; by using the thickener in the above weight ratio, it is possible to give it a good consistency, as well as excellent spreadability and spread.
In some embodiments, the pH adjusting agent is selected from arginine, tromethamine, sodium hydroxide aqueous emulsion, or combinations thereof; and 5% of sodium hydroxide water emulsion can be selected. The pH regulator can regulate pH of the anti-inflammatory and anti-aging essence lotion, so that the essence lotion can better act on skin and avoid irritation. In addition, tromethamine acts on skin and is beneficial to healing and repairing damaged tissues.
In some embodiments, the vegetable fat is selected from jojoba oil, sunflower seed oil, castor oil, coconut oil, grape seed oil, shea butter, meadowfoam seed oil, macadamia nut oil, olive oil, palm oil, squalane, cocoa butter, jojoba fat, glycolipids, octyldodecanol, caprylic capric triglyceride, coco-caprylic capric triglyceride, oleic acid, linoleic acid, linolenic acid polyglycerides, and dioctyldodecanol dilinoleate, or combinations thereof.
According to the embodiment of the present application, the vegetable oil or fat has excellent safety, moisturizing property, fluidity and ductility, and ensures the moisturizing effect. When skin cracks, the grape seed oil, the coconut oil and the sunflower seed oil also have an antioxidant effect, can accelerate the skin crack repairing effect, and can realize wrinkle resistance and inflammation resistance from the moistening and repairing directions. The content of vegetable oil and fat in the anti-inflammatory and antiaging essence lotion is 0.1%, 0.15%, 0.2%, 0.21%, 0.22%, 0.23%, 0.25%, 0.28%, 0.3%, 0.4%, 0.5%, 0.6%, 0.7%, 0.8%, 0.9%, 1.0% by weight
In some embodiments, the emulsifier is selected from oleyl polyether-3 phosphate, oleyl polyether-3, oleyl polyether-5, or a combination thereof. The emulsifier can provide excellent emulsifying effect, can be quickly emulsified when meeting water, is easy to wash, can be dispersed in water to form an oil-in-water emulsion with strong fluidity, is fresh and comfortable after makeup removal, and has no greasy feeling.
In some embodiments, the metal chelating agent is selected from disodium ethylenediaminetetraacetate, EDTA, hydroxyethane diphosphonic acid, or combinations thereof. The metal chelating agent can remove trace impurities in each component and provide the action effect, and EDTA is ethylenediamine tetraacetic acid.
In some embodiments, the water is selected from deionized water, a yeast secondary fermentation filtrate, or a combination thereof. The deionized water can avoid introducing impurities; the secondary split yeast fermentation filtrate contains micromolecular polypeptides such as amino acid organic acid cytoplasm and the like, and is rich in vitamin B group; can resist and repair the barrier function of the damaged skin to strengthen the skin from the source, achieves the effect of brightening, and can strengthen the metabolism of the cuticle, arouse the elasticity and the vitality of the skin and enhance the anti-aging effect.
Preparation method of anti-inflammatory and anti-aging essence
In a third aspect, the present application provides a method for preparing the anti-inflammatory and anti-aging essence of the second aspect, comprising:
preparing an aqueous phase solution: mixing a humectant, a preservative, a thickener, and a metal chelator;
mixing at least one of aqueous phase solution, lactobacillus fermentation lysate, yeast fermentation lysate, hyaluronic acid, hyaluronate, hyaluronic acid derivative, tocopherol acetate, vegetable oil and fat, and emulsifier, homogenizing, and emulsifying to obtain antiinflammatory and antiaging essence lotion.
In some embodiments, preparing the aqueous phase solution comprises: the humectant, the preservative, the thickener, and the metal chelator are mixed under heating to mix the solutions uniformly.
In some embodiments, the humectant, preservative, thickener, and metal chelator are mixed under heating to 50-80 ℃ to mix the solutions evenly.
In one embodiment, the anti-inflammatory and anti-aging essence is obtained by mixing at least one of an aqueous phase solution, a lactobacillus fermentation lysate, a yeast dehiscence lysate, hyaluronic acid, a hyaluronate salt, a hyaluronic acid derivative, tocopherol acetate, vegetable oil and an emulsifier, homogenizing and emulsifying, and adding a pH regulator.
Anti-inflammatory and anti-aging cosmetic or pharmaceutical composition
In a fourth aspect, the present application provides an anti-inflammatory anti-ageing cosmetic or pharmaceutical composition comprising: an anti-inflammatory and anti-ageing composition according to the first aspect and a cosmetically acceptable adjuvant.
The cosmetic or pharmaceutical composition of the present application may be added with various desired cosmetic or pharmaceutically acceptable excipients according to various formulation forms of the composition. For example, when the composition of the present application is prepared as a liquid, the excipient may be selected from water, physiological saline, and the like; when the composition of the present invention is prepared into a gel, the excipient may be selected from cellulose derivatives, starch, gelatin, agar, polysaccharides, and the like; when the composition of the present application is prepared as a cream, the excipient may be selected from glycerin, vaseline, paraffin, etc.; when the composition of the present application is prepared as a foam, the excipient may be selected from hydroxypropyl methylcellulose, sodium lauryl sulfate polyethylene glycol, sodium fatty alcohol-polyoxyethylene ether sulfonate, and the like; when the compositions of the present application are prepared as a patch, the excipient may be selected from cellulose derivatives, starch, gelatin, agar, polysaccharides, and the like.
According to the embodiment of the application, the cosmetic or pharmaceutical composition is suitable for cleaning, washing and protecting skin products such as aqua products, emulsified products, oil products and the like, and can also be used in beauty products such as essences, facial masks and the like, such as ointments, foundation make-up and the like.
Examples
The present disclosure is more particularly described in the following examples that are intended as illustrations only, since various modifications and changes within the scope of the present disclosure will be apparent to those skilled in the art. Unless otherwise indicated, all parts, percentages, and ratios reported in the following examples are on a weight basis, and all reagents used in the examples are commercially available or synthesized according to conventional methods and can be used directly without further treatment, and the equipment used in the examples is commercially available.
Examples 1 to 4
The anti-inflammatory and anti-aging essence disclosed by the embodiment of the application comprises the following components in percentage by mass:
lactobacillus fermentation lysate, 1% -5%;
(ii) a secondary split yeast fermentation product lysate, 5% -15%;
1% -3% of at least one of hyaluronic acid, hyaluronate and hyaluronic acid derivative;
0.05 to 0.3 percent of tocopherol acetate;
0.1% -0.3% of bisabolol;
0.5 to 8 percent of humectant;
0.5 to 8 percent of preservative;
0.1 to 8 percent of thickening agent;
0.1 to 3 percent of pH regulator
0.1% -5% of metal chelating agent;
0.1 to 1 percent of vegetable oil;
0-1.5% of caffeine;
0.2 to 8 percent of emulsifier;
93.3 to 99.85 percent of water.
The contents of the components of the examples are shown in Table 1.
The preparation method of the anti-inflammatory and anti-aging essence comprises the following steps:
preparing an aqueous phase solution: mixing a humectant, a preservative, a thickener, and a metal chelator;
mixing at least one of aqueous phase solution, lactobacillus fermentation lysate, schizosaccharomyces fermentation lysate, hyaluronic acid, hyaluronate, hyaluronic acid derivative, tocopherol acetate, vegetable oil and fat, and emulsifier, homogenizing and emulsifying, and adding pH regulator to obtain the anti-inflammatory and anti-aging essence.
Preparing a hyaluronic acid mixed solution: mixing sodium hyaluronate, a sodium hyaluronate cross-linked polymer (weight average molecular weight of 1000000), hydrolyzed hyaluronic acid and sodium acetylated hyaluronate according to a weight ratio of 1. The sodium hyaluronate has a number average molecular weight of 5000-10000, and also has a number average molecular weight of 800000-100000, and a mass ratio of 1:1; the hyaluronic acid comprises a number average molecular weight of 5000-10000, and further comprises a hyaluronic acid with a number average molecular weight of 800000-100000, in a mass ratio of 1:1; the weight average molecular weight of the acetylated hyaluronic acid is 1000000; all raw materials are from Furuida.
The lactobacillus fermentation lysate was from korean SK Bioland, the schizosaccharomyces fermentation lysate was from korean SK Bioland, the bisabolol was from BASF, and the tocopherol acetate was from BASF.
The other materials may be from any commercially available cosmetic raw materials company.
TABLE 1
Comparative example 1
The comparative example of the present application differs from example 1 in that: the anti-inflammatory and anti-aging essence lotion has different components and contents.
TABLE 2
Test section
1) And (3) safety testing:
the experimental steps are as follows: 30 volunteers, 6 of each volunteer, were divided into two groups, and the anti-inflammatory and anti-aging essence lotion samples of examples 1-5 were tested, each tester performed a spot-patch control experiment on the inner sides of the left and right arms, and the inner side of the left hand was coated with 1.0g of the product of the present invention each time, and the inner side of the right hand was coated with 1.0g of blank base material twice a day, and the skin reaction phenomena after 24h, 48h, and 72h were recorded.
The experimental results are as follows: after the anti-inflammatory and anti-aging essence lotion samples of examples 1 to 4 were coated for 24 hours, 48 hours and 72 hours, no allergic phenomena such as skin redness or erythema appeared, which indicates that the anti-inflammatory and anti-aging essence lotions of the anti-inflammatory and anti-aging essence lotion samples of examples 1 to 4 are safe and have no adverse reaction phenomenon.
2) Stability test
The anti-wrinkle compositions of examples 1-5 were subjected to stability tests, including heat, cold, alternating and light tests. Wherein, the heat resistance test conditions are as follows: keeping the temperature at 45 +/-1 ℃ and keeping out of the sun; the cold resistance test conditions are as follows: keeping the temperature at minus 20 +/-1 ℃ and keeping out of the sun; the alternating test conditions were: keeping the temperature at minus 20 ℃ for 3.5 days, changing the temperature at 45 ℃ for 3.5 days, and keeping out of the sun; the illumination test conditions were: the test chamber (1.47X 106 Lux. Hr) was illuminated, and the test results are shown in Table 3.
Table 3 examples and comparative examples the results of stability testing of the wrinkle resistant compositions.
| Sample (I) | Heat resistance | Cold-resistant | Alternation | Illumination of light |
| Example 1 | No abnormality | No abnormality | No abnormality | No abnormality |
| Example 2 | No abnormality | No abnormality | No abnormality | No abnormality |
| Example 3 | No abnormality | No abnormality | No abnormality | No abnormality |
| Example 4 | No abnormality | No abnormality | No abnormality | No abnormality |
As can be seen from table 3, the anti-inflammatory and anti-aging essence disclosed in the embodiments of the present application has excellent stability, compatibility and stability.
3) Anti-wrinkle test
1. Dividing volunteers into 8 groups at random, wherein each group has 30 individuals, the age is 35-45 years, and the position and area of each group of test area are the same;
2. each group of volunteers continuously used the samples of examples 1-4 and the samples of practical examples 1-5 for 4 weeks, respectively, the using time and the using amount of each group are consistent, and other functional cosmetics are not used during the testing period;
3. volunteers self-evaluate the aging improvement and skin firmness. The wrinkles are reduced to 5 points full with naked eyes and are not changed to 0 point; the skin firmness is improved better, and the skin can be seen to be firmer to a full score of 5 points without changing to 0 point. As shown in table 4.
Table 4 examples and comparative examples anti-inflammatory anti-aging essence lotion aging improvement and skin firmness.
| Sample (I) | Aging improvement score | Skin firmness score |
| Example 1 | 4.0 | 4.1 |
| Example 2 | 4.1 | 4.2 |
| Example 3 | 4.5 | 4.6 |
| Example 4 | 4.9 | 4.9 |
| Comparative example 1 | 3.8 | 3.7 |
| Comparative example 2 | 3.5 | 3.4 |
| Comparative example 3 | 3.6 | 3.4 |
| Comparative example 4 | 3.3 | 3.1 |
| Comparative example 5 | 3.9 | 3.7 |
In addition, the skin of the forehead and the wrinkle part of the face of the volunteer is coated by using the examples and comparative examples of the application, and the anti-aging effect is detected by adopting an Antera 3D skin tester to test the roughness and the wrinkle roughness. In agreement with the scores of the above-mentioned table.
The skin using examples and comparative examples was subjected to a non-invasive imaging operation using an optical coherence tomography skin scanner to obtain pictures 1-2.
The non-invasive imaging of collagen of example 1, as shown in fig. 1, is the initial state of the skin; fig. 2 shows the state of the anti-inflammatory and anti-aging essence of the present application after 28 days. As can be seen from the figure, example 1 has the effect of promoting collagen production, and can achieve anti-aging.
4) Effect on photoaging 3D full-thickness skin model
The effects of the anti-inflammatory and anti-aging essence lotions of the examples and comparative examples on the photoaging 3D full-thickness skin model were tested.
An experimental instrument: an ultra-clean bench, a carbon dioxide incubator, UVA and UVB irradiators, a microplate reader (BIO-TEK), and a cryomicrotome (Leica).
Experiment reagents and consumables: 3D full-thickness skin model (self-made in laboratory), ELISA detection kit with different indexes, MTT kit and the like.
The experimental procedure was as follows:
(1) 3D full-layer model construction: constructing a 3D skin model by using keratinocytes and fibroblasts;
(2) Molding and dosing: SSUV irradiation treatment (UVA: 30J/cm2; UVB:50 mJ/cm) was performed every day when the model was shipped, i.e., 0 day 2 ) Then respectively coating a certain amount of samples on the surfaces of corresponding models, coating model culture solution only by contrast of the models, coating 6 composite holes in each composition once a day, and coating the composite holes once a day for a total action time of 4 days;
(3) Collecting and detecting: after the action of the sample is finished, collecting culture solution, taking 3 models of Shanghai enzyme-linked biology company in each group, carrying out the determination of model activity by using an MTT kit, carrying out tissue fixation on the remaining 3 models, and carrying out IHC (IHC staining) to determine the content of collagen at the true epidermal junction;
(4) And (3) analysis: and (5) performing statistical analysis by using a Test method.
The test results are shown in the following table.
TABLE 5
The above results indicate that the samples of the examples improve the tissue viability of the 3D full-thickness skin model, promote the expression of collagen at the junction of the true epidermis, and improve the tissue viability, indicating that at least one of the lactobacillus fermentation lysate, the yeast fermentation lysate, the hyaluronic acid, the hyaluronate, the hyaluronic acid derivative, the tocopherol acetate, and the bisabolol produce an obvious synergistic effect.
5) Influence on human skin morphology
In this example, the volunteers were tested for wrinkle change in the right and left canthus, cheek moisture and TEWL change after 2 weeks and 4 weeks using the sunny slope of examples and comparative examples to evaluate the anti-inflammatory and anti-aging essence for its efficacy of anti-wrinkle, increasing skin moisture content and improving skin barrier function, with subjects on the wrinkle grade of 1-5 as the subjects.
The following tests were performed on volunteers before, 2 weeks and 4 weeks after using the product, respectively, using the half-face control test method:
1) Taking pictures of external canthus on left and right sides of a volunteer by using primos, and calculating parameters including wrinkle number, wrinkle area, wrinkle depth and the like by using software;
2) Testing the moisture content of the skin of the cheeks on the left and right sides by using a Corneometer;
3) The left and right cheeks were tested for their rate of percutaneous water loss (TEWL values) using a Tewameter.
After face cleaning in the morning and evening, a proper amount of test sample is taken after the lotion is used and is respectively and uniformly applied to the left face and the right face (including the periphery of eyes), the original skin care habit is kept unchanged in the whole test process, and the test sample is only used for replacing the face cream used by each subject.
The adopted test instrument is as follows:
primos (Canfield, USA)
Skin moisture tester Corneometer (Courage & Khazaka, germany)
Skin moisture loss tester Tewameter (Courage & Khazaka, germany)
The test procedure was as follows:
1) The tested areas were lateral external canthus, forehead and cheek. Before the test, the testee uniformly cleans the face with facial cleanser, and then wipes the face clean with a non-scrap absorbent paper towel;
2) Sitting still for 20 minutes in a room meeting the standard, water and beverages can not be drunk, the tested area is exposed and kept relaxed, and the tested area is prevented from being touched;
3) The left and right canthus are randomly divided into a product smearing area and a blank control area to ensure that the balance is achieved statistically;
4) During testing, the same facial fixing facility and fixing mode are adopted, and according to primos use instructions, pictures of wrinkles of left and right external canthus of a subject before use, after 2 weeks and 4 weeks of use are collected, and a Corneometer and a Tewameter are used for testing the moisture value of the cheek and the TEWL value of the volunteer on two sides respectively.
Number of subjects: the group was 30, with a mean age of 45.5 ± 8.5 years. The test results were averaged as follows.
(1) Number of wrinkles, wrinkle depth and wrinkle area (per 2 cm) 2 Area)
Table 6: number of wrinkles, wrinkle depth and wrinkle area test results (mean ± SD value, n = 30)
| Sample (I) | Number of wrinkles | Depth of wrinkles | Wrinkle area index |
| Blank control group | 62.81±0.73 | 75um | 2.33 |
| Example 1 | 55.40±0.50 | 55um | 1.81 |
| Example 2 | 53.35±0.38 | 53um | 1.78 |
| Example 3 | 51.34±0.65 | 48um | 1.66 |
| Example 4 | 48.50±0.54 | 45um | 1.50 |
| Comparative example 1 | 59.32±0.41 | 65um | 1.92 |
| Comparative example 2 | 60.01±0.60 | 68um | 2.23 |
| Comparative example 3 | 58.34±0.44 | 70um | 2.03 |
| Comparative example 4 | 57.90±0.35 | 64um | 1.98 |
| Comparative example 5 | 56.39±0.49 | 68um | 1.93 |
Note: "x" indicates p <0.01 compared to before use of the product.
The number of wrinkles is used to characterize the number of canthus wrinkles, with higher numbers indicating more wrinkles and fewer wrinkles. The number of skin wrinkles gradually decreased after the use of the example group, and the decrease in the number of wrinkles was very significant by 4 weeks (p < 0.01). The comparative example group had no significant difference in wrinkle area after 4 weeks of use compared to before use (P > 0.05).
Wrinkle depth is used to characterize the depth of the canthus wrinkles, with higher values indicating deeper wrinkles and conversely lighter wrinkles. The skin wrinkle depth gradually decreased after the use of the samples of the example group, and the wrinkle depth decrease was very significant up to 4 weeks (p < 0.01). The control group had no significant difference in wrinkle depth after 4 weeks of use compared to before use (P > 0.05).
The wrinkle area index is used to characterize the total area of canthus wrinkles, with higher values indicating more wrinkles and fewer wrinkles. The wrinkle area of the skin gradually decreased after the use of the example group, and the wrinkle area decreased very significantly by 4 weeks (p < 0.01). The wrinkle area of the sample of the comparative example group was not significantly different after 4 weeks of use compared to before use (P > 0.05). Compared with the comparative example group, the difference of the example group after 4 weeks of use is significant (p < 0.01), which indicates that the anti-inflammatory and anti-aging essence of the example has significant efficacy of reducing skin wrinkles.
(2) Moisture content and TEWL value
Table 7: moisture content and TEWL value test results (mean. + -. SD value, n = 30)
| Sample (I) | Rate of change of moisture content | TEWL |
| Blank control group | - | 12.5％ |
| Example 1 | 21％ | 10.5％ |
| Example 2 | 20％ | 10.8％ |
| Example 3 | 25％ | 9.1％ |
| Example 4 | 28％ | 8.9％ |
| Comparative example 1 | 15％ | 12.1％ |
| Comparative example 2 | 18％ | 11.4％ |
| Comparative example 3 | 13％ | 11.5％ |
| Comparative example 4 | 17％ | 12.0％ |
| Comparative example 5 | 15％ | 11.9％ |
Note: "x" indicates p <0.01 compared to before use of the product.
And the water content variation rate is used for representing the water content of the stratum corneum of the skin, the water content of the blank control group is subtracted from the measured water content, and the obtained difference is divided by the water content of the blank control group to obtain the water content variation rate. If the moisture is reduced, it is negative, and the moisture is increased, it is positive. The higher the value the higher the skin moisture content, whereas the lower the skin moisture content. The samples of the example group showed a gradual increase in skin moisture content after application, with a very significant increase by 4 weeks (p < 0.01). The comparative example group samples showed no significant difference in skin moisture content after 4 weeks of use compared to the pre-use (P > 0.05). After 4 weeks of use, the samples of the example group were very significantly different (p < 0.01) from the samples of the comparative example group, indicating that the example group had the efficacy of increasing the moisture content of the skin.
TEWL is used to characterize the barrier function of the skin cutin, the higher the number the poorer the barrier function of the skin and vice versa. The TEWL values gradually decreased after use for the samples of the example group, with a significant decrease by 4 weeks (p < 0.05). The TEWL value after 4 weeks of use of the control group was not significantly different from that before use (P > 0.05). After 4 weeks of use, the difference between the example group and the comparative example group was significant (p < 0.05), indicating that the example group had efficacy in repairing skin barrier function.
While the invention has been described with reference to specific embodiments, the scope of the invention is not limited thereto, and those skilled in the art can easily conceive various equivalent modifications or substitutions within the technical scope of the invention. Therefore, the protection scope of the present application shall be subject to the protection scope of the claims.
Claims (10)
1. An anti-inflammatory and anti-aging composition comprises the following components in parts by weight:
lactobacillus fermentation lysate, 10 parts;
10-150 parts of a schizosaccharomyces cerevisiae fermentation product lysate;
2-30 parts of at least one of hyaluronic acid, hyaluronate and hyaluronic acid derivatives;
0.1-3 parts of tocopherol acetate;
0.2-3 parts of bisabolol.
2. The anti-inflammatory and anti-aging composition according to claim 1, which comprises the following components in parts by weight:
lactobacillus fermentation lysate, 10 parts;
20-100 parts of a schizosaccharomyces cerevisiae fermentation product lysate;
5-20 parts of at least one of hyaluronic acid, hyaluronate and hyaluronic acid derivatives;
1-2 parts of tocopherol acetate;
1-2 parts of bisabolol.
3. The anti-inflammatory and anti-aging composition according to claim 1 or 2, which comprises the following components in parts by weight:
lactobacillus fermentation lysate, 10 parts;
split yeast fermentation lysate, 20-50;
5-10 parts of at least one of hyaluronic acid, hyaluronate and hyaluronic acid derivatives;
1-1.5 parts of tocopherol acetate;
1-1.5 parts of bisabolol.
4. The anti-inflammatory and anti-aging essence comprises the following components in percentage by mass:
lactobacillus fermentation lysate, 1% -5%;
(ii) a secondary split yeast fermentation product lysate, 5% -15%;
1% -3% of at least one of hyaluronic acid, hyaluronate and hyaluronic acid derivative;
0.05 to 0.3 percent of tocopherol acetate;
0.1% -0.3% of bisabolol;
0-8% of humectant;
0-8% of preservative;
0.1 to 8 percent of thickening agent;
0 to 3 percent of pH regulator
0-5% of metal chelating agent;
0.1 to 1 percent of vegetable oil;
0.2 to 8 percent of emulsifier;
92.4 to 99.85 percent of water.
5. The anti-inflammatory and anti-aging essence lotion as claimed in claim 4, which comprises the following components in percentage by mass:
lactobacillus fermentation lysate, 1% -5%;
(ii) a secondary split yeast fermentation lysate, 5% -15%;
1% -3% of at least one of hyaluronic acid, hyaluronate and hyaluronic acid derivative;
0.1% -0.3% of tocopherol acetate;
0.1% -0.3% of bisabolol;
0.5 to 8 percent of humectant;
0.5 to 8 percent of preservative;
0.1 to 8 percent of thickening agent;
0.1-3% of pH regulator;
0.1% -5% of metal chelating agent;
0.1 to 1 percent of vegetable oil and fat;
0.2 to 8 percent of emulsifier;
93.3 to 99.85 percent of water.
6. The anti-inflammatory and anti-aging essence according to claim 4 or 5, wherein the humectant is selected from glycerin, butylene glycol, 1, 3-propylene glycol, 1, 2-pentanediol, caprylyl glycol or a combination thereof; and/or the presence of a gas in the gas,
the preservative is selected from phenoxyethanol, p-hydroxyacetophenone, 1, 2-pentanediol, 1, 2-hexanediol, caprylyl glycol, ethylhexyl glycerin, benzoic acid, sodium benzoate, caprylyl hydroxamic acid, or combinations thereof; and/or the presence of a gas in the atmosphere,
the thickening agent is selected from carbomer, acrylic acid cross-linked polymer with C10-C30 alkanol acrylate, xanthan gum or combination thereof; and/or the presence of a gas in the gas,
the pH regulator is selected from arginine, tromethamine, sodium hydroxide water emulsion or the combination thereof; the water-soluble polymer can be selected as a sodium hydroxide water emulsion with the mass fraction of 5%; and/or the presence of a gas in the gas,
the metal chelating agent is selected from disodium ethylenediaminetetraacetate, EDTA, hydroxyethane diphosphonic acid or a combination thereof.
7. The anti-inflammatory and anti-aging essence according to claim 4 or 5, wherein the vegetable oil and fat is selected from jojoba oil, sunflower seed oil, castor oil, coconut oil, grape seed oil, shea butter, meadowfoam seed oil, macadamia nut oil, olive oil, palm oil, squalane, cocoa butter, jojoba fat, glycolipids, octyldodecanol, caprylic/capric triglyceride, coco-caprylic/capric triglyceride, oleic acid, linoleic acid, linolenic acid polyglycerol esters and dioctyl dodecanol dimer linoleate or a combination thereof; and/or the presence of a gas in the gas,
the emulsifier is selected from oleyl polyether-3 phosphate, oleyl polyether-3, oleyl polyether-5 or a combination thereof; and/or the presence of a gas in the gas,
the water is selected from deionized water, yeast bifidus fermentation filtrate or combination thereof.
8. A method for preparing the anti-inflammatory and anti-aging essence lotion as claimed in any one of claims 4 to 7, comprising:
preparing an aqueous phase solution: mixing a humectant, a preservative, a thickener, and a metal chelator;
mixing at least one of aqueous phase solution, lactobacillus fermentation lysate, schizosaccharomyces fermentation lysate, hyaluronic acid, hyaluronate, hyaluronic acid derivative, tocopherol acetate, vegetable fat and oil, and emulsifier, homogenizing and emulsifying to obtain the anti-inflammatory and anti-aging essence.
9. The method of claim 8, wherein preparing the aqueous solution comprises: the humectant, the preservative, the thickener, and the metal chelator are mixed under heating to mix the solutions uniformly.
10. An anti-inflammatory anti-aging cosmetic or pharmaceutical composition comprising: an anti-inflammatory and anti-ageing composition as claimed in any one of claims 1 to 3, together with a cosmetically acceptable adjuvant.
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