CN115867318A - 一种脂质纳米颗粒 - Google Patents

一种脂质纳米颗粒 Download PDF

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CN115867318A
CN115867318A CN202180050252.3A CN202180050252A CN115867318A CN 115867318 A CN115867318 A CN 115867318A CN 202180050252 A CN202180050252 A CN 202180050252A CN 115867318 A CN115867318 A CN 115867318A
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lipid
rna
cancer
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李林鲜
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Shenzhen Xinxin Biotechnology Co ltd
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Shenzhen Xinxin Biotechnology Co ltd
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    • C07C229/16—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton the nitrogen atom of the amino group being further bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings to carbon atoms of hydrocarbon radicals substituted by amino or carboxyl groups, e.g. ethylenediamine-tetra-acetic acid, iminodiacetic acids
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    • C07C233/36—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom having the carbon atom of the carboxamide group bound to a hydrogen atom or to a carbon atom of an acyclic saturated carbon skeleton
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Abstract

本发明涉及一种脂质纳米颗粒。所述脂质纳米颗粒由以下结构(I)的化合物或其药物可接受的盐、互变异构体或立体异构体形成。本发明还提供了所述脂质纳米颗粒用于递送治疗剂组分的用途。本发明还涉及所述脂质纳米颗粒在制备药物中的用途。

Description

PCT国内申请，说明书已公开。

Claims (16)

  1. PCT国内申请，权利要求书已公开。
CN202180050252.3A 2020-08-20 2021-08-12 一种脂质纳米颗粒 Pending CN115867318A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CN202010841678.8A CN114073677B (zh) 2020-08-20 2020-08-20 一种脂质纳米颗粒
CN2020108416788 2020-08-20
PCT/CN2021/112167 WO2022037465A1 (zh) 2020-08-20 2021-08-12 一种脂质纳米颗粒

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CN115867318A true CN115867318A (zh) 2023-03-28

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CN202180050252.3A Pending CN115867318A (zh) 2020-08-20 2021-08-12 一种脂质纳米颗粒

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US (1) US20230310334A1 (zh)
EP (1) EP4201400A1 (zh)
JP (1) JP2023538640A (zh)
KR (1) KR20230051553A (zh)
CN (2) CN114073677B (zh)
AU (1) AU2021329702B2 (zh)
CA (1) CA3190084A1 (zh)
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AU2023225913A1 (en) * 2022-02-28 2024-10-10 Shenzhen Shenxin Biotechnology Co., Ltd. Amino lipid compound, preparation method therefor, composition thereof and use thereof
CN116813493A (zh) * 2022-03-21 2023-09-29 苏州科锐迈德生物医药科技有限公司 一种脂质化合物及基于其的脂质载体、核酸脂质纳米粒组合物和药物制剂
CN116969851A (zh) * 2022-04-29 2023-10-31 北京剂泰医药科技有限公司 可电离脂质化合物
CN117417264A (zh) * 2022-07-19 2024-01-19 深圳深信生物科技有限公司 氨基脂质化合物、其制备方法和应用
WO2024149331A1 (zh) * 2023-01-11 2024-07-18 深圳深信生物科技有限公司 一种氨基脂质化合物、其制备方法和应用
CN118666726A (zh) * 2023-03-17 2024-09-20 尧唐(上海)生物科技有限公司 递送治疗剂的脂质化合物及其制备方法与应用

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SI3766916T1 (sl) * 2014-06-25 2023-01-31 Acuitas Therapeutics Inc. Formulacije novih lipidov in lipidnih nanodelcev za dostavo nukleinskih kislin
EP3289083A4 (en) * 2015-04-27 2018-12-19 The Trustees Of The University Of Pennsylvania Nucleoside-modified rna for inducing an adaptive immune response
CA3003055C (en) * 2015-10-28 2023-08-01 Acuitas Therapeutics, Inc. Lipids and lipid nanoparticle formulations for delivery of nucleic acids
US20190167811A1 (en) * 2016-04-13 2019-06-06 Modernatx, Inc. Lipid compositions and their uses for intratumoral polynucleotide delivery
KR102482867B1 (ko) * 2016-05-18 2023-01-02 모더나티엑스, 인크. 면역 조정 폴리펩타이드를 암호화하는 mRNA의 조합물 및 이의 용도
IL266194B2 (en) * 2016-10-26 2023-09-01 Curevac Ag mRNA vaccines with lipid nanoparticles
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WO2019226650A1 (en) * 2018-05-23 2019-11-28 Modernatx, Inc. Delivery of dna
WO2020061367A1 (en) * 2018-09-19 2020-03-26 Modernatx, Inc. Compounds and compositions for intracellular delivery of therapeutic agents

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US20230310334A1 (en) 2023-10-05
KR20230051553A (ko) 2023-04-18
EP4201400A1 (en) 2023-06-28
AU2021329702B2 (en) 2024-03-21
CN114073677A (zh) 2022-02-22
CA3190084A1 (en) 2022-02-24
WO2022037465A1 (zh) 2022-02-24
AU2021329702A1 (en) 2023-05-04
CN114073677B (zh) 2023-06-09
JP2023538640A (ja) 2023-09-08

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