CN115844967A - Compound iodine disinfectant and preparation method and application thereof - Google Patents
Compound iodine disinfectant and preparation method and application thereof Download PDFInfo
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- CN115844967A CN115844967A CN202211085568.9A CN202211085568A CN115844967A CN 115844967 A CN115844967 A CN 115844967A CN 202211085568 A CN202211085568 A CN 202211085568A CN 115844967 A CN115844967 A CN 115844967A
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- ZCYVEMRRCGMTRW-UHFFFAOYSA-N 7553-56-2 Chemical compound [I] ZCYVEMRRCGMTRW-UHFFFAOYSA-N 0.000 title claims abstract description 85
- 229910052740 iodine Inorganic materials 0.000 title claims abstract description 85
- 239000011630 iodine Substances 0.000 title claims abstract description 85
- 239000000645 desinfectant Substances 0.000 title claims abstract description 52
- 150000001875 compounds Chemical class 0.000 title claims abstract description 37
- 238000002360 preparation method Methods 0.000 title claims abstract description 10
- 229960002152 chlorhexidine acetate Drugs 0.000 claims abstract description 34
- 239000003814 drug Substances 0.000 claims abstract description 34
- MCSINKKTEDDPNK-UHFFFAOYSA-N propyl propionate Chemical compound CCCOC(=O)CC MCSINKKTEDDPNK-UHFFFAOYSA-N 0.000 claims abstract description 34
- 241000316658 Sauromatum giganteum Species 0.000 claims abstract description 26
- UAJTZZNRJCKXJN-UHFFFAOYSA-M sodium;2-dodecoxy-2-oxoethanesulfonate Chemical compound [Na+].CCCCCCCCCCCCOC(=O)CS([O-])(=O)=O UAJTZZNRJCKXJN-UHFFFAOYSA-M 0.000 claims abstract description 23
- 241000576429 Forsythia suspensa Species 0.000 claims abstract description 20
- 241000915604 Scutellaria barbata Species 0.000 claims abstract description 19
- 239000000126 substance Substances 0.000 claims abstract description 18
- 239000002994 raw material Substances 0.000 claims abstract description 6
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 30
- 238000000605 extraction Methods 0.000 claims description 29
- 238000002156 mixing Methods 0.000 claims description 18
- 239000000284 extract Substances 0.000 claims description 17
- 239000002775 capsule Substances 0.000 claims description 7
- 238000000034 method Methods 0.000 claims description 6
- 238000001816 cooling Methods 0.000 claims description 4
- 241000207929 Scutellaria Species 0.000 claims description 3
- 230000036541 health Effects 0.000 claims description 3
- 241000555712 Forsythia Species 0.000 claims description 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 230000002147 killing effect Effects 0.000 abstract description 13
- 241000222122 Candida albicans Species 0.000 abstract description 10
- 241000588724 Escherichia coli Species 0.000 abstract description 10
- 241000191967 Staphylococcus aureus Species 0.000 abstract description 10
- 229940095731 candida albicans Drugs 0.000 abstract description 10
- 238000004659 sterilization and disinfection Methods 0.000 abstract description 9
- 241000700605 Viruses Species 0.000 abstract description 7
- 231100000252 nontoxic Toxicity 0.000 abstract description 5
- 230000003000 nontoxic effect Effects 0.000 abstract description 5
- 241000204031 Mycoplasma Species 0.000 abstract description 3
- 210000002421 cell wall Anatomy 0.000 abstract description 3
- 230000009385 viral infection Effects 0.000 abstract description 3
- 241000007181 unidentified human coronavirus Species 0.000 abstract 1
- 239000000243 solution Substances 0.000 description 31
- 244000309467 Human Coronavirus Species 0.000 description 6
- 238000003756 stirring Methods 0.000 description 6
- 239000002131 composite material Substances 0.000 description 5
- 230000000694 effects Effects 0.000 description 5
- CPKVUHPKYQGHMW-UHFFFAOYSA-N 1-ethenylpyrrolidin-2-one;molecular iodine Chemical compound II.C=CN1CCCC1=O CPKVUHPKYQGHMW-UHFFFAOYSA-N 0.000 description 3
- 229920000742 Cotton Polymers 0.000 description 3
- 241001183967 Isodon Species 0.000 description 3
- 229920000153 Povidone-iodine Polymers 0.000 description 3
- 230000002779 inactivation Effects 0.000 description 3
- 239000000463 material Substances 0.000 description 3
- 239000000203 mixture Substances 0.000 description 3
- 229960001621 povidone-iodine Drugs 0.000 description 3
- 239000000843 powder Substances 0.000 description 3
- 230000001954 sterilising effect Effects 0.000 description 3
- 241000894006 Bacteria Species 0.000 description 2
- 210000004027 cell Anatomy 0.000 description 2
- 238000006243 chemical reaction Methods 0.000 description 2
- 230000018044 dehydration Effects 0.000 description 2
- 238000006297 dehydration reaction Methods 0.000 description 2
- 238000001914 filtration Methods 0.000 description 2
- 230000036039 immunity Effects 0.000 description 2
- 208000015181 infectious disease Diseases 0.000 description 2
- PNDPGZBMCMUPRI-UHFFFAOYSA-N iodine Chemical compound II PNDPGZBMCMUPRI-UHFFFAOYSA-N 0.000 description 2
- 239000002244 precipitate Substances 0.000 description 2
- 231100000331 toxic Toxicity 0.000 description 2
- 230000002588 toxic effect Effects 0.000 description 2
- 231100000419 toxicity Toxicity 0.000 description 2
- 230000001988 toxicity Effects 0.000 description 2
- 235000009161 Espostoa lanata Nutrition 0.000 description 1
- 240000001624 Espostoa lanata Species 0.000 description 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 1
- 241000233866 Fungi Species 0.000 description 1
- 206010061218 Inflammation Diseases 0.000 description 1
- 206010052428 Wound Diseases 0.000 description 1
- 208000027418 Wounds and injury Diseases 0.000 description 1
- 238000005299 abrasion Methods 0.000 description 1
- 230000000844 anti-bacterial effect Effects 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000003749 cleanliness Effects 0.000 description 1
- 238000004040 coloring Methods 0.000 description 1
- 239000013078 crystal Substances 0.000 description 1
- 230000006378 damage Effects 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- 230000004054 inflammatory process Effects 0.000 description 1
- 230000007794 irritation Effects 0.000 description 1
- 210000004072 lung Anatomy 0.000 description 1
- 239000011259 mixed solution Substances 0.000 description 1
- 239000000178 monomer Substances 0.000 description 1
- 244000052769 pathogen Species 0.000 description 1
- 239000012466 permeate Substances 0.000 description 1
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- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- 239000003440 toxic substance Substances 0.000 description 1
- 231100000820 toxicity test Toxicity 0.000 description 1
- 231100000041 toxicology testing Toxicity 0.000 description 1
- 241001515965 unidentified phage Species 0.000 description 1
- 230000037303 wrinkles Effects 0.000 description 1
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Abstract
The invention belongs to the technical field of medical disinfection solution, and particularly relates to a compound iodine disinfection solution as well as a preparation method and application thereof. The invention provides a compound iodine disinfectant, which comprises the raw materials of traditional Chinese medicine components and chemical components; the traditional Chinese medicine components comprise barbed skullcap herb, herba houttuyniae, weeping forsythia and typhonium giganteum; the chemical components include iodine and chlorhexidine acetate. The compound iodine disinfectant has the killing rate of 99.99 percent on staphylococcus aureus, escherichia coli and candida albicans in the environment, can break the cell wall of human coronavirus HC0V-229E mycoplasma, enhances the resistance to virus infection, has the killing rate of 94.98 percent on HC0V-229E virus, is actually nontoxic, and can be safely used.
Description
Technical Field
The invention belongs to the technical field of medical disinfectant, and particularly relates to a compound iodine disinfectant as well as a preparation method and application thereof.
Background
In daily life, entertainment and work of people, the damage and abrasion of skin caused by various accidents are inevitable. The disinfection of human skin often uses a cotton ball or cotton swab, and the disinfection process is generally divided into two steps: firstly, using absorbent cotton containing iodine tincture to wipe the skin to achieve the aim of killing bacteria; secondly, to eliminate the irritation of the disinfectant to the skin, a second wipe was performed using alcohol-containing cotton wool, which diluted the iodine tincture content on the skin.
The iodine disinfectant is a high-efficiency broad-spectrum disinfectant which takes iodine as a main sterilization component and has the function of sterilizing protein precipitates through free iodine elements, and can quickly kill pathogens such as bacteria, spores, viruses, bacteriophage, fungi and the like. However, the existing composite iodophor disinfectant has poor disinfection effect and is not beneficial to the rapid disinfection of wounds.
Disclosure of Invention
The invention aims to make up for the defects of the prior art, and provides a compound iodine disinfectant, a preparation method and application thereof, so as to improve the disinfection effect.
The invention provides a compound iodine disinfectant, wherein the raw materials of the compound iodine disinfectant comprise traditional Chinese medicine components and chemical components;
the traditional Chinese medicine components comprise barbed skullcap herb, herba houttuyniae, weeping forsythia and typhonium giganteum;
the chemical components include iodine and chlorhexidine acetate.
Preferably, the mass ratio of the traditional Chinese medicine components to the chemical components is 30 (2.42-2.50).
Preferably, the mass ratio of the sculellaria barbata to the herba houttuyniae to the fructus forsythiae to the typhonium giganteum is 3; the mass ratio of the iodine to the chlorhexidine acetate is (1.14-1.18): (1.28-1.32).
The invention also provides a preparation method of the compound iodine disinfectant, which comprises the following steps:
mixing and extracting the sculellaria barbata, the herba houttuyniae, the fructus forsythiae and the typhonium giganteum with water to obtain a traditional Chinese medicine extract;
mixing the iodine and water to obtain an iodine solution;
mixing the chlorhexidine acetate with water to obtain a chlorhexidine acetate solution;
and mixing the traditional Chinese medicine extract, an iodine solution and a chlorhexidine acetate solution to obtain the compound iodine disinfectant.
Preferably, the mixed extraction comprises a first extraction and a second extraction;
the temperature of the first extraction is 120 ℃, and the time of the first extraction is 30min;
the temperature of the second extraction is 60-65 ℃, and the time of the second extraction is 20min.
Preferably, in the first extraction, the mass sum of the barbat skullcap, herba houttuyniae, forsythia suspense and typhonium giganteum and the mass ratio of water are 3.
Preferably, after the mixing and extracting, the method further comprises: cooling the obtained extractive solution to 60 deg.C to obtain the Chinese medicinal extract.
Preferably, when the iodine solution is prepared, the mass ratio of iodine to water is 1.16.
Preferably, the mass ratio of the chlorhexidine acetate to the water is 1.3.
The invention also provides the application of the compound iodine disinfectant in medical treatment and health care.
The invention provides a compound iodine disinfectant, which comprises the raw materials of traditional Chinese medicine components and chemical components; the traditional Chinese medicine components comprise barbed skullcap herb, herba houttuyniae, weeping forsythia and typhonium giganteum; the chemical components include iodine and chlorhexidine acetate. The invention takes the barbed skullcap herb, the herba houttuyniae, the weeping forsythia and the typhonium giganteum as the traditional Chinese medicine components, has the functions of clearing away the lung-heat, improving the immunity and clearing away heat and toxic materials, takes the iodine and the chlorhexidine acetate as the chemical components, and can sterilize in a broad spectrum. The composite iodine disinfectant obtained by combining the traditional Chinese medicine components and the chemical components has the killing rate of 99.99 percent on staphylococcus aureus, escherichia coli and candida albicans in the environment, can break the cell wall of human coronavirus HC0V-229E mycoplasma, enhances the resistance to virus infection, has the inactivation rate of 94.98 percent on HC0V-229E virus, is actually nontoxic and can be safely used.
Drawings
In order to more clearly illustrate the embodiments of the present invention or the technical solutions in the prior art, the drawings required in the embodiments will be briefly described below.
FIGS. 1-2 show the killing effect of the compound iodine disinfectant on Escherichia coli, staphylococcus aureus and Candida albicans;
FIG. 3 shows the result of identifying the neutralizer;
FIG. 4 shows the results of toxicity tests.
Detailed Description
The invention provides a compound iodine disinfectant, which comprises the following raw materials of traditional Chinese medicine components and chemical components; the traditional Chinese medicine components comprise barbed skullcap herb, herba houttuyniae, weeping forsythia and typhonium giganteum; the chemical components include iodine and chlorhexidine acetate.
In the invention, the traditional Chinese medicine components comprise barbed skullcap herb, herba houttuyniae, weeping forsythia and typhonium giganteum; the herba Scutellariae Barbatae has effects of relieving inflammation and eliminating dampness; the product has the function of breaking the ear root and dredging, and accelerates the reaction; the fructus forsythiae has the function of removing toxicity; the typhonium giganteum has the function of removing toxicity. The mass ratio of the barbed skullcap herb, the herba houttuyniae, the weeping forsythia capsule and the typhonium giganteum is preferably 3. The invention combines the barbed skullcap herb, the herba houttuyniae, the weeping forsythia and the typhonium giganteum, strictly controls the proportion of 4 traditional Chinese medicine components, and has the functions of clearing away the lung-heat, improving the immunity of the lung and the organism, and clearing away heat and toxic materials.
In the present invention, the chemical components preferably include iodine and chlorhexidine acetate; the iodine has broad-spectrum sterilization and can permeate wrinkles of the skin; the chlorhexidine acetate solves the coloring problem and has a volatilization function. The iodine is preferably povidone iodine powder. The mass ratio of iodine to chlorhexidine acetate is preferably (1.14-1.18): (1.28 to 1.32), more preferably 1.16. The present invention combines iodine and chlorhexidine acetate, and strictly controls the ratio of iodine and chlorhexidine acetate, and has broad-spectrum bactericidal action.
In the present invention, the mass ratio of the traditional Chinese medicine component to the chemical component is preferably 30 (2.42 to 2.50), and more preferably 30. The traditional Chinese medicine components and the chemical components are mixed in proportion, so that the killing rate of staphylococcus aureus, escherichia coli and candida albicans in the environment can be enhanced, and the resistance to infection of human coronavirus HC0V-229E can be enhanced. The results of the examples show that the compound iodine disinfectant has the killing rate of 99.99 percent on escherichia coli, staphylococcus aureus and candida albicans and the killing rate of 94.98 percent on HC0V-229E virus, is practically nontoxic and can be safely used.
The invention also provides a preparation method of the compound iodine disinfectant, which comprises the following steps:
mixing and extracting the barbed skullcap herb, the herba houttuyniae, the weeping forsythia capsule, the typhonium giganteum and water to obtain a traditional Chinese medicine extract;
respectively mixing the iodine with the chlorhexidine acetate and water to obtain an iodine solution and a chlorhexidine acetate solution;
and mixing the traditional Chinese medicine extract, an iodine solution and a chlorhexidine acetate solution to obtain the compound iodine disinfectant.
The invention mixes and extracts the barbed skullcap herb, the herba houttuyniae, the weeping forsythia capsule, the typhonium giganteum and water to obtain the traditional Chinese medicine extract. The invention limits the mass of the barbed skullcap herb, the common rabdosia root, the weeping forsythia and the typhonium giganteum and the mass ratio of the barbed skullcap herb, the common rabdosia root, the weeping forsythia and the typhonium giganteum to the water, and can better play the functions of the barbed skullcap herb, the common rabdosia root, the weeping forsythia and the typhonium giganteum. The mixed extraction comprises a first extraction and a second extraction; the temperature of the first extraction is preferably 120 ℃, and the time is preferably 30min; in the first extraction process, the mass ratio of the barbat skullcap, the herba houttuyniae, the weeping forsythia capsule and the typhonium giganteum to the water is preferably 3. Preferably, the first extracting solution is collected after the first extraction is finished, and the dregs of a decoction after the first extraction are subjected to second extraction to obtain a second extracting solution; the temperature of the second extraction is preferably 60-65 ℃, and the time is preferably 20min; in the second extraction process, the mass ratio of the medicine residues to the water is preferably 1. In the invention, the first extracting solution and the second extracting solution are preferably combined and cooled to 60 ℃ to obtain the traditional Chinese medicine extract. The invention has no strict requirement on the cooling mode and can be operated conventionally. In the invention, before the barbed skullcap herb, the herba houttuyniae, the weeping forsythia capsule and the typhonium giganteum are mixed with water, the mixture of the barbed skullcap herb, the herba houttuyniae, the weeping forsythia capsule and the typhonium giganteum is preferably dehydrated. The invention has no strict requirement on the dehydration mode, and the water content of the mixture of the barbed skullcap herb, the herba houttuyniae, the weeping forsythia and the typhonium giganteum is adjusted to 1 percent by using the dehydrator; the time for dehydration is preferably 3 to 5min. The mixed extraction of the invention has the advantages of high speed, uniform extraction and good extraction effect, and can ensure the cleanliness and concentration of the traditional Chinese medicine extract.
The iodine is mixed with water to obtain an iodine solution. The mass ratio of iodine to water according to the present invention is preferably 1.16; the temperature of the water is preferably 80 ℃.
The invention mixes the chlorhexidine acetate with water to obtain chlorhexidine acetate solution. The mass ratio of chlorhexidine acetate to water is preferably 1.3; the temperature of the water is preferably 100 ℃.
After the traditional Chinese medicine extract, the iodine solution and the chlorhexidine acetate solution are obtained, the traditional Chinese medicine extract, the iodine solution and the chlorhexidine acetate solution are mixed to obtain the compound iodine disinfectant. The mixing mode is preferably stirring, the stirring mode is not strictly required, and the conventional stirring mode is adopted until the mixed solution is crystal clear and has no precipitate. The traditional Chinese medicine extract, the iodine solution and the chlorhexidine acetate solution are mixed to generate a complex reaction, so that the killing rate of staphylococcus aureus, escherichia coli and candida albicans in the environment can be improved, and the resistance to infection of human coronavirus HC0V-229E is enhanced.
The invention also provides the application of the compound iodine disinfectant in the technical scheme in medical treatment and health. The composite iodine disinfectant prepared by using traditional Chinese medicine components and chemical components as raw materials is innovatively used for preparing a novel environment-friendly disinfectant, can not achieve the effect of any existing monomer iodine disinfectant, and remarkably improves the killing rate of escherichia coli, staphylococcus aureus and candida albicans compared with the existing iodine disinfectant.
For further illustration of the present invention, the following detailed description of the composite iodine disinfectant, its preparation method and application are provided in conjunction with the accompanying drawings and examples, which should not be construed as limiting the scope of the present invention.
Example 1
The preparation method of the compound iodine disinfectant comprises the following steps:
1. preparing materials: 3g of barbed skullcap herb, 6g of herba houttuyniae, 9g of weeping forsythia, 12g of typhonium giganteum, 1.16g of povidone iodine powder and 1.3g of chlorhexidine acetate;
2. mixing herba Scutellariae Barbatae, herba Houttuyniae, fructus forsythiae, herba Typhonii gigantei and 50000g of water, extracting at 120 deg.C for 30min, and filtering to obtain 30000mL of first extractive solution and 12g of residue; mixing 12g of dregs of a decoction with 12mL of water, extracting at 60-65 ℃ for 20min, filtering to obtain 7.2mL of second extracting solution, combining the first extracting solution and the second extracting solution, and cooling to about 60 ℃ to obtain a traditional Chinese medicine extract;
3. mixing 1.16g of povidone iodine powder and 98g of water which is burnt to 80 ℃, and stirring to obtain an iodine solution;
4. mixing 1.3g of chlorhexidine acetate with 98g of water which is heated to 100 ℃, and stirring to obtain a chlorhexidine acetate solution;
5. and (3) putting the iodine solution and the chlorhexidine acetate solution obtained in the steps (3) and (4) into the traditional Chinese medicine extract obtained in the step (2), and continuously stirring until the mixture is completely removed to obtain the compound iodine disinfectant.
Test example 1
1. The compound iodine disinfectant obtained in example 1 is sent to zhong ding detection technology limited company in Guangdong province, and the killing effect of the compound iodine disinfectant obtained in example 1 on escherichia coli, staphylococcus aureus and candida albicans is detected, and the result is shown in fig. 1 and fig. 2, wherein the "medical compound iodine disinfectant" is the compound iodine disinfectant in example 1 of the present invention. As can be seen from figures 1 and 2, the composite iodine disinfectant has a killing rate of 99.99% for staphylococcus aureus, escherichia coli and candida albicans in the environment.
2. The complex iodine disinfectant obtained in example 1 was sent to Kery college for neutralizer identification (the virus to be killed was human coronavirus HC0V-229E, and the host cell of human coronavirus HC0V-229E was MRC-5 cell), and the results are shown in FIG. 3. As can be seen from FIG. 3, the virus inactivation rate of the compound iodine disinfectant is as high as 94.98%.
3. The compound iodine disinfectant obtained in example 1 was sent to the Kery institute for toxicity testing, and the results are shown in FIG. 4. Wherein, the "medical compound iodine disinfectant" in fig. 4 is the compound iodine disinfectant of embodiment 1 of the present invention. As can be seen from figure 4, the compound iodine disinfectant disclosed by the invention is an actual non-toxic substance, and is safe and reliable.
According to the embodiment, the compound iodine disinfectant has the killing rate of 99.99% on staphylococcus aureus, escherichia coli and candida albicans in the environment, can break the cell wall of human coronavirus HC0V-229E mycoplasma, enhances the resistance to virus infection, has the inactivation rate of 94.98% on HC0V-229E virus, is practically non-toxic, and can be safely used.
Although the present invention has been described in detail with reference to the above embodiments, it is only a part of the embodiments of the present invention, not all of the embodiments, and other embodiments can be obtained without inventive step according to the embodiments, and the embodiments are within the scope of the present invention.
Claims (10)
1. The compound iodine disinfectant is characterized in that raw materials of the compound iodine disinfectant comprise traditional Chinese medicine components and chemical components;
the traditional Chinese medicine components comprise barbed skullcap herb, herba houttuyniae, weeping forsythia and typhonium giganteum;
the chemical components include iodine and chlorhexidine acetate.
2. The compound iodine disinfectant as claimed in claim 1, wherein the mass ratio of the traditional Chinese medicine components to the chemical components is 30 (2.42-2.50).
3. The compound iodine disinfectant as claimed in claim 1 or 2, wherein the mass ratio of the sculellaria barbata, the herba houttuyniae, the fructus forsythiae and the typhonium giganteum is 3; the mass ratio of the iodine to the chlorhexidine acetate is (1.14-1.18): (1.28-1.32).
4. The method for preparing a complex iodine disinfectant as claimed in any one of claims 1 to 3, comprising the steps of:
mixing and extracting the barbed skullcap herb, the herba houttuyniae, the weeping forsythia capsule, the typhonium giganteum and water to obtain a traditional Chinese medicine extract;
mixing the iodine with water to obtain an iodine solution;
mixing the chlorhexidine acetate with water to obtain a chlorhexidine acetate solution;
and mixing the traditional Chinese medicine extract, an iodine solution and a chlorhexidine acetate solution to obtain the compound iodine disinfectant.
5. The method of claim 4, wherein the mixed extraction comprises a first extraction and a second extraction;
the temperature of the first extraction is 120 ℃, and the time of the first extraction is 30min;
the temperature of the second extraction is 60-65 ℃, and the time of the second extraction is 20min.
6. The preparation method according to claim 5, wherein the mass sum of the barbat skullcap, the herba houttuyniae, the forsythia suspense and the typhonium giganteum to water ratio at the time of the first extraction is 3.
7. The method of claim 6, further comprising, after the mixing and extracting: cooling the obtained extractive solution to 60 deg.C to obtain the Chinese medicinal extract.
8. The production method according to claim 4, wherein the iodine solution is produced such that the ratio of iodine to water by mass is 1.16.
9. The method according to claim 4, wherein the mass ratio of chlorhexidine acetate to water is 1.3.
10. The use of the complex iodine disinfectant solution according to any one of claims 1 to 3 or the complex iodine disinfectant solution obtained by the production method according to any one of claims 4 to 9 in medical care and health care.
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| CN104523748A (en) * | 2015-01-05 | 2015-04-22 | 四川悦康源通药业有限公司 | Compound iodine disinfectant and preparation method and application thereof |
| CN104920499A (en) * | 2015-05-15 | 2015-09-23 | 金维元 | Compound disinfectant, and preparation method and application thereof |
| CN105663704A (en) * | 2016-01-25 | 2016-06-15 | 上海安信生物医药技术有限公司 | Skin mucosa and wound disinfectant |
| CN107929723A (en) * | 2017-12-11 | 2018-04-20 | 成都顺发消洗科技有限公司 | A kind of Chinese herbal medicine skin antiseptic |
| CN111345288A (en) * | 2020-03-12 | 2020-06-30 | 优仕康生（天津）科技发展有限公司 | A colloidal carrier capable of forming antibacterial and antiviral coating on the surface of respiratory protector, colloidal tincture and application thereof |
| CN111544540A (en) * | 2020-04-26 | 2020-08-18 | 佛山市爱庭电器有限公司 | Medicine for resisting novel coronavirus, preparation method and application thereof |
-
2022
- 2022-09-06 CN CN202211085568.9A patent/CN115844967B/en active Active
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104523748A (en) * | 2015-01-05 | 2015-04-22 | 四川悦康源通药业有限公司 | Compound iodine disinfectant and preparation method and application thereof |
| CN104920499A (en) * | 2015-05-15 | 2015-09-23 | 金维元 | Compound disinfectant, and preparation method and application thereof |
| CN105663704A (en) * | 2016-01-25 | 2016-06-15 | 上海安信生物医药技术有限公司 | Skin mucosa and wound disinfectant |
| CN107929723A (en) * | 2017-12-11 | 2018-04-20 | 成都顺发消洗科技有限公司 | A kind of Chinese herbal medicine skin antiseptic |
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| CN111544540A (en) * | 2020-04-26 | 2020-08-18 | 佛山市爱庭电器有限公司 | Medicine for resisting novel coronavirus, preparation method and application thereof |
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