CN115844742A - Moisturizing composition, preparation method thereof and cosmetic - Google Patents
Moisturizing composition, preparation method thereof and cosmetic Download PDFInfo
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- CN115844742A CN115844742A CN202211502956.2A CN202211502956A CN115844742A CN 115844742 A CN115844742 A CN 115844742A CN 202211502956 A CN202211502956 A CN 202211502956A CN 115844742 A CN115844742 A CN 115844742A
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Abstract
The invention discloses a moisturizing composition, a preparation method thereof and cosmetics, and relates to the technical field of cosmetics, wherein the moisturizing composition comprises, by mass, 5-15% of spirulina platensis extract, 0.5-5% of madecassoside, 10-25% of saccharide isomer and 55-80% of polyhydric alcohol. The moisturizing composition provided by the application is prepared by introducing the spirulina platensis extract, and mixing the spirulina platensis extract, madecassoside, saccharide isomerate and polyhydric alcohol according to a specific ratio, so that an excellent moisturizing effect can be obtained, and the moisturizing composition is suitable for people with hypersensitive dry skin. The preparation method is simple and easy to implement, the raw materials are easy to obtain, and the preparation method is suitable for mass production. The moisturizing composition can be added into cosmetic to improve moisturizing effect of cosmetic.
Description
Technical Field
The invention relates to the technical field of cosmetics, and particularly relates to a moisturizing composition, a preparation method thereof and a cosmetic.
Background
The stratum corneum of the skin lacks water, and normal metabolism of keratinocytes is abnormal, so that the keratinocytes excessively adhere to the surface of the skin, and the skin is dry, rough, low in elasticity, dull, tight and uncomfortable and has a series of problems. The research on how to keep the moisture content of the horny layer, improve the water retention capacity of the skin and maintain the health state of the skin has important significance on the capability of the skin to resist external stimulation. The moisturizer can increase the hydration of the skin and keep the skin smooth and moist, and the moisturizing effects and mechanisms of the moisturizers with different components are different. For sensitive dry skin, the moisture retention performance of the skin is obviously reduced, and the skin is urgently needed to be quickly helped to improve the dry state of the skin. However, the existing humectant has a single moisturizing effect and can meet the skin requirements of people with allergic dryness.
In view of this, the invention is particularly proposed.
Disclosure of Invention
The invention aims to provide a moisturizing composition which has an excellent moisturizing effect and is suitable for people with allergic dry skin.
The invention aims to provide a preparation method of a moisturizing composition, which is simple and easy to operate.
The purpose of the present invention is to provide a cosmetic which has excellent moisturizing effects.
The invention is realized by the following steps:
in a first aspect, the present invention provides a moisturizing composition comprising, by mass, 5-15% of spirulina platensis extract, 0.5-5% of madecassoside, 10-25% of saccharide isomers, and 55-80% of polyhydric alcohol.
In an alternative embodiment, the composition comprises, in mass percent, 6-15% of Spirulina platensis extract, 0.6-5% of madecassoside, 12-25% of saccharide isomers, and 60-80% of polyhydric alcohol.
In alternative embodiments, the ratio of the amount of Spirulina platensis extract, the madecassoside, the saccharide isomer, and the polyol is 1 (0.03-1): 0.67-5): 3.67-16, preferably 1 (0.1-1): 0.9-5): 4-14, more preferably 1 (0.2-1): 1-5): 5-14.
In an alternative embodiment, the spirulina platensis extract is prepared by the following steps: pulverizing dried Spirulina platensis, adding 8-12 times of water, adjusting pH to 10-11, performing ultrasonic extraction at 70-80 deg.C under microwave power of 500-700W for 30-60min, centrifuging, collecting supernatant, adding 4-6 times of water, adjusting pH, performing microwave ultrasonic extraction for 20-40min, mixing the supernatants 2 times, adjusting pH to 7, adding trichloroacetic acid to remove protein, adding 4-6 times of anhydrous ethanol to precipitate, washing with acetone, and freeze drying to obtain Spirulina platensis extract.
In alternative embodiments, the polyol comprises one or more of 1, 3-propanediol, butanediol, and 1, 2-pentanediol.
In an alternative embodiment, the saccharide isomer is lodestone.
In a second aspect, the present invention provides a method of preparing a moisturizing composition according to any one of the preceding embodiments, comprising mixing the components of the moisturizing composition uniformly.
In a third aspect, the present invention provides a cosmetic product comprising a moisturizing composition as described in any of the preceding embodiments.
In an alternative embodiment, the moisturizing composition is added in an amount of 1 to 10%, preferably 2 to 10%, by weight of the cosmetic.
In alternative embodiments, the cosmetic product comprises at least one of a lotion, a mask, a lotion, a serum, a cream, a face cleanser, a sun block, and a suntan lotion.
The invention has the following beneficial effects:
the moisturizing composition provided by the application is prepared by introducing the spirulina platensis extract, mixing the spirulina platensis extract with madecassoside, saccharide isomerous bodies and polyhydric alcohols according to a specific ratio, wherein the spirulina platensis extract contains rich polysaccharides and is beneficial to improving the water retention capacity of skin, the madecassoside can reduce desquamation of the skin, excessive proliferation of keratinocytes can be effectively prevented, synthesis of matrix metalloproteinase-1 is reduced, generation of collagen I is promoted, skin discomfort is improved, the saccharide isomerous bodies can promote combination of natural moisturizing factors NMF and hyaluronic acid, skin moisturizing capacity is improved, the polyhydric alcohols can prevent moisture loss of skin stratum corneum and can absorb moisture in air, and moisturizing skin is realized. The preparation method is simple and easy to implement, the raw materials are easy to obtain, and the preparation method is suitable for mass production. The moisturizing composition can be added into cosmetic to improve moisturizing effect of cosmetic.
Detailed Description
In order to make the objects, technical solutions and advantages of the embodiments of the present invention more apparent, the technical solutions of the embodiments of the present invention will be clearly and completely described below. The examples, in which specific conditions are not specified, were carried out according to conventional conditions or conditions recommended by the manufacturer. The reagents or instruments used are not indicated by the manufacturer, and are all conventional products available commercially.
Various exemplary embodiments, features and aspects of the invention will be described in detail below. The word "exemplary" is used exclusively herein to mean "serving as an example, embodiment, or illustration. Any embodiment described herein as "exemplary" is not necessarily to be construed as preferred or advantageous over other embodiments.
Furthermore, in the following detailed description, numerous specific details are set forth in order to provide a better understanding of the present invention. It will be understood by those skilled in the art that the present invention may be practiced without some of these specific details. In other instances, methods, means, devices and steps which are well known to those skilled in the art have not been described in detail so as not to obscure the invention.
All units used in the specification are international standard units unless otherwise stated, and numerical values and numerical ranges appearing in the present invention should be understood to include systematic errors inevitable in industrial production.
In the present specification, "%" denotes mass% unless otherwise specified.
In the present specification, the meaning of "may" includes both the meaning of performing a certain process and the meaning of not performing a certain process.
In the present specification, reference to "some particular/preferred embodiments," "other particular/preferred embodiments," "embodiments," and the like, means that a particular element (e.g., feature, structure, property, and/or characteristic) described in connection with the embodiment is included in at least one embodiment described herein, and may or may not be present in other embodiments. In addition, it is to be understood that the described elements may be combined in any suitable manner in the various embodiments.
In the present specification, the numerical range represented by "numerical value a to numerical value B" means a range including the end points of numerical values a and B.
In the present specification, the "normal temperature" and "room temperature" may be 10 to 40 ℃.
In the present specification, the term "water" includes any available water that can be used in the cosmetic field, such as deionized water, distilled water, ion-exchanged water, double distilled water, high purity water, and purified water.
The invention provides a moisturizing composition, which comprises the components of spirulina platensis extract, madecassoside, saccharide isomerate and polyhydric alcohol; the adding amount of the spirulina platensis extract is 5-15% of the total mass of the moisturizing composition; the addition amount of madecassoside is 0.5-5%, the addition amount of saccharide isomer is 10-25%, and the addition amount of polyalcohol is 55-80%. Preferably, the spirulina platensis extract is added in an amount of 6-15% by mass of the total moisturizing composition; the addition amount of madecassoside is 0.6-5%, the addition amount of saccharide isomer is 12-25%, and the addition amount of polyalcohol is 60-80%.
In the moisturizing composition, the spirulina platensis extract has the effects of moisturizing and reducing the transepidermal water loss of the skin. The madecassoside has the effects of improving skin desquamation, reducing excessive differentiation of keratinocytes, smoothing and smoothing skin, improving skin tolerance and reducing skin dryness and itching discomfort. The saccharide isomerate can effectively improve the roughness of the skin, lock water for a long time, preserve moisture, strengthen the capability of the skin for resisting external stimulation and improve the feeling of tightness and discomfort of the skin. The polyhydric alcohol can effectively moisten skin. The moisturizing composition disclosed by the invention has an excellent moisturizing effect through the synergistic effect of various active ingredients, improves the skin barrier capability, effectively improves the skin discomfort, and is suitable for people with hypersensitive dry skin.
Furthermore, the content ratio of the spirulina platensis extract, the madecassoside, the saccharide isomer and the polyalcohol in the moisturizing composition is 1 (0.03-1): (0.67-5): (3.67-16). When the content ratio of the spirulina platensis extract to the madecassoside to the saccharide isomerous body to the polyhydric alcohol is 1 (0.03-1) to (0.67-5) to (3.67-16), the synergistic effect can be further achieved, the moisturizing effect is good, and the skin barrier capability is obviously improved. Specifically, the content ratio of Spirulina platensis extract, madecassoside, saccharide isomerate and polyhydric alcohol may be 1 (0.1-1): 0.9-5): 4-14, more preferably 1 (0.2-1): 1-5): 5-14, still more preferably 1 (0.2-0.8): 1-4.5): 5-12, still more preferably 1 (0.3-0.5): 1-4): 5-10.
Specifically, the specific description of each component of the present application is as follows:
(1) Spirulina platensis extract
The Spirulina platensis in the moisturizing composition is a Spirulina (Spirulina platensis) H11 strain, and the Spirulina (Spirulina platensis) H11 strain is deposited in the Chinese type culture collection on 2017, 12 and 8 months, and the address is as follows: wuhan, wuhan university; the preservation number of the preservation center is: CCTCC NO: and M2017772. The classification of the Spirulina strain H11 is named as Spirulina platensis SCSIO-44012-H11. In the present application, spirulina platensis extract contains abundant polysaccharides, and contributes to the enhancement of the water retention capacity of skin.
The preparation method of Spirulina platensis extract comprises: pulverizing dried Spirulina platensis, adding 8-12 times of water, adjusting pH to 10-11, performing ultrasonic extraction at 70-80 deg.C under 500-700W of microwave power for 30-60min, centrifuging, collecting supernatant, adding 4-6 times of water into the precipitate, performing microwave ultrasonic extraction for 20-40min, mixing the supernatants 2 times, adjusting pH to 7, adding trichloroacetic acid to remove protein, adding 4-6 times of anhydrous ethanol to precipitate, washing with acetone, freeze drying, and dissolving with 85% butanediol solution 9 times of the weight of the solution to obtain Spirulina platensis extract.
The spirulina platensis extract is added in an amount of 5-15%, preferably 6-15%, based on the total mass of the moisturizing composition, for example: may be 6%, 8%, 10%, 12%, 14%, etc. When the addition amount of the spirulina platensis extract is 5-15%, the spirulina platensis extract has a good moisturizing effect and can effectively reduce the water loss of the skin through epidermis.
(2) Madecassoside
The madecassoside in the moisturizing composition is white powder, has the effect of reducing skin desquamation, effectively prevents excessive proliferation of keratinocytes, reduces synthesis of matrix metalloproteinase-1, promotes generation of collagen I, and accordingly improves skin discomfort. The madecassoside of the invention can be obtained by commercial purchase or extraction preparation.
The madecassoside is added in an amount of 0.5 to 5%, preferably 0.6 to 5%, based on the total mass of the moisturizing composition, for example: may be 0.8%, 1%, 2%, 3%, 4%, 4.5%. The madecassoside with the addition amount of 0.5-5% is helpful for improving the dry state of the skin, reducing the excessive proliferation of keratinocytes and effectively improving the comfortable feeling of the skin.
(3) Saccharide isomerate
The saccharide isomer (pentaavitin) in the moisturizing composition of the present invention is derived from plant D-glucose, and contains glucose, fructose, mannose, galactose, psicose, and other components. The addition of saccharide isomerate can improve the expression level of Loricrin (Loricrin) gene and influence the function of cornified envelope; can also improve the expression level of acid sphingomyelinase gene and stimulate the synthesis of ceramide; can improve the gene expression level of filaggrin and hyaluronic acid synthetase 3, promote the combination of natural moisturizing factor NMF and hyaluronic acid, and thus improve the skin water retention capacity.
In addition, because carbonyl in the sugar structure of the saccharide isomer is combined with amino in the skin keratin, the saccharide isomer is tightly connected with the keratin and is not easy to wash off, and the saccharide isomer can be removed only when the skin stratum corneum naturally falls off, so that the saccharide isomer can play deep water locking and water retaining functions for a long time, thereby improving the skin roughness for a long time and relieving skin irritation and discomfort caused by the falling of the keratin or the external environment.
The moisturizing composition according to the present invention may include saccharide isomers in an amount of 10 to 25% by weight, preferably 12 to 25% by weight of the moisturizing composition. When the addition amount of the saccharide isomerate is between 10 and 25 percent, the cosmetic can moisturize and moisturize, and simultaneously can effectively improve skin texture and keep the skin to have good moisture.
Preferably, the saccharide isomer in the present application is lodestone.
(4) Polyhydric alcohols
The polyhydric alcohol in the moisturizing composition of the present invention moisturizes the skin by utilizing the hydrophilicity and hygroscopicity of the hydroxyl group, is highly safe and easily available, can prevent the loss of moisture in the stratum corneum of the skin, and can absorb moisture in the air to moisturize the skin.
The moisturizing composition according to the present invention comprises the polyol in an amount of 55 to 80%, preferably 60 to 80%, by weight of the moisturizing composition. When the addition amount of the polyhydric alcohol is between 55 and 80%, preferably between 60 and 80%, it helps dispersion and dissolution of other components in the cosmetic, and promotes absorption of nutrients and moisture by the skin, thereby better maintaining skin moisturization.
According to the moisturizing composition of the present invention, the polyhydric alcohol includes one or more of 1, 3-propanediol, butanediol, and 1, 2-pentanediol. Wherein, the 1, 3-propylene glycol is a natural product and can not cause skin irritation or allergy. Butanediol is a common small molecule moisturizing ingredient. The 1, 2-pentanediol is helpful for moisturizing the skin. When the addition amount of the polyhydric alcohol is 55-80%, the moisture content of the skin can be improved, the addition of the preservative in the cosmetic can be reduced, and the skin irritation caused by the preservative can be reduced, so that the skin care product is suitable for nursing sensitive and dry skin.
The features and properties of the present invention are described in further detail below with reference to examples.
The application provides a preparation method of a spirulina platensis extract, which comprises the following steps: pulverizing dried Spirulina platensis (Spirulina platensis) H11 strain, adding 10 times of water, adjusting pH to 10-11, performing ultrasonic extraction at 70-80 deg.C under microwave power of 600W for 45min, centrifuging, collecting supernatant, adding 5 times of water into the precipitate, adjusting pH, performing microwave ultrasonic extraction for 30min, mixing 2 times of supernatant, adjusting pH to 7, adding 2wt% trichloroacetic acid deproteinization, adding 5 times of anhydrous ethanol for precipitation, washing with acetone, and freeze drying to obtain Spirulina platensis extract.
The spirulina platensis extracts used in all the subsequent examples and comparative examples are obtained by adopting the method for extraction.
Example 1
This example provides a moisturizing composition, wherein the amount of spirulina platensis extract added is 5%, the amount of madecassoside added is 0.5%, the amount of lodestone is 25%, and the amount of 1, 3-propanediol added is 69.5%, by mass%. The preparation method comprises the following steps: mixing Spirulina platensis extract, madecassoside, lodestone and 1, 3-propylene glycol at room temperature, stirring to dissolve completely to obtain moisturizing composition I.
Example 2
This example provides a moisturizing composition, which includes, by mass, 15% of spirulina platensis extract, 2% of madecassoside, 15% of lodestone, and 68% of butylene glycol. The preparation method comprises the following steps: mixing Spirulina platensis extract, madecassoside, lodestone and butanediol at room temperature, stirring to dissolve completely, and making into moisturizing composition II.
Example 3
This example provides a moisturizing composition, wherein the amount of spirulina platensis extract added is 10%, the amount of madecassoside added is 5%, the amount of lodestone added is 25%, and the amount of 1, 2-pentanediol added is 60%, by mass%. The preparation method comprises the following steps: mixing Spirulina platensis extract, madecassoside, lodestone and 1, 2-pentanediol at room temperature, stirring well to dissolve completely to obtain moisturizing composition III.
Example 4
This example provides a moisturizing composition, wherein the amount of spirulina platensis extract added is 5%, the amount of madecassoside added is 5%, the amount of lodestone added is 10%, the amount of butylene glycol added is 60%, and the amount of 1, 3-propylene glycol added is 20% by weight. The preparation method comprises the following steps: mixing Spirulina platensis extract, madecassoside, lodestone, butanediol and 1, 3-propylene glycol at room temperature, stirring to dissolve completely to obtain moisturizing composition IV.
Example 5
This example provides a moisturizing composition, which includes, by mass, 8% of spirulina platensis extract, 2% of madecassoside, 12% of lodestone, 5% of 1, 2-pentanediol, and 73% of butylene glycol. The preparation method comprises the following steps: mixing Spirulina platensis extract, madecassoside, lodestone, 1, 2-pentanediol and butanediol at room temperature, stirring to dissolve completely, and making into moisturizing composition V.
Comparative example 1
This comparative example provides a moisturizing composition that is substantially the same as example 1 except that the water-blocking magnetite is omitted and the same amount of water is replenished.
Specifically, the adding amount of the spirulina platensis extract is 5 percent, the adding amount of the madecassoside is 0.5 percent, the adding amount of the 1, 3-propylene glycol is 69.5 percent and the balance is water in percentage by mass. The preparation method comprises the following steps: mixing Spirulina platensis extract, madecassoside, 1, 3-propylene glycol and water at room temperature, stirring to dissolve completely to obtain moisturizing composition VI.
Comparative example 2
This comparative example provides a moisturizing composition that is essentially the same as example 2, except that the comparative example omits madecassoside and is supplemented with the same amount of water.
Specifically, the adding amount of the spirulina platensis extract is 15 percent, the adding amount of the water locking magnetite is 15 percent, the adding amount of the butanediol is 68 percent, and the balance of water are calculated by mass percent. The preparation method comprises the following steps: mixing Spirulina platensis extract, lodestone, butanediol and water at room temperature, stirring to dissolve completely to obtain moisturizing composition VII.
Comparative example 3
This comparative example provides a moisturizing composition that is substantially the same as example 2, except that it has a reduced amount of butylene glycol added and is replenished with the same amount of water.
Specifically, the adding amount of the spirulina platensis extract is 15 percent, the adding amount of the madecassoside is 2 percent, the adding amount of the lodestone is 15 percent, the adding amount of the butanediol is 40 percent, and the balance is water. The preparation method comprises the following steps: mixing Spirulina platensis extract, madecassoside, lodestone, butanediol and water at room temperature, stirring to dissolve completely to obtain moisturizing composition VIII.
Comparative example 4
This comparative example provides a moisturizing composition that is substantially the same as example 3, except that this comparative example omits the Spirulina platensis extract and replenishes with the same amount of water.
Specifically, the adding amount of the madecassoside is 5 percent, the adding amount of the water-locking magnetite is 25 percent, the adding amount of the 1, 2-pentanediol is 60 percent, and the balance is water. The preparation method comprises the following steps: mixing madecassoside, lodestone, 1, 2-pentanediol and water at normal temperature, and stirring uniformly until completely dissolved to obtain the moisturizing composition IX.
Comparative example 5
This comparative example provides a moisturizing composition that is substantially the same as example 4, except that the comparative example increases the amount of added Spirulina platensis extract and correspondingly decreases the amount of added butanediol.
Specifically, the adding amount of the spirulina platensis extract is 25%, the adding amount of the madecassoside is 5%, the adding amount of the lodestone is 10%, the adding amount of the butanediol is 40%, and the adding amount of the 1, 3-propanediol is 20% by mass percentage. The preparation method comprises the following steps: mixing Spirulina platensis extract, madecassoside, lodestone Magnetitum, butanediol and 1, 3-propylene glycol at room temperature, stirring to dissolve completely, and making into moisturizing composition X.
Comparative example 6
This comparative example provides a moisturizing composition that is substantially the same as example 5, except that the comparative example increases the amount of madecassoside and correspondingly decreases the amount of added butylene glycol.
Specifically, the addition amount of the spirulina platensis extract is 8 percent, the addition amount of the madecassoside is 10 percent, the addition amount of the lodestone is 12 percent, the addition amount of the 1, 2-pentanediol is 5 percent, and the addition amount of the butanediol is 65 percent by mass percent. The preparation method comprises the following steps: mixing Spirulina platensis extract, madecassoside, lodestone, 1, 2-pentanediol and butanediol at room temperature, stirring to dissolve completely to obtain moisturizing composition XI.
Comparative example 7
This comparative example provides a moisturizing composition that is substantially the same as example 3, except that it increases the amount of water-blocking magnetite and correspondingly decreases the amount of 1, 2-pentanediol added.
Specifically, the adding amount of the spirulina platensis extract is 10 percent, the adding amount of the madecassoside is 5 percent, the adding amount of the lodestone is 30 percent, and the adding amount of the 1, 2-pentanediol is 55 percent by mass percent. The preparation method comprises the following steps: mixing Spirulina platensis extract, madecassoside, lodestone and 1, 2-pentanediol at room temperature, stirring well to dissolve completely to obtain moisturizing composition XII.
Comparative example 8
The present comparative example provides a moisturizing composition comprising only spirulina platensis extract, wherein the spirulina platensis extract is added in an amount of 10% and water is added in an amount of 90%, and the preparation method comprises: and mixing the spirulina platensis extract with water at normal temperature, and uniformly stirring until the spirulina platensis extract is completely dissolved to prepare the moisturizing composition XIII.
Comparative example 9
This comparative example provides a moisturizing composition that is substantially the same as example 3, except that in this comparative example the Spirulina platensis extract is replaced with a hydrolyzed Red algae extract.
Specifically, the addition amount of the hydrolyzed red algae extract is 10 percent, the addition amount of the madecassoside is 5 percent, the addition amount of the lodestone is 25 percent, and the addition amount of the 1, 2-pentanediol is 60 percent by mass percent. The preparation method comprises the following steps: mixing hydrolyzed red algae extract, madecassoside, lodestone and 1, 2-pentanediol at room temperature, stirring well to dissolve completely to obtain moisturizing composition XIV.
Comparative example 10
This comparative example provides a moisturizing composition that is substantially the same as example 3 except that the Spirulina platensis extract (Spirulina H11) was replaced with a wild Spirulina platensis extract in this comparative example, which was extracted in the same manner as the Spirulina platensis extract.
Specifically, the addition amount of the wild spirulina platensis extract is 10%, the addition amount of the madecassoside is 5%, the addition amount of the lodestone is 25%, and the addition amount of the 1, 2-pentanediol is 60% in percentage by mass. The preparation method comprises the following steps: mixing wild Spirulina platensis extract, madecassoside, lodestone and 1, 2-pentanediol at room temperature, stirring to dissolve completely, and making into moisturizing composition XV.
1. Test of moisturizing Effect
0.5g each of the hydrophilic sponge pieces was weighed, 10g of an 8% aqueous solution containing the moisturizing compositions I to V of examples 1 to 5 and the moisturizing compositions VI to XV of comparative examples 1 to 10 was added thereto, and the mixture was spread in a 10 cm-size open glass plate with deionized water as a blank, 3 samples of each sample were paralleled and placed in a constant temperature and humidity cabinet at 48 ℃ and 25% humidity for drying for 6 hours and weighing, and the weight change of moisture before and after drying of the sponge pieces was compared as shown in Table 1. The larger the change in moisture is, the poorer the moisturizing effect of the moisturizing composition is, and the smaller the change in moisture is, the better the moisturizing effect of the moisturizing composition is.
TABLE 1 moisturizing composition I-XV moisturizing Effect test
As can be seen from Table 1, the moisturizing compositions I to V of examples 1 to 5 and the moisturizing compositions VI to XV of comparative examples 1 to 10 all had a certain moisturizing effect as compared with the blank control. That is, the spirulina platensis extract, the madecassoside, the lodestone and the polyalcohol can play a good moisturizing effect within the scope of the invention.
Compared with example 1, comparative example 1 without the water-locking magnet has a significantly higher moisture change rate than example 1, i.e., moisturizing composition VI has a significantly poorer moisturizing effect than moisturizing composition I.
Compared with example 2, comparative example 2 has slightly lower moisturizing effect of moisturizing composition VII than moisturizing composition II because no madecassoside is added. In comparison with example 2, in comparative example 3, the moisturizing effect of the moisturizing composition VIII was reduced as compared with that of the moisturizing composition II due to the decrease in the amount of the polyol.
The moisturizing composition IX of comparative example 4 also did not exhibit the same moisturizing effect as the moisturizing composition III, as compared to example 3, due to the absence of the spirulina platensis extract.
The moisturizing composition IX of comparative example 5 was slightly superior in moisturizing effect to moisturizing composition IV due to an excessive amount of spirulina platensis extract compared to example 4. Namely, the spirulina platensis extract of the invention has excellent moisturizing effect.
Comparative example 6 added madecassoside in excess compared to example 5, although moisturizing composition XI had slightly better moisturizing effect than moisturizing composition V, the more the amount used increased the cost of the cosmetic formulation.
Compared with the example 3, the comparison example 7 has the advantages that the number of the used water locking magnets is increased, and the moisturizing effect of the moisturizing composition XII is obviously better than that of the moisturizing composition III; however, as the addition amount of the water-locking magnet is increased, the color is dark and the skin feel is sticky when the water-locking magnet is added into the cosmetics.
Comparative example 8 compared with example 3, only the spirulina platensis extract alone has a moisturizing effect, but the moisturizing effect of the moisturizing composition XIII is obviously inferior to that of the spirulina platensis extract, madecassoside, lodestone and polyhydric alcohol in the synergistic effect.
Comparative examples 9 and 10 compared with example 3, using hydrolyzed red algae extract and wild spirulina platensis extract, respectively, moisturizing compositions XIV and XV, although having better moisturizing effect, were not as effective as moisturizing composition III, meaning that the moisturizing effect of the spirulina platensis extract of the present invention was superior using the same amount of two different algae extracts.
Preparation of moisturizing lotions I to XV of application examples 1 to 5 and comparative examples 1 to 10
The moisturizing compositions I to V of examples 1 to 5 and the moisturizing compositions VI to XV of comparative examples 1 to 10 were added to the base formula of the cosmetic water of Table 2 at a concentration of 5% in accordance with the mass percentages of the components in Table 2, to prepare corresponding moisturizing lotions I to XV, respectively, using the lotion without the moisturizing composition as a blank sample.
The preparation method of each moisturizing lotion comprises the following steps:
1) Adding deionized water into an emulsifying pot, sequentially adding EDTA disodium, allantoin, xanthan gum, diglycerin, methyl hydroxybenzoate and acryloyl dimethyl ammonium taurate/VP copolymer, homogenizing at high speed for 3min, heating to 80-85 deg.C, holding the temperature for 20min, and stirring to dissolve completely.
2) Cooling to 45 deg.C with cooling water, adding PEG/PPG-14/7 dimethyl ether, phenoxyethanol and moisturizing composition I-XV, stirring thoroughly to mix well, cooling to 38 deg.C, inspecting, discharging, and respectively preparing corresponding moisturizing lotion I-XV.
TABLE 2 moisturizing lotions I-XV formulations
| Raw material components | Cosmetic water base formulation (%) |
| Deionized water | Is added to 100 |
| EDTA disodium salt | 0.02 |
| Allantoin | 0.01 |
| Xanthan gum | 0.03 |
| Diglycerol | 2 |
| Hydroxy benzene methyl ester | 0.15 |
| Acryloyldimethyl ammonium taurate/VP copolymer | 0.05 |
| PEG/PPG-14/7 dimethyl Ether | 1.5 |
| Phenoxyethanol | 0.5 |
| Moisturizing compositions I-XV | 5 |
Test for transepidermal Water loss (TEWL) of skin
Skin water loss reflects how well the skin's barrier function is, the better the skin barrier function the less water loss. 80 healthy volunteers were screened, and subjects were positive for skin after 10% lactic acid sting (judged as sensitive skin). The subjects were randomly divided into 16 groups, and 5 subjects per sample were randomized, and each of the moisturizing lotions I-XV and the blank lotion was applied 1 time in the morning and at the evening for 2 weeks. The TEWL values of selected areas of the face were measured using a transepidermal water tester, tewameter TM300, at week 0, week 1 and week 2, and 3 measurements were averaged for each area, and the results of the change in transepidermal water loss of the skin are shown in Table 3. As can be seen from Table 3, a smaller TEWL value indicates less transepidermal water loss in the skin; the greater the reduction at week 1 and week 2, respectively, compared to week 0, the better the skin water retention function.
TABLE 3 TEWL test results for moisturizing lotions I-XV
As can be seen from Table 3, the moisturizing lotions I-V of examples 1-5 and VI-XV of comparative examples 1-10 both helped the skin reduce transepidermal water loss compared to the blank control at week 1 and week 2, respectively, compared to week 0. Namely, the spirulina platensis extract, the madecassoside, the lodestone and the polyalcohol can play a good role in reducing the water loss of the skin within the scope of the invention.
Compared with the example 1, the comparative example 1 is not added with the water-locking magnet, and the change of the moisture loss value of the skin through the epidermis is obviously smaller than that of the example 1, namely, the effect of the moisturizing lotion VI on reducing the moisture loss of the skin is obviously inferior to that of the moisturizing lotion I.
Compared with example 2, comparative example 2 has slightly poorer skin moisture loss reducing ability than moisturizing lotion II because madecassoside is not added, and comparative example 3 has slightly poorer skin moisture loss reducing ability than moisturizing lotion VII and VIII because polyhydric alcohol is reduced.
Comparative example 4 shows improvement in transepidermal water loss of skin without adding the Spirulina platensis extract as compared with example 3, but the effect of improvement upon continuous use is not as significant as that of example 3.
The comparative example 5 exerts a better effect of reducing the water loss of the skin through the epidermis than the example 4 due to the excessive amount of the spirulina platensis extract, and simultaneously exerts a better effect of continuously improving the use, that is, the spirulina platensis extract of the present invention has an excellent effect of reducing the water loss of the skin, but the cost of the cosmetic formulation is increased.
Comparative example 6 added madecassoside in excess compared to example 5, although its ability to reduce skin moisture loss was improved, the more madecassoside was used to increase the cost of the cosmetic formulation.
Compared with the example 3, the water-locking magnet used in the comparative example 7 is increased, and the effect of reducing the skin water loss of the moisturizing lotion XII is obviously better than that of the moisturizing composition III; however, as the addition amount of the water-locking magnet is increased, the color of the water-locking magnet added into the cosmetic is darker, and meanwhile, the compatibility in the formula needs to be paid attention.
Comparative example 8 compared to example 3, only using the spirulina platensis extract alone can help reduce the water loss through the skin well, but the moisturizing lotion XIII has a significantly lower moisturizing effect than the moisturizing effect of the synergistic effect of the spirulina platensis extract, madecassoside, lodestone and polyhydric alcohol of the present invention.
Comparative example 9 and comparative example 10 compared to example 3, using hydrolyzed red algae extract and wild spirulina platensis extract, respectively, moisturizing lotions XIV and XV, although having better water retention effects, were both less effective than moisturizing lotion III, meaning that the spirulina platensis extract of the present invention had superior water retention, i.e., superior ability to help reduce transepidermal water loss, using the same amount of two different algae extracts.
Preparation of moisturizing body milk Using examples 1-5 and comparative examples 1-7
The moisturizing compositions I-V of examples 1 to 5 and the moisturizing compositions VI-XII of comparative examples 1 to 7 were added to the moisturizing body milk base formula of Table 4 at a concentration of 2% according to the mass percentages of the components in Table 4 to prepare corresponding moisturizing body milks I-V and VI-XII, respectively, and the body milk without the moisturizing composition was used as a blank control.
The preparation method of each moisturizing body milk comprises the following steps:
1) Adding deionized water into an emulsifying pot, sequentially adding EDTA disodium, carbomer, diglycerol and acryloyl dimethyl ammonium taurate/VP copolymer, homogenizing at high speed for 3min, heating to 80-85 deg.C, holding the temperature for 20min, and stirring to dissolve completely.
2) Adding steareth-2, steareth-21, cetearyl alcohol, isononyl isononanoate, polydimethylsiloxane and cetyl ethyl hexanoate into oil phase pot, heating to 80-85 deg.C, stirring thoroughly to dissolve, and keeping moisture for 10min.
3) Pumping all the components in the oil phase pot into an emulsifying pot, fully and uniformly mixing, homogenizing at high speed for 4 minutes, and then continuing stirring at medium speed for 5 minutes.
4) Cooling the cooling water to 60-65 ℃, adding arginine dissolved by deionized water in advance, and fully and uniformly stirring.
5) And continuously cooling to 40 ℃, adding the ethylhexyl glycerol, the phenoxyethanol and the moisturizing compositions I-V and VI-XII, fully stirring to uniformly mix, cooling to 38 ℃, inspecting, discharging qualified materials, and respectively preparing corresponding moisturizing body milks I-V and VI-XII.
TABLE 4 moisturizing body milk I-V, VI-XII formulations
| Raw material components | Body milk base formulation (%) |
| Deionized water | Is added to 100 |
| EDTA disodium salt | 0.02 |
| Carbomer | 0.08 |
| Diglycerol | 2 |
| Acryloyldimethyl ammonium taurate/VP copolymer | 0.15 |
| Steareth-2 | 1.5 |
| Steareth-21 | 0.5 |
| Cetostearyl alcohol | 0.35 |
| Isononyl isononanoate | 2 |
| Polydimethylsiloxane | 0.5 |
| Cetyl ethylhexanoate ester | 3 |
| Arginine | 0.1 |
| Ethyl hexyl glycerol | 0.15 |
| Phenoxyethanol | 0.5 |
| Moisturizing compositions I-V, VI-XII | 2 |
Test for improving skin horny layer
70 allergic dry skin volunteers were selected and tested by applying topically the moisturizing body milks I-V prepared in examples 1 to 5, the moisturizing body milks VI-XII prepared in comparative examples 1 to 7 and a blank control (body milk containing no moisturizing composition ingredient) as test samples to the skin of the left/right outer lower leg of the test subject.
Randomly grouping 70 allergic dry skin volunteers, randomly distributing 13 tested samples, and ensuring that 10 tested subjects are coated for use in each tested sample, wherein the skin on the outer side of the lower leg on one side of the random 10 tested subjects is not coatedApplying any product as control, applying to the skin of the outer side of left/right crus at a dosage of 1.5 + -0.05 g for absorption, applying to the skin of the same part of the outer side of left/right crus for 1 time respectively in the morning and evening, continuously applying for 10 days, applying diluted water-based red dye to the skin, selecting 25cm 2 And (3) attaching a skin stratum corneum cell peeling test patch, tearing off, marking, observing under an optical microscope, recording the quantity of the torn off cutin according to the table 5, and counting the number of the cutin peeled off from the test sample area and the control sample of each subject as shown in the table 6. The larger the number of persons having a small exfoliative quantity of keratinocytes, the better the skin-improving effect of the moisturizing composition.
TABLE 5 test Patch distribution status of keratinocytes in exfoliating skin stratum corneum cells
| Quantity of horny substance | Distribution condition on skin cuticle cell exfoliation test patch |
| + | It was observed that the cells appeared as small pieces after exfoliation and were sporadically distributed |
| ++ | Large flaky and small flaky cells after being peeled off can be seen and are uniformly distributed |
| +++ | It is seen that the cells are mostly in the form of large sheets and are connected into a sheet-like distribution after being peeled off |
TABLE 6 moisturizing body cream cutin improvement Effect test
As is clear from Table 6, the moisturizing body milks I to V prepared in examples 1 to 5, the moisturizing body milks VI to XII prepared in comparative examples 1 to 7 and the blank control (body milks containing no moisturizing body milk component) were compared, i.e., the Spirulina platensis extract, madecassoside, lodestone and polyhydric alcohol were synergistically effective in reducing the desquamation of the horny layer of the skin and making the skin more smooth and fine.
Compared with the example 1, the skin cuticle cell exfoliation of the comparative example 1 without the addition of the lodestone is obviously inferior to that of the example 1, namely, the effect of the moisturizing body milk VI on improving the skin exfoliation is obviously inferior to that of the moisturizing body milk I.
Compared with example 2, in comparative example 2, the effect of improving skin desquamation of moisturizing body milk VII was significantly less good than that of moisturizing body milk II due to the absence of madecassoside.
In comparative example 3, the moisturizing effect was somewhat reduced due to the decreased polyol content as compared to example 3, and the skin cuticle improving effect was not as significant as in example 3. Comparative example 4 skin keratosis was more pronounced than example 3, i.e., the effect of improving the stratum corneum of the skin was not good, because no Spirulina platensis extract was added.
Since the amount of the spirulina platensis extract was excessive, the body lotion of comparative example 5 exhibited a better skin cuticle improving effect than that of example 4, that is, the spirulina platensis extract of the present invention had an excellent moisturizing effect. However, the viscosity and the fluidity of the moisturizing body cream X fed back by the test subject are not high, and the satisfaction degree of the skin feeling evaluation of the product in the use experience is not high.
Compared with example 5, the comparative example 6 has more madecassoside, which has obvious effect of improving dandruff and smoother skin, but the more madecassoside is used, the more the cost of the cosmetic formula is increased.
Comparative example 7 compared with example 3, the used lodestone is increased, and the effect of improving skin desquamation of the moisturizing body milk XII is equivalent to that of the moisturizing body milk III; however, the subjects feed back sticky and greasy feeling of the body and have low viscosity, strong fluidity and insufficient satisfaction degree of use experience.
To sum up, the moisturizing lotion provided by the application is prepared by introducing the spirulina platensis extract, mixing the spirulina platensis extract with madecassoside, saccharide isomerous bodies and polyhydric alcohols according to a specific proportion, wherein the spirulina platensis extract contains abundant polysaccharides, and is beneficial to improving the water retention capacity of skin, the madecassoside can reduce desquamation of skin, effectively prevent excessive proliferation of keratinocytes, reduce the synthesis of matrix metalloproteinase-1, and promote the generation of collagen I, so that the skin discomfort state is improved, the saccharide isomerous bodies can promote the combination of natural moisturizing factors NMF and hyaluronic acid, so that the skin moisturizing capacity is improved, the polyhydric alcohols can prevent the moisture loss of the skin stratum corneum, and can absorb the moisture in the air, so that the skin is moisturized. The preparation method is simple and feasible, the raw materials are easy to obtain, and the preparation method is suitable for mass production. The moisturizing lotion can be added into cosmetic to improve moisturizing effect of cosmetic.
The above description is only a preferred embodiment of the present invention and is not intended to limit the present invention, and various modifications and changes may be made by those skilled in the art. Any modification, equivalent replacement, or improvement made within the spirit and principle of the present invention should be included in the protection scope of the present invention.
Claims (10)
1. A moisturizing composition is characterized by comprising, by mass, 5-15% of spirulina platensis extract, 0.5-5% of madecassoside, 10-25% of saccharide isomer and 55-80% of polyhydric alcohol.
2. The moisturizing composition of claim 1, wherein the components comprise, by mass, 6-15% of spirulina platensis extract, 0.6-5% of madecassoside, 12-25% of saccharide isomers, and 60-80% of polyhydric alcohols.
3. A moisturizing composition as in claim 1, wherein the ratio of the amount of Spirulina platensis extract, the madecassoside, the saccharide isomerate and the polyol is 1 (0.03-1): 0.67-5): 3.67-16, preferably 1 (0.1-1): 0.9-5): 4-14, more preferably 1 (0.2-1): 1-5): 5-14.
4. A moisturizing composition according to any of claims 1 to 3, characterized in that the spirulina platensis extract is prepared by a method comprising: pulverizing dried Spirulina platensis, adding 8-12 times of water, adjusting pH to 10-11, performing ultrasonic extraction at 70-80 deg.C under microwave power of 500-700W for 30-60min, centrifuging, collecting supernatant, adding 4-6 times of water, adjusting pH, performing microwave ultrasonic extraction for 20-40min, mixing the supernatants 2 times, adjusting pH to 7, adding trichloroacetic acid to remove protein, adding 4-6 times of anhydrous ethanol to precipitate, washing with acetone, and freeze drying to obtain Spirulina platensis extract.
5. A moisturizing composition according to any of claims 1-3, characterized in that the polyhydric alcohol comprises one or more of 1, 3-propanediol, butanediol, and 1, 2-pentanediol.
6. A moisturizing composition according to any of claims 1 to 3, characterized in that the saccharide isomer is lodestone.
7. A process for the preparation of a moisturizing composition according to any of claims 1 to 6 comprising mixing the components of the moisturizing composition homogeneously.
8. A cosmetic characterized by comprising the moisturizing composition as claimed in any one of claims 1 to 6.
9. Cosmetic product according to claim 8, characterized in that said moisturizing composition is added in an amount ranging from 1 to 10%, preferably from 2 to 10%, in weight percentage of the cosmetic product.
10. The cosmetic according to claim 8, wherein the cosmetic comprises at least one of a lotion, a mask, a lotion, a serum, a cream, a face cleanser, a sun block, and a sun block.
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| CN106798658A (en) * | 2017-03-08 | 2017-06-06 | 国东启 | A kind of moisture-keeping composition and skin care item |
| CN110859766A (en) * | 2019-10-14 | 2020-03-06 | 澳宝化妆品（惠州）有限公司 | Scalp multi-directional nursing composition and application thereof |
| CN111281832A (en) * | 2020-04-02 | 2020-06-16 | 广州一一生物技术有限公司 | Skin barrier repair compound, toning lotion and preparation method thereof |
| CN111407719A (en) * | 2020-04-02 | 2020-07-14 | 广州一一生物技术有限公司 | Skin barrier repair compound, face cream and preparation method thereof |
| CN113925821A (en) * | 2020-06-29 | 2022-01-14 | 广州市科能化妆品科研有限公司 | Application of spirulina H11 strain extract as antioxidant and skin care product thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106798658A (en) * | 2017-03-08 | 2017-06-06 | 国东启 | A kind of moisture-keeping composition and skin care item |
| CN110859766A (en) * | 2019-10-14 | 2020-03-06 | 澳宝化妆品（惠州）有限公司 | Scalp multi-directional nursing composition and application thereof |
| CN111281832A (en) * | 2020-04-02 | 2020-06-16 | 广州一一生物技术有限公司 | Skin barrier repair compound, toning lotion and preparation method thereof |
| CN111407719A (en) * | 2020-04-02 | 2020-07-14 | 广州一一生物技术有限公司 | Skin barrier repair compound, face cream and preparation method thereof |
| CN113925821A (en) * | 2020-06-29 | 2022-01-14 | 广州市科能化妆品科研有限公司 | Application of spirulina H11 strain extract as antioxidant and skin care product thereof |
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