CN114159348A - Skin care matrix and moisturizing skin care product suitable for cubilose acid - Google Patents
Skin care matrix and moisturizing skin care product suitable for cubilose acid Download PDFInfo
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- CN114159348A CN114159348A CN202111452981.XA CN202111452981A CN114159348A CN 114159348 A CN114159348 A CN 114159348A CN 202111452981 A CN202111452981 A CN 202111452981A CN 114159348 A CN114159348 A CN 114159348A
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- skin care
- water
- moisturizing
- acid
- care product
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- 230000003020 moisturizing effect Effects 0.000 title claims abstract description 58
- 239000002253 acid Substances 0.000 title claims abstract description 55
- 239000011159 matrix material Substances 0.000 title claims abstract description 30
- PRAKJMSDJKAYCZ-UHFFFAOYSA-N squalane Chemical compound CC(C)CCCC(C)CCCC(C)CCCCC(C)CCCC(C)CCCC(C)C PRAKJMSDJKAYCZ-UHFFFAOYSA-N 0.000 claims abstract description 46
- JXTPJDDICSTXJX-UHFFFAOYSA-N n-Triacontane Natural products CCCCCCCCCCCCCCCCCCCCCCCCCCCCCC JXTPJDDICSTXJX-UHFFFAOYSA-N 0.000 claims abstract description 23
- 229940032094 squalane Drugs 0.000 claims abstract description 23
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 22
- 239000004359 castor oil Substances 0.000 claims abstract description 20
- 235000019438 castor oil Nutrition 0.000 claims abstract description 20
- ZEMPKEQAKRGZGQ-XOQCFJPHSA-N glycerol triricinoleate Natural products CCCCCC[C@@H](O)CC=CCCCCCCCC(=O)OC[C@@H](COC(=O)CCCCCCCC=CC[C@@H](O)CCCCCC)OC(=O)CCCCCCCC=CC[C@H](O)CCCCCC ZEMPKEQAKRGZGQ-XOQCFJPHSA-N 0.000 claims abstract description 20
- 229920002545 silicone oil Polymers 0.000 claims abstract description 20
- 125000005456 glyceride group Chemical group 0.000 claims abstract description 17
- WWZKQHOCKIZLMA-UHFFFAOYSA-N octanoic acid Chemical compound CCCCCCCC(O)=O WWZKQHOCKIZLMA-UHFFFAOYSA-N 0.000 claims abstract description 14
- 239000003995 emulsifying agent Substances 0.000 claims abstract description 7
- 239000003906 humectant Substances 0.000 claims abstract description 7
- 239000002562 thickening agent Substances 0.000 claims abstract description 7
- PEDCQBHIVMGVHV-UHFFFAOYSA-N glycerol group Chemical group OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 28
- MRIXVKKOHPQOFK-UHFFFAOYSA-N 4-methoxysalicylic acid Chemical compound COC1=CC=C(C(O)=O)C(O)=C1 MRIXVKKOHPQOFK-UHFFFAOYSA-N 0.000 claims description 16
- 239000004475 Arginine Substances 0.000 claims description 13
- ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 claims description 13
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- 235000010493 xanthan gum Nutrition 0.000 claims description 13
- LXAHHHIGZXPRKQ-UHFFFAOYSA-N 5-fluoro-2-methylpyridine Chemical compound CC1=CC=C(F)C=N1 LXAHHHIGZXPRKQ-UHFFFAOYSA-N 0.000 claims description 10
- 235000011187 glycerol Nutrition 0.000 claims description 10
- ANZUDYZHSVGBRF-UHFFFAOYSA-N 3-ethylnonane-1,2,3-triol Chemical compound CCCCCCC(O)(CC)C(O)CO ANZUDYZHSVGBRF-UHFFFAOYSA-N 0.000 claims description 8
- IZZIWIAOVZOBLF-UHFFFAOYSA-N 5-methyloxysalicylic acid Natural products COC1=CC=C(O)C(C(O)=O)=C1 IZZIWIAOVZOBLF-UHFFFAOYSA-N 0.000 claims description 8
- QCDWFXQBSFUVSP-UHFFFAOYSA-N 2-phenoxyethanol Chemical compound OCCOC1=CC=CC=C1 QCDWFXQBSFUVSP-UHFFFAOYSA-N 0.000 claims description 7
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 7
- 238000002156 mixing Methods 0.000 claims description 7
- 229960005323 phenoxyethanol Drugs 0.000 claims description 7
- 238000001816 cooling Methods 0.000 claims description 3
- NCZPCONIKBICGS-UHFFFAOYSA-N 3-(2-ethylhexoxy)propane-1,2-diol Chemical compound CCCCC(CC)COCC(O)CO NCZPCONIKBICGS-UHFFFAOYSA-N 0.000 claims description 2
- 244000000626 Daucus carota Species 0.000 claims description 2
- 239000000043 antiallergic agent Substances 0.000 claims description 2
- 235000005770 birds nest Nutrition 0.000 claims description 2
- 239000002738 chelating agent Substances 0.000 claims description 2
- GHVNFZFCNZKVNT-UHFFFAOYSA-M decanoate Chemical compound CCCCCCCCCC([O-])=O GHVNFZFCNZKVNT-UHFFFAOYSA-M 0.000 claims description 2
- 229940100524 ethylhexylglycerin Drugs 0.000 claims description 2
- 229940080812 glyceryl caprate Drugs 0.000 claims description 2
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- 239000000049 pigment Substances 0.000 claims description 2
- 239000003755 preservative agent Substances 0.000 claims description 2
- 230000002335 preservative effect Effects 0.000 claims description 2
- GHBFNMLVSPCDGN-UHFFFAOYSA-N rac-1-monooctanoylglycerol Chemical compound CCCCCCCC(=O)OCC(O)CO GHBFNMLVSPCDGN-UHFFFAOYSA-N 0.000 claims description 2
- 235000005765 wild carrot Nutrition 0.000 claims description 2
- 238000004519 manufacturing process Methods 0.000 claims 1
- 230000002195 synergetic effect Effects 0.000 abstract description 4
- 239000000203 mixture Substances 0.000 abstract description 2
- 238000012360 testing method Methods 0.000 description 18
- SQVRNKJHWKZAKO-UHFFFAOYSA-N beta-N-Acetyl-D-neuraminic acid Natural products CC(=O)NC1C(O)CC(O)(C(O)=O)OC1C(O)C(O)CO SQVRNKJHWKZAKO-UHFFFAOYSA-N 0.000 description 8
- 230000000052 comparative effect Effects 0.000 description 8
- 238000003756 stirring Methods 0.000 description 7
- PUPZLCDOIYMWBV-UHFFFAOYSA-N (+/-)-1,3-Butanediol Chemical compound CC(O)CCO PUPZLCDOIYMWBV-UHFFFAOYSA-N 0.000 description 6
- TXFPEBPIARQUIG-UHFFFAOYSA-N 4'-hydroxyacetophenone Chemical compound CC(=O)C1=CC=C(O)C=C1 TXFPEBPIARQUIG-UHFFFAOYSA-N 0.000 description 6
- POJWUDADGALRAB-UHFFFAOYSA-N allantoin Chemical compound NC(=O)NC1NC(=O)NC1=O POJWUDADGALRAB-UHFFFAOYSA-N 0.000 description 6
- SQVRNKJHWKZAKO-PFQGKNLYSA-N N-acetyl-beta-neuraminic acid Chemical compound CC(=O)N[C@@H]1[C@@H](O)C[C@@](O)(C(O)=O)O[C@H]1[C@H](O)[C@H](O)CO SQVRNKJHWKZAKO-PFQGKNLYSA-N 0.000 description 5
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- POJWUDADGALRAB-PVQJCKRUSA-N Allantoin Natural products NC(=O)N[C@@H]1NC(=O)NC1=O POJWUDADGALRAB-PVQJCKRUSA-N 0.000 description 3
- 229960000458 allantoin Drugs 0.000 description 3
- 235000019437 butane-1,3-diol Nutrition 0.000 description 3
- 239000008367 deionised water Substances 0.000 description 3
- 229910021641 deionized water Inorganic materials 0.000 description 3
- BNIILDVGGAEEIG-UHFFFAOYSA-L disodium hydrogen phosphate Chemical compound [Na+].[Na+].OP([O-])([O-])=O BNIILDVGGAEEIG-UHFFFAOYSA-L 0.000 description 3
- 238000001035 drying Methods 0.000 description 3
- 229910000403 monosodium phosphate Inorganic materials 0.000 description 3
- 235000019799 monosodium phosphate Nutrition 0.000 description 3
- 238000011160 research Methods 0.000 description 3
- SQVRNKJHWKZAKO-OQPLDHBCSA-N sialic acid Chemical compound CC(=O)N[C@@H]1[C@@H](O)C[C@@](O)(C(O)=O)OC1[C@H](O)[C@H](O)CO SQVRNKJHWKZAKO-OQPLDHBCSA-N 0.000 description 3
- AJPJDKMHJJGVTQ-UHFFFAOYSA-M sodium dihydrogen phosphate Chemical compound [Na+].OP(O)([O-])=O AJPJDKMHJJGVTQ-UHFFFAOYSA-M 0.000 description 3
- 238000005303 weighing Methods 0.000 description 3
- CERZMXAJYMMUDR-QBTAGHCHSA-N 5-amino-3,5-dideoxy-D-glycero-D-galacto-non-2-ulopyranosonic acid Chemical class N[C@@H]1[C@@H](O)CC(O)(C(O)=O)O[C@H]1[C@H](O)[C@H](O)CO CERZMXAJYMMUDR-QBTAGHCHSA-N 0.000 description 2
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical group N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 2
- 230000008901 benefit Effects 0.000 description 2
- 238000007599 discharging Methods 0.000 description 2
- 239000006185 dispersion Substances 0.000 description 2
- 238000010438 heat treatment Methods 0.000 description 2
- 238000000338 in vitro Methods 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- 239000000178 monomer Substances 0.000 description 2
- 239000003921 oil Substances 0.000 description 2
- HVCOBJNICQPDBP-UHFFFAOYSA-N 3-[3-[3,5-dihydroxy-6-methyl-4-(3,4,5-trihydroxy-6-methyloxan-2-yl)oxyoxan-2-yl]oxydecanoyloxy]decanoic acid;hydrate Chemical compound O.OC1C(OC(CC(=O)OC(CCCCCCC)CC(O)=O)CCCCCCC)OC(C)C(O)C1OC1C(O)C(O)C(O)C(C)O1 HVCOBJNICQPDBP-UHFFFAOYSA-N 0.000 description 1
- 206010067484 Adverse reaction Diseases 0.000 description 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 1
- 229930186217 Glycolipid Natural products 0.000 description 1
- 102000003886 Glycoproteins Human genes 0.000 description 1
- 108090000288 Glycoproteins Proteins 0.000 description 1
- 206010061218 Inflammation Diseases 0.000 description 1
- 206010040914 Skin reaction Diseases 0.000 description 1
- 241000700605 Viruses Species 0.000 description 1
- 230000002411 adverse Effects 0.000 description 1
- 230000006838 adverse reaction Effects 0.000 description 1
- 125000000637 arginyl group Chemical group N[C@@H](CCCNC(N)=N)C(=O)* 0.000 description 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical group [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 1
- 239000012752 auxiliary agent Substances 0.000 description 1
- 229910052799 carbon Inorganic materials 0.000 description 1
- 230000005859 cell recognition Effects 0.000 description 1
- 239000003153 chemical reaction reagent Substances 0.000 description 1
- 230000019771 cognition Effects 0.000 description 1
- 230000002596 correlated effect Effects 0.000 description 1
- 230000000875 corresponding effect Effects 0.000 description 1
- 239000002537 cosmetic Substances 0.000 description 1
- 238000013400 design of experiment Methods 0.000 description 1
- 230000001804 emulsifying effect Effects 0.000 description 1
- 239000000839 emulsion Substances 0.000 description 1
- 239000000686 essence Substances 0.000 description 1
- 238000011156 evaluation Methods 0.000 description 1
- 238000013401 experimental design Methods 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 230000001815 facial effect Effects 0.000 description 1
- 210000000245 forearm Anatomy 0.000 description 1
- 230000006870 function Effects 0.000 description 1
- 230000004054 inflammatory process Effects 0.000 description 1
- 239000004816 latex Substances 0.000 description 1
- 229920000126 latex Polymers 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 239000011259 mixed solution Substances 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 239000003607 modifier Substances 0.000 description 1
- 230000030363 nerve development Effects 0.000 description 1
- CERZMXAJYMMUDR-UHFFFAOYSA-N neuraminic acid Natural products NC1C(O)CC(O)(C(O)=O)OC1C(O)C(O)CO CERZMXAJYMMUDR-UHFFFAOYSA-N 0.000 description 1
- 229910052757 nitrogen Inorganic materials 0.000 description 1
- 229920001542 oligosaccharide Polymers 0.000 description 1
- 150000002482 oligosaccharides Chemical class 0.000 description 1
- 239000001301 oxygen Chemical group 0.000 description 1
- 229910052760 oxygen Chemical group 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 230000001737 promoting effect Effects 0.000 description 1
- 239000002994 raw material Substances 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 238000012827 research and development Methods 0.000 description 1
- 210000002966 serum Anatomy 0.000 description 1
- 238000010008 shearing Methods 0.000 description 1
- 231100000430 skin reaction Toxicity 0.000 description 1
- 230000035483 skin reaction Effects 0.000 description 1
- 238000007619 statistical method Methods 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- 230000001502 supplementing effect Effects 0.000 description 1
- 230000004083 survival effect Effects 0.000 description 1
- 238000012353 t test Methods 0.000 description 1
- 238000010998 test method Methods 0.000 description 1
- 230000002087 whitening effect Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
- A61K8/922—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/31—Hydrocarbons
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/37—Esters of carboxylic acids
- A61K8/375—Esters of carboxylic acids the alcohol moiety containing more than one hydroxy group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/60—Sugars; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/84—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
- A61K8/89—Polysiloxanes
- A61K8/891—Polysiloxanes saturated, e.g. dimethicone, phenyl trimethicone, C24-C28 methicone or stearyl dimethicone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Emergency Medicine (AREA)
- Dermatology (AREA)
- Chemical & Material Sciences (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Cosmetics (AREA)
Abstract
The invention provides a skin-care matrix and a moisturizing skin-care product suitable for cubilose acid, wherein the skin-care matrix comprises water-soluble silicone oil, squalane, caprylic-capric glyceride, hydrogenated castor oil, a humectant, an emulsifier, a thickener and water; the skin care base comprises a skin care base body, a water-soluble silicone oil, squalane, caprylic/capric glyceride and hydrogenated castor oil, wherein the mass percentage sum of the water-soluble silicone oil, squalane, caprylic/capric glyceride and hydrogenated castor oil in the skin care base body is 3.5-4.2%, and the mass percentage of water in the skin care base body is 88-92%. According to the invention, the skin-care matrix with a specific composition is compounded with the cubilose acid, so that a synergistic moisturizing effect can be generated, and the moisturizing effect of the skin-care product with the cubilose acid added with a higher concentration can still be achieved under the condition that the cubilose acid concentration is lower (0.1-1%) and the overall concentration of the matrix is lower.
Description
Technical Field
The invention relates to the technical field of skin care products, in particular to a skin care matrix and a moisturizing skin care product suitable for cubilose acid.
Background
Cubilose acid (SA), also called Sialic acid, N-acetylneuraminic acid, is a group of nitrogen or oxygen substituted derivatives of neuraminic acid, which are all negatively charged nine-carbon sugar neuraminic acid. Cubilose acid is widely present in mammalian tissues, is an important component of glycoprotein, oligosaccharide and glycolipid, and participates in cell recognition, survival, multiplication and the like. The research shows that the cubilose acid has the functions of promoting nerve development, resisting virus, resisting inflammation, whitening skin, moisturizing and the like.
In view of the multiple effects of the cubilose acid, more and more skin care products are added with the cubilose acid on the market at present, but based on the existing cognition of people, the higher the addition amount of the cubilose acid is, the better the effect is. For example, CN111743810A discloses a moisturizing skin care product containing N-acetylneuraminic acid, wherein the N-acetylneuraminic acid is added in an amount of 5% or more in order to provide the product with a good moisturizing effect. Further, in the conventional studies conducted by the inventors, the higher the concentration of the bird's nest acid, the better the moisture retention. For example, in CN104083291A, when the content of the sialic acid monomer is 0.5-2.0% by mass, the moisture retention rate of the sialic acid monomer is positively correlated with the concentration thereof in the moisture retention rate measurement of 4 hours in a short time and 24 hours and 48 hours in a long time.
Disclosure of Invention
The invention provides a skin-care matrix and a moisturizing skin-care product suitable for cubilose acid.
The invention adopts the following technical scheme:
the invention provides a skin-care matrix suitable for cubilose acid, which comprises water-soluble silicone oil, squalane, caprylic-capric glyceride, hydrogenated castor oil, a humectant, an emulsifier, a thickener and water;
the skin care base comprises a skin care base body, a water-soluble silicone oil, squalane, caprylic/capric glyceride and hydrogenated castor oil, wherein the mass percentage sum of the water-soluble silicone oil, squalane, caprylic/capric glyceride and hydrogenated castor oil in the skin care base body is 3.5-4.2%, and the mass percentage of water in the skin care base body is 88-92%.
Based on previous research of the inventor and relevant content of the prior art disclosure, the inventor also considers that the higher the addition amount of the cubilose acid in the moisture-preserving skin-care product is, the better the cubilose acid is, after a certain effect is achieved, economic benefits are comprehensively considered, the cubilose acid content is not increased once, and the good moisture-preserving effect and the low cost are both achieved. However, the inventor obtains the specific skin care matrix in the research and development process, and the specific skin care matrix is matched with the cubilose acid, so that the synergistic effect can be realized, the dosage of the cubilose acid can be reduced, and the moisture-keeping effect of the skin care product with the cubilose acid added in higher concentration can still be achieved under the condition that the cubilose acid concentration is lower and the overall concentration of the matrix is lower. The inventor conjectures that the compatibility of the water-soluble silicone oil, squalane, caprylic/capric glyceride and hydrogenated castor oil which are high in oil phase components in the skin-care matrix realizes the key of better moisturizing effect by using less moisturizing components.
Further, the skin care matrix comprises the following components in percentage by weight: 1.5-1.8% of water-soluble silicone oil, 0.8-1% of squalane, 0.8-1% of caprylic/capric glyceride, 0.2-0.4% of hydrogenated castor oil, 2-3% of a humectant, 0.5-0.8% of an emulsifier, 0.4-0.7% of a thickener and 88-92% of water.
Further, in the above technical scheme, the humectant is glycerin, ethylhexyl glycerin; the emulsifier is PEG/PPG-17/6 copolymer; the thickening agent is xanthan gum.
Further, the skin care matrix also comprises one or more of skin feel regulator, antiallergic agent, preservative, chelating agent, essence, pigment and other auxiliary agents, and the total addition amount of the skin care matrix is not more than 1 percent of the skin care matrix; wherein the skin feel modifier is arginine.
Based on the skin care matrix suitable for the cubilose acid, the invention also provides a moisturizing skin care product which is composed of the cubilose acid and the skin care matrix.
Further, the mass fraction of the cubilose acid in the moisturizing skin care product is 0.1-1%. Due to the synergistic effect of the skin care matrix and the cubilose acid, the cubilose acid can be added in an amount of 0.1-1%, and the moisturizing effect equivalent to that of a skin care product with higher cubilose acid addition in the prior art can be realized.
In a preferred embodiment of the invention, the moisturizing skin care product consists of the following components in percentage by weight: 0.1-1% of cubilose acid, 1.5-1.6% of water-soluble silicone oil, 0.8-1% of synthetic squalane, 0.6-0.7% of PEG/PPG-17/6 copolymer, 0.8-0.9% of glyceryl caprylate/caprate, 1-1.2% of glycerol, 1-1.2% of ethylhexyl glycerol, 0.2-0.3% of 4-methoxysalicylic acid, 0.1-0.3% of xanthan gum, 0.1-1% of arginine, 0.2-0.3% of hydrogenated castor oil, 0.01-0.1% of EDTA-disodium, 0.1-0.5% of phenoxyethanol, 0.01-0.06% of cellulose powder and the balance of water.
Further preferably, the invention can achieve better moisturizing effect at smaller applied concentrations of the cubilose acid, wherein the content of the cubilose acid can be as low as 0.1-0.2%.
In a specific application example, the oil phase and the moisturizing component in the moisturizing skin care product can be as follows by weight percentage: 0.1% of cubilose acid, 1.6% of water-soluble silicone oil, 1% of synthetic squalane, 0.6% of PEG/PPG-17/6 copolymer, 0.9% of caprylic/capric glyceride, 1.1% of glycerol, 1.2% of ethylhexyl glycerol, 0.3% of 4-methoxysalicylic acid, 0.2% of xanthan gum, 0.5% of arginine and 0.3% of hydrogenated castor oil.
The invention also provides a preparation method of the moisturizing skin care product, which comprises the following steps: uniformly mixing the components except for the cubilose acid and the arginine at 75-80 ℃, cooling to 40-45 ℃, adding the cubilose acid and the arginine, and uniformly mixing again.
The invention also provides application of the moisturizing skin care product in human skin care, and specifically, the moisturizing skin care product can be directly used, coated on a required part of a human body, or further processed into other forms of skin care products for use. Preferably, the moisturizing skin care product of the present invention is suitable for use as a product in the form of an emulsion, a serum, or the like. When the moisturizing skin care product is directly coated for use, the dosage of the moisturizing skin care product is 2.0 +/-0.1 mg/cm2。
The invention provides a skin-care matrix and a moisturizing skin-care product suitable for cubilose acid, and the skin-care matrix and the cubilose acid with specific compositions are compounded to generate a synergistic moisturizing effect, so that the moisturizing effect equivalent to that of the skin-care product with higher addition of the cubilose acid in the prior art is still achieved under the conditions that the concentration of the cubilose acid is lower (0.1-1%) and the overall concentration of the matrix is lower.
Detailed Description
In order to make the objects, technical solutions and advantages of the embodiments of the present invention clearer, the technical solutions in the embodiments of the present invention are clearly and completely described below, and it is obvious that the described embodiments are a part of the embodiments of the present invention, but not all of the embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
The raw materials and auxiliary materials used in the following examples are all commercially available unless otherwise specified.
Example 1
This example provides a skin care base suitable for cubilose acid, which comprises the following components:
0.5g of arginine, 1.6g of water-soluble silicone oil, 1g of synthetic squalane, 0.6g of PEG/PPG-17/6 copolymer, 0.9g of caprylic/capric glyceride, 1.1g of glycerol, 1.2g of ethylhexyl glycerol, 0.3g of 4-methoxysalicylic acid, 0.2g of xanthan gum, 0.3g of hydrogenated castor oil, 0.05g of EDTA-disodium, 0.5g of phenoxyethanol and 0.04g of cellulose powder, and the balance of water is added to make up to 100 g.
Example 2
The embodiment provides a moisturizing skin care product, which comprises the following components:
0.1g of cubilose acid, 0.5g of arginine, 1.6g of water-soluble silicone oil, 1g of synthetic squalane, 0.6g of PEG/PPG-17/6 copolymer, 0.9g of caprylic/capric glyceride, 1.1g of glycerol, 1.2g of ethylhexyl glycerol, 0.3g of 4-methoxysalicylic acid, 0.2g of xanthan gum, 0.3g of hydrogenated castor oil, 0.05g of EDTA-disodium, 0.5g of phenoxyethanol, 0.04g of cellulose powder, and the balance of water to be up to 100 g.
The embodiment also provides a preparation method of the moisturizing skin care product, which comprises the following specific steps:
heating weighed water-soluble silicone oil, synthetic squalane, PEG/PPG-17/6 copolymer, caprylic capric acid glyceride, glycerol, ethylhexyl glycerol, 4-methoxysalicylic acid, xanthan gum, hydrogenated castor oil, EDTA-disodium, phenoxyethanol, cellulose powder and water in a constant-temperature water bath at 78 ℃, stirring and mixing uniformly after high-speed shearing, then cooling to 40 ℃, adding cubilose acid and arginine, stirring and mixing uniformly again, and discharging.
Example 3
The embodiment provides a moisturizing skin care product, which comprises the following components:
0.5g of cubilose acid, 0.5g of arginine, 1.6g of water-soluble silicone oil, 1g of synthetic squalane, 0.6g of PEG/PPG-17/6 copolymer, 0.9g of caprylic/capric glyceride, 1.1g of glycerol, 1.2g of ethylhexyl glycerol, 0.3g of 4-methoxysalicylic acid, 0.2g of xanthan gum, 0.3g of hydrogenated castor oil, 0.05g of EDTA-disodium, 0.5g of phenoxyethanol, 0.04g of cellulose powder, and the balance of water to be up to 100 g. The preparation method is the same as that of example 2.
Example 4
The embodiment provides a moisturizing skin care product, which comprises the following components:
1.0g of cubilose acid, 0.5g of arginine, 1.6g of water-soluble silicone oil, 1g of synthetic squalane, 0.6g of PEG/PPG-17/6 copolymer, 0.9g of caprylic/capric glyceride, 1.1g of glycerol, 1.2g of ethylhexyl glycerol, 0.3g of 4-methoxysalicylic acid, 0.2g of xanthan gum, 0.3g of hydrogenated castor oil, 0.05g of EDTA-disodium, 0.5g of phenoxyethanol, 0.04g of cellulose powder, and the balance of water to be up to 100 g. The preparation method is the same as that of example 2.
Comparative example 1
The comparative example provides a moisturizing skin care product, which comprises the following specific components:
taking 5g of N-acetylneuraminic acid, 6.6g of 1, 3-butanediol, 0.4g of p-hydroxyacetophenone, 0.6g of PEG/PPG-17/6 copolymer, 0.15g of synthetic squalane, 0.15g of allantoin, 0.04g of EDTA-disodium, 0.3g of xanthan gum, adjusting the pH value to 6.8 by using disodium hydrogen phosphate and sodium dihydrogen phosphate, and 85g of deionized water.
Heating the weighed 1, 3-butanediol, synthetic squalane, allantoin, PEG/PPG-17/6 copolymer, EDTA-disodium and deionized water in a constant-temperature water bath at 75 ℃, stirring and mixing for 1h by using a high-speed dispersion homogenizer, emulsifying uniformly, adding p-hydroxyacetophenone and xanthan gum, continuously stirring for 30min at 75 ℃ by using a high-speed dispersion homogenizer, and standing for 12h after stirring. And then placing the mixed solution in a constant-temperature water bath at 40 ℃, adding the weighed N-acetylneuraminic acid, stirring for 30min, adding disodium hydrogen phosphate and sodium dihydrogen phosphate after stirring is finished, adjusting the pH value to 6.8, and discharging.
Comparative example 2
The comparative example provides a moisturizing skin care product, which specifically comprises the following components:
2g of cubilose acid, 6.6g of 1, 3-butanediol, 0.4g of p-hydroxyacetophenone, 0.6g of PEG/PPG-17/6 copolymer, 0.15g of synthetic squalane and 0.15g of allantoin, 0.04g of EDTA-disodium, 0.3g of xanthan gum, adjusting the pH to 6.8 by using disodium hydrogen phosphate and sodium dihydrogen phosphate, and supplementing the rest of deionized water to 100 g. The preparation method is the same as that of comparative example 1.
Test example 1 in vitro test
The skin care base/moisturizing skin care product provided in each example and comparative example was tested for in vitro moisturizing effect.
The sample containing certain moisture is placed in a dryer for drying through a weighing method, the mass of the sample is weighed after a certain time, and the moisturizing effect of the moisturizing skin care product is analyzed through the reduction of the moisture.
1. And (3) respectively taking 0.5g of each sample to be tested, putting the sample into a glass dish, wherein the specification of the glass dish is that the diameter of an upper cover is 95mm, the diameter of a lower bottom is 90m, the height of the dish is 15m, placing the open part of the glass dish into a drying box with the relative humidity of 60%, weighing and recording every 40min, and calculating the moisture retention rate. The test results are shown in the following table.
TABLE moisturizing Effect of samples at 160% relative humidity
2. And (3) respectively taking 0.5g of each sample to be tested, putting the sample into a glass vessel with the same specification, placing the open end of the glass vessel into a drying box with the relative humidity of 30%, weighing and recording every 40min, and calculating the moisture retention rate. The test results are shown in the following table.
TABLE moisturizing Effect of samples at 230% relative humidity
From the above results, it is understood that the moisturizing skin care products provided by the examples of the present invention all had good moisturizing rates in the environment with relative humidity of 30% and 60%, which is equivalent to that of comparative example 1.
Test example 2 clinical test
1. Test information
(1) Test samples: the skin care base of example 1, the moisturizing skin care products of examples 2-4 and comparative example 2;
(2) the test purpose is as follows: the moisturizing efficacy of the product within 8 hours of use was evaluated by a skin moisture content test;
(3) the test method comprises the following steps: evaluation guideline for moisturizing efficacy of cosmetic product QB/T4256 plus 2011;
(4) testing an instrument: corneometer (CM825, Courage + khazaka)
Electronic balance (ME104E/02, Mettler Toledo)
Pipette gun (10-100. mu.l, Eppendorf Research);
(5) reagents and materials: dry facial tissue, latex finger stall, alcohol, dust-free paper, pipette tip;
(6) subject information: female, 25 (original 26 eligible subjects were tested, 1 subject was withdrawn for personal reasons during the test), age 23-56 years;
(7) test area: the inner side of the forearm;
(8) testing time points: initial values, 2 hours, 4 hours, 8 hours after product use.
2. Design of experiments
Based on random, double blind experimental design. 26 qualified female volunteers were tested, and 5 test products and blank control were randomly distributed in 6 regions to be tested (3.0 × 4.0 cm) on the inner side of the left and right front arms of the volunteers2). The product is used by the technical personnel for the subject in a single time on site, and the dosage of the product is (2.0 +/-0.1) mg/cm2. Each test area was tested for skin moisture content (Corneometer) before use of the product, 2 hours, 4 hours, 8 hours after a single use of the product.
3. Adverse reaction recording
During the test, no adverse skin reactions were observed in the subjects.
4. Test results
TABLE 3 moisturizing Effect of the samples in clinical experiments
Note: the statistical method comprises the following steps: dunnett-t test, which shows that the water content of the same sample at each time point has significant difference compared with the initial value, and P is less than or equal to 0.05; indicates that the difference value of a certain sample compared with the blank has a significant difference from the initial value, and P is less than or equal to 0.05.
From the results, the moisturizing skin care product disclosed by the invention shows good moisturizing effect within 8 hours of single use of a human body.
Finally, it should be noted that: the above examples are only intended to illustrate the technical solution of the present invention, but not to limit it; although the present invention has been described in detail with reference to the foregoing embodiments, it will be understood by those of ordinary skill in the art that: the technical solutions described in the foregoing embodiments may still be modified, or some technical features may be equivalently replaced; and such modifications or substitutions do not depart from the spirit and scope of the corresponding technical solutions of the embodiments of the present invention.
Claims (10)
1. A skin care matrix suitable for cubilose acid is characterized by comprising water-soluble silicone oil, squalane, caprylic-capric glyceride, hydrogenated castor oil, a humectant, an emulsifier, a thickener and water;
the skin care base comprises a skin care base body, a water-soluble silicone oil, squalane, caprylic/capric glyceride and hydrogenated castor oil, wherein the mass percentage sum of the water-soluble silicone oil, squalane, caprylic/capric glyceride and hydrogenated castor oil in the skin care base body is 3.5-4.2%, and the mass percentage of water in the skin care base body is 88-92%.
2. The skin care matrix suitable for cubilose acid according to claim 1, characterized in that the skin care matrix comprises the following components in percentage by weight: 1.5-1.8% of water-soluble silicone oil, 0.8-1% of squalane, 0.8-1% of caprylic/capric glyceride, 0.2-0.4% of hydrogenated castor oil, 2-3% of a humectant, 0.5-0.8% of an emulsifier, 0.4-0.7% of a thickener and 88-92% of water.
3. The skin care base suitable for bird's nest acid of claim 2, characterized by, that the humectant is glycerin, ethyl hexyl glycerin;
the emulsifier is PEG/PPG-17/6 copolymer;
the thickening agent is xanthan gum.
4. The skin care matrix suitable for the cubilose acid as claimed in any one of claims 1 to 3, wherein the skin care matrix further comprises one or more of a skin feel regulator, an anti-allergy agent, a preservative, a chelating agent, an essence and a pigment, and the total addition amount of the skin care matrix is not more than 1% of the skin care matrix.
5. A moisturizing skin care product characterized by consisting of cubilose acid and the skin care base according to any one of claims 1 to 4.
6. The moisturizing skin care product according to claim 5, wherein the mass fraction of the cubilose acid in the moisturizing skin care product is 0.1-1%.
7. The moisturizing skin care product of claim 5, wherein the moisturizing skin care product consists of the following components in percentage by weight: 0.1-1% of cubilose acid, 1.5-1.6% of water-soluble silicone oil, 0.8-1% of synthetic squalane, 0.6-0.7% of PEG/PPG-17/6 copolymer, 0.8-0.9% of glyceryl caprylate/caprate, 1-1.2% of glycerol, 1-1.2% of ethylhexyl glycerol, 0.2-0.3% of 4-methoxysalicylic acid, 0.1-0.3% of xanthan gum, 0.1-1% of arginine, 0.2-0.3% of hydrogenated castor oil, 0.01-0.1% of EDTA-disodium, 0.1-0.5% of phenoxyethanol, 0.01-0.06% of cellulose powder and the balance of water.
8. The moisturizing skin care product of claim 7, wherein the content of the cubilose acid in the moisturizing skin care product is 0.1-0.2% by weight.
9. The method for producing a moisturizing skin care product according to claim 7 or 8, comprising: uniformly mixing the components except for the cubilose acid and the arginine at 75-80 ℃, cooling to 40-45 ℃, adding the cubilose acid and the arginine, and uniformly mixing again.
10. Use of the moisturizing skin care product of any one of claims 5 to 8 in skin care of a human body, wherein the amount of the moisturizing skin care product is 2.0 ± 0.1mg/cm2。
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| CN114939076A (en) * | 2022-05-12 | 2022-08-26 | 武汉中科光谷绿色生物技术有限公司 | Sialic acid solid composition and preparation method and application thereof |
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