CN115811981A - 包含胎儿附属物来源组织细胞培养上清的脑神经损伤治疗剂 - Google Patents

包含胎儿附属物来源组织细胞培养上清的脑神经损伤治疗剂 Download PDF

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CN115811981A
CN115811981A CN202180047221.2A CN202180047221A CN115811981A CN 115811981 A CN115811981 A CN 115811981A CN 202180047221 A CN202180047221 A CN 202180047221A CN 115811981 A CN115811981 A CN 115811981A
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cranial nerve
cells
agent
derived
culture supernatant
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相良祐辅
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Kochi University NUC
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Kochi University NUC
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CN202180047221.2A 2020-06-30 2021-06-30 包含胎儿附属物来源组织细胞培养上清的脑神经损伤治疗剂 Pending CN115811981A (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
JP2020113456 2020-06-30
JP2020-113456 2020-06-30
JP2020-149878 2020-09-07
JP2020149878A JP6967308B1 (ja) 2020-06-30 2020-09-07 胎児付属物由来組織細胞培養上清を含む脳神経障害治療剤
PCT/JP2021/024837 WO2022004816A1 (ja) 2020-06-30 2021-06-30 胎児付属物由来組織細胞培養上清を含む脳神経障害治療剤

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Publication Number Publication Date
CN115811981A true CN115811981A (zh) 2023-03-17

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CN202180047221.2A Pending CN115811981A (zh) 2020-06-30 2021-06-30 包含胎儿附属物来源组织细胞培养上清的脑神经损伤治疗剂

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US (1) US20230242870A1 (https=)
EP (1) EP4173629A4 (https=)
JP (2) JP6967308B1 (https=)
CN (1) CN115811981A (https=)
WO (1) WO2022004816A1 (https=)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
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JP6967308B1 (ja) * 2020-06-30 2021-11-17 国立大学法人高知大学 胎児付属物由来組織細胞培養上清を含む脳神経障害治療剤
CN117679520A (zh) * 2022-09-09 2024-03-12 北京达尔文细胞生物科技有限公司 用于防治后遗症期面神经麻痹的药物组合物及其应用
WO2025100424A1 (ja) * 2023-11-10 2025-05-15 国立大学法人 東京大学 急性脳症治療剤及び急性脳症の治療方法
WO2025182103A1 (ja) * 2024-02-28 2025-09-04 セルソース株式会社 脳梗塞の機能予後改善用組成物

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002098361A2 (en) * 2001-06-01 2002-12-12 Xcyte Therapies, Inc. T cell induced tissue repair and regeneration

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5190556A (en) 1991-03-19 1993-03-02 O.B. Tech, Inc. Cord cutter sampler
US5372581A (en) 1993-07-21 1994-12-13 Minneapolis Children's Services Corporation Method and apparatus for placental blood collection
WO2005001080A2 (en) * 2003-06-27 2005-01-06 Ethicon, Incorporated Postpartum-derived cells for use in treatment of disease of the heart and circulatory system
WO2006071778A2 (en) * 2004-12-23 2006-07-06 Ethicon Incorporated Treatment of parkinson's disease and related disorders using postpartum derived cells
EP2139497B1 (en) * 2007-04-13 2013-11-06 Stemnion, INC. Methods for treating nervous system injury and disease
JP6095893B2 (ja) * 2008-12-19 2017-03-15 デピュイ・シンセス・プロダクツ・インコーポレイテッド 傷害後の神経組織の再生および修復
SG174551A1 (en) * 2009-03-26 2011-10-28 Ethicon Inc Human umbilical cord tissue cells as therapy for alzheimer' s disease
MX2013006592A (es) * 2010-12-17 2014-02-06 Anthrogenesis Corp Tratamiento de lesion de la medula espinal y lesion traumatica de cerebro empleando celulas adherentes obtenidas del amnios.
US20120276215A1 (en) * 2011-04-26 2012-11-01 Riordan Neil H Therapeutic Conditioned Media
CN104321426A (zh) * 2012-03-28 2015-01-28 石匠株式会社 永生化干细胞以及以其生成物为有效成分的药物组合物和药物制剂
US10167448B2 (en) * 2013-12-12 2019-01-01 Samsung Life Public Welfare Foundation Pharmaceutical composition for treating cerebrovascular diseases, containing stem cell-derived exosome as active ingredient
DK3145493T3 (da) * 2014-05-18 2022-10-31 Childrens Medical Center Fremgangsmåder og sammensætninger vedrørende exosomer
EP3307286B1 (en) * 2015-06-12 2023-01-11 Hudson Institute of Medical Research Allogeneic mammalian amniotic exosomes for treating a fibrotic disease
WO2017204231A1 (ja) * 2016-05-24 2017-11-30 国立大学法人 東京大学 臍帯由来細胞を含む脳障害の治療剤
KR20190109389A (ko) * 2016-11-03 2019-09-25 엑소스템 바이오텍 리미티드 간엽 줄기 세포 집단, 이들의 산물 및 이들의 용도
CA3064064A1 (en) * 2017-05-16 2018-11-22 Exostem Biotec Ltd. Methods of inhibiting aging and treating aging-related disorders
CA3069805A1 (en) * 2017-07-14 2019-01-17 Orbsen Therapeutics Limited Cd39 stromal stem cells methods of isolation and use
JP2020093988A (ja) * 2018-12-11 2020-06-18 株式会社 バイオミメティクスシンパシーズ 腸溶性カプセル
JP6967308B1 (ja) * 2020-06-30 2021-11-17 国立大学法人高知大学 胎児付属物由来組織細胞培養上清を含む脳神経障害治療剤

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002098361A2 (en) * 2001-06-01 2002-12-12 Xcyte Therapies, Inc. T cell induced tissue repair and regeneration

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
DONYA NAZARINIA等: "Conditioned medium obtained from human amniotic mesenchymal stem cells attenuates focal cerebral ischemia/reperfusion injury in rats by targeting mTOR pathway", JOURNAL OF CHEMICAL NEUROANATOMY, vol. 102, 6 January 2019 (2019-01-06), pages 2 *
李洪秋;崔丹;阿良;赵忠海;陈宾;: "人胎盘间充质干细胞移植对大鼠脊髓损伤区bFGF表达的影响", 辽宁医学院学报, no. 02, 15 April 2010 (2010-04-15) *

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JP2022016722A (ja) 2022-01-24
US20230242870A1 (en) 2023-08-03
EP4173629A4 (en) 2024-08-21
EP4173629A1 (en) 2023-05-03
JPWO2022004816A1 (https=) 2022-01-06
JP6967308B1 (ja) 2021-11-17
WO2022004816A1 (ja) 2022-01-06

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Application publication date: 20230317