CN115803324A - 纯化(-)-降龙涎香醚的方法 - Google Patents

纯化(-)-降龙涎香醚的方法 Download PDF

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Publication number
CN115803324A
CN115803324A CN202180049244.7A CN202180049244A CN115803324A CN 115803324 A CN115803324 A CN 115803324A CN 202180049244 A CN202180049244 A CN 202180049244A CN 115803324 A CN115803324 A CN 115803324A
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CN
China
Prior art keywords
crude
ambrox
equal
washing
fragrance
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Pending
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CN202180049244.7A
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English (en)
Chinese (zh)
Inventor
J-P·巴拉斯
S·莫雷
E·艾克霍恩
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Givaudan SA
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Givaudan SA
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Publication of CN115803324A publication Critical patent/CN115803324A/zh
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y504/00—Intramolecular transferases (5.4)
    • C12Y504/99—Intramolecular transferases (5.4) transferring other groups (5.4.99)
    • C12Y504/99017—Squalene--hopene cyclase (5.4.99.17)
    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11B—PRODUCING, e.g. BY PRESSING RAW MATERIALS OR BY EXTRACTION FROM WASTE MATERIALS, REFINING OR PRESERVING FATS, FATTY SUBSTANCES, e.g. LANOLIN, FATTY OILS OR WAXES; ESSENTIAL OILS; PERFUMES
    • C11B9/00—Essential oils; Perfumes
    • C11B9/0069—Heterocyclic compounds
    • C11B9/0073—Heterocyclic compounds containing only O or S as heteroatoms
    • C11B9/0076—Heterocyclic compounds containing only O or S as heteroatoms the hetero rings containing less than six atoms
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/90—Isomerases (5.)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/02—Oxygen as only ring hetero atoms
    • C12P17/04—Oxygen as only ring hetero atoms containing a five-membered hetero ring, e.g. griseofulvin, vitamin C
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/92—Naphthofurans; Hydrogenated naphthofurans

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Fats And Perfumes (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Cosmetics (AREA)
CN202180049244.7A 2020-07-30 2021-07-29 纯化(-)-降龙涎香醚的方法 Pending CN115803324A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB2011823.8 2020-07-30
GBGB2011823.8A GB202011823D0 (en) 2020-07-30 2020-07-30 Method
PCT/EP2021/071246 WO2022023464A1 (en) 2020-07-30 2021-07-29 Method for purifying (-)-ambrox

Publications (1)

Publication Number Publication Date
CN115803324A true CN115803324A (zh) 2023-03-14

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CN202180049244.7A Pending CN115803324A (zh) 2020-07-30 2021-07-29 纯化(-)-降龙涎香醚的方法

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Country Link
US (2) US12404531B2 (https=)
EP (1) EP4188916A1 (https=)
JP (1) JP7808084B2 (https=)
CN (1) CN115803324A (https=)
BR (1) BR112023001441A2 (https=)
GB (1) GB202011823D0 (https=)
MX (1) MX2022014988A (https=)
WO (1) WO2022023464A1 (https=)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN119137269A (zh) 2022-03-17 2024-12-13 奇华顿股份有限公司 Shc酶和酶变体
GB202313239D0 (en) * 2023-08-31 2023-10-18 Givaudan Sa Organic compounds

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102317274A (zh) * 2009-02-16 2012-01-11 花王株式会社 制造(±)-3a,6,6,9a-四甲基十二氢萘并[2,1-b]呋喃的方法
CN107548418A (zh) * 2015-04-24 2018-01-05 奇华顿股份有限公司 分离和纯化降龙涎醚的方法
CN107567500A (zh) * 2015-04-24 2018-01-09 奇华顿股份有限公司 酶及其应用
CN109071480A (zh) * 2016-04-22 2018-12-21 奇华顿股份有限公司 在生物催化剂存在下通过高法呢醇的生物转化形成的(-)-降龙涎香醚的固体形式
CN110312796A (zh) * 2017-02-24 2019-10-08 国际香料和香精公司 角鲨烯何帕烯环化酶及其用于生产降龙涎香醚的用途

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS58117294A (ja) * 1981-12-30 1983-07-12 ライオン株式会社 芳香性洗剤組成物
JPS60239481A (ja) 1984-05-14 1985-11-28 T Hasegawa Co Ltd （±）−アンブロツクスの製法及びその利用
DE3912318A1 (de) 1989-04-14 1990-10-18 Henkel Kgaa Verfahren zur stereoselektiven herstellung von 8(alpha),12-oxido-13,14,15,16-tetranorlabdan
US4970163A (en) 1989-08-28 1990-11-13 International Flavors & Fragrances Inc. Process for producing diol and lactone and microorganisms capable of same
US5290955A (en) 1991-12-29 1994-03-01 Kuraray Co., Ltd. Process for producing L-ambrox
DE4341275A1 (de) 1993-12-03 1995-06-08 Henkel Kgaa Verfahren zur Herstellung von 8alpha,12-Oxido-13,14,15,16-tetranorlabdan
JP4773336B2 (ja) * 2003-02-20 2011-09-14 エーザイ・アール・アンド・ディー・マネジメント株式会社 Ｌｐｓアンタゴニストｂ１２８７およびその立体異性体の調製のための試薬および方法
JP5137834B2 (ja) * 2006-07-20 2013-02-06 旭化成ファーマ株式会社 置換フェニルアルカン酸の新規結晶及び製造方法
WO2012054097A1 (en) * 2010-10-19 2012-04-26 Future Fuel Chemical Company Use of an acetic acid wash to prepare low-sulfate 5-sulfoisophthalic acid, mono-lithium salt
TWI463006B (zh) * 2012-03-23 2014-12-01 A processing composition for cutting hard and brittle materials and a method of cutting hard and brittle materials
JP6090377B2 (ja) * 2015-07-27 2017-03-08 栗田工業株式会社 水処理用ポリアミド系逆浸透膜用洗浄剤、洗浄液、および洗浄方法
JP7263244B2 (ja) 2017-02-24 2023-04-24 ビーエーエスエフ ソシエタス・ヨーロピア （３Ｅ，７Ｅ）－ホモファルネセン酸（ｈｏｍｏｆａｒｎｅｓｉｃ ａｃｉｄ）、または、（３Ｅ，７Ｅ）－ホモファルネセン酸エステルの製造のための方法

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102317274A (zh) * 2009-02-16 2012-01-11 花王株式会社 制造(±)-3a,6,6,9a-四甲基十二氢萘并[2,1-b]呋喃的方法
CN107548418A (zh) * 2015-04-24 2018-01-05 奇华顿股份有限公司 分离和纯化降龙涎醚的方法
CN107567500A (zh) * 2015-04-24 2018-01-09 奇华顿股份有限公司 酶及其应用
CN109071480A (zh) * 2016-04-22 2018-12-21 奇华顿股份有限公司 在生物催化剂存在下通过高法呢醇的生物转化形成的(-)-降龙涎香醚的固体形式
CN110312796A (zh) * 2017-02-24 2019-10-08 国际香料和香精公司 角鲨烯何帕烯环化酶及其用于生产降龙涎香醚的用途

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Publication number Publication date
MX2022014988A (es) 2023-01-04
US12404531B2 (en) 2025-09-02
JP2023536825A (ja) 2023-08-30
BR112023001441A2 (pt) 2023-02-14
US20260062725A1 (en) 2026-03-05
GB202011823D0 (en) 2020-09-16
EP4188916A1 (en) 2023-06-07
US20230212624A1 (en) 2023-07-06
JP7808084B2 (ja) 2026-01-28
WO2022023464A1 (en) 2022-02-03

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