CN115770203B - Modified jojoba oil and preparation method and application thereof - Google Patents
Modified jojoba oil and preparation method and application thereof Download PDFInfo
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- CN115770203B CN115770203B CN202211594403.4A CN202211594403A CN115770203B CN 115770203 B CN115770203 B CN 115770203B CN 202211594403 A CN202211594403 A CN 202211594403A CN 115770203 B CN115770203 B CN 115770203B
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- 229940119170 jojoba wax Drugs 0.000 title claims abstract description 56
- 238000002360 preparation method Methods 0.000 title claims description 32
- XYJRXVWERLGGKC-UHFFFAOYSA-D pentacalcium;hydroxide;triphosphate Chemical class [OH-].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O XYJRXVWERLGGKC-UHFFFAOYSA-D 0.000 claims abstract description 61
- 229920001661 Chitosan Polymers 0.000 claims abstract description 51
- 239000007788 liquid Substances 0.000 claims abstract description 46
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims abstract description 38
- 229910021389 graphene Inorganic materials 0.000 claims abstract description 38
- 239000003242 anti bacterial agent Substances 0.000 claims abstract description 32
- 239000004094 surface-active agent Substances 0.000 claims abstract description 26
- 239000003795 chemical substances by application Substances 0.000 claims abstract description 24
- 229910052588 hydroxylapatite Inorganic materials 0.000 claims abstract description 14
- 238000003756 stirring Methods 0.000 claims description 66
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims description 36
- 239000000463 material Substances 0.000 claims description 31
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 claims description 24
- 229910052761 rare earth metal Inorganic materials 0.000 claims description 22
- 150000002910 rare earth metals Chemical class 0.000 claims description 22
- 239000000047 product Substances 0.000 claims description 21
- 229920001184 polypeptide Polymers 0.000 claims description 19
- 102000004196 processed proteins & peptides Human genes 0.000 claims description 19
- 108090000765 processed proteins & peptides Proteins 0.000 claims description 19
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 18
- 238000005406 washing Methods 0.000 claims description 14
- AEMRFAOFKBGASW-UHFFFAOYSA-N Glycolic acid Chemical compound OCC(O)=O AEMRFAOFKBGASW-UHFFFAOYSA-N 0.000 claims description 12
- 238000006243 chemical reaction Methods 0.000 claims description 12
- 238000001035 drying Methods 0.000 claims description 12
- 238000002156 mixing Methods 0.000 claims description 12
- 239000002002 slurry Substances 0.000 claims description 12
- 238000011282 treatment Methods 0.000 claims description 12
- 241001523681 Dendrobium Species 0.000 claims description 11
- 238000010438 heat treatment Methods 0.000 claims description 10
- 238000001816 cooling Methods 0.000 claims description 7
- IXPNQXFRVYWDDI-UHFFFAOYSA-N 1-methyl-2,4-dioxo-1,3-diazinane-5-carboximidamide Chemical compound CN1CC(C(N)=N)C(=O)NC1=O IXPNQXFRVYWDDI-UHFFFAOYSA-N 0.000 claims description 6
- 108010059892 Cellulase Proteins 0.000 claims description 6
- 239000006087 Silane Coupling Agent Substances 0.000 claims description 6
- BQCADISMDOOEFD-UHFFFAOYSA-N Silver Chemical group [Ag] BQCADISMDOOEFD-UHFFFAOYSA-N 0.000 claims description 6
- DBMJMQXJHONAFJ-UHFFFAOYSA-M Sodium laurylsulphate Chemical compound [Na+].CCCCCCCCCCCCOS([O-])(=O)=O DBMJMQXJHONAFJ-UHFFFAOYSA-M 0.000 claims description 6
- 229940106157 cellulase Drugs 0.000 claims description 6
- 239000002131 composite material Substances 0.000 claims description 6
- 239000008367 deionised water Substances 0.000 claims description 6
- 229910021641 deionized water Inorganic materials 0.000 claims description 6
- 125000000373 fatty alcohol group Chemical group 0.000 claims description 6
- 239000000706 filtrate Substances 0.000 claims description 6
- 238000001914 filtration Methods 0.000 claims description 6
- 238000004108 freeze drying Methods 0.000 claims description 6
- ICAKDTKJOYSXGC-UHFFFAOYSA-K lanthanum(iii) chloride Chemical compound Cl[La](Cl)Cl ICAKDTKJOYSXGC-UHFFFAOYSA-K 0.000 claims description 6
- 239000012528 membrane Substances 0.000 claims description 6
- 239000000203 mixture Substances 0.000 claims description 6
- 238000002715 modification method Methods 0.000 claims description 6
- 238000001728 nano-filtration Methods 0.000 claims description 6
- 229940051841 polyoxyethylene ether Drugs 0.000 claims description 6
- 229920000056 polyoxyethylene ether Polymers 0.000 claims description 6
- 238000010298 pulverizing process Methods 0.000 claims description 6
- 229910052708 sodium Inorganic materials 0.000 claims description 6
- 239000011734 sodium Substances 0.000 claims description 6
- 235000010413 sodium alginate Nutrition 0.000 claims description 6
- 239000000661 sodium alginate Substances 0.000 claims description 6
- 229940005550 sodium alginate Drugs 0.000 claims description 6
- -1 sodium alkyl sulfonate Chemical class 0.000 claims description 6
- 238000000034 method Methods 0.000 claims description 4
- 230000000844 anti-bacterial effect Effects 0.000 abstract description 16
- 230000002195 synergetic effect Effects 0.000 abstract description 4
- 239000011159 matrix material Substances 0.000 abstract description 2
- 238000012986 modification Methods 0.000 abstract description 2
- 230000004048 modification Effects 0.000 abstract description 2
- 238000005457 optimization Methods 0.000 abstract description 2
- 230000000052 comparative effect Effects 0.000 description 8
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 5
- 239000000741 silica gel Substances 0.000 description 5
- 229910002027 silica gel Inorganic materials 0.000 description 5
- 238000012360 testing method Methods 0.000 description 4
- 241000221095 Simmondsia Species 0.000 description 3
- 235000004433 Simmondsia californica Nutrition 0.000 description 3
- 241000191967 Staphylococcus aureus Species 0.000 description 2
- 230000001580 bacterial effect Effects 0.000 description 2
- 239000002537 cosmetic Substances 0.000 description 2
- 239000002994 raw material Substances 0.000 description 2
- DNISEZBAYYIQFB-PHDIDXHHSA-N (2r,3r)-2,3-diacetyloxybutanedioic acid Chemical compound CC(=O)O[C@@H](C(O)=O)[C@H](C(O)=O)OC(C)=O DNISEZBAYYIQFB-PHDIDXHHSA-N 0.000 description 1
- 241000894006 Bacteria Species 0.000 description 1
- 241000196324 Embryophyta Species 0.000 description 1
- 235000010469 Glycine max Nutrition 0.000 description 1
- 244000068988 Glycine max Species 0.000 description 1
- 239000004169 Hydrogenated Poly-1-Decene Substances 0.000 description 1
- 230000003385 bacteriostatic effect Effects 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 235000019383 crystalline wax Nutrition 0.000 description 1
- 238000012258 culturing Methods 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 230000006866 deterioration Effects 0.000 description 1
- 238000007865 diluting Methods 0.000 description 1
- 238000011156 evaluation Methods 0.000 description 1
- 229940127554 medical product Drugs 0.000 description 1
- 239000003921 oil Substances 0.000 description 1
- 239000002453 shampoo Substances 0.000 description 1
- 239000000344 soap Substances 0.000 description 1
- 229940084106 spermaceti Drugs 0.000 description 1
- 239000012177 spermaceti Substances 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 230000037072 sun protection Effects 0.000 description 1
- 239000012137 tryptone Substances 0.000 description 1
Classifications
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Cosmetics (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
The invention discloses a modified jojoba oil, which comprises jojoba oil, a surfactant, modified hydroxyapatite, chitosan coordination liquid and an antibacterial agent, wherein the mass ratio of the jojoba oil to the surfactant to the modified hydroxyapatite to the chitosan coordination liquid to the antibacterial agent is as follows: (10-15): (2-5): (1-3): (3-5):2. The modified jojoba oil disclosed by the invention takes jojoba oil as a matrix, is assisted by adding the modified hydroxyapatite and chitosan coordination liquid, is adhered to an acting surface through the surface porous property of the hydroxyapatite, is subjected to the synergistic optimization modification of the graphene agent, is modified by the combined action of the modified hydroxyapatite and the chitosan coordination liquid, and is synergistic, so that the antibacterial effect of the product is enhanced, and the antibacterial stability and durability of the product are improved.
Description
Technical Field
The invention relates to the technical field of modified jojoba oil, in particular to modified jojoba oil and a preparation method and application thereof.
Background
Jojoba is also called jojoba, is a native plant in mexico, is planted worldwide at present, but is most suitable for growth and excellent in quality by taking desert terrains at the ink-jet junction. Can be used in cosmetics to make into various hair care, skin care, bath sun protection and medical products. The recommended use amount of the skin care product is 5% -10%, the shampoo and the hair conditioner are 1% -2%, and the soap is 0.5% -3%. Hydrogenated jojoba oil is a hard crystalline wax that can replace spermaceti. Ethoxylated and propoxylated water-soluble jojoba oils have also begun to find use in a variety of cosmetics.
The traditional jojoba oil and diacetyl tartaric acid mono-diglyceride and other raw materials are matched for the hand sanitizer, but the raw material combination has poor antibacterial efficiency and is not durable in antibacterial effect, so that bacteria are bred, and the antibacterial efficiency is affected.
Disclosure of Invention
Aiming at the defects of the prior art, the invention aims to provide modified jojoba oil, a preparation method and application thereof, so as to solve the problems in the prior art.
The invention solves the technical problems by adopting the following technical scheme:
the invention provides modified jojoba oil, which comprises jojoba oil, a surfactant, modified hydroxyapatite, chitosan coordination liquid and an antibacterial agent, wherein the mass ratio of the jojoba oil to the surfactant to the modified hydroxyapatite to the chitosan coordination liquid to the antibacterial agent is as follows: (10-15): (2-5): (1-3): (3-5):2.
Preferably, the surfactant is fatty alcohol polyoxyethylene ether and the antibacterial agent is nano silver antibacterial agent.
Preferably, the modification method of the modified hydroxyapatite comprises the following steps:
s01: heating hydroxyapatite at 200-220 deg.c for 5-10min, and then heating at 2-5 deg.c/min to room temperature;
s02: adding the mixture into hydrochloric acid solution according to a weight ratio of 1:6, then adding sodium alkyl sulfonate accounting for 5-10% of the total amount of the hydroxyapatite and sodium alginate accounting for 1-5%, and uniformly stirring to obtain modified hydroxyapatite composite liquid;
s03: adding the rare earth coordinated graphene agent into the S02 product according to the weight ratio of 1:6, stirring for reaction treatment, and washing and drying after stirring is finished to obtain the modified hydroxyapatite.
Preferably, the mass fraction of the hydrochloric acid solution is 5-10%.
Preferably, the preparation method of the rare earth coordinated graphene agent comprises the following steps:
adding graphene into a lanthanum chloride solution according to a weight ratio of 1:5, then adding a silane coupling agent KH560, uniformly stirring, then adding 5-10% of glycolic acid and 1-5% of sodium dodecyl sulfate in the total amount of the graphene, fully stirring, and finally washing and drying to obtain the rare earth coordinated graphene agent.
Preferably, the temperature of the stirring reaction of the S03 is 55-65 ℃, the stirring rotation speed is 300-350r/min, and the stirring time is 20-30min.
Preferably, the preparation method of the chitosan coordination liquid comprises the following steps:
adding chitosan into deionized water according to a weight ratio of 1:6, then adding citric acid, adjusting the pH value, then adding dendrobium polypeptide material accounting for 5-10% of the total chitosan, and stirring fully to obtain chitosan coordination liquid;
the preparation method of the dendrobium polypeptide material comprises the following steps:
s101: pulverizing herba Dendrobii, and adding 5-10 times of water to obtain slurry;
s102: then adding 10-15% of cellulase into the slurry, and performing enzymolysis treatment at 35 ℃ to obtain an enzymolysis material;
s103: adding 5-10 times of water into the enzymolysis material, treating with slow fire for 1-2h, cooling to room temperature, filtering with nanofiltration membrane, removing filtrate, and freeze drying to obtain herba Dendrobii polypeptide material.
Preferably, the citric acid is added and the pH value is adjusted to 5.0-6.0.
The invention discloses a preparation method of modified jojoba oil, which comprises the following steps:
and sequentially stirring and mixing jojoba oil, a surfactant, modified hydroxyapatite, chitosan coordination liquid and an antibacterial agent, and fully stirring and mixing to obtain modified jojoba oil.
The invention also provides application of the modified jojoba oil in skin care and hand sanitizer products.
Compared with the prior art, the invention has the following beneficial effects:
the modified jojoba oil disclosed by the invention takes jojoba oil as a matrix, is assisted by adding the modified hydroxyapatite and chitosan coordination liquid, is adhered to an acting surface through the surface porous property of the hydroxyapatite, is subjected to the synergistic optimization modification of the graphene agent, is modified by the combined action of the modified hydroxyapatite and the chitosan coordination liquid, and is synergistic, so that the antibacterial effect of the product is enhanced, and the antibacterial stability and durability of the product are improved.
Detailed Description
The following description of the embodiments of the present invention will be made clearly and fully with reference to the accompanying drawings, in which it is evident that the embodiments described are only some, but not all embodiments of the invention. All other embodiments, which can be made by those skilled in the art based on the embodiments of the invention without making any inventive effort, are intended to be within the scope of the invention.
The modified jojoba oil of the embodiment comprises jojoba oil, a surfactant, modified hydroxyapatite, chitosan coordination liquid and an antibacterial agent, wherein the mass ratio of the jojoba oil, the surfactant, the modified hydroxyapatite, the chitosan coordination liquid and the antibacterial agent is as follows: (10-15): (2-5): (1-3): (3-5):2.
The surfactant of the embodiment is fatty alcohol polyoxyethylene ether and the antibacterial agent is nano silver antibacterial agent.
The modification method of the modified hydroxyapatite of the embodiment comprises the following steps:
s01: heating hydroxyapatite at 200-220 deg.c for 5-10min, and then heating at 2-5 deg.c/min to room temperature;
s02: adding the mixture into hydrochloric acid solution according to a weight ratio of 1:6, then adding sodium alkyl sulfonate accounting for 5-10% of the total amount of the hydroxyapatite and sodium alginate accounting for 1-5%, and uniformly stirring to obtain modified hydroxyapatite composite liquid;
s03: adding the rare earth coordinated graphene agent into the S02 product according to the weight ratio of 1:6, stirring for reaction treatment, and washing and drying after stirring is finished to obtain the modified hydroxyapatite.
The mass fraction of the hydrochloric acid solution in this example is 5-10%.
The preparation method of the rare earth coordinated graphene agent in the embodiment comprises the following steps:
adding graphene into a lanthanum chloride solution according to a weight ratio of 1:5, then adding a silane coupling agent KH560, uniformly stirring, then adding 5-10% of glycolic acid and 1-5% of sodium dodecyl sulfate in the total amount of the graphene, fully stirring, and finally washing and drying to obtain the rare earth coordinated graphene agent.
The temperature of the stirring reaction of S03 in the embodiment is 55-65 ℃, the stirring rotating speed is 300-350r/min, and the stirring time is 20-30min.
The preparation method of the chitosan coordination liquid in the embodiment comprises the following steps:
adding chitosan into deionized water according to a weight ratio of 1:6, then adding citric acid, adjusting the pH value, then adding dendrobium polypeptide material accounting for 5-10% of the total chitosan, and stirring fully to obtain chitosan coordination liquid;
the preparation method of the dendrobium polypeptide material comprises the following steps:
s101: pulverizing herba Dendrobii, and adding 5-10 times of water to obtain slurry;
s102: then adding 10-15% of cellulase into the slurry, and performing enzymolysis treatment at 35 ℃ to obtain an enzymolysis material;
s103: adding 5-10 times of water into the enzymolysis material, treating with slow fire for 1-2h, cooling to room temperature, filtering with nanofiltration membrane, removing filtrate, and freeze drying to obtain herba Dendrobii polypeptide material.
The citric acid of this example was added to adjust the pH to 5.0-6.0.
The preparation method of the modified jojoba oil comprises the following steps:
and sequentially stirring and mixing jojoba oil, a surfactant, modified hydroxyapatite, chitosan coordination liquid and an antibacterial agent, and fully stirring and mixing to obtain modified jojoba oil.
The application of the modified jojoba oil in skin care and hand sanitizer products is provided.
Example 1.
The modified jojoba oil of the embodiment comprises jojoba oil, a surfactant, modified hydroxyapatite, chitosan coordination liquid and an antibacterial agent, wherein the mass ratio of the jojoba oil, the surfactant, the modified hydroxyapatite, the chitosan coordination liquid and the antibacterial agent is as follows: 10:2:1:3:2.
The surfactant of the embodiment is fatty alcohol polyoxyethylene ether and the antibacterial agent is nano silver antibacterial agent.
The modification method of the modified hydroxyapatite of the embodiment comprises the following steps:
s01: heating hydroxyapatite at 200 deg.c for 5min, and then heating at 2 deg.c/min to room temperature;
s02: adding the mixture into hydrochloric acid solution according to a weight ratio of 1:6, then adding sodium alkyl sulfonate accounting for 5% of the total amount of the hydroxyapatite and sodium alginate accounting for 1%, and uniformly stirring to obtain modified hydroxyapatite composite liquid;
s03: adding the rare earth coordinated graphene agent into the S02 product according to the weight ratio of 1:6, stirring for reaction treatment, and washing and drying after stirring is finished to obtain the modified hydroxyapatite.
The mass fraction of the hydrochloric acid solution of this example was 5%.
The preparation method of the rare earth coordinated graphene agent in the embodiment comprises the following steps:
adding graphene into a lanthanum chloride solution according to a weight ratio of 1:5, then adding a silane coupling agent KH560, uniformly stirring, then adding 5% of glycolic acid and 1% of sodium dodecyl sulfate in the total amount of the graphene, fully stirring, and finally washing and drying to obtain the rare earth coordinated graphene agent.
The temperature of the stirring reaction in S03 of this example was 55℃and the stirring speed was 300r/min, and the stirring time was 20min.
The preparation method of the chitosan coordination liquid in the embodiment comprises the following steps:
adding chitosan into deionized water according to a weight ratio of 1:6, then adding citric acid, adjusting the pH value, then adding dendrobe polypeptide material accounting for 5% of the total chitosan, and stirring fully to obtain chitosan coordination liquid;
the preparation method of the dendrobium polypeptide material comprises the following steps:
s101: pulverizing herba Dendrobii, and adding 5 times of water to obtain slurry;
s102: then adding 10% of cellulase into the slurry, and performing enzymolysis treatment at 35 ℃ to obtain an enzymolysis material;
s103: adding 5 times of water into the enzymolysis material, treating with slow fire for 1h, cooling to room temperature, filtering with nanofiltration membrane, removing filtrate, and freeze-drying to obtain herba Dendrobii polypeptide material.
The citric acid of this example was added to adjust the pH to 5.0.
The preparation method of the modified jojoba oil comprises the following steps:
and sequentially stirring and mixing jojoba oil, a surfactant, modified hydroxyapatite, chitosan coordination liquid and an antibacterial agent, and fully stirring and mixing to obtain modified jojoba oil.
The application of the modified jojoba oil in skin care and hand sanitizer products is provided.
Example 2.
The modified jojoba oil of the embodiment comprises jojoba oil, a surfactant, modified hydroxyapatite, chitosan coordination liquid and an antibacterial agent, wherein the mass ratio of the jojoba oil, the surfactant, the modified hydroxyapatite, the chitosan coordination liquid and the antibacterial agent is as follows: 15:5:3:5:2.
The surfactant of the embodiment is fatty alcohol polyoxyethylene ether and the antibacterial agent is nano silver antibacterial agent.
The modification method of the modified hydroxyapatite of the embodiment comprises the following steps:
s01: heat-treating hydroxyapatite at 220 deg.c for 10min, and then heating to room temperature at 5 deg.c/min;
s02: adding the mixture into hydrochloric acid solution according to a weight ratio of 1:6, then adding sodium alkyl sulfonate accounting for 10% of the total amount of the hydroxyapatite and sodium alginate accounting for 5%, and uniformly stirring to obtain modified hydroxyapatite composite liquid;
s03: adding the rare earth coordinated graphene agent into the S02 product according to the weight ratio of 1:6, stirring for reaction treatment, and washing and drying after stirring is finished to obtain the modified hydroxyapatite.
The mass fraction of the hydrochloric acid solution of this example was 10%.
The preparation method of the rare earth coordinated graphene agent in the embodiment comprises the following steps:
adding graphene into a lanthanum chloride solution according to a weight ratio of 1:5, then adding a silane coupling agent KH560, uniformly stirring, then adding 10% of glycolic acid and 5% of sodium dodecyl sulfate in the total amount of the graphene, fully stirring, and finally washing and drying to obtain the rare earth coordinated graphene agent.
The temperature of the stirring reaction in S03 of this example was 65℃and the stirring speed was 350r/min, and the stirring time was 30min.
The preparation method of the chitosan coordination liquid in the embodiment comprises the following steps:
adding chitosan into deionized water according to a weight ratio of 1:6, then adding citric acid, adjusting the pH value, then adding dendrobium polypeptide material accounting for 10% of the total chitosan, and stirring fully to obtain chitosan coordination liquid;
the preparation method of the dendrobium polypeptide material comprises the following steps:
s101: pulverizing herba Dendrobii, and adding 10 times of water to obtain slurry;
s102: then adding cellulase accounting for 15% of the total amount into the slurry, and carrying out enzymolysis treatment at the temperature of 35 ℃ to obtain an enzymolysis material;
s103: adding the enzymolysis material into 10 times of water, treating with slow fire for 2 hours, cooling to room temperature, filtering with nanofiltration membrane, removing filtrate, and freeze-drying to obtain herba Dendrobii polypeptide material.
The citric acid of this example was added to adjust the pH to 6.0.
The preparation method of the modified jojoba oil comprises the following steps:
and sequentially stirring and mixing jojoba oil, a surfactant, modified hydroxyapatite, chitosan coordination liquid and an antibacterial agent, and fully stirring and mixing to obtain modified jojoba oil.
The application of the modified jojoba oil in skin care and hand sanitizer products is provided.
Example 3.
The modified jojoba oil of the embodiment comprises jojoba oil, a surfactant, modified hydroxyapatite, chitosan coordination liquid and an antibacterial agent, wherein the mass ratio of the jojoba oil, the surfactant, the modified hydroxyapatite, the chitosan coordination liquid and the antibacterial agent is as follows: 12:3:2:4:2.
The surfactant of the embodiment is fatty alcohol polyoxyethylene ether and the antibacterial agent is nano silver antibacterial agent.
The modification method of the modified hydroxyapatite of the embodiment comprises the following steps:
s01: heating hydroxyapatite at 210 deg.c for 7min, and then cooling to room temperature at 3.5 deg.c/min;
s02: adding the mixture into hydrochloric acid solution according to a weight ratio of 1:6, then adding sodium alkyl sulfonate accounting for 7.5% of the total amount of the hydroxyapatite and sodium alginate accounting for 3%, and uniformly stirring to obtain modified hydroxyapatite composite liquid;
s03: adding the rare earth coordinated graphene agent into the S02 product according to the weight ratio of 1:6, stirring for reaction treatment, and washing and drying after stirring is finished to obtain the modified hydroxyapatite.
The mass fraction of the hydrochloric acid solution of this example was 7%.
The preparation method of the rare earth coordinated graphene agent in the embodiment comprises the following steps:
adding graphene into a lanthanum chloride solution according to a weight ratio of 1:5, then adding a silane coupling agent KH560, uniformly stirring, then adding glycolic acid with the total amount of 7.5% of the graphene and sodium dodecyl sulfate with the total amount of 3%, fully stirring, and finally washing and drying to obtain the rare earth coordinated graphene agent.
The temperature of the stirring reaction in S03 of this example was 60℃and the stirring speed was 320r/min, and the stirring time was 5min.
The preparation method of the chitosan coordination liquid in the embodiment comprises the following steps:
adding chitosan into deionized water according to a weight ratio of 1:6, then adding citric acid, adjusting the pH value, then adding dendrobium polypeptide material accounting for 7.5% of the total chitosan, and stirring fully to obtain chitosan coordination liquid;
the preparation method of the dendrobium polypeptide material comprises the following steps:
s101: pulverizing herba Dendrobii, and adding 7.5 times of water to obtain slurry;
s102: then adding cellulase accounting for 12.5% of the total amount into the slurry, and carrying out enzymolysis treatment at the temperature of 35 ℃ to obtain an enzymolysis material;
s103: adding the enzymolysis material into 7.5 times of water, treating with slow fire for 1.5 hours, cooling to room temperature, filtering with nanofiltration membrane, removing filtrate, and freeze-drying to obtain herba Dendrobii polypeptide material.
The citric acid of this example was added to adjust the pH to 5.5.
The preparation method of the modified jojoba oil comprises the following steps:
and sequentially stirring and mixing jojoba oil, a surfactant, modified hydroxyapatite, chitosan coordination liquid and an antibacterial agent, and fully stirring and mixing to obtain modified jojoba oil.
The application of the modified jojoba oil in skin care and hand sanitizer products is provided.
Comparative example 1.
The difference from example 3 is that no modified hydroxyapatite was added.
Comparative example 2.
The difference from example 3 is that the rare earth coordinated graphene agent is not added in the preparation of the modified hydroxyapatite.
Comparative example 3.
The difference from example 3 is that the rare earth coordinated graphene agent is replaced with graphene.
Comparative example 4.
The difference from example 3 is that no chitosan coordinating solution was added.
Comparative example 5.
The difference from example 3 is that no dendrobe polypeptide material is added in the preparation of the chitosan coordination liquid.
Comparative example 6.
Example 2 in a slow-release durable antibacterial hand cleanser with application number 202010010651.4 was used as a reference group.
Antibacterial tests are carried out by referring to QB/T2738-2005 'evaluation method of antibacterial and bacteriostatic effect of daily chemical products';
the silica gel glove is sleeved on the hand, and the product is used for rubbing and washing the silica gel glove respectively in the simulated hand washing method, so that the silica gel glove can ensure that the rubbing force and the rubbing time are consistent. Taking the washed silica gel glove as a simulated washed hand, adopting staphylococcus aureus ATCC6538, after culturing for the third generation, diluting and preparing the concentration of 1X 104 cfu/mL by using tryptone soybean broth, dripping 20 mu L of bacterial liquid into a region with the diameter of 3cm of the silica gel glove, and testing the colony count concentration of staphylococcus aureus after 60 min; then dripping 10 mu L of bacterial liquid for 60min, and performing secondary test;
the products of examples 1-3 and comparative examples 1-6 were tested for performance as follows:
from examples 1-3 and comparative examples 1-6, the product of the invention has excellent antibacterial performance, and has excellent antibacterial durability after secondary test, and the antibacterial durability is obviously deteriorated without adding modified hydroxyapatite, and meanwhile, the antibacterial durability of the product is obviously deteriorated without adding chitosan coordination liquid, the rare earth coordination graphene agent is not added in the preparation of the modified hydroxyapatite, the rare earth coordination graphene agent is replaced by graphene, and the antibacterial stability of the product is in a deterioration trend, and only the modified hydroxyapatite prepared by the method has the most obvious antibacterial effect.
It will be evident to those skilled in the art that the invention is not limited to the details of the foregoing illustrative embodiments, and that the present invention may be embodied in other specific forms without departing from the spirit or essential characteristics thereof. The present embodiments are, therefore, to be considered in all respects as illustrative and not restrictive, the scope of the invention being indicated by the appended claims rather than by the foregoing description, and all changes which come within the meaning and range of equivalency of the claims are therefore intended to be embraced therein.
Furthermore, it should be understood that although the present disclosure describes embodiments, not every embodiment is provided with a separate embodiment, and that this description is provided for clarity only, and that the disclosure is not limited to the embodiments described in detail below, and that the embodiments described in the examples may be combined as appropriate to form other embodiments that will be apparent to those skilled in the art.
Claims (3)
1. The modified jojoba oil is characterized by comprising jojoba oil, a surfactant, modified hydroxyapatite, chitosan coordination liquid and an antibacterial agent, wherein the mass ratio of the jojoba oil to the surfactant to the modified hydroxyapatite to the chitosan coordination liquid to the antibacterial agent is as follows: (10-15): (2-5): (1-3): (3-5) 2;
the surfactant is fatty alcohol polyoxyethylene ether and the antibacterial agent is nano silver antibacterial agent;
the modification method of the modified hydroxyapatite comprises the following steps:
s01: heating hydroxyapatite at 200-220 deg.c for 5-10min, and then heating at 2-5 deg.c/min to room temperature;
s02: adding the mixture into hydrochloric acid solution according to a weight ratio of 1:6, then adding sodium alkyl sulfonate accounting for 5-10% of the total amount of the hydroxyapatite and sodium alginate accounting for 1-5%, and uniformly stirring to obtain modified hydroxyapatite composite liquid;
s03: adding a rare earth coordinated graphene agent into an S02 product according to a weight ratio of 1:6, stirring for reaction treatment, and washing and drying after stirring is finished to obtain modified hydroxyapatite;
the mass fraction of the hydrochloric acid solution is 5-10%;
the preparation method of the rare earth coordinated graphene agent comprises the following steps:
adding graphene into a lanthanum chloride solution according to a weight ratio of 1:5, then adding a silane coupling agent KH560, uniformly stirring, then adding 5-10% of glycolic acid and 1-5% of sodium dodecyl sulfate in the total amount of the graphene, fully stirring, and finally washing and drying to obtain a rare earth coordinated graphene agent;
the temperature of the stirring reaction of the S03 is 55-65 ℃, the stirring rotating speed is 300-350r/min, and the stirring time is 20-30min;
the preparation method of the chitosan coordination liquid comprises the following steps:
adding chitosan into deionized water according to a weight ratio of 1:6, then adding citric acid, adjusting the pH value, then adding dendrobium polypeptide material accounting for 5-10% of the total chitosan, and stirring fully to obtain chitosan coordination liquid;
the preparation method of the dendrobium polypeptide material comprises the following steps:
s101: pulverizing herba Dendrobii, and adding 5-10 times of water to obtain slurry;
s102: then adding 10-15% of cellulase into the slurry, and performing enzymolysis treatment at 35 ℃ to obtain an enzymolysis material;
s103: adding 5-10 times of water into the enzymolysis material, treating with slow fire for 1-2h, cooling to room temperature, filtering with nanofiltration membrane, removing filtrate, and freeze drying to obtain herba Dendrobii polypeptide material;
the citric acid is added, and the pH value is adjusted to 5.0-6.0.
2. A process for the preparation of a modified jojoba oil as claimed in claim 1, comprising the steps of:
and sequentially stirring and mixing jojoba oil, a surfactant, modified hydroxyapatite, chitosan coordination liquid and an antibacterial agent, and fully stirring and mixing to obtain modified jojoba oil.
3. Use of a modified jojoba oil according to claim 1 or prepared by the method of claim 2 in the preparation of a skin care, hand wash product.
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