CN115769817B - Composition containing metrafenone - Google Patents
Composition containing metrafenone Download PDFInfo
- Publication number
- CN115769817B CN115769817B CN202211560130.1A CN202211560130A CN115769817B CN 115769817 B CN115769817 B CN 115769817B CN 202211560130 A CN202211560130 A CN 202211560130A CN 115769817 B CN115769817 B CN 115769817B
- Authority
- CN
- China
- Prior art keywords
- metrafenone
- composition containing
- moss
- citrus
- disease
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- AMSPWOYQQAWRRM-UHFFFAOYSA-N metrafenone Chemical compound COC1=CC=C(Br)C(C)=C1C(=O)C1=C(C)C=C(OC)C(OC)=C1OC AMSPWOYQQAWRRM-UHFFFAOYSA-N 0.000 title claims abstract description 38
- 239000005810 Metrafenone Substances 0.000 title claims abstract description 37
- 239000000203 mixture Substances 0.000 title claims abstract description 12
- LXCFILQKKLGQFO-UHFFFAOYSA-N methylparaben Chemical compound COC(=O)C1=CC=C(O)C=C1 LXCFILQKKLGQFO-UHFFFAOYSA-N 0.000 claims abstract description 25
- 241000207199 Citrus Species 0.000 claims abstract description 19
- 235000020971 citrus fruits Nutrition 0.000 claims abstract description 19
- 229960001617 ethyl hydroxybenzoate Drugs 0.000 claims abstract description 17
- NUVBSKCKDOMJSU-UHFFFAOYSA-N ethylparaben Chemical compound CCOC(=O)C1=CC=C(O)C=C1 NUVBSKCKDOMJSU-UHFFFAOYSA-N 0.000 claims abstract description 17
- GYCKQBWUSACYIF-UHFFFAOYSA-N o-hydroxybenzoic acid ethyl ester Natural products CCOC(=O)C1=CC=CC=C1O GYCKQBWUSACYIF-UHFFFAOYSA-N 0.000 claims abstract description 8
- 239000004480 active ingredient Substances 0.000 claims abstract description 4
- QPJVMBTYPHYUOC-UHFFFAOYSA-N Methyl benzoate Natural products COC(=O)C1=CC=CC=C1 QPJVMBTYPHYUOC-UHFFFAOYSA-N 0.000 claims abstract description 3
- 229940095102 methyl benzoate Drugs 0.000 claims abstract description 3
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims abstract description 3
- 235000010270 methyl p-hydroxybenzoate Nutrition 0.000 claims description 10
- 239000004292 methyl p-hydroxybenzoate Substances 0.000 claims description 10
- 229960002216 methylparaben Drugs 0.000 claims description 10
- 235000010228 ethyl p-hydroxybenzoate Nutrition 0.000 claims description 9
- 239000004403 ethyl p-hydroxybenzoate Substances 0.000 claims description 9
- 230000000694 effects Effects 0.000 abstract description 21
- 230000001717 pathogenic effect Effects 0.000 abstract description 8
- 241000195493 Cryptophyta Species 0.000 abstract description 7
- 241000195649 Chlorella <Chlorellales> Species 0.000 abstract description 6
- 239000000575 pesticide Substances 0.000 abstract description 5
- 230000002195 synergetic effect Effects 0.000 abstract description 4
- 238000002360 preparation method Methods 0.000 abstract description 2
- 201000010099 disease Diseases 0.000 description 20
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 20
- 239000003814 drug Substances 0.000 description 13
- 238000011282 treatment Methods 0.000 description 11
- 229940079593 drug Drugs 0.000 description 9
- 230000002265 prevention Effects 0.000 description 9
- 238000011835 investigation Methods 0.000 description 6
- 230000000844 anti-bacterial effect Effects 0.000 description 5
- 238000012360 testing method Methods 0.000 description 5
- 239000003899 bactericide agent Substances 0.000 description 4
- 239000000126 substance Substances 0.000 description 4
- 241000196324 Embryophyta Species 0.000 description 3
- 240000004808 Saccharomyces cerevisiae Species 0.000 description 3
- 150000001875 compounds Chemical class 0.000 description 3
- 235000013399 edible fruits Nutrition 0.000 description 3
- 238000005507 spraying Methods 0.000 description 3
- 241000894006 Bacteria Species 0.000 description 2
- 241000195628 Chlorophyta Species 0.000 description 2
- IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 description 2
- 206010059866 Drug resistance Diseases 0.000 description 2
- 239000003795 chemical substances by application Substances 0.000 description 2
- 238000007865 diluting Methods 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 239000010413 mother solution Substances 0.000 description 2
- 239000002420 orchard Substances 0.000 description 2
- 235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 description 2
- 229920000053 polysorbate 80 Polymers 0.000 description 2
- QELSKZZBTMNZEB-UHFFFAOYSA-N propylparaben Chemical compound CCCOC(=O)C1=CC=C(O)C=C1 QELSKZZBTMNZEB-UHFFFAOYSA-N 0.000 description 2
- 238000011160 research Methods 0.000 description 2
- 239000000243 solution Substances 0.000 description 2
- OICGFSUWXCJLCO-UHFFFAOYSA-N 1-ethylsulfonylsulfanylethane Chemical compound CCSS(=O)(=O)CC OICGFSUWXCJLCO-UHFFFAOYSA-N 0.000 description 1
- 235000004936 Bromus mango Nutrition 0.000 description 1
- 239000005760 Difenoconazole Substances 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- 241000221785 Erysiphales Species 0.000 description 1
- 239000005867 Iprodione Substances 0.000 description 1
- 239000005802 Mancozeb Substances 0.000 description 1
- 240000007228 Mangifera indica Species 0.000 description 1
- 235000014826 Mangifera indica Nutrition 0.000 description 1
- 235000009184 Spondias indica Nutrition 0.000 description 1
- 244000052616 bacterial pathogen Species 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- RWCCWEUUXYIKHB-UHFFFAOYSA-N benzophenone Chemical compound C=1C=CC=CC=1C(=O)C1=CC=CC=C1 RWCCWEUUXYIKHB-UHFFFAOYSA-N 0.000 description 1
- 239000012965 benzophenone Substances 0.000 description 1
- 235000013361 beverage Nutrition 0.000 description 1
- 210000004027 cell Anatomy 0.000 description 1
- 210000002390 cell membrane structure Anatomy 0.000 description 1
- 238000013329 compounding Methods 0.000 description 1
- 239000002537 cosmetic Substances 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 230000018109 developmental process Effects 0.000 description 1
- BQYJATMQXGBDHF-UHFFFAOYSA-N difenoconazole Chemical compound O1C(C)COC1(C=1C(=CC(OC=2C=CC(Cl)=CC=2)=CC=1)Cl)CN1N=CN=C1 BQYJATMQXGBDHF-UHFFFAOYSA-N 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 235000013305 food Nutrition 0.000 description 1
- -1 furniture Substances 0.000 description 1
- 230000035784 germination Effects 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- ONUFESLQCSAYKA-UHFFFAOYSA-N iprodione Chemical compound O=C1N(C(=O)NC(C)C)CC(=O)N1C1=CC(Cl)=CC(Cl)=C1 ONUFESLQCSAYKA-UHFFFAOYSA-N 0.000 description 1
- 239000010985 leather Substances 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 230000000813 microbial effect Effects 0.000 description 1
- 244000005700 microbiome Species 0.000 description 1
- 239000011259 mixed solution Substances 0.000 description 1
- 244000052769 pathogen Species 0.000 description 1
- 230000029553 photosynthesis Effects 0.000 description 1
- 238000010672 photosynthesis Methods 0.000 description 1
- 239000003755 preservative agent Substances 0.000 description 1
- 235000010232 propyl p-hydroxybenzoate Nutrition 0.000 description 1
- 239000004405 propyl p-hydroxybenzoate Substances 0.000 description 1
- 229960003415 propylparaben Drugs 0.000 description 1
- 230000000241 respiratory effect Effects 0.000 description 1
- 230000027756 respiratory electron transport chain Effects 0.000 description 1
- 239000007921 spray Substances 0.000 description 1
- 238000010998 test method Methods 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Landscapes
- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
The invention belongs to the technical field of pesticides, and particularly relates to a composition containing metrafenone. The active ingredients of the composition containing the metrafenone are compounded by two elements of the metrafenone and methyl or ethyl hydroxybenzoate. After being compounded with the methyl hydroxybenzoate or the ethyl hydroxybenzoate, the metrafenone and the preparation method of the invention have a synergistic effect on the citrus moss pathogenic algae species fictive chlorella within a certain mass ratio range, and can improve the control effect on the citrus moss.
Description
Technical Field
The invention belongs to the technical field of pesticides, and particularly relates to a composition containing metrafenone.
Background
In citrus orchards, it is often seen that trunks, branches, leaves and fruits, even on the ground, are covered with a layer of green "clothes", which is moss disease, the etiological agent of which is the genus fictive chlorella of the family Chlorophyta (Apatococclus lobatus). Moss is mainly damaged in the middle and lower parts of the crown, and the whole plant is damaged when serious, so that photosynthesis of the tree body and appearance and quality of fruits are seriously affected. The production is usually controlled by adopting bactericides such as mancozeb, difenoconazole, iprodione or ethylicin, and the like, and the pathogenic substances have drug resistance with long-term use of the medicines, so that the control effect is not ideal.
Benzonum is a novel bactericide of benzophenone developed by Basoff company and has the chemical name: (3-bromo-6-methoxy-2-methylphenyl) - (2, 3, 4-trimethoxy-6-methylphenyl) methanone having the structural formula:
the metrafenone is registered in a plurality of countries from 2003, has the functions of protecting, treating, eradicating and inhibiting spore production of various powdery mildew, and can strongly inhibit the germination of pathogenic bacteria spores at low concentration, and the action mechanism of the metrafenone is different from that of the currently known commercial bactericides. The research shows that the metrafenone has a certain control effect on pathogenic algae of citrus moss.
The parabens, namely the parabens, comprise methyl paraben, ethyl paraben, propyl paraben and the like, and are widely used as preservatives in daily chemical products such as foods, beverages, cosmetics, furniture, leather and the like. The parabens have a wide range of antibacterial effects on mold, yeast and bacteria, and particularly have the strongest effects on mold and yeast, and inhibit the development of mold, yeast and bacteria by acting on the activities of respiratory and electron transfer enzyme systems of microbial cells and destroying the cell membrane structures of the microorganisms.
The inventor researches that the compounding of different chemical pesticides is one of the common methods for developing new pesticides, and the inventor discovers that when the metrafenone and the methyl hydroxybenzoate or the ethyl hydroxybenzoate are compounded according to a certain mass ratio, the compound has obvious synergistic effect on the prevention and treatment of citrus moss disease pathogenic algae species fictive chlorella (Apatococclus lobatus), and no related report is found at present.
The information disclosed in this background section is only for enhancement of understanding of the general background of the invention and should not be taken as an acknowledgement or any form of suggestion that this information forms the prior art already known to a person of ordinary skill in the art.
Disclosure of Invention
The invention aims to provide a composition containing metrafenone, which can improve the control of citrus moss and delay the generation of drug resistance of pathogenic algae compared with single dose.
In order to achieve the above purpose, the present invention provides the following technical solutions:
the active ingredients of the composition containing the metrafenone are compounded by two elements of the metrafenone and methyl or ethyl hydroxybenzoate.
Preferably, the mass ratio of the metrafenone to the methylparaben is 1-10:5-1.
Preferably, the mass ratio of the metrafenone to the methylparaben is 8:1.
preferably, the mass ratio of the metrafenone to the ethylparaben is 1-9:15-1.
A second object of the present invention is to provide the use of the above composition for controlling citrus moss.
Compared with the prior art, the invention has the following beneficial effects:
after being compounded with the methyl hydroxybenzoate or the ethyl hydroxybenzoate, the metrafenone and the preparation method of the invention have a synergistic effect on the citrus moss pathogenic algae species fictive chlorella within a certain mass ratio range, and can improve the control effect on the citrus moss.
Detailed Description
The following detailed description of specific embodiments of the invention is, but it should be understood that the invention is not limited to specific embodiments.
Medicine effect in field: after the metrafenone is compounded, the control effect on citrus moss disease is achieved
1. Test agent
98% of metrafenone original drug, 99.5% of methyl hydroxybenzoate original drug and 99% of ethyl hydroxybenzoate original drug are all sold in the market.
Dissolving original dimethyl sulfoxide, diluting with 0.1% Tween-80 solution, and making into mother solution. And (3) setting a plurality of groups of proportions, and diluting each single-dose mother solution and each proportion mixed solution by using 0.1% Tween-80 until the mass concentration of the active ingredients is 50mg/L for later use.
2. Test method (refer to pesticide field efficacy test criterion (II) GB/T17980.98-2004: bactericide for preventing and controlling mango anthracnose).
In the Nanfeng orange orchard of the Guangxi Liuzhou Kangan county, the orange trees with consistent growth vigor, plant depression and common occurrence of orange moss disease are selected, and the identified pathogen is algae of the Chlorella genus of Chlorophyta.
The experiment set up multiple treatments, 3 replicates each, 2 fruit trees each. And (3) carrying out full-plant spraying test medicaments on all the treated citrus trees by adopting a spraying method in the moss disease occurrence period, so as to uniformly spray the front and back sides of citrus branches and leaves without dropping liquid medicine, and setting the spraying of equal amount of clear water as a blank control.
The test was run for 3 total disease surveys: the 1 st investigation is the investigation before the first application, and the common attack of the district plants is investigated; the 2 nd investigation was a 7d investigation after the first application; the 3 rd investigation was a 14d after the first administration investigation. 5 directions in the north and south of the east are investigated for each tree, 10 leaves are investigated for each direction, the total leaves and the leaf numbers of all stages of diseases are recorded and investigated, and the disease index and the prevention and treatment effect of each treatment are calculated.
3. Leaf disease classification table
See table 1.
TABLE 1 leaf disease Condition grading Table
| Progression of illness state | Leaf spot area |
| 0 | Leaf blade without disease spot |
| 1 | The area of the disease spots accounts for less than 10 percent of the area of the blade |
| 3 | The area of the disease spots occupies 11 of the leaf area-25％ |
| 5 | The area of the disease spots accounts for 26-50% of the area of the leaf blade |
| 7 | The area of the disease spots accounts for 51-75% of the area of the leaf blade |
| 9 | The area of the disease spots accounts for more than 75 percent of the area of the blade |
4. Calculation formula
5. Test results
See tables 2-3.
TABLE 2 prevention and treatment effects of metrafenone and methyl paraben on citrus moss diseases
From table 2, it can be seen that after 7d of the drug application, the metrafenone, the methylparaben and the different proportions of the metrafenone and the methylparaben gradually show a certain control effect on the citrus moss disease, and the control effect after 14d of the drug application is better than that after 7 d. When the medicine is applied for 14d, the prevention effect of the compound treatment of the metrafenone and the methyl paraben is 70.11-86.15%, and when the mass ratio of the metrafenone to the methyl paraben is 8:1, the prevention effect reaches the maximum; the prevention effect of the independent treatment of the metrafenone and the ethylparaben is lower than 86.15%.
TABLE 3 prevention and treatment effects of combination of metrafenone and ethylparaben on citrus moss disease
From table 3, it can be seen that after 7d of the drug application, the treatment of the metrafenone, the ethylparaben and the different proportions of the metrafenone and the ethylparaben gradually shows a certain control effect on the citrus moss disease, and the control effect after 14d of the drug application is better than that after 7 d. When the medicine is applied for 14d, the prevention effect of the compound treatment of the metrafenone and the ethylparaben is between 64.77 and 83.09 percent, and the prevention effect of the independent treatment of the metrafenone and the ethylparaben is lower than 64.77 percent.
In conclusion, after the metrafenone and the methyl hydroxybenzoate or the ethyl hydroxybenzoate are compounded, the synergistic effect is achieved on the citrus moss pathogenic algae species fictive chlorella within a certain mass ratio range, and the control effect on the citrus moss can be improved.
Claims (3)
1. The composition containing the metrafenone is characterized in that the active ingredients of the composition are compounded by metrafenone and methyl or ethyl hydroxybenzoate in a binary manner; the mass ratio of the metrafenone to the methylparaben is 2-8:1, a step of; the mass ratio of the metrafenone to the ethylparaben is 1-9:10-1.
2. The composition according to claim 1, wherein the mass ratio of metrafenone and methylparaben is 8:1.
3. use of a composition according to any one of claims 1-2 for controlling citrus moss.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202211560130.1A CN115769817B (en) | 2022-12-07 | 2022-12-07 | Composition containing metrafenone |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202211560130.1A CN115769817B (en) | 2022-12-07 | 2022-12-07 | Composition containing metrafenone |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN115769817A CN115769817A (en) | 2023-03-10 |
| CN115769817B true CN115769817B (en) | 2024-04-05 |
Family
ID=85391589
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202211560130.1A Active CN115769817B (en) | 2022-12-07 | 2022-12-07 | Composition containing metrafenone |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN115769817B (en) |
Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101766217A (en) * | 2009-01-07 | 2010-07-07 | 蒋娟 | Quince preservative |
| CN103814898A (en) * | 2014-03-07 | 2014-05-28 | 海南正业中农高科股份有限公司 | Composition containing oligosaccharide and metrafenone |
| CN103858872A (en) * | 2014-03-15 | 2014-06-18 | 海南正业中农高科股份有限公司 | Metrafenone-containing pesticide composition |
| CN109329322A (en) * | 2018-09-03 | 2019-02-15 | 新昌县田野泉养殖技术开发有限公司 | The preparation method for the fungicide that can be purified water |
| EP3824733A1 (en) * | 2019-11-19 | 2021-05-26 | Minafin sprl | Preservative agrochemical compositions |
| CN114145305A (en) * | 2021-12-24 | 2022-03-08 | 广西壮族自治区农业科学院 | Composition for preventing and treating citrus moss |
-
2022
- 2022-12-07 CN CN202211560130.1A patent/CN115769817B/en active Active
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101766217A (en) * | 2009-01-07 | 2010-07-07 | 蒋娟 | Quince preservative |
| CN103814898A (en) * | 2014-03-07 | 2014-05-28 | 海南正业中农高科股份有限公司 | Composition containing oligosaccharide and metrafenone |
| CN103858872A (en) * | 2014-03-15 | 2014-06-18 | 海南正业中农高科股份有限公司 | Metrafenone-containing pesticide composition |
| CN109329322A (en) * | 2018-09-03 | 2019-02-15 | 新昌县田野泉养殖技术开发有限公司 | The preparation method for the fungicide that can be purified water |
| EP3824733A1 (en) * | 2019-11-19 | 2021-05-26 | Minafin sprl | Preservative agrochemical compositions |
| CN114145305A (en) * | 2021-12-24 | 2022-03-08 | 广西壮族自治区农业科学院 | Composition for preventing and treating citrus moss |
Also Published As
| Publication number | Publication date |
|---|---|
| CN115769817A (en) | 2023-03-10 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN114794130B (en) | Agent for preventing and treating anthracnose of macadimia nut | |
| CN105145641B (en) | A kind of granule containing trichoderma harzianum and chitosan oligosaccharide | |
| CN103444729A (en) | Bactericidal pharmaceutical composition and applications thereof | |
| CN114145305B (en) | Composition for preventing and treating citrus moss disease | |
| CN115769817B (en) | Composition containing metrafenone | |
| CN115948301B (en) | Oligosaccharin composite microbial inoculant for preventing and controlling banana vascular wilt and application thereof | |
| CN114617127B (en) | Pesticide sterilization composition and application thereof | |
| CN113875779B (en) | Bactericide composition and preparation method thereof | |
| CN115843804A (en) | Synergistic composition for preventing and treating citrus moss | |
| CN105104382A (en) | Biological compound sterilizing composition and preparation and application thereof | |
| CN113367160B (en) | Application of trichoderma viride preparation in preventing and treating tomato gray mold | |
| CN115024320A (en) | Agricultural composition containing physcion and osthole | |
| CN115886016B (en) | Composition containing berberine | |
| CN107410315A (en) | Bactericidal composition containing kasugarnycin and terpenol | |
| CN112674103A (en) | Antibacterial composition, pesticide bactericide and method for preventing and treating diseases of crops | |
| CN107318844B (en) | Anti-phytoplasma composition containing lentinan | |
| CN109526974A (en) | Composition for efficiently preventing and treating rice blast and application method | |
| CN114711241B (en) | Sterilization composition containing flumorph and metalaxyl-M and application thereof | |
| CN108184903A (en) | A kind of chicken manure biogas slurry and bactericide compounded composition and the application in apple leaf diseases are prevented | |
| CN108651458A (en) | A kind of bactericidal composition containing carvacrol and hexaconazole | |
| CN113826635B (en) | Synergistic bactericide and application thereof | |
| CN115474608B (en) | Composition for controlling Wuta-tsai diseases and application thereof | |
| CN111466392B (en) | Bactericidal composition containing benziothiazolinone and tetraconazole and application thereof | |
| CN103636643B (en) | Thiophanate-methyl-containing sterilization composition | |
| CN109699665B (en) | Seed coating agent containing captan and application thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| GR01 | Patent grant | ||
| GR01 | Patent grant |