CN115737755B - Traditional Chinese medicine composition for dispelling effects of alcohol, preparation method and application thereof - Google Patents

Abstract

The invention discloses a traditional Chinese medicine composition for dispelling effects of alcohol, a preparation method and application thereof, and belongs to the technical field of medicines. The traditional Chinese medicine composition is prepared from the following raw materials in parts by weight: 15-25 parts of Polyporus, 10-15 parts of Poria cocos, 5-15 parts of rhizoma alismatis, 10-20 parts of fried bighead atractylodes rhizome, 10-20 parts of silybum marianum, 10-20 parts of astragalus membranaceus, 5-15 parts of glossy privet fruit, 4-8 parts of lotus plumule, 5-10 parts of dendrobium, 5-10 parts of radix ophiopogonis, 4-8 parts of dark plum, 5-10 parts of lily, 10-20 parts of bamboo leaves, 15-30 parts of cassia twig and 10-20 parts of liquorice. The application of the traditional Chinese medicine composition in preparing a medicine with an anti-alcohol effect; the application of the medicine in preparing medicines for promoting alcohol metabolism or/and relieving discomfort after alcohol drinking or/and protecting liver injury caused by alcohol or/and relieving chronic disease symptoms caused by long-term alcohol drinking. The traditional Chinese medicine composition has the effects of strengthening body resistance to eliminate pathogenic factors, protecting liver, promoting bile flow, promoting diuresis, clearing away heart-fire, relieving restlessness, tonifying stomach, strengthening spleen and dispelling alcohol toxicity, and is good in safety. The composition can promote alcohol metabolism and relieve various uncomfortable symptoms caused by drinking.

Description

Traditional Chinese medicine composition for dispelling effects of alcohol, preparation method and application thereof

Technical Field

The invention belongs to the technical field of medicines, and particularly relates to a traditional Chinese medicine composition for dispelling the effects of alcohol, a preparation method and application thereof.

Background

Alcohol has excitation and paralysis effects on human brain, and can be used for pleasurable mood, dilating blood vessel and promoting blood circulation when a small amount of alcohol is drunk, however, alcoholic cirrhosis can be caused by drinking a large amount of alcohol or drinking alcohol without restriction, and simultaneously, the burden of heart is increased, so that people are unconscious. For the compendium of materia medica: "overdrinking, killing people at a moment", the World Health Organization (WHO) has also indicated that alcoholism is the first nuisance worldwide today.

In the prior art, although the medicine with the anti-alcoholic effect can immediately solve the adverse reaction caused by drunk, the medicine can not treat or relieve diseases caused by long-term or excessive drinking, and is not suitable for being used as a medicine for conditioning viscera for a long time. Therefore, the medicine for alleviating hangover can not only relieve the symptoms after drinking and shorten the sobering time, but also relieve the chronic disease symptoms caused by long-term excessive drinking, and is a problem to be solved by the person skilled in the art.

Disclosure of Invention

The invention aims to provide a traditional Chinese medicine composition for dispelling the effects of alcohol, and the combination of the medicines in the composition can not only relieve symptoms after alcohol, promote alcohol metabolism and shorten sobering time, but also relieve chronic disease symptoms caused by long-term excessive alcohol consumption.

The second object of the present invention is to provide a method for preparing the Chinese medicinal composition.

The invention also aims at providing the application of the traditional Chinese medicine composition.

In order to achieve the above purpose, the technical scheme adopted by the invention is as follows:

the invention provides a traditional Chinese medicine composition for dispelling the effects of alcohol, which is prepared from the following raw materials in parts by weight: 15-25 parts of Polyporus, 10-15 parts of Poria cocos, 5-15 parts of rhizoma alismatis, 10-20 parts of fried bighead atractylodes rhizome, 10-20 parts of silybum marianum, 10-20 parts of astragalus membranaceus, 5-15 parts of glossy privet fruit, 4-8 parts of lotus plumule, 5-10 parts of dendrobium, 5-10 parts of radix ophiopogonis, 4-8 parts of dark plum, 5-10 parts of lily, 10-20 parts of bamboo leaves, 15-30 parts of cassia twig and 10-20 parts of liquorice.

In some embodiments of the present invention, the present invention is made from raw materials comprising, by weight: 25 parts of Polyporus, 15 parts of Poria cocos, 15 parts of rhizoma alismatis, 20 parts of fried bighead atractylodes rhizome, 20 parts of silybum marianum, 20 parts of astragalus membranaceus, 15 parts of glossy privet fruit, 8 parts of lotus plumule, 10 parts of dendrobe, 10 parts of radix ophiopogonis, 8 parts of dark plum, 10 parts of lily, 20 parts of bamboo leaves, 30 parts of cassia twig and 20 parts of liquorice.

The invention provides a traditional Chinese medicine composition for dispelling the effects of alcohol, which is prepared from the following raw materials in parts by weight: 15-30 parts of Polyporus, 10-20 parts of Poria cocos, 5-20 parts of rhizoma alismatis, 10-30 parts of fried bighead atractylodes rhizome, 10-30 parts of silybum marianum, 10-30 parts of astragalus membranaceus, 5-20 parts of glossy privet fruit, 4-12 parts of lotus plumule, 5-15 parts of dendrobium, 5-15 parts of radix ophiopogonis, 4-12 parts of dark plum, 5-15 parts of lily, 10-30 parts of bamboo leaves, 15-40 parts of cassia twig and 10-30 parts of liquorice.

In some embodiments of the present invention, the Chinese medicinal composition further comprises a pharmaceutically acceptable carrier.

In some embodiments of the invention, the traditional Chinese medicine composition is a preparation prepared by taking Polyporus, poria cocos, rhizoma alismatis, stir-fried rhizoma atractylodis macrocephalae, silybum marianum, radix astragali, glossy privet fruit, lotus plumule, dendrobe, dwarf lilyturf tuber, dark plum, lily, bamboo leaves, cassia twig and liquorice as raw material medicines and adding pharmaceutically acceptable auxiliary materials according to a conventional method.

In some embodiments of the invention, the formulation is an oral formulation;

preferably, the formulation is a solid formulation;

more preferably an oral solid formulation.

The preparation method of the traditional Chinese medicine composition provided by the invention comprises the following steps:

step 1, decocting astragalus, glossy privet fruit, lotus plumule, dendrobium, dwarf lilyturf tuber and liquorice in water, filtering decoction, adding ethanol for precipitation, filtering, and concentrating filtrate into extract I for later use;

step 2, reflux extracting Polyporus, poria, alismatis rhizoma, parched Atractylodis rhizoma, mume fructus, bulbus Lilii, folium Bambusae and ramulus Cinnamomi with ethanol, filtering, recovering ethanol from filtrate, and concentrating to obtain extract II;

step 3, combining the extract I and the extract II, and drying to obtain extract powder;

step 4, crushing silybum marianum into powder;

and 5, mixing the extract powder with the silybum marianum powder, and adding pharmaceutically acceptable auxiliary materials to prepare the preparation.

In some embodiments of the present invention, in the step 1, radix astragali, fructus Ligustri Lucidi, plumula Nelumbinis, herba Dendrobii, radix Ophiopogonis, and Glycyrrhrizae radix are mixed and pulverized, and then decocted with water;

preferably, the mixture is crushed to 20 meshes;

preferably, 2-3 times of distilled water is added for soaking for 1-3 hours, and then 6-8 times of water is added for decocting for 1-3 times, and each time lasts for 1-2 hours;

preferably, the ethanol is added after the decoction is combined and filtered, and the ethanol content is 75-90%.

In the step 2, polyporus, poria, alismatis rhizoma, parched Atractylodis rhizoma, mume fructus, bulbus Lilii, folium Bambusae and ramulus Cinnamomi are mixed and crushed into coarse powder, and then ethanol is added for reflux extraction;

preferably, the ethanol volume concentration for reflux extraction is 50% -80%;

preferably, ethanol with the weight 8-10 times of the weight of the medicinal materials is added;

preferably, 50% -80% ethanol is added for reflux extraction for 2-4 times, each time for 1-4 hours;

preferably, the filtrates are combined and concentrated under reduced pressure, and the relative density of the extract is 1.2-1.3 (measured by heat at 50 ℃).

Preferably, in the step 4, the silybum marianum is washed and dried and then crushed into fine powder.

The application of the traditional Chinese medicine composition in preparation of medicines with anti-alcohol effect is provided; preferably, the application in preparing the medicine for promoting alcohol metabolism or/and relieving discomfort after alcohol drinking or/and protecting liver injury caused by alcohol or/and relieving chronic disease symptoms caused by long-term alcohol drinking.

The drinking can cause disorder of transportation and transformation of body fluids in human bodies, and researches show that the commonality after drinking is manifested by inappetence, vomiting, dry mouth or sticky mouth, hypodynamia, distension in abdomen, loose stool, easy occurrence of dysphoria, somnolence and the like, which is similar to the situation of Lidong's palisade in the theory of spleen and stomach: the symptoms of excessive drinking, vomiting and phlegm, dysphoria, chest and diaphragm stuffiness and blockage, hand and foot war shake, diet reduction and difficult urination are consistent. Lidongyuan advocates that the treatment of alcoholism should be stopped at dispersing, sweating will be healed, and then Moxiao will be treated like littley urine, both of which are divided up and down to eliminate dampness. Both of Su Wen and Jue Lun and Huang Di Nei Jing (the "Su Wen and Jue Lun" and "Huang Di Nei Jing" both consider that the wine is the liquid of cooked cereal and the essence of cereal, its qi is clear and clear. Wine enters the stomach, fills and fills collaterals, and causes empty and deficiency of meridians, qi deficiency of yin and yang qi entering, and incoordination between the stomach; it can also cause gastrectasia, and cause qi movement upward to cause qi to fill the chest, and liver to float the gallbladder. The wine has the characteristics of , being bold and clear, and being capable of damaging the essence of a person after being drunk, and affecting the viscera, spleen and stomach as well as liver, gall and chest. After drinking, the urinary bladder is qi-failing to control, which results in adverse urination, and the spleen-qi is qi-failing to transform, so that body fluids cannot be retained in the mouth. Therefore, it is indicated for alcoholism mainly to harmonize spleen and stomach, induce diuresis to promote salivation, protect liver and promote bile flow.

Polyporus umbellatus of the invention is the dry sclerotium of Polyporaceae fungus Polyporus umbellatus Polyporus umbellatus (Pers.) Fries. Sweet and bland taste, mild nature, and enters spleen, kidney, lung and bladder meridian; has effects of promoting diuresis and removing dampness, and can be used for treating dysuria, edema, diarrhea, stranguria with turbid urine, and leukorrhagia. Polyporus umbellatus has diuretic effect, and can relieve hypertension caused by sodium water retention in vivo by inhibiting renal tubule reabsorption of water and sodium ion, etc. to eliminate edema. Polyporus contains Polyporus polysaccharide, has obvious liver protecting effect, and can inhibit liver injury, increase accumulation of hepatic glycogen, and promote liver cell regeneration. A large amount of acid metabolites can be produced after drinking, the acid metabolites accumulated in the muscles of the legs can cause the symptoms of soreness of the legs, and according to modern pharmacological research, polyporus can reduce the acid metabolites produced by drinking, reduce the acidity in the body and further reduce the damage of alcohol to the liver and kidney.

Poria is the dry sclerotium of Wolf, a fungus of the Polyporaceae family, poria cocos (Schw.) co. Has effects in promoting diuresis, removing dampness, invigorating spleen, and calming heart. Can be used for treating edema, oliguria, phlegm retention, palpitation, spleen deficiency, anorexia, loose stool, diarrhea, uneasiness, palpitation, and insomnia. Sweet and sour taste can benefit spleen, and qi in middle energizer can be harmonized, so that body fluid is white and raw, and mouth Jiao Shegan is thirsty. It is also indicated for lower damp-heat, stranguria, edema, deep-colored stool, lumbar and umbilicus dysfunction, and retention of pathogenic water. It is combined with Gui Zhi, bai Zhu and gan Cao to treat deficiency of middle energizer yang and stop fluid retention in chest and hypochondrium. With stir-baked Bai Zhu, it is combined with spleen and stomach tonifying, lung qi invigorating, spleen and stomach regulating, blood nourishing, tranquillizing, repercussive and diuretic effects.

The Alismatis rhizoma is dry tuber of Alisma orientale (Sam.) Juzep. Sweet, light and cold in nature, sweet and cold in nature, excreting in the kidney and bladder meridians. Has effects of promoting diuresis, removing dampness, clearing heat, eliminating turbid pathogen, and reducing blood lipid. Can be used for treating dysuria, edema, distention, diarrhea, oliguria, dizziness due to phlegm and fluid, stranguria due to heat, and hyperlipidemia. It is indicated for damp-heat in lower energizer, phlegm-fluid retention and fire-induced delusions because it can both promote diuresis and remove dampness and clear kidney (phase) fire and bladder heat. It is combined with Fu Ling, zhu Ling and Bai Zhu to treat edema and dysuria due to internal stagnation of water-dampness. It is combined with Bai Zhu to treat dizziness due to phlegm-fluid retention and accumulation and clear yang failing to rise.

The parched Atractylodis rhizoma is processed product of Atractylodis rhizoma, and Atractylodis rhizoma is dried rhizome of Atractylodis rhizoma Atractylodes macrocephala Koidz of Compositae. The stir-baked Bai Zhu is sweet in flavor, warm in nature and middle energizer, bitter in flavor and dry in dampness, and enters spleen and stomach meridians. Can be used for treating spleen deficiency, anorexia, abdominal distention, diarrhea, phlegm retention, dizziness, palpitation, edema, spontaneous perspiration, and fetal movement. Has effects in invigorating spleen, invigorating qi, eliminating dampness, promoting diuresis, relieving sweat, enhancing cellular immunity, promoting urination, protecting liver, resisting tumor, promoting bile flow, lowering blood sugar, inhibiting bacteria, relieving cough, and tranquilizing mind. Ramulus Cinnamomi and Poria are used for treating phlegm retention; is combined with Poria and Alismatis rhizoma to treat edema. Radix astragali is combined for spontaneous sweating due to qi deficiency.

The Silybum marianum is the dried mature fruit of Silybum marianum (L.) Gaertn. It is bitter and cool in nature and has the actions of clearing heat and removing toxicity, soothing liver and promoting bile flow. It is often used for damp-heat in liver and gallbladder, hypochondriac pain and jaundice. Has good curative effects on acute or chronic hepatitis, liver cirrhosis, fatty liver, toxic liver injury in metabolism, cholelithiasis, cholangitis, perihepatic and biliary inflammation, and can rapidly improve subjective symptoms and partial abnormal biochemical indexes of liver disease patients. Experiments prove that the silybum marianum has obvious protective effect on liver injury caused by wine,

the radix astragali is dried root of Mongolian radix astragali Astragalus membranaceus (Fisch.) bge.var. Monghlicus (bge.) Hsiao or Astragalus membranaceus Astragalus membranaceus (Fisch.) bge. Invigorating spleen and replenishing middle warmer, raising yang and lifting sinking, tonifying and strengthening the exterior, promoting urination, expelling toxin and promoting granulation. Astragalus root has the functions of raising cellular immunity of chronic hepatitis patient, eliminating HPV and raising blood immunological reaction. The astragalus root is used for dispelling the effects of alcohol, has the effects of tonifying qi and dredging collaterals, and can improve numbness of limbs, general weakness, fluid deficiency, diabetes and the like caused by drunk.

In the composition, astragalus root is a qi-tonifying medicine, and has the effects of tonifying qi and promoting diuresis for treating qi-deficiency edema, poria cocos is a diuresis-promoting and dampness-excreting medicine and has the effect of tonifying spleen, and the effects of tonifying qi, tonifying spleen and promoting diuresis are enhanced after the combination.

Fructus Ligustri Lucidi is dry mature fruit of Ligustrum lucidum ait Ligustrum lucidum Ait. Liver and kidney tonifying, waist and knee strengthening. For yin deficiency and internal heat, dizziness, blurred vision, tinnitus, soreness and weakness of waist and knees, premature graying of hair and beard. Nourishing liver and kidney, improving eyesight and blackening hair. It is combined with Huang Qi to tonify qi and nourish yin, and is used for treating deficiency of qi and yin after drinking, and accelerating recovery of various functions after drinking. Oleanolic acid contained in fructus Ligustri Lucidi has remarkable protective effect on acute liver injury caused by carbon tetrachloride, and can reduce accumulation of serum alanine aminotransferase and liver triglyceride, promote liver cell regeneration, and prevent liver cirrhosis.

Plumula Nelumbinis is the dried young leaf and radicle of mature seed of Nelumbo nucifera Gaertn. Plumula Nelumbinis is an astringent for treating heat entering pericardium, coma, delirium, heart-kidney disharmony, insomnia, spermatorrhea, and hematemesis due to blood heat. Has effects of clearing heart fire, tranquilizing mind, relieving cough, eliminating phlegm, protecting liver, lung and kidney, and protecting central nervous system. The lotus plumule can effectively remove the moisture and hot air in the body after drinking, improve the immunity and resistance of human body, and nourish heart and strengthen brain.

The herba Dendrobii is a dry stem of similar species of Dendrobium nobile Dendrobium nobile Lindl, dendrobium chrysotoxum Dendrobium chrysotoxum Lindl, or Dendrobium frigidum Dendrobium fimbriatum hook. Dendrobium nobile is sweet, slightly salty and cold in nature, enters stomach, kidney and lung meridian. Has effects of benefiting stomach, promoting salivation, nourishing yin, and clearing heat. Can be used for treating yin deficiency, dry mouth, polydipsia, anorexia, retching, deficiency heat after illness, and dim eyesight. Dendrobium nobile and glossy privet fruit are combined together to achieve the effects of nourishing yin, clearing heat and nourishing stomach and tonifying kidney.

The radix Ophiopogonis is dried root tuber of Ker-Gawl of lilyturf tuber Ophiopogon japonicus (L.f) of Liliaceae. Has effects of invigorating stomach, promoting salivation, clearing away heart-fire, and relieving restlessness. It is good at treating dysphoria with smothery sensation, diabetes, heat disease, fluid consumption, dry throat and dry mouth. The stir-fried atractylodes macrocephala and dwarf lilyturf tuber are combined for tonifying the stomach and strengthening the spleen, promoting the production of body fluid and relieving restlessness when treating polydipsia and wanting to drink caused by drinking, and the chest and diaphragm is filled with obstruction.

The mume fructus is dry near mature fruit of Prunus mume of Rosaceae. Sour taste, flat. The main descending qi is to remove heat and smooths the heart. Can be used for ascending and descending, relieving restlessness and quenching thirst, relieving diarrhea and regulating stomach and middle energizer, and arresting vomiting and sweating. The dark plum fruit has the function of contracting the gall bladder, can promote bile excretion, and can prevent abnormal bile secretion and hepatic cell injury caused by drunk influence.

The lily is dried fleshy scale leaf of Lilium schoendole Lilium lancifolium thunder et al, lilium brownii f.e. brown var.

Dried stem and leaf of bamboo She Weihe family plant lophatherum gracile Lophatherum gracile brongn. Mainly clearing heat, promoting the production of body fluid, tonifying qi and harmonizing stomach. Clearing heat and relieving restlessness, promoting fluid production and promoting urination, removing fire and resolving phlegm, entering pericardium meridian, and treating dysphoria, polydipsia, coma and delirium caused by excessive drinking. The action of taking qi to clear the lung is to clear the heat of qi. The unique cool and refreshing property is released, so that pathogenic heat is not retained, and the true qi slowly grows inwards, so that the organism is recovered.

Ramulus Cinnamomi is dried twig of Cinnamomum cassia Cinnamomum cassia Presl belonging to Lauraceae. Pungent and sweet. It enters heart, lung and bladder meridians. Induce sweat to relieve muscle, warm and unblock meridians, strengthen yang and transform qi, calm pulse and reduce qi. Ramulus Cinnamomi has effects of dispersing yang in heart and chest, and warming yin qi of middle-lower jiao, and can activate yang and reduce adverse qi, so ramulus Cinnamomi has effects of warming yang and qi to promote diuresis, relieving exterior syndrome and eliminating pathogenic factors to eliminate exterior pathogenic factors. It is often combined with Bai Zhu, fu Ling and gan Cao to warm spleen yang, dispel dampness and promote diuresis, and combined with Fu Ling, alismatis rhizoma and Polyporus to promote yang, qi and promote diuresis.

In the formula of the invention, astragalus root is good at tonifying qi and promoting blood circulation, and cassia twig is good at warming channels and promoting blood circulation. The two medicines are compatible, so that deficiency of qi and blood, muscular pain, numbness of shoulder and arm and the like caused by drinking are relieved, and the effects of strengthening the whole formula of qi-tonifying, dredging collaterals, warming channels and regulating blood are achieved.

Glycyrrhrizae radix is dry root and rhizome of Glycyrrhiza uralensis Glycyrrhiza uralensis Fisch. Glycyrrhiza uralensis Glycyrrhiza inflata bat. Or Glycyrrhiza glabra Glycyrrhiza glabra L. Sweet in taste, mild in nature, and capable of tonifying qi, strengthening the middle-jiao, clearing heat, detoxicating, moistening lung, relieving cough, and also has effects of relieving spasm, pain and harmonizing drug property. Strengthening the efficacy of clearing heat and promoting urination in the prescription, promoting the discharge of alcohol in the body, relieving the burden on the liver and facilitating the alcohol elimination.

Polyporus umbellatus is reused in the formula of the traditional Chinese medicine composition, so that the traditional Chinese medicine composition has the effects of promoting diuresis, protecting liver, dispelling alcohol and accelerating acid product metabolism after hangover. Alismatis rhizoma and Poria promote diuresis and remove dampness, so that pathogenic dampness of wine can be discharged out of body along with urine, and adverse effect of urine due to dysfunction of lower jiao qi due to drinking can be treated. The stir-fried bighead atractylodes rhizome has the effects of warming stomach, dispelling cold, warming middle energizer, stopping vomiting, promoting digestion and sobering up. The silybum marianum has the effects of clearing heat and detoxicating, soothing liver and promoting bile flow, and the effective component silymarin can strengthen the stability of the outer membrane of liver cells, so that toxic substances are not easy to enter cells, and liver injury caused by various liver toxins is prevented, and the silybum marianum has the effects of protecting liver. Astragalus root, radix astragali has the effects of invigorating spleen and replenishing qi, raising yang and consolidating superficial resistance, and is good at replenishing qi and promoting blood circulation, and glossy privet fruit, fructus Ligustri Lucidi, nourishing liver and kidney, nourishing yin and tonifying qi. Plumula Nelumbinis has effects of strengthening heart and removing heat. Dendrobium nobile can nourish stomach, promote fluid production, nourish yin and clear heat. Radix Ophiopogonis has effects of benefiting stomach, promoting fluid production, clearing heart fire and relieving restlessness. Dark plum astringes lung and eliminates phlegm. Lily nourishes yin and moistens lung. Gui Zhi is pungent and warm in nature, and can dispel pathogenic factors by moving exterior and is good at warming meridians and activating collaterals. The astragalus and cassia twig are combined, so that deficiency of qi and blood, muscular pain, numbness of shoulder and arm and the like caused by drinking are relieved, and the functions of strengthening the whole formula of qi-tonifying, dredging collaterals, warming channels and regulating blood are achieved. The licorice root and cassia twig Xin Ganhua yang mainly has the effects of relieving muscles, and the bamboo She Yiqing is mainly used for treating the dysphoria and the slurred speech caused by too much drinking when combining yin and middle energizer to strengthen yang, harmonizing middle energizer to invigorate spleen, protecting liver and sobering up.

In the traditional Chinese medicine composition, polyporus, poria cocos, stir-fried rhizoma atractylodis macrocephalae and rhizoma alismatis are taken as monarch drugs, and are used for promoting diuresis and removing dampness, protecting liver and strengthening spleen, and clearing and purging damp-heat accumulation caused by alcoholism and dysuria, poria cocos and stir-fried rhizoma atractylodis macrocephalae are combined for strengthening spleen and removing dampness so as to remove phlegm-dampness after drinking, prevent vomiting and phlegm-back caused by drinking, promote diuresis without damaging yin and nourish yin without stagnation of water. Silybum marianum, astragalus membranaceus, glossy privet fruit and lotus plumule are taken as ministerial drugs, silybum marianum is used for enhancing the liver protection capability of grifola, astragalus membranaceus, glossy privet fruit and lotus plumule are added, the Fang Yi qi of the reinforcing group is used for invigorating pulse, strengthening heart and nourishing yin, and the reinforcing group is used for treating deficiency of qi and yin after drinking and accumulation of alcoholic heat and accelerating recovery of functions of viscera after drinking. Herba Dendrobii, radix Ophiopogonis, mume fructus and Bulbus Lilii are used as adjuvant drugs, radix Ophiopogonis and herba Dendrobii are used as yin nourishing and astringing liquid, and radix Ophiopogonis is used as adjuvant drugs for treating polydipsia caused by drinking with the effects of promoting fluid production, relieving restlessness, and relieving chest and diaphragm stuffiness; herba Dendrobii and radix Ophiopogonis together with herba Silybi Mariani and fructus Ligustri Lucidi can nourish liver and protect liver, nourish yin and clear heat, nourish stomach and tonify kidney; dark plum and lily are combined with stir-baked Bai Zhu for astringing lung and eliminating phlegm, nourishing yin and resolving dampness after drunk. Bamboo leaves, cassia twig and liquorice are used as guiding drugs, the bamboo She Yaoxing is cool and refreshing to be released, the cassia twig Xin Ganhua is yang, and the liquorice is qi-tonifying and middle-warming to harmonize the drug property. The recipe is to use bamboo She Liwai to ventilate and clear damp-heat, and use cassia twig to ventilate the yang of heart and chest and to warm the yin qi of the middle-lower two-jiao, so as to both ventilate the yang and reduce the adverse-rising energy, and to nourish the spleen and relieve the muscles, so as to warm the yang and qi to promote diuresis, relieve exterior syndrome and eliminate pathogenic factors, dispel exterior pathogenic factors, protect the liver and sober up, and treat vexation and dysphoria caused by drunk. The compatibility of medicines takes coordination of yin and yang as the root, and has the effects of coordinating cold and heat, both attack and tonify, ascending and descending, dispersing in astringents, combining dynamic and static phases, and coordinating yin and yang, and the purposes of strengthening body resistance and eliminating pathogenic factors, clearing heat and relieving restlessness, promoting diuresis and removing dampness, tonifying stomach and spleen, protecting liver and promoting fluid production and dispelling alcohol toxicity are achieved.

The composition is an anti-alcoholic preparation, and can be taken before and during drinking and after drinking. Compared with the prior art, the invention has the following beneficial effects:

the invention has scientific design and reasonable formula; polyporus, poria, parched Atractylodis rhizoma and Alismatis rhizoma are used as principal drugs; silybum marianum, astragalus membranaceus, glossy privet fruit and lotus plumule are used as ministerial drugs; herba Dendrobii, radix Ophiopogonis, mume fructus and Bulbus Lilii as adjuvants; bamboo leaves, cassia twig and liquorice are used as guiding drugs. The medicines are combined to have the effects of strengthening body resistance to eliminate pathogenic factors, promoting diuresis, removing dampness, clearing heart fire, relieving restlessness, invigorating stomach and spleen, and relieving alcoholism. Pharmacological experiments show that the traditional Chinese medicine composition can effectively accelerate the oxidative metabolism rate of alcohol, lighten the damage degree of alcohol to the vascular endothelial cell structure of gastric mucosa, remarkably improve the capacity of resisting oxidation and scavenging oxygen free radicals of human bodies, and has obvious inhibition effect on liver injury and gastric mucosa injury caused by drinking. Clinical practice fully proves that the formula can effectively relieve various uncomfortable symptoms caused by drinking and has the function of accelerating alcoholism.

The invention has the advantages of better expanding the application range of the composition, improving the clinical use curative effect of the composition, along with simple preparation method, better retaining the active ingredients of the medicine components, no obvious toxic or side effect, relatively low production cost, convenient administration and the like by deeply knowing the effect and the meaning of each medicine in the composition, can be taken as a daily oral preparation for dispelling or sobering up, and has wider market prospect.

Detailed Description

The present invention will now be described in further detail with reference to specific examples and the verification of pharmacological effects of the composition, which are intended to be illustrative rather than limiting. The specific conditions are not noted in the examples and are carried out according to conventional conditions or conditions recommended by the manufacturer. The reagents or apparatus used were conventional products commercially available without the manufacturer's attention.

All parts referred to in this application, unless otherwise indicated, are parts by weight.

Example 1

The embodiment discloses a preparation method of a traditional Chinese medicine composition, which comprises the following raw materials:

25 parts of Polyporus, 15 parts of Poria cocos, 15 parts of rhizoma alismatis, 20 parts of fried bighead atractylodes rhizome, 20 parts of silybum marianum, 20 parts of astragalus membranaceus, 15 parts of glossy privet fruit, 8 parts of lotus plumule, 10 parts of dendrobe, 10 parts of radix ophiopogonis, 8 parts of dark plum, 10 parts of lily, 20 parts of bamboo leaves, 30 parts of cassia twig and 20 parts of liquorice.

The preparation method of the embodiment comprises the following steps:

step 1, mixing and crushing astragalus membranaceus, glossy privet fruits, lotus plumule, dendrobium nobile, dwarf lilyturf tuber and liquorice, adding 3 times of distilled water, soaking for 2 hours, adding water, decocting for 2 times, each time for 2 hours, wherein the water for each time is 7 times of the amount of medicinal materials, merging decoction, cooling, filtering, adding ethanol into filtrate to ensure that the ethanol content is 85%, standing, precipitating, filtering, concentrating the filtrate under reduced pressure until no ethanol smell exists, and concentrating to obtain extract I for later use;

step 2, pulverizing Polyporus, poria, alismatis rhizoma, parched Atractylodis rhizoma, mume fructus, bulbus Lilii, folium Bambusae and ramulus Cinnamomi into coarse powder, reflux-extracting with 9 times of 75% ethanol for 2 times each time for 3 hr, filtering, mixing filtrates, recovering ethanol, and concentrating under reduced pressure to obtain extract II with relative density of 1.2-1.3 (50 deg.C).

Step 3, mixing the extract I with the extract II, and then spray-drying to obtain extract powder;

step 4, cleaning and drying the silybum marianum medicinal material, and crushing the silybum marianum medicinal material into 250-mesh fine powder;

and 5, uniformly mixing the extract powder obtained in the step 3 with the silybum marianum fine powder obtained in the step 4, and making into powder, and filling into capsules, wherein each capsule is filled with 0.44g, and two capsules are taken each time.

Example 2

The embodiment discloses a preparation method of a traditional Chinese medicine composition, which comprises the following raw materials: 15 parts of Polyporus, 10 parts of Poria cocos, 5 parts of rhizoma alismatis, 10 parts of fried bighead atractylodes rhizome, 10 parts of silybum marianum, 10 parts of astragalus membranaceus, 5 parts of glossy privet fruit, 4 parts of lotus plumule, 5 parts of dendrobe, 5 parts of radix ophiopogonis, 4 parts of dark plum, 5 parts of lily, 10 parts of bamboo leaves, 15 parts of cassia twig and 10 parts of liquorice.

The preparation method comprises the following steps:

step 1, mixing and crushing astragalus membranaceus, glossy privet fruits, lotus plumule, dendrobium nobile, dwarf lilyturf tuber and liquorice, adding distilled water with the amount of 2 times for soaking for 2 hours, adding water for decoction for 2 times, each time for 1 hour, each time, wherein the water for decoction is 6 times of the amount of medicinal materials, merging decoction, cooling, filtering, adding ethanol into filtrate to ensure that the alcohol content is 80%, standing, precipitating, filtering, concentrating the filtrate under reduced pressure until no alcohol taste exists, and concentrating to obtain extract I for later use;

step 2, pulverizing Polyporus, poria cocos, rhizoma alismatis, stir-fried rhizoma atractylodis macrocephalae, dark plum, lily, bamboo leaves and cassia twig into coarse powder, reflux-extracting with ethanol with the concentration of 60% for 2 times and 2.5 hours each time, filtering, combining filtrates, recovering ethanol, and concentrating under reduced pressure to obtain extract II with the relative density of 1.2-1.3 (50 ℃ heat measurement).

Step 3, mixing the extract I with the extract II, and then spray-drying to obtain extract powder;

step 4, cleaning and drying silybum marianum, and then crushing the silybum marianum into 150-mesh fine powder;

step 5, uniformly stirring the extract powder obtained in the step 3 and the fine powder of the silybum marianum obtained in the step 4 according to the weight ratio of 1:1.5 adding auxiliary materials, wherein the auxiliary materials are lactose, dextrin and stevioside in a mass ratio of 1:1:0.018, uniformly mixing, adding 90% ethanol, sieving, wet extrusion granulating and drying to obtain the final product. The granule has a specification of 8g per bag, and is taken one bag each time.

Example 3

The embodiment discloses a preparation method of a traditional Chinese medicine composition, which comprises the following raw materials: 20 parts of Polyporus, 12 parts of Poria cocos, 10 parts of rhizoma alismatis, 15 parts of fried bighead atractylodes rhizome, 15 parts of silybum marianum, 15 parts of astragalus membranaceus, 10 parts of glossy privet fruit, 6 parts of lotus plumule, 7 parts of dendrobe, 7 parts of dwarf lilyturf tuber, 6 parts of dark plum fruit, 7 parts of lily, 15 parts of bamboo leaves, 22 parts of cassia twig and 15 parts of liquorice.

The preparation method comprises the following steps:

step 1, mixing and crushing astragalus membranaceus, glossy privet fruits, lotus plumule, dendrobium nobile, dwarf lilyturf tuber and liquorice, adding distilled water with the amount of 2.5 times, soaking for 2 hours, adding water for decoction for 2 times, 1.5 hours each time, wherein the water for decoction is 7 times of the amount of medicinal materials, merging decoction, cooling, filtering, adding ethanol into filtrate to ensure that the ethanol content is 90%, standing, precipitating, filtering, concentrating the filtrate under reduced pressure until no ethanol smell exists, and concentrating to obtain extract I for later use;

step 2, pulverizing Polyporus, poria, alismatis rhizoma, parched Atractylodis rhizoma, mume fructus, bulbus Lilii, folium Bambusae and ramulus Cinnamomi into coarse powder, reflux-extracting with ethanol with concentration of 65% for 3 times and 2 hr each time, filtering, mixing filtrates, recovering ethanol, and concentrating under reduced pressure to obtain extract II with relative density of 1.2-1.3 (50 deg.C).

Step 3, mixing the extract I with the extract II, and then spray-drying to obtain extract powder;

step 4, crushing silybum marianum into 200-mesh fine powder;

step 5, uniformly stirring the extract powder obtained in the step 3 and the fine powder of the silybum marianum obtained in the step 4 according to the weight ratio of 1:1.5 adding auxiliary materials, wherein the auxiliary materials comprise isomalt and microcrystalline cellulose in a ratio of 1:3, sieving, uniformly mixing, adding an 80% ethanol solution, granulating, drying, adding 1% magnesium stearate and 1% crosslinked povidone, uniformly mixing, and sugar-coating to obtain tablets, wherein the tablet weight is 0.6g, and each time 2 tablets are taken.

Test example 1

The test example discloses an influence test of the traditional Chinese medicine composition on mice with alcoholic liver injury.

1. Medicine and grouping

60 healthy NIH mice with the mass of 18-22g are selected, and females are quarantined for 3d. Mice were randomly divided into 6 groups, namely a blank control group, a model control group and a positive control group, a composition 1 group, a composition 2 group and a composition 3 group, and 10 mice in each group.

Blank control group: filling distilled water according to 0.1ml/10g,

model control group: filling distilled water according to 0.1ml/10g,

positive control group: sea Wang Jinzun (3 g of specification is 12 tablets) produced by Shenzhen sea king health technology development Co., ltd is selected, and 0.1ml/10g of gastric lavage 0.2g/ml of anti-alcohol solution is used.

Composition 1 group the drug was a capsule prepared as in example 1, and was infused with 0.273g/ml of the composition solution at 0.1ml/10 g;

composition 2 group drug is granule prepared according to the method of example 2, and the composition solution is 0.1ml/10g gastric lavage 0.4 g/ml;

composition 3 the drug was a tablet prepared as in example 3, and a solution of the composition was infused at 0.1ml/10g and 0.2 g/ml.

2. Test method

The other groups except the blank control group are filled with 52-degree white spirit according to the amount of 15mL/kg, and after being filled with the white spirit for 30min, the corresponding medicine is filled with the stomach once a day, and the medicine is continuously administered for 7 days. The blank group was filled with the stomach and the 52 ° white spirit was replaced with an equal volume of distilled water.

Taking out eyeball blood after 12 hours after no water forbidden after the last gastric lavage, standing at room temperature, centrifuging at 2000rpm, and taking the supernatant for later use at-20 ℃; the liver is taken out quickly after the mice are killed, and the mice are preserved in an ultralow temperature refrigerator at-80 ℃ for standby.

The serum of the mice is measured by a full-automatic biochemical analyzer for AST, ALT, TP; the liver tissue was thawed and weighed to prepare a 10% homogenate, which was freeze-centrifuged at 3000rpm and examined for ADH, ALDH, SOD, GSH, MDA content using an ultraviolet-visible spectrophotometer.

3. Results

The test results are shown in Table 1.

TABLE 1 detection results of serum Biochemical indicators of each groupn=10, only

Note that: data in the table are mean value plus or minus standard error, and lower case letters after the same column of data show that the difference is obvious (P is less than 0.05); the capital letter difference indicates that the difference is extremely significant (P < 0.01).

TABLE 2 ADH and ALDH results of liver homogenates of each group [ (]n=10, only

Group of	Stomach filling material	Medicine dosage (g/kg)	ADH(U/mgprot)	ALDH(U/L)
					Blank control group	DistillationWater and its preparation method	/	36.70±0.61Aa	41.27±0.48Aa
Model control group	Distilled water	/	45.35±0.92Bb	55.15±0.34Bb
					Positive control group	Sea Wang Jinzun	2.00	57.17±0.45Cc	71.28±0.48Cc
Composition 1 group	Example 1 composition	2.73	60.27±0.47Dde	74.09±0.13Dd
					Composition 2 group	Example 2 composition	4.00	61.40±0.59De	74.99±0.45Dde
Composition 3 group	Example 3 composition	2.00	58.91±0.33CDcd	73.48±0.39De

Note that: data in the table are mean value plus or minus standard error, and lower case letters after the same column of data show that the difference is obvious (P is less than 0.05); the capital letter difference indicates that the difference is extremely significant (P < 0.01).

TABLE 3 antioxidant index detection results for liver tissue homogenates of each groupn=10, only

Note that: data in the table are mean value plus or minus standard error, and lower case letters after the same column of data show that the difference is obvious (P is less than 0.05); the capital letter difference indicates that the difference is extremely significant (P < 0.01).

4. Analysis of results

The content of AST, ALT, TP in serum liver tissue is the basis for judging whether the liver is damaged. The experimental results in table 1 show that the content of model group AST, ALT, TP after drinking is obviously higher than that of normal control group, which fully reflects the damage to liver caused by long-term drinking. The composition can obviously reduce the content of AST, ALT, TP in mouse serum liver tissue caused by ethanol, has obvious inhibition effect on liver injury caused by drinking, and has an effect obviously superior to Jiang Xiaohuang oral liquid.

The experimental results in tables 2-3 show that the composition of the invention promotes the enzyme activities of ADH and ALDH for determining the alcohol metabolism rate, accelerates the alcohol oxidation metabolism rate, obviously improves the activity of SOD and CAT with the capability of scavenging free radicals, reduces the MDA content, has better anti-alcohol effect and has obvious protection effect on liver injury caused by drinking. Jiang Xiaohuang oral liquid has the same relevant effects, but experimental results prove that the effects of the three embodiments of the composition are better than Jiang Xiaohuang oral liquid.

In conclusion, the composition has obvious inhibition effect on liver injury caused by drinking, has the effect of accelerating alcoholism, and has better effect than Jiang Xiaohuang oral liquid.

Test example 2

The test example discloses an influence test of the traditional Chinese medicine composition on gastric mucosal injury of rats suffering from acute alcoholism.

1. Medicine and grouping

60 healthy NIH mice with the mass of 18-22g are selected, and females are quarantined for 3d. Mice were randomly divided into 6 groups, namely a blank control group, a model control group and a positive control group, a composition 1 group, a composition 2 group and a composition 3 group, and 10 mice in each group.

Blank control group: filling distilled water according to 0.1ml/10g,

model control group: filling distilled water according to 0.1ml/10g,

positive control group: sea Wang Jinzun (3 g of specification is 12 tablets) produced by Shenzhen sea king health technology development Co., ltd is selected, and 0.1ml/10g of gastric lavage 0.2g/ml of anti-alcohol solution is used.

Composition 1 group the drug was a capsule prepared as in example 1, and was infused with 0.273g/ml of the composition solution at 0.1ml/10 g;

composition 2 group drug is granule prepared according to the method of example 2, and the composition solution is 0.1ml/10g gastric lavage 0.4 g/ml;

composition 3 the drug was a tablet prepared as in example 3, and a solution of the composition was infused at 0.1ml/10g and 0.2 g/ml.

2. Test method

The mice in the blank control group and the model control group are infused with distilled water in the same volume, and the other experiment groups are infused with the corresponding medicines once a day for 8 days. After dosing on day 7, fasting was carried out for 24h. After 2h of administration on day 8, the mice of each group except the blank group were treated with the same dose of 10 mL/kg ^－1 Is molded by injection of 95% ethanol. After 2h, the mice were sacrificed, the stomach was removed, and the mice were sheared off along the greater curvature of the stomach, 0.9% sodium chloride solutionRinsing, cutting seriously damaged gastric mucosa twice, homogenizing in ice 0.9mL of 0.9% sodium chloride solution in ice bath, 3000 r.min ^－1 (r=12 cm) was centrifuged for 15min, and the supernatant was taken to prepare 10% gastric tissue homogenate.

The kit is used for detecting the content of ET-1, TNF-alpha, IL-6 and PGE2 by an enzyme-linked immunosorbent assay, detecting the content of NO by a one-step method and correcting the content of protein.

3. Results

The results are shown in the following table:

TABLE 4 results of acute gastric mucosal lesion tissue homogenates ET-1 and NO for each groupn=10, only

Note that: data in the table are mean value plus or minus standard error, and lower case letters after the same column of data show that the difference is obvious (P is less than 0.05); the capital letter difference indicates that the difference is extremely significant (P < 0.01).

Table 5 TNF-alpha, IL-6 and PGE2 results for each group of gastric mucosal homogenates (ng/g,n=10, only

Note that: data in the table are mean value plus or minus standard error, and lower case letters after the same column of data show that the difference is obvious (P is less than 0.05); the capital letter difference indicates that the difference is extremely significant (P < 0.01).

4. Analysis of results

Table 4 shows that the composition of the invention can obviously reduce the abnormal increase of the ET-1 content of the gastric tissue in the acute alcoholic gastric mucosal injury process of mice, and can raise the reduced NO level of the gastric mucosa. By increasing the NO content of the gastric mucosa, reducing the ET-1 content, increasing the blood flow of blood vessels of the gastric mucosa, improving the blood circulation disorder of the gastric mucosa, enhancing the defending capability and barrier function of the gastric mucosa, and having obvious protective effect on gastric mucosa injury caused by ethanol.

Table 5 shows that the content of TNF-alpha and IL-6 in the gastric mucosa tissue of the mice in the model group is obviously higher than that in the normal control group, which indicates that the rise of TNF-alpha and IL-6 is related to gastric mucosa injury. The composition (3 groups) of the invention obviously reduces the contents of TNF-alpha and IL-6 in gastric mucosa tissues and reduces the inflammatory injury of gastric mucosa. PGE2 plays an important role in the gastric mucosa, mainly by inhibiting gastric acid and gastrin secretion and promoting mucus and bicarbonate secretion. The composition can obviously improve the content of PGE2 and has the function of protecting gastric mucosa.

In conclusion, the composition can reduce the permeability of gastric mucosa blood vessels of mice with acute alcoholic gastric mucosa injury models, improve the antioxidant capacity and the oxygen radical scavenging capacity, and reduce the damage of ethanol to vascular endothelial cell structures. The composition has obvious inhibition effect on gastric mucosa injury caused by ethanol, and the effect is obviously better than Jiang Xiaohuang oral liquid.

Conclusion: the results show that the traditional Chinese medicine composition has remarkable inhibition effect on liver injury and gastric mucosa injury caused by drinking, has a good anti-alcoholic effect, and the effect is obviously better than Jiang Xiaohuang oral liquid with better sales in the market.

Test example 3

The test example discloses an acute toxicity test (LD 50) of mice of the traditional Chinese medicine composition

Experimental materials: a powder prepared as in example 1;

animals: the weight of 40 NIH healthy adult mice is 18-22g, the clean level is achieved, the ventilation of a laboratory is good, the indoor temperature is 24+/-1 ℃, the humidity is 60+10%, the illumination of the laboratory is controlled to be 12 hours to be bright-12 hours dark, the laboratory mice are fed for one week to adapt to the environment of the laboratory, the laboratory mice are fed in separate cages, the animals can drink water freely, and the feed can be collected freely.

The test method comprises the following steps: NIH mice 40, weight 20-28g, female and male half, using Horn's method, the mice were randomly divided into 4 dose groups, and composition 21.5, 10, 4.64, 2.15g/kg (equivalent to 0.43, 0.2, 0.09g, 0.043g crude drug/kg) was administered. Fasted for 6-10 hours, and the stomach was irrigated twice on an empty stomach within 24 hours at a gastric lavage rate of 0.4mL/10g.b.w, and the two times were separated by 4 hours, and the results are shown in the following table.

The test data are shown in table 6:

table 6: LD50 test result table

The test results show that: the tested mice are orally taken with different dosages (LD 50 is more than 21.5 g/kg.b.w), and no toxic reaction is observed in the mice, so that the traditional Chinese medicine composition is a nontoxic substance.

The foregoing description of the preferred embodiments of the invention is not intended to be limiting, but rather is intended to cover all modifications, equivalents, and alternatives falling within the spirit and principles of the invention.

Claims (6)

1. The traditional Chinese medicine composition for dispelling the effects of alcohol is characterized by being prepared from the following raw materials in parts by weight: 15-25 parts of Polyporus, 10-15 parts of Poria cocos, 5-15 parts of rhizoma alismatis, 10-20 parts of fried bighead atractylodes rhizome, 10-20 parts of silybum marianum, 10-20 parts of astragalus membranaceus, 5-15 parts of glossy privet fruit, 4-8 parts of lotus plumule, 5-10 parts of dendrobium, 5-10 parts of radix ophiopogonis, 4-8 parts of dark plum, 5-10 parts of lily, 10-20 parts of bamboo leaves, 15-30 parts of cassia twig and 10-20 parts of liquorice.

2. The traditional Chinese medicine composition according to claim 1, which is characterized by being prepared from the following raw materials in parts by weight: 25 parts of Polyporus, 15 parts of Poria cocos, 15 parts of rhizoma alismatis, 20 parts of fried bighead atractylodes rhizome, 20 parts of silybum marianum, 20 parts of astragalus membranaceus, 15 parts of glossy privet fruit, 8 parts of lotus plumule, 10 parts of dendrobe, 10 parts of radix ophiopogonis, 8 parts of dark plum, 10 parts of lily, 20 parts of bamboo leaves, 30 parts of cassia twig and 20 parts of liquorice.

3. The traditional Chinese medicine composition according to claim 1 or 2, wherein the traditional Chinese medicine composition is a preparation prepared by taking Polyporus, poria cocos, rhizoma alismatis, stir-fried rhizoma atractylodis macrocephalae, silybum marianum, astragalus membranaceus, glossy privet fruit, lotus plumule, dendrobe, dwarf lilyturf tuber, dark plum fruit, lily, bamboo leaves, cassia twig and liquorice as raw material medicines and adding pharmaceutically acceptable auxiliary materials according to a conventional method.

4. The traditional Chinese medicine composition according to claim 3, wherein the preparation is an oral solid preparation.

5. The method for preparing a Chinese medicinal composition according to any one of claims 1 to 4, comprising the steps of:

step 1, mixing and crushing astragalus membranaceus, glossy privet fruit, lotus plumule, dendrobium, dwarf lilyturf tuber and liquorice to 20 meshes, adding 2-3 times of distilled water for soaking for 1-3 hours, and adding 6-8 times of water for decocting for 1-3 times, wherein each time lasts for 1-2 hours; filtering the decoction, adding ethanol for precipitation to make the ethanol content be 75% -90%, filtering, concentrating the filtrate into extract I for later use;

step 2, mixing and crushing Polyporus, poria cocos, rhizoma alismatis, stir-fried rhizoma atractylodis macrocephalae, dark plum, lily, bamboo leaves and cassia twig into coarse powder, adding ethanol with the weight of 8-10 times and the volume concentration of 50% -80% into the coarse powder, carrying out reflux extraction for 2-4 times, each time for 1-4 hours, filtering, recovering ethanol from filtrate, concentrating the filtrate under reduced pressure to obtain extract II, wherein the relative density of the extract II at 50 ℃ is 1.2-1.3, and keeping for later use;

step 3, combining the extract I and the extract II, and drying to obtain extract powder;

step 4, cleaning and drying silybum marianum, and then crushing the silybum marianum into fine powder;

and 5, mixing the extract powder with the silybum marianum powder, and adding pharmaceutically acceptable auxiliary materials to prepare the preparation.

6. Use of a Chinese medicinal composition according to any one of claims 1-4 for the preparation of a medicament for promoting alcohol metabolism or/and alleviating discomfort after alcohol consumption or/and alleviating symptoms of chronic diseases caused by long-term alcohol consumption.