CN115737734A - A composition with refreshing and antipruritic effects - Google Patents
A composition with refreshing and antipruritic effects Download PDFInfo
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- CN115737734A CN115737734A CN202211375408.8A CN202211375408A CN115737734A CN 115737734 A CN115737734 A CN 115737734A CN 202211375408 A CN202211375408 A CN 202211375408A CN 115737734 A CN115737734 A CN 115737734A
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
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Abstract
The invention discloses a cooling and itching relieving composition, which comprises the following raw materials in percentage by weight: 20 to 35 percent of ethanol solution, 0.1 to 1 percent of taraxasterol, 0.1 to 1 percent of forsythol, 0.1 to 0.5 percent of asparagine, 0.1 to 0.5 percent of aloe extract, 0.1 to 1 percent of gardenia extract, 0.1 to 0.5 percent of borneol, 0.1 to 0.3 percent of polypropylene glycol-28 butyl ether-35, 0.1 to 0.3 percent of triethanolamine or tromethamine, and the balance of water. According to the invention, the borneol and the aloe extract are used as a freshener, the taraxasterol, the forsythol, the gardenia extract and the asparagine are combined to be a relieving anti-inflammatory agent, the aloe extract is used as a humectant, and scientific proportioning is carried out, so that the strong irritation of the borneol to the skin can be reduced, a mild cooling effect can be achieved, the duration of action of the borneol and the aloe extract on skin nerve cells can be prolonged, the information receiving capability of an organism receptor on the freshener can be prolonged, the inhibition effect on various in vitro pathogenic bacteria can be achieved, the pain of the skin on burning heat and itching can be effectively relieved, and the effects of mild and rapid itching relieving can be achieved.
Description
Technical Field
The invention relates to the field of pharmaceutical chemicals, and particularly relates to a cooling and itching relieving composition.
Background
Human skin is a sensitive large organ, is also very fragile, and can cause red, swollen, itchy or painful feelings when rubbed or scratched. In summer with more mosquitoes, people can be bitten inevitably, skin after biting is easy to generate itching, and scratching can be carried out in instinctive response, particularly children scratch the skin seriously, so that the skin is damaged, and the symptoms such as skin inflammation and the like are caused, and the physical health condition of people is seriously influenced.
The existing cooling and itching relieving products mainly use mints as cooling agents, and have the problems of pungent taste, no mildness to skin, strong volatility and short duration; the existing product has the defects of crystallization separation, water-oil separation and the like in the environment with high temperature or low temperature and high water content, so that the product quality is unstable. In view of the above, it is necessary to develop a composition containing other components as a cooling agent and a humectant.
Disclosure of Invention
The invention aims to provide a cooling and itching relieving composition, which enables people to feel mild cooling, has no stimulation to skin, has lasting cooling action time, is stable to be placed for a long time, can effectively relieve discomfort caused by mosquito bites, and has a quick itching relieving effect.
The technical scheme of the invention is realized as follows:
the cooling and itching relieving composition comprises the following raw materials in percentage by weight: 20 to 35 percent of ethanol solution, 0.1 to 1 percent of taraxasterol, 0.1 to 1 percent of forsythol, 0.1 to 0.5 percent of asparagine, 0.1 to 0.5 percent of aloe extract, 0.1 to 1 percent of gardenia extract, 0.1 to 0.5 percent of borneol, 0.1 to 0.3 percent of polypropylene glycol-28 butyl ether-35, 0.1 to 0.3 percent of triethanolamine or tromethamine and the balance of water.
Preferably, the feed comprises the following raw materials in percentage by weight: 20% of ethanol solution, 0.2% of taraxasterol, 0.3% of forsythol, 0.2% of asparagine, 0.1% of aloe extract, 0.1% of gardenia extract, 0.2% of borneol, 0.1% of polypropylene glycol-28-butyl ether-35, 0.1% of triethanolamine or tromethamine and the balance of water.
Preferably, the ethanol solution has a mass concentration of 40-50%.
Preferably, the preparation method of the aloe extract comprises: cleaning appropriate amount of aloe, drying, peeling dried aloe, collecting aloe liquid, grinding the collected aloe liquid into juice, placing into a beaker, adding complex enzyme for enzymolysis, filtering by an oscillator after enzymolysis, performing reflux purification extraction after filtering, sterilizing at high temperature after qualified extraction to obtain extract, wherein the enzymolysis temperature is 39-45 ℃, the enzymolysis pH value is 4.1-5.0, and the enzymolysis time is 1.5-2.5h; the adding weight of the compound enzyme agent is 0.15-0.25% of the total weight of the aloe liquid, and the compound enzyme agent comprises the following enzymes in parts by weight: 3-5 parts of cellulase, 3-4 parts of carboxylase, 2-4 parts of glycosidase and 1.5-2.5 parts of pectinase.
Preferably, the preparation method of the aloe extract comprises: cleaning appropriate amount of aloe, drying, peeling dried aloe, collecting aloe liquid, grinding the collected aloe liquid into juice, placing into a beaker, adding complex enzyme for enzymolysis, filtering by an oscillator after enzymolysis, performing reflux purification extraction after filtering, performing high-temperature sterilization after qualified extraction to obtain an extract, wherein the enzymolysis temperature is 40-42 ℃, the enzymolysis pH value is 4.5-5.0, and the enzymolysis time is 1.8-2.3h; the adding weight of the compound enzyme agent is 0.15-0.25% of the total weight of the aloe liquid, and the compound enzyme agent comprises the following enzymes in parts by weight: 4 parts of cellulase, 3 parts of carboxylase, 3 parts of glycosidase and 2.5 parts of pectinase
The invention also provides a preparation method of the cooling and itching relieving composition, which comprises the following steps:
(1) Adding water into taraxasterol, forsythol, gardenia extract and aloe extract, heating to 43-55 ℃, stirring, adding ethanol solution, performing ultrasonic oscillation in water bath, and standing for 10-20 min to obtain a mixture A;
(2) Adding water into asparagine, borneol and polypropylene glycol-28-butyl ether-35, heating and stirring to 70-75 ℃, cooling, adding triethanolamine or tromethamine to adjust the pH value to obtain a mixture B;
(3) And taking the mixture B, and adding the mixture A under the condition of continuously stirring at 35-50 r/min to obtain the cooling and itching relieving composition.
Preferably, in the step (1), the conditions of the ultrasonic oscillation of the water bath are that the oscillation frequency is 210-250 r/min, the oscillation time is 25-35 min, and the temperature of the water bath is 30-35 ℃.
Preferably, in the step (2), the heating and stirring speed is 220-300 r/min; the temperature is reduced to 30-35 ℃ at a stirring speed of 30-50 r/min.
Taraxasterol is a taraxacum derivative, and can inhibit the expression of iNOS and COX-2 by regulating the phosphorylation levels of p38 and ERK1/2MAPKs, thereby playing an in vitro anti-inflammatory role; the forsythol is a forsythia suspense derivative, has the functions of clearing heat and removing toxicity, and has the maximum antibacterial effect on staphylococcus aureus and shigella shigelloides; asparagine has inhibitory effects on Bacillus anthracis, alpha-hemolytic streptococcus, beta-hemolytic streptococcus, corynebacterium diphtheriae, diphtheroids, streptococcus pneumoniae, staphylococcus aureus, staphylococcus citreus, staphylococcus albus, bacillus subtilis, etc. to different degrees; the aloe extract mainly contains aloe-emodin glycoside, isoaloe-emodin glycoside, aloesin, lauric acid, aloenin and other components, has the effects of treating tissue injury, protecting skin, preserving water, promoting wound healing, resisting inflammation and enhancing immunity; the fructus Gardeniae extract contains geniposide, duckwanin, jasminodin, shanzhiside, rutin, quercetin, isoquercitrin, etc., and has effects of cooling, suppressing central nervous system, tranquilizing, lowering blood pressure, relieving convulsion, and relieving pain, and has effect in inhibiting various pathogenic bacteria in vitro experiment; the borneol is obtained by steam distilling and recrystallizing stems and leaves of blumea balsamifera of Compositae or branches and leaves of cinnamomum camphora of Lauraceae, gives people a cool feeling, can refresh people's spirit, has fragrant smell, can dredge orifices in human body, dispel stagnated fire in human body, is suitable for external use, and has the functions of relieving swelling and pain; polypropylene glycol-28 butyl ether-35 is used as water retention agent.
Compared with the prior art, the invention has the beneficial effects that: according to the invention, by controlling the ethanol dosage with a certain mass concentration, taking borneol and aloe extract as a freshener, taking taraxasterol, phillyrin, gardenia extract and asparagine as a relieving and anti-inflammatory agent, taking aloe extract as a humectant and scientifically proportioning the cooling and itching relieving composition, the strong irritation of borneol to skin can be reduced, a mild cooling effect can be achieved, the duration time of the borneol and aloe extract to skin nerve cells can be prolonged, the information receiving capacity of an organism receptor to the freshener can be prolonged, the irritation of heat and itch to the skin receptor can be weakened, various pathogenic bacteria in vitro can be inhibited, the pain of skin to burning heat and itching can be effectively relieved, and the effect of mild and rapid itching relieving can be achieved.
The invention adopts a specific preparation process, realizes the effective combination of low-mass concentration ethanol solution, taraxasterol, phillyrin, gardenia extract, aloe extract, asparagine, borneol and polypropylene glycol-28-butyl ether-35, not only can improve the stability of the cooling and itching relieving composition, but also can effectively relieve the discomfort of organisms, especially the discomfort caused by mosquito bite or bacterial pruritus, and avoids the skin irritation caused by high-concentration ethanol; the invention adopts ultrasonic oscillation treatment, utilizes the mechanical waves of ultrasonic and high-frequency impact generated by oscillation, can increase the collision frequency of taraxasterol, forsythol, gardenia extract and aloe extract and low-mass concentration ethanol molecules, carries out accelerated reaction, is beneficial to the polymerization between the molecules in the solution, can ensure that the ethanol molecules are tightly combined with the molecules of the soothing anti-inflammatory agent, can also improve the uniform mixing effect of the components of the solution, avoids the precipitation of water-insoluble substances in the subsequent steps, realizes the mild and soothing itching-relieving effect of the product, and prolongs the lasting action time of the freshener on the skin.
Detailed Description
In order to make the technical means, the original characteristics, the achieved purposes and the effects of the invention easily understood, the invention is preferably described below with reference to the specific embodiments.
The experimental methods used in the examples of the present invention are all conventional methods unless otherwise specified.
The materials, reagents and the like used in the examples of the present invention can be obtained commercially without specific description.
Example 1
The cooling and itching relieving composition comprises the following raw materials in percentage by weight: 30 percent of ethanol solution with the mass concentration of 50 percent, 0.5 percent of taraxasterol, 0.5 percent of forsythol, 0.5 percent of asparagine, 0.5 percent of aloe extract, 0.5 percent of gardenia extract, 0.5 percent of borneol, 0.3 percent of polypropylene glycol-28 butyl ether-35, 0.3 percent of triethanolamine or tromethamine and the balance of water.
Example 2
The cooling and itching relieving composition comprises the following raw materials in percentage by weight: 25 percent of ethanol solution with the mass concentration of 50 percent, 0.2 percent of taraxasterol, 0.2 percent of forsythol, 0.2 percent of asparagine, 0.5 percent of aloe extract, 0.2 percent of gardenia extract, 0.1 percent of borneol, 0.1 percent of polypropylene glycol-28 butyl ether-35, 0.2 percent of triethanolamine or tromethamine and the balance of water.
Example 3
The cooling and itching relieving composition comprises the following raw materials in percentage by weight: 20% of 50% ethanol solution, 0.2% taraxasterol, 0.3% forsythol, 0.2% asparagine, 0.1% aloe extract, 0.1% gardenia extract, 0.2% borneol, 0.1% polypropylene glycol-28-butyl ether-35, 0.1% triethanolamine or tromethamine and the balance of water.
A method for preparing a cooling and itching relieving composition according to the above examples 1 to 3, comprising the steps of:
(1) Adding water into taraxasterol, forsythol, fructus Gardeniae extract and Aloe extract, heating to 43 deg.C, stirring, adding ethanol solution, ultrasonic oscillating in water bath, and standing for 20min to obtain mixture A; the conditions of the water bath ultrasonic oscillation are that the oscillation frequency is 220r/min, the oscillation time is 35min, and the water bath temperature is 35 ℃;
(2) Adding water into asparagine, borneolum Syntheticum, and polypropylene glycol-28-butyl ether-35, heating and stirring to 70 deg.C, cooling, adding triethanolamine or tromethamine to adjust pH to obtain mixture B, and heating and stirring at 220r/min; the temperature reduction is carried out to 35 ℃ at a stirring speed of 30 r/min;
(3) And taking the mixture B, and adding the mixture A under the condition of continuously stirring at 35r/min to obtain the cooling and itching relieving composition.
The preparation method of aloe extract comprises: cleaning and drying a proper amount of aloe, cutting the dried aloe into skin, collecting aloe liquid, grinding the collected aloe liquid into juice, putting the juice into a beaker, adding a complex enzyme for enzymolysis, filtering the juice by an oscillator after the enzymolysis, performing reflux purification extraction after the filtration, sterilizing the juice at 70 ℃ after the extraction is qualified, wherein the enzymolysis temperature is 40 ℃, the enzymolysis pH value is 4.7, and the enzymolysis time is 2 hours; the adding weight of the compound enzyme agent is 0.19 percent of the total weight of the aloe liquid, and the compound enzyme agent comprises the following enzymes in parts by weight: 4 parts of cellulase, 3 parts of carboxylase, 3 parts of glycosidase and 2.5 parts of pectinase.
Comparative example 1
The same preparation as in example 3 is followed, with the difference that: the composition formula has different component ratios, namely 20 percent of ethanol solution with the mass concentration of 50 percent, 0.2 percent of taraxasterol, 0.3 percent of forsythol, 0.2 percent of asparagine, 0.1 percent of gardenia extract, 0.2 percent of borneol, 0.1 percent of polypropylene glycol-28 butyl ether-35, 0.1 percent of triethanolamine or tromethamine and the balance of water.
Comparative example 2
The cooling and itching relieving composition comprises the following raw materials in percentage by weight: 20 percent of ethanol solution with the mass concentration of 50 percent, 0.3 percent of forsythol, 0.2 percent of asparagine, 0.1 percent of aloe extract, 0.1 percent of gardenia extract, 0.2 percent of borneol, 0.1 percent of polypropylene glycol-28 butyl ether-35, 0.1 percent of triethanolamine or tromethamine and the balance of water.
Comparative example 3
The cooling and itching relieving composition comprises the following raw materials in percentage by weight: 20 percent of ethanol solution with the mass concentration of 50 percent, 0.2 percent of taraxasterol, 0.3 percent of forsythol, 0.2 percent of asparagine, 0.1 percent of aloe extract, 0.1 percent of gardenia extract, 0.1 percent of polypropylene glycol-28 butyl ether-35, 0.1 percent of triethanolamine or tromethamine and the balance of water.
1. Cool and refreshing experiment
The cooling experiment method comprises the following steps: 60 volunteers were selected, 0.2g of the mild cooling and itching-relieving composition prepared in examples 1 to 3 of the present invention and comparative examples 1 to 3 was applied to the area of 3cm × 3cm inside the forearm of the left arm of the volunteer, respectively, and the cooling feeling and the time for disappearance of the cooling feeling were evaluated for a fixed period of time (0 min, 3min, 6min, 9min, 15min, 30 min). The score was 10 points full, 0 points no cooling sensation, and 10 points very strong.
The relieving experimental method comprises the following steps: 60 volunteers were selected and divided into 6 groups of 10 individuals each according to the random grouping principle. After cleaning hands, a skin area of 5cm × 5cm was reserved on the back of the left hand of a volunteer, and other skin portions were shielded, and the hands were put into a cage containing experimentally-bred culex mosquitoes and left for 10s. The compositions prepared in examples 1 to 3 and comparative examples 1 to 3 of the invention were applied to the mosquito bite sites of the volunteers, and the skin itch fading time and the soothing degree of 6 groups of volunteers were recorded, wherein the full score of the pain and itch soothing degree was 10, 0 score indicated no soothing sensation, and 10 scores indicated very good soothing sensation.
The cooling and soothing sensory test results are shown in table 1:
as can be seen from the above table, the cooling duration of the cooling and itching relieving compositions prepared in examples 1 to 3 of the present invention can be 63min or more, and at the 30 th min after the application of the composition, the evaluation of the cooling is 5, the average time for the skin itch to subside is 5.7min, and the average pain and itch relief degree is 8 min. Experiments show that the invention adopts scientific proportion, ethanol solution with certain mass concentration is effectively combined with taraxasterol, phillyrin, gardenia extract, aloe extract, asparagine, borneol and polypropylene glycol-28-butyl ether-35, and a specific preparation process is combined, so that the obtained mild, cool and itching relieving composition not only prolongs the feeling time of skin on cooling, but also can effectively relieve the discomfort of mosquito bite and achieve the effect of quickly relieving itching, and can avoid the strong irritation effect brought by excessive cooling agents, obviously relieve the pain feeling, even the burning feeling, caused by the cooling feeling to the skin, and achieve the effect of mildly and quickly relieving itching.
As can be seen from Table 1, in comparative examples 1 and 2, at the 30 th min after the application of the composition, the evaluation scores of the cooling sensation are respectively 3 and 4, and the duration of the cooling sensation lasts for 77min on average, but the pain and itch relief degrees of comparative examples 1 and 2 are respectively 3.4 and 2.7, the skin itch resolution time is respectively 10 and 9min, the cooling sensation of comparative example 1 is weaker, the cooling sensation of comparative example 2 is stronger, and the pain and itch relief degrees of comparative examples 1-2 are lower, which indicates that the absence of aloe extract or taraxasterol reduces the efficacy of relieving itching, preferably the use effect of the product is reduced; comparative example 3, although the itch fading time and the pain itch relieving degree were not much different from those of examples 1 to 3, the cool feeling duration time of comparative example 3 was 36min from the cool feeling duration time, and was lower than those of examples 1 to 3 and comparative examples 1 to 2 in both the cool feeling score at 30min, 3, indicating that the cool feeling duration time was greatly shortened if the ice pieces in the present invention were removed.
2. Test for relieving itching
The itching relieving experimental method comprises the following steps: 80 healthy rats are divided into 4 groups according to the random grouping principle, physiological saline is used as a reagent of a blank group in the experiment, and the commercially available Longhu cooling oil (national standard Z31020047, product specification: 3 g) is applied to a control group. Rats of experimental group 1 were applied with the cooling and itching relieving composition of the present invention, which was just prepared in example 3, and mice of experimental group 2 were applied with the mild cooling and itching relieving composition of the present invention, which was stored at 50 ℃ for 3 months. The right hind instep of the mouse was dehaired, and the shaved part of the instep was scratched with sandpaper at 1cm2 to the extent that the epidermis was damaged, the dermis was not damaged, and the skin was slightly oozed. After waiting for one day, the corresponding products are respectively smeared on the instep wound of the rat, wherein the smearing amount is 0.2 mL/mouse each time, 2 times a day and 3 days continuously. After the last smearing for 30min, 0.01% histamine phosphate 0.05mL is dripped on the wound surface of each rat, the concentration of the histamine phosphate is sequentially increased according to the concentration of 0.01%, 0.02%, 0.03% and 0.04% every 3min, the concentration is increased by 0.01% every time, the dripping amount is 0.05mL every time, and whether the rat licks the back foot after returning is observed. When the rats were found to lick their right hind paw after head return, the total amount of histamine phosphate given at this time was the scratchiness threshold. The analysis of differences between groups was performed in comparison to the blank control group. The test results are shown in table 2:
remarking: * Denotes P <0.01 compared to the blank group.
The above experimental results show that the mild cooling and itching relieving compositions of experimental group 1 and experimental group 2 both have significant itching relieving effects.
In conclusion, the scientifically prepared cooling and itching relieving composition not only reduces the strong irritation of the cooling feeling, but also preferably prolongs the cooling feeling of the skin, effectively relieves the pain feeling of the skin to burning heat and pruritus, has the effect of quickly relieving itching and fully improves the stability of the pesticide effect of the composition.
Furthermore, it should be understood that although the present description refers to embodiments, not every embodiment may contain only a single embodiment, and such description is for clarity only, and those skilled in the art should integrate the description, and the embodiments may be combined as appropriate to form other embodiments understood by those skilled in the art.
Claims (8)
1. A cooling and itching relieving composition is characterized in that: comprises the following raw materials in percentage by weight: 20 to 35 percent of ethanol solution, 0.1 to 1 percent of taraxasterol, 0.1 to 1 percent of forsythol, 0.1 to 0.5 percent of asparagine, 0.1 to 0.5 percent of aloe extract, 0.1 to 1 percent of gardenia extract, 0.1 to 0.5 percent of borneol, 0.1 to 0.3 percent of polypropylene glycol-28 butyl ether-35, 0.1 to 0.3 percent of triethanolamine or tromethamine and the balance of water.
2. A cooling and itching relieving composition according to claim 1, wherein: comprises the following raw materials in percentage by weight: 20% of ethanol solution, 0.2% of taraxasterol, 0.3% of forsythol, 0.2% of asparagine, 0.1% of aloe extract, 0.1% of gardenia extract, 0.2% of borneol, 0.1% of polypropylene glycol-28 butyl ether-35, 0.1% of triethanolamine or tromethamine and the balance of water.
3. A cooling and itching relieving composition according to claim 1, wherein: the ethanol solution has a mass concentration of 40-50%.
4. A method of preparing a cooling and itching relieving composition as claimed in claim 1, wherein: the method comprises the following steps:
(1) Adding water into taraxasterol, forsythol, gardenia extract and aloe extract, heating to 43-55 ℃, stirring, adding ethanol solution, performing ultrasonic oscillation in water bath, and standing for 10-20 min to obtain a mixture A;
(2) Adding water into asparagine, borneol and polypropylene glycol-28-butyl ether-35, heating and stirring to 70-75 ℃, cooling, adding triethanolamine or tromethamine to adjust the pH value to obtain a mixture B;
(3) And taking the mixture B, and adding the mixture A under the condition of continuously stirring at 35-50 r/min to obtain the cooling and itching relieving composition.
5. A method of preparing a cooling and itching relieving composition, as claimed in claim 4, wherein: in the step (1), the conditions of the ultrasonic oscillation of the water bath are that the oscillation frequency is 210-250 r/min, the oscillation time is 25-35 min, and the temperature of the water bath is 30-35 ℃.
6. A method for preparing a cooling and itching relieving composition as claimed in claim 4, wherein: in the step (2), the heating and stirring speed is 220-300 r/min; the temperature is reduced to 30-35 ℃ at a stirring speed of 30-50 r/min.
7. A method of preparing a cooling and itching relieving composition, as claimed in claim 4, wherein: the preparation method of the aloe extract comprises the following steps: cleaning appropriate amount of aloe, drying, peeling dried aloe, collecting aloe liquid, grinding the collected aloe liquid into juice, placing into a beaker, adding complex enzyme for enzymolysis, filtering by an oscillator after enzymolysis, performing reflux purification extraction after filtering, sterilizing at high temperature after qualified extraction to obtain extract, wherein the enzymolysis temperature is 39-45 ℃, the enzymolysis pH value is 4.1-5.0, and the enzymolysis time is 1.5-2.5h; the adding weight of the compound enzyme agent is 0.15-0.25% of the total weight of the aloe liquid, and the compound enzyme agent comprises the following enzymes in parts by weight: 3-5 parts of cellulase, 3-4 parts of carboxylase, 2-4 parts of glycosidase and 1.5-2.5 parts of pectinase.
8. A method for preparing a cooling and itching relieving composition as claimed in claim 4, wherein: the preparation method of the aloe extract comprises the following steps: cleaning appropriate amount of aloe, drying, peeling dried aloe, collecting aloe liquid, grinding the collected aloe liquid into juice, placing into a beaker, adding complex enzyme for enzymolysis, filtering by an oscillator after enzymolysis, performing reflux purification extraction after filtering, performing high-temperature sterilization after qualified extraction to obtain an extract, wherein the enzymolysis temperature is 40-42 ℃, the enzymolysis pH value is 4.5-5.0, and the enzymolysis time is 1.8-2.3h; the adding weight of the compound enzyme agent is 0.15-0.25% of the total weight of the aloe liquid, and the compound enzyme agent comprises the following enzymes in parts by weight: 4 parts of cellulase, 3 parts of carboxylase, 3 parts of glycosidase and 2.5 parts of pectinase.
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| CN202211375408.8A CN115737734A (en) | 2022-11-04 | 2022-11-04 | A composition with refreshing and antipruritic effects |
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Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102716304A (en) * | 2012-06-27 | 2012-10-10 | 赵海涛 | Chinese medicinal preparation for treating dermatosis and preparation method thereof |
| CN103142749A (en) * | 2011-12-06 | 2013-06-12 | 刘柏 | Anti-bacterial and anti-inflammatory cream |
| CN110559246A (en) * | 2019-11-06 | 2019-12-13 | 珠海市宝丽金化妆品有限公司 | Itching-dispelling and relieving ointment and preparation method thereof |
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- 2022-11-04 CN CN202211375408.8A patent/CN115737734A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103142749A (en) * | 2011-12-06 | 2013-06-12 | 刘柏 | Anti-bacterial and anti-inflammatory cream |
| CN102716304A (en) * | 2012-06-27 | 2012-10-10 | 赵海涛 | Chinese medicinal preparation for treating dermatosis and preparation method thereof |
| CN110559246A (en) * | 2019-11-06 | 2019-12-13 | 珠海市宝丽金化妆品有限公司 | Itching-dispelling and relieving ointment and preparation method thereof |
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