CN1157137A

CN1157137A - Cream for curing eczema

Info

Publication number: CN1157137A
Application number: CN 96115108
Authority: CN
Inventors: 牟广志; 石世光
Original assignee: Individual
Current assignee: Individual
Priority date: 1996-02-14
Filing date: 1996-02-14
Publication date: 1997-08-20
Anticipated expiration: 2016-02-14
Also published as: CN1062132C

Abstract

The present invention relates to a cream preparation for external use to cure eczema and impetigo herpetifomis, etc. Its composition is composed of 250-500 portions of chloromycetin, 100-200 portions of moroxydine, 400-1000 portions of metronidazole, 10-20 portions of chlortrimeton, 5-10 portions of dexamethasone, 5-100 portions of vitamin B6, 0.5-1.0 portion of vitamin B12, 20000 portions of purified water and 10000 portions of emulsifying agent. Said invented cream preparation has no toxic side effect, and is safe and obvious in therapeutic effect, and its total effective rate is 99.32%.

Description

Cream for curing eczema

The invention belongs to the dermopathic medicine for external use of treatment, particularly a kind of treatment eczema, the dermopathic external-application cream of impetigo.

Eczema is a kind of allergy scytitis, by reasons such as damp and hot, dry, daylight, allergy, make the oxidation of skin sebum, generation is harmful to the material of skin, and the cell that perspiration and human body come off mixes formation skin dirt with extraneous dust, hinders the normal secretion of perspiration and sebum, easy breed bacteria, cosmetics in addition, the contained chemical element of the underwear of dress ornament staple fibre causes dermatosis, causes that the skin surface pathological changes is wet examines.Skin shallow-layer suppurative dermatosis by pathogenic bacterium staphylococcus aureus and streptococcus initiation.At present the skin chronic eczema is adopted " PIYANPING " ointment of efficient antiallergic and antipruritic agent preparation, has antiinflammatory, antipruritic, antianaphylactic curative effect, its cure rate 63.8%, obvious effective rate 86.6%, total effective rate 99%, owing to include hormone, dependency occurs after using this unguentum, influence curative effect, and impetigo is not had therapeutic effect.

The object of the present invention is to provide a kind of have antipruritic, convergence, antibiotic, the external curing skin eczema of antiinflammatory, the cream of impetigo.

Solution of the present invention is pathogeny understanding and the Therapeutic Principle to the pathology of skin class disease eczema and impetigo, pathological changes, from western proprietary, filter out antibiotics and antiviral drugs chloromycetin, moroxydine, metronidazole, antihistaminic class medicine chlorphenamine, its medicine dexamethasone of hormone, the vitamin medicaments B of tool allergy and antiinflammation ₆, B ₁₂Skin-nourishing is provided, enhances metabolism, have that sterilization, antiinflammatory, secretion inhibitor, minimizing are oozed out, a convergence, antiseptical synergism.

The present invention treats the external-application cream of skin eczema, impetigo and prepares (weight portion) by following component

Chloromycetin 250-500 part, moroxydine 100-200 part, metronidazole 400-1,000 part, chlorphenamine 10-20 part, dexamethasone 5-10 part, vitamin B ₆50-100 part, vitamin B ₁₂0.5-1.0 part, 20,000 parts of Purified Waters, 10,000 parts of emulsifying agents.

Above-mentioned each component is made the preparation method of external skin cream for curing eczema of the present invention, emulsifying agent is mixed in right amount, be heated to 90 ℃ after, stir the molten even cooling that is mixed, select suitable mortar for use, with Western medicine Metronidazole Tablet, vitamin B ₆Grind into 120 order powderies, add in the time of 58 ℃, continuous stirring adds chloromycetin, moroxydine, chlorphenamine, dexamethasone, Purified Water cooling then successively and is modulated into the emulsus cream.

Following examples mode specifies the present invention.

The method for making of cream for curing eczema, in rustless steel or acid-proof enamel pot, oil phase emulsifier is heated to 90 ℃ by the common 10g of anti-acid esters 5g of monoester and sorbitan fatty acid ester 5g after mixing, in the disinfectant mortar with Western medicine Metronidazole Tablet 400mg, vitamin B ₆It is 120 order powderies that 50mg grinds, and adds continuous stirring when waiting to expect temperature drop to 58 ℃, adds chloromycetin 250mg, moroxydine 100mg, chlorphenamine 10mg, dexamethasone 5mg, vitamin B then successively ₁₂0.5mg, Purified Water 2ml cooling reduces to 30-40 ℃ to be modulated into the barrelling of emulsus cream is finished product.

Embodiment 2, in rustless steel or acid-proof enamel pot with oil phase emulsifier fatty acid monoglyceride 5g and sorbitan fatty acid ester 5g mixing after 10g is heated to 90 ℃ altogether, in the disinfectant mortar with Western medicine Metronidazole Tablet 1,000mg, vitamin B ₆It is 120 order powderies that 100mg grinds, and adds when waiting to expect temperature drop to 58 ℃, and continuous stirring adds chloromycetin 500mg, moroxydine 200mg, chlorphenamine 20mg, dexamethasone 10mg, vitamin B then successively ₁₂1mg, Purified Water 2ml cooling is reduced to 30-40 ℃, and to be modulated into the barrelling of emulsus cream be finished product.

Abscess pathogenic bacteria and acne bacillus can be directly killed in chloromycetin of western medicine external in the cream for curing eczema, metronidazole has significant curative effect to mucocutaneous disease, moroxydine in eczema and the impetigo cause of disease element because of antibacterial and virus mixed infection, has the collaborative effect that heightens the effect of a treatment, chlorphenamine has antihistaminic, antiallergic, reduce the effect of oozing out, dexamethasone has antiinflammatory, antiallergic, antiviral, raise immunity and improves tissue metabolism's function, vitamin B ₆, B ₁₂But the activity of enhancing body epidermis cell is improved the metabolic process of skin, mucosa, and the tissue of inhibition is arranged by effect.

Use " cream for curing eczema " treatment eczema and impetigo 110 examples, through the clinical observation test, male's 42 examples, women's 68 examples make that the maximum is 36 years old year, and reckling is for coming into being back 17 days, and is in the majority with 2 months to 7 years old persons.Eczema 79 examples wherein, the course of disease is the longest 14 days, and is the shortest 2 days.Diseased region, women's head-ornaments portion 84 examples, cervical region 17 examples, other position 9 routine impetigo 31 examples.The course of disease is the longest 7 days, and is the shortest 2 days.

" cream for curing eczema " treatment eczema and impetigo 110 routine efficacy analysis see Table.

Disease name	The example number	Cure routine number	??％	Invalid	??％	Total effective routine number	??％
Disease name	The example number	Cure routine number	??％	Invalid	??％	Total effective routine number	??％	Eczema	??79	????78	??98.72	??1	??1.28	????78	??98.72
Impetigo	??31	????31	??100			????100	??100	Eczema	??79	????78	??98.72	??1	??1.28	????78	??98.72

Model case:

Eczema group: example 1: infant Liu *, the man, 11 years old, the student, bilateral ear-lobe portion flowing water is grabbed the back voluntarily because of ear's pruritus before the pruritus first quarter moon first quarter moon and is played " little red pimple ", and it is invalid that personal " skin is scorching clean " ointment is coated with outward, nearly week diabrosis, flowing water and seeking medical advice.

Check finding: little erythema and crowfoot cracks appear in infant bilateral ear-lobe portion, and the centre is slightly rotten to the corn, a little transudate, and visible on every side small rice grain size pimple is twined, and boundary is unclear, and external auditory meatus is normal, not enlargement of peripheral lymph node.Diagnosis: bilateral eczema of ear lobe.

The treatment process: after local skin lesion cleaned, outer be coated with " cream for curing eczema " in dry voluntarily back exposed every day three times.Check after two days: readme is not itched, not flowing water.Toposcopy: rotten to the corn face disappears, and is dry, the part decrustation, and pimple disappears on every side.The usefulness that continues " cream for curing eczema " twice-daily is coated with outward, and check is healed after four days.

Example 2: the infant model * *, the woman, 7 months, toposcopy in three days that measles " play " in buccal surface portion " rubescent ": forehead, big small set of the visible small rice grain in two sided buccal or lamellar pimple, part desquamation, nothing are oozed out.Infant does not have heating, and other positions do not have pimple and vesicle changes diagnosis: infantile eczema.The treatment process: the facial cleaning, dry voluntarily back is outer to be coated with " cream for curing eczema " twice-daily, further consultation after two days, local erythema disappears, recovery from illness.

Example 3: patient king *, the woman, 28 years old, the grade teacher, facial wiping " cosmetic cream " back bright itching occur and sought medical advice in three days.Once used " cosmetic cream " afterwards conscious facial uncomfortable feeling of the eye with burning itch before three days, and day by day increased the weight of to examine.The oiliness dough cover often is coated with usefulness " friendship " friend impunity usually.Toposcopy: bilateral buccal, forehead, following chin portion present patch shape erythema pimple, and boundary is unclear, the part desquamation, and nothing is oozed out.Diagnosis: cosmetic dermatitis (eczema sexually revises) treatment process: stop using " cosmetic cream ", the part is outer to be coated with " cream for curing eczema " twice-daily, adds with each one bag of oral fangfeng tongsheng pill twice-daily (6 gram).Check after three days: itch after the medication and end, no desquamation, local erythema pimple disappears, and skin gloss is normal, recovery from illness.

Impetigo group: example 1: infant opens *, the woman, 3 years old, the back left side bicker of 5 days one all causes " flu " of left side bicker " blister " diabrosis flowing water and down chin play vesicle, blister diabrosis before 5 days, flowing water are not felt any better from being coated with gentian voiet, order stream yellow fluid and seeking medical advice.

Toposcopy: left side bicker and the following chin portion rotten to the corn face of Semen Viciae fabae size of as seen trooping, the part incrustation has a little secretions.Diagnosis: impetigo.The treatment process: dry voluntarily after local hydrogen peroxide cleans, be coated with " cream for curing eczema " twice-daily outward, expose.Further consultation after three days, local rotten to the corn face is dry, no pus crusts and oozing out, skin lesion is normal again, fully recovers.

Example 2: infant Liu * *, the man, 7 years old, left buccal surface cheek " blister " was examined in 5 days.Toposcopy: the big crust of the infant left side cheek visible Semen Viciae fabae of gill lappet, rotten to the corn face, talk about secretions less, boundary clear, not enlargement of bilateral parotid gland diagnosis: pus kitchen skin ulcer.The treatment process: dry voluntarily after hydrogen peroxide cleans, be coated with " cream for curing eczema " twice-daily outward, further consultation after three days, local rotten to the corn face disappears, and no secretions, skin lesion are normal again, recovery from illness.

Example 3: infant Zhao * *, woman, 13 years old, student.Because of " flu " after 5 days the left side bicker play that " blister " is upheld a mouth pain.Toposcopy: the left side bicker is collection bunch shape soybean grain size three place's pus crusts, a little secretions.Diagnosis: impetigo, treatment process: dry voluntarily after hydrogen peroxide cleans, be coated with " cream for curing eczema " outward days for three times, add with two day of Metronidazole Tablet three times oral.Further consultation after three days, pus crusts comes off, and no secretions, skin lesion are normal again, dehisce freely recovery from illness

Use eczema treatment skin eczema and impetigo, have nutrition and drug action concurrently, curative effect is obvious, total effective rate is 99.32%, has no side effect, and medication is easy, stable effective ingredients, effect relaxes, and skin easily absorbs, and does not have irritated reaction, improve the tissue circulation, has nutrition, safety, antiinflammatory, antipruritic, anticorrosion, astringent synergism.

Claims

1, a kind of medicine for external use for the treatment of eczema is characterized in that it is the cream of being made by the following weight proportion raw material:

Chloromycetin 250-500 part, moroxydine 100-200 part, metronidazole 400-1,000 part, chlorphenamine 10-20 part, dexamethasone 5-10 part, vitamin B ₆50-100 part, vitamin B ₁₂0.5-1.0 part, 10,000 parts of emulsifying agents, 20,000 parts of Purified Waters