CN106937988A - A kind of nti-freckle menstruation regulating Chinese medicine composition and preparation method thereof - Google Patents

A kind of nti-freckle menstruation regulating Chinese medicine composition and preparation method thereof Download PDF

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CN106937988A
CN106937988A CN201710244738.6A CN201710244738A CN106937988A CN 106937988 A CN106937988 A CN 106937988A CN 201710244738 A CN201710244738 A CN 201710244738A CN 106937988 A CN106937988 A CN 106937988A
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parts
freckle
nti
powder
blood
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CN106937988B (en
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赵新杰
夏华玲
丁震
孙实
刘运涛
武爱玲
江海肖
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HENAN LUOZHENG PHARMACEUTICAL FACTORY
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HENAN LUOZHENG PHARMACEUTICAL FACTORY
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/88Liliopsida (monocotyledons)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/36Skin; Hair; Nails; Sebaceous glands; Cerumen; Epidermis; Epithelial cells; Keratinocytes; Langerhans cells; Ectodermal cells
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/56Materials from animals other than mammals
    • A61K35/618Molluscs, e.g. fresh-water molluscs, oysters, clams, squids, octopus, cuttlefish, snails or slugs
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/06Fungi, e.g. yeasts
    • A61K36/07Basidiomycota, e.g. Cryptococcus
    • A61K36/076Poria
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/23Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A61K36/232Angelica
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/25Araliaceae (Ginseng family), e.g. ivy, aralia, schefflera or tetrapanax
    • A61K36/258Panax (ginseng)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/81Solanaceae (Potato family), e.g. tobacco, nightshade, tomato, belladonna, capsicum or jimsonweed
    • A61K36/815Lycium (desert-thorn)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/14Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/20Pills, tablets, discs, rods
    • A61K9/2004Excipients; Inactive ingredients
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/48Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841Filling excipients; Inactive ingredients

Abstract

The present invention discloses a kind of nti-freckle menstruation regulating Chinese medicine composition, is made up of according to parts by weight following bulk drug:1~5 part of 2~10 parts of American Ginseng, 2~10 parts of donkey-hide gelatin, 2~10 parts of Radix Angelicae Sinensis, 2~10 parts of pseudo-ginseng, 1~5 part of west safflower, 2~10 parts of Poria cocos, 2~10 parts of the fruit of Chinese wolfberry, 0.5~2 part of pearl powder and the root of Dahurain angelica.Described nti-freckle menstruation regulating Chinese medicine composition can be prepared into the various formulations such as powder, pill, capsule.The composition of the present invention has effects that benefiting qi and nourishing blood, promoting blood circulation for regulating menstruation, beautifying face and moistering lotion, for the color spot caused by deficient qi and blood, stagnation of blood stasis, irregular menstruation etc. have good effect, it is uneasy to recur, convenient to take, have no toxic side effect the characteristics of, to the spiritlessness and weakness caused by deficient qi and blood, stagnation of blood stasis, have a dizzy spell, the disease such as sallow complexion and dysmenorrhoea, there are good therapeutic effect, increase clinical application selectivity.

Description

A kind of nti-freckle menstruation regulating Chinese medicine composition and preparation method thereof
Technical field
The invention belongs to field of traditional Chinese, and in particular to a kind of nti-freckle menstruation regulating Chinese medicine composition and preparation method thereof.
Background technology
Chloasma is a kind of common acquired hyperpigmentation dermatoses, category traditional Chinese medicine " chloasma hepaticum ", " blackish facial patch ", " butterfly The categories such as butterfly spot ", illness rate is higher in general population, is apt to occur in young and middle-aged women, and Female in child bearing period is more, is easily to examine refractory One of dermatoses.Modern research suggests that, chloasma pathogenesis is complicated, caused by multifactor functioning, inherent cause, essence Refreshing factor, drug factors (mainly contraceptive and antiepileptic etc.), disease factor, Exposure to Sunlight, gestation, bad habits and customs and Cosmetics improper use etc. can turn into this sick inducement, and endocrine disturbance, skin microbial state treatment and radical damage are them Main pathogenesis.Chloasma is in close relations with irregular menstruation, and chloasma is clinically very common with irregular menstruation person.Chloasma Capacitive, influence patient's appearance and physical and mental health are damaged with significant, it is hidden in the heart as Junior Lady as irregular menstruation Bitterly.
Current western medical treatment chloasma is without specific process, and external application depigmentaton or depigmenting preparations are melanin in treatment epidermis Increase most efficient method.Conventional treatment method includes local application(Quinhydrones, azelaic acid, Tretinoin etc.), laser therapy etc., But it can only control, it is impossible to which chloasma is eradicated, easily repeatedly, side effect still often occur, late result is difficult to make us full Meaning.
Chinese traditional treatment chloasma has long history, with certain advantage.The traditional Chinese medical science thinks that human body is one unified Overall, in vitro with internal close relation, internal lesion can be showed by outside syndrome, just so-called " have all interior persons, must shape it is all Outside ".The generation of chloasma is also that so body feelings will is unsuccessful, native not normal, the kidney water virtual loss of spleen, qi deficiency to blood stasis, causes spleen to lose strong Fortune, failure of skin and muscle to be nourished, the accumulation of the pathological product such as phlegm, the stasis of blood, wet, form chloasma.Meanwhile, deficient qi and blood, stagnation of blood stasis can also cause Delayed menstrual cycle and hypomenorrhia." no stasis of blood not spotting, there is spot to have the stasis of blood ", thus chloasma and irregular menstruation Ying Congxu, from stasis of blood opinion Control.Current external treatment of traditional Chinese medicine is often using the external application of Chinese medicine or face mask of traditional Chinese medicine treatment chloasma, but some are irritant, and some can be caused Quick, because not nursed one's health from body interior, therefore long-term effect is not good enough, while irregular menstruation can not be taken into account;Internal therapy often uses decoction Conditioning, the two can be taken into account simultaneously, but inconvenient for use, there is certain limitation.Therefore it provides one kind can treat simultaneously chloasma and Irregular menstruation and Chinese medicine preparation easy to use is very necessary.
The content of the invention
It is an object of the invention to provide a kind of nti-freckle menstruation regulating Chinese medicine composition and preparation method thereof, said composition has tonifying Qi Blood-nourishing, promoting blood circulation for regulating menstruation, effect of beautifying face and moistering lotion, have for the color spot caused by deficient qi and blood, stagnation of blood stasis, irregular menstruation etc. and treat Imitate, it is uneasy to recur, convenient to take, the characteristics of have no toxic side effect, to the spiritlessness and weakness caused by deficient qi and blood, stagnation of blood stasis, head The dizzy disease such as dizzy, sallow complexion and dysmenorrhoea, there is good therapeutic effect, increase clinical application selectivity.
The technical solution adopted in the present invention is:A kind of nti-freckle menstruation regulating Chinese medicine composition, according to parts by weight by following original Expect medicine composition:2~10 parts of American Ginseng, 2~10 parts of donkey-hide gelatin, 2~10 parts of Radix Angelicae Sinensis, 2~10 parts of pseudo-ginseng, 1~5 part of west safflower, Poria cocos 2 1~5 part of~10 parts, 2~10 parts of the fruit of Chinese wolfberry, 0.5~2 part of pearl powder and the root of Dahurain angelica.
As a kind of further optimization of nti-freckle menstruation regulating Chinese medicine composition of the invention, according to parts by weight by following bulk drug Composition:5 parts of American Ginseng, 5 parts of donkey-hide gelatin, 5 parts of Radix Angelicae Sinensis, 5 parts of pseudo-ginseng, 3 parts of west safflower, 5 parts of Poria cocos, 5 parts of the fruit of Chinese wolfberry, 1 part of pearl powder With 2 parts of the root of Dahurain angelica.
Described nti-freckle menstruation regulating Chinese medicine composition can be prepared into the various formulations such as powder, pill, capsule.
The preparation method of described nti-freckle menstruation regulating traditional Chinese powder medicine, weighs each bulk drug, except pearl powder by above-mentioned formula rate Outside, remaining eight taste bulk drug is ground into fine powder, adds pearl powder, mixes, obtains powder.
The preparation method of described nti-freckle menstruation regulating medicine pill, weighs each bulk drug, except pearl powder by above-mentioned formula rate Outside, remaining eight taste bulk drug is ground into fine powder, adds pearl powder, mixes, with water pill, dries, obtains pill.
Described nti-freckle menstruation regulating Chinese medicine capsules, each bulk drug is weighed by above-mentioned formula rate, and in addition to pearl powder, remaining eight Taste bulk drug is ground into fine powder, adds pearl powder, mixes, and loads capsule, obtains capsule.
Compared with prior art, the present invention at least tool has the advantage that and beneficial effect:
In drug component of the present invention, American Ginseng, sweet, slight bitter is cool, the thoughts of returning home, lung, kidney channel, boosting qi and nourishing yin, relieves inflammation or internal heat and promotes the production of body fluid;Donkey-hide gelatin, It is sweet, flat, return lung, liver and kidney channel, enriching yin of enriching blood.The two tonifying Qi again, one enriches blood again, the void filled blood, is altogether monarch drug in a prescription.Radix Angelicae Sinensis, taste Gan Erchong, therefore can specially enrich blood, its gas is light and pungent, therefore again can promoting circulation of blood, bowl spares has, has benefit in row, be the key medicine in blood, can mend Blood, and can invigorate blood circulation, it can both stimulate the menstrual flow, and can be active, especially suitable women is used, and is particularly suitable for irregular menstruation, dysmenorrhoea, deficiency of blood amenorrhoea Etc. disease, it is referred to as " gynaecology's panacea " by ancients;Pseudo-ginseng, sweet, slight bitter, temperature, Return liver, stomach, dissipate stasis of blood hemostasis, detumescence ding-tong is arrogated to oneself and controlled Metrorrhagia, incessant menorrhea, extravesated blood not under, have dual regulation;West safflower, sweet, flat, the thoughts of returning home, Liver Channel, promoting blood circulation and removing blood stasis, cool blood solution Poison,《Compendium of Materia Medica》Yan Qineng controls " worry and smoulder, be unhappy not dissipate ", therefore again can soothing liver-qi stagnation.Above three is ministerial drug altogether.Fu Siberian cocklebur, sweet, light, flat, the thoughts of returning home, lung, spleen, kidney channel, invigorating spleen to remove dampness controls phlegm originally, the wet turbid pathogenic factors of Fen Lishui;The fruit of Chinese wolfberry, sweet flat matter profit, returns Liver and kidney channel, flat filling liver kidney;Pearl powder, it is sweet, salty, tremble with fear, the thoughts of returning home, Liver Channel, freckle removing and whitening,《Compendium of Materia Medica》Yan Qineng " except face is dim ". Above three is adjutant altogether.The root of Dahurain angelica, pungent fragrant temperature dissipates, return lung, spleen, stomach,《Japan hanako materia medica》Yan Qineng " goes face Shao- defects scar ", on Wardrobe face, priming is up, is guiding drug, to make medicine.For color spot and irregular menstruation deficient qi and blood, the interpretation of the cause, onset and process of an illness of stagnation of blood stasis, entirely It is accurate that side suits the medicine to the illness, mild in medicine property and, oiliness not dry, liver,spleen,kidney is with controlling, and the qi and blood people having the same aspiration and interest, mutually collaboration are treated both principal and secondary aspect of disease, common to play Benefiting qi and nourishing blood, promoting blood circulation for regulating menstruation, effect of beautifying face and moistering lotion, have preferably to the color spot caused by deficient qi and blood, stagnation of blood stasis, irregular menstruation Curative effect, and it is uneasy to recur, convenient to take, have no toxic side effect, while to the spiritlessness and weakness caused by deficient qi and blood, stagnation of blood stasis, head The dizzy disease such as dizzy, sallow complexion and dysmenorrhoea, there is good therapeutic effect, increase clinical application selectivity.
Compared with traditional nti-freckle, menstruation regulating therapy and product, medicine of the present invention can nti-freckle, and can menstruation regulating, technique is simple, side Just patient carries, used, and is also a supplement well to current nti-freckle menstruation regulating product, with good application value.
Embodiment
A kind of nti-freckle menstruation regulating Chinese medicine composition, is made up of according to parts by weight following bulk drug:2~10 parts of American Ginseng, Ah 2~10 parts of glue, 2~10 parts of Radix Angelicae Sinensis, 2~10 parts of pseudo-ginseng, 1~5 part of west safflower, 2~10 parts of Poria cocos, 2~10 parts of the fruit of Chinese wolfberry, pearl 1~5 part of 0.5~2 part of powder and the root of Dahurain angelica.
Described nti-freckle menstruation regulating Chinese medicine composition can be prepared into the various formulations such as powder, pill, capsule.
The preparation method of described nti-freckle menstruation regulating traditional Chinese powder medicine, weighs each bulk drug, except pearl powder by above-mentioned formula rate Outside, remaining eight taste bulk drug is ground into fine powder, adds pearl powder, mixes, obtains powder.
The preparation method of described nti-freckle menstruation regulating medicine pill, weighs each bulk drug, except pearl powder by above-mentioned formula rate Outside, remaining eight taste bulk drug is ground into fine powder, adds pearl powder, mixes, with water pill, dries, obtains pill.
Described nti-freckle menstruation regulating Chinese medicine capsules, each bulk drug is weighed by above-mentioned formula rate, and in addition to pearl powder, remaining eight Taste bulk drug is ground into fine powder, adds pearl powder, mixes, and loads capsule, obtains capsule.To become apparent from present disclosure Understandable, below in conjunction with specific embodiment, the present invention will be described in detail.
Embodiment 1:
By weight, 2 parts of American Ginseng, 2 parts of donkey-hide gelatin, 2 parts of Radix Angelicae Sinensis, 2 parts of pseudo-ginseng, 1 part of west safflower, 2 parts of Poria cocos, 2 parts of the fruit of Chinese wolfberry, treasure are taken 0.5 part of pearl powder, 1 part of the root of Dahurain angelica, in addition to pearl powder, remaining eight taste bulk drug is ground into fine powder, adds pearl powder, mixes, obtains powder.
Embodiment 2:
By weight, 5 parts of American Ginseng, 5 parts of donkey-hide gelatin, 5 parts of Radix Angelicae Sinensis, 5 parts of pseudo-ginseng, 3 parts of west safflower, 5 parts of Poria cocos, 5 parts of the fruit of Chinese wolfberry, treasure are taken 1 part of pearl powder, 2 parts of the root of Dahurain angelica, in addition to pearl powder, remaining eight taste bulk drug is ground into fine powder, adds pearl powder, mixes, obtains powder.
Embodiment 3:
By weight, 10 parts of American Ginseng, 10 parts of donkey-hide gelatin, 10 parts of Radix Angelicae Sinensis, 10 parts of pseudo-ginseng, 5 parts of west safflower, 10 parts of Poria cocos, the fruit of Chinese wolfberry are taken 10 parts, 2 parts of pearl powder, 5 parts of the root of Dahurain angelica.In addition to pearl powder, remaining eight taste bulk drug is ground into fine powder, adds pearl powder, mixes, obtains Powder.
Embodiment 4:
By weight, 2 parts of American Ginseng, 2 parts of donkey-hide gelatin, 2 parts of Radix Angelicae Sinensis, 2 parts of pseudo-ginseng, 1 part of west safflower, 2 parts of Poria cocos, 2 parts of the fruit of Chinese wolfberry, treasure are taken 0.5 part of pearl powder, 1 part of the root of Dahurain angelica, in addition to pearl powder, remaining eight taste bulk drug is ground into fine powder, adds pearl powder, mixes, general with water Ball, dries, obtains pill.
Embodiment 5:
By weight, 5 parts of American Ginseng, 5 parts of donkey-hide gelatin, 5 parts of Radix Angelicae Sinensis, 5 parts of pseudo-ginseng, 3 parts of west safflower, 5 parts of Poria cocos, 5 parts of the fruit of Chinese wolfberry, treasure are taken 1 part of pearl powder, 2 parts of the root of Dahurain angelica, in addition to pearl powder, remaining eight taste bulk drug is ground into fine powder, adds pearl powder, mixes, with water pill, Dry, obtain pill.
Embodiment 6:
By weight, 10 parts of American Ginseng, 10 parts of donkey-hide gelatin, 10 parts of Radix Angelicae Sinensis, 10 parts of pseudo-ginseng, 5 parts of west safflower, 10 parts of Poria cocos, the fruit of Chinese wolfberry are taken 10 parts, 2 parts of pearl powder, 5 parts of the root of Dahurain angelica.In addition to pearl powder, remaining eight taste bulk drug is ground into fine powder, adds pearl powder, mixes, with Water pill, dries, obtains pill.
Embodiment 7:
By weight, 2 parts of American Ginseng, 2 parts of donkey-hide gelatin, 2 parts of Radix Angelicae Sinensis, 2 parts of pseudo-ginseng, 1 part of west safflower, 2 parts of Poria cocos, 2 parts of the fruit of Chinese wolfberry, treasure are taken 0.5 part of pearl powder, 1 part of the root of Dahurain angelica, in addition to pearl powder, remaining eight taste bulk drug is ground into fine powder, adds pearl powder, mixes, and loads glue Capsule, obtains capsule.
Embodiment 8:
By weight, 5 parts of American Ginseng, 5 parts of donkey-hide gelatin, 5 parts of Radix Angelicae Sinensis, 5 parts of pseudo-ginseng, 3 parts of west safflower, 5 parts of Poria cocos, 5 parts of the fruit of Chinese wolfberry, treasure are taken 1 part of pearl powder, 2 parts of the root of Dahurain angelica, in addition to pearl powder, remaining eight taste bulk drug is ground into fine powder, adds pearl powder, mixes, and loads capsule, Obtain capsule.
Embodiment 9:
By weight, 10 parts of American Ginseng, 10 parts of donkey-hide gelatin, 10 parts of Radix Angelicae Sinensis, 10 parts of pseudo-ginseng, 5 parts of west safflower, 10 parts of Poria cocos, the fruit of Chinese wolfberry are taken 10 parts, 2 parts of pearl powder, 5 parts of the root of Dahurain angelica.In addition to pearl powder, remaining eight taste bulk drug is ground into fine powder, adds pearl powder, mixes, dress Enter capsule, obtain capsule.
Above example is only for the present invention is further illustrated, and the scope of the present invention is not by illustrated embodiment Limitation.
The beneficial effect of medicine of the present invention is further illustrated below by way of test example.
1st, physical data
Observation chloasma is included altogether with irregular menstruation(Hypomenorrhia, delayed menstrual cycle)Case 72, treatment group 36, control group 36 Example.Two groups there was no significant difference in terms of age, the state of an illness, the course of disease and card type, with comparativity.
2nd, diagnostic criteria
Chloasma using Dermatology Professional Committee of CAIM pigment disease group work out " chloasma is faced Bed diagnosis and criterion of therapeutical effect "(Revised draft in 2003);Irregular menstruation(Hypomenorrhia, delayed menstrual cycle)Using《Chinese medical disease is diagnosed Criterion of therapeutical effect》Middle hypomenorrhia, the diagnostic criteria of delayed menstrual cycle.
3rd, case selection standard
Meet the diagnosis of chloasma doctor trained in Western medicine and irregular menstruation(Hypomenorrhia, delayed menstrual cycle)Tcm diagnosis, Chinese medical discrimination belongs to qi and blood The two empty or stagnant uterus of the stasis of blood;18~45 years old age.Exclude freckle, senile plaque expelling, Riehl melanose;The reproductive organs device such as fibroid Matter venereal disease becomes caused irregular menstruation;It is associated with the severe primary disease such as angiocarpy, liver, kidney and hemopoietic system;Gestation and the food in one's mouth Newborn phase women.
4th, treatment method
Treatment group:The medicine of the present invention of embodiment 8(Luo Zheng pharmaceutical factories of Henan Province provide, specification:0.4g/), one time 3, daily 3 It is secondary, orally.Control group:Nti-freckle menstruation-regulating capsules(Yang Ling Ke Sen biological medicines Co., Ltd, specification:0.3g/), 3, one Day 2 times, orally.Taken medicine since after clean period the 1st day, even served 2 months, effective above case follow-up 3 months.Experimental period Between disable all and trial drug effectiveness identical Chinese and western drugses.
5th, observation index
Color spot area, color, the menstrual cycle, through amount, the related syndrome of the traditional Chinese medical science and security.
6th, curative effect determinate standard
Chloasma criterion of therapeutical effect
Cure:Naked eyes regard color spot area regression > 90%, and color disappears substantially;It is effective:Naked eyes regard color spot area regression > 60%, face Color is substantially thin out;Effectively:Naked eyes regard color spot area regression > 30%, and color is thin out;It is invalid:Naked eyes regard color spot area regression < 30%, color change is not obvious.
Irregular menstruation criterion of therapeutical effect
Cure:Menstrual cycle, through amount recover normal, 3 menstrual cycles of being discontinued do not recur;It is effective:Menstrual cycle, through amount recover just Often, but it can not maintain 3 months;It is invalid:Menstrual cycle, through amount have no improvement.
7th, treatment results
In chloasma treatment group 36,7 are cured, effective 13, effective 13, invalid 3, cure rate is 19.4%, it is total effective Rate is 91.7%.In control group 36, healing 4, effective example 15, effective 11, invalid 7, cure rate is 11.1%, total effective Rate is 80.6%.Two groups are compared, and cure rate and total effective rate have significant difference(P< 0.05).
In irregular menstruation treatment group 36,19 are cured, effective 16, invalid 1, cure rate is 52.8%, and effective percentage is 97.2%.In control group 36, healing 11, effective example 19, invalid 6, cure rate is 30.6%, and effective percentage is 83.3%.Two groups Compare, cure rate and effective percentage have significant difference(P< 0.05).
Two groups do not occur adverse reaction, and two kinds of medicines are tired to deficient qi and blood and the related syndrome of stagnation of blood stasis such as god Power, have a dizzy spell, sallow complexion, dysmenorrhea etc. have improvement result.

Claims (5)

1. a kind of nti-freckle menstruation regulating Chinese medicine composition, it is characterised in that:It is made up of according to parts by weight following bulk drug:American Ginseng 2 ~10 parts, 2~10 parts of donkey-hide gelatin, 2~10 parts of Radix Angelicae Sinensis, 2~10 parts of pseudo-ginseng, 1~5 part of west safflower, 2~10 parts of Poria cocos, the fruit of Chinese wolfberry 2~ 1~5 part of 10 parts, 0.5~2 part of pearl powder and the root of Dahurain angelica.
2. a kind of nti-freckle menstruation regulating Chinese medicine composition according to claim 1, it is characterised in that:According to parts by weight by following Bulk drug is constituted:5 parts of American Ginseng, 5 parts of donkey-hide gelatin, 5 parts of Radix Angelicae Sinensis, 5 parts of pseudo-ginseng, 3 parts of west safflower, 5 parts of Poria cocos, 5 parts of the fruit of Chinese wolfberry, pearl 2 parts of 1 part of powder and the root of Dahurain angelica.
3. a kind of preparation method of nti-freckle menstruation regulating Chinese medicine composition according to claim 1 or 2, it is characterised in that:By upper State formula rate and weigh each bulk drug, in addition to pearl powder, remaining eight taste bulk drug is ground into fine powder, adds pearl powder, mix, Obtain powder.
4. a kind of preparation method of nti-freckle menstruation regulating Chinese medicine composition according to claim 1 or 2, it is characterised in that:By upper State formula rate and weigh each bulk drug, in addition to pearl powder, remaining eight taste bulk drug is ground into fine powder, adds pearl powder, mix, With water pill, dry, obtain pill.
5. a kind of preparation method of nti-freckle menstruation regulating Chinese medicine composition according to claim 1 or 2, it is characterised in that:By upper State formula rate and weigh each bulk drug, in addition to pearl powder, remaining eight taste bulk drug is ground into fine powder, adds pearl powder, mix, Load capsule, obtain capsule.
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Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108157702A (en) * 2018-02-02 2018-06-15 青海紫元生态科技开发有限公司 A kind of anti-aging, beautifying face and moistering lotion compound oral liquid and preparation method thereof
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CN113425784A (en) * 2021-07-12 2021-09-24 黔东南民族职业技术学院 Beautifying formula for removing chloasma

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CN108157702A (en) * 2018-02-02 2018-06-15 青海紫元生态科技开发有限公司 A kind of anti-aging, beautifying face and moistering lotion compound oral liquid and preparation method thereof
CN108354990A (en) * 2018-03-26 2018-08-03 成都中医药大学 A kind of pharmaceutical composition of freckle removing and whitening and preparation method thereof
CN108354990B (en) * 2018-03-26 2021-04-30 成都中医药大学 Freckle-removing and whitening pharmaceutical composition and preparation method thereof
CN113425784A (en) * 2021-07-12 2021-09-24 黔东南民族职业技术学院 Beautifying formula for removing chloasma

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