CN106390104A - Plaster for curing skin itch - Google Patents

Plaster for curing skin itch Download PDF

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Publication number
CN106390104A
CN106390104A CN201611020051.6A CN201611020051A CN106390104A CN 106390104 A CN106390104 A CN 106390104A CN 201611020051 A CN201611020051 A CN 201611020051A CN 106390104 A CN106390104 A CN 106390104A
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China
Prior art keywords
parts
plaster
skin pruritus
treatment
biotin
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CN201611020051.6A
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Chinese (zh)
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不公告发明人
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Zhengzhou Zhengxian Pharmaceutical Technology Co Ltd
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Zhengzhou Zhengxian Pharmaceutical Technology Co Ltd
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Priority to CN201611020051.6A priority Critical patent/CN106390104A/en
Publication of CN106390104A publication Critical patent/CN106390104A/en
Pending legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/55—Protease inhibitors
    • A61K38/57—Protease inhibitors from animals; from humans
    • A61K38/58—Protease inhibitors from animals; from humans from leeches, e.g. hirudin, eglin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/075—Ethers or acetals
    • A61K31/085—Ethers or acetals having an ether linkage to aromatic ring nuclear carbon
    • A61K31/09—Ethers or acetals having an ether linkage to aromatic ring nuclear carbon having two or more such linkages
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/14—Quaternary ammonium compounds, e.g. edrophonium, choline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4188—1,3-Diazoles condensed with other heterocyclic ring systems, e.g. biotin, sorbinil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4402—Non condensed pyridines; Hydrogenated derivatives thereof only substituted in position 2, e.g. pheniramine, bisacodyl
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/455—Nicotinic acids, e.g. niacin; Derivatives thereof, e.g. esters, amides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • A61K31/573—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/886—Aloeaceae (Aloe family), e.g. aloe vera
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Engineering & Computer Science (AREA)
  • Botany (AREA)
  • Biotechnology (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Medical Informatics (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Dermatology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)

Abstract

The invention discloses a plaster for curing skin itch, wherein the plaster for curing skin itch comprises the following main materials in parts by weight: 8-12 parts of hirudin, 11-14 parts of biotin, 4-8 parts of nicotinamide, 5-10 parts of solanum tuberdsm anthocyanin, 12-17 parts of aloe gel, 29-34 parts of dexamethasone acetate, 15-30 parts of damiphene, 11-17 parts of diphenhydramine, 18-22 parts of lyonia resinol, and 10-17 parts of chlortrimeton. The medicines have an effect of inhibiting endogenous histamine, and also have an antagonistic activity on exogenous histamine, so that the effect of relieving itching of skins of the whole body is exerted by inhibiting the release of the histamine, and the plaster can be used to cure skin itch diseases like dermatitis, eczema, urticarial.

Description

A kind of plaster treating skin pruritus
Technical field
The present invention relates to a kind of pharmaceutical technology field, specifically a kind of plaster treating skin pruritus.
Background technology
Pruritus (pruritus) are a kind of conscious prurituss and the dermatosiss of clinically no primary lesion, are clinically common One of dermatosiss, it is characterized by based on prurituss, and no primary lesion.Locality and general two clinically can be divided into Kind.Locality pruritus are common in anus, pudendum or extremity etc., and local is only felt prurituss, had no erythra, and skin with the passing of time can be caused to increase Thickness, eczema sample changes.Anal canal and perianal obstinate pruritus are the cardinal symptoms of primary disease, from the beginning of when be generally limited to perianal Skin pruritus, mostly paroxysmal, the degree weight of prurituss differs, and does not such as heal for a long time, the spread to scrotum having or labia, especially Be before and after perineal position between seam prurituss more very, night is more notable, sometimes as worm climbs, ant walks；Sometimes as mosquito bite, baking, make one It is difficult to fall asleep, feel restless it is impossible to restrain oneself.General pruritus systemic all has the sensation itched everywhere, but is not that whole body is same When itch, often move on to another place by one.The degree itched is not quite similar, although someone thinks that skin is itched, but still permissible Stand, some patients think that whole body is very itched, need to ferrum brush brush skin or hot water laundering, until dermatorrhagia and feels pain and During causalgia, feel of itching just temporarily mitigates.Often itch again with night, patient has a sleepless night because itching or can not be sleeping.Due to violent prurituss, Constantly scratch, scratching of scratch, blood crustss or strip can occur, sometimes have the change of eczema sample, lichenification or pigmentation. The skin scratched also easily infects and furuncle and phyma or folliculitises occurs.Locality or the treatment of general pruritus, clinically also have Many Therapeutic Method, by all kinds of Chinese and western drugses or external use anti pruritic agent are administered orally, all can make prurituss alleviate and be cured.But wherein The pruritus patient that there are about 30% about is intractable pruritus.Although using medicine but not recovering for a long time or recurrent exerbation, treatment High cost, using method is complicated.
Content of the invention
It is an object of the invention to provide a kind of plaster treating skin pruritus, to solve proposition in above-mentioned background technology Problem.
For achieving the above object, the present invention provides following technical scheme：
A kind of plaster treating skin pruritus, the primary raw material according to weight portion is：Hirudin 8-12 part, biotin 11- 14 parts, nicotiamide 4-8 part, purple sweet potato anthocyanin 5-10 part, Aloe glue 12-17 part, dexamethasone acetate 29-34 part, oradol 15- 30 parts, diphenhydramine 11-17 part, Vaccinium bracteatum Thunb. wood gum phenol 18-22 part, chlorphenamine 10-17 part.
As the further scheme of the present invention：The plaster of described treatment skin pruritus, the primary raw material according to weight portion is： Hirudin 9-11 part, biotin 12-13 part, nicotiamide 5-7 part, purple sweet potato anthocyanin 6-8 part, Aloe glue 13-16 part, acetic acid ground plug The loose 30-32 part of rice, oradol 18-24 part, diphenhydramine 12-16 part, Vaccinium bracteatum Thunb. wood gum phenol 20-21 part, chlorphenamine 13-15 part.
As the further scheme of the present invention：The plaster of described treatment skin pruritus, the primary raw material according to weight portion is： 0 part of HV1,13 parts of biotin, 6 parts of nicotiamide, 7 parts of purple sweet potato anthocyanin, 15 parts of Aloe glue, 31 parts of dexamethasone acetate, Du Fragrant 21 parts of rice, 14 parts of diphenhydramine, 21 parts of Vaccinium bracteatum Thunb. wood gum phenol, 14 parts of chlorphenamine.
A kind of preparation method of the plaster treating skin pruritus, concretely comprises the following steps：
First, by hirudin, biotin, nicotiamide, purple sweet potato anthocyanin, Aloe glue, dexamethasone acetate, oradol, benzene Extra large Lamine, Vaccinium bracteatum Thunb. wood gum phenol, chlorphenamine mix, and constantly add water stirring, and mixing speed controls in 150-180r/min, stirring knot Shu Hou, evaporation and concentration at 40-60 DEG C, until the density of concentrate reaches 1.12-1.13g/cm3, load in ointment tube, obtain final product The plaster for the treatment of skin pruritus.
As the further scheme of the present invention：In concrete steps, mixing speed controls in 170r/min.
As the further scheme of the present invention：In concrete steps at 50 DEG C evaporation and concentration.
Compared with prior art, the invention has the beneficial effects as follows：
The medicine of the present invention is not only inhibited to endogenous histamine, and exogenous histamine also has antagonism to live Property, thus playing, by suppressing the release of histamine, the pharmacological action alleviating whole skin prurituss, can be used for dermatitis, eczema, nettle The treatment of the skin pruritus disease such as measles.
Specific embodiment
Below in conjunction with the embodiment of the present invention, the technical scheme in the embodiment of the present invention is clearly and completely described, Obviously, described embodiment is only a part of embodiment of the present invention, rather than whole embodiments.Based in the present invention Embodiment, the every other embodiment that those of ordinary skill in the art are obtained under the premise of not making creative work, all Belong to the scope of protection of the invention.
Embodiment 1
A kind of plaster treating skin pruritus, the primary raw material according to weight portion is：8 parts of hirudin, 11 parts of biotin, cigarette 4 parts of amide, 5 parts of purple sweet potato anthocyanin, 12 parts of Aloe glue, 29 parts of dexamethasone acetate, 15 parts of oradol, 11 parts of diphenhydramine, south 18 parts of candelilla Syringaresinol, 10 parts of chlorphenamine.
A kind of preparation method of the plaster treating skin pruritus, concretely comprises the following steps：
First, by hirudin, biotin, nicotiamide, purple sweet potato anthocyanin, Aloe glue, dexamethasone acetate, oradol, benzene Extra large Lamine, Vaccinium bracteatum Thunb. wood gum phenol, chlorphenamine mix, and constantly add water stirring, and mixing speed controls in 150r/min, and stirring terminates Afterwards, evaporation and concentration at 40 DEG C, until the density of concentrate reaches 1.12-1.13g/cm3, load in ointment tube, obtain final product treatment The plaster of skin pruritus.
Embodiment 2
A kind of plaster treating skin pruritus, the primary raw material according to weight portion is 9 parts of hirudin, 12 parts of biotin, cigarette 5 parts of amide, 6 parts of purple sweet potato anthocyanin, 13 parts of Aloe glue, 30 parts of dexamethasone acetate, 18 parts of oradol, 12 parts of diphenhydramine, south 20 parts of candelilla Syringaresinol, 13 parts of chlorphenamine.
A kind of preparation method of the plaster treating skin pruritus, concretely comprises the following steps：
First, by hirudin, biotin, nicotiamide, purple sweet potato anthocyanin, Aloe glue, dexamethasone acetate, oradol, benzene Extra large Lamine, Vaccinium bracteatum Thunb. wood gum phenol, chlorphenamine mix, and constantly add water stirring, and mixing speed controls in 150r/min, and stirring terminates Afterwards, evaporation and concentration at 40 DEG C, until the density of concentrate reaches 1.12-1.13g/cm3, load in ointment tube, obtain final product treatment The plaster of skin pruritus.
Embodiment 3
A kind of plaster treating skin pruritus, the primary raw material according to weight portion is：0 part of HV1,13 parts of biotin, 6 parts of nicotiamide, 7 parts of purple sweet potato anthocyanin, 15 parts of Aloe glue, 31 parts of dexamethasone acetate, 21 parts of oradol, 14 parts of diphenhydramine, 21 parts of Vaccinium bracteatum Thunb. wood gum phenol, 14 parts of chlorphenamine.
A kind of preparation method of the plaster treating skin pruritus, concretely comprises the following steps：
First, by hirudin, biotin, nicotiamide, purple sweet potato anthocyanin, Aloe glue, dexamethasone acetate, oradol, benzene Extra large Lamine, Vaccinium bracteatum Thunb. wood gum phenol, chlorphenamine mix, and constantly add water stirring, and mixing speed controls in 170r/min, and stirring terminates Afterwards, evaporation and concentration at 50 DEG C, until the density of concentrate reaches 1.12-1.13g/cm3, load in ointment tube, obtain final product treatment The plaster of skin pruritus.
Embodiment 4
A kind of plaster treating skin pruritus, the primary raw material according to weight portion is：1 part of HV1,13 parts of biotin, 7 parts of nicotiamide, 8 parts of purple sweet potato anthocyanin, 16 parts of Aloe glue, 32 parts of dexamethasone acetate, 24 parts of oradol, 16 parts of diphenhydramine, 21 parts of Vaccinium bracteatum Thunb. wood gum phenol, 15 parts of chlorphenamine.
A kind of preparation method of the plaster treating skin pruritus, concretely comprises the following steps：
First, by hirudin, biotin, nicotiamide, purple sweet potato anthocyanin, Aloe glue, dexamethasone acetate, oradol, benzene Extra large Lamine, Vaccinium bracteatum Thunb. wood gum phenol, chlorphenamine mix, and constantly add water stirring, and mixing speed controls in 180r/min, and stirring terminates Afterwards, evaporation and concentration at 60 DEG C, until the density of concentrate reaches 1.12-1.13g/cm3, load in ointment tube, obtain final product treatment The plaster of skin pruritus.
Embodiment 5
A kind of plaster treating skin pruritus, the primary raw material according to weight portion is：2 parts of HV1,14 parts of biotin, 8 parts of nicotiamide, 10 parts of purple sweet potato anthocyanin, 17 parts of Aloe glue, 34 parts of dexamethasone acetate, 30 parts of oradol, 17 parts of diphenhydramine, 22 parts of Vaccinium bracteatum Thunb. wood gum phenol, 17 parts of chlorphenamine.
A kind of preparation method of the plaster treating skin pruritus, concretely comprises the following steps：
First, by hirudin, biotin, nicotiamide, purple sweet potato anthocyanin, Aloe glue, dexamethasone acetate, oradol, benzene Extra large Lamine, Vaccinium bracteatum Thunb. wood gum phenol, chlorphenamine mix, and constantly add water stirring, and mixing speed controls in 180r/min, and stirring terminates Afterwards, evaporation and concentration at 60 DEG C, until the density of concentrate reaches 1.12-1.13g/cm3, load in ointment tube, obtain final product treatment The plaster of skin pruritus.
Clinical experiment：
(1) clinical data：The present inventor carries out clinical observation treatment to 100 skin pruritus patients, wherein man 50, female 50, the age is between 22～65 years old.
(2) Therapeutic Method：Smear daily 6 times, smear 500mg every time.Dose adopts according to patient's practical situation at this It is adjusted in bright each dose interval, usual patients with mild adopts embodiment 1 plaster, and moderate patient adopts embodiment 3 plaster, weight Patient adopts embodiment 5 plaster.
(3) curative effect determinate standard：
Cure：Symptom all disappears；Main Physico-chemical tests index is normally.
Effective：Symptomatology eliminates or cardinal symptom eliminates；Physico-chemical tests index is normal.
Effectively：Cardinal symptom disappears substantially；Main Physico-chemical tests index makes moderate progress
Invalid：Main Physico-chemical tests index with treat before unchanged.
(4) clinical effectiveness：
Clinical cure 96 (96%), effective 3 (3%), effective 1 (1%), total effective rate is 100%.
It is obvious to a person skilled in the art that the invention is not restricted to the details of above-mentioned one exemplary embodiment, Er Qie In the case of the spirit or essential attributes of the present invention, the present invention can be realized in other specific forms.Therefore, no matter From the point of view of which point, embodiment all should be regarded as exemplary, and be nonrestrictive, the scope of the present invention is by appended power Profit requires rather than described above limits, it is intended that all in the implication and scope of the equivalency of claim by falling Change is included in the present invention.
Moreover, it will be appreciated that although this specification is been described by according to embodiment, not each embodiment only wraps Containing an independent technical scheme, only for clarity, those skilled in the art should for this narrating mode of description Using description as an entirety, the technical scheme in each embodiment can also form those skilled in the art through appropriately combined Understandable other embodiment.

Claims (6)

1. a kind of plaster treating skin pruritus is it is characterised in that the primary raw material according to weight portion is：Hirudin 8-12 part, Biotin 11-14 part, nicotiamide 4-8 part, purple sweet potato anthocyanin 5-10 part, Aloe glue 12-17 part, dexamethasone acetate 29-34 part, Oradol 15-30 part, diphenhydramine 11-17 part, Vaccinium bracteatum Thunb. wood gum phenol 18-22 part, chlorphenamine 10-17 part.
2. the plaster for the treatment of skin pruritus according to claim 1 is it is characterised in that the cream of described treatment skin pruritus Medicine, the primary raw material according to weight portion is：Hirudin 9-11 part, biotin 12-13 part, nicotiamide 5-7 part, purple sweet potato anthocyanin 6- 8 parts, Aloe glue 13-16 part, dexamethasone acetate 30-32 part, oradol 18-24 part, diphenhydramine 12-16 part, Vaccinium bracteatum Thunb. ebon Fat phenol 20-21 part, chlorphenamine 13-15 part.
3. the plaster for the treatment of skin pruritus according to claim 1 and 2 is it is characterised in that described treatment skin pruritus Plaster, the primary raw material according to weight portion is：0 part of HV1,13 parts of biotin, 6 parts of nicotiamide, 7 parts of purple sweet potato anthocyanin, reed 15 parts of luxuriant growth glue, 31 parts of dexamethasone acetate, 21 parts of oradol, 14 parts of diphenhydramine, 21 parts of Vaccinium bracteatum Thunb. wood gum phenol, chlorphenamine 14 Part.
4. a kind of preparation method of the described plaster for the treatment of skin pruritus as arbitrary in claim 1-3 is it is characterised in that concrete Step is：
First, hirudin, biotin, nicotiamide, purple sweet potato anthocyanin, Aloe glue, dexamethasone acetate, oradol, benzene sea are drawn Bright, Vaccinium bracteatum Thunb. wood gum phenol, chlorphenamine mix, and constantly add water stirring, and mixing speed controls in 150-180r/min, and stirring terminates Afterwards, evaporation and concentration at 40-60 DEG C, until the density of concentrate reaches 1.12-1.13g/cm3, load in ointment tube, obtain final product and control Treat the plaster of skin pruritus.
5. the preparation method of the plaster for the treatment of skin pruritus according to claim 4 is it is characterised in that stir in concrete steps Mix speed controlling in 170r/min.
6. according to claim 4 treatment skin pruritus plaster preparation method it is characterised in that in concrete steps in Evaporation and concentration at 50 DEG C.
CN201611020051.6A 2016-11-17 2016-11-17 Plaster for curing skin itch Pending CN106390104A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN201611020051.6A CN106390104A (en) 2016-11-17 2016-11-17 Plaster for curing skin itch

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Application Number Priority Date Filing Date Title
CN201611020051.6A CN106390104A (en) 2016-11-17 2016-11-17 Plaster for curing skin itch

Publications (1)

Publication Number Publication Date
CN106390104A true CN106390104A (en) 2017-02-15

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Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1157137A (en) * 1996-02-14 1997-08-20 牟广志 Cream for curing eczema
CN1736386A (en) * 2005-09-06 2006-02-22 贵州泛德制药有限公司 Pharmaceutical formulation for treating skin allergy and preparation process thereof
CN1840175A (en) * 2006-01-14 2006-10-04 周维海 Ointment of natural hirudin

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1157137A (en) * 1996-02-14 1997-08-20 牟广志 Cream for curing eczema
CN1736386A (en) * 2005-09-06 2006-02-22 贵州泛德制药有限公司 Pharmaceutical formulation for treating skin allergy and preparation process thereof
CN1840175A (en) * 2006-01-14 2006-10-04 周维海 Ointment of natural hirudin

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