CN106539817A - For treating ointment, the preparation method and its usage of acne - Google Patents
For treating ointment, the preparation method and its usage of acne Download PDFInfo
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- CN106539817A CN106539817A CN201611009448.5A CN201611009448A CN106539817A CN 106539817 A CN106539817 A CN 106539817A CN 201611009448 A CN201611009448 A CN 201611009448A CN 106539817 A CN106539817 A CN 106539817A
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- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
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Abstract
The present invention relates to a kind of ointment, and in particular to a kind of ointment for treating acne, preparation method and its usage.The present invention is used for the ointment for treating acne, including substrate and crude drug, wherein crude drug includes 5～100 parts of 500～2000 parts of doxycycline hydrochloride, 800～2500 parts of chloromycetin, 500～2000 parts of QUMIXIN emulsifiable paste, 500～2000 parts of vitamin C, 10～100 parts of glucocorticoid, 10～100 parts of vitamin B2 and Cyproheptadine Hydrochloride.The ointment prescription for treating acne of the present invention is unique, evident in efficacy, through unique compatibility of the prescription, each medicine in crude drug is not only able to the effect for playing original medicine, after combination, its clinical efficacy further can be strengthened simultaneously, sebum secretion is effectively have adjusted, intrafollicular toxin and harmful substance is discharged, is inherently eliminated the symptoms such as acne, acne, simultaneously to desalinating acne print, polishing pox hole has significant curative effect.
Description
Technical field
The present invention relates to a kind of ointment, and in particular to a kind of ointment for treating acne, preparation method and its usage.
Background technology
Acne (being commonly called as acne, comedo) is a kind of chronic inflammatory skin disease of sebaceous gland, its have various morbidities because
Element, it is considered that its pathogeny is mainly relevant with hypersteatosiss and androgen secretion increase, is mainly swashed by male
The excessive secretion of the sebum that element, testosterone cause is so as to the pilosebaceous unit pipe keratinization for being formed, and thus caused is used for
The clogging of pores of sebum secretion, pilosebaceous duct blocking, bacterium infection and hair follicle inflammation etc..Acne is common in budding
Teenager, increases sebum secretion in particular with increasing for human body androgen after adolescence, while pilosebaceous unit causes angle
Changing exception causes catheter blockage, dyssebacia to form micropowder thorn.Its bacterium infection mainly due to propionibacterium acness and
The amount reproduction of the pathogenic bacterias such as gold-coloured staphylococci.Additionally, pathogenesis of acne is relevant with sebum abnormal secretion, multiple-microorganism in hair follicle
Amount reproduction, sebum are acted on by microorganism propionibacterium acness, Staphylococcus albus esterase, produce more free-fat
Acid, makes hair follicle and perifollicolar produce inflammatory reaction, and acne wall produces collapse and free fatty enters neighbouring corium, plus
Upper bacterium infection produces inflammation, produces pimple, pustule or cyst etc..
As acne can affect appearance, especially appearance, thus which often brings very big mental burden to patient, especially
Which is to affect teen-age working and learning, to teen-age psychology and social generation considerable influence.Simultaneously as acne is more difficult
Cure and relapse rate is higher, therefore, research and develop a kind of focus of medicine that can effectively cure acne also just into research and be located.
The medicine of existing treatment acne is divided into for oral administration and two kinds of external application.Oral medicine belongs to prescription drugss, and short run effect is preferable,
But which adopts to swallow to take and enters in digestion, and by intestinal absorption, the property of medicine will be comprehended and change, and easily produce
, easily there are the phenomenons such as Nausea and vomiting, loss of appetite, skin allergy, skin pruritus, redness in raw untoward reaction and side effect；This
Outer its is difficult to control the palindromia, cures the symptoms, not the disease.And application compress major part therapeutic effect has certain limitation, its big portion
Point only there is single antiinflammatory to skin surface, sterilization etc. to act on, and fundamentally can not carry out bactericidal antiphlogistic, heat-clearing and toxic substances removing,
Anti-acne granulation promoting, it is impossible to anti-acne, raw skin are repaiied into the synthesis effect such as skin, beauty and is combined together, make patient stay after healing compared with
The cicatrix of depth, acne print, curative effect is not obvious, and processing technology is relative complex.Generally speaking, the product of existing treatment acne is deposited
It is not good in therapeutic effect, easily rebound, it is expensive, there are toxic and side effects, Most patients are difficult to bear.
In view of this, it is special to propose the present invention.
The content of the invention
The first object of the present invention is to provide a kind of ointment for treating acne, and described ointment effectively can be adjusted
Cortex balance, therapeutic effect is good, action is rapid, not repeatedly, have no toxic side effect, disappear with heat-clearing and toxic substances removing, blood circulation promoting and blood stasis dispelling, sterilization
Comprehensive effect of inflammation, anti-acne granulation promoting, beauty and skin lightening moisturizing.
The second object of the present invention is to provide a kind of preparation method for treating the ointment of acne, the preparation side
Method is simple, and simple operation is cost-effective, the ointment for treating acne prepared by the preparation method, product stability
It is good, it is cheap, at utmost remain the medicinal efficacy of each crude drug.
The third object of the present invention is to provide a kind of application for treating the ointment of acne, and described ointment is using outer
The mode for applying administration is applied in different types of acne such as acne type acne, Acne conglobata or nodular type acne etc., also may be used
For the treatment of dermatitis or eczema etc., with efficiency high is cured, work rapid, effect of stable curative effect, while having moisturizing, carrying
The effect of skin lightening color.
For achieving the above object, the technical solution used in the present invention is：
The present invention provides a kind of ointment for treating acne, including substrate and crude drug, described crude drug include with
The component of lower parts by weight：500～2000 parts of doxycycline hydrochloride, 800～2500 parts of chloromycetin, QUMIXIN emulsifiable paste 500～
2000 parts, 500～2000 parts of vitamin C, 10～100 parts of glucocorticoid, 10～100 parts of vitamin B2 and Cyproheptadine Hydrochloride
5～100 parts.
Optionally, in the present invention, described crude drug includes the component of following parts by weight：Doxycycline hydrochloride 650～
1500 parts, 1200～2000 parts of chloromycetin, 650～1500 parts of QUMIXIN emulsifiable paste, 650～1500 parts of vitamin C, sugared cortical hormone
10～50 parts of 20～80 parts of element, 20～80 parts of vitamin B2 and Cyproheptadine Hydrochloride.
Optionally, in the present invention, described crude drug includes the component of following parts by weight：Doxycycline hydrochloride 800～
1000 parts, 1800～1875 parts of chloromycetin, 800～1000 parts of QUMIXIN emulsifiable paste, 800～1000 parts of vitamin C, sugared cortical hormone
20～40 parts of 40～50 parts of element, 40～50 parts of vitamin B2 and Cyproheptadine Hydrochloride.
Optionally, in the present invention, described substrate is vaseline, or vaseline and lanoline, or vaseline and height
Fatty alcohol；
The substrate is calculated by weight as 8000～20000 parts, preferably 10000～15000 parts, more preferably 11500～
12500 parts.
Optionally, in the present invention, in the vaseline and lanoline, weight ratio shared by vaseline is 80%～90%, described
In vaseline and high fat alcohol, weight ratio shared by vaseline is 80%～90%.
Optionally, in the present invention, per gram of QUMIXIN emulsifiable paste is mainly composed of the following components：10 milli of Miconazole Nitrate
Gram, 3000 unit of 1 milligram of triamcinolone acetonide acetate and polygynax.
Optionally, in the present invention, the glucocorticoid is dexamethasone or betamethasone.
The present invention also provides a kind of described preparation method for treating the ointment of acne, specifically, including following system
Standby step：
(1) weigh each crude drug by aforesaid arbitrary parts by weight, by chloromycetin, doxycycline hydrochloride, glucocorticoid,
Cyproheptadine Hydrochloride, vitamin B2 and vitamin C are ground into powder, and cross 100～200 mesh sieves, and mix homogeneously obtains mixed material
Medicated powder；
(2) with vaseline or vaseline and lanoline or vaseline and high fat alcohol as substrate, by the QUMIXIN for weighing breast
Cream is added in substrate, is stirred, and obtains mixed-matrix；
(3) the mixed material medicated powder in step (1) is added in the mixed-matrix in step (2), is mixed
Uniformly so as to blend together paste, obtain final product the ointment for treating acne.
Further, in the step (1), raw material drugs of chloramphenicol, doxycycline hydrochloride, glucocorticoid are weighed successively first
It is ground into powder with Cyproheptadine Hydrochloride, then after mixing with vitamin B2 and vitamin C powder, crosses 100～200 mesh sieves, mixing
Uniformly, obtain mixed material medicated powder.
It should be noted that can carry out according to step (1), step (2) successively in the present invention, it is also possible to according to step
(2), step (1) is carried out, and finally mixed-matrix is mixed homogeneously with mixed material medicated powder so as to blend together paste, you can.
Present invention also offers it is a kind of for treat the ointment of acne prepare treatment acne medicine in application.
Using the ointment for treating acne of the present invention, it is used for acne type acne, aggretion type in the way of external application is administered
Acne, fulminant acne, nodular type acne, senile acne and medicine type acne etc..Relative to oral medicine, given using external application
Mode, is difficult to cause patient's untoward reaction after use and side effect, and safety is good, and therapeutic effect is more preferable.
Compared with prior art, the beneficial effects of the present invention is：
(1) provided by the present invention for the ointment for the treatment of acne, prescription is unique, evident in efficacy, through the uniqueness of the prescription
Compatibility, each medicine in crude drug are not only able to the effect for playing original medicine, while its curative effect can more enter one after combination
Step is strengthened, and effectively have adjusted sebum secretion, discharges intrafollicular toxin and harmful substance, is inherently eliminated acne, acne etc.
Symptom, finally desalinates acne print, polishes and all cheat, with effectively Comprehensive Treatment acne repairing the comprehensive of scar simultaneously nourish skin again
Cooperation is used.
(2) ointment of the present invention, can effectively adjust cortex balance, and treating both the principal and secondary aspects of a disease cures efficiency high, and work rapid, treatment
Effect is stable, and do not rebound, it is without any side effects, with heat-clearing and toxic substances removing, blood circulation promoting and blood stasis dispelling, bactericidal antiphlogistic, anti-acne granulation promoting and
Comprehensive effect of beauty.
(3) the crude drug component for adopting is readily available, and cheap, and allergy rate is low, and zest is little, can promote people
Body itself adjusts metabolism, while realizing the effectively treatment to acne etc., highlights can patient skin whitening, the colour of skin, skin quality
Improve, it is to avoid acne regenerates.
(4) present invention adopt the preparation method for treating the ointment of acne is simple, easy to operate, flow process safety, it is whole
Individual preparation process does not need special equipment, cost-saved, time-consuming, and obtained product stability is good, maximum journey
Degree remains the medicinal efficacy of each crude drug.
(5) provided by the present invention for the ointment for the treatment of acne, can be used to treat the acne such as acne type of different types
Acne, Acne conglobata, fulminant acne, nodular type acne, senile acne and medicine type acne etc., it can also be used to treat skin
Scorching, eczema and vinasse nose etc., therapeutic effect is good, need not strictly prohibit mouth in use, and patient can be considered as sleeping
Dormancy facial film is equally used, easy to use, cheap, with good market prospect.
Specific embodiment
Embodiment of the present invention is described in detail below in conjunction with embodiment, but those skilled in the art will
Understand, the following example is merely to illustrate the present invention, and is not construed as limiting the scope of the present invention.It is unreceipted concrete in embodiment
Condition person, the condition advised according to normal condition or manufacturer are carried out.Agents useful for same or the unreceipted production firm person of instrument, are
The conventional products that commercially available purchase is obtained can be passed through.
According to an aspect of the present invention, the invention provides a kind of ointment for treating acne, including substrate and original
Material medicine, described crude drug include the component of following parts by weight：500～2000 parts of doxycycline hydrochloride, chloromycetin 800～
2500 parts, 500～2000 parts of QUMIXIN emulsifiable paste, 500～2000 parts of vitamin C, 10～100 parts of glucocorticoid, vitamin B2
10～100 parts and 5～100 parts of Cyproheptadine Hydrochloride.
The present invention is by will make with crude drug combination the effects such as removing toxic substances, antibacterial, antiinflammatory, antiallergic, antipruritic, moisturizing
With, cortex balance can be effectively adjusted, rapid, effective treatment of the realization to acne is made with good effect, instant effect, nontoxic pair
With, and skin whitening, the advantages of improve skin quality.
The doxycycline hydrochloride belongs to semi-synthetic tetracycline antibiotics, is broad-spectrum antibacterial agent, with bactericidal action, can
Increase bacterial cell membrane permeability, important substance outflow in thalline, which is mainly combined with target protein by bacterial membrane plays suppression
Make and use, treatment acne, cicatrix etc..Meanwhile, there is doxycycline hydrochloride low cheap, molecular weight, water solublity and tissue to ooze
The features such as permeability is good, which is highly lipophilic can to penetrate the abundant environment of pilosebaceous unit matter, and then plays sterilization, antibacterial work
With.Additionally, doxycycline hydrochloride can have aobvious with various other antiandrogen Drug combinations, such as polygynax
The synergism of work and more preferably effect.Due to the extremely strong water solublity of doxycycline hydrochloride and highly lipophilic, which passes through external application
Effect can be more preferable, will not cause the untoward reaction of digestive tract etc..
In the present invention, the typical but non-limiting content of the doxycycline hydrochloride is：500 parts, 600 parts, 700 parts, 800
Part, 900 parts, 1000 parts, 1100 parts, 1200 parts, 1300 parts, 1400 parts, 1500 parts, 1600 parts, 1700 parts, 1800 parts, 1900
Part or 2000 parts.
The chloromycetin can be used for the infection such as typhoid fever, paratyphoid fever and other salmonella, have suppression to staphylococcus aureuses
Make and use, be a kind of antibacterial.Its by it is fat-soluble can disperse enter bacterial cell in, mainly act on antibacterial 70s ribosome
50s subunits, suppress transpeptidase, make the growth of peptide chain be obstructed, it is suppressed that the formation of peptide chain, so as to prevent the synthesis of protein,
Play bactericidal action.
In the present invention, the typical but non-limiting content of the chloromycetin is：800 parts, 900 parts, 1000 parts, 1100 parts,
1200 parts, 1300 parts, 1400 parts, 1500 parts, 1600 parts, 1700 parts, 1800 parts, 1900 parts, 2000 parts, 2100 parts, 2200 parts,
2300 parts, 2400 parts or 2500 parts.
The QUMIXIN emulsifiable paste can be applicable to eczema, contact dermatitis, seborrheic dermatitis, neurodermatitiss, tinea corporis, tinea cruris
And the symptom such as tinea manus and pedis, it is with antiinflammatory, antiallergic and the effect such as antipruritic, skin-penetrating higher.
In the present invention, the typical but non-limiting content of the QUMIXIN emulsifiable paste is：500 parts, 600 parts, 700 parts, 800
Part, 900 parts, 1000 parts, 1100 parts, 1200 parts, 1300 parts, 1400 parts, 1500 parts, 1600 parts, 1700 parts, 1800 parts, 1900
Part or 2000 parts.
The glucocorticoid is the steroid hormone of a class adrenocortical secretion, can be applicable to psoriasiss, eczema, connects
The symptoms such as tactile property dermatitis, act on stronger antiinflammatory, antiallergic, immunosuppressant and mithridatism etc..
In the present invention, the typical but non-limiting content of the glucocorticoid is：10 parts, 20 parts, 30 parts, 40 parts, 50
Part, 60 parts, 70 parts, 80 parts, 90 parts or 100 parts.
The Cyproheptadine Hydrochloride can be used for allergic conditions, such as urticaria, papular urticaria, eczema or skin pruritus
Deng with preferable antiallergic effect, while with the effect for strengthening immunologic function.Its histamine discharged in passing through tissue
H1 receptors on competitive effect cell, prevent anaphylactoid outbreak, release the cause convulsion and hyperemization of histamine, anti-so as to play
Allergy is acted on.
In the present invention, the typical but non-limiting content of the Cyproheptadine Hydrochloride is：5 parts, 10 parts, 15 parts, 20 parts, 25
Part, 30 parts, 35 parts, 40 parts, 45 parts, 50 parts, 55 parts, 60 parts, 65 parts, 70 parts, 75 parts, 80 parts, 85 parts, 90 parts, 95 parts or 100
Part.
The vitamin C can be applicable to prevent vitamin C deficiency, it can also be used to which various acute and chronics are infected also known as L-AA
The auxiliary treatment of disease and purpura etc., as antioxidant, can improve the immunity of human body, can improve skin quality.Human body skin
Color depends primarily on melanic content in skin, in the basal layer of epidermis iuntercellular of people, is dispersed with melanocyte, and it contains
Tryrosinase can be by oxidizing tyrosine into polysaccharide, centre finally just can generate black again through a series of metabolic process
Element.Melanin generation is more, and skin is pitch-darker；Conversely, then skin is more pale.And the cheese ammonia that has its source in that melanin is generated
Sour enzyme, the L-Tyrosine in melanocyte are converted to DOPA quinone in the presence of it, then form eumelanin through oxidation, are formed
Melanin progressively reach the surface of skin with the normal metabolism of skin, last and aging cutin is shelled together naturally
Fall.If skin metabolism has some setbacks, substantial amounts of pigementation can be caused, and in localized clusters, the color of skin will be deepened
Or formation speckle causes skin uneven.And vitamin C can then prevent the synthesis of TYR enzyme, DOPA is prevented further to aoxidize
For dopachrome, and the DOPA enzyme for making to have synthesized is reduced to DOPA, and then prevents melanic synthesis.
In the present invention, the typical but non-limiting content of the vitamin C is：500 parts, 600 parts, 700 parts, 800 parts,
900 parts, 1000 parts, 1100 parts, 1200 parts, 1300 parts, 1400 parts, 1500 parts, 1600 parts, 1700 parts, 1800 parts, 1900 parts or
2000 parts.
The vitamin B2 is called riboflavin, can be applicable to the symptoms such as angular cheilitises, pimple, eczema or dermatitis.Which can promote
The regeneration of cell, is promoted the normal growth of skin, hair etc., is combined together with other materials, can affect biological oxidation and energy
Amount metabolism.
In the present invention, the typical but non-limiting content of the vitamin B2 is：10 parts, 20 parts, 30 parts, 40 parts, 50 parts,
60 parts, 70 parts, 80 parts, 90 parts or 100 parts.
Used as a kind of preferred implementation of the present invention, described crude drug includes the component of following parts by weight：Hydrochloric acid
650～1500 parts of doxycycline, 1200～2000 parts of chloromycetin, 650～1500 parts of QUMIXIN emulsifiable paste, vitamin C 650～
10～50 parts of 1500 parts, 20～80 parts of glucocorticoid, 20～80 parts of vitamin B2 and Cyproheptadine Hydrochloride.
Used as a kind of preferred implementation of the present invention, described crude drug includes the component of following parts by weight：Hydrochloric acid
800～1000 parts of doxycycline, 1800～1875 parts of chloromycetin, 800～1000 parts of QUMIXIN emulsifiable paste, vitamin C 800～
20～40 parts of 1000 parts, 40～50 parts of glucocorticoid, 40～50 parts of vitamin B2 and Cyproheptadine Hydrochloride.
In the present invention, by further adjustment and optimization to each raw material components consumption, so as to further increase this
Therapeutic effect of the bright ointment to acne.
Used as a kind of preferred implementation of the present invention, described substrate is vaseline or vaseline and lanoline, or
It is vaseline and high fat alcohol；
The substrate is calculated by weight as 8000～20000 parts, preferably 10000～15000 parts, more preferably 11500～
12500 parts.
In the present invention, the typical but non-limiting content of the substrate is：8000 parts, 9000 parts, 10000 parts, 11500
Part, 12000 parts, 12500 parts, 13000 parts, 13500 parts, 14000 parts, 14500 parts, 15000 parts, 16000 parts, 17000 parts,
18000 parts, 19000 parts or 20000 parts.
Used as a kind of preferred implementation of the present invention, in the vaseline and lanoline, shared by vaseline, weight ratio is
80%～90%, in the vaseline and high fat alcohol, weight ratio shared by vaseline is 80%～90%.
In the present invention, using vaseline, or vaseline and lanoline, or vaseline and high fat alcohol are substrate, wherein, it is all
Intellectual circle has good lubrication moisture-keeping function, and effective agent adhesive force is strong, and lubricating maintenance effect is obvious.And vaseline and sheep
The mixture of hair fat or vaseline and high fat alcohol is substrate, can improve the hardness of vaseline, strengthens the penetrance of vaseline,
Itself is stable in properties, is difficult to become sour.Each crude drug can be increased as substrate by the use of the mixture of vaseline or vaseline to exist
Dissolubility in substrate, increases the penetrating power of pharmaceutical through skin, improves therapeutic effect of the crude drug to acne etc. so that ointment
Become more satiny, allow patient to feel more comfortable.
In the present invention, in the vaseline and lanoline, shared by vaseline, weight than typical but non-limiting content is：
80%th, 81%, 82%, 83%, 84%, 85%, 86%, 87%, 88%, 89% or 90%.
In the present invention, in the vaseline and high fat alcohol, weight shared by vaseline is than typical but non-limiting content
For：80%th, 81%, 82%, 83%, 84%, 85%, 86%, 87%, 88%, 89% or 90%.
Used as a kind of preferred implementation of the present invention, per gram of QUMIXIN emulsifiable paste is mainly composed of the following components：Nitre
10 milligrams of sour miconazole, 3000 unit of 1 milligram of triamcinolone acetonide acetate and polygynax.
The Miconazole Nitrate is broad-spectrum antifungal medicine, has antibacterial action to some gram-positive bacterias；The acetic acid is bent
An Naide is glucocorticoid medicine, and external has antiinflammatory, antiallergic and itching-relieving action, can eliminate that local is non-infectious to draw
The heating that rises, redness, can reduction of patient pruritis rapidly；The polygynax has to various Grain-positives and negative bacteria
Good antibacterial action, for eczema, contact dermatitis, seborrheic dermatitis, neurodermatitiss, tinea corporis, tinea cruris and tinea manus and pedis etc..
Wherein, the polygynax and the compatibility of doxycycline hydrochloride, with the significant effect for cooperateing with, are more beneficial for quickly killing
Bacterium.
Used as a kind of preferred implementation of the present invention, the glucocorticoid is dexamethasone or betamethasone.
The dexamethasone or betamethasone are long-acting type glucocorticoid, with antibacterial, antiinflammatory, antianaphylactic effect,
Skin can be made to recover function as early as possible.
According to another aspect of the present invention, the preparation method for treating the ointment of acne of the invention employ as
Lower preparation scheme, including following preparation process：
Step (1), weighs each crude drug by aforesaid arbitrary parts by weight, by chloromycetin, doxycycline hydrochloride, sugared cortex
Hormone, Cyproheptadine Hydrochloride, vitamin B2 and vitamin C are ground into powder, and cross 100～200 mesh sieves, and mix homogeneously is mixed
Close raw material medicated powder；
Step (2), with vaseline or vaseline and lanoline or vaseline and high fat alcohol as substrate, by the song for weighing
The new emulsifiable paste of miaow is added in substrate, is stirred, is obtained mixed-matrix；
The mixed material medicated powder in step (3), just step (1) is added to the mixed-matrix in step (2)
In, mix homogeneously so as to blend together paste obtains final product the ointment for treating acne.
As a kind of preferred implementation of the present invention, in the step (1), raw material drugs of chloramphenicol, salt are weighed successively first
Sour doxycycline, glucocorticoid and Cyproheptadine Hydrochloride are ground into powder, then mix with vitamin B2 and vitamin C powder
Afterwards, 100～200 mesh sieves are crossed, mix homogeneously obtains mixed material medicated powder.
In the present invention, mixed material medicated powder is crossed into 100～200 mesh sieves, can be applied in preparation process Chinese medicine powder evenly
It is more comfortable when on skin.
In the present invention, each crude drug is weighed in the order described above successively, can cause mixed effect more preferably, evenly.
According to another aspect of the present invention, the ointment provided by the present invention for treating acne is preparing treatment acne
Medicine in application.Using the present invention the ointment for treating acne, by external application be administered in the way of for acne type acne,
Acne conglobata, fulminant acne, nodular type acne, senile acne and medicine type acne, also apply be applicable to treat dermatitis, eczema
With vinasse nose etc..
Below in conjunction with embodiment and effect example, the present invention will be further described in detail.
Embodiment 1
A kind of ointment for treating acne, including substrate and crude drug, wherein, crude drug includes following parts by weight
Component：500 parts of doxycycline hydrochloride, 800 parts of chloromycetin, 500 parts of QUMIXIN emulsifiable paste, 500 parts of vitamin C, dexamethasone 10
5 parts of part, 10 parts of vitamin B2 and Cyproheptadine Hydrochloride.
Above-mentioned substrate is vaseline, and the content of vaseline is 8000 parts.
Embodiment 2
A kind of ointment for treating acne, including substrate and crude drug, wherein, crude drug includes following parts by weight
Component：650 parts of doxycycline hydrochloride, 1200 parts of chloromycetin, 650 parts of QUMIXIN emulsifiable paste, 650 parts of vitamin C, dexamethasone 20
10 parts of part, 20 parts of vitamin B2 and Cyproheptadine Hydrochloride.
Above-mentioned substrate is vaseline, and the content of vaseline is 10000 parts.
Embodiment 3
A kind of ointment for treating acne, including substrate and crude drug, wherein, crude drug includes following parts by weight
Component：1000 parts of doxycycline hydrochloride, 1875 parts of chloromycetin, 1000 parts of QUMIXIN emulsifiable paste, 1000 parts of vitamin C, dexamethasone
20 parts of 50 parts, 50 parts of vitamin B2 and Cyproheptadine Hydrochloride.
Above-mentioned substrate is vaseline, and the content of vaseline is 12500 parts.
Embodiment 4
A kind of ointment for treating acne, including substrate and crude drug, wherein, crude drug includes following parts by weight
Component：1000 parts of doxycycline hydrochloride, 1875 parts of chloromycetin, 1000 parts of QUMIXIN emulsifiable paste, 1000 parts of vitamin C, betamethasone
20 parts of 50 parts, 50 parts of vitamin B2 and Cyproheptadine Hydrochloride.
It is 12500 parts that above-mentioned substrate is the content of vaseline and lanoline, vaseline and lanoline, vaseline and lanoline
Weight ratio shared by middle vaseline is 85%.
Embodiment 5
A kind of ointment for treating acne, including substrate and crude drug, wherein, crude drug includes following parts by weight
Component：1500 parts of doxycycline hydrochloride, 2000 parts of chloromycetin, 1500 parts of QUMIXIN emulsifiable paste, 1500 parts of vitamin C, betamethasone
50 parts of 80 parts, 80 parts of vitamin B2 and Cyproheptadine Hydrochloride.
It is 15000 parts that above-mentioned substrate is the content of vaseline and lanoline, vaseline and lanoline, vaseline and lanoline
Weight ratio shared by middle vaseline is 88%.
Embodiment 6
A kind of ointment for treating acne, including substrate and crude drug, wherein, crude drug includes following parts by weight
Component：1800 parts of doxycycline hydrochloride, 2150 parts of chloromycetin, 1800 parts of QUMIXIN emulsifiable paste, 1800 parts of vitamin C, betamethasone
30 parts of 80 parts, 80 parts of vitamin B2 and Cyproheptadine Hydrochloride.
Above-mentioned substrate is vaseline, and the content of vaseline is 16000 parts.
Embodiment 7
A kind of ointment for treating acne, including substrate and crude drug, wherein, crude drug includes following parts by weight
Component：2000 parts of doxycycline hydrochloride, 2500 parts of chloromycetin, 1800 parts of QUMIXIN emulsifiable paste, 1900 parts of vitamin C, betamethasone
70 parts of 90 parts, 90 parts of vitamin B2 and Cyproheptadine Hydrochloride.
It is 18500 parts that above-mentioned substrate is the content of vaseline and high fat alcohol, vaseline and high fat alcohol, vaseline and height
In fatty alcohol, weight ratio shared by vaseline is 82%.
Embodiment 8
A kind of ointment for treating acne, including substrate and crude drug, wherein, crude drug includes following parts by weight
Component：1200 parts of doxycycline hydrochloride, 2100 parts of chloromycetin, 1000 parts of QUMIXIN emulsifiable paste, 1100 parts of vitamin C, dexamethasone
30 parts of 60 parts, 60 parts of vitamin B2 and Cyproheptadine Hydrochloride.
It is 11500 parts that above-mentioned substrate is the content of vaseline and high fat alcohol, vaseline and high fat alcohol, vaseline and height
In fatty alcohol, weight ratio shared by vaseline is 90%.
Embodiment 9
The above-mentioned preparation method for treating the ointment of acne, including following preparation process：
Step (1), the parts by weight as described in above-described embodiment 1 weigh each crude drug, by chloromycetin, the how western ring of hydrochloric acid
Element, glucocorticoid, Cyproheptadine Hydrochloride, vitamin B2 and vitamin C are ground into powder, and cross 150 mesh sieves, and mix homogeneously is obtained
To mixed material medicated powder；
Step (2), the parts by weight as described in above-described embodiment 1 weigh vaseline, the song that will be weighed by above-described embodiment 1
The new emulsifiable paste of miaow is added in substrate vaseline, is stirred, is obtained mixed-matrix；
Step (3), above-mentioned mixed material medicated powder is added in the mixed-matrix of QUMIXIN emulsifiable paste and vaseline, and mixing is equal
It is even so as to blend together paste, obtain final product the ointment for treating acne.
Embodiment 10
The above-mentioned preparation method for treating the ointment of acne, including following preparation process：
Step (1), the parts by weight as described in above-described embodiment 3 first weigh the how western ring of raw material drugs of chloramphenicol, hydrochloric acid successively
Element, dexamethasone and Cyproheptadine Hydrochloride are ground into powder, then after mixing with vitamin B2 and vitamin C powder, cross 150 mesh
Sieve, mix homogeneously obtain mixed material medicated powder；
Step (2), the parts by weight as described in above-described embodiment 3 weigh vaseline, the song that will be weighed by above-described embodiment 3
The new emulsifiable paste of miaow is added in substrate vaseline, is stirred, is obtained mixed-matrix；
Step (3), above-mentioned mixed material medicated powder is added in the mixed-matrix of QUMIXIN emulsifiable paste and vaseline, and mixing is equal
It is even so as to blend together paste, obtain final product the ointment for treating acne.
Embodiment 11
The above-mentioned preparation method for treating the ointment of acne, including following preparation process：
Step (1), the parts by weight as described in above-described embodiment 5 first weigh the how western ring of raw material drugs of chloramphenicol, hydrochloric acid successively
Element, dexamethasone and Cyproheptadine Hydrochloride are ground into powder, then after mixing with vitamin B2 and vitamin C powder, cross 150 mesh
Sieve, mix homogeneously obtain mixed material medicated powder；
Step (2), the parts by weight as described in above-described embodiment 5 weigh vaseline and lanoline, will be by above-described embodiment 5
The QUMIXIN emulsifiable paste for weighing is added in substrate vaseline and lanoline, is stirred, is obtained mixed-matrix；
Above-mentioned mixed material medicated powder is added to the mixed-matrix of QUMIXIN emulsifiable paste and vaseline and lanoline by step (3)
In, mix homogeneously so as to blend together paste obtains final product the ointment for treating acne.
Embodiment 12
The above-mentioned preparation method for treating the ointment of acne, including following preparation process：
Step (1), the parts by weight as described in above-described embodiment 6 first weigh the how western ring of raw material drugs of chloramphenicol, hydrochloric acid successively
Element, dexamethasone and Cyproheptadine Hydrochloride are ground into powder, then after mixing with vitamin B2 and vitamin C powder, cross 100 mesh
Sieve, mix homogeneously obtain mixed material medicated powder；
Step (2), the parts by weight as described in above-described embodiment 6 weigh vaseline, the song that will be weighed by above-described embodiment 6
The new emulsifiable paste of miaow is added in substrate vaseline, is stirred, is obtained mixed-matrix；
Step (3), above-mentioned mixed material medicated powder is added in the mixed-matrix of QUMIXIN emulsifiable paste and vaseline, and mixing is equal
It is even so as to blend together paste, obtain final product the ointment for treating acne.
Embodiment 13,14
The above-mentioned preparation method for treating the ointment of acne, including following preparation process：
Step (1), first to weigh crude drug chlorine successively mould for parts by weight as described in above-described embodiment 7, embodiment 8 respectively
Element, doxycycline hydrochloride, dexamethasone and Cyproheptadine Hydrochloride are ground into powder, then mixed with vitamin B2 and vitamin C powder
After conjunction, 200 mesh sieves are crossed, mix homogeneously obtains mixed material medicated powder；
Step (2), respectively the parts by weight as described in above-described embodiment 7, embodiment 8 weigh vaseline and high fat alcohol,
The QUMIXIN emulsifiable paste for weighing is added in substrate vaseline and high fat alcohol, is stirred, is obtained mixed-matrix；
Above-mentioned mixed material medicated powder is added to the mixed base of QUMIXIN emulsifiable paste and vaseline and high fat alcohol by step (3)
In matter, mix homogeneously so as to blend together paste obtains final product the ointment for treating acne.
Effect example 1
60 volunteers, selected from the patient that acne symptom is acne, tuberosity and pustule etc., wherein male 30, women 30
Volunteer is randomly divided into 3 groups by name, wherein every group of women 10, male 10.
The ointment for treating acne for asking first group of volunteer to prepare in the painting embodiment of the present invention 9 daily respectively；The
Two groups of volunteers are applied daily with the ointment for treating acne prepared in the embodiment of the present invention 10；3rd group of volunteer applies daily
With the ointment for treating acne prepared in the embodiment of the present invention 11, three groups of volunteers are applied with 1 time daily, each to apply use
5g。
Each group volunteer is paid a return visit at interval of a period of time, observe the Cure of patient, facial acne disappears, and
Without recurrence to cure completely in 3 months, and according to curing, improvement significantly, slightly improves and without improving also without deteriorating etc.
Level Four evaluation criterion, asks volunteer to evaluate and test the improvement acne effect of ointment, and records statistics, statistical result such as following table institute
Show：
After the ointment that continuous painting is prepared with embodiment of the present invention 9-11 1 week, volunteer's skin is detected, found
The skin of part volunteer slightly can improve；After continuous painting was with 4 weeks, finds most of volunteer's improvement significantly, more have portion
Volunteer is divided to cure；After continuously applying with 12 weeks, most of volunteer has cured, and the volunteer for having cured without
Bounce-back, without recurrence, the colour of skin of volunteer substantially bleaches, and becomes more flexible, and skin surface flatness substantially makes moderate progress, flesh
Skin whitening and glossy, does not find any side effect.
The experiment more than understands, embodiment of the present invention 9-11 and total has in treatment speed for treating the ointment of acne
The conventional therapy means of current treatment acne are significantly better than in efficiency all, while the effectively treatment to acne is realized, energy
Enough so that patient skin whitening, improves skin quality, it is to avoid acne regenerates.It should be noted that the present invention have chosen embodiment 9-11
As experimental example, by further experimental studies have found that, equally, embodiments of the invention 12-14 is had with embodiment 9-11
There is same effect, can realize the effectively treatment to acne.
Although with specific embodiment illustrate and describing the present invention, but it will be appreciated that without departing substantially from the present invention's
Many other changes and modification can be made in the case of spirit and scope.It is, therefore, intended that in the following claims
Including all such changes and modifications belonged in the scope of the invention.
Claims (10)
1. a kind of ointment for treating acne, including substrate and crude drug, it is characterised in that described crude drug includes following
The component of parts by weight：500～2000 parts of doxycycline hydrochloride, 800～2500 parts of chloromycetin, QUMIXIN emulsifiable paste 500～2000
Part, 500～2000 parts of vitamin C, 10～100 parts of glucocorticoid, 10～100 parts of vitamin B2 and Cyproheptadine Hydrochloride 5～
100 parts.
2. the ointment for treating acne according to claim 1, it is characterised in that described crude drug includes following heavy
The component of amount number：650～1500 parts of doxycycline hydrochloride, 1200～2000 parts of chloromycetin, QUMIXIN emulsifiable paste 650～1500
Part, 650～1500 parts of vitamin C, 20～80 parts of glucocorticoid, 20～80 parts of vitamin B2 and Cyproheptadine Hydrochloride 10～50
Part.
3. the ointment for treating acne according to claim 1, it is characterised in that described crude drug includes following heavy
The component of amount number：800～1000 parts of doxycycline hydrochloride, 1800～1875 parts of chloromycetin, QUMIXIN emulsifiable paste 800～1000
Part, 800～1000 parts of vitamin C, 40～50 parts of glucocorticoid, 40～50 parts of vitamin B2 and Cyproheptadine Hydrochloride 20～40
Part.
4. the ointment for treating acne according to any one of claim 1-3, it is characterised in that described substrate is
Vaseline, or vaseline and lanoline, or vaseline and high fat alcohol；
The substrate is calculated by weight as 8000～20000 parts, preferably 10000～15000 parts, and more preferably 11500～12500
Part.
5. the ointment for treating acne according to claim 4, it is characterised in that all in the vaseline and lanoline
Weight ratio shared by intellectual circle be 80%～90%, in the vaseline and high fat alcohol weight ratio shared by vaseline be 80%～
90%.
6. the ointment for treating acne according to any one of claim 1-3, it is characterised in that per gram of bent miaow
New emulsifiable paste is mainly composed of the following components：10 milligrams of Miconazole Nitrate, 1 milligram of triamcinolone acetonide acetate and polygynax 3000 are single
Position.
7. the ointment for treating acne according to any one of claim 1-3, it is characterised in that the sugared cortical hormone
Element is dexamethasone or betamethasone.
8. a kind of preparation method for treating the ointment of acne as described in any one of claim 1-7, it is characterised in that
Including following preparation process：
(1) parts by weight as described in any one of claim 1-7 weigh each crude drug, by chloromycetin, doxycycline hydrochloride,
Glucocorticoid, Cyproheptadine Hydrochloride, vitamin B2 and vitamin C are ground into powder, excessively 100～200 mesh sieves, mix homogeneously,
Obtain mixed material medicated powder；
(2) with vaseline or vaseline and lanoline or vaseline and high fat alcohol as substrate, the QUMIXIN emulsifiable paste for weighing is added
Enter in substrate, stir, obtain mixed-matrix；
(3) the mixed material medicated powder in step (1) is added in the mixed-matrix in step (2), mix homogeneously,
Make which blend together paste, obtain final product the ointment for treating acne.
9. preparation method according to claim 8, it is characterised in that in the step (1), first weighs crude drug chlorine successively
Mycin, doxycycline hydrochloride, glucocorticoid and Cyproheptadine Hydrochloride are ground into powder, then with vitamin B2 and vitamin c powder
After the mixing of end, 100～200 mesh sieves are crossed, mix homogeneously obtains mixed material medicated powder.
10. according to any one of claim 1-7 for treat the ointment of acne prepare treatment acne medicine in
Using.
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| FR3064482A1 (en) * | 2017-04-03 | 2018-10-05 | Horus Pharma | TOPICAL COMPOSITION OF DOXYCYCLINE |
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| FR3064482A1 (en) * | 2017-04-03 | 2018-10-05 | Horus Pharma | TOPICAL COMPOSITION OF DOXYCYCLINE |
| WO2018185078A1 (en) | 2017-04-03 | 2018-10-11 | Horus Pharma | Topical doxycycline composition |
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