CN106309394A - Metronidazole oral sticking tablets and preparation method thereof - Google Patents
Metronidazole oral sticking tablets and preparation method thereof Download PDFInfo
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- CN106309394A CN106309394A CN201610964234.7A CN201610964234A CN106309394A CN 106309394 A CN106309394 A CN 106309394A CN 201610964234 A CN201610964234 A CN 201610964234A CN 106309394 A CN106309394 A CN 106309394A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/2027—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
- A61K9/006—Oral mucosa, e.g. mucoadhesive forms, sublingual droplets; Buccal patches or films; Buccal sprays
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2009—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2013—Organic compounds, e.g. phospholipids, fats
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
Abstract
The invention discloses metronidazole oral sticking tablets and a preparation method thereof. The metronidazole oral sticking tablets take metronidazole, Carbomer, hydroxypropyl methylcellulose, beta-cyclodextrin, sodium bicarbonate, menthol, sodium saccharin, talcum powder and magnesium stearate as raw materials, wherein the metronidazole is used for treating or preventing systematical or partial infection caused by anaerobic bacteria; the Carbomer has a gelling effect; the hydroxypropyl methylcellulose has a sticking effect; the beta-cyclodextrin has a slow-releasing effect; the sodium bicarbonate can be used for improving the pH (Potential of Hydrogen) value of an oral cavity of a patient and improving an acidic environment of the oral cavity; the menthol has the effects of relieving swelling and pain; the sodium saccharin has the effect of a flavoring agent; the talcum powder has the effect of lubricating; and the magnesium stearate has the effect of lubricating. The metronidazole oral sticking tablets prepared from the raw materials have a very high curative effect and have no side effect, and can be used for treating oral cavity diseases including oral ulcers, pharyngitis, toothache and the like caused by the anaerobic bacteria.
Description
Technical field
The present invention relates to treat anaerobism microbial oral disease field, particularly relate to a kind of metronidazole oral sticking tablets and
Its preparation method.
Background technology
Anaerobe is that a class is better than growing in aerobic environment under anaerobic, and can not at air (18% oxygen) and
(or) the epontic antibacterial of solid medium under 10% gas concentration lwevel.This bacterioid lacks complete metabolic enzyme body
System, its energy metabolism is carried out in the way of anaerobic fermentation.It can cause the infection of human body different parts, such as oral cavity infection etc.
Oral cavity infection easily causes the oral diseases such as oral ulcer, pharyngolaryngitis, toothache, periodontitis, gingivitis, pericoronitis.
The medicine treating oral anaerobe infection disease in the market has the medicines such as your de-, cydiodine of fan, although burst treatment oral cavity
The oral diseases such as infections, pharyngolaryngitis, toothache, periodontitis, gingivitis, pericoronitis have certain curative effect, but oral tablet dosage is big, hold
Easily cause side effect.
Summary of the invention
In view of this, the present invention provides a kind of metronidazole oral sticking tablets and preparation method thereof, it is possible to solve existing medicine
The technical problem that side effect is big.
The technical scheme is that and be achieved in that:
A kind of metronidazole oral sticking tablets, including the raw material of following parts by weight:
Preferably, including the raw material of following parts by weight:
Present invention also offers the preparation method of above-mentioned a kind of metronidazole oral sticking tablets, comprise the steps:
Saccharin sodium grinds to form the saccharin sodium fine powder of 50～100 mesh, and metronidazole pulverizing is the metronidazole powder of 50～100 mesh
End；After described saccharin sodium fine powder is mixed homogeneously with sodium bicarbonate, add described metronidazole powder, hypromellose, times he
Cyclodextrin, makes the mixed-powder of 30～50 mesh；
Mentholum is joined in the first ethanol solution, after being uniformly mixed, spray into watering can described mixed on a small quantity by several times
Close in powder, be sufficiently stirred for mixing；With the second ethanol solution, described mixed-powder uniform wet is made soft material again, and by soft material
Make the granule of 30～50 mesh；
After being mixed homogeneously with carbomer, Pulvis Talci by described granule, add magnesium stearate mixing, tabletting obtains metronidazole
Oral cavity sticking tablet；The weight of every described metronidazole oral sticking tablets is 36～48mg.
Preferably, described first ethanol solution is dehydrated alcohol, the mass concentration of described second ethanol solution be 93%～
97%.
Preferably, the volume of described first ethanol solution and the mass ratio of described Mentholum are (4mL～6mL): (3g～
5g)；Described first ethanol solution is (4～6) with the volume ratio of described second ethanol solution: (8～12).
Preferably, described metronidazole powder, described hypromellose, the side of described betacyclodextrin employing equal increments
Formula joins in the mixture of described saccharin sodium fine powder and described sodium bicarbonate.
The invention provides a kind of metronidazole oral sticking tablets and preparation method thereof, this metronidazole oral sticking tablets is with first nitre
Azoles, carbomer, hydroxypropyl methylcellulose, betacyclodextrin, sodium bicarbonate, Mentholum, saccharin sodium, Pulvis Talci, magnesium stearate are
Raw material, metronidazole is used for treating or prevent the microbial system of anaerobism or local infection；Carbomer has gelatification；Hydroxypropyl first
Base cellulose has adhesive effect；Betacyclodextrin plays slow releasing function；Sodium bicarbonate can improve patient's ph value of oral cavity, changes
Oral cavity acid environment；Mentholum can play the effect of reducing swelling and alleviating pain；Saccharin sodium plays the effect of correctives；Pulvis Talci plays lubrication
Effect；Magnesium stearate plays lubrication；The metronidazole oral sticking tablets that the present invention prepares by using above-mentioned raw materials
There is the highest curative effect, have no side effect, it is possible to effectively treat the oral cavities such as the microbial oral ulcer of anaerobism, pharyngolaryngitis, toothache
Disease.
Detailed description of the invention
The invention discloses a kind of metronidazole oral sticking tablets and preparation method thereof, those skilled in the art can use for reference this
Literary composition content, is suitably modified technological parameter and realizes.Special needs to be pointed out is, described similar replacement and change are to art technology
Being apparent from for personnel, they are considered as being included in the present invention.The method of the present invention and quoting has been passed through preferably
Embodiment is described, and related personnel substantially can be to side as herein described in without departing from present invention, spirit and scope
Method and application are modified or suitably change and combine, and realize and apply the technology of the present invention.
The invention provides a kind of metronidazole oral sticking tablets, including the raw material of following parts by weight:
The present invention is with metronidazole, carbomer, hydroxypropyl methylcellulose, betacyclodextrin, sodium bicarbonate, Mentholum, saccharin
Sodium, Pulvis Talci, magnesium stearate are raw material, and metronidazole is used for treating or prevent the microbial system of anaerobism or local infection；Card ripple
Nurse has gelatification；Hydroxypropyl methylcellulose has adhesive effect；Betacyclodextrin plays slow releasing function；Sodium bicarbonate can
Improve patient's ph value of oral cavity, change oral cavity acid environment；Mentholum can play the effect of reducing swelling and alleviating pain；Saccharin sodium plays correctives
Effect；Pulvis Talci plays the effect of lubrication；Magnesium stearate plays lubrication；By the first using above-mentioned raw materials to prepare
Nitre azoles oral cavity sticking tablet has the highest curative effect, has no side effect, it is possible to the effectively treatment microbial oral ulcer of anaerobism, throat
The oral diseases such as inflammation, toothache.
Metronidazole is used for treating or prevent the microbial system of anaerobism or local infection.In the present invention, the weight of metronidazole
Number is 3～8 parts；In an embodiment of the present invention, the parts by weight of metronidazole are 4～6 parts.
Carbomer plays the effect of gel.In the present invention, the parts by weight of carbomer are 7～10 parts；In the present invention
Embodiment in, the parts by weight of carbomer are 8～9 parts.
Hydroxypropyl methylcellulose plays the effect of binding agent.In the present invention, the parts by weight of hydroxypropyl methylcellulose are 7
～15 parts；In an embodiment of the present invention, the parts by weight of hydroxypropyl methylcellulose are 9～12 parts.
Betacyclodextrin plays slow releasing function.In the present invention, the parts by weight of betacyclodextrin are 5～15 parts；At this
In inventive embodiment, the parts by weight of betacyclodextrin are 8～12 parts.
Sodium bicarbonate can improve patient's ph value of oral cavity, changes oral cavity acid environment, thus improves metronidazole oral sticking tablets
Curative effect.In the present invention, the parts by weight of sodium bicarbonate are 0.5～3 part；In an embodiment of the present invention, sodium bicarbonate
Parts by weight are 1～2 part.
Mentholum can play the effect of reducing swelling and alleviating pain.In the present invention, the parts by weight of Mentholum are 0.3～2 part；?
In embodiments of the invention, the parts by weight of Mentholum are 0.8～1.5 part.
Saccharin sodium plays the effect of correctives.In the present invention, the parts by weight of saccharin sodium are 0.1～1 part；In the present invention
Embodiment in, the parts by weight of saccharin sodium are 0.3～0.7 part.
Pulvis Talci plays the effect of lubrication.In the present invention, talcous parts by weight are 0.3～1.5 part；In the present invention
Embodiment in, talcous parts by weight are 0.6～1.2 part.
Magnesium stearate plays lubrication.In the present invention, the parts by weight of magnesium stearate are 0.5～2.5 part；At this
In bright embodiment, the parts by weight of magnesium stearate are 1～2 part.
Present invention also offers the preparation method of a kind of metronidazole oral sticking tablets, comprise the steps:
Saccharin sodium grinds to form the saccharin sodium fine powder of 50～100 mesh, and metronidazole pulverizing is the metronidazole powder of 50～100 mesh
End；After being mixed homogeneously with sodium bicarbonate by saccharin sodium fine powder, add metronidazole powder, hypromellose, betacyclodextrin, system
Become the mixed-powder of 30～50 mesh；
Mentholum is joined in the first ethanol solution, after being uniformly mixed, spray into mixed powder by several times on a small quantity with watering can
In end, it is sufficiently stirred for mixing；With the second ethanol solution mixed-powder uniform wet made soft material again, and soft material is made 30～
The granule of 50 mesh；
After being mixed homogeneously with carbomer, Pulvis Talci by granule, add magnesium stearate mixing, tabletting obtains metronidazole oral cavity
Sticking tablet；The weight of every metronidazole oral sticking tablets is 36～48mg.
Wherein, metronidazole, carbomer, hydroxypropyl methylcellulose, betacyclodextrin, sodium bicarbonate, Mentholum, saccharin sodium,
Pulvis Talci, magnesium stearate are the most same as above, do not repeat them here.
The metronidazole oral sticking tablets that the present invention uses technique scheme to prepare has the highest curative effect, it is possible to
Effectively treat the oral diseases such as the microbial oral ulcer of anaerobism, pharyngolaryngitis, toothache.
Saccharin sodium grinds to form the saccharin sodium fine powder of 50～100 mesh, and metronidazole pulverizing is the metronidazole powder of 50～100 mesh
End, is of value to the uniformity improving raw material mixing, can also improve the human body absorption to medicine so that the curative effect of medicine simultaneously
High.In an embodiment of the present invention, the particle diameter of saccharin sodium fine powder is 70～90 mesh, and the particle diameter of metronidazole powder is 70～90 mesh.
After being mixed homogeneously with sodium bicarbonate by saccharin sodium fine powder again, add metronidazole powder, hypromellose, times his ring
Dextrin, makes the mixed-powder of 30～50 mesh；In an embodiment of the present invention, metronidazole powder, hypromellose, times his ring
Dextrin uses the mode of equal increments to add, thus improves the uniformity of dosage units of product.
Mentholum is joined in the first ethanol solution, after being uniformly mixed, spray into mixed powder by several times on a small quantity with watering can
In end, it is sufficiently stirred for mixing；With the second ethanol solution mixed-powder uniform wet made soft material again, and soft material is made 30～
The granule of 50 mesh；
In an embodiment of the present invention, the first ethanol solution is dehydrated alcohol, and the mass concentration of the second ethanol solution is
93%～97%.
In an embodiment of the present invention, the volume of the first ethanol solution is (4mL～6mL) with the mass ratio of Mentholum: (3g
～5g)；In other embodiments of the invention, the mass ratio of the volume of the first ethanol solution and Mentholum be (4.5mL～
5.5mL): (3.5g～4.5g).
In an embodiment of the present invention, the volume ratio of the first ethanol solution and the second ethanol solution is (4～6): (8～
12)；In other embodiments of the invention, the volume ratio of the first ethanol solution and the second ethanol solution is (4.5～5.5): (9
～11).
In order to further illustrate the present invention, the metronidazole oral sticking tablets that the present invention provided below in conjunction with embodiment and
Preparation method is described in detail.
Embodiment 1
Composition of raw materials: 3g metronidazole, 7g carbomer, 7g hydroxypropyl methylcellulose, 5g betacyclodextrin, 0.5g bicarbonate
Sodium, 0.3g Mentholum, 0.1g saccharin sodium, 0.3g Pulvis Talci, 0.5g magnesium stearate.
Saccharin sodium grinds to form the saccharin sodium fine powder of 50 mesh, and metronidazole pulverizing is the metronidazole powder of 100 mesh；By saccharin sodium
After fine powder is mixed homogeneously with sodium bicarbonate, employing equal increments mode adds metronidazole powder, hypromellose, he sticks with paste by a ring again
Essence, makes the mixed-powder of 50 mesh；
Mentholum is joined in 0.4mL dehydrated alcohol, after being uniformly mixed, spray into mixed powder by several times on a small quantity with watering can
In end, it is sufficiently stirred for mixing；With the 0.98mL ethanol solution that mass concentration is 93%, mixed-powder uniform wet is made soft again
Material, and soft material is made the granule of 30 mesh；
After being mixed homogeneously with carbomer, Pulvis Talci by granule, add magnesium stearate mixing, tabletting obtains metronidazole oral cavity
Sticking tablet, the quality of every metronidazole oral sticking tablets is 39mg.
Embodiment 2
Composition of raw materials: 8g metronidazole, 10g carbomer, 15g hydroxypropyl methylcellulose, 15g betacyclodextrin, 3g bicarbonate
Sodium, 2g Mentholum, 1g saccharin sodium, 1.5g Pulvis Talci, 2.5g magnesium stearate.
Saccharin sodium grinds to form the saccharin sodium fine powder of 100 mesh, and metronidazole pulverizing is the metronidazole powder of 50 mesh；By saccharin sodium
After fine powder is mixed homogeneously with sodium bicarbonate, employing equal increments mode adds metronidazole powder, hypromellose, he sticks with paste by a ring again
Essence, makes the mixed-powder of 30 mesh；
Mentholum is joined in 2.4mL dehydrated alcohol, after being uniformly mixed, spray into mixed powder by several times on a small quantity with watering can
In end, it is sufficiently stirred for mixing；With the 5.24mL ethanol solution that mass concentration is 94%, mixed-powder uniform wet is made soft again
Material, and soft material is made the granule of 35 mesh；
After being mixed homogeneously with carbomer, Pulvis Talci by granule, add magnesium stearate mixing, tabletting obtains metronidazole oral cavity
Sticking tablet, the quality of every metronidazole oral sticking tablets is 36mg.
Embodiment 3
Composition of raw materials: 4g metronidazole, 8g carbomer, 9g hydroxypropyl methylcellulose, 8g betacyclodextrin, 1g sodium bicarbonate,
0.8g Mentholum, 0.3g saccharin sodium, 0.6g Pulvis Talci, 1g magnesium stearate.
Saccharin sodium grinds to form the saccharin sodium fine powder of 70 mesh, and metronidazole pulverizing is the metronidazole powder of 70 mesh；By saccharin sodium
After fine powder is mixed homogeneously with sodium bicarbonate, employing equal increments mode adds metronidazole powder, hypromellose, he sticks with paste by a ring again
Essence, makes the mixed-powder of 45 mesh；
Mentholum is joined in 1.03mL dehydrated alcohol, after being uniformly mixed, spray into mixing by several times on a small quantity with watering can
In powder, it is sufficiently stirred for mixing；With the 1.55mL ethanol solution that mass concentration is 96%, mixed-powder uniform wet is made again
Soft material, and soft material is made the granule of 30～50 mesh；
After being mixed homogeneously with carbomer, Pulvis Talci by granule, add magnesium stearate mixing, tabletting obtains metronidazole oral cavity
Sticking tablet, the quality of every metronidazole oral sticking tablets is 48mg.
Embodiment 4
Composition of raw materials: 6g metronidazole, 9g carbomer, 12g hydroxypropyl methylcellulose, 12g betacyclodextrin, 2g bicarbonate
Sodium, 1.5g Mentholum, 0.7g saccharin sodium, 1.2g Pulvis Talci, 2g magnesium stearate.
Saccharin sodium grinds to form the saccharin sodium fine powder of 90 mesh, and metronidazole pulverizing is the metronidazole powder of 90 mesh；By saccharin sodium
After fine powder is mixed homogeneously with sodium bicarbonate, employing equal increments mode adds metronidazole powder, hypromellose, he sticks with paste by a ring again
Essence, makes the mixed-powder of 35 mesh；
Mentholum is joined in 1.83mL dehydrated alcohol, after being uniformly mixed, spray into mixing by several times on a small quantity with watering can
In powder, it is sufficiently stirred for mixing；With the 3.66mL ethanol solution that mass concentration is 97%, mixed-powder uniform wet is made again
Soft material, and soft material is made the granule of 30～50 mesh；
After being mixed homogeneously with carbomer, Pulvis Talci by granule, add magnesium stearate mixing, tabletting obtains metronidazole oral cavity
Sticking tablet, the quality of every metronidazole oral sticking tablets is 43mg.
Embodiment 5
Composition of raw materials: 5g metronidazole, 8.3g carbomer, 11.8g hydroxypropyl methylcellulose, 11.4g betacyclodextrin, 1.2g
Sodium bicarbonate, 0.82g Mentholum, 0.42g saccharin sodium, 0.8g Pulvis Talci, 1.26g magnesium stearate.
Saccharin sodium grinds to form the saccharin sodium fine powder of 80 mesh, and metronidazole pulverizing is the metronidazole powder of 80 mesh；By saccharin sodium
After fine powder is mixed homogeneously with sodium bicarbonate, employing equal increments mode adds metronidazole powder, hypromellose, he sticks with paste by a ring again
Essence, makes the mixed-powder of 40 mesh；
Mentholum is joined in 1mL dehydrated alcohol, after being uniformly mixed, spray into mixed-powder by several times on a small quantity with watering can
In, it is sufficiently stirred for mixing；With the 2mL ethanol solution that mass concentration is 95%, mixed-powder uniform wet is made soft material again, and
Soft material is made the granule of 40 mesh；
After being mixed homogeneously with carbomer, Pulvis Talci by granule, add magnesium stearate mixing, tabletting obtains metronidazole oral cavity
Sticking tablet, the quality of first every nitre azoles oral cavity sticking tablet is 41mg.
One, safety testing:
The continuous gavage of rat 140 days given respectively by medicine embodiment 1～5 prepared by high and low two kinds of dosage, have no
Any untoward reaction and signs of toxicity, none animal dead.Gavage 140 days continuously, continues after drug withdrawal to observe 10, also has no
Rear something lost untoward reaction.To medication 140 days and RBC number, hemoglobin content, numeration of leukocyte and the classification of drug withdrawal rat on the 10th
Counting, platelet count, bleeding time and Liver and kidney function total bilirubin and electrocardio-activity all have no adverse effects.Postmortem is owned
Tested Mus result: perusal and light microscopic undertissue learn and check main organs tissue, all do not find any pathological lesion, to each dirty
Device weight in wet base all has no significant effect.Conclusion: the metronidazole oral sticking tablets long-term taking that embodiment 1～5 prepares is safe and reliable,
Nontoxic, without after effect.
Two, carrying out clinical trial as a example by metronidazole oral sticking tablets embodiment 5 obtained, result is as follows:
1, experimenter selects: select in March, 2013～certain hospital accepts for medical treatment so far oral ulcer patient 100 example, pharyngolaryngitis
Patient 100 example, patient with toothache 100 example.
2, packet design: oral ulcer patient is randomly divided into two groups, each 50 examples, it is experimental group 1 and matched group 1, patient
At the aspect such as age, the state of an illness without significant difference, there is comparability；Pharyngolaryngitis patient is randomly divided into two groups, each 50 examples, i.e. experimental group
2 and matched group 2, patient without significant difference, has comparability at the aspect such as age, the state of an illness；Patient with toothache is randomly divided into two groups, respectively
50 examples, i.e. experimental group 3 and matched group 3, patient without significant difference, has comparability at the aspect such as age, the state of an illness.Wherein experimental group
1～3 metronidazole oral sticking tabletses all using embodiment 1 preparation, matched group 1～3 all uses the good benefit metronidazole that market is conventional
Oral cavity sticking tablet.
4, curative effect judging standard
Curing: patients symptomatic disappears, body surface recovers normal；
Effective: patients symptomatic gradually alleviates or transference cure；
Invalid: to rush down symptom without taking a turn for the better；
Total effective rate=(curing number of cases+effective number of cases)/case load.
5, result is as shown in table 1
Table 1 experimental group 1～3 and the therapeutic outcome of matched group 1～3
| Case load | Cure number of cases | Effectively number of cases | Invalid number of cases | Total effective rate | |
| Experimental group 1 | 50 | 44 | 5 | 1 | 98% |
| Experimental group 2 | 50 | 43 | 5 | 2 | 96% |
| Experimental group 3 | 50 | 45 | 3 | 2 | 96% |
| Matched group 1 | 50 | 42 | 3 | 5 | 90% |
| Matched group 2 | 50 | 40 | 4 | 6 | 88% |
| Matched group 3 | 50 | 41 | 3 | 6 | 88% |
The foregoing is only presently preferred embodiments of the present invention, not in order to limit the present invention, all essences in the present invention
Within god and principle, any modification, equivalent substitution and improvement etc. made, should be included within the scope of the present invention.
Claims (6)
1. a metronidazole oral sticking tablets, it is characterised in that include the raw material of following parts by weight:
2. metronidazole oral sticking tablets as claimed in claim 1, it is characterised in that include the raw material of following parts by weight:
3. the preparation method of a metronidazole oral sticking tablets as claimed in claim 1, it is characterised in that include walking as follows
Rapid:
Saccharin sodium grinds to form the saccharin sodium fine powder of 50～100 mesh, and metronidazole pulverizing is the metronidazole powder of 50～100 mesh；Will
After described saccharin sodium fine powder is mixed homogeneously with sodium bicarbonate, add described metronidazole powder, hypromellose, he sticks with paste by a ring again
Essence, makes the mixed-powder of 30～50 mesh；
Mentholum is joined in the first ethanol solution, after being uniformly mixed, spray into described mixed powder by several times on a small quantity with watering can
In end, it is sufficiently stirred for mixing；With the second ethanol solution, described mixed-powder uniform wet is made soft material again, and soft material is made
The granule of 30～50 mesh；
After being mixed homogeneously with carbomer, Pulvis Talci by described granule, add magnesium stearate mixing, tabletting obtains metronidazole oral cavity
Sticking tablet；The weight of every described metronidazole oral sticking tablets is 36～48mg.
4. preparation method as claimed in claim 3, it is characterised in that described first ethanol solution is dehydrated alcohol, described the
The mass concentration of diethanol solution is 93%～97%.
5. preparation method as claimed in claim 3, it is characterised in that the volume of described first ethanol solution and described Mentholum
Mass ratio be (4mL～6mL): (3g～5g)；Described first ethanol solution is (4 with the volume ratio of described second ethanol solution
～6): (8～12).
6. preparation method as claimed in claim 3, it is characterised in that described metronidazole powder, described hypromellose, institute
Stating betacyclodextrin uses the mode of equal increments to join in the mixture of described saccharin sodium fine powder and described sodium bicarbonate.
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110859815A (en) * | 2019-12-05 | 2020-03-06 | 远大医药（中国）有限公司 | Metronidazole preparation and preparation method thereof |
| CN111358770A (en) * | 2020-03-25 | 2020-07-03 | 天津大学 | Method for synthesizing gel patch preparation for treating periodontitis |
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| CN111358770A (en) * | 2020-03-25 | 2020-07-03 | 天津大学 | Method for synthesizing gel patch preparation for treating periodontitis |
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