CN115697492A - 一种含有三环杂芳基的化合物的用途 - Google Patents
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- CN115697492A CN115697492A CN202280000403.9A CN202280000403A CN115697492A CN 115697492 A CN115697492 A CN 115697492A CN 202280000403 A CN202280000403 A CN 202280000403A CN 115697492 A CN115697492 A CN 115697492A
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Abstract
本申请提供化合物(I)、其光学异构体或其药学上可接受的盐在制备用于治疗JAK和SYK激酶高表达或异常激活相关疾病，包括自身免疫性疾病，如免疫介导的皮肤病，尤其是银屑病、特应性皮炎和SLE的药物中的用途。本发明所述化合物(I)、其光学异构体或其药学上可接受的盐可改善银屑病、特应性皮炎和SLE小鼠皮肤病变，缓解肾损伤，抑制免疫器官增大，降低炎症水平，抑制血清中SLE相关抗体和细胞因子的增高，且具有一定安全治疗窗，具有很好的临床应用前景。
Description
PCT国内申请，说明书已公开。
Claims (10)
- PCT国内申请，权利要求书已公开。
Applications Claiming Priority (5)
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| CN202110255275X | 2021-03-09 | ||
| CN202110255275 | 2021-03-09 | ||
| CN202110861899 | 2021-07-29 | ||
| CN2021108618996 | 2021-07-29 | ||
| PCT/CN2022/079887 WO2022188796A1 (zh) | 2021-03-09 | 2022-03-09 | 一种含有三环杂芳基的化合物的用途 |
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| CN115697492A true CN115697492A (zh) | 2023-02-03 |
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| US (1) | US20240165123A1 (zh) |
| EP (1) | EP4306172A1 (zh) |
| JP (1) | JP2024509309A (zh) |
| CN (1) | CN115697492A (zh) |
| CA (1) | CA3224094A1 (zh) |
| WO (1) | WO2022188796A1 (zh) |
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| WO2023076161A1 (en) | 2021-10-25 | 2023-05-04 | Kymera Therapeutics, Inc. | Tyk2 degraders and uses thereof |
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| WO2009136995A2 (en) * | 2008-04-16 | 2009-11-12 | Portola Pharmaceuticals, Inc. | Inhibitors of syk protein kinase |
| CA2960692C (en) * | 2008-04-16 | 2019-09-24 | Portola Pharmaceuticals, Inc. | 2,6-diamino-pyrimidin-5-yl-carboxamides as syk or jak kinase inhibitors |
| US8481541B2 (en) * | 2010-03-22 | 2013-07-09 | Hoffmann-La Roche Inc. | Pyrrolopyrazine kinase inhibitors |
| CN103003281A (zh) * | 2010-05-20 | 2013-03-27 | 弗·哈夫曼-拉罗切有限公司 | 作为JAK和SYK抑制剂的吡咯并[2，3-b]吡嗪-7-甲酰胺衍生物和它们的用途 |
| CN110734454B (zh) | 2016-12-12 | 2021-08-17 | 石药集团中奇制药技术（石家庄）有限公司 | 一类含有三环杂芳基的化合物 |
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2022
- 2022-03-09 CN CN202280000403.9A patent/CN115697492A/zh active Pending
- 2022-03-09 JP JP2023555473A patent/JP2024509309A/ja active Pending
- 2022-03-09 EP EP22766319.2A patent/EP4306172A1/en active Pending
- 2022-03-09 WO PCT/CN2022/079887 patent/WO2022188796A1/zh active Application Filing
- 2022-03-09 CA CA3224094A patent/CA3224094A1/en active Pending
- 2022-03-09 US US18/280,868 patent/US20240165123A1/en active Pending
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| Publication number | Publication date |
|---|---|
| EP4306172A1 (en) | 2024-01-17 |
| CA3224094A1 (en) | 2022-09-15 |
| US20240165123A1 (en) | 2024-05-23 |
| WO2022188796A1 (zh) | 2022-09-15 |
| JP2024509309A (ja) | 2024-02-29 |
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