CN115671243A - Traditional Chinese medicine preparation for treating hyperlipidemia and preparation method thereof - Google Patents
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Abstract
The application provides a traditional Chinese medicine preparation for treating hyperlipidemia and a preparation method thereof, and relates to the technical field of traditional Chinese medicine preparations. A traditional Chinese medicine preparation for treating hyperlipidemia comprises the following raw materials in parts by weight: 15-35 parts of prepared fleece-flower root, 20-40 parts of cassia seed, 15-35 parts of rhizoma alismatis, 15-35 parts of raw hawthorn, 5-15 parts of lotus leaf, 10-30 parts of salvia miltiorrhiza and 5-25 parts of radix curcumae. The medicines are reasonably compatible, and play a role in soothing liver-qi stagnation, nourishing spleen, tonifying qi, removing blood stasis and removing dampness. Finally, the traditional Chinese medicine composition has the effect of treating both symptoms and root causes for the hyperlipemia for organisms.
Description
Technical Field
The application relates to the technical field of traditional Chinese medicine preparations, in particular to a traditional Chinese medicine preparation for treating hyperlipidemia and a preparation method thereof.
Background
Hyperlipidemia refers to the condition of high blood lipid level of people, is a common disease and frequently occurs in middle-aged and elderly people, and is a trend of being younger and increasing in people suffering from hyperlipidemia due to the improvement of living standard and the change of living habits and dietary structures in recent years. Hyperlipidemia can directly cause diseases such as atherosclerosis, coronary heart disease, cerebral thrombosis, cerebral hemorrhage and the like which are harmful to human health, and even threatens human life in severe cases. Therefore, hyperlipidemia is not only a little high in blood lipid, but its severity is absolutely not negligible.
The plasma lipid is mainly from food, the plasma cholesterol level can be reduced by 5 to 10 percent by controlling diet, and the diet control can have certain influence on reducing blood fat, but can only be used as an auxiliary means and can not solve the fundamental problem. The effect of treating hyperlipemia by using western medicines is quick, but most of the western medicines have more adverse reactions, and the effect is too single and easily causes organic lesions such as liver injury, muscle toxicity and the like of patients. Meanwhile, chemical hypolipidemic drugs are required to be taken for a long time, blood fat is easy to rebound after drug withdrawal, the recurrence rate is relatively high, and both symptoms and root causes cannot be treated.
The traditional Chinese medicine has a history of thousands of years, and has the advantages of rich medicine sources, small adverse reaction, multiple ways, multiple targets and definite clinical treatment effect. According to the research of the theory of traditional Chinese medicine, the hyperlipidemia belongs to the deficiency of liver and kidney, spleen deficiency and phlegm dampness, and qi stagnation and blood stasis, and the traditional Chinese medicine more focuses on regulating the body after integrating medicines with different efficacies in treatment, thereby not only conforming to the physiological rule of the human body, but also achieving the effect of treating both symptoms and root causes.
Disclosure of Invention
The application aims to provide a traditional Chinese medicine preparation for treating hyperlipidemia, and the traditional Chinese medicine preparation has the effects of treating both symptoms and root causes of hyperlipidemia.
Another objective of the present application is to provide a preparation method of the Chinese medicinal preparation for treating hyperlipidemia, so as to obtain the Chinese medicinal preparation for treating hyperlipidemia.
The technical problem to be solved by the application is achieved by adopting the following technical scheme.
On one hand, the embodiment of the application provides a traditional Chinese medicine preparation for treating hyperlipidemia, which comprises the following raw materials in parts by weight: 15-35 parts of prepared fleece-flower root, 20-40 parts of cassia seed, 15-35 parts of rhizoma alismatis, 15-35 parts of raw hawthorn, 5-15 parts of lotus leaf, 10-30 parts of salvia miltiorrhiza and 5-25 parts of radix curcumae.
On the other hand, the embodiment of the application provides a preparation method of a traditional Chinese medicine preparation for treating hyperlipidemia, which comprises the following steps:
crushing the raw materials, and then mixing to obtain mixed powder;
mixing the mixed powder with water, soaking, decocting, filtering, and collecting filtrate;
adding 150-250 parts by weight of vinegar and an egg, and soaking to obtain the finished product of the traditional Chinese medicine preparation for treating hyperlipidemia.
Compared with the prior art, the embodiment of the application has at least the following advantages or beneficial effects:
the inventor believes that the hyperlipidemia belongs to the categories of phlegm dampness, turbid stagnation, obesity and the like in traditional Chinese medicine. Phlegm-dampness is caused by spleen deficiency failing to transport and transform water-dampness, failing to distribute body fluid normally, liver stagnation failing to achieve the function of qi stagnation and blood stagnation, which results in stagnation of qi and blood, and stagnation of blood and blood stasis, resulting in turbid obstruction and affecting metabolism.
Aiming at the above conditions, the traditional Chinese medicine composition needs to invigorate the spleen, replenish qi, eliminate dampness, resolve phlegm, warm and resolve water dampness, and soothe the liver and relieve depression. After creative work, the inventor selects radix polygoni multiflori preparata, semen cassiae, rhizoma alismatis, raw hawthorn, lotus leaves, radix salviae miltiorrhizae and radix curcumae to be matched, the radix polygoni multiflori preparata warms and nourishes liver and kidney, the radix polygoni multiflori preparata and the semen cassiae play the roles of soothing liver, replenishing essence, promoting blood circulation and relieving depression, the lotus leaves clear heat and dissipate blood stasis, the radix salviae miltiorrhizae activates blood and removes stasis, the radix curcumae activates blood, promotes qi circulation and relieves depression, the lotus leaves, the radix curcumae and the radix salviae are cooperated to promote and remove blood stasis, and liver blood is normal, and liver qi is dredged to eliminate liver depression; rhizoma alismatis enters bladder channels, and has the effects of promoting diuresis, eliminating dampness, eliminating turbid pathogen, reducing blood fat and warming and resolving dampness; the raw hawthorns are used for nourishing spleen and stomach, promoting qi circulation to promote digestion and promoting the health of the spleen and stomach from the source, so that the internal generation of damp-heat is avoided, and the phlegm is reduced. The medicines are reasonably compatible, and play a role in soothing liver-qi stagnation, nourishing spleen, tonifying qi, removing blood stasis and removing dampness. Finally, the traditional Chinese medicine composition has the effect of treating both symptoms and root causes for the hyperlipemia for organisms.
Detailed Description
In order to make the objects, technical solutions and advantages of the embodiments of the present application clearer, the technical solutions of the embodiments of the present application will be clearly and completely described below. The examples, in which specific conditions are not specified, were conducted under conventional conditions or conditions recommended by the manufacturer. The reagents or instruments used are not indicated by the manufacturer, and are all conventional products available commercially.
It should be noted that the embodiments and features of the embodiments in the present application may be combined with each other without conflict. The present application will be described in detail below with reference to specific examples.
Preparing fleece-flower root: bitter, sweet and astringent taste, slightly warm in nature; it enters liver, heart and kidney meridians. Tonify liver and kidney, replenish essence and blood, blacken beard and hair, and strengthen tendons and bones. Can be used for treating blood deficiency, sallow complexion, giddiness, tinnitus, early white beard and hair, soreness of waist and knees, numbness of limbs, metrorrhagia, leukorrhagia, and asthenia; hyperlipidemia.
Cassia seed: sweet, bitter, salty and slightly cold in nature; it enters liver and large intestine meridians. Has the effects of clearing heat, improving eyesight, moistening intestines and relaxing bowels. Can be used for treating conjunctival congestion, swelling and pain, photophobia, lacrimation, dim eyesight, headache, vertigo, and constipation due to intestinal dryness.
Rhizoma alismatis: sweet and light taste, cold in nature; it enters kidney and bladder meridians. Has effects of promoting diuresis, eliminating dampness, clearing heat, eliminating turbid pathogen, and reducing blood lipid. Can be used for treating dysuria, edema, abdominal distention, diarrhea, oliguria, phlegm retention, vertigo, stranguria with heat, and hyperlipidemia.
Raw hawthorn: sour and sweet in taste, slightly warm in nature; it enters spleen and stomach meridians. Has effects of resolving food stagnation, activating qi-flowing and removing blood stasis. It can be used for treating food stagnation, dysentery, abdominal pain, hernia pain, chest pain due to blood stasis, and dysmenorrhea.
Lotus leaf: bitter taste and mild nature. It enters liver, spleen and stomach meridians. Has the main effects of clearing away summer-heat, ascending the body fluid, clearing yang, dissipating blood stasis and stopping bleeding.
Red sage root: bitter taste and slightly cold nature; it enters heart, pericardium and liver meridians. Has effects in promoting blood circulation, regulating menstruation, dispelling blood stasis, relieving pain, cooling blood, removing carbuncle, relieving restlessness, and tranquilizing mind. Can be used for treating menoxenia, amenorrhea, dysmenorrhea, puerperal abdominal pain due to blood stasis, cardialgia, abdominal pain, abdominal mass, traumatic injury, rheumatism, skin sore, carbuncle, toxic swelling, fever, dysphoria, unconsciousness, palpitation, and insomnia.
Turmeric root-tuber: pungent, bitter and cold in nature; it enters liver, gallbladder and heart meridians. Has effects of promoting blood circulation, relieving pain, activating qi-flowing, resolving stagnation, clearing heart fire, cooling blood, promoting bile flow, and eliminating jaundice. Can be used for treating qi stagnation, blood stasis and pain, coma due to fever, epilepsy, phlegm retention, hematemesis, epistaxis, retrograde menstruation, hematuria, stranguria with blood, jaundice due to damp-heat in liver and gallbladder, and cholelithiasis.
Rhizoma Dioscoreae Septemlobae: bitter taste and mild nature; they enter kidney and stomach meridians. Has effects of promoting diuresis, removing turbid pathogen, dispelling pathogenic wind, and removing arthralgia. It is mainly used for treating stranguria caused by chyluria, whitish and turbid urine, rheumatic arthralgia, spermatorrhea, damp-heat sore and eczema, etc.
Bupleurum root: bitter and pungent taste, slightly cold nature; it enters liver and gallbladder meridians. Has the effects of relieving exterior syndrome, relieving fever, dispersing stagnated liver qi for relieving qi stagnation, and lifting yang qi. It is mainly used for treating exterior syndrome fever, shaoyang syndrome, liver depression and qi stagnation, qi deficiency sinking, organ prolapse, fever abatement and malaria interception.
Ligusticum wallichii: pungent taste and warm nature; it enters liver, gallbladder and pericardium meridians. Has effects of promoting blood circulation, activating qi-flowing, dispelling pathogenic wind and relieving pain. It is mainly used for treating thoracic obstruction and heart pain due to heart vessel stagnation, hypochondriac distending pain due to liver depression and qi stagnation, chest and hypochondriac pricking pain due to liver blood stagnation, traumatic injury due to blood stasis, pyocutaneous disease and swelling pain, menoxenia, amenorrhea and dysmenorrhea, puerperal blood stasis and pain, lochiorrhea, various headaches and rheumatism pain.
Hangzhou chrysanthemum: sweet and bitter in taste and cool in nature. Has effects of dispelling pathogenic wind, removing heat, improving eyesight, removing nebula, and relieving headache. It can be used for treating wind-heat syndrome of head and eye, vertigo, headache, and eye diseases.
Cornus officinalis: sour and astringent taste, slightly warm in nature. It enters liver and kidney meridians. Tonify liver and kidney, astringe essence and relieve depletion. Has effects of enhancing immunity, resisting inflammation, resisting aging, and inhibiting bacteria. In addition, it also has effects of inhibiting platelet aggregation and resisting thrombosis, and reducing blood sugar, blood lipid, tonifying heart, and resisting hemorrhagic shock.
Dried ginger: pungent taste and hot property; it enters spleen, stomach, heart and lung meridians. Has the effects of warming spleen and stomach for dispelling cold, restoring yang and dredging collaterals, and warming lung and resolving fluid retention. It can be used for treating abdominal psychroalgia, emesis, diarrhea, yang exhaustion, cough and asthma due to cold-fluid retention, and arthralgia due to cold-dampness.
Magnolia bark: bitter and pungent taste, warm in nature; it enters spleen, stomach, lung and large intestine meridians. Has the effects of eliminating dampness and phlegm, descending qi and eliminating fullness. It can be used for treating damp obstruction of middle warmer, abdominal distention, dyspepsia, abdominal distention, constipation, lung qi stagnation, phlegm retention, asthma, cough, cholera, diarrhea, and globus hystericus due to stagnation of seven emotions and phlegm-qi stagnation.
Snow mountain astragalus: sweet in flavor and warm in nature. Tonify middle-jiao and Qi, strengthen superficies and promote yang. It is commonly used for qi and blood deficiency, asthenia, spontaneous perspiration, common cold, anemia, uterine prolapse, and proctoptosis.
Dried orange peel: pungent and bitter taste, warm nature; it enters spleen and lung meridians. Has the effects of regulating qi, strengthening spleen, eliminating dampness and phlegm. It can be used for treating qi stagnation of spleen and stomach, emesis, singultus, damp phlegm, cough due to cold phlegm, and thoracic obstruction.
Eucommia ulmoides: sweet taste and warm nature; it enters liver and kidney meridians. Has effects in nourishing liver and kidney, strengthening muscle and bone, and preventing miscarriage. It is indicated for lumbago due to kidney deficiency and various kinds of lumbago, threatened abortion and habitual abortion.
B, chinese sage: sweet in flavor and neutral in nature. The functions are mainly used for tonifying deficiency, strengthening spleen, promoting blood circulation and regulating menstruation. It is used for treating amenorrhea and asthenia after illness.
Litsea cubeba: pungent and bitter with warm nature. The main treatment is dispelling wind and promoting qi circulation, strengthening spleen and promoting diuresis, and external application is detoxified. Can be used for treating abdominal distention and pain, dyspepsia, diarrhea, and sunstroke; it is used externally to treat sore and ulcer with swelling and toxin.
The embodiment of the application provides a traditional Chinese medicine preparation for treating hyperlipidemia, which comprises the following raw materials in parts by weight: 15-35 parts of prepared fleece-flower root, 20-40 parts of cassia seed, 15-35 parts of rhizoma alismatis, 15-35 parts of raw hawthorn, 5-15 parts of lotus leaf, 10-30 parts of salvia miltiorrhiza and 5-25 parts of radix curcumae. The inventor believes that the hyperlipidemia belongs to the categories of phlegm dampness, turbid stagnation, obesity and the like in traditional Chinese medicine. Phlegm-dampness is caused by spleen deficiency failing to transport and transform water-dampness, failing to distribute body fluid normally, liver stagnation failing to achieve the function of qi stagnation and blood stagnation, which results in stagnation of qi and blood, and stagnation of blood and blood stasis, resulting in turbid obstruction and affecting metabolism. Aiming at the above conditions, the traditional Chinese medicine composition needs to invigorate the spleen, replenish qi, eliminate dampness, resolve phlegm, warm and resolve water dampness, and soothe the liver and relieve depression. After creative work, the inventor selects radix polygoni multiflori preparata, semen cassiae, rhizoma alismatis, raw hawthorn, lotus leaves, radix salviae miltiorrhizae and radix curcumae to be matched, the radix polygoni multiflori preparata warms and nourishes liver and kidney, the radix polygoni multiflori preparata and the semen cassiae play the roles of soothing liver, replenishing essence, promoting blood circulation and relieving depression, the lotus leaves clear heat and dissipate blood stasis, the radix salviae miltiorrhizae activates blood and removes stasis, the radix curcumae activates blood, promotes qi circulation and relieves depression, the lotus leaves, the radix curcumae and the radix salviae are cooperated to promote and remove blood stasis, and liver blood is normal, and liver qi is dredged to eliminate liver depression; rhizoma alismatis enters bladder channels, and has the effects of promoting diuresis, eliminating dampness, eliminating turbid pathogen, reducing blood fat and warming and resolving dampness; the raw hawthorns are used for nourishing spleen and stomach, promoting qi circulation to promote digestion and promoting the health of the spleen and stomach from the source, so that the internal generation of damp-heat is avoided, and the phlegm is reduced. The medicines are reasonably compatible, and play a role in soothing liver-qi stagnation, nourishing spleen, tonifying qi, removing blood stasis and removing dampness. Finally, the traditional Chinese medicine composition has the effect of treating both symptoms and root causes for the hyperlipemia for organisms.
In some embodiments of the present application, the above traditional Chinese medicine preparation for treating hyperlipidemia further comprises the following raw materials: 5-15 parts of yam rhizome, 10-25 parts of radix bupleuri, 15-30 parts of ligusticum wallichii, 10-30 parts of chrysanthemum morifolium, 5-15 parts of cornus officinalis, 5-15 parts of dried ginger, 10-30 parts of mangnolia officinalis, 25-35 parts of radix scutellariae, 5-15 parts of litsea pungens, 10-20 parts of radix astragali, 5-15 parts of dried orange peel and 5-20 parts of eucommia bark. The yam rhizome, the dried orange peel, the plectranthus, and the litsea cubeba can cooperate with the raw hawthorns to nourish spleen and eliminate dampness, the radix bupleuri, the eucommia ulmoides, the dogwood fruit cooperate with the prepared fleece-flower root and the cassia seed to play roles of nourishing liver and relieving depression, the ligusticum wallichii cooperates with the radix salviae miltiorrhizae and the radix curcumae to activate blood and promote qi circulation, the chrysanthemum morifolium ramat dissipates heat and eliminates damp-heat, the dried ginger warms the middle-jiao to dispel cold, warms the lung to reduce phlegm, the mangnolia officinalis cooperates with the dried ginger and the yam rhizome to play roles of eliminating dampness and eliminating phlegm, and the radix astragali warms the middle-jiao to nourish qi and tonify the body. The curative effect is enhanced in many aspects, thereby enhancing the curative effect on the hyperlipemia.
In some embodiments of the present application, the traditional Chinese medicine preparation for treating hyperlipidemia comprises the following raw materials in parts by weight: 25 parts of prepared fleece-flower root, 30 parts of cassia seed, 25 parts of oriental waterplantain rhizome, 20 parts of raw hawthorn, 10 parts of lotus leaf, 20 parts of salvia miltiorrhiza, 15 parts of curcuma aromatica, 10 parts of yam rhizome, 18 parts of bupleurum, 23 parts of ligusticum wallichii, 20 parts of chrysanthemum morifolium, 10 parts of cornus officinalis, 10 parts of dried ginger, 20 parts of magnolia officinalis, 30 parts of Japanese sage herb, 10 parts of litsea cubeba, 15 parts of radix astragali, 10 parts of dried orange peel and 15 parts of eucommia bark.
The embodiment of the application also provides a preparation method of the traditional Chinese medicine preparation for treating hyperlipidemia, which comprises the following steps:
crushing the raw materials, and then mixing to obtain mixed powder;
mixing the mixed powder with water, soaking, decocting, filtering, and collecting filtrate;
adding 150-250 parts by weight of vinegar and an egg, and soaking to obtain the finished product of the traditional Chinese medicine preparation for treating hyperlipidemia. The preparation method is simple and convenient, and can produce Chinese medicinal preparation with high efficiency.
In some embodiments of the present application, the above-described materials are ground to 100-200 mesh.
In some embodiments of the present application, the weight ratio of the above-mentioned powder mixture to water is 1: (8-12).
In some embodiments of the present application, the soaking time of the above mixed powder after adding water is 30-60min, and the above decocting is carried out for 30-60min at 90-110 deg.C, and further for 1-2h at 70-90 deg.C.
In some embodiments of the present application, the soaking after adding vinegar and eggs is to soak eggs in the mixture of vinegar and filtrate for 20h, break open the eggs, and disperse the egg liquid in the mixture for 20h.
The features and properties of the present application are described in further detail below with reference to examples.
Example 1
A preparation method of a traditional Chinese medicine preparation for treating hyperlipidemia comprises the following steps:
raw materials: 15g of prepared fleece-flower root, 20g of cassia seed, 15g of rhizoma alismatis, 15g of raw hawthorn, 5g of lotus leaf, 10g of salvia miltiorrhiza and 5g of radix curcumae.
Crushing the raw materials into 100 meshes, and mixing to obtain mixed powder;
according to the following steps of 1:8, mixing the mixed powder with water according to the weight ratio, soaking for 30min, decocting at 90 ℃ for 30min, decocting at 70 ℃ for 1h, filtering, and collecting filtrate;
adding 150g of vinegar and an egg, soaking the egg in the mixed solution of the vinegar and the filtrate for 20h, breaking the egg, and dispersing the egg liquid in the mixed solution for 20h to obtain the finished product of the traditional Chinese medicine preparation for treating hyperlipidemia.
Example 2
A preparation method of a traditional Chinese medicine preparation for treating hyperlipidemia comprises the following steps:
raw materials: 25g of prepared fleece-flower root, 30g of cassia seed, 25g of rhizoma alismatis, 20g of raw hawthorn, 10g of lotus leaf, 20g of salvia miltiorrhiza and 15g of radix curcumae.
Crushing the raw materials to 150 meshes, and mixing to obtain mixed powder;
according to the following steps of 1:10, soaking for 45min, decocting at 100 ℃ for 50min, decocting at 80 ℃ for 1.5h, filtering, and collecting filtrate;
adding 200g of vinegar and an egg, soaking the egg in the mixed solution of the vinegar and the filtrate for 20h, breaking the egg, and dispersing the egg liquid in the mixed solution for 20h to obtain the finished product of the traditional Chinese medicine preparation for treating hyperlipidemia.
Example 3
A preparation method of a traditional Chinese medicine preparation for treating hyperlipidemia comprises the following steps:
raw materials: 35g of prepared fleece-flower root, 40g of cassia seed, 35g of rhizoma alismatis, 35g of raw hawthorn, 15g of lotus leaf, 30g of salvia miltiorrhiza and 25g of radix curcumae.
Crushing the raw materials to 200 meshes, and mixing to obtain mixed powder;
according to the following steps: 12, mixing the mixed powder with water, soaking for 60min, decocting at 110 ℃ for 60min, decocting at 90 ℃ for 2h, filtering, and collecting filtrate;
adding 250g of vinegar and an egg, soaking the egg in the mixed solution of the vinegar and the filtrate for 20h, breaking the egg, and dispersing the egg liquid in the mixed solution for 20h to obtain the finished product of the Chinese medicinal preparation for treating hyperlipidemia.
Example 4
A preparation method of a traditional Chinese medicine preparation for treating hyperlipidemia comprises the following steps:
raw materials: 15g of prepared fleece-flower root, 20g of cassia seed, 15g of rhizoma alismatis, 15g of raw hawthorn, 5g of lotus leaf, 10g of salvia miltiorrhiza, 5g of radix curcumae, 5g of yam rhizome, 10g of radix bupleuri, 15g of ligusticum wallichii, 10g of chrysanthemum morifolium, 5g of cornus officinalis, 5g of rhizoma zingiberis, 10g of mangnolia officinalis, 25g of radix scutellariae, 5g of litsea cubeba, 10g of radix astragali, 5g of dried orange peel and 5g of eucommia ulmoides.
Crushing the raw materials to 100 meshes, and mixing to obtain mixed powder;
according to the following steps of 1:8, mixing the mixed powder with water according to the weight ratio, soaking for 30min, decocting at 90 ℃ for 30min, decocting at 70 ℃ for 1h, filtering, and collecting filtrate;
adding 150g of vinegar and an egg, soaking the egg in the mixed solution of the vinegar and the filtrate for 20h, breaking the egg, and dispersing the egg liquid in the mixed solution for 20h to obtain the finished product of the traditional Chinese medicine preparation for treating hyperlipidemia.
Example 5
A preparation method of a traditional Chinese medicine preparation for treating hyperlipidemia comprises the following steps:
raw materials: 25g of prepared fleece-flower root, 30g of cassia seed, 25g of rhizoma alismatis, 20g of raw hawthorn, 10g of lotus leaf, 20g of salvia miltiorrhiza, 15g of radix curcumae, 10g of yam rhizome, 18g of radix bupleuri, 23g of ligusticum wallichii, 20g of chrysanthemum morifolium, 10g of cornus officinalis, 10g of rhizoma zingiberis, 20g of mangnolia officinalis, 30g of radix scutellariae, 10g of litsea cubeba, 15g of radix astragali, 10g of dried orange peel and 15g of eucommia ulmoides.
Crushing the raw materials to 150 meshes, and mixing to obtain mixed powder;
according to the following steps of 1:10, soaking for 50min, decocting at 100 ℃ for 50min, decocting at 80 ℃ for 1.5h, filtering, and collecting filtrate;
adding 200g of vinegar and an egg, soaking the egg in the mixed solution of the vinegar and the filtrate for 20h, breaking the egg, and dispersing the egg liquid in the mixed solution for 20h to obtain the finished product of the traditional Chinese medicine preparation for treating hyperlipidemia.
Example 6
A preparation method of a traditional Chinese medicine preparation for treating hyperlipidemia comprises the following steps:
raw materials: 35g of prepared fleece-flower root, 40g of cassia seed, 35g of rhizoma alismatis, 35g of raw hawthorn, 15g of lotus leaf, 30g of salvia miltiorrhiza, 25g of radix curcumae, 15g of yam rhizome, 25g of radix bupleuri, 30g of ligusticum wallichii, 30g of chrysanthemum morifolium, 15g of cornus officinalis, 15g of rhizoma zingiberis, 30g of mangnolia officinalis, 35g of radix scutellariae, 15g of litsea cubeba, 20g of radix astragali, 15g of dried orange peel and 20g of eucommia ulmoides.
Crushing the raw materials to 200 meshes, and mixing to obtain mixed powder;
according to the following steps: 12, mixing the mixed powder with water, soaking for 60min, decocting at 90-110 ℃ for 60min, decocting at 90 ℃ for 2h, filtering, and collecting filtrate;
adding 250g of vinegar and an egg, soaking the egg in the mixed solution of the vinegar and the filtrate for 20h, breaking the egg, and dispersing the egg liquid in the mixed solution for 20h to obtain the finished product of the traditional Chinese medicine preparation for treating hyperlipidemia.
Examples of the experiments
60 patients with hyperlipidemia who were admitted to the clinic were studied during the period of 6-2022 and 7-2020, and randomly divided into experimental groups and control groups, wherein the experimental groups were treated with the Chinese medicinal preparations prepared in examples 2 and 4, respectively, and the control groups were treated with Qiangli Dingxuan capsules (Jiangxi Yitao pharmaceutical Co., ltd., product number: 14001067106) 20 each group, using the guidelines (trial) for clinical study of new Chinese medicinal drugs as the diagnostic criteria. 32 of volunteers were male and 28 female; age 52.7 ± 2.5 years; the course of disease is 3.5 + -1.5 years. The experimental group was administered three times a day, 100ml each time, half an hour after each meal. The control group is administered three times a day, 5 tablets each time, half an hour after each meal. The treatment was continued for 2 months without other drugs during the treatment period, and the treatment results are shown in table 1.
Clinical evaluation criteria:
the effect is shown: fasting blood sugar is less than 7.22mmol/L, blood sugar 2h after meal is less than 10.08mmol/L, TC is less than 5.96mmol/L, and TG is less than 1.47mmol/L;
the method has the following advantages: fasting blood sugar is less than 8.33mmol/L, blood sugar 2h after meal is less than 11.1mmol/L, TC is less than 6.48mmol/L, and TG is less than 1.7mmol/L;
and (4) invalidation: the patient's condition was not improved or severe.
TABLE 1
Group of | Show effect/human | Effective/human | Invalid/human |
Example 2 | 15 | 3 | 2 |
Example 4 | 18 | 2 | 0 |
Control group | 5 | 10 | 5 |
With the combination of table 1, it can be seen that the Chinese medicinal preparation prepared by the application has a good treatment effect on hyperlipidemia.
Typical cases:
1. x certain, 55 years old, female, hyperlipemia for more than 3 years, chest distress, chest pain and dizziness symptoms, and hypertension accompanied, the Chinese medicinal preparation prepared in the embodiment 3 is selected for treatment, the Chinese medicinal preparation is taken three times a day, 100ml each time, half an hour after each meal, 1 month of continuous treatment is carried out, the symptoms are improved, and 2 months of continuous treatment is carried out, and the symptoms disappear.
2. After a certain age, 52 years old, male and male have palpitation and dizziness symptoms, and after half a year of treatment elsewhere, the symptoms are only slightly improved, the inventor selects the traditional Chinese medicine preparation prepared in the example 5 for treatment, and takes the traditional Chinese medicine preparation three times a day, 100ml each time, half an hour after each meal, and after 2 months, the symptoms disappear and are cured.
In conclusion, the inventor of the application considers that the hyperlipidemia belongs to the categories of phlegm dampness, turbid stagnation, obesity and the like in the traditional Chinese medicine. Phlegm-dampness is caused by spleen deficiency failing to transport and transform water-dampness, failing to distribute body fluid normally, liver stagnation failing to achieve the function of qi stagnation and blood stagnation, which results in stagnation of qi and blood, and stagnation of blood and blood stasis, resulting in turbid obstruction and affecting metabolism.
Aiming at the above conditions, the traditional Chinese medicine composition needs to invigorate the spleen, replenish qi, eliminate dampness, resolve phlegm, warm and resolve water dampness, and soothe the liver and relieve depression. After creative work, the inventor selects radix polygoni multiflori preparata, semen cassiae, rhizoma alismatis, raw hawthorn, lotus leaves, radix salviae miltiorrhizae and radix curcumae to be matched, the radix polygoni multiflori preparata warms and nourishes liver and kidney, the radix polygoni multiflori preparata and the semen cassiae play the roles of soothing liver, replenishing essence, promoting blood circulation and relieving depression, the lotus leaves clear heat and dissipate blood stasis, the radix salviae miltiorrhizae activates blood and removes stasis, the radix curcumae activates blood, promotes qi circulation and relieves depression, the lotus leaves, the radix curcumae and the radix salviae are cooperated to promote and remove blood stasis, and liver blood is normal, and liver qi is dredged to eliminate liver depression; rhizoma alismatis enters bladder channels, and has the effects of promoting diuresis, eliminating dampness, eliminating turbid pathogen, reducing blood fat and warming and resolving dampness; the raw hawthorns are used for nourishing spleen and stomach, promoting qi circulation to promote digestion and promoting the health of the spleen and stomach from the source, so that the internal generation of damp-heat is avoided, and the phlegm is reduced. The medicines are reasonably compatible, and play a role in soothing liver-qi stagnation, nourishing spleen, tonifying qi, removing blood stasis and removing dampness. Finally, the traditional Chinese medicine composition has the effect of treating both symptoms and root causes for the hyperlipemia for organisms.
The embodiments described above are some, but not all embodiments of the present application. The detailed description of the embodiments of the present application is not intended to limit the scope of the claimed application, but is merely representative of selected embodiments of the application. All other embodiments obtained by a person of ordinary skill in the art based on the embodiments in the present application without making any creative effort belong to the protection scope of the present application.
Claims (8)
1. The traditional Chinese medicine preparation for treating hyperlipidemia is characterized by comprising the following raw materials in parts by weight: 15-35 parts of prepared fleece-flower root, 20-40 parts of cassia seed, 15-35 parts of rhizoma alismatis, 15-35 parts of raw hawthorn, 5-15 parts of lotus leaf, 10-30 parts of salvia miltiorrhiza and 5-25 parts of radix curcumae.
2. The traditional Chinese medicine preparation for treating hyperlipidemia according to claim 1, wherein the traditional Chinese medicine preparation for treating hyperlipidemia further comprises the following raw materials: 5-15 parts of yam rhizome, 10-25 parts of radix bupleuri, 15-30 parts of ligusticum wallichii, 10-30 parts of chrysanthemum morifolium, 5-15 parts of cornus officinalis, 5-15 parts of dried ginger, 10-30 parts of mangnolia officinalis, 25-35 parts of radix scutellariae, 5-15 parts of litsea pungens, 10-20 parts of radix astragali, 5-15 parts of dried orange peel and 5-20 parts of eucommia bark.
3. The traditional Chinese medicine preparation for treating hyperlipidemia according to claim 2, which is characterized by comprising the following raw materials in parts by weight: 25 parts of prepared fleece-flower root, 30 parts of cassia seed, 25 parts of oriental waterplantain rhizome, 20 parts of raw hawthorn, 10 parts of lotus leaf, 20 parts of salvia miltiorrhiza, 15 parts of curcuma aromatica, 10 parts of yam rhizome, 18 parts of bupleurum, 23 parts of ligusticum wallichii, 20 parts of chrysanthemum morifolium, 10 parts of cornus officinalis, 10 parts of dried ginger, 20 parts of magnolia officinalis, 30 parts of Japanese sage herb, 10 parts of litsea cubeba, 15 parts of radix astragali, 10 parts of dried orange peel and 15 parts of eucommia bark.
4. The preparation method of the traditional Chinese medicine preparation for treating hyperlipidemia according to any one of claims 1-3, comprising the following steps:
crushing the raw materials, and then mixing to obtain mixed powder;
mixing the mixed powder with water, soaking, decocting, filtering, and collecting filtrate;
adding 150-250 parts by weight of vinegar and an egg, and soaking to obtain the finished product of the traditional Chinese medicine preparation for treating hyperlipidemia.
5. The preparation method of the traditional Chinese medicine preparation for treating hyperlipidemia according to claim 4, wherein the raw materials are pulverized into 100-200 meshes.
6. The preparation method of the traditional Chinese medicine preparation for treating hyperlipidemia according to claim 4, wherein the weight ratio of the mixed powder and water is 1: (8-12).
7. The preparation method of the traditional Chinese medicine preparation for treating hyperlipidemia according to claim 4, wherein the soaking time of the mixed powder after adding water is 30-60min, and the decoction is specifically that the mixed powder is decocted at 90-110 ℃ for 30-60min and then decocted at 70-90 ℃ for 1-2h.
8. The method for preparing a Chinese medicinal preparation for treating hyperlipidemia according to claim 4, wherein the soaking after adding vinegar and egg is specifically to soak egg in the mixture of vinegar and filtrate for 20h, break open egg, and disperse egg liquid in the mixture for 20h.
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