CN115671224A - Antibacterial gel for nursing private hygiene of women and preparation method thereof - Google Patents
Antibacterial gel for nursing private hygiene of women and preparation method thereof Download PDFInfo
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Abstract
The invention provides an antibacterial gel for nursing private hygiene of women and a preparation method thereof. The antibacterial gel for nursing female privacy and sanitation is prepared by the steps of raw material pretreatment, crushing, extraction, dehydration and drying, filtration, centrifugation, reduced pressure concentration, first mixing, inclusion, gel matrix preparation and second mixing. The method extracts berberine and phellodendrine in phellodendron; extracting emodin, chrysophanol, physcion and the like from sargentgloryvine stem; extracting taraxanol, caffeic acid, pectin, resin, etc. from herba Taraxaci; extracting solanine in the solanum nigrum; extracting toosendanin, ailanthone, quassin and the like from the bark of the Chinese toon root; stemonine, hodorine, stemonine, protostemonine and the like in the stemonine are extracted, the prepared antibacterial gel contains the active substances, can kill bacteria at private parts of women, has the effects of clearing heat, drying dampness, killing insects, killing lice and the like, and is a pure plant extract, safe and free of side effect.
Description
Technical Field
The invention belongs to the technical field of medicines, and particularly relates to an antibacterial gel for nursing private hygiene of women and a preparation method thereof.
Background
Because the specific physiological structure and the physique of women, in addition to various factors such as increase of competitive pressure, acceleration of working and living rhythm and the like, the mood of women is easily suppressed, the resistance of the body is reduced, originally, inactive virus and bacteria in the body begin to be activated, and the symptoms are caused, so that the morbidity of gynecological diseases of women is generally higher, the health of women is continuously threatened, wherein vaginitis is the most common gynecological diseases, and great inconvenience is brought to the life and the work of women.
Vaginitis is a disease which is usually and not cured for a long time, at present, gynecological medicines on the market are various, and the traditional bacteriostatic lotion has the defects of easy outflow, wet clothes, inconvenient use and the like. Therefore, the antibacterial gel which is convenient to use, has the functions of clearing heat, drying dampness, inhibiting bacteria, relieving itching, is safe and has no side effect and is used for nursing female privacy and sanitation has important social value.
Disclosure of Invention
Aiming at the defects in the prior art, the invention aims to provide the antibacterial gel for nursing the private hygiene of women and the preparation method thereof.
A preparation method of a bacteriostatic gel for nursing private hygiene of women comprises the following steps:
s1: pretreatment of raw materials
Selecting, cleaning and vacuum drying cortex phellodendri, sargentgloryvine stem, dandelion, black nightshade, ailanthus bark and radix stemonae which are good in quality;
s2: pulverizing
Respectively crushing dried phellodendron, sargentgloryvine stem, dandelion, black nightshade, ailanthus bark and radix stemonae, and sieving with a 20-60-mesh sieve to obtain coarse powder of phellodendron, sargentgloryvine stem, dandelion, black nightshade, ailanthus bark and radix stemonae for later use;
s3: extraction of
Respectively putting coarse powder of golden cypress, coarse powder of sargentgloryvine stem, coarse powder of dandelion, coarse powder of black nightshade, coarse powder of ailanthus bark and coarse powder of sessile stemona root into respective extraction containers, respectively adding 95% ethanol with the weight of 3-5 times of the containers, carrying out reflux extraction for three times in water bath for 30-45min each time, and combining the three extracting solutions to obtain an extracting solution of golden cypress, an extracting solution of sargentgloryvine stem, an extracting solution of dandelion, an extracting solution of black nightshade, an extracting solution of ailanthus bark and an extracting solution of sessile stemona root;
s4: dehydration and drying
Respectively adding anhydrous sodium sulfate into the phellodendron extract, the sargentgloryvine stem extract, the dandelion extract, the black nightshade extract, the toona sinensis root bark extract and the stemona root extract in the step S3 for drying;
s5: filtration
Filtering the dehydrated and dried phellodendron extract, sargentgloryvine stem extract, dandelion extract, black nightshade extract, ailanthus bark extract and stemona extract, and separating filtrate and filter residue;
s6: centrifuging, concentrating under reduced pressure
Centrifuging the obtained cortex Phellodendri filtrate, caulis Sargentodoxae filtrate, herba Taraxaci filtrate, herba Solani Nigri filtrate, cortex Ailanthi filtrate and radix Stemonae filtrate respectively, collecting supernatant, and concentrating the supernatant under reduced pressure to obtain cortex Phellodendri concentrate, caulis Sargentodoxae concentrate, herba Taraxaci concentrate, herba Solani Nigri concentrate, cortex Ailanthi concentrate and radix Stemonae concentrate;
s7: first mixing
Uniformly mixing 4-12 parts of the phellodendron concentrated solution obtained in the step S6, 2-5 parts of sargentgloryvine stem concentrated solution, 2-5 parts of dandelion concentrated solution, 8-15 parts of black nightshade concentrated solution, 2-4 parts of ailanthus bark concentrated solution and 5-10 parts of radix stemonae concentrated solution to obtain mixed solution A;
s8: is made up of
Clathrating the mixed solution A with beta-cyclodextrin to obtain a clathrate B;
s9: preparation of gel matrix
Mixing 3-7 parts of carbomer, 10-15 parts of carboxymethyl cellulose, 10-25 parts of glycerol, 1-3 parts of triethanolamine and 5-15 parts of propylene glycol in parts by weight to obtain a gel matrix;
s10: second mixing
And (2) dissolving 2-5 parts of borneol in 2-3 times of glycerol by weight of the borneol to prepare a borneol solution, adding 8-15 parts of the inclusion compound B and 5-8 parts of sericin in the step S8 into the borneol solution, uniformly stirring to obtain a mixed solution C, adding the mixed solution C into the gel matrix prepared in the step S9, stirring for 1-2 hours, and performing high-pressure homogenization treatment to obtain the antibacterial gel for nursing private hygiene of women.
Further, in the filtering process in the step S5, the solution is filtered through micropores, the filtering mesh number is 160-200 meshes, and the filtering pressure is 0.5-0.8MPa.
Further, the step S6 further comprises respectively concentrating the phellodendron bark supernatant, the sargentgloryvine stem supernatant, the dandelion herb supernatant, the black nightshade supernatant, the ailanthus bark supernatant and the stemona root supernatant under reduced pressure until the concentration is 12% -25%.
Further, the inclusion in step S8 specifically includes the following steps:
s8.1: adding 20-40 parts of beta-cyclodextrin into water at the temperature of 50-80 ℃, and maintaining the temperature at 50-80 ℃ until the beta-cyclodextrin is saturated in the water to prepare a solvent I;
s8.2: adding 10-15 parts of the mixed solution A obtained in the step S7 into the solvent I, and uniformly stirring to prepare a solvent II;
s8.3: carrying out ultrasonic treatment on the solvent II, cooling and standing the solvent II, and then filtering the solvent II to obtain a wet product of beta-cyclodextrin including the mixed solution A;
s8.4: and (3) adding the wet product into absolute ethyl alcohol for washing and drying to obtain the inclusion compound of the extracts of the phellodendron, the sargentgloryvine stem, the dandelion, the black nightshade, the ailanthus altissima root bark and the radix stemonae.
Further, the stirring in the step S8.2 is divided into two steps, wherein in the first step, after the mixed solution A is added, the liquid is required to be heated to 50-65 ℃, the mixed solution A is stirred at a low speed for 35-60min to be fully included by the beta-cyclodextrin, and in the second step, after 2-5 parts of the dispersing agent is added, the temperature is continuously kept to 50-65 ℃, the mixed solution A is stirred at a high speed for 15-35min to be uniformly distributed in the solution, wherein the mixed solution A is included by the beta-cyclodextrin.
Further, the dispersant in the step S8.2 is formed by mixing polyethylene glycol 200 and polyethylene glycol 400 according to the weight ratio of 3-5:1.
Further, in the step S8.3, the temperature of the solvent II is reduced to 15-20 ℃, and the mixture is kept stand for 1.5-3h.
Further, the preparing of the gel matrix in the step S9 specifically includes the steps of:
s9.1: taking 3-7 parts of carbomer, placing in distilled water for full swelling, and adjusting pH to 6-7 with sodium hydroxide solution to obtain carbomer solution;
s9.2: dissolving 10-15 parts of carboxymethyl cellulose in hot water at 50-85 ℃ fully, adding 10-25 parts of glycerol, 1-3 parts of triethanolamine and 5-15 parts of propylene glycol, and stirring uniformly to prepare a carboxymethyl cellulose solution;
s9.3: mixing the prepared carbomer solution and carboxymethyl cellulose solution to obtain gel matrix.
Further, the conditions of the high-pressure homogenization treatment in the step S10 are 40-60MPa, and the homogenization is carried out for 2-3 times, 15-30min each time.
Compared with the prior art, the invention has the advantages and beneficial effects that:
1. the antibacterial gel for nursing private hygiene of women is prepared by extracting berberine, phellodendrine, volatile oil, phellodendron ketone and the like from phellodendron; extracting emodin, chrysophanol, physcion and the like from sargentgloryvine stem; extracting taraxanol, taraxacum picrin, caffeic acid, pectin, resin, etc. from herba Taraxaci; extracting solanine in the solanum nigrum; extracting toosendanin, ailanthone, quassin, ailanthus bilobalide, oxalic acid and the like from the toona sinensis root bark; stemonine, hodorine, stemonine, protostemonine and the like in the stemonine are extracted, the prepared antibacterial gel contains the active substances, can sterilize bacteria at private parts of women, has the effects of clearing heat, drying dampness, killing insects, killing lice and the like, and is a pure plant extract, safe and free of side effect.
2. According to the antibacterial gel for nursing private hygiene of women, beta-cyclodextrin is adopted to perform inclusion on the extracts of phellodendron, sargentgloryvine stem, dandelion, black nightshade, ailanthus bark and radix stemonae, so that the solubility and the dissolution rate of the prepared antibacterial gel are remarkably increased, and the effect of treating gynecological inflammation is remarkably improved.
3. The antibacterial gel for nursing private hygiene of women is prepared by a coprecipitation technology to precipitate beta-cyclodextrin included by extracts of phellodendron amurense, sargentgloryvine stem, dandelion, black nightshade, ailanthus altissima root bark and radix stemonae, and the beta-cyclodextrin included by the extracts is further precipitated by cooling, so that the inclusion compound is pure beta-cyclodextrin included by the extracts, and the purity of the product is improved.
4. The antibacterial gel for nursing female private hygiene prepared by the invention has the advantages of difficult drug resistance, convenient use, easy absorption through skin, good spreadability and the like by adopting the Chinese herbal medicine formula, has relatively simple preparation process and small limitation of medicinal materials, and is suitable for nursing female private hygiene.
Drawings
Fig. 1 is a flow chart of a preparation method of a bacteriostatic gel for nursing private hygiene of women, which is adopted in the embodiment of the invention.
Fig. 2 is a diagram of the ratio of the traditional Chinese medicinal materials in the bacteriostatic gel for nursing private hygiene of women adopted by the embodiment of the invention.
Detailed Description
The present invention will be further described with reference to specific embodiments for making the objects, technical solutions and advantages of the present invention more apparent, but the present invention is not limited to these examples. It should be noted that, without conflict, any combination between the embodiments or technical features described below may form a new embodiment. In the invention, all parts and percentages are mass units, and the adopted equipment, raw materials and the like can be purchased from the market or are commonly used in the field. The methods in the following examples are conventional in the art unless otherwise specified.
The present invention will be described in further detail with reference to specific examples.
Example 1
A preparation method of antibacterial gel for caring private hygiene of female comprises the following steps as shown in figure 1 and figure 2:
s1: pretreatment of raw materials
Selecting, cleaning and vacuum drying cortex phellodendri, sargentgloryvine stem, dandelion, black nightshade, ailanthus bark and radix stemonae which are good in quality;
s2: pulverizing
Respectively crushing dried phellodendron, sargentgloryvine stem, dandelion, black nightshade, ailanthus bark and radix stemonae, and sieving with a 20-60-mesh sieve to obtain coarse powder of phellodendron, sargentgloryvine stem, dandelion, black nightshade, ailanthus bark and radix stemonae for later use;
s3: extraction of
Respectively putting coarse powder of golden cypress, coarse powder of sargentgloryvine stem, coarse powder of dandelion, coarse powder of black nightshade, coarse powder of ailanthus bark and coarse powder of sessile stemona root into respective extraction containers, respectively adding 95% ethanol with the weight of 5 times into the containers, carrying out reflux extraction for three times in water bath for 45min each time, and combining the three extracting solutions to obtain an golden cypress extracting solution, a sargentgloryvine stem extracting solution, a dandelion extracting solution, a black nightshade extracting solution, an ailanthus bark extracting solution and a sessile stemona extracting solution;
s4: dewatering and drying
Respectively adding anhydrous sodium sulfate into the phellodendron extract, the sargentgloryvine stem extract, the dandelion extract, the black nightshade extract, the toona sinensis root bark extract and the stemona root extract in the step S3 for drying;
s5: filtration
Performing microporous filtration on the dehydrated and dried phellodendron extract, sargentgloryvine stem extract, dandelion extract, black nightshade extract, ailanthus bark extract and radix stemonae extract to remove impurities in the extract, wherein the filtration mesh number is 200 meshes, and the filtration pressure is 0.6MPa, and separating filtrate and filter residue;
s6: centrifuging, concentrating under reduced pressure
Respectively centrifuging the obtained phellodendron filtrate, sargentgloryvine stem filtrate, dandelion filtrate, black nightshade filtrate, ailanthus bark filtrate and radix stemonae filtrate, taking supernatant, concentrating the supernatant under reduced pressure until the concentration is 25%, and obtaining phellodendron concentrated solution, sargentgloryvine stem concentrated solution, dandelion concentrated solution, black nightshade concentrated solution, ailanthus bark concentrated solution and radix stemonae concentrated solution;
s7: first mixing
Taking 8 parts of the phellodendron amurense concentrated solution obtained in the step S6, 3 parts of sargentgloryvine stem concentrated solution, 2 parts of dandelion concentrated solution, 10 parts of black nightshade concentrated solution, 2 parts of ailanthus altissima root bark concentrated solution and 6 parts of radix stemonae concentrated solution, and uniformly mixing to obtain mixed solution A;
s8: is made up of
Adding 30 parts of beta-cyclodextrin into 55 ℃ water, keeping the temperature at 55 ℃ until the beta-cyclodextrin is saturated in the water to prepare a solvent I, adding 15 parts of the mixed solution A obtained in the step S7 into the solvent I, heating the liquid to 65 ℃, stirring at a low speed for 50min to fully include the mixed solution A by the beta-cyclodextrin, adding 3 parts of a dispersing agent, mixing the dispersing agent with polyethylene glycol 200 and polyethylene glycol 400 according to a weight ratio of 4:1, continuously preserving the temperature to 65 ℃, stirring at a high speed for 25min to uniformly distribute the mixed solution A included by the beta-cyclodextrin into the solution to obtain a solvent II, carrying out ultrasonic treatment on the solvent II, cooling the solvent II to 20 ℃, standing for 3h, filtering the solvent II to obtain a wet product including the beta-cyclodextrin of the mixed solution A, adding the wet product into absolute ethyl alcohol to wash and dry the clathrate B of the extracts of phellodendron, sargentgloryvine stem, dandelion, black nightshade, ailanthus altissima sinensis root bark and stemona sessilifolia;
s9: preparation of the gel matrix
Taking 6 parts of carbomer, fully swelling in distilled water, adjusting the pH value to 6.8 by using a sodium hydroxide solution to prepare a carbomer solution, fully dissolving 12 parts of carboxymethyl cellulose in 75 ℃ hot water, adding 15 parts of glycerol, 2 parts of triethanolamine and 8 parts of propylene glycol, uniformly stirring to prepare a carboxymethyl cellulose solution, and uniformly mixing the prepared carbomer solution and the carboxymethyl cellulose solution to prepare a gel matrix;
s10: second mixing
Dissolving 3 parts of borneol in 3 times of glycerol by weight of borneol to prepare a borneol solution, adding 12 parts of the clathrate B and 5 parts of sericin in the step S8 into the borneol solution, uniformly stirring to obtain a mixed solution C, adding the mixed solution C into the gel matrix prepared in the step S9, stirring for 1.5h, and then carrying out high-pressure homogenization treatment under the condition of 60MPa for 3 times of homogenization for 20min each time to obtain the bacteriostatic gel for nursing the private hygiene of women.
Example 2
A preparation method of bacteriostatic gel for nursing private hygiene of women is shown in figures 1 and 2, and comprises the following steps:
s1: pretreatment of raw materials
Selecting, cleaning and vacuum drying cortex phellodendri, sargentgloryvine stem, dandelion, black nightshade, ailanthus bark and radix stemonae which are good in quality;
s2: pulverizing
Respectively crushing dried phellodendron, sargentgloryvine stem, dandelion, black nightshade, ailanthus bark and radix stemonae, and sieving with a 20-60-mesh sieve to obtain coarse powder of phellodendron, sargentgloryvine stem, dandelion, black nightshade, ailanthus bark and radix stemonae for later use;
s3: extraction of
Respectively putting coarse powder of golden cypress, coarse powder of sargentgloryvine stem, coarse powder of dandelion, coarse powder of black nightshade, coarse powder of ailanthus bark and coarse powder of sessile stemona root into respective extraction containers, respectively adding 95% ethanol with the weight of 5 times into the containers, carrying out reflux extraction for three times in water bath for 45min each time, and combining the three extracting solutions to obtain an golden cypress extracting solution, a sargentgloryvine stem extracting solution, a dandelion extracting solution, a black nightshade extracting solution, an ailanthus bark extracting solution and a sessile stemona extracting solution;
s4: dehydration and drying
Respectively adding anhydrous sodium sulfate into the phellodendron extract, the sargentgloryvine stem extract, the dandelion extract, the black nightshade extract, the toona sinensis root bark extract and the stemona root extract in the step S3 for drying;
s5: filtration
Performing microporous filtration on the dehydrated and dried phellodendron extract, sargentgloryvine stem extract, dandelion extract, black nightshade extract, ailanthus bark extract and radix stemonae extract to remove impurities in the extract, wherein the filtration mesh number is 200 meshes, and the filtration pressure is 0.6MPa, and separating filtrate and filter residue;
s6: centrifuging, concentrating under reduced pressure
Respectively centrifuging the obtained phellodendron filtrate, sargentgloryvine stem filtrate, dandelion filtrate, black nightshade filtrate, ailanthus bark filtrate and radix stemonae filtrate, taking supernatant, concentrating the supernatant under reduced pressure until the concentration is 25%, and obtaining phellodendron concentrated solution, sargentgloryvine stem concentrated solution, dandelion concentrated solution, black nightshade concentrated solution, ailanthus bark concentrated solution and radix stemonae concentrated solution;
s7: first mixing
Uniformly mixing 10 parts of the phellodendron amurense concentrated solution obtained in the step S6, 4 parts of sargentgloryvine stem concentrated solution, 3 parts of dandelion concentrated solution, 8 parts of black nightshade concentrated solution, 3 parts of ailanthus altissima root bark concentrated solution and 8 parts of radix stemonae concentrated solution to obtain mixed solution A;
s8: including
Adding 30 parts of beta-cyclodextrin into 55 ℃ water, keeping the temperature at 55 ℃ until the beta-cyclodextrin is saturated in the water to prepare a solvent I, adding 15 parts of the mixed solution A obtained in the step S7 into the solvent I, heating the liquid to 65 ℃, stirring at a low speed for 50min to fully include the mixed solution A by the beta-cyclodextrin, adding 3 parts of a dispersing agent, mixing the dispersing agent with polyethylene glycol 200 and polyethylene glycol 400 according to a weight ratio of 4:1, continuously preserving the temperature to 65 ℃, stirring at a high speed for 25min to uniformly distribute the mixed solution A included by the beta-cyclodextrin into the solution to obtain a solvent II, carrying out ultrasonic treatment on the solvent II, cooling the solvent II to 20 ℃, standing for 3h, filtering the solvent II to obtain a wet product including the beta-cyclodextrin of the mixed solution A, adding the wet product into absolute ethyl alcohol to wash and dry the clathrate B of the extracts of phellodendron, sargentgloryvine stem, dandelion, black nightshade, ailanthus altissima sinensis root bark and stemona sessilifolia;
s9: preparation of gel matrix
Taking 6 parts of carbomer, fully swelling in distilled water, adjusting the pH value to 6.8 by using a sodium hydroxide solution to prepare a carbomer solution, fully dissolving 12 parts of carboxymethyl cellulose in 75 ℃ hot water, adding 15 parts of glycerol, 2 parts of triethanolamine and 8 parts of propylene glycol, uniformly stirring to prepare a carboxymethyl cellulose solution, and uniformly mixing the prepared carbomer solution and the carboxymethyl cellulose solution to prepare a gel matrix;
s10: second mixing
Dissolving 3 parts of borneol in 3 times of glycerol by weight of borneol to prepare a borneol solution, adding 12 parts of the clathrate B and 5 parts of sericin in the step S8 into the borneol solution, uniformly stirring to obtain a mixed solution C, adding the mixed solution C into the gel matrix prepared in the step S9, stirring for 1.5h, and then carrying out high-pressure homogenization treatment under the condition of 60MPa for 3 times of homogenization for 20min each time to obtain the bacteriostatic gel for nursing the private hygiene of women.
Example 3
A preparation method of antibacterial gel for caring private hygiene of female comprises the following steps as shown in figure 1 and figure 2:
s1: pretreatment of raw materials
Selecting, cleaning and vacuum-drying cortex phellodendri, sargentgloryvine stem, dandelion, black nightshade, ailanthus bark and radix stemonae which are good in quality;
s2: pulverizing
Respectively crushing dried phellodendron, sargentgloryvine stem, dandelion, black nightshade, ailanthus bark and radix stemonae, and sieving with a 20-60-mesh sieve to obtain coarse powder of phellodendron, sargentgloryvine stem, dandelion, black nightshade, ailanthus bark and radix stemonae for later use;
s3: extraction of
Respectively putting coarse powder of golden cypress, coarse powder of sargentgloryvine stem, coarse powder of dandelion, coarse powder of black nightshade, coarse powder of ailanthus bark and coarse powder of sessile stemona root into respective extraction containers, respectively adding 95% ethanol with the weight of 5 times into the containers, carrying out reflux extraction for three times in water bath for 45min each time, and combining the three extracting solutions to obtain an golden cypress extracting solution, a sargentgloryvine stem extracting solution, a dandelion extracting solution, a black nightshade extracting solution, an ailanthus bark extracting solution and a sessile stemona extracting solution;
s4: dehydration and drying
Respectively adding anhydrous sodium sulfate into the phellodendron extract, the sargentgloryvine stem extract, the dandelion extract, the black nightshade extract, the toona sinensis root bark extract and the stemona root extract in the step S3 for drying;
s5: filtration
Performing microporous filtration on the dehydrated and dried phellodendron extract, sargentgloryvine stem extract, dandelion extract, black nightshade extract, ailanthus bark extract and radix stemonae extract to remove impurities in the extract, wherein the filtration mesh number is 200 meshes, and the filtration pressure is 0.6MPa, and separating filtrate and filter residue;
s6: centrifuging, concentrating under reduced pressure
Respectively centrifuging the obtained phellodendron filtrate, sargentgloryvine stem filtrate, dandelion filtrate, black nightshade filtrate, ailanthus bark filtrate and radix stemonae filtrate, taking supernatant, concentrating the supernatant under reduced pressure until the concentration is 25%, and obtaining phellodendron concentrated solution, sargentgloryvine stem concentrated solution, dandelion concentrated solution, black nightshade concentrated solution, ailanthus bark concentrated solution and radix stemonae concentrated solution;
s7: first mixing
Uniformly mixing 12 parts of the phellodendron concentrated solution obtained in the step S6, 3 parts of sargentgloryvine stem concentrated solution, 5 parts of dandelion concentrated solution, 12 parts of black nightshade concentrated solution, 2 parts of ailanthus bark concentrated solution and 10 parts of radix stemonae concentrated solution to obtain mixed solution A;
s8: including
Adding 30 parts of beta-cyclodextrin into 55 ℃ water, keeping the temperature at 55 ℃ until the beta-cyclodextrin is saturated in the water to prepare a solvent I, adding 15 parts of the mixed solution A obtained in the step S7 into the solvent I, heating the liquid to 65 ℃, stirring at a low speed for 50min to fully include the mixed solution A by the beta-cyclodextrin, adding 3 parts of a dispersing agent, mixing the dispersing agent with polyethylene glycol 200 and polyethylene glycol 400 according to a weight ratio of 4:1, continuously preserving the temperature to 65 ℃, stirring at a high speed for 25min to uniformly distribute the mixed solution A included by the beta-cyclodextrin into the solution to obtain a solvent II, carrying out ultrasonic treatment on the solvent II, cooling the solvent II to 20 ℃, standing for 3h, filtering the solvent II to obtain a wet product including the beta-cyclodextrin of the mixed solution A, adding the wet product into absolute ethyl alcohol to wash and dry the clathrate B of the extracts of phellodendron, sargentgloryvine stem, dandelion, black nightshade, ailanthus altissima sinensis root bark and stemona sessilifolia;
s9: preparation of gel matrix
Taking 6 parts of carbomer, fully swelling in distilled water, adjusting the pH value to 6.8 by using a sodium hydroxide solution to prepare a carbomer solution, fully dissolving 12 parts of carboxymethyl cellulose in 75 ℃ hot water, adding 15 parts of glycerol, 2 parts of triethanolamine and 8 parts of propylene glycol, uniformly stirring to prepare a carboxymethyl cellulose solution, and uniformly mixing the prepared carbomer solution and the carboxymethyl cellulose solution to prepare a gel matrix;
s10: second mixing
Taking 3 parts of borneol, adding glycerol which is 3 times of the weight of the borneol for dissolving to prepare borneol solution, adding 12 parts of inclusion compound B and 5 parts of sericin in the step S8 into the borneol solution, uniformly stirring to obtain mixed solution C, adding the mixed solution C into the gel matrix prepared in the step S9, stirring for 1.5h, and then carrying out high-pressure homogenization treatment under the condition of 60MPa for 3 times of homogenization, wherein each time is 20min, so as to obtain the bacteriostatic gel for nursing private hygiene of women.
The foregoing embodiments are merely illustrative of the principles and utilities of the present invention and are not intended to limit the invention. Any person skilled in the art can modify or change the above-mentioned embodiments without departing from the spirit and scope of the present invention. Accordingly, it is intended that all equivalent modifications or changes which can be made by those skilled in the art without departing from the spirit and technical spirit of the present invention be covered by the claims of the present invention.
Claims (9)
1. A preparation method of antibacterial gel for nursing private hygiene of women is characterized by comprising the following steps:
s1: pretreatment of raw materials
Selecting, cleaning and vacuum drying cortex phellodendri, sargentgloryvine stem, dandelion, black nightshade, ailanthus bark and radix stemonae which are good in quality;
s2: pulverizing
Respectively crushing dried phellodendron, sargentgloryvine stem, dandelion, black nightshade, ailanthus bark and radix stemonae, and sieving with a 20-60-mesh sieve to obtain coarse powder of phellodendron, sargentgloryvine stem, dandelion, black nightshade, ailanthus bark and radix stemonae for later use;
s3: extraction of
Respectively putting coarse powder of golden cypress, coarse powder of sargentgloryvine stem, coarse powder of dandelion, coarse powder of black nightshade, coarse powder of ailanthus bark and coarse powder of sessile stemona root into respective extraction containers, respectively adding 95% ethanol with the weight of 3-5 times of the containers, carrying out reflux extraction for three times in water bath for 30-45min each time, and combining the three extracting solutions to obtain an extracting solution of golden cypress, an extracting solution of sargentgloryvine stem, an extracting solution of dandelion, an extracting solution of black nightshade, an extracting solution of ailanthus bark and an extracting solution of sessile stemona root;
s4: dehydration and drying
Respectively adding anhydrous sodium sulfate into the phellodendron extract, the sargentgloryvine stem extract, the dandelion extract, the black nightshade extract, the toona sinensis root bark extract and the stemona root extract in the step S3 for drying;
s5: filtration
Filtering the dehydrated and dried phellodendron extract, sargentgloryvine stem extract, dandelion extract, black nightshade extract, ailanthus bark extract and stemona extract, and separating filtrate and filter residue;
s6: centrifuging, concentrating under reduced pressure
Centrifuging the obtained cortex Phellodendri filtrate, caulis Sargentodoxae filtrate, herba Taraxaci filtrate, herba Solani Nigri filtrate, cortex Ailanthi filtrate and radix Stemonae filtrate respectively, collecting supernatant, and concentrating the supernatant under reduced pressure to obtain cortex Phellodendri concentrate, caulis Sargentodoxae concentrate, herba Taraxaci concentrate, herba Solani Nigri concentrate, cortex Ailanthi concentrate and radix Stemonae concentrate;
s7: first mixing
Uniformly mixing 4-12 parts of the phellodendron concentrated solution obtained in the step S6, 2-5 parts of sargentgloryvine stem concentrated solution, 2-5 parts of dandelion concentrated solution, 8-15 parts of black nightshade concentrated solution, 2-4 parts of ailanthus bark concentrated solution and 5-10 parts of radix stemonae concentrated solution to obtain mixed solution A;
s8: including
Clathrating the mixed solution A with beta-cyclodextrin to obtain a clathrate B;
s9: preparation of the gel matrix
Mixing 3-7 parts of carbomer, 10-15 parts of carboxymethyl cellulose, 10-25 parts of glycerol, 1-3 parts of triethanolamine and 5-15 parts of propylene glycol according to parts by weight to prepare a gel matrix;
s10: second mixing
And (2) dissolving 2-5 parts of borneol in 2-3 times of glycerol by weight of the borneol to prepare a borneol solution, adding 8-15 parts of the inclusion compound B and 5-8 parts of sericin in the step S8 into the borneol solution, uniformly stirring to obtain a mixed solution C, adding the mixed solution C into the gel matrix prepared in the step S9, stirring for 1-2 hours, and performing high-pressure homogenization treatment to obtain the antibacterial gel for nursing private hygiene of women.
2. The method for preparing a bacteriostatic gel for nursing the private hygiene of women according to claim 1, wherein in the filtering process of the step S5, the solution is filtered through micropores, the filtering mesh number is 160-200 meshes, and the filtering pressure is 0.5-0.8MPa.
3. The method for preparing a bacteriostatic gel for nursing privacy and hygiene of women as claimed in claim 1, wherein said step S6 further comprises concentrating the supernatant of phellodendron amurense, the supernatant of sargentgloryvine stem, the supernatant of dandelion, the supernatant of black nightshade, the supernatant of ailanthus altissima bark and the supernatant of stemona root under reduced pressure respectively until the concentration is 12% -25%.
4. The method for preparing the bacteriostatic gel for nursing the private hygiene of women according to claim 1, wherein the inclusion in the step S8 specifically comprises the following steps:
s8.1: adding 20-40 parts of beta-cyclodextrin into 50-80 ℃ water, and maintaining the temperature at 50-80 ℃ until the beta-cyclodextrin is saturated in the water to prepare a solvent I;
s8.2: adding 10-15 parts of the mixed solution A obtained in the step S7 into the solvent I, and uniformly stirring to prepare a solvent II;
s8.3: carrying out ultrasonic treatment on the solvent II, cooling and standing the solvent II, and then filtering the solvent II to obtain a wet product of beta-cyclodextrin including the mixed solution A;
s8.4: and (3) adding the wet product into absolute ethyl alcohol for washing and drying to obtain the inclusion compound of the extracts of the phellodendron, the sargentgloryvine stem, the dandelion, the black nightshade, the ailanthus altissima root bark and the radix stemonae.
5. The method as claimed in claim 4, wherein the stirring in step S8.2 is divided into two steps, the first step is to heat the mixed solution A to 50-65 ℃ and stir at low speed for 35-60min, and the second step is to keep the temperature to 50-65 ℃ and stir at high speed for 15-35min after 2-5 parts of the dispersant is added.
6. The method for preparing bacteriostatic gel for nursing the private health of women as claimed in claim 4, wherein the dispersant in the step S8.2 is formed by mixing polyethylene glycol 200 and polyethylene glycol 400 according to the weight ratio of 3-5:1.
7. The method for preparing bacteriostatic gel for nursing private hygiene of women according to claim 4, wherein in said step S8.3, solvent II is cooled to 15-20 ℃ and kept standing for 1.5-3h.
8. The method for preparing a bacteriostatic gel for nursing private hygiene of women according to claim 1, wherein said preparing the gel matrix in step S9 specifically comprises the following steps:
s9.1: taking 3-7 parts of carbomer, placing in distilled water for full swelling, and adjusting pH to 6-7 with sodium hydroxide solution to obtain carbomer solution;
s9.2: dissolving 10-15 parts of carboxymethyl cellulose in hot water at 50-85 ℃ fully, adding 10-25 parts of glycerol, 1-3 parts of triethanolamine and 5-15 parts of propylene glycol, and stirring uniformly to prepare a carboxymethyl cellulose solution;
s9.3: mixing the prepared carbomer solution and carboxymethyl cellulose solution to obtain gel matrix.
9. The method for preparing bacteriostatic gel for nursing the private hygiene of women according to claim 1, wherein the condition of high pressure homogenization treatment in step S10 is 40-60MPa, and the homogenization is performed for 2-3 times, each time for 15-30min.
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| CN1660353A (en) * | 2005-01-14 | 2005-08-31 | 北京乾露春科技有限公司 | Gel of Chinese traditional medicine for treating cervicitis, colpitis and preparing method |
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| CN1660353A (en) * | 2005-01-14 | 2005-08-31 | 北京乾露春科技有限公司 | Gel of Chinese traditional medicine for treating cervicitis, colpitis and preparing method |
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