CN109568446A - A kind of anti-inflammatory antibacterial external application decontamination drug and preparation method thereof of gynaecology - Google Patents
A kind of anti-inflammatory antibacterial external application decontamination drug and preparation method thereof of gynaecology Download PDFInfo
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Abstract
The present invention relates to technical field of Chinese medicine, and in particular to a kind of anti-inflammatory antibacterial external application decontamination drug and preparation method thereof of gynaecology.The product is mainly prepared from the following materials: tender folium artemisiae argyi, green tea, kuh-seng, Cortex Phellodendri, mulberry leaf, Blumea balsamifera.Using tender folium artemisiae argyi, green tea as monarch drug in a prescription；Kuh-seng, Cortex Phellodendri are ministerial drug；Mulberry leaf, Blumea balsamifera are adjuvant.Anti-inflammatory antibacterial with clearing heat and detoxicating, clearing damp is dispelled turbid smelly antipruritic effect of dispelling, at the same to vagina because caused by inflammation hyperemia or mucosa injury play the role of promoting to restore.For women vaginitis, leukorrhea amount is more, and color Huang dirty smelly or pruritus vulvue or lochia are slowly not clean, and with hypogastric pain etc..The present invention selects High Pressure Difference, and fluid broken wall+continuous gradient molecule sieving+low temperature is concentrated and dried the combination of the molecules abstraction techniques such as crystallization+near infrared spectrum online process analysis procedure analysis repeatedly, the harmful and invalid components such as heavy metal, agriculture is residual, change is residual, impurity are screened out to greatest extent, and are efficiently kept completely separate extraction active constituent.
Description
Technical field
The present invention relates to technical field of Chinese medicine, and in particular to a kind of anti-inflammatory antibacterial external application of the skin of women special physiological phase
Decontamination drug and preparation method thereof.
Background technique
The more than Producing reason of lochia may be that uterus restores incomplete, and intrauterine may remain placenta, fetal membrane, or
Person's puerperal infection causes endometritis, myometritis etc., and sinicism is confined in childbirth for thousands of years, clear generally for skin
Clean there are taboos, such as are unable to bathing or cannot use unboiled water bathing etc., in order to avoid postpartum because bacterium infection causes
Colpitis and lochia it is slowly not clean, there are also the symptoms such as puerperal perspiration is unbroken, it usually needs using the water for being rich in Chinese medicinal ingredients
Decocting liquid cleans skin, to have the function that antibacterial anti-inflammatory；In addition, the special physiologicals period such as woman menstruation and climacteric can divide because in
There are dry skin itch, skin eczema and the lochia slowly symptoms such as not clean in the problems such as secreting, logical in order to alleviate these symptoms
The cleaning of skin often can be also carried out using some lotion products.
Although also occur on the market now it is some for women special physiological period or postpartum antibacterial anti-inflammatory, alleviate pain
The external wash liquid product of the symptoms such as pain, but these tcm product one side effects are relatively simple, such as most Chinese medicinal lotion produces
Product can only generate certain antibacterial and anti-inflammation functions, have some Chinese medicinal lotion products to be only intended to significantly alleviate postpartum or special life
The symptoms such as reason period abdominal pain lack the lotion product with multiple comprehensive health-care effect；On the other hand, existing Chinese medicine external is washed
Liquid product exist formula is excessively complicated, chemical assistant content is higher, technology content is lower, quality matte, active constituent are indefinite,
Impurity composition is higher, sanitary standard is lower, security quality causes anxiety, and cost is also higher equal obvious insufficient.Urgently there is upgrading to produce
Product meet the rigid need in market of mainstream consumer group's rapid growth of new generation.
Summary of the invention
In order to overcome the drawbacks of the prior art, the object of the present invention is to provide one kind have it is clearing heat and detoxicating, it is anti-inflammatory antibacterial, dispel
Wet turbid, the anti-inflammatory antibacterial external application decontamination drug of the gynaecology for smelly itching-relieving efficacies of dispelling of dispelling because of the hyperemia caused by inflammation or glues vagina
Membrane damage plays the role of promoting to restore, and is used for women vaginitis, and leukorrhea amount is more, color Huang dirty smelly or pruritus vulvue or lochia
It is slowly not clean, and with hypogastric pain etc..It can be used as the skin externally used with safety cleaning decontamination medicine in women postpartum and special physiological period
Product.
Further, the present invention, which also resides in, provides a kind of preparation method of anti-inflammatory antibacterial external application decontamination drug of gynaecology, can be with
The extraction of raw material pharmaceutically active ingredient and the quality of application efficiency and product are improved, product meets higher sanitary standard, can reach
Organic food-grade quality, the women safely cleaning for being more in line with the special physiological phase just need.
In order to achieve the goal above, the technical scheme adopted by the invention is that:
A kind of anti-inflammatory antibacterial external application decontamination drug of gynaecology, effective component by following parts by weight raw material preparation and
At: 5~25 parts of tender folium artemisiae argyi, 5~25 parts of green tea, 5~30 parts of kuh-seng, 5~30 parts of Cortex Phellodendri, 5~30 parts of mulberry leaf, Blumea balsamifera 5~20
Part.
Preferably, the anti-inflammatory antibacterial external application decontamination drug of above-mentioned gynaecology, effective component by following parts by weight raw material
Be prepared: 10~25 parts of tender folium artemisiae argyi, 10~25 parts of green tea, 10~25 parts of kuh-seng, 10~25 parts of Cortex Phellodendri, 10~25 parts of mulberry leaf,
10~20 parts of Blumea balsamifera.
It is further preferred that the above-mentioned anti-inflammatory antibacterial external application decontamination drug of gynaecology, effective component is by following parts by weight
Raw material be prepared: 15 parts of tender folium artemisiae argyi, 15 parts of green tea, 20 parts of kuh-seng, 20 parts of Cortex Phellodendri, 20 parts of mulberry leaf, 10 parts of Blumea balsamifera.
The folium artemisiae argyi point bud that acquires before the Ching Ming Festival above-mentioned tender folium artemisiae argyi is current year, it is dry after 25~35 DEG C of low temperature spontaneous fermentation and
?；Blumea balsamifera is the Blumea balsamifera of current year fresh acquisition.
Following present invention, which provides, a kind of to be carried out processing for above-mentioned raw materials and obtains effective component therein and be processed into gynaecology
Anti-inflammatory antibacterial external application cleaning disappears the method for washing product, clearing heat and detoxicating to realize, anti-inflammatory antibacterial, and clearing damp is dispelled turbid, dispels smelly antipruritic
Effect.
A kind of anti-inflammatory antibacterial external application cleaning of gynaecology, which disappears, washes the preparation method of product, can carry out in accordance with the following steps:
S1. raw material crushes: weighing tender folium artemisiae argyi, green tea, kuh-seng, Cortex Phellodendri, mulberry leaf, Blumea balsamifera difference cleaning powder in parts by weight
It is spare that it is isolated and purified with moxa after broken, obtains comminuting matter；
S2. it impregnates: adding volumetric concentration to be that the ethanol water of 30-60% impregnates the comminuting matter in S1；
S3. wall-breaking abstraction: step S2 is impregnated into material by the continuous dynamic extraction of High Pressure Difference solvent fluid, obtains extract liquor；
S4. it is centrifugated: absolute extract liquid will be obtained after extract liquor centrifugation, filtering in S3；
S5. molecular sieve micro-filtration: the absolute extract liquid of step S4 is subjected to molecular sieve filtration, obtains target extract liquor；
S6. it is concentrated: after the target extract liquor of step S5 is recycled ethyl alcohol, successively carrying out reverse osmosis membrane concentration and vacuum decompression
Concentration, obtains thick medicinal extract, dry after thick medicinal extract is crystallized, and material is made and washes to get the anti-inflammatory antibacterial external application of gynaecology
Disappear drug.
Optionally, specially tender folium artemisiae argyi, green tea, kuh-seng, Cortex Phellodendri, mulberry leaf, Blumea balsamifera cleaning are crushed in step S1 to be crushed to
30~300 mesh.
Optionally, be specially in step S2 be added 15~30 times of volumetric concentration 30-60% ethanol water impregnate 10~
30min。
It optionally, is 3MPa~5MPa, high pressure by the low pressure of the continuous dynamic extraction of High Pressure Difference solvent fluid in step S3
For 18MPa~20MPa, Extracting temperature is 25~55 DEG C, and extraction time is 20~60min, and the solvent fluid is that volume is dense
Degree is the ethanol water of 30-60%.
Optionally, molecular sieve micro-filtration is successively to be sieved through filter by many-level molecule in step S5, wherein filtering molecular sieves for the first time
Filtration MW having a size of 10000nm~100000nm, the filtration MW of quadratic component sieve having a size of 50nm~800nm,
The filtration MW of last molecular sieve is having a size of 10~100nm.
Optionally, it after recycling ethyl alcohol first to target extract liquor in step S6, then carries out reverse osmosis membrane and is concentrated into Baume degrees
It is 2~15, then carries out being concentrated under reduced pressure into Baume degrees 20~35 under the conditions of vacuum degree -0.09MPa, 45~55 DEG C, obtain thick leaching
Cream.
The above-mentioned anti-inflammatory antibacterial external application decontamination drug of gynaecology is whole during the preparation process to use on-line near infrared spectroscopy analysis
Technology realizes the online timely, Visible human plan to product quality.
The above method can get the vegetable active crystallized stock of micro/nano level, belong to high loose crystalline solid, and when use can be straight
The warm water dissolution for connecing 50-100 times of addition, is subsequently used for the cleaning in women postpartum or special physiological period.It certainly can also be right
The further processing of above-mentioned material, such as be made nano liposomes, gel, emplastrum diversified forms gynecological external use decontamination makeups system
Product.
Gynecological external use decontamination drug of the present invention, using tender folium artemisiae argyi, green tea as monarch drug in a prescription, tender folium artemisiae argyi external application can temperature three-way meridian, clearing damp
Sterilization, antalgesic-antipruritic；Green tea is clearing heat and detoxicating, moisturizing deodorizing, dispel it is turbid；Green tea is cold.Document records its washout anti-inflammatory and releives,
Tea polyphenols possess natural convergence and antibacterial action, can not only clean skin, skin can also be protected from damage, it and tender Chinese mugwort
Folium artemisiae argyi can be reduced to mucocutaneous irritation with use, and can reinforce antibacterial and turbid smelly effect of dispelling of dispelling.Kuh-seng, Cortex Phellodendri are minister
Medicine, two medicines, which are shared, all has stronger lethality to bacterium, fungi.Kuh-seng decocting liquid to Escherichia coli, S. aureus L-forms, streptococcus,
Shigella dysenteriae etc. has inhibiting effect, and also there is kuh-seng preferable antipruritic and enhancing cellular immune function and antiallergy to make
With.Cortex Phellodendri is effective to S. aureus L-forms, pneumobacillus, streptococcus, shigella dysenteriae etc..Two medicines share washout bactericidal effect enhancing.Mulberry
Leaf, Blumea balsamifera are adjuvant.Mulberry leaf nature and flavor are sweet, bitter, tremble with fear.Washout also has certain antiinflammatory and bacteriostatic functions, but prior function
Can be to it is mucocutaneous play the role of nourishing repair, so all medicines in front are to the stimulation of skin and because of vagina caused by inflammation
Mucous hyperemia and damage have enriching yin and repair.Blumea balsamifera external application has certain inhibiting effect to fungi and bacterium, such as may be used
Inhibit S. aureus L-forms, Escherichia coli, Pseudomonas aeruginosa, Candida albicans, the volatile oil that secondly Blumea balsamifera is isolated can moisturize the skin, and promote
Into the growth and reparation of epidermis, there is synergistic effect with mulberry leaf in this respect.In short, all precise and appropriate compatibilities of medicine share, heat-clearing solution is played altogether
Poison, anti-inflammatory antibacterial, clearing damp is dispelled turbid, smelly antipruritic effect of dispelling, at the same to vagina because caused by inflammation hyperemia or mucosa injury have
Promote the effect restored.It can be used for women vaginitis, leukorrhea amount is more, and color Huang dirty smelly or pruritus vulvue or lochia are slowly not
Only, and with hypogastric pain etc..
Compared with prior art, the invention has the following advantages and beneficial effects:
1, the formula of innovative product of the present invention is made with tender folium artemisiae argyi, green tea, kuh-seng, Cortex Phellodendri, mulberry leaf, Blumea balsamifera Six-element medicine
The effective component of product, has clearing heat and detoxicating, and anti-inflammatory antibacterial, clearing damp is dispelled turbid, smelly antipruritic effect of dispelling, while to vagina because of inflammation
Caused hyperemia or mucosa injury plays the role of promoting to restore, and is used for women vaginitis, and leukorrhea amount is more, color Huang dirty smelly, or outer
Negative itch or lochia are slowly not clean, and with hypogastric pain etc., one kind can be provided for women special physiological phase whole body bathing more
The multifunctional cleaning articles of safety and fashion；
2, the present invention selects the continuous cleaning of dynamic to crush separation and Extraction moxa+High Pressure Difference solvent fluid broken wall+continuous repeatedly
Gradient molecule sieving+low temperature is concentrated and dried the combination of the molecules abstraction techniques such as crystallization+near infrared spectrum online process analysis procedure analysis, can be maximum
Limit goes the harmful components such as removing heavy metals, agriculture are residual, change is residual, bacterium, impurity, and efficiently, completely separates contained effective component
Extraction；And this extracting method is suitble to the manufacture of high-volume quantity-produced wisdom, and for overall process without heating, non-exhaust emission is raw
Fisheries water can be recycled and be recycled, and waste residue full price utilizes, and comply fully with green manufacturing standard, 4.0 intelligence with higher
The operability and ecological environment cost performance of intelligent manufacture；Product meets higher sanitary standard, can reach organic food-grade quality；
3, High Pressure Difference fluid extraction stage of the present invention, vacuum concentration stage and drying phase under vacuum, temperature control 35-55
Within DEG C, whole low temperature is more advantageous to compared with traditional water boiling and extraction technique and guarantees active principle activity；
4, present invention extraction material belongs to high loose crystalline solid, and molecular weight is small and uniformity is good, and dissolubility is good, it is cold and hot all
It is molten, and any excipients are not added, anticaking agent, the auxiliary materials such as flavoring agent, preservative are suitble to further manufacture the nanometer of Transdermal absorption
A variety of suitable formulations such as liposome, hydrogel, the scope of application is wider, safer；
5, product of the present invention effective component is small-molecule substance, is easily directly absorbed by local skin mucous membrane etc., raw
Object efficiency is significant, comparatively fast can play preferable nutrient energy to local skin and supplement and clean decontamination effect.
6, the Chinese medicine in inventive formulation, it is safe and non-toxic, it can be used for a long time, the safety suitable for the women special physiological phase is washed
Disappear cleaning and health care.
Specific embodiment
The technical scheme of the invention is described in detail through specific implementation examples.
The folium artemisiae argyi point bud acquired before the Ching Ming Festival tender folium artemisiae argyi is current year in following embodiments, and sent out naturally in 25~35 DEG C of low temperature
It is dry after ferment to obtain；Blumea balsamifera is the Blumea balsamifera of current year fresh acquisition.
Embodiment 1
A kind of anti-inflammatory antibacterial external application decontamination drug of gynaecology, effective component by following parts by weight raw material preparation and
At: tender folium artemisiae argyi 15g, green tea 15g, kuh-seng 20g, Cortex Phellodendri 20g, mulberry leaf 20g, Blumea balsamifera 10g.
Preparation method, including following operating procedure:
S1. raw material crushes: weighing tender folium artemisiae argyi, green tea, kuh-seng, Cortex Phellodendri, mulberry leaf, Blumea balsamifera in parts by weight and cleans and be crushed to
60~150 mesh, are then demultiplex out moxa, obtain comminuting matter；Collecting the moxa isolated can be used as other products materials；
S2. it impregnates: by the comminuting matter in S1, the volumetric concentration of 20 times of amounts is added as the immersion of 30% ethanol water
30min；
S3. wall-breaking abstraction: material is 4MPa in low pressure after step S2 is impregnated, high pressure 20MPa, Extracting temperature is 35~
The continuous Dynamic Extraction 45min of 30% ethanol water fluid of High Pressure Difference is utilized under the conditions of 50 DEG C, obtains extract liquor；
S4. it is centrifugated: absolute extract liquid will be obtained after extract liquor centrifugation, filtering in S3；
S5. molecular sieve micro-filtration: by the absolute extract liquid of step S4 for the first time filtering molecular sieve filtration MW having a size of
10000nm~100000nm, the filtration MW of quadratic component sieve is having a size of 50nm~800nm, the filtering point of last molecular sieve
Son is taken measurements as 10~100nm；
S6. be concentrated: after the target extract liquor of step S5 is recycled ethyl alcohol, successively carry out reverse osmosis membrane and be concentrated into Baume degrees be
2, obtain primary extract；Then it is -0.09MPa in vacuum degree by primary extract, carries out being concentrated under reduced pressure into Baume degrees under the conditions of 50 DEG C
25, obtain thick medicinal extract；It is dry after thick medicinal extract is crystallized, material is made to get the anti-inflammatory antibacterial external application decontamination of gynaecology
Drug.
Embodiment 2
A kind of anti-inflammatory antibacterial external application decontamination drug of gynaecology, effective component by following parts by weight raw material preparation and
At: 25 parts of tender folium artemisiae argyi, 25 parts of green tea, 10 parts of kuh-seng, 20 parts of Cortex Phellodendri, 5 parts of mulberry leaf, 15 parts of Blumea balsamifera.
The preparation method of the above-mentioned anti-inflammatory antibacterial external application decontamination drug of gynaecology, with embodiment 1.
Embodiment 3
A kind of anti-inflammatory antibacterial external application decontamination drug of gynaecology, effective component by following parts by weight raw material preparation and
At: 5 parts of tender folium artemisiae argyi, 25 parts of green tea, 30 parts of kuh-seng, 5 parts of Cortex Phellodendri, 15 parts of mulberry leaf, 20 parts of Blumea balsamifera.
The preparation method of the above-mentioned anti-inflammatory antibacterial external application decontamination drug of gynaecology, with embodiment 1.
Embodiment 4
A kind of anti-inflammatory antibacterial external application decontamination drug of gynaecology, effective component by following parts by weight raw material preparation and
At: 25 parts of tender folium artemisiae argyi, 5 parts of green tea, 5 parts of kuh-seng, 30 parts of Cortex Phellodendri, 30 parts of mulberry leaf, 5 parts of Blumea balsamifera.
The preparation method of the above-mentioned anti-inflammatory antibacterial external application decontamination drug of gynaecology, including following operating procedure:
S1. raw material crushes: weighing tender folium artemisiae argyi, green tea, kuh-seng, Cortex Phellodendri, mulberry leaf, Blumea balsamifera in parts by weight and cleans and be crushed to
30~150 mesh, are then demultiplex out moxa, obtain comminuting matter；The moxa isolated is collected as other products materials；
S2. it impregnates: by the comminuting matter in S1, the volumetric concentration of 30 times of amounts is added as the immersion of 40% ethanol water
10min；
S3. wall-breaking abstraction: material is 5MPa in low pressure after step S2 is impregnated, high pressure 19MPa, Extracting temperature is 25~
It is the continuous Dynamic Extraction 60min of 40% ethanol water fluid that High Pressure Difference volumetric concentration is utilized under the conditions of 40 DEG C, obtains extract liquor；
S4. it is centrifugated: absolute extract liquid will be obtained after extract liquor centrifugation, filtering in S3；
S5. molecular sieve micro-filtration: by the absolute extract liquid of step S4 for the first time filtering molecular sieve filtration MW having a size of
10000nm~100000nm, the filtration MW of quadratic component sieve is having a size of 50nm~800nm, the filtering point of last molecular sieve
Son is taken measurements as 10~100nm.
S6. be concentrated: after the target extract liquor of step S5 is recycled ethyl alcohol, successively carry out reverse osmosis membrane and be concentrated into Baume degrees be
15, obtain primary extract；Then it is -0.09MPa in vacuum degree by primary extract, carries out being concentrated under reduced pressure into Baume degrees under the conditions of 55 DEG C
35, obtain thick medicinal extract；It is dry after thick medicinal extract is crystallized, material is made to get the anti-inflammatory antibacterial external application decontamination medicine of gynaecology
Product.
Embodiment 5
A kind of anti-inflammatory antibacterial external application decontamination drug of gynaecology, effective component are prepared by following raw material in parts by weight:
10 parts of tender folium artemisiae argyi, 10 parts of green tea, 25 parts of kuh-seng, 25 parts of Cortex Phellodendri, 20 parts of mulberry leaf, 10 parts of Blumea balsamifera.
The preparation method of the above-mentioned anti-inflammatory antibacterial external application decontamination drug of gynaecology, including following operating procedure:
S1. raw material crushes: weighing tender folium artemisiae argyi, green tea, kuh-seng, Cortex Phellodendri, mulberry leaf, Blumea balsamifera in parts by weight and cleans and be crushed to
100~300 mesh, are then demultiplex out moxa, obtain comminuting matter；The moxa isolated is collected as other products materials；
S2. it impregnates: by the comminuting matter in S1, the volumetric concentration of 10 times of amounts is added as the immersion of 60% ethanol water
20min；
S3. wall-breaking abstraction: material is 3MPa in low pressure after step S2 is impregnated, high pressure 18MPa, Extracting temperature is 45~
It is the continuous Dynamic Extraction 20min of 60% ethanol water fluid that High Pressure Difference volumetric concentration is utilized under the conditions of 55 DEG C, obtains extract liquor；
S4. it is centrifugated: absolute extract liquid will be obtained after extract liquor centrifugation, filtering in S3；
S5. molecular sieve micro-filtration: by the absolute extract liquid of step S4, wherein the filtering molecular of filtering molecular sieve is taken measurements for the first time
For 10000nm~100000nm, the filtration MW of quadratic component sieve is having a size of 50nm~800nm, the filtering of last molecular sieve
Molecular weight sizes are 10~100nm.
S6. be concentrated: after the target extract liquor of step S5 is recycled ethyl alcohol, successively carry out reverse osmosis membrane and be concentrated into Baume degrees be
10, obtain primary extract；Then it is -0.09MPa in vacuum degree by primary extract, carries out being concentrated under reduced pressure into Baume degrees under the conditions of 45 DEG C
20, obtain thick medicinal extract；It is dry after thick medicinal extract is crystallized, material is made to get the gynecological external use decontamination drug.
Comparative example 1
This comparative example, effective component are prepared by following raw material in parts by weight: 50 parts of tender folium artemisiae argyi, 50 parts of green tea.
It is specific that the preparation method is the same as that of Example 1.
This comparative example difference from example 1 is that, keeping the total weight number of bulk pharmaceutical chemicals constant, and monarch drug in a prescription is tender
In the case that folium artemisiae argyi and green tea usage ratio are constant, ministerial drug and adjuvant are saved.Drug effect verification result shows compared to embodiment 1,
For the comparative example to postpartum women vaginitis, leukorrhea amount is more, and color Huang dirty smelly or pruritus vulvue or lochia are slowly not clean, and companion
Hypogastric pain and other effects reduces.
Comparative example 2
This comparative example, effective component are prepared by following raw material in parts by weight: 21 parts of tender folium artemisiae argyi, 21 parts of green tea,
29 parts of kuh-seng, 29 parts of Cortex Phellodendri.It is specific that the preparation method is the same as that of Example 1.
This comparative example difference from example 1 is that, keeping the total weight number of bulk pharmaceutical chemicals constant, and monarch drug in a prescription is tender
Folium artemisiae argyi and green tea, with the usage ratio of ministerial drug kuh-seng and Cortex Phellodendri it is constant in the case where, save adjuvant.Drug effect verification result shows
Compared to embodiment 1, for the comparative example to postpartum women vaginitis, leukorrhea amount is more, color Huang dirty smelly or pruritus vulvue or lochia
It is slowly not clean, and reduced with hypogastric pain and other effects.
Comparative example 3
This comparative example, effective component are prepared by following raw material in parts by weight:
15 parts of old folium artemisiae argyi, 15 parts of green tea, 20 parts of kuh-seng, 20 parts of Cortex Phellodendri, 20 parts of mulberry leaf, 10 parts of Blumea balsamifera；Wherein old folium artemisiae argyi
To acquire after Dragon Boat Festival current year, and the full folium artemisiae argyi at least expired 1 year or more is placed naturally.It is specific that the preparation method is the same as that of Example 1.
This comparative example difference from example 1 is that, tender folium artemisiae argyi, drug effect verification result table are replaced using old folium artemisiae argyi
It is bright, embodiment 1 is compared, for the comparative example to postpartum women vaginitis, leukorrhea amount is more, and color Huang dirty smelly or pruritus vulvue or postpartum are disliked
Dew is slowly not clean, and reduces with hypogastric pain and other effects.
Comparative example 4
This comparative example, effective component are prepared by following raw material in parts by weight:
15 parts of tender folium artemisiae argyi, 15 parts of green tea, 20 parts of radix scutellariae, 20 parts of Cortex Phellodendri, 20 parts of mulberry leaf, 10 parts of Blumea balsamifera, specific preparation side
Method is the same as embodiment 1.
This comparative example difference from example 1 is that, replaced using the radix scutellariae similar with the action and efficacy of kuh-seng bitter
Ginseng, drug effect verification result show that for the comparative example to postpartum women vaginitis, leukorrhea amount is more, color Huang dirty smelly compared to embodiment 1, or
Pruritus vulvue or lochia are slowly not clean, and reduce with hypogastric pain and other effects.
Comparative example 5
This comparative example, effective component are prepared by following raw material in parts by weight: 15 parts of tender folium artemisiae argyi, 15 parts of green tea,
20 parts of kuh-seng, 20 parts of dandelion, 20 parts of mulberry leaf, 10 parts of Blumea balsamifera；It is specific that the preparation method is the same as that of Example 1.
This comparative example difference from example 1 is that, using the same dandelion replacement with broad-spectrum antibacterial effect
Cortex Phellodendri, drug effect verification result show that for the comparative example to postpartum women vaginitis, leukorrhea amount is more, color Huang dirty smelly compared to embodiment 1,
Pruritus vulvue or lochia it is slowly not clean, and with hypogastric pain and other effects reduce.
Comparative example 6
This comparative example, effective component are prepared by following raw material in parts by weight: 15 parts of tender folium artemisiae argyi, 15 parts of peppermint,
20 parts of kuh-seng, 20 parts of Cortex Phellodendri, 20 parts of mulberry leaf, 10 parts of Blumea balsamifera；It is specific that the preparation method is the same as that of Example 1.
This comparative example difference from example 1 is that, green tea is replaced using peppermint, drug effect verification result shows phase
Than embodiment 1, for the comparative example to postpartum women vaginitis, leukorrhea amount is more, and color Huang dirty smelly or pruritus vulvue or lochia are slow
It is not clean late, and reduced with hypogastric pain and other effects.
Comparative example 7
This comparative example, effective component are prepared by following raw material in parts by weight: 4 parts of tender folium artemisiae argyi, 15 parts of green tea, hardship
Join 31 parts, 20 parts of Cortex Phellodendri, 20 parts of mulberry leaf, 10 parts of Blumea balsamifera.It is specific that the preparation method is the same as that of Example 1.
Compared with Example 1 compared with: the preparation method of comparative example does not change, but the proportion being formulated changes, the wherein tender Chinese mugwort of monarch drug in a prescription
The effect of leaf ratio reduces, temperature three-way meridian, dispelling cold, analgesic reduces, and ministerial drug kuh-seng ratio increases, and clearing heat and detoxicating, sterilization and anticorrosion is made
With enhancing, full side is clearing heat and detoxicating, anti-inflammatory antibacterial, and clearing damp is dispelled turbid, and smelly itching-relieving efficacies of dispelling just are not so good as former ratio comprehensively and work well,
The proportion of this formula is whole not in ratio range of the present invention, influences to be formulated effect, reduces therapeutic effect.
Comparative example 8
This comparative example, effective component are prepared by following raw material in parts by weight: 30 parts of tender folium artemisiae argyi, 4 parts of green tea, hardship
Join 20 parts, 21 parts of Cortex Phellodendri, 21 parts of mulberry leaf, 4 parts of Blumea balsamifera.It is specific that the preparation method is the same as that of Example 1.
Compared with Example 1 compared with: the preparation method of comparative example does not change, but the proportion being formulated changes, the wherein tender Chinese mugwort of monarch drug in a prescription
Leaf ratio increases, and green tea, Blumea balsamifera component ratio reduce, and moist skin, itching-relieving action reduce, the constant rate of other medicine,
Full side is clearing heat and detoxicating, anti-inflammatory antibacterial, and clearing damp is dispelled turbid, and smelly itching-relieving efficacies of dispelling just are not so good as former ratio comprehensively and work well, this formula
Proportion it is whole not in ratio range of the present invention, influence to be formulated effect, reduce therapeutic effect.
Comparative example 9
This comparative example, effective component are prepared by following raw material in parts by weight: 15 parts of tender folium artemisiae argyi, 15 parts of green tea,
35 parts of kuh-seng, 20 parts of Cortex Phellodendri, 10 parts of mulberry leaf, 5 parts of Blumea balsamifera.It is specific that the preparation method is the same as that of Example 1.
Compared with embodiment: the preparation method of comparative example does not change, but the proportion being formulated changes, wherein tender folium artemisiae argyi, green
Tea constant rate, kuh-seng ratio increase, kuh-seng bitter cold, cold increase, and mulberry leaf, Blumea balsamifera ratio reduce, and moisturizing effect reduces, entirely
Side it is clearing heat and detoxicating, it is anti-inflammatory antibacterial, clearing damp dispel it is turbid, smelly itching-relieving efficacies of dispelling just be not so good as former ratio comprehensively and work well, this formula
Proportion is whole not in ratio range of the present invention, influences to be formulated effect, reduces therapeutic effect.
By the drug effect verification result of above-mentioned comparative example and embodiment 1 it is found that ministerial drug or adjuvant when formula omit, formula
The type of middle replacement bulk pharmaceutical chemicals is the bulk pharmaceutical chemicals with same drug effect, changes the bulk pharmaceutical chemicals usage ratio of formula, can be made entire
The effect of formula, changes, so that effect declines, or cannot play more comprehensively comprehensive action and efficacy, or even will appear
Antibacterial action can only be played, apparent the effects of alleviating pruitus, alleviating postpartum extremities joint pain cannot be played, thus
It can be seen that the effective of decontamination drug is made in the tender folium artemisiae argyi of selection of the invention, green tea, kuh-seng, Cortex Phellodendri, mulberry leaf, Blumea balsamifera compounding
Ingredient makes to can be good at playing collaboration compatibility effect between each other, improve and rich using the particularity of each bulk pharmaceutical chemicals itself
Rich curative effect of medication.
Clinical effectiveness verification test:
Case is chosen: choosing the women vaginitis of the obvious bacterium of postpartum clinical diagnosis or fungal infection appearance, leukorrhea respectively
Amount is more, and color Huang dirty smelly or pruritus vulvue person's age at patient 120 of 25~40 years old, are randomly divided into 10 groups；It is clinical to choose postpartum
Obviously lochia occur does not move back person's age slowly at patient 120 of 25~40 years old for diagnosis, is randomly divided into 10 groups；
Every group of patient is corresponding respectively using the product of embodiment 1, comparative example 1~9；
Application method: washout is carried out after the warm water dissolution for taking product to be added 60 times or leaching is applied, twice daily；
Use the course for the treatment of: 14 days
Curative effect determinate standard:
It is effective: to wash symptom disappearance or integral after applying and reduce >=70%；
It is effective: to wash symptom after applying and improve, integral reduces >=30%, < 70%；
It is invalid: to wash and apply rear symptom without alleviation, or integral reduction < 30%.
Symptom integral quantitative criteria is as follows:
The effective percentage and inefficiency of every group of patient are counted, wherein efficient is (effective number+effective number)/total case
Number；Inefficiency is invalid number/total case number, as a result as shown in the table:
Embodiment 2, embodiment 3, clinical effectiveness and the embodiment 1 of 5 product of embodiment are basic is equal, embodiment 4 it is comprehensive
It closes effect and is not so good as embodiment 1, but comprehensive function effect is better than comparative example 1~9.
By the result of above-mentioned test example clinical effectiveness verification test it is found that 1 product of embodiment have it is significant clearing heat and detoxicating,
Anti-inflammatory antibacterial, clearing damp is dispelled turbid smelly antipruritic effect of dispelling, at the same to vagina because caused by inflammation hyperemia or mucosa injury have and promote
The effect of recovery is used for women vaginitis, and leukorrhea amount is more, and color Huang dirty smelly or pruritus vulvue or lochia are slowly not clean, and
The generations such as companion's hypogastric pain are significantly treated and relaxation effect.The usage ratio for changing inventive formulation bulk pharmaceutical chemicals, changes formula
Monarch compatibility, or even bulk pharmaceutical chemicals are being replaced with into other bulk pharmaceutical chemicals with same drug effect, it can all influence the entire of product
Effect.The present invention assists it between each other using the specific pharmacological property of bulk pharmaceutical chemicals by the suitable bulk pharmaceutical chemicals of selection of innovation
Same compatibility, while simplifying formula, so that the product of preparation has multi-efficiency, when can be used as women postpartum and special physiological
The skin externally used with safety of phase cleans decontamination product.
Finally, it should be noted that the above embodiments are merely illustrative of the technical solutions of the present invention, rather than its limitations；Although
Present invention has been described in detail with reference to the aforementioned embodiments, those skilled in the art should understand that: it still may be used
To modify the technical solutions described in the foregoing embodiments or equivalent replacement of some of the technical features；
And these are modified or replaceed, technical solution of various embodiments of the present invention that it does not separate the essence of the corresponding technical solution spirit and
Range.
Claims (10)
1. a kind of anti-inflammatory antibacterial external application decontamination drug of gynaecology, which is characterized in that its effective component by following parts by weight original
Material is prepared: 5 ~ 25 parts of tender folium artemisiae argyi, 5 ~ 25 parts of green tea, 5 ~ 30 parts of kuh-seng, 5 ~ 30 parts of Cortex Phellodendri, 5 ~ 30 parts of mulberry leaf, Blumea balsamifera 5 ~
20 parts.
2. the anti-inflammatory antibacterial external application decontamination drug of gynaecology as described in claim 1, which is characterized in that its effective component is by following
The raw material of parts by weight is prepared: 10 ~ 25 parts of tender folium artemisiae argyi, 10 ~ 25 parts of green tea, 10 ~ 25 parts of kuh-seng, 10 ~ 25 parts of Cortex Phellodendri, mulberry leaf
10 ~ 25 parts, 10 ~ 20 parts of Blumea balsamifera.
3. the anti-inflammatory antibacterial external application decontamination drug of gynaecology as described in claim 1, which is characterized in that its effective component is by following
The raw material of parts by weight is prepared: 15 parts of tender folium artemisiae argyi, 15 parts of green tea, 20 parts of kuh-seng, 20 parts of Cortex Phellodendri, 20 parts of mulberry leaf, Blumea balsamifera
10 parts.
4. a kind of preparation method of such as anti-inflammatory antibacterial external application decontamination drug of the described in any item gynaecology of claim 1 ~ 3, special
Sign is, including following operating procedure:
S1. raw material crushes: weighing after tender folium artemisiae argyi, green tea, kuh-seng, Cortex Phellodendri, mulberry leaf, Blumea balsamifera crush respectively and purifies in parts by weight
It is spare to isolate moxa, obtains comminuting matter；
S2. it impregnates: adding volumetric concentration to be that the ethanol water of 30-60% impregnates the comminuting matter in S1；
S3. wall-breaking abstraction: the material after step S2 is impregnated obtains extract liquor by the continuous dynamic extraction of High Pressure Difference solvent fluid；
S4. it is centrifugated: absolute extract liquid will be obtained after extract liquor centrifugation, filtering in S3；
S5. molecular sieve micro-filtration: the absolute extract liquid of step S4 is subjected to molecular sieve filtration, obtains target extract liquor；
S6. it is concentrated: after the target extract liquor of step S5 is recycled ethyl alcohol, successively carrying out reverse osmosis membrane concentration and vacuum decompression is dense
Contracting, obtains thick medicinal extract, dry after thick medicinal extract is crystallized, and material is made to get the anti-inflammatory antibacterial external application decontamination of gynaecology
Drug.
5. the preparation method of the anti-inflammatory antibacterial external application decontamination drug of gynaecology as claimed in claim 4, which is characterized in that step S3
In by the low pressure of the continuous dynamic extraction of High Pressure Difference solvent fluid be 3MPa ~ 5MPa, high pressure is 18MPa ~ 20MPa, Extracting temperature
It is 25 ~ 55 DEG C, extraction time is 20 ~ 60min, and the solvent fluid is the ethanol water that volumetric concentration is 30-60%.
6. the preparation method of the anti-inflammatory antibacterial external application decontamination drug of gynaecology as claimed in claim 4, which is characterized in that step S5
Middle molecular sieve micro-filtration be successively by many-level molecule be sieved through filter, wherein for the first time filtering molecular sieve filtration MW having a size of
10000nm ~ 100000nm, the filtration MW of quadratic component sieve is having a size of 50nm ~ 800nm, the filtering molecular of last molecular sieve
It takes measurements as 10~100nm.
7. the preparation method of the anti-inflammatory antibacterial external application decontamination drug of gynaecology as claimed in claim 4, which is characterized in that step S6
In ethyl alcohol recycling is carried out first to target extract liquor after, then carry out reverse osmosis membrane be concentrated into Baume degrees be 2 ~ 15, then in vacuum
Degree -0.09MPa carries out being concentrated under reduced pressure into Baume degrees 20 ~ 35 under the conditions of 45 ~ 55 DEG C, obtains thick medicinal extract.
8. the preparation method of the anti-inflammatory antibacterial external application decontamination drug of gynaecology as claimed in claim 4, which is characterized in that step S2
The ethanol water that 15 ~ 30 times of volumes of material are added impregnates 10 ~ 30min.
9. the preparation method of the anti-inflammatory antibacterial external application decontamination drug of gynaecology as claimed in claim 4, which is characterized in that step S1
It is middle to crush to be crushed to 30 ~ 300 mesh, purifies and separates Chinese mugwort after tender folium artemisiae argyi, green tea, kuh-seng, Cortex Phellodendri, mulberry leaf, Blumea balsamifera cleaning respectively
It is spare after suede.
10. the anti-inflammatory antibacterial external application decontamination drug of gynaecology that any preparation method of claim 4-9 obtains.
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