CN115671065B - Medicinal tablet for protecting liver and nourishing stomach and preparation method thereof - Google Patents
Medicinal tablet for protecting liver and nourishing stomach and preparation method thereof Download PDFInfo
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Classifications
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
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Abstract
The application discloses an edible tablet for protecting liver and nourishing stomach and a preparation method thereof, which belong to the technical field of medicines and comprise the following components in parts by weight: 6-10 parts of kudzuvine root, 4-8 parts of ginkgo, 10-15 parts of bighead atractylodes rhizome, 10-15 parts of medlar, 10-15 parts of semen cuscutae, 13-17 parts of liquorice, 10-15 parts of peppermint, 10-15 parts of honeysuckle and 10-15 parts of boat-fruited sterculia seed; the raw materials are mutually compatible, wherein the reasonable collocation of the kudzuvine root, the gingko, the medlar and the dodder can protect the liver; the bighead atractylodes rhizome, the medlar and the liquorice have the effects of strengthening spleen and nourishing stomach, the mint, the honeysuckle and the boat-fruited sterculia seed have the effects of clearing heat and detoxicating, the liquorice can alleviate the toxicity and the intensity of the medicines, and the medicines are synergistic together, so that the functions of strengthening middle-jiao and replenishing qi, strengthening spleen and nourishing stomach and nourishing liver and protecting the viscera can be achieved; the edible tablet is prepared by water preparation and fire preparation, so that the curative effect of the medicine is enhanced, the medicine performance is changed, and the prepared finished edible tablet has a refreshing taste.
Description
Technical Field
The application belongs to the technical field of medicines, and in particular relates to a medicinal tablet for protecting liver and nourishing stomach and a preparation method thereof.
Background
Liver is one of five viscera, is an organ mainly used for metabolism in vertebrate body, and has the functions of deoxidizing, storing glycation and secretion protein in the body; the stomach is also an important organ of vertebrates, mainly playing a digestive role. Excessive drinking can cause damage to liver and spleen, resulting in qi stagnation and blood stasis in the body and impairment of healthy qi, thereby causing a series of liver and spleen imbalance symptoms such as stomachache, dizziness, nausea, vomiting and the like
The existing products are separately carried out when the liver and stomach protection is realized, the functions of the products are single, and if the aim of liver and stomach protection is to be realized, the products need to be respectively supplemented; the liver-protecting and stomach-nourishing products are mostly in the form of tea or beverage, but the effects of liver protection and stomach nourishing cannot be achieved because the effects of the liver protection and stomach nourishing are affected if the soaking time of the beverage is too long and the taste is poor.
Disclosure of Invention
Therefore, the application aims to provide a medicinal tablet for protecting liver and nourishing stomach and a preparation method thereof, so as to solve the technical problems of single function and poor effect of the liver-protecting and stomach-nourishing products in the market at present.
In order to achieve the above purpose, the present application provides the following technical solutions:
the application provides a medicinal tablet for protecting liver and nourishing stomach, which comprises the following components in parts by weight: 6-10 parts of kudzuvine root, 4-8 parts of ginkgo, 10-15 parts of bighead atractylodes rhizome, 10-15 parts of medlar, 10-15 parts of semen cuscutae, 13-17 parts of liquorice, 10-15 parts of peppermint, 10-15 parts of honeysuckle and 10-15 parts of boat-fruited sterculia seed.
Further, the method comprises the following steps of: 8 parts of kudzuvine root, 6 parts of ginkgo, 13 parts of bighead atractylodes rhizome, 13 parts of medlar, 13 parts of semen cuscutae, 15 parts of liquorice, 13 parts of peppermint, 13 parts of honeysuckle and 13 parts of boat-fruited sterculia seed.
Further, the application also discloses a preparation method of the liver-protecting and stomach-nourishing medicinal tablet, which comprises the following steps:
s1: removing impurities on the surfaces of all the raw medicinal materials in the formula amount, adding water for soaking, and then airing;
s2: dividing all the raw materials into two equal parts according to the proportion of 3:7;
s3: grinding Glycyrrhrizae radix with the weight ratio of three, adding clear water to prepare Glycyrrhrizae radix solution, adding radix Puerariae, atractylodis rhizoma and semen Ginkgo with the weight ratio of three into Glycyrrhrizae radix solution, soaking, taking out radix Puerariae and Atractylodis rhizoma, air drying, and heating Glycyrrhrizae radix solution;
s4: decocting radix Puerariae, atractylodis rhizoma, semen Ginkgo and fructus Lycii, semen Cuscutae, herba Menthae, flos Lonicerae, and semen Scaphii Lychnophori in the step S3 to obtain decoction.
S5: soaking semen Ginkgo in the solution of step S3 for 75 min, air drying, parching with the rest radix Puerariae, atractylodis rhizoma, fructus Lycii, semen Cuscutae, glycyrrhrizae radix, herba Menthae, flos Lonicerae and semen Scaphii Lychnophori, and grinding into powder;
s6: adding water 7-8 times of the weight of the powder in the step S5, adjusting the pH value to weak acid environment, adding trace pectase, cellulase and protease for enzymolysis for 20-24 hours, controlling the temperature to be 45-50 ℃, and then carrying out reflux extraction, purification and concentration to obtain the ointment.
S7: slowly pouring the decoction obtained in the step S4 into the medicinal powder obtained in the step S6 to prepare the pharmaceutical tablet.
Further, in the step S6, pectase, cellulase and protease account for 0.15% of the total weight of the raw materials, wherein the weight ratio of pectase, cellulase and protease is 2:4:1.
Further, in the step S3, the soaking time of the kudzuvine root, the bighead atractylodes rhizome and the ginkgo is 60-90 minutes; heating semen Ginkgo at 35-40deg.C for 20-40 min.
Further, the decoction temperature in the step S4 is 85-95 ℃.
Further, the soaking temperature of the gingko in the step S5 is 60-90 minutes.
Further, the stir-frying temperature in the step S5 is 90-100 ℃.
The medicinal materials of the application are as follows:
radix Puerariae: has effects of dissolving ethanol, clearing heat, removing pathogenic fire, relieving hangover, and protecting liver. The kudzuvine root contains rich puerarin and flavonoid substances, and the substances can promote in vivo alcoholism, protect the liver, effectively improve the regeneration function of human liver cells and help the damaged liver cells to work normally.
Gingko seed: has effects of relieving hangover, regulating stomach function, astringing lung, relieving asthma, and stopping leukorrhagia, and can be used for treating discomfort of gastric cavity or injury caused by alcoholic heat due to excessive drinking.
White atractylodes rhizome: not only can tonify qi, invigorate spleen and strengthen transportation of spleen qi, but also can dry dampness and promote diuresis, and remove pathogenic factors of retained water dampness, so that the edema can be treated.
Medlar: has effects of nourishing kidney and liver, moistening lung, and relieving cough due to asthenia, dryness of lung, and diabetes.
Semen cuscutae: the liver-soothing tea is soft, moist and mild, warm and not dry, and is tonic but not greasy, and nourishing liver and kidney; the medlar is sweet and flat, soft and moist, and has the functions of nourishing sweat and kidney, improving eyesight and tonifying yang. Semen Cuscutae and fructus Lycii can be used for nourishing liver and kidney, and treating liver and kidney deficiency, soreness of waist and knees, sexual impotence, and dizziness.
Licorice root: is root and rhizome of Glycyrrhiza uralensis Fisch, glycyrrhiza glabra or Glycyrrhiza glabra of Leguminosae, has mild nature and sweet taste, has effects of invigorating spleen, replenishing qi, relieving spasm and pain, and can also relieve toxicity and intensity of the drug.
Peppermint: has effects of dispelling pathogenic wind and heat, removing toxic substances and promoting eruption, and clearing head and eyes, and herba Menthae can sooth liver and relieve depression, and regulate qi, and can relieve symptoms caused by liver qi discomfort such as hypochondriac pain, mood disorder, insomnia and dreaminess, and depression and oligopoliosis.
Honeysuckle flower: the product has sweet and cold nature, fragrant smell, gan Hanqing heat without hurting stomach, and good fragrance, and can be used for eliminating pathogenic factors, treating various febrile diseases, and improving fever, pharyngalgia, thirst, and toxic materials during early stage of exogenous wind-heat or warm disease.
Boat-fruited sterculia seed: has effects in relieving symptoms such as dry cough without phlegm, hoarseness, and laryngopharynx swelling and pain caused by wind-heat affecting lung, and can be used for relieving mucous membrane inflammation and spasmodic pain,
the application has the beneficial effects that:
1. the raw materials are mutually compatible, wherein the reasonable collocation of the kudzuvine root, the gingko, the medlar and the dodder can protect the liver; atractylodis rhizoma, fructus Lycii and Glycyrrhrizae radix have effects of invigorating spleen and nourishing stomach, herba Menthae, flos Lonicerae and semen Scaphii Lychnophori have effects of clearing heat and detoxicating, and Glycyrrhrizae radix can alleviate toxicity and intensity of the medicine. Several medicines are synergistic, and can play a role in well tonifying middle-jiao and Qi, strengthening spleen and stomach, nourishing liver and protecting viscera;
2. after the raw medicinal materials are crushed, the medicinal powder is subjected to enzymolysis, so that the production and preparation efficiency is improved, and macromolecules in the medicinal powder can be decomposed into small molecules through enzymolysis, so that effective components of the small molecules are separated out, and the small molecules are easy to be absorbed by a human body;
3. the medicinal tablet is prepared by water preparation and fire preparation respectively, so that the curative effect of the medicament is enhanced, the medicament performance is changed, and the preparation is conveniently adjusted; the medicinal tablet is prepared by adopting the principle of homology of medicine and food, and the prepared finished medicinal tablet has fresh and cool taste and is deeply favored by users.
Additional advantages, objects, and features of the application will be set forth in part in the description which follows and in part will become apparent to those having ordinary skill in the art upon examination of the following or may be learned from practice of the application. The objects and other advantages of the application may be realized and obtained by means of the instrumentalities and combinations particularly pointed out in the specification.
Detailed Description
The present application is further illustrated by the following examples, but the present application is not limited to these examples.
Example 1
The application provides a medicinal tablet for protecting liver and nourishing stomach, which comprises the following components in parts by weight: 8 parts of kudzuvine root, 6 parts of ginkgo, 13 parts of bighead atractylodes rhizome, 13 parts of medlar, 13 parts of semen cuscutae, 15 parts of liquorice, 13 parts of peppermint, 13 parts of honeysuckle and 13 parts of boat-fruited sterculia seed;
the application also provides a preparation method of the medicinal tablet for protecting liver and nourishing stomach, which comprises the following steps:
s1: removing impurities on the surfaces of all the raw medicinal materials in the formula amount, soaking in water for 75 minutes, and airing;
s2: dividing all the raw materials into two equal parts according to the proportion of 3:7;
s3: grinding Glycyrrhrizae radix with the weight ratio of three, adding 250ml of clear water to prepare Glycyrrhrizae radix solution, adding radix Puerariae, atractylodis rhizoma and semen Ginkgo with the weight ratio of three into Glycyrrhrizae radix solution, soaking for 75 min, taking out radix Puerariae and Atractylodis rhizoma, air drying, and heating Glycyrrhrizae radix solution at 38deg.C for 30 min;
s4: adding 500ml of clear water into the kudzuvine root, the bighead atractylodes rhizome, the gingko and the medlar, the semen cuscutae, the mint, the honeysuckle and the boat-fruited sterculia seed which are prepared in the step S3, and decocting to 90 ℃ until decoction is obtained.
S5: soaking semen Ginkgo in the solution of step S3 for 75 min, air drying, parching with the rest radix Puerariae, atractylodis rhizoma, fructus Lycii, semen Cuscutae, glycyrrhrizae radix, herba Menthae, flos Lonicerae and semen Scaphii Lychnophori at 100deg.C, and grinding into powder;
s6: adding 8 times of water by weight of the powder in the step S5, regulating the pH value to be weak acid environment, adding trace pectase, cellulase and protease accounting for 0.15% of the total weight of the raw materials, carrying out enzymolysis for 22 hours at the temperature of 47 ℃, and then carrying out reflux extraction, purification and concentration to obtain the ointment, wherein the ratio of pectase, cellulase and protease is 2:4:1.
S6: slowly pouring the decoction obtained in the step S4 into the ointment obtained in the step S6 to prepare the pharmaceutical tablet.
The principle and effect of the technical scheme are as follows:
the kudzuvine root can clear heat and reduce internal heat, improve the regeneration function of liver cells of a human body, help the damaged liver to work normally and has good curative effect on fatty liver; simultaneously, the kudzuvine root contains rich puerarin and brass substances, so that the in-vivo alcohol decomposition can be promoted, the alcohol can be dissolved, and the effects of dispelling the effects of alcohol and protecting the liver can be achieved; however, the kudzuvine root is cold and cool, and excessive kudzuvine root can cause the damage of spleen and stomach, so that liquorice is also needed to alleviate the drug property during pretreatment; semen Ginkgo has effects of moistening lung, astringing lung, relieving cough, clearing lung-heat, and relieving hangover and regulating stomach, and can be used for treating gastric cavity discomfort caused by drinking; however, gingko has slight toxicity, and the germs and the seed coats of gingko are removed, and then the gingko is soaked and heated by liquorice, so that the toxin is removed, and the bitter taste is removed; the bighead atractylodes rhizome has warm nature and has the effects of tonifying spleen and benefiting stomach, is used for tonifying stomach qi deficiency, tiredness and hypodynamia and abdominal distention, and can also remove the evil of water dampness in the retained body and treat edema after drinking; the medlar has the effects of nourishing kidney and liver and moistening lung, can also relieve consumptive cough, lung dryness and diabetes, and the semen cuscutae is soft and mild, not warm and not dry, and can nourish liver and kidney when being matched with the medlar, so that the aim of nourishing liver and kidney can be achieved; the liquorice is a leguminous plant, has flat nature and sweet taste, has the effects of tonifying spleen and replenishing qi, relieving spasm and pain and the like, and can relieve toxicity and intensity of the medicine, so the liquorice is used for soaking, heating and stir-frying the medicinal materials during preparation, and the medicine property can be relieved, and the original bitter taste in the medicinal materials can be removed; the mint has the effects of soothing liver and relieving depression and regulating qi, and can be used for relieving symptoms such as hypochondriac pain, poor mood, insomnia and dreaminess, depression and oligopoliosis caused by liver qi discomfort; simultaneously, the mint also has the functions of dispelling wind and heat, detoxifying and penetrating the symptoms and clearing the head and eyes; honeysuckle flower, sweet and cold nature, fragrant smell without hurting stomach, fragrant smell reaching, can eliminate pathogenic factor, can be used for treating various febrile diseases, can be used for improving fever, sore throat, thirst and detoxication and dysentery at the early stage of exogenous wind-heat or warm disease, and can also relieve thirst after drinking, sore throat and other effects; the scaphium scaphigerum can clear lung qi, detoxify and reduce internal heat, wherein the scaphium scaphigerum has the function of contracting vascular smooth muscle and relieving symptoms such as hoarseness, sore throat and the like after drinking.
The medicinal tablet raw materials disclosed by the application have the advantages that the kudzuvine root, the gingko and the largehead atractylodes rhizome can be matched to protect the liver, the liver discomfort can be alleviated, meanwhile, the largehead atractylodes rhizome, the medlar, the dodder seed and the mint can be matched to protect the stomach, nourish the stomach, sooth liver and relieve depression, the mint, the honeysuckle and the boat-fruited sterculia seed can be matched to clear away heat and toxic materials and relieve sore throat, and the medicinal tablet prepared by the formula can be used for normal medicine, protecting the liver and nourishing the stomach, and can also be taken after or before drinking, relieve the liver and stomach discomfort caused by drinking while alleviating the effect of alleviating the thirst after drinking and the injury of sore throat.
Example 2
The application provides a medicinal tablet for protecting liver and nourishing stomach, which comprises the following components in parts by weight: 10 parts of kudzuvine root, 7 parts of ginkgo, 12 parts of bighead atractylodes rhizome, 11 parts of medlar, 14 parts of semen cuscutae, 15 parts of liquorice, 10 parts of peppermint, 14 parts of honeysuckle and 11 parts of boat-fruited sterculia seed; the preparation method of the pharmaceutical tablet of example 2 is the same as that of example 1, and will not be described here again.
Example 3
The application provides a medicinal tablet for protecting liver and nourishing stomach, which comprises the following components in parts by weight: 6 parts of kudzuvine root, 7 parts of ginkgo, 14 parts of bighead atractylodes rhizome, 15 parts of medlar, 14 parts of semen cuscutae, 16 parts of liquorice, 14 parts of peppermint, 10 parts of honeysuckle and 14 parts of boat-fruited sterculia seed; the preparation method of the pharmaceutical tablet of example 3 is the same as that of example 1, and will not be described here again.
9 adult males with liver and stomach discomfort were selected and evenly divided into three groups, and the finished medicinal tablets of example 1-example 3 were taken once daily for 15 consecutive days, and the change results are shown in table 1:
TABLE 1
As can be seen from table 1: in combination with the comparison, the pharmaceutical tablet prepared from the raw material formulation of example 1 achieves the best effect, and has remarkable effect of improving liver-stomach disorder and mental fatigue, whereas the pharmaceutical tablet prepared from the raw material formulation of example 1 achieves the best effect, although the effect of example 2 and example 3 is not as remarkable as that of the raw material formulation of example 1, but also has a certain degree of improvement on the liver and stomach of the subject. After 9 subjects take the medicinal tablets prepared from the raw medicinal materials in the formula, the discomfort of the medicinal tablets is improved, the effects of soothing liver and relieving depression, harmonizing qi and nourishing stomach are achieved, the effects of relieving burning after drinking, dizziness and the like are achieved, the effects of reducing blood pressure, reducing blood sugar and clearing heat are achieved, and the medicinal tablets are convenient for the users to carry about, are not required to be soaked in water, and are convenient and quick to take directly.
In order to demonstrate the superiority of the pharmaceutical tablet stock formulation of the present application, comparative examples 1-4 were designed herein:
comparative example 1
The weight portion of the composition comprises: 5 parts of kudzuvine root, 9 parts of ginkgo, 8 parts of bighead atractylodes rhizome, 10 parts of medlar, 9 parts of semen cuscutae, 12 parts of liquorice, 9 parts of peppermint, 9 parts of honeysuckle and 9 parts of boat-fruited sterculia seed;
a method for preparing a pharmaceutical tablet according to a formulation:
s1: removing impurities on the surfaces of all the raw medicinal materials in the formula amount, soaking in water for 75 minutes, and airing;
s2: dividing all the raw materials into two equal parts according to the proportion of 3:7;
s3: grinding Glycyrrhrizae radix with the ratio of three, adding 150ml clear water to prepare Glycyrrhrizae radix solution, adding radix Puerariae, atractylodis rhizoma and semen Ginkgo with the ratio of three into Glycyrrhrizae radix solution, soaking for 75 min, taking out radix Puerariae and Atractylodis rhizoma, air drying, heating Glycyrrhrizae radix solution to 38deg.C and heating for 30 min;
s4: adding 150ml of clear water into the kudzuvine root, the bighead atractylodes rhizome, the gingko and the medlar, the semen cuscutae, the mint, the honeysuckle and the boat-fruited sterculia seed which are prepared in the step S3, decocting to 90 ℃, and decocting to obtain decoction.
S5, soaking and heating the gingko with the proportion of seven in the liquorice liquid in the step S3 for 30 minutes, taking out and airing, stir-frying the gingko, the rest of kudzuvine root, largehead atractylodes rhizome, medlar, semen cuscutae, liquorice, mint, honeysuckle and boat-fruited sterculia seed, and grinding the mixture into powder after stir-frying;
s6: adding 8 times of water by weight of the powder in the step S5, regulating the pH value to be weak acid environment, adding trace pectase, cellulase and protease accounting for 0.15% of the total weight of the raw materials, carrying out enzymolysis for 22 hours at the temperature of 47 ℃, and then carrying out reflux extraction, purification and concentration to obtain the ointment, wherein the ratio of pectase, cellulase and protease is 2:4:1.
S7, slowly pouring the decoction obtained in the step S4 into the ointment obtained in the step S6 to prepare the pharmaceutical tablet.
Comparative example 2
The weight portion of the composition comprises: 11 parts of kudzuvine root, 9 parts of ginkgo, 9 parts of bighead atractylodes rhizome, 16 parts of medlar, 16 parts of semen cuscutae, 12 parts of liquorice, 9 parts of peppermint, 9 parts of honeysuckle and 9 parts of boat-fruited sterculia seed;
comparative example 2 the process for preparing a pharmaceutical tablet is the same as that of comparative example 1 and will not be described in detail here.
In order to demonstrate the superiority of the method for producing pharmaceutical tablets of the present application, comparative examples 3 to 4 were designed herein, and pharmaceutical tablets of comparative examples 3 to 4 were produced using the raw material formulation of example 1 because the raw material formulation of example 1 had the optimal medicinal material content range.
Comparative example 3
The weight portion of the composition comprises: 8 parts of kudzuvine root, 6 parts of ginkgo, 13 parts of bighead atractylodes rhizome, 13 parts of medlar, 13 parts of semen cuscutae, 15 parts of liquorice, 13 parts of peppermint, 13 parts of honeysuckle and 13 parts of boat-fruited sterculia seed;
a pharmaceutical tablet is prepared as follows:
s1: removing impurities from all the medicinal materials, soaking and airing;
s2: grinding the dried medicinal materials into medicinal powder;
s3: the medicinal tablet is prepared by flooding the water into the tablet.
Comparative example 4
The weight portion of the composition comprises: 8 parts of kudzuvine root, 6 parts of ginkgo, 13 parts of bighead atractylodes rhizome, 13 parts of medlar, 13 parts of semen cuscutae, 15 parts of liquorice, 13 parts of peppermint, 13 parts of honeysuckle and 13 parts of boat-fruited sterculia seed;
a pharmaceutical tablet is prepared as follows:
s1: removing impurities on the surfaces of all the raw medicinal materials in the formula amount, soaking in water for 50 minutes, and airing;
s2: dividing all the raw materials into two equal parts according to the proportion of 5:5;
s3: grinding Glycyrrhrizae radix with the weight ratio of five, adding 250ml clear water to prepare Glycyrrhrizae radix solution, adding radix Puerariae, atractylodis rhizoma and semen Ginkgo with the weight ratio of three into Glycyrrhrizae radix solution, soaking for 15 min, taking out radix Puerariae and Atractylodis rhizoma, air drying, and heating Glycyrrhrizae radix solution at 50deg.C for 60 min;
s4: adding 500ml of clear water into the kudzuvine root, the bighead atractylodes rhizome, the gingko and the medlar, the semen cuscutae, the mint, the honeysuckle and the boat-fruited sterculia seed which are prepared in the step S3, and decocting to 80 ℃ until decoction is obtained.
S5, soaking and heating the gingko with the proportion of five in the liquorice liquid in the step S3 for 30 minutes, taking out and airing, stir-frying the gingko, the rest of kudzuvine root, largehead atractylodes rhizome, medlar, semen cuscutae, liquorice, mint, honeysuckle and boat-fruited sterculia seed, and grinding the mixture into powder after stir-frying;
s6, slowly pouring the decoction obtained in the step S4 into the medicinal powder obtained in the step S5 to prepare the pharmaceutical tablet.
12 adult males with liver and stomach discomfort were selected and evenly divided into four groups, and the finished pharmaceutical tablets of comparative examples 1 to 4 were taken once daily for 15 days, and the results are shown in table 2:
TABLE 2
As can be seen from table 2: wherein 6 subjects take the medicinal tablets prepared by the raw material formulas of the comparative example 1 and the comparative example 2, and the effects of soothing liver-qi stagnation and nourishing qi and stomach are general; the anti-alcohol effect is general, and the conditions such as stomach burning, dizziness and the like still exist; in addition, 6 subjects took the pharmaceutical tablets prepared by the raw material formulation of example 2 and the methods of comparative example 3 and comparative example 4, and the effects of soothing liver-qi stagnation and nourishing stomach were not achieved, and the pharmaceutical tablets had bitter taste and were difficult to swallow.
In conclusion, as can be seen from examples 1-3 and comparative examples 1-4, the raw materials adopting the formula of the application are matched with the preparation method of the application, and the medicinal tablet has obvious effects of soothing liver and relieving depression, harmonizing qi and nourishing stomach, and treating deficiency-cold of spleen and stomach and mental fatigue after being taken; the active ingredients of the raw material medicine powder which is not subjected to enzymolysis are not as high as the purity of the raw material ointment subjected to enzymolysis; and the raw material formula is not in the range of the application, and the improvement degree of the formula can not reach the treatment effect after the administration of the subject.
Finally, it is noted that the above-mentioned preferred embodiments are only intended to illustrate rather than limit the application, and that, although the application has been described in detail by means of the above-mentioned preferred embodiments, it will be understood by those skilled in the art that various changes in form and details may be made therein without departing from the scope of the application as defined by the appended claims.
Claims (6)
1. A medicinal tablet for protecting liver and nourishing stomach, which is characterized in that: the coating comprises the following components in parts by weight: 6-10 parts of kudzuvine root, 4-8 parts of ginkgo, 10-15 parts of bighead atractylodes rhizome, 10-15 parts of medlar, 10-15 parts of semen cuscutae, 13-17 parts of liquorice, 10-15 parts of peppermint, 10-15 parts of honeysuckle and 10-15 parts of boat-fruited sterculia seed;
the preparation method of the medicinal tablet comprises the following steps:
s1: removing impurities on the surfaces of all the raw medicinal materials in the formula amount, adding water for soaking, and then airing;
s2: dividing all the raw materials into two equal parts according to the proportion of 3:7;
s3: grinding Glycyrrhrizae radix with weight ratio of 3, adding clear water to prepare Glycyrrhrizae radix solution, adding radix Puerariae, atractylodis rhizoma and semen Ginkgo with weight ratio of 3 into Glycyrrhrizae radix solution, soaking, taking out radix Puerariae and Atractylodis rhizoma, air drying, and heating Glycyrrhrizae radix solution;
s4: decocting radix Puerariae, atractylodis rhizoma, semen Ginkgo in step S3 with fructus Lycii, semen Cuscutae, herba Menthae, flos Lonicerae, and semen Scaphii Lychnophori in proportion of 3 to obtain decoction.
S5: soaking semen Ginkgo in proportion of 7 in the Glycyrrhrizae radix solution of step S3, heating for 75 min, taking out, air drying, parching with the rest radix Puerariae, atractylodis rhizoma, fructus Lycii, semen Cuscutae, glycyrrhrizae radix, herba Menthae, flos Lonicerae and semen Scaphii Lychnophori, and grinding into powder;
s6: adding water 7-8 times of the weight of the powder in the step S5, adjusting the pH value to weak acid environment, adding trace pectase, cellulase and protease for enzymolysis for 20-24 hours, controlling the temperature to be 45-50 ℃, and then carrying out reflux extraction, purification and concentration to obtain ointment;
s7: slowly pouring the decoction obtained in the step S4 into the ointment obtained in the step S6 to prepare the pharmaceutical tablet.
2. A pharmaceutical tablet for protecting liver and nourishing stomach according to claim 1, wherein: the coating comprises the following components in parts by weight: 8 parts of kudzuvine root, 6 parts of ginkgo, 13 parts of bighead atractylodes rhizome, 13 parts of medlar, 13 parts of semen cuscutae, 15 parts of liquorice, 13 parts of peppermint, 13 parts of honeysuckle and 13 parts of boat-fruited sterculia seed.
3. A pharmaceutical tablet for protecting liver and nourishing stomach according to claim 1, wherein: in the step S6, pectase, cellulase and protease are 0.15% of the total weight of the raw materials, wherein the weight ratio of pectase, cellulase and protease is 2:4:1.
4. A pharmaceutical tablet for protecting liver and nourishing stomach according to claim 1, wherein: in the step S3, the soaking time of the kudzuvine root, the bighead atractylodes rhizome and the ginkgo is 60-90 minutes.
5. A pharmaceutical tablet for protecting liver and nourishing stomach according to claim 1, wherein: the decoction temperature in the step S4 is 85-95 ℃.
6. A pharmaceutical tablet for protecting liver and nourishing stomach according to claim 1, wherein: the stir-frying temperature in the step S5 is 90-100 ℃.
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| CN103392866A (en) * | 2013-07-12 | 2013-11-20 | 苏州市天灵中药饮片有限公司 | Stomach nourishing tea |
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| CN102846963A (en) * | 2012-08-31 | 2013-01-02 | 安徽大学 | Compound traditional Chinese medicine extract preparation capable of promoting sobering and preventing inebriation, and preparation method and application thereof |
| CN103392866A (en) * | 2013-07-12 | 2013-11-20 | 苏州市天灵中药饮片有限公司 | Stomach nourishing tea |
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| 三清方饮料清热作用观察;张平等;《医学动物防制》;第第33卷卷(第第04期期);410-414 * |
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