CN115667538A - 用于制备龙涎缩醛或龙涎缩醛同系物的酶介导的方法 - Google Patents

用于制备龙涎缩醛或龙涎缩醛同系物的酶介导的方法 Download PDF

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CN115667538A
CN115667538A CN202180038965.8A CN202180038965A CN115667538A CN 115667538 A CN115667538 A CN 115667538A CN 202180038965 A CN202180038965 A CN 202180038965A CN 115667538 A CN115667538 A CN 115667538A
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Chinese (zh)
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E·艾克霍恩
F·弗拉克斯曼
A·格克
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Givaudan SA
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/18—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
    • C12P17/181—Heterocyclic compounds containing oxygen atoms as the only ring heteroatoms in the condensed system, e.g. Salinomycin, Septamycin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D313/00—Heterocyclic compounds containing rings of more than six members having one oxygen atom as the only ring hetero atom
    • C07D313/02—Seven-membered rings
    • C07D313/06—Seven-membered rings condensed with carbocyclic rings or ring systems
    • C07D313/08—Seven-membered rings condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/08—Bridged systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/10—Spiro-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11B—PRODUCING, e.g. BY PRESSING RAW MATERIALS OR BY EXTRACTION FROM WASTE MATERIALS, REFINING OR PRESERVING FATS, FATTY SUBSTANCES, e.g. LANOLIN, FATTY OILS OR WAXES; ESSENTIAL OILS; PERFUMES
    • C11B9/00—Essential oils; Perfumes
    • C11B9/0069—Heterocyclic compounds
    • C11B9/0073—Heterocyclic compounds containing only O or S as heteroatoms
    • C11B9/008—Heterocyclic compounds containing only O or S as heteroatoms the hetero rings containing six atoms
    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11B—PRODUCING, e.g. BY PRESSING RAW MATERIALS OR BY EXTRACTION FROM WASTE MATERIALS, REFINING OR PRESERVING FATS, FATTY SUBSTANCES, e.g. LANOLIN, FATTY OILS OR WAXES; ESSENTIAL OILS; PERFUMES
    • C11B9/00—Essential oils; Perfumes
    • C11B9/0069—Heterocyclic compounds
    • C11B9/0073—Heterocyclic compounds containing only O or S as heteroatoms
    • C11B9/0084—Heterocyclic compounds containing only O or S as heteroatoms the hetero rings containing more than six atoms
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/90—Isomerases (5.)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/02—Oxygen as only ring hetero atoms
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y504/00—Intramolecular transferases (5.4)
    • C12Y504/99—Intramolecular transferases (5.4) transferring other groups (5.4.99)
    • C12Y504/99017—Squalene--hopene cyclase (5.4.99.17)

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Fats And Perfumes (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Cosmetics (AREA)
CN202180038965.8A 2020-04-15 2021-04-14 用于制备龙涎缩醛或龙涎缩醛同系物的酶介导的方法 Pending CN115667538A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB2005468.0 2020-04-15
GBGB2005468.0A GB202005468D0 (en) 2020-04-15 2020-04-15 Enzyme-media process
PCT/EP2021/059618 WO2021209482A1 (en) 2020-04-15 2021-04-14 Enzyme-mediated process for making amberketal and amberketal homologues

Publications (1)

Publication Number Publication Date
CN115667538A true CN115667538A (zh) 2023-01-31

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CN202180038965.8A Pending CN115667538A (zh) 2020-04-15 2021-04-14 用于制备龙涎缩醛或龙涎缩醛同系物的酶介导的方法

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Country Link
US (1) US12584153B2 (enExample)
EP (1) EP4136246A1 (enExample)
JP (1) JP2023522021A (enExample)
CN (1) CN115667538A (enExample)
BR (1) BR112022020144A2 (enExample)
GB (1) GB202005468D0 (enExample)
IL (1) IL297267A (enExample)
MX (1) MX2022012296A (enExample)
WO (1) WO2021209482A1 (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN117597334A (zh) * 2021-06-23 2024-02-23 奇华顿股份有限公司 制备金合欢烯的环氧化物衍生物的方法及其在进一步合成中的用途

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB202010072D0 (en) * 2020-07-01 2020-08-12 Givaudan Sa Enzyme-mediated process
IL312203A (en) 2021-10-21 2024-06-01 Givaudan Sa Improved methods and enzymes
GB202115120D0 (en) 2021-10-21 2021-12-08 Givaudan Sa Organic compounds
CN119137269A (zh) 2022-03-17 2024-12-13 奇华顿股份有限公司 Shc酶和酶变体
GB202210937D0 (en) 2022-07-27 2022-09-07 Givaudan Sa Process
GB202219135D0 (en) 2022-12-19 2023-02-01 Givaudan Sa Process
GB202313239D0 (en) 2023-08-31 2023-10-18 Givaudan Sa Organic compounds
GB202409304D0 (en) 2024-06-27 2024-08-14 Givauden Sa Process

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3144465A (en) * 1961-01-12 1964-08-11 Firmenich & Cie Internal ketals from dihydro-gammaionone, dihydro-gamma-irone and 5, 5, 9-trimethyl-2-methylene-1-(3'-oxobutyl-1')-decahydronaphthalene
CN102449158A (zh) * 2009-06-05 2012-05-09 巴斯夫欧洲公司 龙涎呋喃的生物催化产生
CN107002105A (zh) * 2014-09-29 2017-08-01 巴斯夫欧洲公司 生物催化环化香叶基芳樟醇的方法和由此获得的环化产物
CN109072265A (zh) * 2016-02-19 2018-12-21 巴斯夫欧洲公司 高法呢酸的酶促环化

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DE19649655A1 (de) 1996-11-29 1998-06-04 Haarmann & Reimer Gmbh Syntheseenzyme für die Herstellung von Coniferylalkohol, Coniferylaldehyd, Ferulasäure, Vanillin und Vanillinsäure und deren Verwendung
DE19960106A1 (de) 1999-12-14 2001-06-21 Haarmann & Reimer Gmbh Enzyme und Gene für die Herstellung von Vanillin
JP5236233B2 (ja) 2007-09-04 2013-07-17 花王株式会社 （−）−アンブロキサンの製造方法
EP4112727A3 (de) 2010-11-17 2023-03-15 Basf Se Verfahren zur biokatalytischen cyclisierung von terpenen und darin einsetzbare cyclase-mutanten
KR101251793B1 (ko) 2010-11-26 2013-04-08 현대자동차주식회사 차량내 운전자 실제 얼굴 인증 방법
GB201507207D0 (en) 2015-04-24 2015-06-10 Givaudan Sa Enzymes and applications thereof
GB201601249D0 (en) 2016-01-22 2016-03-09 Firmenich & Cie Production of manool
MX386546B (es) 2016-12-22 2025-03-19 Firmenich & Cie Producción de manool.
JP2020508651A (ja) 2017-02-24 2020-03-26 インターナショナル フレーバーズ アンド フラグランシズ インコーポレイテッド スクアレンホペンシクラーゼ、およびアンブロキサンを生成するためのその使用

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3144465A (en) * 1961-01-12 1964-08-11 Firmenich & Cie Internal ketals from dihydro-gammaionone, dihydro-gamma-irone and 5, 5, 9-trimethyl-2-methylene-1-(3'-oxobutyl-1')-decahydronaphthalene
CN102449158A (zh) * 2009-06-05 2012-05-09 巴斯夫欧洲公司 龙涎呋喃的生物催化产生
CN107002105A (zh) * 2014-09-29 2017-08-01 巴斯夫欧洲公司 生物催化环化香叶基芳樟醇的方法和由此获得的环化产物
CN109072265A (zh) * 2016-02-19 2018-12-21 巴斯夫欧洲公司 高法呢酸的酶促环化

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
J.S. YADAV等: "Synthesis of (+)-amberketal and its analog from l-abietic acid", 《TETRAHEDRON》, vol. 63, no. 39, 27 June 2007 (2007-06-27), pages 3 - 4 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN117597334A (zh) * 2021-06-23 2024-02-23 奇华顿股份有限公司 制备金合欢烯的环氧化物衍生物的方法及其在进一步合成中的用途

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JP2023522021A (ja) 2023-05-26
US20230175027A1 (en) 2023-06-08
US12584153B2 (en) 2026-03-24
MX2022012296A (es) 2022-10-27
GB202005468D0 (en) 2020-05-27
EP4136246A1 (en) 2023-02-22
BR112022020144A2 (pt) 2023-02-28
IL297267A (en) 2022-12-01
WO2021209482A1 (en) 2021-10-21

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