CN115667247A - 吡啶类衍生物及其应用 - Google Patents

吡啶类衍生物及其应用 Download PDF

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Publication number
CN115667247A
CN115667247A CN202180036433.0A CN202180036433A CN115667247A CN 115667247 A CN115667247 A CN 115667247A CN 202180036433 A CN202180036433 A CN 202180036433A CN 115667247 A CN115667247 A CN 115667247A
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compound
added
synthesis
solution
esi
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CN202180036433.0A
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CN115667247B (zh
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罗云富
巴庾勇
陈曙辉
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Medshine Discovery Inc
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Medshine Discovery Inc
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4433—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with oxygen as a ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/54—Improvements relating to the production of bulk chemicals using solvents, e.g. supercritical solvents or ionic liquids

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicinal Preparation (AREA)

Abstract

本发明公开了一系列带有吡啶结构的化合物或其药学上可接受的盐，及其在制备治疗相关疾病的药物中的应用，具体公开了式(Ι)所示化合物或其药学上可接受的盐。

Description

PCT国内申请，说明书已公开。

Claims (8)

  1. PCT国内申请，权利要求书已公开。
CN202180036433.0A 2020-05-22 2021-05-19 吡啶类衍生物及其应用 Active CN115667247B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CN202010444113 2020-05-22
CN2020104441136 2020-05-22
PCT/CN2021/094677 WO2021233349A1 (zh) 2020-05-22 2021-05-19 吡啶类衍生物及其应用

Publications (2)

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CN115667247A true CN115667247A (zh) 2023-01-31
CN115667247B CN115667247B (zh) 2024-04-12

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CN202180036433.0A Active CN115667247B (zh) 2020-05-22 2021-05-19 吡啶类衍生物及其应用

Country Status (10)

Country Link
US (1) US20230183221A1 (zh)
EP (1) EP4159730A4 (zh)
JP (1) JP7502467B2 (zh)
KR (1) KR20230013101A (zh)
CN (1) CN115667247B (zh)
AU (1) AU2021276287A1 (zh)
BR (1) BR112022023732A2 (zh)
CA (1) CA3179593A1 (zh)
MX (1) MX2022014523A (zh)
WO (1) WO2021233349A1 (zh)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN113412261A (zh) * 2019-04-08 2021-09-17 四川科伦博泰生物医药股份有限公司 苯并咪唑化合物、其制备方法及其用途

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003014105A1 (en) * 2001-08-08 2003-02-20 Takeda Chemical Industries, Ltd. Bicyclic compound, production and use as hiv inhibitors
CN108289881A (zh) * 2015-09-16 2018-07-17 妥必徕疗治公司 用于治疗纤维化的赛尼克韦罗联合疗法
CN110023286A (zh) * 2016-12-09 2019-07-16 南京明德新药研发股份有限公司 作为ccr2/ccr5受体拮抗剂的联苯化合物
WO2019149089A1 (zh) * 2018-02-02 2019-08-08 四川科伦博泰生物医药股份有限公司 含有羧酸基团的苯并氮杂环类化合物及其制备方法和用途

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2001058992A (ja) 1999-06-16 2001-03-06 Takeda Chem Ind Ltd ベンゾアゼピン誘導体、その製造法および用途
JP2003119191A (ja) 2001-08-08 2003-04-23 Takeda Chem Ind Ltd ベンゾアゼピン誘導体、その製造法および用途

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003014105A1 (en) * 2001-08-08 2003-02-20 Takeda Chemical Industries, Ltd. Bicyclic compound, production and use as hiv inhibitors
CN108289881A (zh) * 2015-09-16 2018-07-17 妥必徕疗治公司 用于治疗纤维化的赛尼克韦罗联合疗法
CN110023286A (zh) * 2016-12-09 2019-07-16 南京明德新药研发股份有限公司 作为ccr2/ccr5受体拮抗剂的联苯化合物
WO2019149089A1 (zh) * 2018-02-02 2019-08-08 四川科伦博泰生物医药股份有限公司 含有羧酸基团的苯并氮杂环类化合物及其制备方法和用途

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN113412261A (zh) * 2019-04-08 2021-09-17 四川科伦博泰生物医药股份有限公司 苯并咪唑化合物、其制备方法及其用途

Also Published As

Publication number Publication date
EP4159730A4 (en) 2024-05-01
CA3179593A1 (en) 2021-11-25
MX2022014523A (es) 2022-12-13
EP4159730A1 (en) 2023-04-05
WO2021233349A1 (zh) 2021-11-25
AU2021276287A1 (en) 2023-01-19
JP7502467B2 (ja) 2024-06-18
JP2023527678A (ja) 2023-06-30
US20230183221A1 (en) 2023-06-15
KR20230013101A (ko) 2023-01-26
BR112022023732A2 (pt) 2022-12-20
CN115667247B (zh) 2024-04-12

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