CN115624589B - Traditional Chinese medicine composition for resolving depression and soothing nerves as well as pharmaceutical preparation and application thereof - Google Patents
Traditional Chinese medicine composition for resolving depression and soothing nerves as well as pharmaceutical preparation and application thereof Download PDFInfo
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Abstract
The invention provides a traditional Chinese medicine composition for resolving depression and soothing nerves, which is prepared from the following raw materials in parts by weight: 5-25 parts of lavender, 20-40 parts of platycladi seed, 5-25 parts of schizonepeta, 20-40 parts of grassleaf sweelflag rhizome and 50-70 parts of Chinese angelica. The invention also provides a traditional Chinese medicine composition for resolving depression and soothing nerves, and a pharmaceutical preparation and application thereof. The advantages are that: the medicine is prepared from pure traditional Chinese medicines, based on the sufficient Chinese medicine and Western medicine theory, the sleep disorder is not only diagnosed and diagnosed for the description of the symptoms, but also focuses on the disease background of the whole disease and the pathogenesis of the disease, and the root of the disease is deepened. The traditional Chinese medicine composition has obvious curative effect, few raw material components, rich and easily obtained raw material components, simple preparation process and suitability for popularization and use. The volatile oil in the medicinal materials can improve sleep, and has the effects of balancing yin and yang, opening striae, smoothing lung and defensive qi, and regulating viscera function.
Description
[ field of technology ]
The invention relates to the technical field of traditional Chinese medicines, in particular to a traditional Chinese medicine composition for resolving depression and soothing nerves, a pharmaceutical preparation and application thereof.
[ background Art ]
Sleep disorders are often caused by long-term thought contradiction or mental overload, mental work, improper working and escape combined with long-term treatment, weakness after illness, and the like. Generally, four general categories are defined: 1. difficulty in initiating and maintaining sleep (insomnia); 2. excessive daytime sleepiness (somnolence); 3.24 hours sleep-wake cycle disorder (sleep-wake rhythm disorder); 4. abnormal activities and behaviors during sleep (sleep disorder, night terrors, nightmares).
Investigation has shown that adults have a proportion of sleep disorders up to 35% and the elderly over 60 years old have a proportion of sleep disorders of 27% -50% in some cities in children 2-6 years old. Furthermore, pregnant women may have a rate of up to 75% of sleep disorders at the end of gestation. Some stroke, parkinson's disease, diabetes and psychotic patients also experience varying degrees of sleep disorder, with 55.5% of the patients experiencing varying degrees of social dysfunction.
Sleep disorders are among the most common among them as insomnia. Insomnia (insomnia) is a subjective experience that affects daytime social functions by failing to meet normal physiological needs in terms of sleep quality or quantity due to sleep and/or sleep maintenance difficulties, and is the most common sleep disturbance disorder. Today, the acceleration of social rhythm and the aggravation of competition, insomnia is a very common phenomenon. The prevalence rate of insomnia is very high, the prevalence rate of countries such as Europe and America is about 20% -30%, and the prevalence rate of countries such as Europe and America is about 10% -20%. This difference in prevalence is related to the different individual demands for quality of life and subjective experiences, and there is no relevant epidemiological data in our country. Insomnia can cause inattention, hypomnesis, impaired judgment and daily work, and severe cases with anxiety, compulsions and depression.
Especially for naval vessel officers and soldiers, due to factors such as small personal space, large working pressure, moist climate, noisy environment and the like, the sleeping state is easy to influence, and sleeping disorder is easy to occur, so that various negative moods such as anxiety, depression and the like can be induced. Feng Chenxi [1] And the anxiety and depression emotion in the long voyage of sea crews mainly in young and strong years are obviously higher than those before voyage, and the sleep quality also can influence the survival quality of officers and soldiers, so that the quality of training, duty and other tasks is not facilitated. Recent research evidence suggests that insomnia is an important risk factor for post-traumatic stress disorder, depression, and anxiety disorder after military combat mission is performed by soldiers [2] During the sea going training of ships, the sleeping quality of officers and soldiers is improved, and normal training is not disturbed. However, the conventional hypnotizing mode by means of medicines is extremely easy to produce side effects, tolerance and dependence can be produced after long-term taking of medicines, withdrawal symptoms can be produced after stopping taking medicines, and therefore the long-term taking of medicines is not suitable.
In order to overcome the above-mentioned drawbacks, the positive idea meditation is a hot spot for researching non-drug treatment of sleep disorder in recent years, and many researches have proved that the positive idea is toHas good curative effect on chronic insomnia. Black etc [3] In a randomized controlled clinical trial, it was found that: the reduction in the pittsburgh sleep quality index was more pronounced in subjects taking part in meditation training than in the control group receiving sleep hygiene education. Domestic Wang Xiaoming, etc [4] Studies have found that positive-sense meditation levels and sleep quality of subjects show a significant positive correlation, and meditation training can effectively improve sleep quality by reducing anxiety levels of subjects. However, the effect of positive training is affected by experience and technology of therapists, foreign excessive syndrome documents can mention training qualification of positive trainers when reporting positive therapeutic effects, and most of domestic documents at present do not mention qualification and training experience of trainers, which may be a defect of positive meditation in practical application, so that clinical popularization is difficult.
Western medicine treatment mainly comprises insomnia, and common hypnotics are tranquilizer, such as short-acting alprazolam, medium-acting tranquilizer and sulbactam, and long-acting chlordiazepoxide; western medicine is improved but not fully controlled for most patients. Has limited curative effect on part of patients with difficult treatment, is easy to relapse after stopping the medicine, and has obvious side effect of western medicines.
Chinese patent document CN:201410818392.2, publication day 2015, 4 and 29, discloses a traditional Chinese medicine health care pillow, which comprises the following raw materials in parts by weight: 3-5 parts of albizia julibrissin, 2.5-4.5 parts of albizia julibrissin flower, 2-4 parts of platycladi seed, 1-3 parts of polygala tenuifolia, 1-2 parts of caulis polygoni multiflori, 1-2 parts of ganoderma lucidum, 2-4 parts of liquorice, 2-3 parts of schisandra chinensis, 2-4 parts of peanut leaf, 3-6 parts of chrysanthemum, rose, cassia twig and mimosa, and 2-5 parts of pine needle, heart nourishing grass, lavender and schizonepeta. The results prove that the traditional Chinese medicine composition has the effects of health care, sleep aiding and physical and mental pleasure.
Chinese patent document CN:201710392880.5, publication date 2017, 10 month and 10 day, discloses a compound essential oil composition for promoting sleep, and a preparation method and application thereof, and the compound essential oil composition comprises the following raw materials in parts by weight: 5-20 parts of sandalwood essential oil, 0.01-3 parts of amber essential oil, 5-20 parts of milk essential oil, 1-10 parts of rose essential oil, 5-40 parts of lavender essential oil and 5-40 parts of sweet orange essential oil. The results prove that the traditional Chinese medicine composition can effectively improve insomnia and has the effects of calming, helping sleep and soothing the nerves.
Such traditional Chinese medicine compositions for resolving depression and soothing nerves have many but more or less disadvantages, such as excessive medicine taste, difficult material acquisition, high price, insignificant medicine effect and the like. Therefore, a traditional Chinese medicine composition with obvious depression relieving and nerve soothing effects, moderate medicine taste and convenient preparation is needed.
[ invention ]
The invention aims at overcoming the defects in the prior art and provides a traditional Chinese medicine composition for resolving depression and soothing nerves.
In a first aspect, the invention provides a traditional Chinese medicine composition for resolving depression and soothing nerves, which is prepared from the following raw materials in parts by weight: 5-25 parts of lavender, 20-40 parts of platycladi seed, 5-25 parts of schizonepeta, 20-40 parts of grassleaf sweelflag rhizome and 50-70 parts of Chinese angelica;
as a preferred example of the invention, the traditional Chinese medicine composition is prepared from the following raw materials in parts by weight: 10-20 parts of lavender, 25-35 parts of platycladi seed, 10-20 parts of schizonepeta, 25-35 parts of grassleaf sweelflag rhizome and 55-65 parts of Chinese angelica;
as another preferred example of the invention, the traditional Chinese medicine composition is prepared from the following raw materials in parts by weight: 15 parts of lavender, 30 parts of platycladi seed, 15 parts of schizonepeta, 30 parts of grassleaf sweelflag rhizome and 60 parts of Chinese angelica.
As another preferred example of the invention, the preparation method of the traditional Chinese medicine composition comprises the following steps: grinding Lavender, semen Platycladi, herba Schizonepetae, rhizoma Acori Graminei, and radix Angelicae sinensis into powder, mixing with the volatile oil, and packaging into sachet
In a second aspect, the present invention provides a pharmaceutical preparation comprising the depression-relieving and tranquillizing Chinese medicinal composition as an active ingredient.
As a preferred example of the present invention, the pharmaceutical preparation is a powder, and further comprises volatile oil derived from a mixture of any one or more of the above-mentioned Chinese medicinal compositions.
In a third aspect, the invention provides the use of a Chinese medicinal composition as defined in any one of the above in the preparation of a medicament for the treatment/alleviation of sleep disorders.
As a preferred example of the present invention, the sleep disorder is anxiety or depression.
Monarch, minister, assistant and guide:
the platycladi seed has flat property without cold or dryness, sweet and tonifying, is pungent and moist, has delicate fragrance, can permeate heart and kidney and benefit spleen and stomach, and is covered with the medicine, and takes the effects of nourishing blood and tranquillizing as principal drugs; rhizoma Acori Graminei, for patients with deficiency of heart-qi, is used for invigorating qi; taking the functions of refreshing mind and improving intelligence, the Chinese angelica and the Chinese angelica are taken together as ministerial drugs, and the auxiliary monarch drug platycladi seed has the functions of nourishing blood and tranquillizing. Herba schizonepetae, fragrant and warm, can promote the circulation of qi and blood and nourish blood and tranquilize mind, and is an adjuvant drug; lavender has fragrant smell, can promote the circulation of qi and relieve depression, and has the effects of promoting circulation and relieving depression, and auxiliary monarch and minister medicines are used for promoting qi and blood circulation, relieving Yu Jie and releasing mind; dang Gui has the actions of nourishing blood and tonifying blood, and zornia arborvitae seed has the actions of nourishing blood and tranquillizing.
The medicines are combined to promote qi and blood circulation, relieve Yu Jie and calm heart, and supplement each other, so that the medicine has the effects of supplementing and dispersing, nourishing and promoting blood circulation, nourishing blood and tranquillizing, but not greasy, promoting qi and blood circulation, resolving depression and tranquillizing.
The invention has the advantages that:
the invention relates to a traditional Chinese medicine composition for resolving depression and tranquillizing, which refers to ancient prescription and refers to the progress of modern pharmacological research, and is prepared by grinding medicinal materials such as grassleaf sweelflag rhizome, platycladi seed, fineleaf schizonepeta herb, chinese angelica, lavender and the like into powder, and the effect of improving sleep treatment is achieved through volatile oil in the medicinal materials. Modern pharmacological researches have proved that rhizoma Acori Graminei, semen Platycladi, radix Angelicae sinensis and Lavender have sedative and hypnotic effects, and that catmint oil has phlegm eliminating effect, and can relieve the irritation of humid gas environment in a closed cabin to the respiratory tract of officers and soldiers, and by reasonably adjusting the proportion of traditional Chinese medicines, the effects of smoothing lung and defensive, relieving Yu Qingxin, soothing the nerves and helping sleep can be achieved.
[ detailed description ] of the invention
The following provides a detailed description of specific embodiments of the invention.
Example 1 preparation of Chinese medicinal composition for resolving Depression and tranquillizing
15 parts of lavender, 30 parts of platycladi seed, 15 parts of schizonepeta, 30 parts of grassleaf sweelflag rhizome and 60 parts of Chinese angelica, and is prepared into a traditional Chinese medicine sachet.
Example 2 preparation of Chinese medicinal composition for resolving Depression and tranquillizing (II)
15 parts of lavender, 25 parts of platycladi seed, 20 parts of schizonepeta, 20 parts of grassleaf sweelflag rhizome and 70 parts of Chinese angelica, and is prepared into a traditional Chinese medicine sachet.
Example 3 preparation of Chinese medicinal composition for resolving Depression and tranquillizing
10 parts of lavender, 35 parts of platycladi seed, 5 parts of schizonepeta, 40 parts of grassleaf sweelflag rhizome and 60 parts of Chinese angelica, and is prepared into a traditional Chinese medicine sachet.
Example 4 preparation of a Chinese medicinal composition for resolving Depression and tranquillizing (IV)
20 parts of lavender, 20 parts of platycladi seed, 25 parts of schizonepeta, 30 parts of grassleaf sweelflag rhizome and 55 parts of Chinese angelica, and preparing the traditional Chinese medicine sachet.
Example 5 preparation of a Chinese medicinal composition for resolving Depression and tranquillizing (fifth)
5 parts of lavender, 40 parts of platycladi seed, 15 parts of schizonepeta, 25 parts of grassleaf sweelflag rhizome and 65 parts of Chinese angelica, and preparing the traditional Chinese medicine sachet.
Example 6 preparation of a Chinese medicinal composition for resolving Depression and tranquillizing (six)
25 parts of lavender, 30 parts of platycladi seed, 10 parts of schizonepeta, 35 parts of grassleaf sweelflag rhizome and 50 parts of Chinese angelica, and is prepared into the traditional Chinese medicine sachet.
Example 7 preparation of a Chinese medicinal composition for resolving Depression and tranquillizing (seventh)
15 parts of lavender, 35 parts of platycladi seed, 5 parts of schizonepeta, 40 parts of grassleaf sweelflag rhizome and 60 parts of Chinese angelica, and is prepared into a traditional Chinese medicine sachet.
Example 8 preparation of a Chinese medicinal composition for resolving Depression and tranquillizing (eight)
10 parts of lavender, 20 parts of platycladi seed, 25 parts of schizonepeta, 30 parts of grassleaf sweelflag rhizome and 55 parts of Chinese angelica, and is prepared into a traditional Chinese medicine sachet.
Example 9 preparation of a Chinese medicinal composition for resolving Depression and tranquillizing (nine)
20 parts of lavender, 40 parts of platycladi seed, 15 parts of schizonepeta, 25 parts of grassleaf sweelflag rhizome and 65 parts of Chinese angelica, and is prepared into a traditional Chinese medicine sachet.
Example 10 preparation of a Chinese medicinal composition for resolving Depression and tranquillizing (ten)
5 parts of lavender, 30 parts of platycladi seed, 10 parts of schizonepeta, 35 parts of grassleaf sweelflag rhizome and 50 parts of Chinese angelica, and is prepared into a traditional Chinese medicine sachet.
Example 11 preparation of Chinese medicinal composition for resolving Depression tranquillizing (eleven)
25 parts of lavender, 25 parts of platycladi seed, 20 parts of schizonepeta, 20 parts of grassleaf sweelflag rhizome and 70 parts of Chinese angelica, and is prepared into the traditional Chinese medicine sachet.
The traditional Chinese medicine sachet is prepared by grinding lavender, platycladi seed, schizonepeta, grassleaf sweelflag rhizome and Chinese angelica into powder according to a certain proportion, mixing the powder with volatile oil uniformly, and packaging the mixture into sachets.
Example 12 clinical trials
1. Preparation of traditional Chinese medicine sachet for relieving depression and soothing nerves
Mixing Lavender 15 weight parts, semen Platycladi 30 weight parts, herba Schizonepetae 15 weight parts, rhizoma Acori Graminei 30 weight parts, and radix Angelicae sinensis 60 weight parts, mixing with the volatile oil, and packaging into bags to obtain traditional Chinese medicine sachet.
2. Object and method
2.1 study object
Officials 59 people with sleep disorder (PSQI score of Pittsburgh sleep quality index scale is more than or equal to 8 and SAS score of anxiety score scale is more than or equal to 50) are screened out 1 week before sea training of naval army, and the naval army has no mental diseases and allergic constitution.
2.2 grouping
The experimental group of sachets was randomly divided into 20 persons, the positive thought meditation group 20 persons and the blank group 19 persons. The selected officers and soldiers are men, and the comparison difference has no statistical significance (P is more than 0.05) in the aspects of age, academic, marital, post, personnel quality and the like. There was no statistical difference between the PSQI scores and the SAS scores before treatment for the three officials and soldiers, and the scores were comparable.
2.3 Experimental methods
The experimental group uses self-made traditional Chinese medicine sachet (grassleaf sweelflag rhizome, platycladi seed, chinese angelica, fineleaf schizonepeta herb and lavender) for resolving depression and soothing nerves. The sachet is placed at the bed head, the sachet is opened before sleeping at night, the nose and mouth are placed at a distance of about ten centimeters from the sachet mouth, the sachet is deeply smelled for 3 minutes, the sachet is replaced for officers and soldiers every 2 weeks, and the treatment is carried out for 8 weeks.
The positive idea meditation training mainly refers to the eight-week course structure of positive idea cognitive therapy (V.West, williams Mark, tim Stokes John. Internal cognitive therapy of depression, beijing company of world book publishing company, 2008), and is intensively trained 1 time per week under guidance audio guidance, each time for 2 hours, including training and experience sharing, and the rest of time is trained by self according to post-class operation.
The blank control group keeps the same work and rest as the sachet experimental group and the positive idea meditation group, and works. The differences in PSQI and SAS scores before and after treatment were statistically compared in three groups.
3. Observation index
PSQI scale scores, total score > 8 indicating sleep disorder, higher score indicating more severe sleep disorder. Efficacy evaluation criteria: and evaluating according to the PSQI score reduction rate of the Pittsburgh sleep quality index scale.
(1) And (3) healing: the PSQI score reduction rate is above 75%;
(2) The effect is shown: the PSQI score reduction rate is between 50% and 74%;
(3) The method is effective: the PSQI score reduction rate is 25-49%;
(4) Invalidation: the PSQI score reduction rate is within 25%.
SAS scale score <50 score no anxiety, > 50 score mild anxiety, > 60 score moderate anxiety, and > 70 score severe anxiety.
4. Statistical method
Statistical analysis of the data was performed using SPSS21.0 software, and the metrology data was expressed as mean.+ -. Standard deviation (x.+ -. S). The difference between the three groups of PSQI scores and the SAS score is tested by adopting single factor analysis of variance and SNK, and all tests take P <0.05 as a test standard.
5. Analysis of results
Results of scoring conditions of the PSQI and SAS scales before and after the experiment of the three experimental groups are shown in Table 1:
table 1 scoring Condition (score, X.+ -. S) of PSQI and SAS scales before and after three official experiments
The PSQI score differences and SAS score differences for the three experimental groups are shown in tables 2 and 3:
TABLE 2PSQI score difference (front-rear) Student-Newman-Keuls a,b
TABLE 3SAS scoring Difference (front-rear) Student-Newman-Keuls a,b
The total efficacy of the PSQI scoring treatment for the three experimental groups is summarized in table 4:
TABLE 4 total efficacy of PSQI scoring treatment (%)
In the experimental process, three groups of experimental officials and soldiers can adhere to the treatment project, and no obvious adverse reaction occurs during the treatment period.
According to the results, the scores of PSQI and SAS of a blank control group are increased to different degrees, the scores of officials and soldiers of a positive idea meditation group and a sachet experiment group, the efficacy ratings of the PSQIs and the scores of SAS are reduced to different degrees, and the scores of two scales of officials and soldiers of three groups are subjected to variance analysis, wherein P is less than 0.05, and the difference is statistically significant. The SNK test shows that the sachet experimental group and the positive-sense meditation group have equivalent functions in reducing the PSQI and SAS scores, and the reduction degree has no statistical difference.
Therefore, the depression-relieving and nerve-soothing traditional Chinese medicine sachet has obvious curative effect in treating sleep disorder and improving sleep quality, is simple, practical, safe and effective, is convenient to use, has no obvious adverse reaction in the treatment process, has the advantages of simplicity and low cost, is a practical and effective method for improving the sleep disorder of the naval vessel officers and soldiers, and is also suitable for improving the sleep disorder in daily life.
Example 13 animal experiments
1 Experimental materials
1.1 animals
Rats, 50, body weight 220-250g, purchased from Shanghai Sipuler-BiKai laboratory animal Co. All rats were fed free diet and 1 week of habitual feeding, and weighed mass. The experimental animals are group-cultured in ventilation cages, 5 animals are kept in each cage, the temperature of the raising room is 25 ℃, the humidity is 35-60%, the animals can eat food freely, and the circadian rhythm is carried out according to 12h for light and 12h for dark.
1.2 medicaments
The preparation method of the traditional Chinese medicine composition comprises the following steps: 15 parts of lavender, 30 parts of platycladi seed, 15 parts of schizonepeta, 30 parts of grassleaf sweelflag rhizome and 60 parts of Chinese angelica, and is prepared into a traditional Chinese medicine sachet (the lavender, platycladi seed, schizonepeta, grassleaf sweelflag rhizome and Chinese angelica are ground into powder according to a certain proportion, and are uniformly mixed with volatile oil and are respectively filled into the sachet).
The preparation method of the traditional Chinese medicine composition II comprises the following steps: 5 parts of lavender, 40 parts of platycladi seed, 15 parts of schizonepeta, 25 parts of grassleaf sweelflag rhizome and 65 parts of Chinese angelica.
Control group preparation: 5 parts of lavender, 40 parts of platycladi seed, 15 parts of cassia twig, 25 parts of storax and 65 parts of Chinese angelica.
Western medicine group: diazepam (0.03 g/kg).
Model group: physiological saline.
1.3 major instrumentation
Electric shock cage, ventilation cage, one-way contact type alternating current voltage regulator (Zhejiang power supply equipment limited company).
2 method
2.1 preparation of Insomnia animal model
The model is built by adopting a multi-condition fear method, rats are placed into electric shock cages, 5 rats are placed into each cage, and insomnia rats are built by adopting a method of associating negative stimulation (such as plantar electric shock) with neutral prompt (such as sound and illumination) or specific environment (experimental room) except normal feeding: firstly, placing a rat in an electric shock cage, adding used cat litter, exposing for 90min, and performing fear memory training; noise interference is then carried out, the intensity is generally 85-90 dB, and most of the used sounds are random combinations of noise with different properties, intensity and frequency, and can comprise traffic noise, alarm, music, artificial synthetic noise and the like. Then, 15V voltage is selected, and the current is supplied and the electric shock quantity is intermittent by 1:5, so that the rats are deprived of sleep time for 2.5 hours at random every day for 14 days. The arousal time of the rat is obviously increased, the sleep quality is reduced and the sleep rhythm is disturbed, namely the modeling is considered successful, otherwise the modeling is considered to be failed.
2.2 test protocol
The 50 rats were randomly divided into five groups, 10 in each of the inventive group I, inventive group II, control group, western medicine group and model group. By observing the weight change of rats, the group of the invention does not fall off; the weight of the second group of the invention does not reach the standard, and 1 case of the second group falls off; one body weight of the control group does not reach the standard, and the other body weight exceeds the standard, and 2 cases of falling off; the western medicine group body weight exceeds standard, and 1 case of western medicine is dropped; the model group is free from falling off.
The treatment (opening the sachet before sleeping, the rats sniff for 30min each day, replacing the sachet for every 1 week, and treating for 4 weeks) of the invention group and the control group respectively, the western medicine group and the model group were subjected to gastric lavage treatment. Daily observation and recording body surface characteristics of each group of rats; after the completion, the rat is sacrificed by head breaking, the skull is removed, the brain tissue is completely exposed, the medulla oblongata is rapidly sheared at the occipital bone macropore, the brain tissue is taken out, the brain and cerebellum are removed, and the weight is carried out. The absorbance of 5-HT, 5-HIAA, NA and DA of each sample of the model group is converted to mug/g by referring to simultaneous extraction and fluorescence spectrophotometry of 5-hydroxytryptamine, 5-oxindole acetic acid, norepinephrine and dopamine in brain tissue.
2.3 statistical methods
The counting data and the grade data are compared by Fisher accurate inspection; metering dataTo show, the comparison between groups uses one-factor analysis of variance (variance non-uniformityThe latter were tested using the Tam hanesT test). Statistical analysis, P, using GraphPadprism 8 software<0.05 is statistically significant.
2.4 results
2.4.1 body surface characteristics of rats before and after treatment
The rats in the group, the control group, the model group and the western medicine group have poor mental state, slow response, withered hair, obviously reduced drinking water, more stool and sometimes no formation before treatment. After four weeks of treatment, compared with a model group, rats in the group disclosed by the invention have good mental state, smooth and moist hair, active response, normal stool and normal drinking water. The western medicine group rats have smooth and glossy hair, are sensitive to irritation, are not easy to be irritated, and have normal defecation times. The control rats had slightly weaker mental states, sometimes irregular stool shape, and increased drinking water.
2.4.2 control of index content of rats 5-HT, 5-HIAA, NA, DA in groups (μg/g)
As can be seen from the comparison of the two compositions, after continuous administration to insomnia rats: the content of 5-HT in the first, second, control and western medicine groups is increased, but the first and second groups are obviously increased and are obviously different from the model group (P is less than 0.05); the 5-HIAA content of the first group and the second group of the invention is obviously increased compared with that of the model group, and the difference is obvious (P is less than 0.05); the first group and the second group of the invention can obviously reduce the NA content in brain tissues of insomnia rats, and are superior to a control group and a western medicine group (P is less than 0.05). The results of the dopamine content show that the DA content can be reduced by the first group and the second group of the invention, which is superior to the control group and the western medicine group (P is less than 0.05). See Table 5
Table 5 controls of index levels (. Mu.g/g) for rats of each group 5-HT, 5-HIAA, NA, DA
Note that: comparison with model group 1) (P<0.05 A) is provided; comparison with the control group 2) (P<0.05 A) is provided; comparison with Western medicine group 3) (P<0.05)。
The foregoing is merely a preferred embodiment of the present invention, and it should be noted that modifications and additions may be made to those skilled in the art without departing from the method of the present invention, which modifications and additions are also to be considered as within the scope of the present invention.
Reference to the literature
【1】 Feng Chenxi, gu Xiaodi, zhu Yaqin. Preliminary investigation of psychological and physiological responses of sea crews in ocean voyage [ J ]. J.China journal of navigation medicine, 1995,2 (1): 52.
【2】Gehrman P，SeeligAD，JacobsonIG，eta1.Predeployment sleep durati on and insomnia symptoms as risk factors for newonsetmental health disorders following military deployment[J].Sleep，2013，36(7)：1009—1018。
【3】Black DS，O’Reilly GA，Olmstead R，eta1.Mindfulness meditation and improvement in sleep quality and daytime impairment among older adults with sleep disturbances：a randomized clinical trial[J].JAMA Intern Med，2015，175(4)：494-501。
【4】 Influence and mechanism of positive-sense decompression training on sleep quality of participants [ D ]. Beijing: university of capital, university 2014.
Claims (5)
1. The traditional Chinese medicine composition for resolving depression and soothing nerves is characterized by being prepared from the following raw materials in parts by weight: 5-25 parts of lavender, 20-40 parts of platycladi seed, 5-25 parts of schizonepeta, 20-40 parts of grassleaf sweelflag rhizome and 50-70 parts of Chinese angelica.
2. The traditional Chinese medicine composition according to claim 1, which is characterized by being prepared from the following raw materials in parts by weight: 10-20 parts of lavender, 25-35 parts of platycladi seed, 10-20 parts of schizonepeta, 25-35 parts of grassleaf sweelflag rhizome and 55-65 parts of Chinese angelica.
3. The traditional Chinese medicine composition according to claim 2, which is characterized by being prepared from the following raw materials in parts by weight: 15 parts of lavender, 30 parts of platycladi seed, 15 parts of schizonepeta, 30 parts of grassleaf sweelflag rhizome and 60 parts of Chinese angelica.
4. Use of a traditional Chinese medicine composition according to any one of claims 1-3 for preparing a medicament for treating/alleviating sleep disorders.
5. The use according to claim 4, wherein the sleep disorder is anxiety, depressive disorder.
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Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101084947A (en) * | 2007-06-21 | 2007-12-12 | 张家港市晓阳食品有限公司 | Sedative tea containing semen platycladi and angelica sinensis |
| CN101632761A (en) * | 2008-11-22 | 2010-01-27 | 中山市中南烛业有限公司 | Nerves-soothing compound oil, essential oil of traditional Chinese medicine and aromatherapy products having nerves-soothing function |
| CN105560664A (en) * | 2016-03-17 | 2016-05-11 | 黄晓其 | Pharmaceutical composition with tranquilizing effect and preparation method and application of pharmaceutical composition |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN101084947A (en) * | 2007-06-21 | 2007-12-12 | 张家港市晓阳食品有限公司 | Sedative tea containing semen platycladi and angelica sinensis |
| CN101632761A (en) * | 2008-11-22 | 2010-01-27 | 中山市中南烛业有限公司 | Nerves-soothing compound oil, essential oil of traditional Chinese medicine and aromatherapy products having nerves-soothing function |
| CN105560664A (en) * | 2016-03-17 | 2016-05-11 | 黄晓其 | Pharmaceutical composition with tranquilizing effect and preparation method and application of pharmaceutical composition |
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| 景衣安神散穴位贴敷治疗失眠临床观察;乔飞;胡晓灵;胡金霞;;山西中医;-;第26卷(第04期);全文 * |
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