CN107362289B

CN107362289B - Anti-depression incense and preparation method thereof

Info

Publication number: CN107362289B
Application number: CN201710332560.0A
Authority: CN
Inventors: 梁德成
Original assignee: Guangdong Yuecheng Technology Co Ltd
Current assignee: Guangdong Yuecheng Technology Co., Ltd
Priority date: 2017-05-12
Filing date: 2017-05-12
Publication date: 2021-03-30
Anticipated expiration: 2037-05-12
Also published as: CN107362289A

Abstract

The invention discloses an antidepressant incense and a preparation method thereof, and the raw material formula comprises 55-65% of camphorwood powder, 5-10% of 90470 antidepressant essential oil, 28-36% of wood sticking powder and 1-2% of potassium nitrate; wherein the 90470 formula of the antidepressant essential oil comprises 18-22% of lavender oil, 27-33% of citronella oil, 18-22% of pure cinnamomum camphora leaf oil, 9-11% of litsea cubeba oil and 18-22% of benzoin cream. The preparation method comprises the following steps of preparing materials; mixing lignum Cinnamomi Camphorae leaf powder with 90470 antidepressant essential oil, kneading, adding viscous wood powder and potassium nitrate, and stirring; putting the uniformly stirred raw materials into a stirrer, adding water and stirring to prepare slurry; and (5) pressing and forming. The natural camphor wood powder is adopted, 90470 antidepressant essential oil and other raw materials are added, and the prepared antidepressant incense smells the fragrance in a natural breathing mode, directly relieves the mind of the brain of a patient, gives people a calm, comfortable and warm feeling, has good curative effect on depression patients, and has no side effect.

Description

Anti-depression incense and preparation method thereof

Technical Field

The invention relates to the technical field of health care and medical treatment, in particular to an anti-depression therapeutic substance and a preparation method thereof.

Background

According to the data of the world health organization, the depression is only second to the major diseases such as AIDS, heart disease and the like, and is positioned in the 5 th position in the ten diseases worldwide, thus seriously affecting the life quality of people. At present, 3.5 million people worldwide suffer from depression, and the annual prevalence rate of depression worldwide is about 11%. The prevalence rate of various mental diseases in China exceeds 1 hundred million people, the prevalence rate of depression reaches 3% -5%, about 4000 million people are treated, only 10% of the patients seek help, and the condition is not optimistic. Common treatments for depression are: the drug therapy is the most extensive and relatively better.

However, the existing antidepressant drugs can stimulate the stomach and also have adverse effects on the immune system of a human body, so that a plurality of side effects are brought to people, such as dizziness, nausea, hypertension, constipation and the like, and excessive drugs can cause acute poisoning and even death, so that the existing drug therapy for depression has a great risk.

Disclosure of Invention

The invention aims to solve the technical problem of providing the antidepressant incense with good curative effect, safety, reliability, small side effect and simple preparation method and the preparation method thereof.

In order to solve the technical problems, the invention adopts the following technical scheme: an anti-depression incense which is characterized in that: the formula of the raw materials comprises, by weight, 55-65% of camphorwood powder, 5-10% of 90470 antidepressant essential oil, 28-36% of wood sticking powder and 1-2% of potassium nitrate; wherein the 90470 formula of the antidepressant essential oil comprises, by weight, 18-22% of lavender oil, 27-33% of citronella oil, 18-22% of pure cinnamomum camphora leaf oil, 9-11% of litsea cubeba oil and 18-22% of benzoin paste.

Among the above raw materials, lavender oil: the lavender essential oil extracted by distillation from the flowers/stems of lavender is a well-known wild essential oil, can be used for any skin, can be used for bathing, can be dripped on a pillow to help sleep, can massage the head and can be used as body fragrance to calm the mood, has unique fragrance, has a good nerve calming effect, and helps to improve the sleep quality.

Citronella oil: the extract is obtained by distillation from Cymbopogon citratus plant, and has antidepressant, antibacterial, insecticidal, body tonifying, and exciting effects; can purify and enhance emotion, and relieve depression.

Pure cinnamomum camphora leaf oil: the method adopts a systematic solvent method to prepare a series of anticancer ethanol extracts from pure cinnamomum camphora leaf fragrance, and has the effects of resisting inflammation and resisting cancer.

Litsea cubeba oil: the citral raw material in the flowers, leaves and fruit peels is mainly extracted, and the citral raw material has the effects of warming the kidney, invigorating the stomach, promoting the circulation of qi and resolving hard mass.

Benzoin paste: the benzoin resin has the effects of inducing resuscitation, refreshing mind, promoting qi and blood circulation, and relieving pain.

Preferably, the camphor wood powder is 100-mesh camphor leaf wood powder.

The preparation method of the depression-inhibiting incense is characterized by comprising the following steps: the method comprises the following steps of (1),

1) preparing materials, namely preparing the following raw materials in parts by weight: 55-65% of camphor wood powder, 5-10% of 90470 antidepressant essential oil, 28-36% of sticky wood powder and 1-2% of potassium nitrate; wherein the 90470 formula of the antidepressant essential oil comprises, by weight, 18-22% of lavender oil, 27-33% of citronella oil, 18-22% of pure cinnamomum camphora leaf oil, 9-11% of litsea cubeba oil and 18-22% of benzoin paste;

2) blending, namely taking 100-mesh camphor leaf wood powder, adding 90470 anti-depression essential oil, mixing uniformly, then respectively adding the viscose wood powder and potassium nitrate according to the proportion, and stirring uniformly;

3) mixing materials, namely putting the uniformly stirred raw materials into a stirrer, then adding water, and stirring to prepare uniform viscous slurry;

4) and forming, namely pressing and forming the slurry, and drying to obtain the depression-inhibiting fragrance. Can be made into various shapes such as line incense, coil incense, stick incense and incense granule.

Further, in the step 3), the adding amount of water is 8-12 times of the weight of the 90470 antidepressant essential oil, the stirring time is 20-40 minutes, the stirring time determines the quality of the fragrance, so that the raw materials are uniformly colored without color change or damage to the viscosity and fragrance of the fragrance, the state of the raw materials needs to be noticed in the material stirring process, the water content needs to be properly adjusted, the materials are too dry and easy to break and too wet and easy to deform, and the water amount can be properly stirred and then uniform.

Further, in the forming procedure of the step 4), firstly, the bamboo sticks are primed when making the stick incense, firstly, the wood sticking powder for priming is put into an incense making machine, the bamboo sticks are selected and watered, then the bamboo sticks are put into the incense making machine, the incense making machine is started, the machine is stopped after 60 to 90 seconds, and the padding blanks after priming are taken out; then the operation of applying the inner powder and the upper skin powder is carried out.

The invention is developed by adopting natural camphor wood powder and adding 90470 anti-depression essential oil and other raw materials, the 90470 anti-depression essential oil is prepared by adopting natural lavender oil, citronella oil, pure camphor leaf oil, litsea cubeba oil, benzoin cream and other raw materials, the prepared anti-depression fragrance (also called forgetful fragrance) smells the fragrance in a natural breathing mode, directly enables the brain of a patient to be mentally relieved, gives people calm, comfortable and warm feelings, has good curative effect on depression patients, does not bring side effects to the patients caused by long-term medicine taking, is safe and reliable, has a simple preparation method, and is beneficial to reducing the medicine cost.

Detailed Description

The invention will be further illustrated by the following specific embodiments,

in the embodiment 1, the formula of the anti-depression incense comprises 65 jin of camphorwood powder, 8 jin of 90470 anti-depression essential oil, 35 jin of viscose wood powder and 1 jin of potassium nitrate; wherein the 90470 formula of the antidepressant essential oil comprises, by weight, 18% of lavender oil, 33% of citronella oil, 22% of pure cinnamomum camphora leaf oil, 9% of litsea cubeba oil and 18% of benzoin paste.

The camphor wood powder is 100-mesh camphor leaf wood powder.

The preparation method of the depression-inhibiting incense is carried out according to the following steps,

1) preparing raw materials;

3) mixing materials, namely putting the uniformly stirred raw materials into a stirrer, adding 80 jin of water, and stirring to prepare uniform viscous slurry;

In the step 3), the stirring time is 20-40 minutes after water is added, so that the raw materials are uniformly colored without color change and the viscosity and fragrance of the spice are not damaged, and the raw material state is required to be noticed in the material stirring process, the water content is properly adjusted, the material is too dry and easy to break, the material is too wet and easy to deform, and the water content is properly stirred to be uniform.

In addition, in the molding process, if the stick incense is manufactured, firstly, the bamboo sticks are primed, firstly, the wood sticking powder for priming is put into an incense making machine, the bamboo sticks are selected and watered, then the incense is put into the incense making machine, the incense making machine is started, the machine is stopped after 60 to 90 seconds, and the padding blanks after priming are taken out; then the operation of applying the inner powder and the upper skin powder is carried out.

Example 2 is different from example 1 in that the raw material formulation of the anti-depression incense is as follows, 55 jin of camphorwood powder, 10 jin of 90470 anti-depression essential oil, 28 jin of viscose wood powder and 1 jin of potassium nitrate; the 90470 formula of the antidepressant essential oil comprises, by weight, 22% of lavender oil, 27% of citronella oil, 22% of pure cinnamomum camphora leaf oil, 9% of litsea cubeba oil and 20% of benzoin cream. When water is added to prepare a viscous slurry, the addition amount of the water is 80 jin.

55-65% of the total weight of the composition, 5-10% of 90470 antidepressant essential oil, 28-36% of wood sticking powder and 1-2% of potassium nitrate; wherein the 90470 formula of the antidepressant essential oil comprises, by weight, 18-22% of lavender oil, 27-33% of citronella oil, 18-22% of pure cinnamomum camphora leaf oil, 9-11% of litsea cubeba oil and 18-22% of benzoin paste;

example 3 is different from example 1 in that the raw material formulation of the anti-depression incense is as follows, 60 jin of camphorwood powder, 8 jin of 90470 anti-depression essential oil, 36 jin of viscose wood powder and 2 jin of potassium nitrate; the 90470 formula of the antidepressant essential oil comprises, by weight, 20% of lavender oil, 30% of citronella oil, 20% of pure cinnamomum camphora leaf oil, 10% of litsea cubeba oil and 20% of benzoin paste. When water is added to prepare a viscous slurry, the addition amount of water is 96 jin.

Example 4 is different from example 1 in that the raw material formulation of the anti-depression incense is as follows, 65 jin of camphorwood powder, 8 jin of 90470 anti-depression essential oil, 36 jin of viscose wood powder and 1.5 jin of potassium nitrate; the 90470 formula of the antidepressant essential oil comprises, by weight, 20% of lavender oil, 30% of citronella oil, 18% of pure cinnamomum camphora leaf oil, 11% of litsea cubeba oil and 21% of benzoin cream. When water is added to prepare a viscous slurry, the addition amount of the water is 90 jin.

The antidepressant aroma efficacy test and evaluation summary:

test protocol:

design of experimental scheme

1. Olfaction preference test of different kinds of fragrance for resisting depression fragrance

1.1 fragrance concentration test

1.1.1 test materials: four-number solid incense

1.1.2 test sites: aromatic plant research and development center of Shanghai university of transportation

1.1.3 test methods: the testee smells the incense in a closed room for 30 min. And finally, finishing the aroma evaluation table.

The test is carried out in four times, only one formula is tested each time, and each numbered incense corresponds to about 60-80 persons respectively. The purpose of this experiment is to select the concentration, so the evaluation table 2 is the main data statistical object, where A, B, C, D corresponds to the concentrations: 2%, 4%, 6% and blank incense.

1.2 fragrance-smelling preference test

1.2.1 test materials: four-number solid incense

1.2.3 test methods: the testee smells the incense in a closed room for 30 min. And finally, finishing the aroma evaluation table.

Including preference, feeling after smelling fragrance, etc. Only one formulation was tested at a time, with about 90 out of each numbered incense for a total of 348.

2. Efficacy evaluation animal model test of different species of anti-depression incense

2.1 test subjects: kunming mouse, male 60. 2.2 test sites: shanghai university of traffic animal laboratory

2.3 test methods: the tail suspension experiment and forced swimming experiment are carried out. After suspending the tail or putting into water, the mice give up struggling, and show disappointed state in a discontinuous immobile or floating state.

Randomly dividing the mice into 6 groups, each group comprises 10 mice, and the mice are respectively 2 blank control groups; 2 non-perfuming coil smelling groups; 2 preferably perfumed coil sniffing groups. Feeding for 3d, and performing the experiment after smelling for 15min on 4 d. The fragrance smelling method comprises igniting the coil outside the room until the combustion is stable, placing into a fragrance smelling cage for animals, stably spreading fragrance for 15min, and placing into animals for fragrance smelling for 15 min. Animals were free to feed and drink during the experiment.

Mouse tail suspension experiment: the tail of the mouse is fixed by a clamp at a position about 1 cm away from the tail end, the tail of the mouse is hung upside down on a cross rod about 15 cm away from the ground, the sight of the mouse is isolated by a plate all around, the animal struggles and moves for overcoming abnormal body positions, but after the animal moves for a period of time, the animal is discontinuous and is in disappointed state, and the immobility time in each group of 6 min is accumulated.

Forced mouse swimming experiment: the mice were placed in a container of about 18 cm diameter, water depth 35cm, water temperature 25 ℃ and the time for the mice to float was determined within 5min (i.e., the mice stopped struggling in the water, or the animals were floating with only minor limb movements to keep the head floating on the water).

3. Brain wave test

3.1 materials and instruments

The formula is as follows: 90470 antidepressant formulation and 90472 antidepressant formulation.

Data acquisition was performed using a digital electroencephalograph (model ND-97, high tech medical instruments, shanghai).

3.2 test sites: brain wave testing room of aromatic plant research and development center of Shanghai university of transportation

3.3 brief introduction to digital electroencephalograph

The brain electricity is an electrophysiological signal generated by the electrical activity of the brain cortex nerve cell cluster, generally ranging from a few microvolts to hundreds of microvolts. The brain waves are composed of various rhythmic waves and are divided into delta waves, theta waves, alpha waves and beta waves according to different frequencies, and the frequencies of the delta waves, the theta waves, the alpha waves and the beta waves are 0.5-3.5 Hz respectively; 4.0-7.5 Hz; 8.0-13.5 Hz; 14.0 to 30.0 Hz. Alpha and beta waves belong to fast waves in brain waves; alpha waves are the normal waveform when an adult is awake and quiet closing the eyes, and beta waves occur when a person senses an external stimulus, is alert, or is subjected to a particular psychological stress. The delta and theta waves are slow waves in brain waves, and their components are increased during the sleep period of a normal adult. The occurrence and amplitude of each wave vary greatly among individuals, and are affected by factors such as age and sex.

3.4 electroencephalogram data acquisition

3.4.1 recruitment of volunteers

All volunteers in this study were recruited by voluntary roll-in, with 47 people co-recruited, from age 17 to 34 years, for the most students at school. Wherein 90470 groups had 25 people; 90472 the population is 22.

3.4.2 volunteer electroencephalogram data acquisition

The brain wave experiment is carried out in the electroencephalograph room of the aromatic plant research and development center of Shanghai university of transportation. The conventional indoor environment arrangement has the advantages that the surrounding environment is relatively quiet, and no obvious bad smell influence exists. The tested volunteers receive the brain wave test in a normal sitting posture mode and are connected with the electroencephalograph in a 16-lead human body potential mode. After the brain wave signals are led out by the scalp electrodes, the fast Fourier transform is carried out by the preamplifier and the central processing unit, the wave amplitude-time relation of the brain waves is converted into a power-frequency relation, a brain wave curve is synchronously displayed on a screen in real time, and brain wave absolute power values of delta, theta, alpha and beta in each brain area position of four frequency domains are marked on a skull model chart.

Each volunteer was first controlled by recording 3 minutes of brain electrical activity as a blank without sniffing any essential oils or other significant odors. Then, sniffing for 3min without adding blank solid fragrance of essential oil and recording EEG signals. The third sniffing treatment was performed by giving solid sniffing to volunteers 90470 or 90472 for 3min and recording brain electrical signals. Each sniffing is carried out in a closed room with the same space size, the interval of each sniffing is 10min, and each volunteer carries out the second same test at the same time after one week. The brain wave data is collected to avoid the interference of various external factors such as the order of the orders, and all volunteers are required to keep a relaxed state, and the bodies are not easy to blink and shake. These representative signals are then superimposed. The analysis result is that the percentage of delta, theta, alpha and beta 4 frequency domains in the total power of 1-30Hz is calculated, and the results of the two tests are averaged.

Second, experimental results

1. Aroma concentration survey

(1) 9047066 people

A B C D F G I J K

1 50 4 10 2

2 42 4 17 3

3 5 27 18 14

4 5 36 21 3

5 31 5 40 10 1 10 1 3

6 23 42

7 6 32 20 11

The 2% preference ratio is: 8 percent of

The preference ratio of 4% is: 41 percent

The preference ratio of 6% is: 28 percent of

(2) 9047176 people

A B C D F G I J K

1 65 2 7 2

2 51 4 16 5

3 7 37 20 12

4 6 41 24 5

5 42 9 56 16 3 14 4 5

6 28 48

7 8 38 25 5

The 2% preference ratio is: 10 percent of

The preference ratio of 4% is: 49 percent of

The preference ratio of 6% is: 27 percent of

(3) 9047272 people

A B C D F G I J K

1 55 4 8 5

2 45 3 20 4

3 5 30 20 17

4 2 38 29 3

5 37 8 43 18 6 8 3 3

6 30 42

7 9 30 23 10

The 2% preference ratio is: 7 percent of

The preference ratio of 4% is: 42 percent of

The preference ratio of 6% is: 28 percent of

(4) 9047379 people

A B C D F G I J K

1 63 4 7 5

2 50 7 16 6

3 9 34 17 19

4 9 40 19 11

5 54 10 17 12 15 2 1 9

6 24 55

7 6 42 8 23

The 2% preference ratio is: 12 percent of

The preference ratio of 4% is: 43 percent

The preference ratio of 6% is: 22 percent

The results show that: a concentration of 4% is the most suitable concentration of incense.

2. Olfaction preference survey of different kinds of anti-depression fragrance

The purpose of the test is as follows: the olfactory preference of the odorant for the four numbered antidepressant fragrances (90470, 90471, 90472, 90473) was investigated, i.e. whether the test person liked or disliked a fragrance of a certain number.

The test method comprises the following steps: the testee smells the incense in a closed room for 30 min. And finally, finishing the aroma evaluation table. Including preference, feeling after smelling fragrance, etc. Each numbered incense corresponds to about 90 persons, and the total number of persons to be investigated is 348 persons.

And (3) test results:

detailed data:

and (4) counting results:

the results of the test showed 90470 to be the most favoured, next to 90472 and 90473 and finally 90471. The feeling of calmness, comfort and warmth is the most common after smelling the fragrance. Meanwhile, because the unfavorable rate of 90472 is far lower than that of 90473, two formulas are finally selected for the next experiment.

3. Evaluation of efficacy of different species of antidepressive incense

1) Animal model test:

the purpose of the test is as follows: animal experiments are carried out to investigate the efficacy of different species of the anti-depression fragrance.

The test method comprises the following steps: the experimental animals are Kunming mice and 60 male animals. The tail suspension experiment and forced swimming experiment are carried out. After suspending the tail or putting into water, the mice give up struggling, and show disappointed state in a discontinuous immobile or floating state.

The basic idea of the test is as follows: grouping and administration: randomly dividing the mice into 6 groups, each group comprises 10 mice, and the mice are respectively 2 blank control groups; 2 non-perfuming coil smelling groups; 2 preferably perfumed coil sniffing groups. Feeding for 3d, and performing the experiment after smelling for 15min on 4 d.

Smelling the fragrance: igniting the incense coil outdoors until the burning is stable, putting the incense coil into an animal incense smelling cage, stably expanding the incense for 15min, and putting the animal incense for 15 min. Animals were free to feed and drink during the experiment.

Time for which mice remained immobile in both depression models

After smelling 90470 and 90472, the mice had shorter immobility time in both tail suspension experiment and forced swimming experiment. In the tail suspension experiment, compared with the blank fragrance, both fragrances are greatly reduced (P is less than 0.01) compared with the blank fragrance. In forced swimming experiments, the time for the mice to remain immobile after smelling the two smells also significantly decreased, but did not reach a significant level.

2) Effect of different kinds of antidepressive incense on human brain waves

There are multiple sites in the brain that participate in the process of producing emotions. Scientists have demonstrated that there are indeed sensation-related systems in the brain and that they end up as limbic systems.

The Papez theory of loops holds that: the peripheral lobe, including the hippocampus, cingulate gyrus, papillary body and hypothalamus, constitutes a loop that is associated with the emotional sensory experience. The circuit formed by hippocampus, fornix, papillary body, papillary thalamic fascicle, cingulate gyrus, frontal lobe of cerebral cortex and hippocampus is used as the emotional thought pathway. The frontal, parietal, occipital and temporal 4 lobes all partially extend to the medial aspect of the cerebral hemisphere. Above the diencephalon there is a corpus callosum connecting the left and right hemispheres. The groove above the corpus callosum is called the corpus callosum groove, which bypasses behind the corpus callosum and moves forward to the hippocampal groove. The cingulum is arranged above the callosum groove, and the cingulum is arranged between the other callosum grooves.

The electroencephalogram experiment records electroencephalograms before and after the human smells the antidepressant aroma, and analyzes the change of the electroencephalogram. Namely, the mental state change of the person is analyzed according to the brain wave change condition of each frequency domain range, and the efficacy of the incense is evaluated.

The number of tested persons: the first formula is 25 persons, and the second formula is 22 persons. Volunteers smell fragrance twice, and data were averaged over the two tests.

1. The experimental results are as follows:

2. and (3) analyzing an experimental result:

the first formula and the second formula have antidepressant effects, and are characterized in that the power percentages of low-frequency waves delta and theta in the electroencephalogram waves are obviously reduced after smelling fragrance, the alpha waves are obviously increased, and the high-frequency waves beta waves are also reduced.

Comparing the two formulas, wherein the rising of alpha wave of the formula I is more reflected as alpha 1, namely low-frequency alpha wave; the beta wave reduction is significant. And the rising of alpha 2 in the rising of the formula two alpha waves is more remarkable than that of alpha 1, namely, the rising of high-frequency alpha waves is dominant. The beta wave is not reduced or is not obvious before and after smelling the fragrance, and particularly the beta wave is not changed after the fragrance is smelled by the beta wave 1.

This shows that both formula one and formula two have good antidepressant effect, and formula one and formula two have different emphasis on the use of antidepressant effect.

The formula I has the advantages that the low-frequency alpha wave is increased predominantly, and the beta wave is reduced remarkably, so that the formula can better relieve the tension mood and the anxiety feeling of depressed people when relieving the depression symptoms of the depressed people.

The elevation of high-frequency alpha waves is dominant in the formula II, and beta waves have no obvious change, so that the depressed mood of people with obvious depressed mood and depressed mood is relieved after smelling fragrance, and meanwhile, the people do not feel too much sinking.

Formula one and formula two have different emphasis on the use of antidepressant efficacy.

The present invention has been described in detail, and it should be understood that the detailed description and specific examples, while indicating the preferred embodiment of the invention, are intended for purposes of illustration only and are not intended to limit the scope of the invention.

Claims

1. An anti-depression incense which is characterized in that: the formula of the raw materials comprises, by weight, 55-65% of camphorwood powder, 5-10% of 90470 antidepressant essential oil, 28-36% of wood sticking powder and 1-2% of potassium nitrate; wherein the 90470 formula of the antidepressant essential oil comprises, by weight, 18-22% of lavender oil, 27-33% of citronella oil, 18-22% of pure cinnamomum camphora leaf oil, 9-11% of litsea cubeba oil and 18-22% of benzoin paste.

2. The antidepressant according to claim 1, characterized in that: the camphor wood powder is 100-mesh camphor leaf wood powder.

3. The preparation method of the depression-inhibiting incense is characterized by comprising the following steps: the method comprises the following steps of (1),

4) and forming, namely pressing and forming the slurry, and drying to obtain the depression-inhibiting fragrance.

4. The method for preparing the antidepressant incense according to claim 3, which is characterized in that: in the step 3), the adding amount of water is 8-12 times of the weight of 90470 antidepressant essential oil, and the stirring time is 20-40 minutes.

5. The method for preparing the antidepressant incense according to claim 3, which is characterized in that: in the forming procedure of the step 4), firstly, priming is carried out on bamboo sticks when making stick incense, firstly, wood sticking powder for priming is put into an incense making machine, the bamboo sticks are selected and watered, then the stick incense is put into the incense making machine, the incense making machine is started, the machine is stopped after 60-90 seconds, and padding blanks after priming are taken out; then the operation of applying the inner powder and the upper skin powder is carried out.