CN115581653B - Shumin repair agent and application thereof - Google Patents
Shumin repair agent and application thereof Download PDFInfo
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- CN115581653B CN115581653B CN202211211042.0A CN202211211042A CN115581653B CN 115581653 B CN115581653 B CN 115581653B CN 202211211042 A CN202211211042 A CN 202211211042A CN 115581653 B CN115581653 B CN 115581653B
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- A—HUMAN NECESSITIES
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- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
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- A61K8/00—Cosmetics or similar toiletry preparations
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- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9755—Gymnosperms [Coniferophyta]
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Abstract
The invention relates to the field of skin care product additives, and particularly discloses a allergy-relieving prosthetic element and application thereof. A sulpirin comprising the following components: dendrobium officinale extract, aesculus hippocastanum extract, taxus cuspidata leaf extract, radix Stephaniae Tetrandrae extract, rhizoma smilacis glabrae root extract, glycyrrhiza glabra extract and water; the preparation method of the European horse chestnut extract comprises the following steps: step 1), preparing European horse chestnut seed powder; step 2), putting the European horse chestnut seed powder into water, then putting the alternaria alternata, the trichoderma koningii and the trichoderma reesei, uniformly mixing and soaking; step 3), filtering the soaked European horse chestnut seed powder to obtain filter residues and primary filtrate; step 4), filter-pressing filter residues to obtain secondary filtrate, and mixing the secondary filtrate with the primary filtrate to obtain mixed filtrate; and 5) concentrating the mixed filtrate under reduced pressure, and drying to obtain the European horse chestnut extract. The invention has the advantage of rapid treatment of hormonal faces.
Description
Technical Field
The invention relates to the field of skin care product additives, in particular to a allergy-relieving repair agent and application thereof.
Background
Hormonal faces are one type of medicinal acne, also known as hormonal acne, mainly due to the use of hormonal containing drugs or cosmetics.
The hormone face is divided into four main stages, wherein the first stage is mainly acne, a small amount of papuloacnes and pustular acnes are mainly acne, the total skin damage is smaller than 30, the second stage is acne and a medium amount of papuloacnes and pustular acnes, the total skin damage is 31-50, the third stage is mainly papuloacnes and pustular acnes, the total skin damage is 50-100, the number of nodular acnes is smaller than 3, the fourth stage is nodular acnes, cystic acnes and acne conglobata, the total skin damage is larger than 100, and the nodular acnes and the cystic acnes are larger than 3.
The hormone face can seriously affect the psychological health of the patient, and the hormone face is very difficult to treat, and generally needs long-time conditioning, so that the patient is greatly puzzled, and a product for rapidly treating the hormone face is urgently needed.
Disclosure of Invention
In order to rapidly treat the hormonal face, the application provides a sulensitive prosthetic and application thereof.
In a first aspect, the present application provides a sulbactam, which adopts the following technical scheme:
a sulensin prosthetic, characterized in that: comprises the following components in percentage by mass:
1.5% -2.5% of dendrobium candidum extract;
1.5% -2.5% of European horse chestnut extract;
1.5% -2.5% of taxus cuspidata leaf extract;
1.5% -2.5% of tetrandra root extract;
1.5% -2.5% of glabrous greenbrier rhizome extract;
1.5% -2.5% of licorice extract;
the balance of water;
the preparation method of the European horse chestnut extract comprises the following steps:
step 1), taking seeds of the European horse chestnut, sun-curing and crushing to obtain seed powder of the European horse chestnut;
step 2), putting the European horse chestnut seed powder into water, then putting the alternaria alternata, the trichoderma koningii and the trichoderma reesei into the water, uniformly mixing, soaking for 48-50 hours at 60-70 ℃, heating to 95-98 ℃, and keeping for 3-4 minutes;
step 3), filtering the soaked European horse chestnut seed powder to obtain filter residues and primary filtrate;
step 4), filter-pressing filter residues to obtain secondary filtrate, and mixing the secondary filtrate with the primary filtrate to obtain mixed filtrate;
step 5), concentrating the mixed filtrate into paste under reduced pressure, and drying the paste to obtain powder, namely the Aesculus hippocastanum extract.
By adopting the technical scheme, the dendrobium candidum extract, the European horse chestnut extract, the taxus cuspidata leaf extract, the stephania tetrandra extract, the glabrous greenbrier rhizome extract and the glabrous greenbrier rhizome extract are compounded, so that the allergy-relieving prosthetic has the effect of better conditioning the skin, the allergy-relieving effect is achieved, the allergy-relieving prosthetic can be sedated and antipruritic after being used for about 5 minutes, and the comfort level of the skin injury of a patient is improved.
The extraction effect of the saporin, flavonoid and tannin in the European horse chestnut extract is better by adopting a specific process to extract the European horse chestnut extract, the effect of promoting the release of histamine is better after the extract is matched with the active ingredients of other components, the skin can be quickly antiallergic, the blood is not easy to enter into the cell tissues and is not easy to swell by improving the blood vessel, so that hormonal acne is not easy to relapse, and the repeated effect is not easy to occur in the continuous use process, so that the effect of treating the hormonal face is better.
The method has the advantages that the enzymolysis is carried out by adopting the combination of the alternaria alternate, the trichoderma koningii and the trichoderma reesei, so that the cell wall/membrane of the aesculus hippocastanum seed is thoroughly destroyed, the effective components in the cells are effectively released, the active components are not easy to remain in the cells, the water-soluble active components and the sediment and impurities are thoroughly separated, the water-soluble active components are dissolved in the water, more active components are obtained after the sediment is filtered, the extraction efficiency is higher, the concentration of the obtained active components is higher, the content of various active components is higher, the extraction effect of the saporin, flavonoid and tannin is better, the effect of improving the quality hormone face is realized, the treatment effect is faster, and the relapse is not easy to occur.
Preferably, the total mass of the trichoderma reesei, trichoderma koningii and trichoderma reesei added in the step 2) is 0.02% of the mass of the hippocastanum seed powder added.
By adopting the technical scheme, the effect of separating the cell wall/membrane is better and the cost can be effectively controlled by specifically selecting the ratio of the total mass of the alternaria alternate, the trichoderma koningii and the trichoderma reesei to the mass of the aesculus hippocampus seed powder.
Preferably, the mass ratio of the alternaria alternate, the trichoderma koningii and the trichoderma reesei in the step 2) is 1:1-2:1-2.
By adopting the technical scheme, the mass ratio of the alternaria, the trichoderma koningii and the trichoderma reesei is specifically selected, so that the interaction symbiotic effect of the alternaria, the trichoderma koningii and the trichoderma reesei is better, the better and faster decomposition effect is achieved, and the extraction effect is better.
Preferably, in the step 4), the pressure is 10 to 12MPa during the press filtration.
Through adopting above-mentioned technical scheme, through selecting specific pressure for can further destroy cell wall/membrane through pressure and extrude the effective ingredient of residue through pressure and draw into the filtrate when the filter-pressing, further improve the effect of extraction, make the effect of treating hormone face better after the extract that obtains is compound with other effective ingredients.
Preferably, the preparation method of the dendrobium candidum extract comprises the following steps:
step 01), taking the rhizome of dendrobium candidum, sun-curing and crushing to obtain dendrobium candidum powder;
step 02), putting dendrobium candidum powder into water, then adding aspergillus niger, trichoderma viride and haelia fiber bacteria, uniformly stirring, and soaking for 48-50 hours at 36-38 ℃; heating to 95-98 ℃, and keeping for 3-4 min;
step 03), filtering out the soaked dendrobium candidum powder to obtain primary filter residues and primary filtrate;
step 04), putting the primary filter residue into an ethanol solution with the concentration of 75-80%, soaking for 24-26 hours at the temperature of 80-85 ℃, and filtering to obtain secondary filtrate and secondary filter residue;
step 05), filter-pressing the secondary filter residue to obtain a tertiary filtrate;
step 06), mixing the tertiary filtrate, the secondary filtrate and the primary filtrate to obtain mixed filtrate;
step 07), reducing the pressure of the mixed filtrate, concentrating the mixed filtrate into paste, and drying the paste to obtain powder, namely the dendrobium candidum extract.
Through adopting above-mentioned technical scheme, through adopting special technology to draw Dendrobium officinale for extract effect is better, especially to the extraction effect of active polysaccharide in the Dendrobium officinale, colloid is better, make active polysaccharide, colloid and other extract's active ingredient mutually support the back, the treatment to hormone face is better, it is faster and be difficult for relapse to take effect, and antioxidation, get rid of the effect of free radical better moreover, make skin damage department be difficult for attacking, protect skin damage position better, thereby repair skin damage department better, with the effect of improvement quality.
Because the main components extracted from the dendrobium officinale are colloid and active polysaccharide, the aspergillus niger, trichoderma viride and Ha's fibrous bacteria are selected to be compounded, the effect of promoting symbiosis is achieved, the enzymolysis effect is better, meanwhile, the cell wall/membrane of the dendrobium officinale can be subjected to enzymolysis in a targeted manner, the decomposition consumption of the active polysaccharide is reduced, the active polysaccharide and colloid in the dendrobium officinale can be better extracted, the content of the active polysaccharide and colloid in the dendrobium officinale extract is higher, and the effect of treating hormone faces is better and the effect is quicker by being better matched with the active components of other extracts.
The method has the advantages that the ethanol solution with the ethanol concentration of 75-80% is adopted for extraction, after the cell wall/membrane is damaged, the extraction effect is better, the content of active polysaccharide and colloid in the extract is further improved, and the quality hormone face effect of the prepared product is better.
Preferably, the total mass of the aspergillus niger, the trichoderma viride and the haemagglutinin is 0.02% of the mass of the dendrobium candidum powder in the step 02).
By adopting the technical scheme, the ratio of the total mass of aspergillus niger, trichoderma viride and haeliophaga is specifically selected to the mass of dendrobium candidum powder, so that the effect of separating cell walls/membranes is better, the waste of strains is reduced, and the method has better economic value.
Preferably, in the step 02), the mass ratio of aspergillus niger to trichoderma viride to phagostimulant is 1-2:1-1.5:1-1.5.
By adopting the technical scheme, the proportion of aspergillus niger, trichoderma viride and haelie fibrous bacteria is specifically selected, so that the method has better symbiotic effect, and the efficiency of decomposing cell walls/membranes is higher, so that the extraction effect is better, and the effect of the prepared sulensitive prosthetic element is better.
Preferably, in the step 05), the pressure is 5 to 6MPa during the press filtration.
Through adopting above-mentioned technical scheme, through the pressure of specific selection filter-pressing for the residual material in the cell is better by further extrusion, makes extraction effect better.
In a second aspect, the present application provides an application of a sulbactam, which adopts the following technical scheme:
the application of the sulbactam is characterized in that the sulbactam is applied to skin care products.
Preferably, the allergy-relieving restoration can be added into essence, skin lotion, skin cream and facial mask.
By adopting the technical scheme, the skin care product has the effect of rapidly treating the hormone face and has a good repairing effect on the skin.
Preferably, the addition amount of the sulbactam in the skin care product is 0.1-5%.
Preferably, the addition amount of the sulbactam in the skin care product can be 0.1%, 0.5%, 1%, 2%, 3%, 4% and 5%.
By adopting the technical scheme, the additive amount is selected in the same way, so that the skin repairing effect is better, the hormone face can be rapidly treated, the cost is controlled, and the economic value is higher.
In summary, the present application has the following beneficial effects:
1. according to the method, the enzymolysis is carried out by compounding the alternaria alternata, the trichoderma koningii and the trichoderma reesei, so that the cell wall/membrane of the European horse chestnut seeds is thoroughly destroyed, the effective components in the cells are effectively released, the effective components are not easy to remain in the cells, the water-soluble effective components are separated from the sediment and the impurities thoroughly, the water-soluble effective components are dissolved in the water, more active components are obtained after the sediment is filtered, the extraction efficiency is higher, the concentration of the obtained active components is higher, the content of various active components is higher, the extraction effects of saporin, tannin are better, the effect of improving the quality hormone face is realized, the curative effect is faster, and the relapse is not easy to occur.
2. In the application, aspergillus niger, trichoderma viride and Ha's fibrous phage are preferably selected for compounding, so that the symbiotic effect is improved, the enzymolysis effect is better, meanwhile, the cell wall/membrane of the dendrobium candidum is subjected to enzymolysis in a targeted manner, the decomposition consumption of active polysaccharide is reduced, the active polysaccharide and colloid in the dendrobium candidum can be better extracted, the content of the active polysaccharide and colloid in the dendrobium candidum extract is higher, and the active components of other extracts are better matched, so that the effect of treating the hormone face is better and the effect is quicker.
3. In the application, the ethanol solution with the ethanol concentration of 75-80% is preferably adopted for extraction, so that the extraction effect is better after the cell wall/membrane is damaged, the content of active polysaccharide and colloid in the extract is further improved, and the effect of the prepared product quality hormone face is better.
Detailed Description
The present application is described in further detail below with reference to examples.
Example 1
A sulensin prosthetic comprises the following components:
dendrobium officinale extract, aesculus hippocastanum extract, taxus cuspidata leaf extract, radix Stephaniae Tetrandrae extract, rhizoma Smilacis Glabrae root extract, glycyrrhiza glabra extract and water.
The preparation method of the sulpirin comprises the following steps:
putting 1.5kg of dendrobium candidum extract, 1.5kg of European horse chestnut extract, 1.5kg of taxus cuspidata leaf extract, 1.5kg of radix stephaniae tetrandrae extract, 1.5kg of rhizoma smilacis glabrae root extract, 1.5kg of liquorice root extract and 91kg of water into a stirring kettle, stirring at the rotating speed of 60r/min for 15min, discharging and packaging to obtain the allergy-relieving prosthetic.
Wherein, the dendrobium candidum extract is an extract prepared by a water extraction method, and the proportion of the extract is 10:1, purchased from kepler biotechnology limited of shanxi.
The taxus cuspidata leaf extract is an extract prepared by a water extraction method, and the proportion of the extract is 10:1, available from western security australian technologies.
The tetrandra root extract is an extract prepared by a water extraction method, and the proportion of the extract is 10:1, purchased from Shanyang Union Peak Biotechnology Limited liability company.
The glabrous greenbrier rhizome extract is prepared by a water extraction method, and the proportion of the extract is 10:1 purchased from Ningxia vanilla biotechnology Co.
The licorice root extract is prepared by a water extraction method, and the proportion of the extract 10 is as follows: 1, purchased from the company of the biological engineering, inc. of Sianzueli.
The preparation method of the European horse chestnut extract comprises the following steps:
step 1), taking seeds of the European horse chestnut, sun-curing, crushing, and sieving with a 200-mesh sieve to obtain seed powder of the European horse chestnut;
step 2), adding 20kg of European horse chestnut seed powder into 60kg of water, then adding 1g of alternaria alternata, 2g of trichoderma koningii and 1g of trichoderma reesei, uniformly mixing, soaking for 50 hours at 60 ℃, heating to 95 ℃, and keeping for 4 minutes;
step 3), filtering the soaked European horse chestnut seed powder by using an 800-mesh screen to obtain filter residues and primary filtrate;
step 4), filter-pressing filter residues by a filter press, wherein the filter-pressing pressure is 10MPa, so as to obtain secondary filtrate, and mixing the secondary filtrate with the primary filtrate to obtain mixed filtrate;
step 5), reducing the pressure of the mixed filtrate to 0.01MPa, heating, evaporating and concentrating to paste, and spray-drying the paste to obtain powder, namely the Aesculus hippocastanum extract, wherein the proportion of the extract is 10:1.
among them, alternaria alternata is purchased from Beijing Bai Ou Bo Wei Biotechnology Co., ltd., no. Bio-24515.
Among them, trichoderma koningii was purchased from Beijing Bai Ou Bo Wei Biotechnology Co., ltd., no. Bio-28861.
Among them, trichoderma reesei was purchased from Beijing Bai Ou Bo Wei Biotechnology Co., ltd., accession No. Bio-81658.
Example 2
Compared with example 1, the sulpirin only differs from the sulpirin:
the preparation method of the sulpirin comprises the following steps:
putting herba Dendrobii extract 2kg, aesculus hippocastanum extract 2kg, taxus cuspidata leaf extract 2kg, radix Stephaniae Tetrandrae extract 2kg, rhizoma Smilacis Glabrae root extract 2kg, glycyrrhiza glabra extract 2kg and water 88kg into stirring kettle, stirring at rotation speed of 60r/min for 15min, discharging, and packaging to obtain sulindac.
Example 3
Compared with example 1, the sulpirin only differs from the sulpirin:
the preparation method of the sulpirin comprises the following steps:
putting 2.5kg of dendrobium candidum extract, 2.5kg of European horse chestnut extract, 2.5kg of taxus cuspidata leaf extract, 2.5kg of radix stephaniae tetrandrae extract, 2.5kg of rhizoma smilacis glabrae root extract, 2.5kg of liquorice root extract and 85kg of water into a stirring kettle, stirring at the rotating speed of 60r/min for 15min, discharging and packaging to obtain the allergy-relieving prosthetic.
Example 4
Compared with example 1, the sulpirin only differs from the sulpirin:
the preparation method of the European horse chestnut extract comprises the following steps:
step 1), taking seeds of the European horse chestnut, sun-curing, crushing, and sieving with a 300-mesh sieve to obtain seed powder of the European horse chestnut;
step 2), putting 20kg of European horse chestnut seed powder into 80kg of water, then putting 1g of alternaria alternata, 2g of trichoderma koningii and 1g of trichoderma reesei, uniformly mixing, soaking at 70 ℃ for 48 hours, heating to 98 ℃, and keeping for 3 minutes;
step 3), filtering the soaked European horse chestnut seed powder by using an 800-mesh screen to obtain filter residues and primary filtrate;
step 4), filter-pressing filter residues by a filter press, wherein the filter-pressing pressure is 12MPa, so as to obtain secondary filtrate, and mixing the secondary filtrate with the primary filtrate to obtain mixed filtrate;
step 5), reducing the pressure of the mixed filtrate to 0.01MPa, heating, evaporating and concentrating to paste, and spray-drying the paste to obtain powder, namely the Aesculus hippocastanum extract, wherein the proportion of the extract is 10:1.
example 5
Compared with example 1, the sulpirin only differs from the sulpirin:
the preparation method of the European horse chestnut extract comprises the following steps:
step 2), adding 20kg of European horse chestnut seed powder into 60kg of water, adding 1g of alternaria alternata, 1g of trichoderma koningii and 2g of trichoderma reesei, uniformly mixing, soaking at 60 ℃ for 50 hours, heating to 95 ℃ and keeping for 4 minutes.
Example 6
Compared with example 1, the sulpirin only differs from the sulpirin:
the preparation method of the European horse chestnut extract comprises the following steps:
step 2), adding 20kg of European horse chestnut seed powder into 60kg of water, adding 1g of alternaria alternata, 1.5g of trichoderma koningii and 1.5g of trichoderma reesei, uniformly mixing, soaking for 50h at 60 ℃, heating to 95 ℃, and keeping for 4min.
Example 7
Compared with example 1, the sulpirin only differs from the sulpirin:
the home-made dendrobium candidum extract is adopted to replace the commercially available dendrobium candidum extract in an equivalent way.
The preparation method of the dendrobium candidum extract comprises the following steps:
step 01), taking the rhizome of dendrobium candidum, sun-curing, crushing, and sieving with a 200-mesh sieve to obtain dendrobium candidum powder;
step 02), adding 20kg of dendrobium candidum powder into 60kg of water, then adding 2kg of aspergillus niger, 1kg of trichoderma viride and 1kg of Haw phaga fiber, uniformly stirring, and soaking for 50 hours at 36 ℃; heating to 95deg.C, and maintaining for 4min;
step 03), filtering out the soaked dendrobium candidum powder through a 800-mesh screen to obtain primary filter residues and primary filtrate;
step 04), putting the primary filter residue into 40kg of ethanol solution with the concentration of 75%, soaking for 26 hours at 80 ℃, and filtering to obtain secondary filtrate and secondary filter residue;
step 05), press-filtering the secondary filter residues through a press filter, wherein the pressure is 5MPa, and obtaining tertiary filtrate;
step 06), mixing the tertiary filtrate, the secondary filtrate and the primary filtrate to obtain mixed filtrate;
step 07), reducing the pressure of the mixed filtrate, concentrating the mixed filtrate into paste, and spray-drying the paste to obtain powder, namely the dendrobium candidum extract, wherein the ratio of the extract is 10:1.
wherein Aspergillus niger is purchased from Jinan Rong Zheng chemical industry Co.
Wherein Trichoderma viride is purchased from Shandong Nodek Biotechnology Co., ltd
Among them, hashimoto is purchased from Beijing Bai Bo Wei Biotechnology Co., ltd., and is numbered Bio-75196.
Example 8
Compared with example 7, the sulpirin only differs from the sulpirin:
the home-made dendrobium candidum extract is adopted to replace the commercially available dendrobium candidum extract in an equivalent way.
The preparation method of the dendrobium candidum extract comprises the following steps:
step 01), taking the rhizome of dendrobium candidum, sun-curing, crushing, and sieving with a 200-mesh sieve to obtain dendrobium candidum powder;
step 02), adding 20kg of dendrobium candidum powder into 80kg of water, then adding 2kg of aspergillus niger, 1kg of trichoderma viride and 1kg of Haw phaga fiber, uniformly stirring, and soaking for 48 hours at 38 ℃; heating to 98deg.C, and maintaining for 3min;
step 03), filtering out the soaked dendrobium candidum powder through a 800-mesh screen to obtain primary filter residues and primary filtrate;
step 04), putting the primary filter residue into 60kg of 80% ethanol solution, soaking for 24 hours at 85 ℃, and filtering to obtain secondary filtrate and secondary filter residue;
step 05), press-filtering the secondary filter residues through a press filter, wherein the pressure is 6MPa, and obtaining tertiary filtrate;
step 06), mixing the tertiary filtrate, the secondary filtrate and the primary filtrate to obtain mixed filtrate;
step 07), reducing the pressure of the mixed filtrate, concentrating the mixed filtrate into paste, and spray-drying the paste to obtain powder, namely the dendrobium candidum extract, wherein the ratio of the extract is 10:1.
example 9
Compared with example 7, the sulpirin only differs from the sulpirin:
the preparation method of the dendrobium candidum extract comprises the following steps:
step 02), adding 20kg of dendrobium candidum powder into 60kg of water, then adding 1.5kg of aspergillus niger, 1.2kg of trichoderma viride and 1.3kg of Haw phaga, uniformly stirring, and soaking for 50 hours at 36 ℃; heating to 95deg.C, and maintaining for 4min;
example 10
Compared with example 7, the sulpirin only differs from the sulpirin:
the preparation method of the dendrobium candidum extract comprises the following steps:
step 02), adding 20kg of dendrobium candidum powder into 60kg of water, then adding 1kg of aspergillus niger, 1.5kg of trichoderma viride and 1.5kg of Haw phaga, uniformly stirring, and soaking for 50 hours at 36 ℃; heating to 95deg.C, and maintaining for 4min;
example 11
Compared with example 7, the sulpirin only differs from the sulpirin:
and (3) replacing Aspergillus niger with the same amount of alternaria alternata.
Example 12
Compared with example 7, the sulpirin only differs from the sulpirin:
and replacing the trichoderma viride with the same amount of alternaria alternata.
Example 13
Compared with example 7, the sulpirin only differs from the sulpirin:
equal amounts of alternaria alternata were used to replace the hawk-type fibroblasts.
Comparative example 1
Compared with example 1, the sulpirin only differs from the sulpirin:
aspergillus niger is used for replacing alternaria alternata in equal quantity.
Wherein Aspergillus niger is purchased from Jinan Rong Zheng chemical industry Co.
Comparative example 2
Compared with example 1, the sulpirin only differs from the sulpirin:
the same amount of Aspergillus niger was used instead of Trichoderma koningii.
Wherein Aspergillus niger is purchased from Jinan Rong Zheng chemical industry Co.
Comparative example 3
Compared with example 1, the sulpirin only differs from the sulpirin:
aspergillus niger was used in an equivalent replacement of Trichoderma reesei.
Wherein Aspergillus niger is purchased from Jinan Rong Zheng chemical industry Co.
Comparative example 4
Compared with example 1, the sulpirin only differs from the sulpirin:
the commercial European horse chestnut extract is used for replacing the homemade European horse chestnut extract in an equivalent way. The European horse chestnut extract is prepared by a water extraction method, and the proportion of the extract is 10:1.
experiment 1
Several volunteers were summoned, aged 25-35 years, all women, all hormonal face patients, and in severe stages, total skin lesions were greater than 100.
The sulbactam prepared in each example and the comparative example is used by volunteers in groups, the sulbactam is used once a day in the morning and evening, the facial cleanser without anti-inflammatory efficacy is firstly used for cleaning the face before use, after the water is wiped off, the sulbactam is diluted by distilled water until the sulbactam content is 2%, the repair liquid is prepared, 5ml of the repair liquid is taken and is uniformly smeared on the face, and the affected part is ensured to be covered by the repair liquid.
Total skin loss before use was recorded and total skin loss at 2d, 3d, 5d, 7d was recorded. The average was calculated for every 10 persons in one group.
The experimental data of experiment 1 are detailed in table 1.
TABLE 1
According to the data in table 1, the comparison of the data in the embodiment 1 and the data in the comparative examples 1 to 4 shows that when the aesculus hippocastanum extract is extracted by adopting a special extraction method, the sulindac has the effect of treating the hormone face more quickly and more obviously, and when the aspergillus niger is adopted to replace any one of the alternaria alternate, the trichoderma koningii and the trichoderma reesei, the efficiency of treating the hormone face is obviously reduced, and the compound of the alternaria alternate, the trichoderma koningii and the trichoderma reesei in a specific proportion can have more thorough decomposition effect on the cell wall/membrane of the aesculus hippocastanum, so that the effective substances in the extracted aesculus hippocastanum extract and the effective substances in the common water extraction have certain differences in composition and content, thereby the effect of treating the hormone face by the sulindac quality is greatly different, the treatment effect of the hormone face is effectively accelerated, and the recrudescence is not easy to occur.
As can be seen from the comparison of the data of example 1 and example 7 in table 1, the effect of the sulindac on treating hormonal faces is more rapid when the dendrobium officinale extract is extracted by a specific extraction method.
According to the comparison of the data of the embodiment 7 and the embodiment 11-13 in the table 1, when the alternaria alternata is used for replacing any one of aspergillus niger, trichoderma viride and phagostimula haliotidis, the effect of accelerating the treatment of the hormone face is reduced, and the fact that when the aspergillus niger, the trichoderma viride and the phagostimula haliotidis are compounded, the cell wall/membrane of the dendrobium candidum is decomposed thoroughly is proved, so that the content and the composition of the effective components in the extracted dendrobium candidum extract are different from those of the common water extraction method to a certain extent, and the effect of accelerating the treatment of the hormone face can be further improved by matching with the effective components of other components.
The present embodiment is merely illustrative of the present application and is not intended to be limiting, and those skilled in the art, after having read the present specification, may make modifications to the present embodiment without creative contribution as required, but is protected by patent laws within the scope of the claims of the present application.
Claims (9)
1. A sulensin prosthetic, characterized in that: comprises the following components in percentage by mass:
1.5% -2.5% of dendrobium candidum extract;
1.5% -2.5% of European horse chestnut extract;
1.5% -2.5% of taxus cuspidata leaf extract;
1.5% -2.5% of tetrandra root extract;
1.5% -2.5% of glabrous greenbrier rhizome extract;
1.5% -2.5% of licorice extract;
the balance of water;
the preparation method of the European horse chestnut extract comprises the following steps:
step 1), taking seeds of the European horse chestnut, sun-curing and crushing to obtain seed powder of the European horse chestnut;
step 2), putting the European horse chestnut seed powder into water, then putting the alternaria alternata, the trichoderma koningii and the trichoderma reesei into the water, uniformly mixing, soaking for 48-50 hours at 60-70 ℃, heating to 95-98 ℃, and keeping for 3-4 minutes;
step 3), filtering the soaked European horse chestnut seed powder to obtain filter residues and primary filtrate;
step 4), filter-pressing filter residues to obtain secondary filtrate, and mixing the secondary filtrate with the primary filtrate to obtain mixed filtrate;
step 5), concentrating the mixed filtrate into paste under reduced pressure, and drying the paste to obtain powder, namely the Aesculus hippocastanum extract;
the preparation method of the dendrobium candidum extract comprises the following steps:
step 01), taking the rhizome of dendrobium candidum, sun-curing and crushing to obtain dendrobium candidum powder;
step 02), putting dendrobium candidum powder into water, then adding aspergillus niger, trichoderma viride and haelia fiber bacteria, uniformly stirring, and soaking for 48-50 hours at 36-38 ℃; heating to 95-98 ℃, and keeping for 3-4 min;
step 03), filtering out the soaked dendrobium candidum powder to obtain primary filter residues and primary filtrate;
step 04), putting the primary filter residue into an ethanol solution with the concentration of 75-80%, soaking for 24-26 hours at the temperature of 80-85 ℃, and filtering to obtain secondary filtrate and secondary filter residue;
step 05), filter-pressing the secondary filter residue to obtain a tertiary filtrate;
step 06), mixing the tertiary filtrate, the secondary filtrate and the primary filtrate to obtain mixed filtrate;
step 07), reducing the pressure of the mixed filtrate, concentrating the mixed filtrate into paste, and drying the paste to obtain powder, namely the dendrobium candidum extract.
2. A sulbactam according to claim 1, wherein: the total mass of the input of the alternaria alternata, the trichoderma koningii and the trichoderma reesei in the step 2) is 0.02 percent of the mass of the input of the European horse chestnut seed powder.
3. A sulbactam according to claim 2, wherein: the mass ratio of the alternaria alternate to the Trichoderma koningii to the Trichoderma reesei in the step 2) is 1:1-2:1-2.
4. A sulbactam according to claim 1, wherein: in the step 4), the pressure is 10-12 MPa during filter pressing.
5. A sulbactam according to any one of claims 1 to 4, wherein: the total mass of the aspergillus niger, the trichoderma viride and the haemagglutinin is 0.02 percent of the mass of the dendrobium candidum powder in the step 02).
6. A sulbactam according to claim 5, wherein: in the step 02), the mass ratio of the aspergillus niger to the trichoderma viride to the haemangionella is 1-2:1-1.5:1-1.5.
7. A sulbactam according to any one of claims 1 to 4, wherein: in the step 05), the pressure is 5-6 MPa during filter pressing.
8. Use of a sulbactam according to any one of claims 1 to 7 for the preparation of a skin care product, characterized in that: the sulpirin is applied to skin care products.
9. The use of a sulbactam according to claim 8 for the preparation of a skin care product, characterized in that: the addition amount of the sulbactam in the skin care product is 0.1-5%.
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