CN115515984A - 一种抗cd19抗体的抗体及其制备和应用 - Google Patents

一种抗cd19抗体的抗体及其制备和应用 Download PDF

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CN115515984A
CN115515984A CN202180033343.6A CN202180033343A CN115515984A CN 115515984 A CN115515984 A CN 115515984A CN 202180033343 A CN202180033343 A CN 202180033343A CN 115515984 A CN115515984 A CN 115515984A
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antibody
seq
variable region
chain variable
light chain
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马安云
叶迅
沈连军
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Genxi Biotechnology Shanghai Co ltd
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Genxi Biotechnology Shanghai Co ltd
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/46Cellular immunotherapy
    • A61K39/463Cellular immunotherapy characterised by recombinant expression
    • A61K39/4631Chimeric Antigen Receptors [CAR]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/395Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K39/461Cellular immunotherapy characterised by the cell type used
    • A61K39/4611T-cells, e.g. tumor infiltrating lymphocytes [TIL], lymphokine-activated killer cells [LAK] or regulatory T cells [Treg]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/46Cellular immunotherapy
    • A61K39/464Cellular immunotherapy characterised by the antigen targeted or presented
    • A61K39/4643Vertebrate antigens
    • A61K39/4644Cancer antigens
    • A61K39/464402Receptors, cell surface antigens or cell surface determinants
    • A61K39/464411Immunoglobulin superfamily
    • A61K39/464412CD19 or B4
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
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    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/11DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
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    • C12N5/00Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/10Cells modified by introduction of foreign genetic material
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    • C12P21/00Preparation of peptides or proteins
    • C12P21/02Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione

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Abstract

一种靶向CD19抗体的抗体、其制备方法和用途。具体地,一种新的靶向CD19抗体的抗体。制备所述的单克隆抗体的方法。单克隆抗体能够高特异性地结合CD19抗体并阻断CD19抗体的功能。

Description

PCT国内申请,说明书已公开。

Claims (15)

  1. PCT国内申请,权利要求书已公开。
CN202180033343.6A 2020-05-08 2021-05-06 一种抗cd19抗体的抗体及其制备和应用 Pending CN115515984A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CN202010383916 2020-05-08
CN2020103839165 2020-05-08
PCT/CN2021/091955 WO2021223719A1 (zh) 2020-05-08 2021-05-06 一种抗cd19抗体的抗体及其制备和应用

Publications (1)

Publication Number Publication Date
CN115515984A true CN115515984A (zh) 2022-12-23

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CN202180033343.6A Pending CN115515984A (zh) 2020-05-08 2021-05-06 一种抗cd19抗体的抗体及其制备和应用

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CN (1) CN115515984A (zh)
TW (1) TWI800824B (zh)
WO (1) WO2021223719A1 (zh)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN116640216A (zh) * 2023-07-20 2023-08-25 合源生物科技(天津)有限公司 抗cd19抗体的抗体、抗cd22抗体的抗体及其应用

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN114163538B (zh) * 2021-12-09 2023-10-20 深圳先进技术研究院 同时靶向gpc3和cd276的嵌合抗原受体、嵌合抗原受体t细胞及其制备方法和应用
CN117402252A (zh) * 2022-07-06 2024-01-16 苏州星湾生物科技有限公司 抗cd20抗体的单克隆抗体及其应用

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20090220501A1 (en) * 2006-01-30 2009-09-03 Fey Georg H Anti-CD19 Antibody, Immunotoxin and Treatment Method
TWI529247B (zh) * 2009-05-13 2016-04-11 建新公司 抗人類cd52免疫球蛋白
US8790651B2 (en) * 2011-07-21 2014-07-29 Zoetis Llc Interleukin-31 monoclonal antibody
CN107556386A (zh) * 2016-06-30 2018-01-09 中国科学院深圳先进技术研究院 抗EGFRvIII和CD3特异性双靶向抗体、含双靶向抗体表达盒的微环DNA及应用
CN111848801B (zh) * 2016-09-06 2022-10-11 上海吉倍生物技术有限公司 一种抗cd19抗体及其制备方法和用途
CN107188964A (zh) * 2016-12-15 2017-09-22 上海科医联创生物科技有限公司 全人源抗cd19单克隆抗体及其生产方法
CN108727497A (zh) * 2017-04-17 2018-11-02 沈阳美达博生物科技有限公司 一种cd19抗体及其应用
CN107880128B (zh) * 2017-12-21 2021-03-02 常州费洛斯药业科技有限公司 一种抗cd19的全人源抗体或抗体片段及其方法和应用
CN108047332B (zh) * 2018-01-15 2021-08-24 阿思科力(苏州)生物科技有限公司 以cd19为靶点的特异性抗体、car-nk细胞及其制备和应用

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN116640216A (zh) * 2023-07-20 2023-08-25 合源生物科技(天津)有限公司 抗cd19抗体的抗体、抗cd22抗体的抗体及其应用
CN116640216B (zh) * 2023-07-20 2023-11-10 合源生物科技(天津)有限公司 抗cd19抗体的抗体、抗cd22抗体的抗体及其应用

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TWI800824B (zh) 2023-05-01
WO2021223719A1 (zh) 2021-11-11
TW202144435A (zh) 2021-12-01

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