TWI800824B - 一種抗cd19抗體的抗體及其製備和應用 - Google Patents

一種抗cd19抗體的抗體及其製備和應用 Download PDF

Info

Publication number
TWI800824B
TWI800824B TW110116445A TW110116445A TWI800824B TW I800824 B TWI800824 B TW I800824B TW 110116445 A TW110116445 A TW 110116445A TW 110116445 A TW110116445 A TW 110116445A TW I800824 B TWI800824 B TW I800824B
Authority
TW
Taiwan
Prior art keywords
antibody
preparation
application
antibody antibody
Prior art date
Application number
TW110116445A
Other languages
English (en)
Other versions
TW202144435A (zh
Inventor
馬安雲
葉迅
連軍 沈
Original Assignee
大陸商亘喜生物科技（上海）有限公司
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 大陸商亘喜生物科技（上海）有限公司 filed Critical 大陸商亘喜生物科技（上海）有限公司
Publication of TW202144435A publication Critical patent/TW202144435A/zh
Application granted granted Critical
Publication of TWI800824B publication Critical patent/TWI800824B/zh

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/46—Cellular immunotherapy
    • A61K39/463—Cellular immunotherapy characterised by recombinant expression
    • A61K39/4631—Chimeric Antigen Receptors [CAR]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/46—Cellular immunotherapy
    • A61K39/461—Cellular immunotherapy characterised by the cell type used
    • A61K39/4611—T-cells, e.g. tumor infiltrating lymphocytes [TIL], lymphokine-activated killer cells [LAK] or regulatory T cells [Treg]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/46—Cellular immunotherapy
    • A61K39/464—Cellular immunotherapy characterised by the antigen targeted or presented
    • A61K39/4643—Vertebrate antigens
    • A61K39/4644—Cancer antigens
    • A61K39/464402—Receptors, cell surface antigens or cell surface determinants
    • A61K39/464411—Immunoglobulin superfamily
    • A61K39/464412—CD19 or B4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/62—DNA sequences coding for fusion proteins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/10—Cells modified by introduction of foreign genetic material
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • Immunology (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biochemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Cell Biology (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
TW110116445A 2020-05-08 2021-05-06 一種抗cd19抗體的抗體及其製備和應用 TWI800824B (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CNCN202010383916.5 2020-05-08
CN202010383916 2020-05-08

Publications (2)

Publication Number Publication Date
TW202144435A TW202144435A (zh) 2021-12-01
TWI800824B true TWI800824B (zh) 2023-05-01

Family

ID=78468643

Family Applications (1)

Application Number Title Priority Date Filing Date
TW110116445A TWI800824B (zh) 2020-05-08 2021-05-06 一種抗cd19抗體的抗體及其製備和應用

Country Status (3)

Country Link
CN (1) CN115515984A (zh)
TW (1) TWI800824B (zh)
WO (1) WO2021223719A1 (zh)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN114163538B (zh) * 2021-12-09 2023-10-20 深圳先进技术研究院 同时靶向gpc3和cd276的嵌合抗原受体、嵌合抗原受体t细胞及其制备方法和应用
CN117402252A (zh) * 2022-07-06 2024-01-16 苏州星湾生物科技有限公司 抗cd20抗体的单克隆抗体及其应用
CN116640216B (zh) * 2023-07-20 2023-11-10 合源生物科技(天津)有限公司 抗cd19抗体的抗体、抗cd22抗体的抗体及其应用

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20090220501A1 (en) * 2006-01-30 2009-09-03 Fey Georg H Anti-CD19 Antibody, Immunotoxin and Treatment Method

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3683317A3 (en) * 2009-05-13 2020-09-30 Genzyme Corporation Anti-human cd52 immunoglobulins
US8790651B2 (en) * 2011-07-21 2014-07-29 Zoetis Llc Interleukin-31 monoclonal antibody
CN107556386A (zh) * 2016-06-30 2018-01-09 中国科学院深圳先进技术研究院 抗EGFRvIII和CD3特异性双靶向抗体、含双靶向抗体表达盒的微环DNA及应用
CN111848801B (zh) * 2016-09-06 2022-10-11 上海吉倍生物技术有限公司 一种抗cd19抗体及其制备方法和用途
CN107188964A (zh) * 2016-12-15 2017-09-22 上海科医联创生物科技有限公司 全人源抗cd19单克隆抗体及其生产方法
CN108727497A (zh) * 2017-04-17 2018-11-02 沈阳美达博生物科技有限公司 一种cd19抗体及其应用
CN107880128B (zh) * 2017-12-21 2021-03-02 常州费洛斯药业科技有限公司 一种抗cd19的全人源抗体或抗体片段及其方法和应用
CN108047332B (zh) * 2018-01-15 2021-08-24 阿思科力(苏州)生物科技有限公司 以cd19为靶点的特异性抗体、car-nk细胞及其制备和应用

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20090220501A1 (en) * 2006-01-30 2009-09-03 Fey Georg H Anti-CD19 Antibody, Immunotoxin and Treatment Method

Also Published As

Publication number Publication date
WO2021223719A1 (zh) 2021-11-11
TW202144435A (zh) 2021-12-01
CN115515984A (zh) 2022-12-23

Similar Documents

Publication Publication Date Title
TWI800824B (zh) 一種抗cd19抗體的抗體及其製備和應用
GB202019709D0 (en) Anti-Coronavirus antibodies and methods of use
MA52773A (fr) Anticorps anti-cd3 et leurs utilisations
EP4219554A4 (en) HUMANIZED CD7-TARGETED ANTIBODY AND USE THEREOF
MA51223A (fr) Formulation lyophilisée d'un anticorps monoclonal contre la transthyrétine
DK3618928T3 (da) Anti-Sortilin-antistoffer og fremgangsmåder til anvendelse deraf
MA49398A (fr) Anticorps monoclonaux anti-igf-1r et utilisations de ceux-ci
ES2969235T3 (es) Anticuerpo monoclonal que antagoniza e inhibe la unión del antígeno PD-1 humano a su ligando, método de preparación del mismo y aplicación del mismo
GB202201160D0 (en) Anti-tau antibody and use of same
EP4095160A4 (en) ANTI-ST2 ANTIBODIES AND ITS APPLICATION
MA52212A (fr) Anticorps multivalent
EP4151652A4 (en) ANTI-CD73 ANTIBODIES AND USE THEREOF
ZA202104280B (en) Bispecific single-chain antibody and application
EP4039708A4 (en) ANTI-CLL1 ANTIBODIES AND ITS USE
EP4095157A4 (en) ANTI-ANGPTL3 ANTIBODIES AND ITS USE
IL306043A (en) Anti-CD19 antibodies and chimeric T-antigen receptor constructs
CL2023001064A1 (es) Proteína de unión al antígeno anti-steap1
DK3532098T3 (da) Kombination af anti-cd19-antistof med en bcl-2-inhibitor og anvendelser deraf
EP4061847A4 (en) ANTI-B7-H3 MONOCLONAL ANTIBODY AND METHODS OF USE THEREOF
MA52485A (fr) Combinaisons de variants d'anticorps et utilisations associées
IL310432A (en) Antibodies and antibody conjugates specific for nectin-4 and methods of using them
IL308260A (en) Antibodies against Tigit and methods of using them
TWI799791B (zh) 構造體及其製造方法
EP4234580A4 (en) ANTIBODIES TARGETING NKG2A AND ITS USE
EP4169950A4 (en) ANTI-LILRB1 ANTIBODIES AND ITS USES