CN115508166B - Leucorrhea sample preprocessing device based on special structure test tube - Google Patents

Leucorrhea sample preprocessing device based on special structure test tube Download PDF

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Publication number
CN115508166B
CN115508166B CN202211302048.9A CN202211302048A CN115508166B CN 115508166 B CN115508166 B CN 115508166B CN 202211302048 A CN202211302048 A CN 202211302048A CN 115508166 B CN115508166 B CN 115508166B
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test tube
cotton swab
sample
cavity
sample liquid
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CN115508166A (en
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梁湘辉
梁光明
危加胜
刘济群
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Hunan Youzhe Technology Co ltd
Xiangya Hospital of Central South University
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Hunan Youzhe Technology Co ltd
Xiangya Hospital of Central South University
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    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00Sampling; Preparing specimens for investigation
    • G01N1/28Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B10/00Other methods or instruments for diagnosis, e.g. instruments for taking a cell sample, for biopsy, for vaccination diagnosis; Sex determination; Ovulation-period determination; Throat striking implements
    • A61B10/0045Devices for taking samples of body liquids
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/508Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above
    • B01L3/5082Test tubes per se
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00Sampling; Preparing specimens for investigation
    • G01N1/28Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
    • G01N1/38Diluting, dispersing or mixing samples
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B10/00Other methods or instruments for diagnosis, e.g. instruments for taking a cell sample, for biopsy, for vaccination diagnosis; Sex determination; Ovulation-period determination; Throat striking implements
    • A61B10/0045Devices for taking samples of body liquids
    • A61B2010/0074Vaginal or cervical secretions

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  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Pathology (AREA)
  • Hematology (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • Physics & Mathematics (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Medical Informatics (AREA)
  • Engineering & Computer Science (AREA)
  • Surgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Clinical Laboratory Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Sampling And Sample Adjustment (AREA)

Abstract

The invention discloses a leucorrhea specimen pretreatment device based on a test tube with a specific structure, which belongs to the field of medical instruments and comprises the following components: test tube, test tube includes: test tube lid, test tube body and cotton swab, test tube lid connects at the top of test tube body, and the cotton swab runs through the test tube lid and stretches into in the test tube, is provided with cotton swab stirring mouth and rifle head sample connection on the test tube lid, is provided with the direction inward side between cotton swab stirring mouth and the rifle head sample connection, and the one end that the rifle head sample connection was kept away from to the cotton swab stirring mouth is provided with spacing limit, is provided with cotton swab mixing cavity, the through cavity of sample liquid and sample liquid sample cavity in the test tube, and cotton swab mixing cavity, the through cavity of sample liquid and sample liquid sample cavity communicate each other. According to the test tube disclosed by the invention, the mixing position and the sampling position of the sample liquid are separated, so that the mixing process and the sampling process are not interfered with each other. After avoiding traditional equipment mixing, need open the lid, take out the cotton swab of wherein again inhale the mode of appearance, saved uncapping mechanism, reduced equipment cost.

Description

Leucorrhea sample preprocessing device based on special structure test tube
Technical Field
The invention belongs to the field of medical instruments, and particularly relates to a leucorrhea specimen pretreatment device based on a test tube with a specific structure.
Background
Currently, the pretreatment forms of leucorrhea specimens are generally divided into two types, one is a manual form and the other is an automatic form. The manual mode is that the cotton swab sample is manually placed in a PP soft test tube, diluent is manually injected, the cotton swab is pinched by hands to perform sample elution and mixing, then the diluted and dissolved liquid sample is poured into a short test tube which can be processed by a machine, placed at a sample feeding position of an instrument, and moved to a detection position to perform sampling treatment. The automatic form is that a pretreatment structure is added to realize automatic dilution and shaking of the sample, then the cotton swab is broken, the cotton swab rod is discarded, the cotton swab head is reserved in sample liquid, and the sample liquid is sent to a detection position for sampling treatment.
Problems with existing manual formats: first, the sample solution is easy to cause cross infection due to manual contact. Secondly, in the process of hand pinching, the situation of incomplete mixing is easy to occur due to the emotion of staff and the like in the process of mixing by the manual experience and professional operation of the staff. Thirdly, the liquid is transferred, and the liquid pouring process can be poured out, so that the pollution of the working site is formed.
Problems with existing automated formats: most of the existing devices in the market adopt cotton swab sampling and same-port devices, and the diluting liquid needs to be added for puncturing or uncovering; the cotton swab is stirred and then sucked, and the cotton swab is required to be automatically uncapped once, so that the pretreatment equipment is required to be provided with a complicated uncapping mechanism, the cost is increased, and the reliability of the instrument is reduced.
Disclosure of Invention
The invention aims to provide a leucorrhea specimen pretreatment device based on a test tube with a specific structure, which solves the defects in the prior art.
In order to achieve the aim of the invention, the invention adopts the following technical scheme:
a leucorrhea specimen pretreatment device based on a special structure test tube, comprising: a cuvette, the cuvette comprising: test tube lid, test tube body and cotton swab, the test tube lid is connected the top of test tube body, the cotton swab runs through the test tube lid stretches into in the test tube body, be provided with cotton swab stirring mouth and rifle head sample connection on the test tube lid, be provided with the direction inward side between cotton swab stirring mouth and the rifle head sample connection, the cotton swab stirring mouth is kept away from the one end of rifle head sample connection is provided with spacing limit, be provided with cotton swab mixing cavity, the straight cavity of sample liquid and sample liquid sample cavity in the test tube body, cotton swab mixing cavity, the straight cavity of sample liquid and sample liquid sample cavity communicate each other.
Preferably, the upper end of the cotton swab stirring port is a straight-through small port, the lower end of the cotton swab stirring port is a conical port, and the gun head sampling port is positioned at the side low position of the cotton swab stirring port.
Preferably, the lower extension of the guiding inner edge exceeds the bottom end of the test tube cover.
Preferably, the pretreatment device further comprises a pretreatment mechanism, wherein the pretreatment mechanism comprises a workbench, sample feeding equipment is arranged on the workbench, a test tube rack is arranged on the sample feeding equipment, the test tube is arranged in the test tube rack, and a sampling arm is arranged above the workbench.
Preferably, the sampling arm includes: the device comprises a frame, wherein a screw motor is arranged at the top end of the frame, a sliding block is connected with the output end of the screw motor in a threaded manner, a rotating motor is fixedly connected to the sliding block, a uniformly-mixed rotating head is fixedly connected to the output end of the rotating motor, and a diluting needle is further arranged on the sliding block.
Preferably, a guide rail is further arranged on the inner wall of the frame, and the guide rail is in sliding fit with the sliding block.
Preferably, the middle part of workstation is discernment station, discernment station is provided with sensor and sweeps the sign indicating number ware, the sensor is used for detecting whether there is the test tube to pass through, sweep the sign indicating number ware and be used for reading the bar code numerical value on the test tube.
Compared with the prior art, the leucorrhea specimen pretreatment device based on the test tube with the specific structure has the following advantages:
(1) According to the test tube disclosed by the invention, the mixing position and the sampling position of the sample liquid are separated, so that the mixing process and the sampling process are not interfered with each other. After avoiding traditional equipment mixing, need open the lid, take out the cotton swab of wherein again inhale the mode of appearance, saved uncapping mechanism, reduced equipment cost.
(2) According to the invention, the sample is uniformly mixed by rotating the cotton swab through the uniformly mixing rotary head, so that the mode of pinching the test tube by hands before is changed, the hands are liberated, and the probability of contact infection is reduced.
Drawings
In order to more clearly illustrate the embodiments of the present invention or the technical solutions in the prior art, the drawings that are required to be used in the embodiments or the description of the prior art will be briefly described below, and it is obvious that the drawings in the following description are only embodiments of the present invention, and that other drawings can be obtained according to the provided drawings without inventive effort for a person skilled in the art.
FIG. 1 is a schematic view of the structure of a test tube according to the present invention;
FIG. 2 is a top view of the cuvette of the present invention;
FIG. 3 is a front cross-sectional view of the test tube cap of the present invention;
FIG. 4 is a front cross-sectional view of the test tube of the present invention;
fig. 5 is a schematic diagram of the overall structure of the present invention.
In the figure: 1-test tube, 11-test tube cover, 111-cotton swab stirring port, 112-gun head sampling port, 113-guiding inner edge, 114-limiting edge, 12-test tube body, 121-sample liquid through cavity, 122-sample liquid sampling cavity, 123-cotton swab mixing cavity, 13-cotton swab, 2-sampling arm, 21-mixing rotating head, 22-rotating motor, 23-screw motor, 24-diluting needle, 3-sample feeding device, 31-sensor, 32-code scanner and 4-test tube rack.
Detailed Description
The technical scheme of the invention is further described below with reference to the accompanying drawings and examples:
referring to FIGS. 1-5, the present invention provides a leucorrhea specimen pretreatment device based on a test tube with a specific structure, comprising: test tube 1, said test tube 1 comprising: test tube lid 11, test tube body 12 and cotton swab 13, test tube lid 11 connects the top of test tube 12 body, cotton swab 13 runs through test tube lid 11 stretches into in the test tube body 12, test tube lid 11 has set gradually cotton swab stirring mouth 111 and rifle head sampling mouth 112 from left to right, be provided with direction inward side 113 between cotton swab stirring mouth 111 and the rifle head sampling mouth 112, cotton swab stirring mouth 111 is kept away from the one end of rifle head sampling mouth 112 is provided with spacing limit 114, test tube body 12 has set gradually cotton swab mixing cavity 123, straight through sample liquid cavity 121 and sample liquid sampling cavity 122 from left to right, cotton swab mixing cavity 123, straight through sample liquid cavity 121 and sample liquid sampling cavity 122 communicate each other. The limiting edge 114 is clamped with the flange of the test tube rack 4, so that the situation that the position is uncontrollable due to the fact that the test tube cover 11 is taken out of the test tube rack when the sliding block is displaced upwards is prevented.
As a preferred embodiment, the upper end of the cotton swab stirring port 111 is a through small port, the lower end is a conical port, and the gun head sampling port 112 is positioned at a lower side of the cotton swab stirring port 111. The distance from the gun head sampling port 112 to the bottom surface of the test tube 1 is low, so that the time required for the up-down of the device during sampling can be reduced.
As a preferred embodiment, the lower extension of the guiding inner edge 113 exceeds the bottom end of the tube cover 11. The guiding inner edge 113 is used for limiting the downward moving direction of the gun head and improving the stability of the gun head in the downward moving sampling process.
As a preferred embodiment, the device further comprises a pretreatment mechanism, wherein the pretreatment mechanism comprises a workbench, a sample feeding device 3 is arranged on the workbench, a test tube rack 4 is arranged on the sample feeding device 3, the test tube 1 is arranged in the test tube rack 4, and a sampling arm 2 is arranged above the workbench. The sampling arm 2 includes: the machine comprises a frame, wherein a screw motor 23 is arranged at the top end of the frame, a sliding block is connected with the output end of the screw motor 23 in a threaded manner, a rotating motor 22 is fixedly connected to the sliding block, a uniformly-mixed rotating head 21 is fixedly connected to the output end of the rotating motor 22, and a diluting needle 24 is further arranged on the sliding block. The inner wall of the frame is also provided with a guide rail which is in sliding fit with the sliding block. The middle part of workstation is discernment station, discernment station is provided with sensor 31 and sweeps a yard ware 32, sensor 31 is used for detecting whether there is test tube 1 to pass through, sweep a yard ware 32 and be used for reading the bar code numerical value on the test tube 1.
The working principle of the invention is as follows:
by pushing the sample conveying device 3, the test tube 1 moves to the identification station along with the test tube rack 4, and the sensor 31 judges whether the test tube 1 exists on the station after optical detection. The test tube 1 is judged to be present, and the sampling arm 2 starts to move to the upper side of the test tube 1 for the next operation.
The screw motor 23 is started to drive the sliding block to move downwards, and the mixing rotary head 21 is opposite to the cotton swab stirring port 111 of the test tube 1, and after the cotton swab stirring port 111 of the test tube 1 is broken, the cotton swab rod with a set length is arranged. While the mixing rotary head 21 faces the cotton swab head, a diluting needle 24 is obliquely arranged on the sliding block, the diluting needle 24 faces the gun head sampling port 112 of the test tube 1, the upper end of the diluting needle 24 is connected with a peristaltic pump through a pipe, and the other end of the peristaltic pump is connected with a diluent bottle. The inner hole of the mixing rotary head 21 is provided with a clamping mechanism and an anti-rotation bottom surface, at this time, the inner hole of the mixing rotary head 21 is connected with a cotton swab rod, then the rotary motor 22 is started, and the cotton swab 13 can rapidly rotate along with the mixing rotary head 21.
The cotton head at the lower part of the cotton swab 13 is carried to rotate in the diluent, the diluent at the bottom of the test tube 1 is stirred by the rapid rotation of the cotton swab 13, and the bottom of the test tube 1 is provided with two cavities, and the shape is specific, so that the diluent stirred by the cotton swab 13 does not perform circular motion, and the turbulence of the liquid in the test tube 1 is caused, so that the surface of the cotton swab 13 is continuously flushed. Meanwhile, the cotton swab 13 rotates and continuously contacts with the diluting liquid, and a sample falls off from the cotton swab 13 in the contact process, so that the sample is uniformly mixed in the diluting liquid in the test tube 1 to form the sample liquid required by detection.
After the mixing is carried out for a set time, the screw motor 23 of the sampling arm 2 drives the sliding block to move upwards, and the cotton swab 13 and the cotton swab rod are separated from the mixing rotating head 21. And (5) uniformly mixing to finish the process.
In the description of the present application, it should be noted that the azimuth or positional relationship indicated by the terms "upper", "lower", etc. are based on the azimuth or positional relationship shown in the drawings, and are merely for convenience of description of the present application and simplification of the description, and are not indicative or implying that the apparatus or element in question must have a specific azimuth, be configured and operated in a specific azimuth, and thus should not be construed as limiting the present application. Unless specifically stated or limited otherwise, the terms "mounted," "connected," and "coupled" are to be construed broadly, and may be, for example, fixedly connected, detachably connected, or integrally connected; can be mechanically or electrically connected; can be directly connected or indirectly connected through an intermediate medium, and can be communication between two elements. The specific meaning of the terms in this application will be understood by those of ordinary skill in the art as the case may be.
It should be noted that in this application, relational terms such as "first" and "second" and the like are used solely to distinguish one entity or action from another entity or action without necessarily requiring or implying any actual such relationship or order between such entities or actions. Moreover, the terms "comprises," "comprising," or any other variation thereof, are intended to cover a non-exclusive inclusion, such that a process, method, article, or apparatus that comprises a list of elements does not include only those elements but may include other elements not expressly listed or inherent to such process, method, article, or apparatus. Without further limitation, an element defined by the phrase "comprising one … …" does not exclude the presence of other like elements in a process, method, article, or apparatus that comprises the element.
The foregoing is merely a specific embodiment of the application to enable one skilled in the art to understand or practice the application. Various modifications to these embodiments will be readily apparent to those skilled in the art, and the generic principles defined herein may be applied to other embodiments without departing from the spirit or scope of the application. Thus, the present application is not intended to be limited to the embodiments shown herein but is to be accorded the widest scope consistent with the principles and novel features disclosed herein.

Claims (5)

1. A leucorrhea specimen pretreatment device based on a special structure test tube, comprising: test tube (1), characterized in that said test tube (1) comprises: test tube lid (11), test tube body (12) and cotton swab (13), test tube lid (11) are connected the top of test tube (12) body, cotton swab (13) run through test tube lid (11) and stretch into in test tube body (12), be provided with cotton swab stirring mouth (111) and rifle head sample connection (112) on test tube lid (11), be provided with between cotton swab stirring mouth (111) and rifle head sample connection (112) and lead to interior limit (113), the one end that rifle head sample connection (112) were kept away from to cotton swab stirring mouth (111) is provided with spacing limit (114), be provided with cotton swab mixing cavity (123), sample liquid through cavity (121) and sample liquid sample cavity (122) in test tube body (12), cotton swab mixing cavity (123), sample liquid through cavity (121) and sample liquid sample cavity (122) communicate each other.
The upper end of the cotton swab stirring port (111) is a straight-through small port, the lower end of the cotton swab stirring port is a conical port, and the gun head sampling port (112) is positioned at the lower side of the cotton swab stirring port (111);
the lower extension of the guiding inner edge (113) exceeds the bottom end of the test tube cover (11).
2. The leucorrhea specimen pretreatment device based on the special structure test tube according to claim 1, further comprising a pretreatment mechanism, wherein the pretreatment mechanism comprises a workbench, a sample feeding device (3) is arranged on the workbench, a test tube rack (4) is arranged on the sample feeding device (3), the test tube (1) is arranged in the test tube rack (4), and a sampling arm (2) is arranged above the workbench.
3. A leucorrhea specimen pretreatment device based on special structure test tubes according to claim 2, characterized in that the sampling arm (2) comprises: the device comprises a frame, wherein a screw motor (23) is arranged at the top end of the frame, a sliding block is connected with the output end of the screw motor (23) in a threaded manner, a rotating motor (22) is fixedly connected to the sliding block, a uniformly-mixed rotating head (21) is fixedly connected to the output end of the rotating motor (22), and a diluting needle (24) is further arranged on the sliding block.
4. A leucorrhea specimen pretreatment device based on a test tube with a special structure according to claim 3, wherein a guide rail is further arranged on the inner wall of the frame, and the guide rail is in sliding fit with the slide block.
5. The leucorrhea specimen pretreatment device based on the test tube with the special structure according to claim 2, wherein the middle part of the workbench is a recognition station, the recognition station is provided with a sensor (31) and a code scanner (32), the sensor (31) is used for detecting whether the test tube (1) passes through or not, and the code scanner (32) is used for reading bar code values on the test tube (1).
CN202211302048.9A 2022-10-24 2022-10-24 Leucorrhea sample preprocessing device based on special structure test tube Active CN115508166B (en)

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CN202211302048.9A CN115508166B (en) 2022-10-24 2022-10-24 Leucorrhea sample preprocessing device based on special structure test tube

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CN202211302048.9A CN115508166B (en) 2022-10-24 2022-10-24 Leucorrhea sample preprocessing device based on special structure test tube

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CN115508166B true CN115508166B (en) 2023-07-14

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Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR3043783B1 (en) * 2015-11-13 2017-12-08 Horiba Abx Sas STIRRING AND SAMPLING DEVICE FOR SAMPLE BIOLOGICAL LIQUIDS SUITABLE FOR SORTING
CN105997156B (en) * 2016-06-12 2023-05-26 杭州昕龙医疗科技有限公司 Sampling swab capable of being used for full-automatic pretreatment
CN111207946A (en) * 2020-03-12 2020-05-29 珠海科域生物工程股份有限公司 Disposable specimen collecting cup and puncturing and uniformly mixing method thereof
CN111830267A (en) * 2020-08-14 2020-10-27 深圳市瀚德标检生物工程有限公司 Pretreatment system for vaginal secretion sample detection
CN114324947A (en) * 2020-09-29 2022-04-12 江苏百英吉生命科学技术有限公司 Detection system for detecting biological fluid sample
CN112180106A (en) * 2020-10-15 2021-01-05 珠海科域生物工程股份有限公司 Puncture liquid feeding mixing machine
CN114646523A (en) * 2020-12-17 2022-06-21 深圳市帝迈生物技术有限公司 Blending device and sample analyzer

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