CN115487113A - Emulsion containing clove fruit extract and preparation method and application thereof - Google Patents
Emulsion containing clove fruit extract and preparation method and application thereof Download PDFInfo
- Publication number
- CN115487113A CN115487113A CN202211178490.5A CN202211178490A CN115487113A CN 115487113 A CN115487113 A CN 115487113A CN 202211178490 A CN202211178490 A CN 202211178490A CN 115487113 A CN115487113 A CN 115487113A
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- parts
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- clove
- emulsion
- extract
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- 244000223014 Syzygium aromaticum Species 0.000 title claims abstract description 101
- 235000016639 Syzygium aromaticum Nutrition 0.000 title claims abstract description 101
- 235000013399 edible fruits Nutrition 0.000 title claims abstract description 98
- 239000000839 emulsion Substances 0.000 title claims abstract description 71
- 239000000284 extract Substances 0.000 title claims abstract description 45
- 238000002360 preparation method Methods 0.000 title claims description 13
- 238000000605 extraction Methods 0.000 title description 10
- 239000002537 cosmetic Substances 0.000 claims abstract description 15
- 239000011159 matrix material Substances 0.000 claims abstract description 15
- 230000003078 antioxidant effect Effects 0.000 claims abstract description 4
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 82
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 66
- PUPZLCDOIYMWBV-UHFFFAOYSA-N (+/-)-1,3-Butanediol Chemical compound CC(O)CCO PUPZLCDOIYMWBV-UHFFFAOYSA-N 0.000 claims description 46
- 239000002024 ethyl acetate extract Substances 0.000 claims description 40
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims description 39
- LXCFILQKKLGQFO-UHFFFAOYSA-N methylparaben Chemical compound COC(=O)C1=CC=C(O)C=C1 LXCFILQKKLGQFO-UHFFFAOYSA-N 0.000 claims description 38
- 229960005150 glycerol Drugs 0.000 claims description 31
- 235000011187 glycerol Nutrition 0.000 claims description 31
- 238000003756 stirring Methods 0.000 claims description 27
- 229920001285 xanthan gum Polymers 0.000 claims description 26
- 239000000230 xanthan gum Substances 0.000 claims description 26
- 229940082509 xanthan gum Drugs 0.000 claims description 26
- 235000010493 xanthan gum Nutrition 0.000 claims description 26
- FYGDTMLNYKFZSV-URKRLVJHSA-N (2s,3r,4s,5s,6r)-2-[(2r,4r,5r,6s)-4,5-dihydroxy-2-(hydroxymethyl)-6-[(2r,4r,5r,6s)-4,5,6-trihydroxy-2-(hydroxymethyl)oxan-3-yl]oxyoxan-3-yl]oxy-6-(hydroxymethyl)oxane-3,4,5-triol Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1OC1[C@@H](CO)O[C@@H](OC2[C@H](O[C@H](O)[C@H](O)[C@H]2O)CO)[C@H](O)[C@H]1O FYGDTMLNYKFZSV-URKRLVJHSA-N 0.000 claims description 21
- 229920002498 Beta-glucan Polymers 0.000 claims description 21
- OMIGHNLMNHATMP-UHFFFAOYSA-N 2-hydroxyethyl prop-2-enoate Chemical compound OCCOC(=O)C=C OMIGHNLMNHATMP-UHFFFAOYSA-N 0.000 claims description 19
- LEACJMVNYZDSKR-UHFFFAOYSA-N 2-octyldodecan-1-ol Chemical compound CCCCCCCCCCC(CO)CCCCCCCC LEACJMVNYZDSKR-UHFFFAOYSA-N 0.000 claims description 19
- YBGZDTIWKVFICR-JLHYYAGUSA-N Octyl 4-methoxycinnamic acid Chemical compound CCCCC(CC)COC(=O)\C=C\C1=CC=C(OC)C=C1 YBGZDTIWKVFICR-JLHYYAGUSA-N 0.000 claims description 19
- 235000021355 Stearic acid Nutrition 0.000 claims description 19
- BTFJIXJJCSYFAL-UHFFFAOYSA-N arachidyl alcohol Natural products CCCCCCCCCCCCCCCCCCCCO BTFJIXJJCSYFAL-UHFFFAOYSA-N 0.000 claims description 19
- 239000004292 methyl p-hydroxybenzoate Substances 0.000 claims description 19
- 235000010270 methyl p-hydroxybenzoate Nutrition 0.000 claims description 19
- 229960002216 methylparaben Drugs 0.000 claims description 19
- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 claims description 19
- OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 claims description 19
- 229960001679 octinoxate Drugs 0.000 claims description 19
- 239000008117 stearic acid Substances 0.000 claims description 19
- SHOKSIZSCQFIRY-UHFFFAOYSA-N [3-(2-tert-butyl-2-hydroxy-4,4-dimethyl-3-phenylpentanoyl)oxy-2,2-bis[(2-tert-butyl-2-hydroxy-4,4-dimethyl-3-phenylpentanoyl)oxymethyl]propyl] 2-tert-butyl-2-hydroxy-4,4-dimethyl-3-phenylpentanoate Chemical compound C=1C=CC=CC=1C(C(C)(C)C)C(O)(C(C)(C)C)C(=O)OCC(COC(=O)C(O)(C(C=1C=CC=CC=1)C(C)(C)C)C(C)(C)C)(COC(=O)C(O)(C(C=1C=CC=CC=1)C(C)(C)C)C(C)(C)C)COC(=O)C(O)(C(C)(C)C)C(C(C)(C)C)C1=CC=CC=C1 SHOKSIZSCQFIRY-UHFFFAOYSA-N 0.000 claims description 14
- 239000002994 raw material Substances 0.000 claims description 14
- LXAHHHIGZXPRKQ-UHFFFAOYSA-N 5-fluoro-2-methylpyridine Chemical compound CC1=CC=C(F)C=N1 LXAHHHIGZXPRKQ-UHFFFAOYSA-N 0.000 claims description 13
- 238000000034 method Methods 0.000 claims description 13
- 239000007787 solid Substances 0.000 claims description 12
- 239000003109 Disodium ethylene diamine tetraacetate Substances 0.000 claims description 6
- ZGTMUACCHSMWAC-UHFFFAOYSA-L EDTA disodium salt (anhydrous) Chemical compound [Na+].[Na+].OC(=O)CN(CC([O-])=O)CCN(CC(O)=O)CC([O-])=O ZGTMUACCHSMWAC-UHFFFAOYSA-L 0.000 claims description 6
- 235000019301 disodium ethylene diamine tetraacetate Nutrition 0.000 claims description 6
- -1 pentaerythritol tetrakis (di-tert-butyl hydroxyhydrocinnamate) ester Chemical class 0.000 claims description 6
- 101000878595 Arabidopsis thaliana Squalene synthase 1 Proteins 0.000 claims description 5
- 230000001804 emulsifying effect Effects 0.000 claims description 5
- 239000006210 lotion Substances 0.000 claims description 5
- 238000002156 mixing Methods 0.000 claims description 5
- 230000004888 barrier function Effects 0.000 claims description 3
- 239000006071 cream Substances 0.000 claims description 3
- CDQSJQSWAWPGKG-UHFFFAOYSA-N butane-1,1-diol Chemical compound CCCC(O)O CDQSJQSWAWPGKG-UHFFFAOYSA-N 0.000 claims description 2
- 210000002966 serum Anatomy 0.000 claims description 2
- 230000037072 sun protection Effects 0.000 claims description 2
- 230000003020 moisturizing effect Effects 0.000 abstract description 31
- 230000005923 long-lasting effect Effects 0.000 abstract description 3
- 230000002087 whitening effect Effects 0.000 abstract description 3
- 239000012071 phase Substances 0.000 description 36
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 description 24
- 235000019437 butane-1,3-diol Nutrition 0.000 description 20
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 19
- 239000003921 oil Substances 0.000 description 18
- 239000003995 emulsifying agent Substances 0.000 description 16
- YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 description 15
- 238000012360 testing method Methods 0.000 description 14
- 230000000694 effects Effects 0.000 description 11
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 10
- 238000010438 heat treatment Methods 0.000 description 8
- 239000000126 substance Substances 0.000 description 8
- 241000700198 Cavia Species 0.000 description 6
- 235000019441 ethanol Nutrition 0.000 description 6
- 239000000463 material Substances 0.000 description 6
- 239000000516 sunscreening agent Substances 0.000 description 6
- 239000003814 drug Substances 0.000 description 5
- 238000004945 emulsification Methods 0.000 description 5
- 230000014759 maintenance of location Effects 0.000 description 5
- 239000000203 mixture Substances 0.000 description 5
- 239000003208 petroleum Substances 0.000 description 5
- 150000008442 polyphenolic compounds Chemical class 0.000 description 5
- 235000013824 polyphenols Nutrition 0.000 description 5
- 230000003064 anti-oxidating effect Effects 0.000 description 4
- 239000008367 deionised water Substances 0.000 description 4
- 229910021641 deionized water Inorganic materials 0.000 description 4
- 150000004676 glycans Chemical class 0.000 description 4
- 230000003647 oxidation Effects 0.000 description 4
- 238000007254 oxidation reaction Methods 0.000 description 4
- 229920001282 polysaccharide Polymers 0.000 description 4
- 239000005017 polysaccharide Substances 0.000 description 4
- 238000000638 solvent extraction Methods 0.000 description 4
- 229910021642 ultra pure water Inorganic materials 0.000 description 4
- 239000012498 ultrapure water Substances 0.000 description 4
- 241000193830 Bacillus <bacterium> Species 0.000 description 3
- 241000196324 Embryophyta Species 0.000 description 3
- 239000000654 additive Substances 0.000 description 3
- 238000013400 design of experiment Methods 0.000 description 3
- 239000003205 fragrance Substances 0.000 description 3
- 238000000265 homogenisation Methods 0.000 description 3
- ISWSIDIOOBJBQZ-UHFFFAOYSA-N Phenol Chemical compound OC1=CC=CC=C1 ISWSIDIOOBJBQZ-UHFFFAOYSA-N 0.000 description 2
- CDBYLPFSWZWCQE-UHFFFAOYSA-L Sodium Carbonate Chemical compound [Na+].[Na+].[O-]C([O-])=O CDBYLPFSWZWCQE-UHFFFAOYSA-L 0.000 description 2
- 230000000996 additive effect Effects 0.000 description 2
- 239000003674 animal food additive Substances 0.000 description 2
- 230000000843 anti-fungal effect Effects 0.000 description 2
- 229940121375 antifungal agent Drugs 0.000 description 2
- 244000052616 bacterial pathogen Species 0.000 description 2
- 230000015572 biosynthetic process Effects 0.000 description 2
- 150000001875 compounds Chemical class 0.000 description 2
- 238000005034 decoration Methods 0.000 description 2
- 238000001035 drying Methods 0.000 description 2
- 239000003792 electrolyte Substances 0.000 description 2
- 238000001704 evaporation Methods 0.000 description 2
- 230000008020 evaporation Effects 0.000 description 2
- 229930003935 flavonoid Natural products 0.000 description 2
- 150000002215 flavonoids Chemical class 0.000 description 2
- 235000017173 flavonoids Nutrition 0.000 description 2
- LNTHITQWFMADLM-UHFFFAOYSA-N gallic acid Chemical compound OC(=O)C1=CC(O)=C(O)C(O)=C1 LNTHITQWFMADLM-UHFFFAOYSA-N 0.000 description 2
- 238000000227 grinding Methods 0.000 description 2
- 238000000338 in vitro Methods 0.000 description 2
- 230000002045 lasting effect Effects 0.000 description 2
- 238000002386 leaching Methods 0.000 description 2
- 239000004973 liquid crystal related substance Substances 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 238000005259 measurement Methods 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 239000000047 product Substances 0.000 description 2
- 238000002390 rotary evaporation Methods 0.000 description 2
- 230000000475 sunscreen effect Effects 0.000 description 2
- 238000005303 weighing Methods 0.000 description 2
- 241000700199 Cavia porcellus Species 0.000 description 1
- 229920002261 Corn starch Polymers 0.000 description 1
- 229920000742 Cotton Polymers 0.000 description 1
- DSLZVSRJTYRBFB-LLEIAEIESA-L D-glucarate(2-) Chemical compound [O-]C(=O)[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C([O-])=O DSLZVSRJTYRBFB-LLEIAEIESA-L 0.000 description 1
- 241000233866 Fungi Species 0.000 description 1
- 241000287828 Gallus gallus Species 0.000 description 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 1
- 241000699670 Mus sp. Species 0.000 description 1
- 241000219926 Myrtaceae Species 0.000 description 1
- 240000004808 Saccharomyces cerevisiae Species 0.000 description 1
- 208000037386 Typhoid Diseases 0.000 description 1
- 230000000895 acaricidal effect Effects 0.000 description 1
- 239000004480 active ingredient Substances 0.000 description 1
- 150000001413 amino acids Chemical class 0.000 description 1
- RJGDLRCDCYRQOQ-UHFFFAOYSA-N anthrone Chemical compound C1=CC=C2C(=O)C3=CC=CC=C3CC2=C1 RJGDLRCDCYRQOQ-UHFFFAOYSA-N 0.000 description 1
- 239000003429 antifungal agent Substances 0.000 description 1
- 239000008346 aqueous phase Substances 0.000 description 1
- 238000003556 assay Methods 0.000 description 1
- 230000003385 bacteriostatic effect Effects 0.000 description 1
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 1
- 239000000919 ceramic Substances 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 239000010634 clove oil Substances 0.000 description 1
- 238000001816 cooling Methods 0.000 description 1
- 239000008120 corn starch Substances 0.000 description 1
- 238000005520 cutting process Methods 0.000 description 1
- 230000000254 damaging effect Effects 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 208000001848 dysentery Diseases 0.000 description 1
- 230000002708 enhancing effect Effects 0.000 description 1
- 230000007613 environmental effect Effects 0.000 description 1
- 239000000686 essence Substances 0.000 description 1
- 238000011049 filling Methods 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 229940074391 gallic acid Drugs 0.000 description 1
- 235000004515 gallic acid Nutrition 0.000 description 1
- 239000008103 glucose Substances 0.000 description 1
- 229930182478 glucoside Natural products 0.000 description 1
- 150000008131 glucosides Chemical class 0.000 description 1
- 239000004519 grease Substances 0.000 description 1
- 230000005764 inhibitory process Effects 0.000 description 1
- 239000000077 insect repellent Substances 0.000 description 1
- 210000003205 muscle Anatomy 0.000 description 1
- 231100000252 nontoxic Toxicity 0.000 description 1
- 230000003000 nontoxic effect Effects 0.000 description 1
- 239000002674 ointment Substances 0.000 description 1
- 230000000144 pharmacologic effect Effects 0.000 description 1
- 239000000419 plant extract Substances 0.000 description 1
- 239000005648 plant growth regulator Substances 0.000 description 1
- 239000004033 plastic Substances 0.000 description 1
- 229920000642 polymer Polymers 0.000 description 1
- 239000013641 positive control Substances 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 238000010298 pulverizing process Methods 0.000 description 1
- 238000005086 pumping Methods 0.000 description 1
- 230000002040 relaxant effect Effects 0.000 description 1
- 238000012216 screening Methods 0.000 description 1
- 229910000029 sodium carbonate Inorganic materials 0.000 description 1
- 235000013599 spices Nutrition 0.000 description 1
- 230000001954 sterilising effect Effects 0.000 description 1
- 210000002784 stomach Anatomy 0.000 description 1
- 230000002195 synergetic effect Effects 0.000 description 1
- 201000008297 typhoid fever Diseases 0.000 description 1
- JLYXXMFPNIAWKQ-UHFFFAOYSA-N γ Benzene hexachloride Chemical compound ClC1C(Cl)C(Cl)C(Cl)C(Cl)C1Cl JLYXXMFPNIAWKQ-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/04—Dispersions; Emulsions
- A61K8/06—Emulsions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/60—Sugars; Derivatives thereof
- A61K8/602—Glycosides, e.g. rutin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/18—Antioxidants, e.g. antiradicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q1/00—Make-up preparations; Body powders; Preparations for removing make-up
- A61Q1/02—Preparations containing skin colorants, e.g. pigments
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/04—Topical preparations for affording protection against sunlight or other radiation; Topical sun tanning preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/10—Washing or bathing preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/52—Stabilizers
- A61K2800/522—Antioxidants; Radical scavengers
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A40/00—Adaptation technologies in agriculture, forestry, livestock or agroalimentary production
- Y02A40/90—Adaptation technologies in agriculture, forestry, livestock or agroalimentary production in food processing or handling, e.g. food conservation
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Abstract
The invention provides an emulsion containing clove fruit extract, which comprises clove fruit extract, glucamate SSE-20, glucate SS, eumulgin SG and a cosmetic matrix. The emulsion containing the clove fruit extract provided by the invention has a better moisturizing effect, provides a relatively long-lasting moisturizing effect for skin, and also has certain whitening and antioxidant effects.
Description
Technical Field
The invention belongs to the technical field of daily chemical articles, and particularly relates to an emulsion containing a clove fruit extract, and a preparation method and application thereof.
Background
The emulsion additive refers to a small amount or trace substance added in the production process and the use process of the emulsion, and the dosage in the emulsion is small but the effect is obvious. The emulsion additive is a raw material frequently used in modern emulsion industry, and has obvious effects on enhancing the efficacy value of basic emulsion and the like.
Eugenia caryophyllata Thunb of Myrtaceae is a spice native to Indonesia, has been introduced to tropical regions around the world, and is one of the traditionally imported "south drugs" in China. Clove as a traditional imported Chinese medicinal material has been widely developed in application value, and has been formulated as stomach medicine, muscle relaxing ointment, nose patch, sleep-aiding powder and the like so far; in the aspect of life application, the plant growth regulator is also involved in hunting, such as lasting essence, mosquito repellent, bacteriostatic hand sanitizer, traditional Chinese medicine distiller's yeast and the like. According to the chemical law of plant resources, different parts of the same plant may contain the same or similar components, and clove as a medicinal plant has the main medicinal value in flower buds, but the development of active ingredients of other parts such as fruits, leaves and rhizomes is also necessary. The clove is originally filed in Lei Gong Pao Zhi Lun, the fruits of the clove are firstly seen in Liang Dai ceramic Hongjing named medical records by taking 'chicken tongue fragrance' as a medicine, the later southern herbal records also record the fruits, the national traditional Chinese medicine administration records the clove fruits as one of 39 Chinese medicinal material varieties which are mainly developed in China, the pharmacological activity of the clove fruits covers many aspects, for example, the clove oil contained in the clove bud has strong antifungal and antifungal activities, and can be used as a natural antifungal agent for storing fruits in winter; the clove decoction has obvious inhibition effect on pathogenic bacteria such as tubercle bacillus, typhoid bacillus, dysentery bacillus and the like, and can treat related diseases caused by the pathogenic bacteria; the ethyl acetate extract contained in the clove fruit has strong acaricidal activity and the like.
Therefore, how to use the clove fruit extract in the emulsion to enable the emulsion to have better moisturizing effect, provide relatively long-lasting moisturizing effect for skin and simultaneously have certain whitening and antioxidant effects is a problem to be solved.
Disclosure of Invention
In view of this, the technical problem to be solved by the present invention is to provide an emulsion containing a clove fruit extract, and a preparation method and an application thereof.
The invention provides an emulsion containing clove fruit extract, which comprises clove fruit extract, glucamate SSE-20, glucate SS, eumulgin SG and a cosmetic matrix.
Preferably, the clove fruit extract is an ethyl acetate extract of clove fruit.
Preferably, the feed additive is prepared from the following raw materials in parts by mass:
1 to 3 portions of Glucamate SSE-20, 0.5 to 1.5 portions of Glucate SS, 0.2 to 0.4 portion of Eumulgin SG, 3 to 5 portions of clove fruit ethyl acetate extract and 81.5 to 106.16 portions of cosmetic matrix.
Preferably, the feed is prepared from the following raw materials in parts by mass:
1 to 3 portions of Glucamate SSE-20, 0.5 to 1.5 portions of Glucate SS, 1 to 3 portions of stearic acid, 2 to 4 portions of ethylhexyl methoxycinnamate, 6 to 8 portions of octyldodecanol, 0.2 to 0.4 portion of Eumulgin SG, 0.04 to 0.06 portion of EDTA disodium, 3 to 5 portions of glycerin, 0.05 to 0.15 portion of xanthan gum, 0.3 to 0.5 portion of hydroxyethyl acrylate, 0.05 to 0.15 portion of citric acid, 0.05 to 0.15 portion of methyl paraben, 3 to 5 portions of clove fruit ethyl acetate extract, 3 to 5 portions of 1,3-butanediol, 3 to 5 portions of beta-glucan, 0.05 to 0.15 portion of pentaerythritol tetra (di-tert-butyl hydroxy hydrocinnamate) and 60 to 70 portions of water.
Preferably, the feed is prepared from the following raw materials in parts by mass:
0.5 to 2.5 portions of Glucamate SSE-20, 0.3 to 1.2 portions of Glucate SS, 0.5 to 2.5 portions of stearic acid, 1.5 to 3.5 portions of ethylhexyl methoxycinnamate, 5.5 to 7.5 portions of octyldodecanol, 0.15 to 0.35 portion of Eumulgin SG, 0.03 to 0.05 portion of EDTA disodium, 2 to 4 portions of glycerol, 0.02 to 0.12 portion of xanthan gum, 0.2 to 0.4 portion of hydroxyethyl acrylate, 0.03 to 0.12 portion of citric acid, 0.03 to 0.12 portion of methylparaben, 2 to 4 portions of clove fruit ethyl acetate extract, 1,3-2 to 4 portions of butanediol, 2 to 4 portions of beta-glucan, 0.03 to 0.13 portion of pentaerythritol tetra (di-tert-butyl hydroxy hydrocinnamate) and 60 to 70 portions of water.
Preferably, the feed additive is prepared from the following raw materials in parts by mass:
glucamate SSE-20 parts, glucate SS 1 part, stearic acid 2 parts, ethylhexyl methoxycinnamate 3 parts, octyldodecanol 7 parts, eumulgin SG 0.3 parts, disodium EDTA 0.05 parts, glycerin 4 parts, xanthan gum 0.1 parts, hydroxyethyl acrylate 0.4 parts, citric acid 0.1 parts, methyl paraben 0.1 parts, clove fruit ethyl acetate extract 4 parts, 1,3-butanediol 4 parts, beta-glucan 4 parts, pentaerythritol tetrakis (di-tert-butyl hydroxy hydrocinnamate) 0.1 parts, and water 67.85 parts.
The invention also provides a preparation method of the emulsion, which comprises the following steps:
a) Mechanically stirring Glucamate SSE-20, glucoate SS, stearic acid, ethylhexyl methoxycinnamate, octyldodecanol and pentaerythritol tetrakis (di-tert-butyl hydroxyhydrocinnamate) ester uniformly until the solid is completely dissolved to obtain an oil phase;
b) Stirring and dissolving water, hydroxyethyl acrylate, eumulgin SG, 1,3-butanediol, beta-glucan, glycerol, methyl paraben and xanthan gum to obtain a water phase;
c) Mixing and emulsifying the oil phase and the water phase to obtain an emulsion;
d) Adding the clove fruit extract and EDTA disodium into the emulsion, mixing, and adjusting the pH value to obtain the emulsion containing the clove fruit extract.
Preferably, the pH is adjusted to 4.0 to 5.0.
The invention also provides an application of the emulsion in preparing cosmetics with moisturizing and oxidation resisting properties.
Preferably, the cosmetic product is selected from a skin cleansing product, lotion, cream, serum, barrier, sunscreen, foundation or concealer.
Compared with the prior art, the invention provides an emulsion containing clove fruit extract, which comprises clove fruit extract, glucamate SSE-20, glucate SS, eumulgin SG and a cosmetic matrix. The two emulsifiers used in the invention are Glucamate SSE-20, glucate SS and Eumulgin SG, wherein the oil-phase emulsifiers Glucamate SSE-20 and Glucate SS are unique nonionic emulsifiers and are one of glucoside derivatives in natural corn starch, the Glucate SS has water-in-oil emulsifying activity, and the glucarate SSE-20 is an oil-in-water emulsifier which is combined to generate high-quality emulsification; moreover, the viscosity generated by Glucate SSE-20 and Glucate SS is resistant to the damaging effects of mechanical work or shear stress applied after emulsion formation, and can generally recover within days if the viscosity drops during production operations due to pumping and filling. In addition, the aqueous phase emulsifier Eumulgin SG is a liquid crystal form amino acid emulsifier, has good compatibility with electrolyte, and is very suitable for various formulas rich in additives and skin care product formulas containing water-soluble sun-screening agents; the skin-care product has excellent emulsifying capacity, achieves the purpose of improving skin feel by adjusting the dosage of grease, wax and polymer, has excellent compatibility with various electrolytes, water-soluble UV-sun-screening agents, inorganic sun-screening agents and organic sun-screening agents, promotes the formation of lamellar liquid crystal phase, and has excellent moisturizing capacity; it is also an emulsifier which is very safe and therefore suitable for use in a variety of different skin care product formulations.
In addition, the clove fruit ethyl acetate extract is added into the clove fruit emulsion, wherein the ethyl acetate extract is obtained by sectional extraction after an ethanol solvent extraction method, the clove fruit emulsion has a strong special fragrance, the main components of the ethyl acetate extract comprise compounds such as flavonoids, polyphenols and polysaccharides, and the like, and the substances have strong effects of moisturizing, sun-blocking, bacteriostasis, antioxidation and the like, can improve the skin care effect of the emulsion, and better improve the moisturizing and antioxidation performance of the emulsion.
Detailed Description
The invention provides an emulsion containing clove fruit extract, which is characterized by comprising clove fruit extract, glucamate SSE-20, glucate SS, eumulgin SG and a cosmetic matrix.
In some embodiments of the invention, the clove fruit extract is clove fruit ethyl acetate extract.
The ethyl acetate extract of the clove fruit is obtained by performing sectional extraction after an ethanol solvent extraction method, has a strong special fragrance, contains compounds such as flavonoids, polyphenols and polysaccharides as main components, has strong effects of moisture retention, sun protection, bacteriostasis, oxidation resistance and the like, can improve the skin care effect of the emulsion, and can well improve the moisture retention and oxidation resistance of the emulsion.
Specifically, the ethyl acetate extract of the clove fruit provided by the invention is prepared according to the following method:
extracting the ethyl acetate extract of the clove fruit by adopting a solvent extraction method:
grinding and pulverizing naturally air dried clove fruit with high speed pulverizer, repeatedly stirring and extracting with high concentration ethanol, concentrating to obtain solid extract of clove fruit,
then dispersing the solid extract of the clove fruit into ultrapure water, adding petroleum ether for extraction, standing for layering, removing a petroleum ether layer, adding dichloromethane for extraction, standing for layering, removing a dichloromethane layer, and finally adding ethyl acetate for extraction to obtain an ethyl acetate layer;
and (3) carrying out rotary evaporation, concentration and evaporation on the ethyl acetate layer, and collecting the obtained ethyl acetate extract of the clove fruit.
Wherein the volume concentration of the high-concentration ethanol is 85-95%;
the mass volume ratio of the naturally air-dried clove fruits to the high-concentration ethanol is 6kg
The mass volume ratio of the clove fruit solid extract to the ultrapure water is 2kg:5L; the volume ratio of the ultrapure water to the petroleum ether to the dichloromethane to the ethyl acetate is 5:3.5:6:6.
in some embodiments of the invention, the clove fruit extract-containing emulsion is prepared from the following raw materials in parts by mass:
1-3 parts of Glucamate SSE-20, 0.5-1.5 parts of glucoate SS, 0.2-0.4 part of Eumulgin SG, 3-5 parts of clove fruit ethyl acetate extract and 81.5-106.16 parts of cosmetic matrix.
The cosmetic matrix is not particularly limited, and can be used as a raw material matrix and an auxiliary material matrix for preparing emulsion.
In some embodiments of the present invention, the clove fruit extract-containing emulsion is prepared from the following raw materials in parts by mass:
1 to 3 portions of Glucamate SSE-20, 0.5 to 1.5 portions of Glucate SS, 1 to 3 portions of stearic acid, 2 to 4 portions of ethylhexyl methoxycinnamate, 6 to 8 portions of octyldodecanol, 0.2 to 0.4 portion of Eumulgin SG, 0.04 to 0.06 portion of EDTA disodium, 3 to 5 portions of glycerin, 0.05 to 0.15 portion of xanthan gum, 0.3 to 0.5 portion of hydroxyethyl acrylate, 0.05 to 0.15 portion of citric acid, 0.05 to 0.15 portion of methyl paraben, 3 to 5 portions of clove fruit ethyl acetate extract, 3 to 5 portions of 1,3-butanediol, 3 to 5 portions of beta-glucan, 0.05 to 0.15 portion of pentaerythritol tetra (di-tert-butyl hydroxy hydrocinnamate) and 60 to 70 portions of water.
In some preferred embodiments, the clove fruit extract-containing emulsion is prepared from the following raw materials in parts by mass:
0.5-2.5 parts of Glucamate SSE-20, 0.3-1.2 parts of Glucate SS, 0.5-2.5 parts of stearic acid, 1.5-3.5 parts of ethylhexyl methoxycinnamate, 5.5-7.5 parts of octyldodecanol, 0.15-0.35 part of Eumulgin SG, 0.03-0.05 part of EDTA disodium, 2-4 parts of glycerol, 0.02-0.12 part of xanthan gum, 0.2-0.4 part of hydroxyethyl acrylate, 0.03-0.12 part of citric acid, 0.03-0.12 part of methylparaben, 2-4 parts of clove fruit ethyl acetate extract, 2-4 parts of 1,3-butanediol, 2-4 parts of beta-glucan, 0.03-0.13 part of pentaerythritol tetra (di-tert-butyl hydroxy hydrocinnamate) and 60-70 parts of water.
In some more preferred embodiments of the present invention, the clove fruit extract containing emulsion is prepared from the following raw materials in parts by mass:
glucamate SSE-20 parts, glucate SS 1 part, stearic acid 2 parts, ethylhexyl methoxycinnamate 3 parts, octyldodecanol 7 parts, eumulgin SG 0.3 parts, disodium EDTA 0.05 parts, glycerin 4 parts, xanthan gum 0.1 parts, hydroxyethyl acrylate 0.4 parts, citric acid 0.1 parts, methyl paraben 0.1 parts, clove fruit ethyl acetate extract 4 parts, 1,3-butanediol 4 parts, beta-glucan 4 parts, pentaerythritol tetrakis (di-tert-butyl hydroxy hydrocinnamate) 0.1 parts, and water 67.85 parts.
The invention also provides a preparation method of the emulsion containing the clove fruit extract, which comprises the following steps:
a) Mechanically stirring Glucamate SSE-20, glucoate SS, stearic acid, ethylhexyl methoxycinnamate, octyldodecanol and pentaerythritol tetrakis (di-tert-butyl hydroxyhydrocinnamate) ester uniformly until the solid is completely dissolved to obtain an oil phase;
b) Stirring and dissolving water, hydroxyethyl acrylate, eumulgin SG, 1,3-butanediol, beta-glucan, glycerol, methyl paraben and xanthan gum to obtain a water phase;
c) Mixing and emulsifying the oil phase and the water phase to obtain an emulsion;
d) Adding the clove fruit extract and EDTA disodium into the emulsion, and adjusting the pH value with citric acid to obtain the emulsion containing the clove fruit extract.
Specifically, a cleaned and dried oil phase pot is prepared and heated, an oil phase emulsifier, stearic acid, ethylhexyl methoxycinnamate, octyldodecanol, pentaerythritol tetrakis (di-tert-butylhydroxyhydrocinnamate) ester are added, and the mixture is mechanically stirred uniformly until the solid is completely dissolved to obtain an oil phase; the heating temperature is 80-90 ℃.
Adding deionized water into a water phase pot, adding hydroxyethyl acrylate, a water phase emulsifier, 1,3-butanediol, glycerol, methyl paraben and xanthan gum, wherein the xanthan gum needs to be added with the glycerol in advance, stirring to dissolve the glycerol, raising the water bath temperature to 80-90 ℃, and mechanically stirring uniformly until the glycerol is completely dissolved to obtain a water phase;
adding the oil phase component which is uniformly dispersed into the water phase, adjusting the temperature of the water bath to 80-90 ℃, and setting the homogenizing speed to 3000-3500 r.min -1 And continuously homogenizing for 5-8 min, stopping heating after the emulsification process is finished, and continuously stirring until the temperature is cooled to the room temperature.
Finally, adding the ethyl acetate extract of the clove fruit and the EDTA disodium, and continuously stirring for 5-8 min to adjust the pH value to obtain the final emulsion product. Adjustment of the pH requires complete cooling to room temperature. Wherein the pH is 4.0-5.0.
The preparation method of the emulsion containing the clove fruit extract provided by the invention is simple in process and convenient to operate.
The invention also provides application of the emulsion containing the clove fruit extract in preparing cosmetics with moisturizing and oxidation resisting properties.
Wherein the cosmetic is selected from the group consisting of a skin cleansing product, lotion, cream, essence, barrier, sunscreen, foundation, and concealer.
According to the invention, the clove fruit extract is added and the emulsifier of a specific type is combined, so that the emulsion has a better moisturizing effect, provides a relatively long-lasting moisturizing effect for skin, and has certain whitening and antioxidant effects.
In order to further understand the present invention, the following examples are provided to illustrate the emulsion containing clove fruit extract and the preparation method and application thereof, and the scope of the present invention is not limited by the following examples.
In the following examples, ethyl acetate extract of clove fruit was prepared as follows:
extracting the ethyl acetate extract of the clove fruit by adopting a solvent extraction method:
taking 6kg of naturally air-dried clove fruit, grinding and crushing by a high-speed crusher, repeatedly stirring and leaching for 7 times for 72 hours by using 15L of ethanol with the volume concentration of 95%, combining leaching liquor, and concentrating to obtain the solid extract of the clove fruit.
Dispersing 2kg of clove fruit solid extract into 5L of ultrapure water, adding 3.5L of petroleum ether for extraction, standing for layering, removing a petroleum ether layer, adding 6L of dichloromethane for extraction, standing for layering, removing a dichloromethane layer, and finally adding 6L of ethyl acetate for extraction to obtain an ethyl acetate layer;
and (3) carrying out rotary evaporation, concentration and evaporation on the ethyl acetate layer, and collecting 124g of the obtained ethyl acetate extract of the clove fruit.
Example 1
Glucamate SSE-20 parts, glucate SS 1 part, stearic acid 2 parts, ethylhexyl methoxycinnamate 3 parts, octyldodecanol 7 parts, eumulgin SG 0.3 parts, disodium EDTA 0.05 parts, glycerin 4 parts, xanthan gum 0.1 parts, hydroxyethyl acrylate 0.4 parts, citric acid 0.1 parts, methyl paraben 0.1 parts, clove fruit ethyl acetate extract 4 parts, 1,3-butanediol 4 parts, beta-glucan 4 parts, pentaerythritol tetrakis (di-tert-butyl hydroxy hydrocinnamate) 0.1 parts, and water 67.85 parts.
The preparation method of the emulsion containing the clove fruit extract comprises the following steps:
heating a cleaned and dried oil phase pot to 85 ℃, adding an oil phase emulsifier, stearic acid, ethylhexyl methoxycinnamate, octyldodecanol and pentaerythritol tetra (di-tert-butyl hydroxy hydrocinnamate), and mechanically stirring uniformly until the solid is completely dissolved; adding deionized water into a water phase pot, adding hydroxyethyl acrylate, a water phase emulsifier, 1,3-butanediol, glycerol, methyl paraben and xanthan gum, wherein the glycerol is required to be added in advance for the xanthan gum to be dissolved by stirring, raising the temperature of a water bath to 85 ℃, and mechanically stirring uniformly until the xanthan gum is completely dissolved; adding the uniformly dispersed oil phase into the water phase, adjusting the water bath temperature to 85 deg.C, and setting the homogenization speed at 3000r min -1 And continuously homogenizing for 5min, stopping heating after the emulsification process is finished, continuously stirring until the mixture is cooled to room temperature, and finally adding the ethyl acetate extract of the clove fruit and the EDTA disodium, continuously stirring for 6min, and adjusting the pH value to obtain the final emulsion product.
Example 2
Glucamate SSE-20 parts, glucate SS 0.5 part, stearic acid 1 part, ethylhexyl methoxycinnamate 2 parts, octyldodecanol 6 parts, eumulgin SG 0.2 part, disodium EDTA 0.04 part, glycerin 3 parts, xanthan gum 0.05 part, hydroxyethyl acrylate 0.3 part, citric acid 0.05 part, methyl paraben 0.05 part, clove fruit ethyl acetate extract 3 parts, 1,3-butanediol 3 parts, beta-glucan 3 parts, pentaerythritol tetrakis (di-tert-butyl hydroxy hydrocinnamate) 0.05 part, and water 76.76 parts.
The preparation method of the emulsion containing the clove fruit extract comprises the following steps:
heating a cleaned and dried oil phase pot to 85 ℃, adding an oil phase emulsifier, stearic acid, ethylhexyl methoxycinnamate, octyldodecanol and pentaerythritol tetra (di-tert-butyl hydroxy hydrocinnamate) ester, and mechanically stirring uniformly until the solid is completely dissolved; adding deionized water into a water phase pot, adding hydroxyethyl acrylate, a water phase emulsifier, 1,3-butanediol, glycerol, methyl paraben and xanthan gum, wherein the glycerol is required to be added in advance for the xanthan gum to be dissolved by stirring, raising the temperature of a water bath to 85 ℃, and mechanically stirring uniformly until the xanthan gum is completely dissolved; adding the uniformly dispersed oil phase into the water phase, adjusting the water bath temperature to 85 deg.C, and setting the homogenization speed at 3000r min -1 And continuously homogenizing for 5min, stopping heating after the emulsification process is finished, continuously stirring until the mixture is cooled to room temperature, and finally adding the ethyl acetate extract of the clove fruit and the EDTA disodium, continuously stirring for 6min, and adjusting the pH value to obtain the final emulsion product.
Example 3
Glucamate SSE-20.5 parts, glucate SS 1 part, stearic acid 1.5 parts, ethylhexyl methoxycinnamate 3.5 parts, octyldodecanol 7.5 parts, eumulgin SG 0.3 parts, disodium EDTA 0.05 parts, glycerol 4 parts, xanthan gum 0.1 parts, hydroxyethyl acrylate 0.4 parts, citric acid 0.1 parts, methyl paraben 0.1 parts, clove fruit ethyl acetate extract 4 parts, 1,3-butanediol 4 parts, beta-glucan 4 parts, pentaerythritol tetrakis (di-tert-butyl hydroxyhydrocinnamate) 0.1 parts, and water 67.85 parts.
The preparation method of the emulsion containing the clove fruit extract comprises the following steps:
heating a cleaned and dried oil phase pot to 85 ℃, adding an oil phase emulsifier, stearic acid, ethylhexyl methoxycinnamate, octyldodecanol and pentaerythritol tetra (di-tert-butyl hydroxy hydrocinnamate), and mechanically stirring uniformly until the solid is completely dissolved; adding deionized water into a water phase pot, adding hydroxyethyl acrylate, a water phase emulsifier, 1,3-butanediol, glycerol, methyl paraben and xanthan gum, wherein the glycerol is required to be added in advance for the xanthan gum to be dissolved by stirring, raising the temperature of a water bath to 85 ℃, and mechanically stirring uniformly until the xanthan gum is completely dissolved; will disperse evenlyAdding the oil phase into the water phase, adjusting the temperature of the water bath to 85 deg.C, and setting the homogenization speed at 3000r min -1 And continuously homogenizing for 5min, stopping heating after the emulsification process is finished, continuously stirring until the mixture is cooled to room temperature, and finally adding the ethyl acetate extract of the clove fruit and the EDTA disodium, continuously stirring for 6min, and adjusting the pH value to obtain the final emulsion product.
The ethyl acetate extract of the clove fruit prepared by the invention is subjected to effective chemical component determination:
(1) Material
Gallic acid, forlin phenol, sodium carbonate, absolute ethyl alcohol, anthrone and glucose.
(2) Design of experiments
The test is carried out by referring to T/AHFIA005-2018, namely determination of total polyphenol content in plant extracts and products thereof and GB/T15672-2009, namely determination of total sugar content in edible fungi.
(3) Test results
The linear formula of the measurement results is as follows:
total polyphenols: y =0.0091X +0.0105 2 ＝0.9996；
Total polysaccharide: y =0.007X +0.0673 2 ＝0.9991；
TABLE 1 measurement results of effective chemical components
The results of measuring the content of the effective chemical components of the ethyl acetate extract of the clove fruit are shown in table 1. As shown in Table 1, the total polyphenol and total polysaccharide content of the extract is high, and the ratio is 69.62%. The substances have strong effects of moisturizing, sun-screening, bacteriostasis, antioxidation and the like, can improve the skin care effect of the emulsion, and better improve the moisturizing and antioxidation performance of the emulsion.
In-vitro moisturizing efficacy determination of different moisturizing combinations:
(1) Material
Glycerol; 1,3-butanediol; beta-glucan; water; ethyl acetate extract of clove fruit.
(2) Design of experiments
Accurately weighing the samples according to the following three combinations, placing the samples in a dry culture dish, transferring the samples into a constant-temperature biochemical incubator at 27 ℃, weighing every 1 hour, recording the mass change, and finally calculating the moisture retention rate by using a moisture retention rate formula.
Combination A:4.8g ethyl acetate extract of Syzygium aromaticum fruit +4.8g water
And (B): 1.2g of glycerol +1.2g of 1, 3-butanediol +1.2g of beta-glucan +1.2g of ethyl acetate extract of clove fruit +4.8g of water
And (3) combination C:1.6g of glycerol +1.6g of 1, 3-butanediol +1.6g of beta-glucan +4.8g of water
Wherein: m is a group of 0 The mass (g) of the initial sample to be measured and the drying dish, M 1 The mass (g) of the sample to be tested + the drying dish after n hours.
(3) Test results
Table 2 three combination in vitro moisturizing efficacy assays
A moisturizing test result of an emulsion of clove fruit is shown in Table 2, and the moisturizing abilities of three combinations of 4.8g of ethyl acetate extract of clove fruit +4.8g of water, 1.2g of glycerin +1.2g of 1, 3-butanediol +1.2g of beta-glucan +1.2g of ethyl acetate segment extract of clove fruit +4.8g of water, 1.6g of glycerin +1.6g of 1, 3-butanediol +1.6g of beta-glucan +4.8g of water are measured under the condition of keeping a constant temperature of 27 ℃, and are measured once every 1h and continuously measured for 10h and recorded. It can be seen that within 0-4h, the moisturizing rate of the combination C is slightly higher than that of the combination A and the combination B, and after 5h, the moisturizing capability of the combination C is rapidly reduced and is lower than that of the combination A and the combination B; the moisturizing performances of the combination A and the combination B tend to be consistent after 9 hours, but the moisturizing capability of the combination B is higher than that of the combination A before, so the result shows that the moisturizing combination added with the clove fruit ethyl acetate extract has a lasting moisturizing effect, and the moisturizing combination has a better effect when being mixed with moisturizing agents such as glycerin, 1,3-butanediol, beta-glucan and the like and has a certain synergistic effect.
Moisture retention effect test:
(1) Material
The mice used in the test were provided by Yu's Biotech, haikou; emulsion to be tested: example 1 is a test group with a matrix emulsion without added clove fruit extract as a positive control and without emulsion as a blank control; environmental conditions are as follows: ambient temperature 20-27 ℃, relative humidity: 50% -70%, guinea pig cage: a non-toxic plastic cage; padding: sterilizing the log bedding.
(2) Design of experiments
Preparing 9 male white guinea pigs (about 250 g), cutting hair on the backs of the guinea pigs by using a depilator, deeply depilating before the formal test, the depilating area is about 2x 6cm, lightly wiping the depilated part by using a water-containing cotton yarn, applying 1g of clove fruit emulsion, 1g of emulsion matrix and a blank control from left to right in sequence after 30min, respectively measuring the water content of the depilated area of the 9 guinea pigs by using a moisture tester, and measuring and recording the data once every 1 h.
(3) Test results
TABLE 3 determination of the moisturizing Properties of the emulsions
The moisturizing test results of a clove fruit emulsion are shown in table 3. The water content of the skin of the guinea pigs in the test group and the matrix group is remarkably improved after the skin is applied, the water content of the skin in the test group reaches the highest value within 1 hour after the skin is applied, and the water content is 33.56 +/-0.62%, so that the clove fruit emulsion has a good skin moisturizing effect; after 1h, the water content of the skin of the guinea pigs in the test group and the matrix group is reduced, but a certain water replenishing and moisturizing effect is still achieved compared with that of a blank control group, and the water content of the skin of the guinea pigs in the test group is slightly higher than that of the matrix group; after the lotion is applied for 5 hours, the water content of the skin water of the three groups is almost kept equal, and the water content is approximately recovered to the original level, so that the clove fruit formula lotion has certain water replenishing and moisturizing effects.
The foregoing is only a preferred embodiment of the present invention, and it should be noted that, for those skilled in the art, various modifications and decorations can be made without departing from the principle of the present invention, and these modifications and decorations should also be regarded as the protection scope of the present invention.
Claims (10)
1. An emulsion containing clove fruit extract, comprising clove fruit extract, glucamate SSE-20, glucate SS, eumulgin SG and a cosmetic base.
2. The emulsion of claim 1, wherein the clove fruit extract is clove fruit ethyl acetate extract.
3. The emulsion according to claim 1, which is prepared from the following raw materials in parts by mass:
1-3 parts of Glucamate SSE-20, 0.5-1.5 parts of glucoate SS, 0.2-0.4 part of Eumulgin SG, 3-5 parts of clove fruit ethyl acetate extract and 81.5-106.16 parts of cosmetic matrix.
4. The emulsion according to claim 1, which is prepared from the following raw materials in parts by mass:
1 to 3 portions of Glucamate SSE-20, 0.5 to 1.5 portions of Glucate SS, 1 to 3 portions of stearic acid, 2 to 4 portions of ethylhexyl methoxycinnamate, 6 to 8 portions of octyldodecanol, 0.2 to 0.4 portion of Eumulgin SG, 0.04 to 0.06 portion of EDTA disodium, 3 to 5 portions of glycerin, 0.05 to 0.15 portion of xanthan gum, 0.3 to 0.5 portion of hydroxyethyl acrylate, 0.05 to 0.15 portion of citric acid, 0.05 to 0.15 portion of methyl paraben, 3 to 5 portions of clove fruit ethyl acetate extract, 3 to 5 portions of 1,3-butanediol, 3 to 5 portions of beta-glucan, 0.05 to 0.15 portion of pentaerythritol tetra (di-tert-butyl hydroxy hydrocinnamate) and 60 to 70 portions of water.
5. The emulsion according to claim 1, which is prepared from the following raw materials in parts by mass:
0.5 to 2.5 portions of Glucamate SSE-20, 0.3 to 1.2 portions of Glucate SS, 0.5 to 2.5 portions of stearic acid, 1.5 to 3.5 portions of ethylhexyl methoxycinnamate, 5.5 to 7.5 portions of octyldodecanol, 0.15 to 0.35 portion of Eumulgin SG, 0.03 to 0.05 portion of EDTA disodium, 2 to 4 portions of glycerol, 0.02 to 0.12 portion of xanthan gum, 0.2 to 0.4 portion of hydroxyethyl acrylate, 0.03 to 0.12 portion of citric acid, 0.03 to 0.12 portion of methylparaben, 2 to 4 portions of clove fruit ethyl acetate extract, 1,3-2 to 4 portions of butanediol, 2 to 4 portions of beta-glucan, 0.03 to 0.13 portion of pentaerythritol tetra (di-tert-butyl hydroxy hydrocinnamate) and 60 to 70 portions of water.
6. The emulsion according to claim 1, which is prepared from the following raw materials in parts by mass:
glucamate SSE-20 parts, glucate SS 1 part, stearic acid 2 parts, ethylhexyl methoxycinnamate 3 parts, octyldodecanol 7 parts, eumulgin SG 0.3 parts, disodium EDTA 0.05 parts, glycerin 4 parts, xanthan gum 0.1 parts, hydroxyethyl acrylate 0.4 parts, citric acid 0.1 parts, methyl paraben 0.1 parts, clove fruit ethyl acetate extract 4 parts, 1,3-butanediol 4 parts, beta-glucan 4 parts, pentaerythritol tetrakis (di-tert-butyl hydroxy hydrocinnamate) 0.1 parts, and water 67.85 parts.
7. A process for the preparation of an emulsion according to any one of claims 1 to 6, characterized in that it comprises the following steps:
a) Mechanically stirring Glucamate SSE-20, glucoate SS, stearic acid, ethylhexyl methoxycinnamate, octyldodecanol and pentaerythritol tetrakis (di-tert-butyl hydroxyhydrocinnamate) ester uniformly until the solid is completely dissolved to obtain an oil phase;
b) Stirring and dissolving water, hydroxyethyl acrylate, eumulgin SG, 1,3-butanediol, beta-glucan, glycerol, methyl paraben and xanthan gum to obtain a water phase;
c) Mixing and emulsifying the oil phase and the water phase to obtain an emulsion;
d) Adding the clove fruit extract and EDTA disodium into the emulsion, mixing, and adjusting the pH value to obtain the emulsion containing the clove fruit extract.
8. The method according to claim 7, wherein the pH is adjusted to 4.0 to 5.0.
9. Use of an emulsion according to any one of claims 1 to 6 for the preparation of a cosmetic product having moisturising and antioxidant properties.
10. Use according to claim 9, characterized in that the cosmetic product is chosen from a skin cleansing product, a lotion, a cream, a serum, a barrier, a sun protection, a foundation or a concealer.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202211178490.5A CN115487113B (en) | 2022-09-26 | 2022-09-26 | Emulsion containing clove fruit extract and preparation method and application thereof |
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| CN202211178490.5A CN115487113B (en) | 2022-09-26 | 2022-09-26 | Emulsion containing clove fruit extract and preparation method and application thereof |
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| CN115487113B CN115487113B (en) | 2024-01-16 |
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Citations (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20050008732A1 (en) * | 2003-07-11 | 2005-01-13 | Petros Gebreselassie | Chewing gum and confectionery compositions containing a stain removing complex, and methods of making and using the same |
| US20090169652A1 (en) * | 2007-11-29 | 2009-07-02 | Rosemarie Osborne | Personal Care Compositions |
| CN103393758A (en) * | 2013-07-20 | 2013-11-20 | 石强 | Natural pharmaceutical composition |
| CN104382799A (en) * | 2014-12-01 | 2015-03-04 | 上海汀澜生物科技有限公司 | Skin care product having anti-wrinkle firming and beauty-maintaining moisturizing effects |
| KR20150052907A (en) * | 2013-11-06 | 2015-05-15 | 주식회사 코리아나화장품 | Cosmetic composition for Improving Skin Moisturization Comprising the mixed extract of Peach blossom, Sophora japonica flower, Rhubarb and Clove buds as active ingredient |
| CN105769674A (en) * | 2016-04-05 | 2016-07-20 | 杭州曼迪生物科技有限公司 | Nymphaea tetragona skin moistening and nourishing emulsion and preparation method thereof |
| CN107753333A (en) * | 2017-10-26 | 2018-03-06 | 广州市禾基生物科技有限公司 | Elite dew that a kind of moisturizing is releived and preparation method thereof |
| CN107854337A (en) * | 2017-11-24 | 2018-03-30 | 施维忠 | High whitening emulsion of a kind of stability and preparation method thereof |
| KR20180068914A (en) * | 2018-06-08 | 2018-06-22 | (주)아모레퍼시픽 | Composition for inhibition of aging comprising syringaresinol |
| CN109674702A (en) * | 2019-01-25 | 2019-04-26 | 华东理工大学 | Cloves Compositional type natural antiseptic agent and preparation method and the application in cosmetics |
| CN110721141A (en) * | 2019-11-29 | 2020-01-24 | 张启田 | Whitening and moisturizing face cream |
-
2022
- 2022-09-26 CN CN202211178490.5A patent/CN115487113B/en active Active
Patent Citations (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20050008732A1 (en) * | 2003-07-11 | 2005-01-13 | Petros Gebreselassie | Chewing gum and confectionery compositions containing a stain removing complex, and methods of making and using the same |
| US20090169652A1 (en) * | 2007-11-29 | 2009-07-02 | Rosemarie Osborne | Personal Care Compositions |
| CN103393758A (en) * | 2013-07-20 | 2013-11-20 | 石强 | Natural pharmaceutical composition |
| KR20150052907A (en) * | 2013-11-06 | 2015-05-15 | 주식회사 코리아나화장품 | Cosmetic composition for Improving Skin Moisturization Comprising the mixed extract of Peach blossom, Sophora japonica flower, Rhubarb and Clove buds as active ingredient |
| CN104382799A (en) * | 2014-12-01 | 2015-03-04 | 上海汀澜生物科技有限公司 | Skin care product having anti-wrinkle firming and beauty-maintaining moisturizing effects |
| CN105769674A (en) * | 2016-04-05 | 2016-07-20 | 杭州曼迪生物科技有限公司 | Nymphaea tetragona skin moistening and nourishing emulsion and preparation method thereof |
| CN107753333A (en) * | 2017-10-26 | 2018-03-06 | 广州市禾基生物科技有限公司 | Elite dew that a kind of moisturizing is releived and preparation method thereof |
| CN107854337A (en) * | 2017-11-24 | 2018-03-30 | 施维忠 | High whitening emulsion of a kind of stability and preparation method thereof |
| KR20180068914A (en) * | 2018-06-08 | 2018-06-22 | (주)아모레퍼시픽 | Composition for inhibition of aging comprising syringaresinol |
| CN109674702A (en) * | 2019-01-25 | 2019-04-26 | 华东理工大学 | Cloves Compositional type natural antiseptic agent and preparation method and the application in cosmetics |
| CN110721141A (en) * | 2019-11-29 | 2020-01-24 | 张启田 | Whitening and moisturizing face cream |
Non-Patent Citations (2)
| Title |
|---|
| 刘积光: "药食同源植物丁香的综合利用价值研究", 《中国优秀硕士学位论文全文数据库 农业科技辑》, pages 17 - 18 * |
| 高璐 等: "高速逆流色谱法分离制备母丁香和公丁香中的5种非挥发性化合物", 《色谱》, pages 1112 - 1117 * |
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