Elite dew that a kind of moisturizing is releived and preparation method thereof
Technical field
The invention belongs to cosmetic technical field, and in particular to elite dew that a kind of moisturizing is releived and preparation method thereof.
Background technology
The skin of people divides epidermis, corium and subcutaneous fat.The outermost layer of epidermis is cuticula, due to cuticula in itself
Contained NMF is the work of amino acids, lactate and carbohydrate etc. in water suction, barrier function, and cuticula
With making cuticula keep certain water content, maintain the moistening of skin.And the outward appearance of skin and the moisture of cuticula have
Close, normal keratoderma usually contains 10%-30% moisture, to maintain the soft and elastic of skin.But with the age
Growth, keratoderma moisture can gradually decrease, and when the moisture of keratoderma is less than 10%, and skin is just
Dry, tight, coarse and furfur etc. occurs.In general, the unbalanced internal and external condition of skin natural moisture preserving structure is caused
Mainly have:1st, as the increasing at age, skin aging, its moisture-keeping function and barrier function gradually weaken, NMF content
Reduce.2nd, cold weather is dried, humidity is relatively low, such as autumn and winter.3rd, some cutaneous lesions, such as psoriasis, ichthyosis 4, ring
The organic solvent such as border and chemical factor, such as washing powder, soap, liquid detergent detergent and wine, and prolonged air conditioner surroundings
Deng.5th, diet sleep habit, such as partial eclipse, drink water less, insomnia.Above-mentioned various reasons cause the skin of people to occur water shortage for a long time
Symptom, and then cause more skin problems, such as long spot, small pox, wrinkle, relaxation, therefore be most basic to skin moisture-keeping
Skin care step.
In summary, research and develop it is a kind of with moisturizing releive effect cosmetics it is significant.
The content of the invention
For these reasons, applicant has found a kind of new cosmetics, contained in the cosmetics containing height by studying for many years
The purslane extract of amount, so as to ensure that cosmetics have the moisturizing effect of releiving after being combined with other compositions, research shows, this hair
Bright cosmetics have good stability, have good moisture-keeping function for Skin Cell.
What the present invention was achieved through the following technical solutions.
A kind of moisturizing releive elite dew, the elite dew is prepared by following raw materials:Purslane extract, dried tremella extract
And glycine betaine.
Elite dew is prepared by following raw materials:Purslane extract 15-20 parts by weight, the weight of dried tremella extract 0.001
Measure part, glycine betaine 0.4-0.6 parts by weight.
Elite dew is prepared by following raw materials:Purslane extract, dried tremella extract, glycine betaine, hydroxy ethyl fiber
Plain, polyacrylic acid grafted starch, EDTA- disodiums, tocopherol, trehalose, Sodium Hyaluronate, dipotassium glycyrrhizinate, beta glucan,
Silver.
Elite dew is prepared by following raw materials:Water, hydroxyethyl cellulose, polyacrylic acid grafted starch, glycerine, 1,3-
Butanediol, glycine betaine, isoprene, 1,2- hexylene glycols, EDTA- disodiums, Cremophor RH40, olive oil PEG-7 esters,
Tocopherol, octyl dodecanol, dried tremella extract, purslane extract, trehalose, Sodium Hyaluronate, dipotassium glycyrrhizinate, β-Portugal gather
Sugar, silver.
Elite dew is prepared by following raw materials:Water 65-70 parts by weight, hydroxyethyl cellulose 0.2-0.4 parts by weight, gather
Acrylic acid grafted starch 0.10-0.20 parts by weight, glycerine 2-4 parts by weight, 1,3-BDO 5-8 parts by weight, glycine betaine 0.4-0.6
Parts by weight, isoprene 1.5-2.5 parts by weight, 1,2- hexylene glycol 0.4-0.6 parts by weight, EDTA- disodium 0.04-0.06 weight
Part, Cremophor RH40 0.25-0.35 parts by weight, olive oil PEG-7 esters 0.25-0.35 parts by weight, tocopherol 0.08-
0.12 parts by weight, octyl dodecanol 0.08-0.12 parts by weight, the parts by weight of dried tremella extract 0.001, purslane extract 15-20
Parts by weight, trehalose 0.08-0.12 parts by weight, Sodium Hyaluronate 0.004-0.006 parts by weight, dipotassium glycyrrhizinate 0.04-0.06
Parts by weight, beta glucan 0.05-0.15 parts by weight, silver-colored 0.1-0.3 parts by weight.
The elite dew preparation method be:
Water intaking, glycerine, isoprene, 1,3-BDO, glycine betaine, 1,2- hexylene glycols, hydroxyethyl cellulose, polyacrylic acid
Graft starch, EDETATE SODIUM, trehalose, aqueous phase pot is added, after being heated to 80-85 DEG C, is stirred, be pumped into agitated kettle;
Start is uniformly mixed, 30 minutes, 1000rpm/ points, is stopped stirring, is cooled to 40 DEG C;Add PEG-40 hydrogenations
Castor oil, olive oil PEG-7 esters, tocopherol, octyl dodecanol, dried tremella extract, purslane extract, Sodium Hyaluronate,
Dipotassium glycyrrhizinate, beta glucan, silver, continue to stir, be cooled to room temperature, produce elite dew.
A kind of described moisturizing releive elite dew, the application in the cosmetics releived in skin moisture-keeping, skin.
Raw material of the present invention is purchased from and is shown in Table 1:
1 raw material sources of the present invention of table
Raw material |
Purchased from producer |
Date of manufacture |
Hydroxyethyl cellulose |
U.S. Ya Shilan |
2016.04.03 |
Polyacrylic acid grafted starch |
Daito Kasei Kogyo |
2015.12.06 |
Glycerine |
Cocoanut tree Acidchem |
2016.08.09 |
1,3-BDO |
Japan DAICEL |
2017.01.08 |
Glycine betaine |
Asahi Chemical Industry Asahi Kasel |
2016.04.03 |
Isoprene |
Japan Kuraray |
2016.05.10 |
1,2- hexylene glycol |
Symrise |
2016.02.18 |
EDTA- disodiums |
Aksu AKZO NOBEL |
2016.01.19 |
Cremophor RH40 |
German BASF |
2016.11.23 |
Olive oil PEG-7 esters |
Taiwan CORUM |
2015.12.24 |
Tocopherol |
Zhejiang YIYAO |
2017.03.05 |
Purslane extract |
Guangzhou standing grain base |
2016.09.08 |
Trehalose |
Japanese woods is former |
2016.05.04 |
Sodium Hyaluronate |
The prosperous Fu Ruida of China |
2017.02.23 |
Dipotassium glycyrrhizinate |
Gansu Qinghai Lake medicine company |
2016.10.21 |
Beta glucan |
Korea Macrocare Tech |
2015.11.29 |
Silver |
The Japan longevity chambers of commerce |
2017.05.08 |
Specific embodiment
Technical scheme, but protection scope of the present invention not limited to this are illustrated with specific embodiment below.
Content described in this specification embodiment is only enumerating to the way of realization of inventive concept, protection of the invention
Scope is not construed as being only limitted to the concrete form that embodiment is stated, protection scope of the present invention is also and in art technology
Personnel according to present inventive concept it is conceivable that equivalent technologies mean.Although embodiment of the invention below is retouched
State, but the invention is not limited in above-mentioned specific embodiments and applications field, following specific embodiments are only to show
It is meaning property, guiding rather than restricted.One of ordinary skill in the art is under the enlightenment of this specification and is not taking off
In the case of the scope protected from the claims in the present invention, the form of many kinds can also be made, these belong to the present invention
The row of protection.
The following experiments of the present invention, it is on the basis of multiple creative experiment, with the claimed technical scheme of the present invention
Based on, the conclusive experiment of the research staff of summary.
Experiment 1
Moisturizing experimental study
Test 1 group:Water 67mg, hydroxyethyl cellulose 0.3mg, polyacrylic acid grafted starch 0.15mg, glycerine 3mg, 1,3-
Butanediol 6.5mg, glycine betaine 0.5mg, isoprene 2.0mg, 1,2- hexylene glycol 0.5mg, EDTA- disodiums 0.05mg, PEG-40
Rilanit special 0.30mg, olive oil PEG-7 esters 0.30mg, tocopherol 0.10mg, octyl dodecanol 0.10mg, white fungus extraction
Thing 0.001mg, purslane extract 17.5mg, trehalose 0.10mg, Sodium Hyaluronate 0.005mg, dipotassium glycyrrhizinate 0.05mg,
Beta glucan 0.30mg, silver-colored 0.20mg.
The elite dew preparation method be:
Water intaking, glycerine, isoprene, 1,3-BDO, glycine betaine, 1,2- hexylene glycols, hydroxyethyl cellulose, polyacrylic acid
Graft starch, EDETATE SODIUM, trehalose, aqueous phase pot is added, after being heated to 80-85 DEG C, is stirred, be pumped into agitated kettle;
Start is uniformly mixed, 30 minutes, 1000rpm/ points, is stopped stirring, is cooled to 40 DEG C;Add PEG-40 hydrogenations
Castor oil, olive oil PEG-7 esters, tocopherol, octyl dodecanol, dried tremella extract, purslane extract, Sodium Hyaluronate,
Dipotassium glycyrrhizinate, beta glucan, silver, continue to stir, be cooled to room temperature, produce elite dew.
Test 2 groups:Water 67mg, hydroxyethyl cellulose 0.3mg, polyacrylic acid grafted starch 0.15mg, glycerine 3mg, 1,3-
Butanediol 6.5mg, glycine betaine 0.5mg, isoprene 2.0mg, 1,2- hexylene glycol 0.5mg, EDTA- disodiums 0.05mg, PEG-40
Rilanit special 0.30mg, olive oil PEG-7 esters 0.30mg, tocopherol 0.10mg, octyl dodecanol 0.10mg, white fungus extraction
Thing 0.001mg, purslane extract 0.005mg, trehalose 0.10mg, Sodium Hyaluronate 17.5mg, dipotassium glycyrrhizinate 0.05mg,
Beta glucan 0.30mg, silver-colored 0.20mg.
The elite dew preparation method be:
Water intaking, glycerine, isoprene, 1,3-BDO, glycine betaine, 1,2- hexylene glycols, hydroxyethyl cellulose, polyacrylic acid
Graft starch, EDETATE SODIUM, trehalose, aqueous phase pot is added, after being heated to 80-85 DEG C, is stirred, be pumped into agitated kettle;
Start is uniformly mixed, 30 minutes, 1000rpm/ points, is stopped stirring, is cooled to 40 DEG C;Add PEG-40 hydrogenations
Castor oil, olive oil PEG-7 esters, tocopherol, octyl dodecanol, dried tremella extract, purslane extract, Sodium Hyaluronate,
Dipotassium glycyrrhizinate, beta glucan, silver, continue to stir, be cooled to room temperature, produce elite dew.
Test method:Sodium Hyaluronate (cosmetics-stage);Ammonium sulfate and discoloration silica gel;MTT;Cell culture medium:Contain
The MEM culture mediums of 10% calf serum (PAA), 100U/ml penicillin and 100U/ml streptomysins;0.25% pancreatin;Cell people's table
Cornu cutaneum cell plastid strain HaCat;
When epidermal growth to fusion rate is up to more than 80%, adds the MEM culture mediums without calf serum and make synchronously
Change processing 12h, collected by trypsinisation, cell concentration is adjusted after counting, be seeded to 24 well culture plates.After cell attachment, add
μ g/ml of test group cosmetics 1000 prepared is diluted with culture medium in advance, is incubated, positive control is Sodium Hyaluronate
(1000μg/ml).After 24h, it is placed in super-clean bench under certain wind speed after processing is dried, adds fresh culture, continue to train
24h is supported, carries out MTT measure.In experiment blank control group is used as using without any processing group.Cell is calculated as follows to dry
The death rate (%) and protection ratio (%).
Cell dries the death rate (%)=(1- detection group OD values/normal group OD values) × 100%
Protection ratio (%)=(blank group cell dries the death rate-test group cell and dries the death rate)/blank group cell is done
The dry death rate × 100%
Result of the test:It is shown in Table 1.
The each group epidermal cell of table 1 dries the comparison of the death rate and protection ratio
Note:The * * P compared with blank group<0.01, * P<0.05.
Conclusion (of pressure testing):It was found from to epidermal cell dry-run protection experimental study, positive controls show preferably thin
Born of the same parents' protective effect, and test group of the present invention also has good cytoprotection, purslane extract is substituted for equal
Sodium Hyaluronate (2 groups of experiment), declines to cytoprotection, further proves, elite dew of the present invention can significantly be resisted dry
The dry damage to epidermal cell, the influence dried to cell viability is reduced, there is good moisture-keeping function.
Experiment 2
Heat resistant test
Test 1 group:Water 67mg, hydroxyethyl cellulose 0.3mg, polyacrylic acid grafted starch 0.15mg, glycerine 3mg, 1,3-
Butanediol 6.5mg, glycine betaine 0.5mg, isoprene 2.0mg, 1,2- hexylene glycol 0.5mg, EDTA- disodiums 0.05mg, PEG-40
Rilanit special 0.30mg, olive oil PEG-7 esters 0.30mg, tocopherol 0.10mg, octyl dodecanol 0.10mg, white fungus extraction
Thing 0.001mg, purslane extract 17.5mg, trehalose 0.10mg, Sodium Hyaluronate 0.005mg, dipotassium glycyrrhizinate 0.05mg,
Beta glucan 0.30mg, silver-colored 0.20mg.
The elite dew preparation method be:
Water intaking, glycerine, isoprene, 1,3-BDO, glycine betaine, 1,2- hexylene glycols, hydroxyethyl cellulose, polyacrylic acid
Graft starch, EDETATE SODIUM, trehalose, aqueous phase pot is added, after being heated to 80-85 DEG C, is stirred, be pumped into agitated kettle;
Start is uniformly mixed, 30 minutes, 1000rpm/ points, is stopped stirring, is cooled to 40 DEG C;Add PEG-40 hydrogenations
Castor oil, olive oil PEG-7 esters, tocopherol, octyl dodecanol, dried tremella extract, purslane extract, Sodium Hyaluronate,
Dipotassium glycyrrhizinate, beta glucan, silver, continue to stir, be cooled to room temperature, produce elite dew.
Test 2 groups:Water 67mg, hydroxyethyl cellulose 0.3mg, glycerine 3mg, 1,3-BDO 6.5mg, glycine betaine 0.5mg,
Isoprene 2.0mg, 1,2- hexylene glycol 0.5mg, EDTA- disodiums 0.05mg, Cremophor RH40 0.30mg, olive oil
PEG-7 esters 0.30mg, tocopherol 0.10mg, octyl dodecanol 0.10mg, dried tremella extract 0.001mg, purslane extract
17.5mg, trehalose 0.10mg, Sodium Hyaluronate 0.005mg, dipotassium glycyrrhizinate 0.05mg, beta glucan 0.30mg, silver
0.20mg。
The elite dew preparation method be:
Water intaking, glycerine, isoprene, 1,3-BDO, glycine betaine, 1,2- hexylene glycols, hydroxyethyl cellulose, EDTA bis-
Sodium, trehalose, aqueous phase pot is added, after being heated to 80-85 DEG C, is stirred, be pumped into agitated kettle;
Start is uniformly mixed, 30 minutes, 1000rpm/ points, is stopped stirring, is cooled to 40 DEG C;Add PEG-40 hydrogenations
Castor oil, olive oil PEG-7 esters, tocopherol, octyl dodecanol, dried tremella extract, purslane extract, Sodium Hyaluronate,
Dipotassium glycyrrhizinate, beta glucan, silver, continue to stir, be cooled to room temperature, produce elite dew.Test method:By different elite
Dew adds the plastic drug package of 2 bottles of clean dries, tightens lid, and one bottle is put into the constant temperature for being pre-adjusted that temperature is 48 ± 1 DEG C
In case, taken out after 48 hours, range estimation comparison is carried out with another bottle after recovery room temperature.
Result of the test:It is shown in Table 3.
The heat resistant test result of table 3
Group |
Whether there is water-oil separating before experiment |
Whether there is water-oil separating after experiment |
Test 1 group |
It is no |
It is no |
Test 2 groups |
It is no |
It is |
Conclusion (of pressure testing):Heat resistant test shows that after adding polyacrylic acid grafted starch in elite dew of the present invention, elite dew has
More preferable stability.
Prepare embodiment
Embodiment 1
Elite reveals raw material:Water 65g, hydroxyethyl cellulose 0.2g, polyacrylic acid grafted starch 0.10g, glycerine 2g, 1,3-
Butanediol 5g, glycine betaine 0.4g, isoprene 1.5g, 1,2- hexylene glycol 0.4g, EDTA- disodium 0.04g, PEG-40 hydrogenated castors
Oily 0.25g, olive oil PEG-7 esters 0.25g, tocopherol 0.08g, octyl dodecanol 0.08g, dried tremella extract 0.001g, horse
Sativa extract 15g, trehalose 0.08g, Sodium Hyaluronate 0.004g, dipotassium glycyrrhizinate 0.04g, beta glucan 0.30g, silver
0.20g。
The elite dew preparation method be:
Water intaking, glycerine, isoprene, 1,3-BDO, glycine betaine, 1,2- hexylene glycols, hydroxyethyl cellulose, polyacrylic acid
Graft starch, EDETATE SODIUM, trehalose, aqueous phase pot is added, after being heated to 80-85 DEG C, is stirred, be pumped into agitated kettle;
Start is uniformly mixed, 30 minutes, 1000rpm/ points, is stopped stirring, is cooled to 40 DEG C;Add PEG-40 hydrogenations
Castor oil, olive oil PEG-7 esters, tocopherol, octyl dodecanol, dried tremella extract, purslane extract, Sodium Hyaluronate,
Dipotassium glycyrrhizinate, beta glucan, silver, continue to stir, be cooled to room temperature, produce elite dew.
Embodiment 2
Elite reveals raw material:Water 70g, hydroxyethyl cellulose 0.4g, polyacrylic acid grafted starch 0.20g, glycerine 4g, 1,3-
Butanediol 8g, glycine betaine 0.6g, isoprene 2.5g, 1,2- hexylene glycol 0.6g, EDTA- disodium 0.06g, PEG-40 hydrogenated castors
Oily 0.35g, olive oil PEG-7 esters 0.35g, tocopherol 0.12g, octyl dodecanol 0.12g, dried tremella extract 0.001g, horse
Sativa extract 20g, trehalose 0.12g, Sodium Hyaluronate 0.006g, dipotassium glycyrrhizinate 0.06g, beta glucan 0.30g, silver
0.20g。
The elite dew preparation method be:
Water intaking, glycerine, isoprene, 1,3-BDO, glycine betaine, 1,2- hexylene glycols, hydroxyethyl cellulose, polyacrylic acid
Graft starch, EDETATE SODIUM, trehalose, aqueous phase pot is added, after being heated to 80-85 DEG C, is stirred, be pumped into agitated kettle;
Start is uniformly mixed, 30 minutes, 1000rpm/ points, is stopped stirring, is cooled to 40 DEG C;Add PEG-40 hydrogenations
Castor oil, olive oil PEG-7 esters, tocopherol, octyl dodecanol, dried tremella extract, purslane extract, Sodium Hyaluronate,
Dipotassium glycyrrhizinate, beta glucan, silver, continue to stir, be cooled to room temperature, produce elite dew.
Embodiment 3
Elite reveals raw material:Water 66g, hydroxyethyl cellulose 0.25g, polyacrylic acid grafted starch 0.12g, glycerine 2.5g,
1,3-BDO 5.5g, glycine betaine 0.45g, isoprene 1.6g, 1,2- hexylene glycol 0.45g, EDTA- disodiums 0.05g, PEG-40
Rilanit special 0.28g, olive oil PEG-7 esters 0.28g, tocopherol 0.09g, octyl dodecanol 0.09g, dried tremella extract
0.001g, purslane extract 18g, trehalose 0.09g, Sodium Hyaluronate 0.005g, dipotassium glycyrrhizinate 0.045g, beta glucan
0.30g, silver-colored 0.20g.
The elite dew preparation method be:
Water intaking, glycerine, isoprene, 1,3-BDO, glycine betaine, 1,2- hexylene glycols, hydroxyethyl cellulose, polyacrylic acid
Graft starch, EDETATE SODIUM, trehalose, aqueous phase pot is added, after being heated to 80-85 DEG C, is stirred, be pumped into agitated kettle;
Start is uniformly mixed, 30 minutes, 1000rpm/ points, is stopped stirring, is cooled to 40 DEG C;Add PEG-40 hydrogenations
Castor oil, olive oil PEG-7 esters, tocopherol, octyl dodecanol, dried tremella extract, purslane extract, Sodium Hyaluronate,
Dipotassium glycyrrhizinate, beta glucan, silver, continue to stir, be cooled to room temperature, produce elite dew.
Embodiment 4
Elite reveals raw material:Water 67g, hydroxyethyl cellulose 0.3g, polyacrylic acid grafted starch 0.15g, glycerine 3g, 1,3-
Butanediol 6.5g, glycine betaine 0.5g, isoprene 2.0g, 1,2- hexylene glycol 0.5g, EDTA- disodiums 0.05g, PEG-40 hydrogenation castor
Sesame oil 0.30g, olive oil PEG-7 esters 0.30g, tocopherol 0.10g, octyl dodecanol 0.10g, dried tremella extract 0.001g,
Purslane extract 17.5g, trehalose 0.10g, Sodium Hyaluronate 0.005g, dipotassium glycyrrhizinate 0.05g, beta glucan 0.30g,
Silver-colored 0.20g.
The elite dew preparation method be:
Water intaking, glycerine, isoprene, 1,3-BDO, glycine betaine, 1,2- hexylene glycols, hydroxyethyl cellulose, polyacrylic acid
Graft starch, EDETATE SODIUM, trehalose, aqueous phase pot is added, after being heated to 80-85 DEG C, is stirred, be pumped into agitated kettle;
Start is uniformly mixed, 30 minutes, 1000rpm/ points, is stopped stirring, is cooled to 40 DEG C;Add PEG-40 hydrogenations
Castor oil, olive oil PEG-7 esters, tocopherol, octyl dodecanol, dried tremella extract, purslane extract, Sodium Hyaluronate,
Dipotassium glycyrrhizinate, beta glucan, silver, continue to stir, be cooled to room temperature, produce elite dew.
Embodiment 5
Elite reveals raw material:Water 68g, hydroxyethyl cellulose 0.35g, polyacrylic acid grafted starch 0.18g, glycerine 3.5g,
1,3-BDO 7g, glycine betaine 0.55g, isoprene 2.4g, 1,2- hexylene glycol 0.55g, EDTA- disodium 0.05g, PEG-40 hydrogen
Change castor oil 0.32g, olive oil PEG-7 esters 0.32g, tocopherol 0.11g, octyl dodecanol 0.11g, dried tremella extract
0.001g, purslane extract 18g, trehalose 0.11g, Sodium Hyaluronate 0.005g, dipotassium glycyrrhizinate 0.05g, beta glucan
0.30g, silver-colored 0.20g.
The elite dew preparation method be:
Water intaking, glycerine, isoprene, 1,3-BDO, glycine betaine, 1,2- hexylene glycols, hydroxyethyl cellulose, polyacrylic acid
Graft starch, EDETATE SODIUM, trehalose, aqueous phase pot is added, after being heated to 80-85 DEG C, is stirred, be pumped into agitated kettle;
Start is uniformly mixed, 30 minutes, 1000rpm/ points, is stopped stirring, is cooled to 40 DEG C;Add PEG-40 hydrogenations
Castor oil, olive oil PEG-7 esters, tocopherol, octyl dodecanol, dried tremella extract, purslane extract, Sodium Hyaluronate,
Dipotassium glycyrrhizinate, beta glucan, silver, continue to stir, be cooled to room temperature, produce elite dew.
Stability test is studied
Experiment 1:Heat resistant test:Different elite are revealed to the plastic drug package for adding 2 bottles of clean dries, tighten lid, one bottle
It is put into and has been pre-adjusted in the insulating box that temperature is 48 ± 1 DEG C, taken out after 48 hours, mesh is carried out with another bottle after recovery room temperature
Survey is compared.
Experiment 2:Low temperature resistant test:Different elite are revealed to the plastic drug package for adding 2 bottles of clean dries, tighten lid, one bottle
It is put into and has been pre-adjusted in the refrigerator that temperature is -18 ± 1 DEG C, taken out after 48 hours, mesh is carried out with another bottle after recovery room temperature
Survey is compared.
Experiment 3:Light Resistance Test:Different elite are revealed to the plastic drug package for adding 2 bottles of clean dries, tighten lid, one bottle
Place and be exposed to the sun 30 days under sunlight.
Result of the test:It is shown in Table 4.
The stability test result of table 4
Aforementioned stable experiment shows that elite dew of the present invention has good stability.
It is including but not limited to above-mentioned to prepare embodiment.