CN115461086A - miRNA-485抑制剂用于治疗肌萎缩性侧索硬化症(als)的用途 - Google Patents

miRNA-485抑制剂用于治疗肌萎缩性侧索硬化症(als)的用途 Download PDF

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CN115461086A
CN115461086A CN202180026758.0A CN202180026758A CN115461086A CN 115461086 A CN115461086 A CN 115461086A CN 202180026758 A CN202180026758 A CN 202180026758A CN 115461086 A CN115461086 A CN 115461086A
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seq
mir
nucleotides
aspects
protein
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柳金孝
赫韩硕
金大勋
闵贤洙
林云娜
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Biosega Co ltd
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Biosega Co ltd
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
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    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
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    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
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    • A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame
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    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/22—Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
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    • A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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CN202180026758.0A 2020-02-07 2021-02-06 miRNA-485抑制剂用于治疗肌萎缩性侧索硬化症(als)的用途 Pending CN115461086A (zh)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US202062971771P 2020-02-07 2020-02-07
US62/971,771 2020-02-07
US202062989487P 2020-03-13 2020-03-13
US62/989,487 2020-03-13
US202063047147P 2020-07-01 2020-07-01
US63/047,147 2020-07-01
PCT/IB2021/050975 WO2021156832A1 (en) 2020-02-07 2021-02-06 Use of mirna-485 inhibitors for treating amyotrophic lateral sclerosis (als)

Publications (1)

Publication Number Publication Date
CN115461086A true CN115461086A (zh) 2022-12-09

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CN202180026758.0A Pending CN115461086A (zh) 2020-02-07 2021-02-06 miRNA-485抑制剂用于治疗肌萎缩性侧索硬化症(als)的用途

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US (1) US20230131083A1 (https=)
EP (1) EP4100068A4 (https=)
JP (1) JP2023513189A (https=)
KR (1) KR20220154105A (https=)
CN (1) CN115461086A (https=)
AU (1) AU2021215407A1 (https=)
CA (1) CA3166603A1 (https=)
MX (1) MX2022009451A (https=)
WO (1) WO2021156832A1 (https=)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2024245120A1 (en) * 2023-05-26 2024-12-05 Shanghai Vitalgen Biopharma Co., Ltd. Recombinant aav vectors for treating proteinopathies in central nervous system

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Publication number Priority date Publication date Assignee Title
WO2016030899A1 (en) * 2014-08-28 2016-03-03 Yeda Research And Development Co. Ltd. Methods of treating amyotrophic lateral scleroses
WO2017046267A1 (de) * 2015-09-17 2017-03-23 ToposNomos Ltd. Pharmazeutische wirkstoffe zur verwendung in der behandlung von amyotropher lateralsklerose (als) und diagnoseverfahren
WO2018139759A1 (ko) * 2017-01-26 2018-08-02 주식회사 바이오오케스트라 마이크로 rna를 이용한 알츠하이머병 진단방법
WO2018139819A1 (ko) * 2017-01-26 2018-08-02 주식회사 바이오오케스트라 마이크로 rna를 이용한 뇌 질환 예방 또는 치료 용도
US20180334674A1 (en) * 2015-11-19 2018-11-22 Public University Corporation Nagoya City University Antitumor drug delivery formulation
WO2019240223A1 (ja) * 2018-06-13 2019-12-19 公益財団法人川崎市産業振興財団 数平均分子量が３ｋＤａ～１０ｋＤａであるＰＥＧブロックとカチオン性ポリマーとのブロックコポリマーと、アンチセンスオリゴヌクレオチドとを含む、ポリイオンコンプレックスミセル

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US9951330B2 (en) * 2013-07-11 2018-04-24 The Trustees Of Columbia University In The City Of New York Micrornas that silence tau expression
US10844380B1 (en) * 2019-06-17 2020-11-24 Biorchestra Co., Ltd. Uses for prevention or treatment of brain diseases using microrna

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WO2016030899A1 (en) * 2014-08-28 2016-03-03 Yeda Research And Development Co. Ltd. Methods of treating amyotrophic lateral scleroses
WO2017046267A1 (de) * 2015-09-17 2017-03-23 ToposNomos Ltd. Pharmazeutische wirkstoffe zur verwendung in der behandlung von amyotropher lateralsklerose (als) und diagnoseverfahren
US20180334674A1 (en) * 2015-11-19 2018-11-22 Public University Corporation Nagoya City University Antitumor drug delivery formulation
WO2018139759A1 (ko) * 2017-01-26 2018-08-02 주식회사 바이오오케스트라 마이크로 rna를 이용한 알츠하이머병 진단방법
WO2018139819A1 (ko) * 2017-01-26 2018-08-02 주식회사 바이오오케스트라 마이크로 rna를 이용한 뇌 질환 예방 또는 치료 용도
WO2019240223A1 (ja) * 2018-06-13 2019-12-19 公益財団法人川崎市産業振興財団 数平均分子量が３ｋＤａ～１０ｋＤａであるＰＥＧブロックとカチオン性ポリマーとのブロックコポリマーと、アンチセンスオリゴヌクレオチドとを含む、ポリイオンコンプレックスミセル

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ATSUSHI HARADA等: "Physicochemical properties and nuclease resistance of antisenseoligodeoxynucleotides entrapped in the core of polyion complex micelles composed of poly(ethylene glycol)–poly(L-Lysine) block copolymers", EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES, no. 13, 31 December 2001 (2001-12-31), pages 35 - 42 *
HUAN-CHIEH等: "Reevaluating the Substrate Specificity of the L-Type Amino Acid Transporter (LAT1)", J. MED. CHEM., no. 61, 26 July 2018 (2018-07-26), pages 7358 *
KUN SHAO等: "Functionalized Nanoscale Micelles with Brain Targeting Ability and Intercellular Microenvironment Biosensitivity for Anti-Intracranial Infection Applications", ADVANCED HEALTHCARE MATERIALS, vol. 4, no. 2, 13 August 2014 (2014-08-13), pages 291 - 300 *
MANGELSDORF等: "Healing of Amyotrophic Lateral Sclerosis A Case Report", COMPLEMENT MED RES, no. 24, 12 June 2017 (2017-06-12), pages 175 *
张浩等: "miRNA-485-3p和miRNA-485-5p在阿尔茨海默病发病中的作用", 中国医学创新, vol. 19, no. 32, 29 November 2022 (2022-11-29), pages 179 - 183 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2024245120A1 (en) * 2023-05-26 2024-12-05 Shanghai Vitalgen Biopharma Co., Ltd. Recombinant aav vectors for treating proteinopathies in central nervous system

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US20230131083A1 (en) 2023-04-27
AU2021215407A1 (en) 2022-08-25
EP4100068A4 (en) 2024-03-20
EP4100068A1 (en) 2022-12-14
MX2022009451A (es) 2022-10-31
CA3166603A1 (en) 2021-08-12
KR20220154105A (ko) 2022-11-21
JP2023513189A (ja) 2023-03-30

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