CN115430031A - 一种多功能美容微针贴片及其批量化制备方法 - Google Patents
一种多功能美容微针贴片及其批量化制备方法 Download PDFInfo
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- CN115430031A CN115430031A CN202210792533.2A CN202210792533A CN115430031A CN 115430031 A CN115430031 A CN 115430031A CN 202210792533 A CN202210792533 A CN 202210792533A CN 115430031 A CN115430031 A CN 115430031A
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- Prior art keywords
- microneedle
- template
- microneedle patch
- solution
- multifunctional cosmetic
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Abstract
本发明涉及一种多功能美容微针贴片批量化制备方法，包括如下步骤：将微针针尖溶液灌注在模板上，置于真空条件，刮去多余溶液后干燥；将配对掩模板放置在模板上，将微针上层溶液灌注在模板上，置于真空条件，用刮板刮去多余溶液，干燥后得到微针主体结构；去除掩模板，用粘有粘性抗菌基底的底板取下干燥后的微针贴片。本发明考虑到了微针之后的消炎抗菌作用，不再需要不透气的医用胶带等来将微针固定在皮肤上，赋予基底粘附性，可以粘在皮肤上，其柔韧好，与皮肤贴合度好，透气性好，让用户获得了更好的使用体验。本发明提供的微针贴片可以批量化生产。
Description
技术领域
本发明属于化妆品美容技术领域，具体涉及一种多功能美容微针贴片及其批量化制备方法。
背景技术
近几十年来，微针在美容美体领域取得了重大进展，在市场上已使用十多年，主要用于美白、除皱、去痘印等领域。随着可溶性微针的应用越来越被人们接受和认可，美容微针贴片也日渐普及。
微针是指直径小于几十微米、长度为25-2000μm的针状结构。可溶性美容微针贴片是由数枚至数百枚细小微针组成的阵列，药物或者生物活性物质直接封装在针尖以及基底上，当微针刺入皮肤后，微针完全溶解于皮肤，微针中有效成分释放到皮下，进入表皮层甚至是真皮层，从而增强人体皮肤对有效成分的吸收。与目前流行的水光针，黄金微针不同，可溶性美容微针贴片不易刺激神经末梢，不会或较少产生疼痛感，操作简单，可以轻松在任何场合使用，可以提高患者依从性，减轻医护人员负担，提高微针美容的安全性和有效性。
越来越多的美容微针贴片出现在市面上，都是用透明质酸作为基质材料来制备可溶性微针，有些会添加其他的活性成分提高微针的美容效果，常用的小分子成分例如抗坏血酸，视黄基视黄酸酯，烟酰胺，绿茶提取物和正丁基间苯二酚等，制成具有除皱美白保湿等多种功效的可溶性透明质酸美容微针产品。但这些微针贴片大多是贴在医用胶带上，很少考虑透气性，而且使用过程中经常伴随着红肿过敏感染等风险，都没有考虑到微针贴片使用后的后续处理以及贴片的透气性。
发明内容
本发明为了解决上述技术问题，进而提出一种多功能美容微针贴片及其批量化制备方法。
本发明涉及一种多功能美容微针贴片批量化制备方法，包括如下步骤：
将微针针尖溶液灌注在模板上，置于真空条件，刮去多余溶液后干燥；
将配对掩模板放置在模板上，将微针上层溶液灌注在模板上，置于真空条件，用刮板刮去多余溶液，干燥后得到微针主体结构；
去除掩模板，用粘有粘性柔性基底的底板取下干燥后的微针贴片。
所述模板上有多个排列整齐的微针阵列，每个微针阵列由1-500个圆锥形孔构成，每根微针高度为100-1000μm，针尖直径为1-10μm。
掩模板与模板配对设置，微针阵列处空心，其余位置为实心。
所述微针针尖溶液中，基质材料与美容成分的质量配比为(1％-20％)：(1％-10％)；微针上层溶液中，基质材料与消炎成分的配比为(1％-20％)：(1％-10％)。
所述基质材料为透明质酸钠、羧甲基纤维素钠、聚乙烯醇、聚乙烯基吡咯烷酮、硫酸软骨素、羟丙甲纤维素、碳水化合物材料、藻酸盐、聚硅酮、贻贝粘蛋白中的一种或几种。
述美容成分为维生素C、烟酰胺、视黄醇中的一种或者几种；所述消炎成分为乳酸、透明质酸钠、尿囊素、烟酰胺、积雪草、小球藻、寡肽中的一种或者几种。
在真空条件下放置时间为10-120min，针尖干燥时间为1-12h，微针上部干燥时间为1-12h，干燥温度为室温-60℃。
所述柔性基底为柠檬酸、环糊精、戊二醛、聚乙烯醇、壳聚糖以及甘油中的一种或者几种。
柔性基底包含抗菌成分，与微针主体组装，形成最终微针贴片，柔性基底中的抗菌物质为抗生素、银纳米粒子、抗菌聚合物、阳离子碳点、壳聚糖等一种或几种。
本发明还涉及一种根据所述的方法制备的多功能美容微针贴片。
有益效果
本发明考虑到了微针之后的消炎抗菌作用，不再需要不透气的医用胶带等来将微针固定在皮肤上，赋予基底粘附性，可以粘在皮肤上，其柔韧好，与皮肤贴合度好，透气性好，让用户获得了更好的使用体验。本发明提供的微针贴片可以批量化生产。
附图说明
图1为本发明中微针贴片批量化制备方法流程图；
图2为本发明中微针结构图；
图3为本发明中微针示意图；
图4为本发明中微针针尖示意图；
图5为本发明中微针压缩试验载荷-位移示意图。
具体实施方式
以下结合图1至5对本实施方式进行具体说明。
本发明涉及一种多功能美容微针贴片批量化制备方法，包括如下步骤：
将微针针尖溶液灌注在模板上，置于真空条件，刮去多余溶液后干燥；
将配对掩模板放置在模板上，将微针上层溶液灌注在模板上，置于真空条件，用刮板刮去多余溶液，干燥后得到微针主体结构；
去除掩模板，用粘有粘性抗菌基底的底板取下干燥后的微针贴片。
优选地，上述步骤中，在真空条件下放置时间为10-120min，针尖干燥时间为1-12h，微针上部干燥时间为1-12h，干燥温度为室温-60℃。
优选地，模板上有多个排列整齐的微针阵列，每个微针阵列由1-500个圆锥形孔构成，每根微针高度为100-1000μm，针尖直径为1-10μm。掩模板与模板配对设置，微针阵列处空心，其余位置为实心。
微针针尖溶液中，基质材料与美容成分的质量配比为(1％-20％)：(1％-10％)；微针上层溶液中，基质材料与消炎成分的配比为(1％-20％)：(1％-10％)。基质材料为透明质酸钠、羧甲基纤维素钠、聚乙烯醇、聚乙烯基吡咯烷酮、硫酸软骨素、羟丙甲纤维素、碳水化合物材料、藻酸盐、聚硅酮、贻贝粘蛋白中的一种或几种。美容成分为维生素C、烟酰胺、视黄醇中的一种或者几种；所述消炎成分为乳酸、透明质酸钠、尿囊素、烟酰胺、积雪草、小球藻、寡肽中的一种或者几种。
柔性基底制备材料为柠檬酸、环糊精、戊二醛、聚乙烯醇、壳聚糖以及甘油中的一种或者几种。柔性基底中的抗菌物质为抗生素、银纳米粒子、抗菌聚合物、阳离子碳点、壳聚糖等一种或几种。
本发明还涉及一种根据所述的方法制备的多功能美容微针贴片。
实施例1
本实施例涉及多功能美容微针贴片的批量化制备方法，并检测该贴片的机械性能，具体操作包括：
使用柔韧性较好的PDMS作为微针模板的材料，将预聚物与固化剂根据10:1(m/ m)的比例在常温混合加入到烧杯中，并且用玻璃棒上下转使得混合物搅拌均匀之后，在真空条件下去除气泡，然后将其倒入到金属模具中，置于真空条件下20min，然后放入到烘箱中在60℃固化1h，从金属微针上轻轻剥离便获得PDMS微针模板。
将0.1g维生素C溶于5g水中，向其中加入0.2g透明质酸钠(200KDa-400 KDa)，过夜溶胀。将该溶液灌注在聚二甲基硅氧烷(PDMS)模板上，置于真空条件下20min，用刮板刮去多余溶液，50℃干燥4h。将制备好的配对掩模板放置在模板上，将0.1g透明质酸钠(200KDa-400KDa)溶于5g水中，过夜溶胀。将0.4g水杨酸溶于2mL酒精中。向溶胀好的透明质酸钠溶液中加入300μL水杨酸溶液，搅拌均匀直至形成乳白色溶液。将水杨酸透明质酸混合物涂抹在PDMS模板上，并将模板放置在真空条件下20min，用刮板刮去多余溶液，50℃干燥4h后即可得到微针主体结构。去除掩模板。
柔性黏性基底制作：称取2.0g壳聚糖粉末溶于2％的乙酸溶液中，在磁力搅拌台上以500r/min搅拌2h，至凝胶为淡黄色透明，过夜静置备用，或者使用前用真空抽滤去泡。取一定量的凝胶溶液于另一烧杯中，加入15％体积的甘油，以及轻微混匀，静置后在模具上浇注适量的混合凝胶溶液，注意不要产生气泡。将盛有凝胶液体的模具放在阳光下自然风干，大约1天后，薄膜成型，放入无尘柜中，后期可裁剪使用。
将黏性基底粘在底板上，将另一面粘在有干燥微针的PDMS模板上，取下干燥微针贴片，进行剪切封装。
压缩试验
将微针贴片放置在平坦的不锈钢压板上，贴片尖端朝上，同时以0.5mm/min的应变速率对微针贴片尖端施加垂直力，直到达到0.3N/针的预定义力。通过体外皮肤刺穿实验来显示微针的刺入能力。用来测定体外刺入能力的材料是离体的小鼠的皮肤。具体地，将老鼠脱颈处死，剥离背部皮肤，小心去除皮下脂肪组织及粘连物，用生理盐水反复冲洗干净，用电动剃须刀和脱毛膏去除鼠毛，擦干表面水分。将不同微针贴片在10N的力下垂直扎入鼠皮并保持3min后移去微针阵列，用罗丹明染色，利用显微镜和手机相机观察微针扎入情况。随后对老鼠皮肤组织的穿透深度进行组织学评估。将微针贴片垂直扎入鼠皮并保持3min后移去微针阵列，将皮肤泡入4％多聚甲醛固定液，24h后进行包埋切片处理。然后对切片进行苏木素-伊红(HE染色)，PBS漂洗，磷酸-甘油封片，在光学显微镜下观察，并用显微成像系统拍照记录。
上述微针贴片的批量化制备流程示意图如图1所示，结构图和实物图如图2和图 3所示，微针针尖结构如图4所示，微针贴片针尖结构完整。微针压缩实验机械强度示意图如图5所示。微针贴片能够承受高达每针0.3N的载荷力而不断裂。根据文献得知，0.3N/针具有足够的机械强度刺穿皮肤角质层。将微针扎入鼠皮，移除微针后，与穿刺部位相对应的位置出现一系列红色斑点，表明微针能够成功刺穿皮肤。将皮肤表面有效穿刺点的个数与贴片上的总针数基本相同，表明微针具有尖锐的尖端和良好的机械强度。与此同时，皮肤组织学分析表明穿刺处的皮肤被微针成功穿透。
实施例2
本实施例涉及多功能美容微针贴片的批量化制备方法，并检测该贴片的机械性能，具体操作包括：
将0.1g维生素C溶于5g水中，向其中加入0.1g透明质酸钠(200KDa-400 KDa)，过夜溶胀。将该溶液灌注在聚二甲基硅氧烷(PDMS)模板上，置于真空条件下40min，用刮板刮去多余溶液，室温下干燥12h。将制备好的配对掩模板放置在模板上，将0.2g透明质酸钠(200KDa-400KDa)溶于5g水中，过夜溶胀。将0.2g水杨酸溶于2mL酒精中。向溶胀好的透明质酸钠溶液中加入300μL水杨酸溶液，搅拌均匀直至形成乳白色溶液。将水杨酸透明质酸混合物涂抹在PDMS模板上，并将模板放置在真空条件下40min，用刮板刮去多余溶液，室温下干燥12h后即可得到微针主体结构。去除掩模板。
柔性黏性基底制作：称取2.0g壳聚糖粉末溶于2％的乙酸溶液中，在磁力搅拌台上以500r/min搅拌2h，至凝胶为淡黄色透明，过夜静置备用，或者使用前用真空抽滤去泡。取一定量的凝胶溶液于另一烧杯中，加入15％体积的甘油，轻微混匀，静置后在模具上浇注适量的混合凝胶溶液。将盛有凝胶液体的模具放在阳光下自然风干，大约1天后，薄膜成型，放入无尘柜中，后期可裁剪使用。
将黏性基底粘在底板上，将另一面粘在有干燥微针的PDMS模板上，取下干燥微针贴片，进行剪切封装。
压缩试验
将微针贴片放置在平坦的不锈钢压板上，贴片尖端朝上，同时以0.5mm/min的应变速率对微针贴片尖端施加垂直力，直到达到0.3N/针的预定义力。通过体外皮肤刺穿实验来显示微针的刺入能力。用来测定体外刺入能力的材料是离体的小鼠的皮肤。具体地，将老鼠脱颈处死，剥离背部皮肤，小心去除皮下脂肪组织及粘连物，用生理盐水反复冲洗干净，用电动剃须刀和脱毛膏去除鼠毛，擦干表面水分。将不同微针贴片在10N的力下垂直扎入鼠皮并保持3min后移去微针阵列，用罗丹明染色，利用显微镜和手机相机观察微针扎入情况。随后对老鼠皮肤组织的穿透深度进行组织学评估。将微针贴片垂直扎入鼠皮并保持3min后移去微针阵列，将皮肤泡入4％多聚甲醛固定液，24h后进行包埋切片处理。然后对切片进行苏木素-伊红(HE染色)，PBS漂洗，磷酸-甘油封片，在光学显微镜下观察，并用显微成像系统拍照记录。
上述内容仅为本发明较好的实施案例，并非用于限制本发明的实施方案，本领域普通技术人员根据本发明的主要构思和精神，可以十分方便地进行相应的变通或修改，如室内标准试件的数量、施工现场取芯的数量，可根据精度要求进行增减，故本发明的保护范围应以权利要求书所要求的保护范围为准。
Claims (10)
1.一种多功能美容微针贴片批量化制备方法，其特征在于，包括如下步骤：
将微针针尖溶液灌注在模板上，置于真空条件，刮去多余溶液后干燥；
将配对掩模板放置在模板上，将微针上层溶液灌注在模板上，置于真空条件，用刮板刮去多余溶液，干燥后得到微针主体结构；
去除掩模板，用粘有粘性柔性基底的底板取下干燥后的微针贴片。
2.根据权利要求1所述的一种多功能美容微针贴片批量化制备方法，其特征在于，所述模板上有多个排列整齐的微针阵列，每个微针阵列由1-500个圆锥形孔构成，每根微针高度为100-1000μm，针尖直径为1-10μm。
3.根据权利要求2所述的一种多功能美容微针贴片批量化制备方法，其特征在于，掩模板与模板配对设置，微针阵列处空心，其余位置为实心。
4.根据权利要求1所述的一种多功能美容微针贴片批量化制备方法，其特征在于，所述微针针尖溶液中，基质材料与美容成分的质量配比为(1％-20％)：(1％-10％)；微针上层溶液中，基质材料与消炎成分的配比为(1％-20％)：(1％-10％)。
5.根据权利要求4所述的一种多功能美容微针贴片批量化制备方法，其特征在于，所述基质材料为透明质酸钠、羧甲基纤维素钠、聚乙烯醇、聚乙烯基吡咯烷酮、硫酸软骨素、羟丙甲纤维素、碳水化合物材料、藻酸盐、聚硅酮、贻贝粘蛋白中的一种或几种。
6.根据权利要求4所述的一种多功能美容微针贴片批量化制备方法，其特征在于，述美容成分为维生素C、烟酰胺、视黄醇中的一种或者几种；所述消炎成分为乳酸、透明质酸钠、尿囊素、烟酰胺、积雪草、小球藻、寡肽中的一种或者几种。
7.根据权利要求1所述的一种多功能美容微针贴片批量化制备方法，其特征在于，在真空条件下放置时间为10-120min，针尖干燥时间为1-12h，微针上部干燥时间为1-12h，干燥温度为室温-60℃。
8.根据权利要求1所述的一种多功能美容微针贴片批量化制备方法，其特征在于，所述柔性基底为柠檬酸、环糊精、戊二醛、聚乙烯醇、壳聚糖以及甘油中的一种或者几种。
9.根据权利要求4所述的一种多功能美容微针贴片批量化制备方法，其特征在于，柔性基底包含抗菌成分，与微针主体组装，形成最终微针贴片，柔性基底中的抗菌物质为抗生素、银纳米粒子、抗菌聚合物、阳离子碳点、壳聚糖等一种或几种。
10.一种根据权利要求1至9任一项所述的方法制备的多功能美容微针贴片。
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